SLC22A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyol transport (GO:0015791)9.86667647
2drug transport (GO:0015893)9.18633747
3organic cation transport (GO:0015695)8.72000596
4phosphate ion transport (GO:0006817)8.35352499
5exogenous drug catabolic process (GO:0042738)7.85594358
6lysine catabolic process (GO:0006554)7.78531168
7lysine metabolic process (GO:0006553)7.78531168
8actin filament depolymerization (GO:0030042)7.64165053
9collecting duct development (GO:0072044)7.56870900
10drug catabolic process (GO:0042737)7.48148089
11glyoxylate metabolic process (GO:0046487)7.31316183
12vitamin A metabolic process (GO:0006776)7.20094230
13quaternary ammonium group transport (GO:0015697)7.19037904
14phosphate ion transmembrane transport (GO:0035435)6.77749107
15cysteine metabolic process (GO:0006534)6.64783360
16tricarboxylic acid metabolic process (GO:0072350)6.24047108
17nephron epithelium development (GO:0072009)6.17486537
18cell volume homeostasis (GO:0006884)6.17345269
19response to mercury ion (GO:0046689)6.17171473
20gamma-aminobutyric acid transport (GO:0015812)6.12627146
21nonribosomal peptide biosynthetic process (GO:0019184)5.99055152
22cardiovascular system development (GO:0072358)5.86959174
23vitamin D metabolic process (GO:0042359)5.71643292
24regulation of protein polyubiquitination (GO:1902914)5.60709246
25positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc5.50270471
26response to water (GO:0009415)5.49468393
27short-chain fatty acid metabolic process (GO:0046459)5.48270988
28excretion (GO:0007588)5.46697364
29glutathione biosynthetic process (GO:0006750)5.38979046
30trivalent inorganic anion homeostasis (GO:0072506)5.35069707
31phosphate ion homeostasis (GO:0055062)5.35069707
32aspartate family amino acid catabolic process (GO:0009068)5.32545173
33toxin transport (GO:1901998)5.32112632
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.29170975
35branched-chain amino acid metabolic process (GO:0009081)5.22698906
36renal absorption (GO:0070293)5.18004552
37amino-acid betaine transport (GO:0015838)5.06520210
38carnitine transport (GO:0015879)5.06520210
39positive regulation of catenin import into nucleus (GO:0035413)5.03640450
40cellular response to electrical stimulus (GO:0071257)5.01519601
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.94543736
42L-phenylalanine metabolic process (GO:0006558)4.94543736
43negative regulation of cholesterol transport (GO:0032375)4.94242535
44negative regulation of sterol transport (GO:0032372)4.94242535
45proline metabolic process (GO:0006560)4.93987180
46hyperosmotic response (GO:0006972)4.93213269
47cellular modified amino acid catabolic process (GO:0042219)4.91148598
48nephron tubule formation (GO:0072079)4.91144955
49serine family amino acid catabolic process (GO:0009071)4.88971347
50glycoside metabolic process (GO:0016137)4.88372441
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.87490515
52L-phenylalanine catabolic process (GO:0006559)4.87490515
53positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)4.83784705
54serine family amino acid metabolic process (GO:0009069)4.75974786
55metanephric tubule development (GO:0072170)4.75215075
56metanephric nephron tubule development (GO:0072234)4.75215075
57valine metabolic process (GO:0006573)4.58071366
58activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.56066617
59aromatic amino acid family catabolic process (GO:0009074)4.56012124
60homocysteine metabolic process (GO:0050667)4.55497630
61modified amino acid transport (GO:0072337)4.53361615
62amino-acid betaine metabolic process (GO:0006577)4.39537244
63metanephric nephron epithelium development (GO:0072243)4.37782217
64peptide biosynthetic process (GO:0043043)4.32242694
65tryptophan catabolic process (GO:0006569)4.30674094
66indole-containing compound catabolic process (GO:0042436)4.30674094
67indolalkylamine catabolic process (GO:0046218)4.30674094
68fatty acid beta-oxidation (GO:0006635)4.28164176
69inositol metabolic process (GO:0006020)4.22955324
70fructose metabolic process (GO:0006000)4.20729288
71oligosaccharide catabolic process (GO:0009313)4.20454279
72peptide catabolic process (GO:0043171)4.14931875
73regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.13891453
74tryptophan metabolic process (GO:0006568)4.13677753
75branched-chain amino acid catabolic process (GO:0009083)4.12333177
762-oxoglutarate metabolic process (GO:0006103)4.09741925
77response to parathyroid hormone (GO:0071107)4.04241570
78serine family amino acid biosynthetic process (GO:0009070)4.03881785
79response to thyroid hormone (GO:0097066)4.00467333
80metanephric epithelium development (GO:0072207)3.99359975
81fatty acid oxidation (GO:0019395)3.96180901
82nephron tubule development (GO:0072080)3.93482437
83carnitine metabolic process (GO:0009437)3.91876151
84mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.90458523
85lipid oxidation (GO:0034440)3.88849124
86cellular ketone body metabolic process (GO:0046950)3.88640101
87NADH metabolic process (GO:0006734)3.86921463
88beta-amyloid metabolic process (GO:0050435)3.78748264
89negative regulation of metanephros development (GO:0072217)3.78571471
90cellular amino acid catabolic process (GO:0009063)3.78179953
91acetyl-CoA metabolic process (GO:0006084)3.77557457
92cellular response to ammonium ion (GO:0071242)3.77314560
93glutathione metabolic process (GO:0006749)3.76433598
94cellular hyperosmotic response (GO:0071474)3.75632371
95glomerular visceral epithelial cell development (GO:0072015)3.72672640
96response to growth hormone (GO:0060416)3.72039990
97glutamate metabolic process (GO:0006536)3.68559260
98flavonoid metabolic process (GO:0009812)3.68013068
99vitamin transport (GO:0051180)3.66142247
