SLC22A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)9.53342726
2protein-chromophore linkage (GO:0018298)9.51038324
3aminoglycoside antibiotic metabolic process (GO:0030647)9.25977424
4drug transmembrane transport (GO:0006855)8.72200694
5detection of light stimulus involved in visual perception (GO:0050908)8.38039493
6detection of light stimulus involved in sensory perception (GO:0050962)8.38039493
7cellular response to electrical stimulus (GO:0071257)7.74160926
8drug transport (GO:0015893)7.24566596
9organic cation transport (GO:0015695)7.05789174
10actin filament depolymerization (GO:0030042)6.94163371
11phosphate ion transport (GO:0006817)6.74990255
12response to mercury ion (GO:0046689)6.17893531
13lysine metabolic process (GO:0006553)6.14010960
14lysine catabolic process (GO:0006554)6.14010960
15collecting duct development (GO:0072044)6.09376119
16drug catabolic process (GO:0042737)5.59737922
17cardiovascular system development (GO:0072358)5.49014131
18phosphate ion transmembrane transport (GO:0035435)5.44156328
19regulation of rhodopsin mediated signaling pathway (GO:0022400)5.42470397
20exogenous drug catabolic process (GO:0042738)5.42191855
21renal absorption (GO:0070293)5.41208451
22fat-soluble vitamin metabolic process (GO:0006775)5.34307579
23excretion (GO:0007588)5.32533836
24sodium-independent organic anion transport (GO:0043252)5.32411071
25glyoxylate metabolic process (GO:0046487)5.20022287
26cell volume homeostasis (GO:0006884)5.15967212
27vitamin transmembrane transport (GO:0035461)5.06867858
28retinal metabolic process (GO:0042574)5.05684206
29rhodopsin mediated signaling pathway (GO:0016056)4.97533066
30fat-soluble vitamin biosynthetic process (GO:0042362)4.87783771
31phototransduction, visible light (GO:0007603)4.76488467
32* quaternary ammonium group transport (GO:0015697)4.74542670
33tricarboxylic acid metabolic process (GO:0072350)4.71506209
34positive regulation of catenin import into nucleus (GO:0035413)4.71200255
35response to water (GO:0009415)4.70344530
36short-chain fatty acid metabolic process (GO:0046459)4.64428599
37phototransduction (GO:0007602)4.64030590
38metanephric tubule development (GO:0072170)4.62177881
39metanephric nephron tubule development (GO:0072234)4.62177881
40phosphate ion homeostasis (GO:0055062)4.59946970
41trivalent inorganic anion homeostasis (GO:0072506)4.59946970
42vitamin D metabolic process (GO:0042359)4.56707027
43cell-cell junction maintenance (GO:0045217)4.54494105
44cysteine metabolic process (GO:0006534)4.48161527
45retinol metabolic process (GO:0042572)4.46484512
46activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.45524075
47endothelium development (GO:0003158)4.42865869
48metanephric nephron epithelium development (GO:0072243)4.42610554
49detection of light stimulus (GO:0009583)4.37894566
50response to lead ion (GO:0010288)4.32385177
51detection of visible light (GO:0009584)4.31211655
52response to thyroid hormone (GO:0097066)4.29126065
53nonribosomal peptide biosynthetic process (GO:0019184)4.29023649
54lymph vessel development (GO:0001945)4.28413078
55positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.28407242
56positive regulation of guanylate cyclase activity (GO:0031284)4.27159680
57gamma-aminobutyric acid transport (GO:0015812)4.19631272
58vitamin transport (GO:0051180)4.14132070
59peptidyl-tyrosine autophosphorylation (GO:0038083)4.13576889
60metanephric epithelium development (GO:0072207)4.11050078
61aspartate family amino acid catabolic process (GO:0009