100drug metabolic process (GO:0017144)3.61977294
101alpha-amino acid catabolic process (GO:1901606)3.61741637
102glucuronate metabolic process (GO:0019585)3.61597525
103uronic acid metabolic process (GO:0006063)3.61597525
104detection of light stimulus involved in visual perception (GO:0050908)3.56751648
105detection of light stimulus involved in sensory perception (GO:0050962)3.56751648
106fatty acid catabolic process (GO:0009062)3.54740709
107regulation of protein localization to cell surface (GO:2000008)3.54391241
108response to phenylpropanoid (GO:0080184)3.53419993
109indole-containing compound metabolic process (GO:0042430)3.53336924
110sulfur amino acid catabolic process (GO:0000098)3.51890033
111nephron tubule morphogenesis (GO:0072078)3.49473344
112nephron epithelium morphogenesis (GO:0072088)3.49473344
113renal tubule development (GO:0061326)3.48226580
114response to vitamin A (GO:0033189)3.46988803
115N-acetylneuraminate metabolic process (GO:0006054)3.46118236
116response to copper ion (GO:0046688)3.43762981
117response to magnesium ion (GO:0032026)3.43721607
118organic acid catabolic process (GO:0016054)3.41994680
119carboxylic acid catabolic process (GO:0046395)3.41994680
120glutathione derivative metabolic process (GO:1901685)3.39006483
121glutathione derivative biosynthetic process (GO:1901687)3.39006483
122aromatic amino acid family metabolic process (GO:0009072)3.38836627
123cellular response to vitamin D (GO:0071305)3.38437363
124response to lead ion (GO:0010288)3.37225120
125monocarboxylic acid catabolic process (GO:0072329)3.36144195
126neurotransmitter biosynthetic process (GO:0042136)3.34320045
127ketone body metabolic process (GO:1902224)3.33766505
128cellular glucuronidation (GO:0052695)3.33072667
129positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.32824604
130glutamine family amino acid catabolic process (GO:0009065)3.32271441
131regulation of apoptotic process involved in morphogenesis (GO:1902337)3.32123615
132bone remodeling (GO:0046849)3.29719877
133sulfur compound transport (GO:0072348)3.29291596
134pattern specification involved in kidney development (GO:0061004)3.27327526
135glomerular epithelial cell development (GO:0072310)3.26918620
136regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.23970773
137negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.22018525
138S-adenosylmethionine metabolic process (GO:0046500)3.16606363
139urogenital system development (GO:0001655)3.14763419
140positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.13246393
141* renal system process (GO:0003014)3.12267674
142protein-chromophore linkage (GO:0018298)3.07933002
143embryonic retina morphogenesis in camera-type eye (GO:0060059)3.07273763
144positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.05091195
145potassium ion import (GO:0010107)3.02468076
146positive regulation of ERBB signaling pathway (GO:1901186)2.98466101
147sodium ion export (GO:0071436)2.97732131
148behavioral response to nicotine (GO:0035095)2.97690526
149response to salt stress (GO:0009651)2.96786293
150ERK1 and ERK2 cascade (GO:0070371)2.94196111
151inorganic anion transport (GO:0015698)2.90721835
152chloride transmembrane transport (GO:1902476)2.90179617
153cellular sodium ion homeostasis (GO:0006883)2.87309457
154regulation of fever generation (GO:0031620)2.86142003
155microglial cell activation (GO:0001774)2.84460842
156protoporphyrinogen IX biosynthetic process (GO:0006782)2.84176120
157regulation of anion transport (GO:0044070)2.83877773
158positive regulation of heat generation (GO:0031652)2.83858291
159cellular potassium ion homeostasis (GO:0030007)2.83102060
160regulation of cholesterol efflux (GO:0010874)2.82295743
161sodium ion transport (GO:0006814)2.81055352
162mammary gland alveolus development (GO:0060749)2.80607943
163regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:22.80503477
164metanephric mesenchyme development (GO:0072075)2.76981025
165regulation of potassium ion transmembrane transporter activity (GO:1901016)2.76462814
166fat-soluble vitamin metabolic process (GO:0006775)2.75424246
167inorganic anion transmembrane transport (GO:0098661)2.73487007
168chloride transport (GO:0006821)2.73295699
169sodium ion homeostasis (GO:0055078)2.72706306
170kidney epithelium development (GO:0072073)2.69900044
171L-methionine salvage (GO:0071267)2.69787374
172L-methionine biosynthetic process (GO:0071265)2.69787374
173amino acid salvage (GO:0043102)2.69787374
174aminoglycoside antibiotic metabolic process (GO:0030647)11.2421272
175drug transmembrane transport (GO:0006855)11.0233752
176urate metabolic process (GO:0046415)10.9983908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.89971404
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.26676460
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.44223866
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.06803771
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.70738731
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.65247669
7EZH2_22144423_ChIP-Seq_EOC_Human3.01957549
8HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.79627715
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.74472020
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66569194
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.59325815
12CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.48267342
13GBX2_23144817_ChIP-Seq_PC3_Human2.41116721
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.39686808
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37975515
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.35587406
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.34341408
18CDX2_20551321_ChIP-Seq_CACO-2_Human2.26741592
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.20473532
20AR_21909140_ChIP-Seq_LNCAP_Human2.16842852
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15596305
22DROSHA_22980978_ChIP-Seq_HELA_Human2.12940943
23CLOCK_20551151_ChIP-Seq_293T_Human2.04603328
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03706306
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97990513
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97361368
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88214900
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87558258
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.87390009
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.86026075
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.85491271
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.83957943
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83377508
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81583785
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79003303
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78520442
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78520442
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.78257666
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78130148
40IGF1R_20145208_ChIP-Seq_DFB_Human1.77889373
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70124057
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.69702631
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67946492
44HNF4A_19822575_ChIP-Seq_HepG2_Human1.67565031
45LXR_22292898_ChIP-Seq_THP-1_Human1.64585545
46TAF15_26573619_Chip-Seq_HEK293_Human1.64517272
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60870147
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.56359228
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.53165428
50SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47974179
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46776935
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.45610376
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42834426
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42106833
55RACK7_27058665_Chip-Seq_MCF-7_Human1.40647282
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40628522
57GATA4_25053715_ChIP-Seq_YYC3_Human1.38600813
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36223996
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35883061
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34899044
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33424764
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.31248740
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.30763913
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30706553
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30379160
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.30118413
67VDR_24787735_ChIP-Seq_THP-1_Human1.29902934
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.28361600
69* SMAD4_21799915_ChIP-Seq_A2780_Human1.27642210
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26781880
71KLF4_18555785_Chip-Seq_ESCs_Mouse1.26435271
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25282142
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24688139
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.24656400
75EGR1_19032775_ChIP-ChIP_M12_Human1.22448773
76SMAD3_21741376_ChIP-Seq_HESCs_Human1.22396741
77VDR_22108803_ChIP-Seq_LS180_Human1.22110648
78ER_23166858_ChIP-Seq_MCF-7_Human1.21579071
79P53_22387025_ChIP-Seq_ESCs_Mouse1.20969001
80BCAT_22108803_ChIP-Seq_LS180_Human1.20304415
81RXR_22108803_ChIP-Seq_LS180_Human1.18874020
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.18716204
83TBX20_22328084_ChIP-Seq_HEART_Mouse1.18560036
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.18560036
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15313186
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13575660
87NANOG_19829295_ChIP-Seq_ESCs_Human1.13561201
88SOX2_19829295_ChIP-Seq_ESCs_Human1.13561201
89GATA6_25053715_ChIP-Seq_YYC3_Human1.12286848
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11941347
91OCT4_18555785_Chip-Seq_ESCs_Mouse1.11752914
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11511941
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10299065
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.09845881
95REST_21632747_ChIP-Seq_MESCs_Mouse1.09259884
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.06793319
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06791080
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04796316
99RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04499395
100KDM2B_26808549_Chip-Seq_REH_Human1.03851620
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03036595
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03000470
103SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02597132
104ERG_21242973_ChIP-ChIP_JURKAT_Human1.01981943
105P300_18555785_Chip-Seq_ESCs_Mouse1.01976814
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01465701
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01445033
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01249458
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00731700
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00523938
111TCF4_22108803_ChIP-Seq_LS180_Human1.00195882
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99255794
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99104735
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.98997168
115TCF4_23295773_ChIP-Seq_U87_Human0.98627868
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97106169
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96188580
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95207014
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94884142
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93851675
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93746834
122P300_19829295_ChIP-Seq_ESCs_Human0.93482875
123SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93086332
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92988848
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92923666
126AHR_22903824_ChIP-Seq_MCF-7_Human0.92383468
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91892253
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91626688
129SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91529052
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91511112
131ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91416957
132CMYC_18555785_Chip-Seq_ESCs_Mouse0.90977793
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.90586250
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.90505502
135SMAD3_21741376_ChIP-Seq_EPCs_Human0.89981459
136GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89610465
137ZFX_18555785_Chip-Seq_ESCs_Mouse0.89339897
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.89310007
139WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88987998
140* CBP_21632823_ChIP-Seq_H3396_Human0.88834332
141STAT3_23295773_ChIP-Seq_U87_Human0.88811938
142CJUN_26792858_Chip-Seq_BT549_Human0.88769764
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88702766
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88684930
145SOX2_20726797_ChIP-Seq_SW620_Human0.87244501
146MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86825426
147PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85458931
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85269120
149GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83883984
150MYC_19915707_ChIP-ChIP_AK7_Human0.83534162
151RAC3_21632823_ChIP-Seq_H3396_Human0.83270851
152SMC4_20622854_ChIP-Seq_HELA_Human0.82287691
153CDX2_22108803_ChIP-Seq_LS180_Human0.81741845
154GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81248229
155RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80853108
156GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78831703
157SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77730917
158TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74913544
159NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74671509
160TP63_23658742_ChIP-Seq_EP156T_Human0.74340028
161ARNT_22903824_ChIP-Seq_MCF-7_Human0.74249446
162BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73570050
163P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.73142372
164P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72844580
165TAF2_19829295_ChIP-Seq_ESCs_Human0.72498156
166WT1_25993318_ChIP-Seq_PODOCYTE_Human0.72207052
167P68_20966046_ChIP-Seq_HELA_Human0.71803969
168KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.70628718
169TP63_22573176_ChIP-Seq_HFKS_Human0.70264850
170CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.69910436
171CREB1_26743006_Chip-Seq_LNCaP_Human0.69875765
172TET1_21451524_ChIP-Seq_MESCs_Mouse0.69627118
173SOX2_18692474_ChIP-Seq_MEFs_Mouse0.69586088
174GATA2_19941826_ChIP-Seq_K562_Human0.69296888
175TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68615729
176SMAD4_21741376_ChIP-Seq_EPCs_Human0.68331603
177FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.66082263
178EOMES_21245162_ChIP-Seq_HESCs_Human0.66045980
179MITF_21258399_ChIP-Seq_MELANOMA_Human0.65851815
180CEBPB_22108803_ChIP-Seq_LS180_Human0.64693424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.68215697
2MP0004043_abnormal_pH_regulation6.22645575
3MP0003011_delayed_dark_adaptation6.13335467
4MP0002139_abnormal_hepatobiliary_system5.20820771
5MP0004019_abnormal_vitamin_homeostasis5.09498598
6MP0005332_abnormal_amino_acid4.97464319
7MP0002138_abnormal_hepatobiliary_system4.21096787
8MP0001765_abnormal_ion_homeostasis3.84060603
9* MP0009643_abnormal_urine_homeostasis3.75296446
10MP0003195_calcinosis3.66658522
11MP0005636_abnormal_mineral_homeostasis3.16625116
12MP0008875_abnormal_xenobiotic_pharmacok3.03600743
13MP0005377_hearing/vestibular/ear_phenot2.95321128
14MP0003878_abnormal_ear_physiology2.95321128
15MP0001756_abnormal_urination2.85410459
16MP0001958_emphysema2.84142237
17* MP0002136_abnormal_kidney_physiology2.76225294
18MP0003252_abnormal_bile_duct2.47709695
19MP0005058_abnormal_lysosome_morphology2.39486391
20MP0005365_abnormal_bile_salt2.32547930
21MP0005085_abnormal_gallbladder_physiolo2.26747659
22MP0003183_abnormal_peptide_metabolism1.84901371
23MP0003186_abnormal_redox_activity1.79543446
24MP0004885_abnormal_endolymph1.75250654
25MP0005584_abnormal_enzyme/coenzyme_acti1.71864760
26MP0005083_abnormal_biliary_tract1.71815351
27MP0000538_abnormal_urinary_bladder1.58447251
28MP0001270_distended_abdomen1.58316230
29MP0005084_abnormal_gallbladder_morpholo1.58283571
30MP0000534_abnormal_ureter_morphology1.53509229
31MP0008961_abnormal_basal_metabolism1.48437028
32MP0005319_abnormal_enzyme/_coenzyme1.42433225
33MP0003806_abnormal_nucleotide_metabolis1.41015866
34MP0005551_abnormal_eye_electrophysiolog1.39360147
35MP0005423_abnormal_somatic_nervous1.37611871
36MP0003300_gastrointestinal_ulcer1.37464054
37MP0001986_abnormal_taste_sensitivity1.35871059
38MP0002928_abnormal_bile_duct1.34191077
39MP0005253_abnormal_eye_physiology1.31366306
40MP0002168_other_aberrant_phenotype1.25063925
41MP0005451_abnormal_body_composition1.21837546
42MP0006036_abnormal_mitochondrial_physio1.20905920
43MP0002876_abnormal_thyroid_physiology1.18875098
44MP0005670_abnormal_white_adipose1.13121315
45MP0002089_abnormal_postnatal_growth/wei1.12395111
46MP0000230_abnormal_systemic_arterial1.11196059
47MP0004147_increased_porphyrin_level1.09031335
48MP0003172_abnormal_lysosome_physiology1.08057646
49MP0002896_abnormal_bone_mineralization1.06347269
50MP0002135_abnormal_kidney_morphology1.05045319
51MP0005535_abnormal_body_temperature1.03366264
52MP0008872_abnormal_physiological_respon1.02972854
53MP0005666_abnormal_adipose_tissue1.02525288
54MP0003283_abnormal_digestive_organ0.90870331
55MP0004264_abnormal_extraembryonic_tissu0.89556881
56MP0002118_abnormal_lipid_homeostasis0.89136969
57MP0001764_abnormal_homeostasis0.88415535
58MP0001666_abnormal_nutrient_absorption0.87148467
59MP0000747_muscle_weakness0.83557360
60MP0001502_abnormal_circadian_rhythm0.82830237
61MP0001968_abnormal_touch/_nociception0.78601166
62MP0003638_abnormal_response/metabolism_0.78475565
63MP0002272_abnormal_nervous_system0.78332085
64MP0003646_muscle_fatigue0.78066403
65MP0009642_abnormal_blood_homeostasis0.75958553
66MP0003191_abnormal_cellular_cholesterol0.75152917
67MP0009764_decreased_sensitivity_to0.70369181
68MP0000371_diluted_coat_color0.68682557
69MP0001485_abnormal_pinna_reflex0.68089347
70MP0002796_impaired_skin_barrier0.66014919
71MP0010234_abnormal_vibrissa_follicle0.66013808
72MP0003879_abnormal_hair_cell0.65339197
73MP0001661_extended_life_span0.64541470
74MP0003329_amyloid_beta_deposits0.64191169
75MP0001324_abnormal_eye_pigmentation0.63312298
76MP0000609_abnormal_liver_physiology0.62924134
77MP0003690_abnormal_glial_cell0.62819542
78MP0008569_lethality_at_weaning0.62192879
79MP0005220_abnormal_exocrine_pancreas0.62180328
80MP0009046_muscle_twitch0.60599106
81MP0001501_abnormal_sleep_pattern0.59420227
82MP0010329_abnormal_lipoprotein_level0.59397348
83MP0003136_yellow_coat_color0.59262893
84MP0001486_abnormal_startle_reflex0.59087347
85MP0002115_abnormal_skeleton_extremities0.58363618
86MP0005395_other_phenotype0.57815850
87MP0002064_seizures0.57544742
88MP0000678_abnormal_parathyroid_gland0.56804221
89MP0004858_abnormal_nervous_system0.55492698
90MP0000026_abnormal_inner_ear0.55205616
91MP0000598_abnormal_liver_morphology0.55034303
92MP0002229_neurodegeneration0.54141003
93MP0008469_abnormal_protein_level0.53309812
94MP0005501_abnormal_skin_physiology0.52876465
95MP0002736_abnormal_nociception_after0.50974238
96MP0002998_abnormal_bone_remodeling0.49641267
97MP0005167_abnormal_blood-brain_barrier0.49617602
98MP0005386_behavior/neurological_phenoty0.49139134
99MP0004924_abnormal_behavior0.49139134
100MP0004742_abnormal_vestibular_system0.49078152
101MP0003938_abnormal_ear_development0.47642585
102MP0009745_abnormal_behavioral_response0.47362168
103MP0005165_increased_susceptibility_to0.47186074
104MP0010368_abnormal_lymphatic_system0.47077461
105MP0003635_abnormal_synaptic_transmissio0.46843952
106MP0000631_abnormal_neuroendocrine_gland0.46763429
107MP0003045_fibrosis0.46651660
108MP0002078_abnormal_glucose_homeostasis0.46583807
109MP0003953_abnormal_hormone_level0.46481250
110MP0006035_abnormal_mitochondrial_morpho0.45490751
111MP0003795_abnormal_bone_structure0.45389465
112MP0001970_abnormal_pain_threshold0.44625405
113MP0005408_hypopigmentation0.44531765
114MP0002063_abnormal_learning/memory/cond0.44321179
115MP0005375_adipose_tissue_phenotype0.43848654
116MP0000163_abnormal_cartilage_morphology0.43424614
117MP0002069_abnormal_eating/drinking_beha0.43087085
118MP0003959_abnormal_lean_body0.42272418
119MP0002067_abnormal_sensory_capabilities0.40627905
120MP0005391_vision/eye_phenotype0.40381583
121MP0004859_abnormal_synaptic_plasticity0.39492365
122MP0001944_abnormal_pancreas_morphology0.39001567
123MP0001663_abnormal_digestive_system0.38857298
124MP0009672_abnormal_birth_weight0.38503011
125MP0004272_abnormal_basement_membrane0.38412999
126MP0002735_abnormal_chemical_nociception0.38060015
127MP0002734_abnormal_mechanical_nocicepti0.37452633
128MP0001346_abnormal_lacrimal_gland0.36694568
129MP0009780_abnormal_chondrocyte_physiolo0.35418035
130MP0001963_abnormal_hearing_physiology0.35004156
131MP0002572_abnormal_emotion/affect_behav0.34908914
132MP0003631_nervous_system_phenotype0.34908587
133MP0004130_abnormal_muscle_cell0.34509821
134MP0005195_abnormal_posterior_eye0.34430757
135MP0004484_altered_response_of0.34355080
136MP0002098_abnormal_vibrissa_morphology0.34274033
137MP0009115_abnormal_fat_cell0.34191831
138MP0005646_abnormal_pituitary_gland0.33673617
139MP0001731_abnormal_postnatal_growth0.33545412
140MP0001177_atelectasis0.33500369
141MP0003123_paternal_imprinting0.33301748
142MP0000003_abnormal_adipose_tissue0.33075472
143MP0000920_abnormal_myelination0.32456333
144MP0003633_abnormal_nervous_system0.31676881
145MP0010386_abnormal_urinary_bladder0.31337276
146MP0003221_abnormal_cardiomyocyte_apopto0.29363576
147MP0003075_altered_response_to0.28916029
148MP0002113_abnormal_skeleton_development0.28738359
149MP0002971_abnormal_brown_adipose0.28391711

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.40259213
2Hypokalemic alkalosis (HP:0001949)6.89439717
3Gout (HP:0001997)6.85292875
4Metabolic alkalosis (HP:0200114)6.83048879
5Hypomagnesemia (HP:0002917)6.38569829
6Polyuria (HP:0000103)6.36006609
7Hyperactive renin-angiotensin system (HP:0000841)6.32614615
8Abnormal urine output (HP:0012590)5.95263085
9Abnormality of chloride homeostasis (HP:0011422)5.92415675
10Abnormality of renal excretion (HP:0011036)5.79937451
11Proximal tubulopathy (HP:0000114)5.66801215
12Abnormality of magnesium homeostasis (HP:0004921)5.40678105
13Abnormal drinking behavior (HP:0030082)5.12110842
14Polydipsia (HP:0001959)5.12110842
15Increased purine levels (HP:0004368)4.81950682
16Hyperuricemia (HP:0002149)4.81950682
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.71145420
18Hyperglycinuria (HP:0003108)4.60262860
19Alkalosis (HP:0001948)4.57187770
20Abnormality of renin-angiotensin system (HP:0000847)4.55095528
21Abnormality of purine metabolism (HP:0004352)4.50622309
22Generalized aminoaciduria (HP:0002909)4.48224571
23Renal salt wasting (HP:0000127)4.39249792
24Hyperaldosteronism (HP:0000859)4.32450910
25Tetany (HP:0001281)4.28229564
26Hypercalciuria (HP:0002150)4.13879032
27Abnormality of urine glucose concentration (HP:0011016)3.89922725
28Glycosuria (HP:0003076)3.89922725
29Abnormality of serine family amino acid metabolism (HP:0010894)3.80283425
30Abnormality of glycine metabolism (HP:0010895)3.80283425
31Renal tubular acidosis (HP:0001947)3.57001040
32Ketoacidosis (HP:0001993)3.56152166
33Large eyes (HP:0001090)3.49027232
34Hyperphosphaturia (HP:0003109)3.47726579
35Hypokalemia (HP:0002900)3.47348210
36Delayed epiphyseal ossification (HP:0002663)3.44082894
37Abnormality of nucleobase metabolism (HP:0010932)3.34044852
38Abnormal urine phosphate concentration (HP:0012599)3.27692541
39Ketosis (HP:0001946)3.26106566
40Hydroxyprolinuria (HP:0003080)3.17954583
41Abnormality of proline metabolism (HP:0010907)3.17954583
42Nephrocalcinosis (HP:0000121)3.04472462
43Abnormality of potassium homeostasis (HP:0011042)2.94507567
44Nephrolithiasis (HP:0000787)2.93128478
45Vascular calcification (HP:0004934)2.92564337
46Hypophosphatemia (HP:0002148)2.92186989
47Metaphyseal cupping (HP:0003021)2.78721730
48Rickets (HP:0002748)2.78070452
49Vacuolated lymphocytes (HP:0001922)2.76607608
50Generalized muscle weakness (HP:0003324)2.76124884
51Delayed CNS myelination (HP:0002188)2.71929151
52Hyperglycinemia (HP:0002154)2.67278316
53Abnormality of aspartate family amino acid metabolism (HP:0010899)2.67064544
54Cardiovascular calcification (HP:0011915)2.61485896
55Widely patent fontanelles and sutures (HP:0004492)2.59119829
56Abnormality of fatty-acid metabolism (HP:0004359)2.54080263
57Abnormal enzyme/coenzyme activity (HP:0012379)2.44598416
58Hyperammonemia (HP:0001987)2.43438937
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41233264
60Dicarboxylic aciduria (HP:0003215)2.41233264
61Abnormality of renal resorption (HP:0011038)2.40093161
62Confusion (HP:0001289)2.39166591
63Dehydration (HP:0001944)2.38793402
64Abnormality of alkaline phosphatase activity (HP:0004379)2.37948119
65Thin bony cortex (HP:0002753)2.36021442
66Enlarged kidneys (HP:0000105)2.31650677
67Hypotension (HP:0002615)2.30635099
68Abnormality of Sharpey fibers (HP:0100685)2.26035491
69Hyponatremia (HP:0002902)2.25008335
70Vomiting (HP:0002013)2.24347884
71Malnutrition (HP:0004395)2.23869188
72Abnormality of sodium homeostasis (HP:0010931)2.23595704
73Metabolic acidosis (HP:0001942)2.22663985
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21582423
75Methylmalonic aciduria (HP:0012120)2.19105977
76Abnormal tarsal ossification (HP:0008369)2.18154114
77Renal tubular dysfunction (HP:0000124)2.18105830
78Bilateral sensorineural hearing impairment (HP:0008619)2.08735562
79Lymphangioma (HP:0100764)2.03919093
80Lethargy (HP:0001254)2.02853828
81Sensorimotor neuropathy (HP:0007141)2.02093504
82Abnormality of the costochondral junction (HP:0000919)2.01223384
83Abnormality of sulfur amino acid metabolism (HP:0004339)1.98809387
84Adrenal overactivity (HP:0002717)1.96738660
85Bicornuate uterus (HP:0000813)1.95537722
86Metaphyseal irregularity (HP:0003025)1.93791459
87Tubulointerstitial fibrosis (HP:0005576)1.93205126
88Elevated alkaline phosphatase (HP:0003155)1.90932647
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88642102
90Potter facies (HP:0002009)1.87586278
91Facial shape deformation (HP:0011334)1.87586278
92Irritability (HP:0000737)1.86118722
93Metaphyseal dysplasia (HP:0100255)1.84506577
94Chondrocalcinosis (HP:0000934)1.78280571
95Nausea (HP:0002018)1.77451068
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75697053
97Late onset (HP:0003584)1.73364673
98Tubular atrophy (HP:0000092)1.73349392
99Neonatal onset (HP:0003623)1.71783449
100Abnormality of carpal bone ossification (HP:0006257)1.70958473
101Tachypnea (HP:0002789)1.70949443
102Decreased circulating renin level (HP:0003351)1.70134991
103Glomerulosclerosis (HP:0000096)1.69869012
104Abnormality of serum amino acid levels (HP:0003112)1.68449746
105Dysostosis multiplex (HP:0000943)1.66873636
106Decreased central vision (HP:0007663)1.57016628
107Abnormality of the renal medulla (HP:0100957)1.56492252
108Action tremor (HP:0002345)1.53548909
109Scotoma (HP:0000575)1.53267427
110Nephrogenic diabetes insipidus (HP:0009806)1.50202258
111Attenuation of retinal blood vessels (HP:0007843)1.43659556
112Paresthesia (HP:0003401)1.40903623
113Hyperkalemia (HP:0002153)1.38352200
114Choroideremia (HP:0001139)1.36822168
115Premature birth (HP:0001622)1.29091335
116Focal segmental glomerulosclerosis (HP:0000097)1.28853777
117Ulnar claw (HP:0001178)1.28836173
118Abnormal platelet function (HP:0011869)1.28229406
119Impaired platelet aggregation (HP:0003540)1.28229406
120Congenital stationary night blindness (HP:0007642)1.27443347
121Abnormality of macular pigmentation (HP:0008002)1.23253636
122Macular degeneration (HP:0000608)1.20543898
123Osteopenia (HP:0000938)1.15201260
124Abnormality of the fovea (HP:0000493)1.14808299
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.10423275
126Abnormality of alanine metabolism (HP:0010916)1.10423275
127Hyperalaninemia (HP:0003348)1.10423275
128Tubulointerstitial abnormality (HP:0001969)1.10245304
129Dysdiadochokinesis (HP:0002075)1.06264109
130Peripheral hypomyelination (HP:0007182)1.05699153
131Bony spicule pigmentary retinopathy (HP:0007737)1.00924763
132Intellectual disability, moderate (HP:0002342)1.00530109
133Hypothermia (HP:0002045)0.99716750
134Abnormality of calcium-phosphate metabolism (HP:0100530)0.99022006
135Segmental peripheral demyelination/remyelination (HP:0003481)0.97722683
136Abnormality of the renal cortex (HP:0011035)0.91704571
137Thyroid-stimulating hormone excess (HP:0002925)0.88778438
138Chorioretinal atrophy (HP:0000533)0.88049515
139Enlarged epiphyses (HP:0010580)0.85234343
140Abnormal eating behavior (HP:0100738)0.84907100
141Abnormal rod and cone electroretinograms (HP:0008323)0.84149770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK49.53139006
2OXSR17.13321921
3WNK37.11249194
4STK394.59610136
5BCKDK3.37732416
6STK38L2.62689092
7NEK12.19161084
8WNK12.16040054
9PDK32.10068116
10PDK42.10068116
11CCNB11.90034603
12SGK2231.86882228
13SGK4941.86882228
14STK381.54878034
15PDK21.38695011
16CAMKK21.34299996
17NEK21.28703874
18MST1R1.23517966
19MST41.14180119
20FGFR41.09936137
21GRK11.03468917
22LRRK21.03377316
23EPHB10.95894121
24GRK60.92992449
25SGK30.92606076
26CAMK1D0.90524157
27PINK10.90182512
28SGK20.88642279
29GSK3A0.81117128
30TAF10.75476038
31DYRK1B0.73651570
32NTRK30.72140892
33MAP3K70.67097090
34SGK10.64534482
35CAMKK10.63820352
36PTK20.62857150
37PAK40.55937503
38ABL20.52194714
39PTK60.50487293
40MAP3K30.50351092
41TGFBR20.50346689
42MAPK110.49100242
43TIE10.48668011
44PRKAA10.47170232
45PDPK10.47049515
46ERN10.46693037
47TRIB30.46344759
48SMG10.46180602
49AKT30.43731357
50PAK30.41620670
51INSRR0.39081521
52PRKCI0.37412252
53PTK2B0.37341752
54PRKAA20.36430638
55STK110.35599364
56MET0.35141072
57FER0.35065565
58PRKD20.34528413
59PRKCZ0.33431165
60PDK10.32756146
61STK100.32707022
62NTRK10.31706071
63CAMK10.30624024
64RIPK10.30533811
65TNIK0.29451659
66YES10.26919648
67UHMK10.26071120
68MINK10.25800663
69TGFBR10.25440767
70MAP3K20.24508975
71IRAK20.23682202
72EPHA40.23662797
73ADRBK20.23434982
74CSNK1A10.22434988
75ADRBK10.22269609
76HIPK20.22176656
77CHUK0.22072677
78PRKCH0.21990534
79PRKCD0.21749196
80FRK0.21562975
81GRK50.21282226
82PRKACG0.20930743
83ERBB40.19373518
84MAPKAPK50.19098271
85PAK60.19005492
86BLK0.18849920
87MYLK0.18522660
88PNCK0.18479865
89BMX0.16897941
90KSR20.16558856
91MAP2K40.16524258
92IRAK30.15698905
93PRKCA0.14903426
94CSF1R0.14838763
95AKT20.14483831
96SYK0.14340016
97NME20.14322719
98CAMK1G0.13971654
99PRKCG0.13799414
100MAPK150.13753891
101LATS10.13464289
102FGR0.13081847
103ERBB20.12668911
104ROCK10.12269736
105PDGFRB0.12079509
106MAP3K140.11982265
107PRKACA0.11788920
108VRK20.10981085
109MAP2K60.10496605
110BMPR1B0.10464848
111PRKG10.10391301
112MARK10.09828265
113PIM10.09660636
114JAK20.09458945
115PRKCE0.09440744
116INSR0.08743502
117MAPK120.08628726
118PRKD30.08441518
119TRPM70.08390570
120SCYL20.08138726
121PHKG10.07467756
122PHKG20.07467756
123IRAK10.07308823
124RET0.07095825
125CAMK2A0.06728205
126MAP2K10.06391375
127CAMK40.06348661
128CAMK2B0.06297229
129ZAP700.06223821
130MAP2K30.06211882
131KIT0.05795684
132MARK20.05658338
133SRC0.05358711
134MUSK0.05180679
135MAPK130.04537704
136DYRK1A0.03971609
137PRKCB0.03755039
138TAOK10.03122456
139FES0.02980587
140MTOR0.02751181
141DAPK20.02693748
142RPS6KA30.02332982
143NME10.02232004
144PRKCQ0.02089759
145CSK0.02040552
146MAPK40.01908328
147ROCK20.01686537
148PRKACB0.01415130
149CDK50.01115775
150MAP3K110.01014488
151PDGFRA-0.0093595

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.08681178
2Butanoate metabolism_Homo sapiens_hsa006503.82894577
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.55881747
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.50884215
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.39871300
6Pentose and glucuronate interconversions_Homo sapiens_hsa000403.15797100
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.11632269
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.99888000
9Propanoate metabolism_Homo sapiens_hsa006402.95652670
10Phototransduction_Homo sapiens_hsa047442.89392770
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.51166569
12Pyruvate metabolism_Homo sapiens_hsa006202.49068529
13Peroxisome_Homo sapiens_hsa041462.42325695
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37972043
15Fatty acid degradation_Homo sapiens_hsa000712.27583122
16Collecting duct acid secretion_Homo sapiens_hsa049662.16607959
17Tryptophan metabolism_Homo sapiens_hsa003802.12576512
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10824610
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.06407477
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03515230
21Vitamin digestion and absorption_Homo sapiens_hsa049772.00189380
22beta-Alanine metabolism_Homo sapiens_hsa004101.83344588
23Sulfur metabolism_Homo sapiens_hsa009201.77713554
24Fatty acid metabolism_Homo sapiens_hsa012121.72747907
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68149858
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63276596
27Carbon metabolism_Homo sapiens_hsa012001.61814206
28Bile secretion_Homo sapiens_hsa049761.58272561
29Glutathione metabolism_Homo sapiens_hsa004801.51818395
30Arginine and proline metabolism_Homo sapiens_hsa003301.48911778
31Nicotine addiction_Homo sapiens_hsa050331.40546720
32Other glycan degradation_Homo sapiens_hsa005111.31337436
33Caffeine metabolism_Homo sapiens_hsa002321.31103883
34Starch and sucrose metabolism_Homo sapiens_hsa005001.30027214
35Lysine degradation_Homo sapiens_hsa003101.21581863
36Mineral absorption_Homo sapiens_hsa049781.21572491
37Protein digestion and absorption_Homo sapiens_hsa049741.21409773
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.18911405
39Arginine biosynthesis_Homo sapiens_hsa002201.17013703
40GABAergic synapse_Homo sapiens_hsa047271.14035585
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11939065
42PPAR signaling pathway_Homo sapiens_hsa033201.11013347
43Nitrogen metabolism_Homo sapiens_hsa009101.10982589
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08484811
45Histidine metabolism_Homo sapiens_hsa003401.07229567
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04792661
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03475265
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02235580
49Selenocompound metabolism_Homo sapiens_hsa004500.98927778
50Gap junction_Homo sapiens_hsa045400.96055697
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94173616
52Calcium signaling pathway_Homo sapiens_hsa040200.92960428
53Phenylalanine metabolism_Homo sapiens_hsa003600.92500188
54Morphine addiction_Homo sapiens_hsa050320.91681580
55Glycerolipid metabolism_Homo sapiens_hsa005610.90670702
56Biosynthesis of amino acids_Homo sapiens_hsa012300.90005032
57Folate biosynthesis_Homo sapiens_hsa007900.89937074
58Bladder cancer_Homo sapiens_hsa052190.88716805
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88015907
60Glutamatergic synapse_Homo sapiens_hsa047240.87108573
61Taste transduction_Homo sapiens_hsa047420.84787366
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83818090
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.82704085
64Complement and coagulation cascades_Homo sapiens_hsa046100.82236753
65FoxO signaling pathway_Homo sapiens_hsa040680.79219673
66Fructose and mannose metabolism_Homo sapiens_hsa000510.77370760
67Endometrial cancer_Homo sapiens_hsa052130.71818925
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.71562402
69Glioma_Homo sapiens_hsa052140.70184178
70Insulin secretion_Homo sapiens_hsa049110.69374690
71ErbB signaling pathway_Homo sapiens_hsa040120.69231832
72Circadian entrainment_Homo sapiens_hsa047130.68489482
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68171081
74Non-small cell lung cancer_Homo sapiens_hsa052230.66861739
75Linoleic acid metabolism_Homo sapiens_hsa005910.63762441
76Lysosome_Homo sapiens_hsa041420.63560109
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.63383413
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.63153721
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.62823054
80Pentose phosphate pathway_Homo sapiens_hsa000300.61798635
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.61622846
82Oxidative phosphorylation_Homo sapiens_hsa001900.60845050
83Fatty acid elongation_Homo sapiens_hsa000620.60832675
84Salivary secretion_Homo sapiens_hsa049700.60359810
85Melanoma_Homo sapiens_hsa052180.59523838
86Long-term depression_Homo sapiens_hsa047300.59122641
87Chemical carcinogenesis_Homo sapiens_hsa052040.57092322
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56737242
89Thyroid hormone synthesis_Homo sapiens_hsa049180.56040653
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53470916
91Renin-angiotensin system_Homo sapiens_hsa046140.52656835
92Gastric acid secretion_Homo sapiens_hsa049710.51135732
93Metabolic pathways_Homo sapiens_hsa011000.50251709
94cAMP signaling pathway_Homo sapiens_hsa040240.49721507
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48354770
96Retinol metabolism_Homo sapiens_hsa008300.47640268
97Steroid biosynthesis_Homo sapiens_hsa001000.43843177
98Renin secretion_Homo sapiens_hsa049240.42705692
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.40887577
100Ether lipid metabolism_Homo sapiens_hsa005650.39904591
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38131187
102Olfactory transduction_Homo sapiens_hsa047400.37596283
103Long-term potentiation_Homo sapiens_hsa047200.36157345
104Focal adhesion_Homo sapiens_hsa045100.35654438
105Arachidonic acid metabolism_Homo sapiens_hsa005900.35520317
106Synaptic vesicle cycle_Homo sapiens_hsa047210.35408204
107Vibrio cholerae infection_Homo sapiens_hsa051100.34105646
108Staphylococcus aureus infection_Homo sapiens_hsa051500.33809492
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32519198
110Parkinsons disease_Homo sapiens_hsa050120.29642810
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27659935
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27347751
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26499256
114Serotonergic synapse_Homo sapiens_hsa047260.25778935
115Prostate cancer_Homo sapiens_hsa052150.25527699
116ABC transporters_Homo sapiens_hsa020100.24755274
117Tyrosine metabolism_Homo sapiens_hsa003500.24096901
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22141731
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22119220
120Choline metabolism in cancer_Homo sapiens_hsa052310.21420024
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19028066
122Sphingolipid metabolism_Homo sapiens_hsa006000.16269329
123Sulfur relay system_Homo sapiens_hsa041220.16138629
124Cardiac muscle contraction_Homo sapiens_hsa042600.11083153
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.07108407
126Insulin resistance_Homo sapiens_hsa049310.07046187
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.06842404
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06365573
129Inositol phosphate metabolism_Homo sapiens_hsa005620.04261563
130Alzheimers disease_Homo sapiens_hsa050100.02934934
131Rheumatoid arthritis_Homo sapiens_hsa053230.02230785
132Galactose metabolism_Homo sapiens_hsa000520.01593400
133AMPK signaling pathway_Homo sapiens_hsa041520.01469731
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.01326320
135Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0864609
136Pancreatic secretion_Homo sapiens_hsa04972-0.0847837
137Huntingtons disease_Homo sapiens_hsa05016-0.0763267
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0678270
139One carbon pool by folate_Homo sapiens_hsa00670-0.0587341
140Glucagon signaling pathway_Homo sapiens_hsa04922-0.0201287

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »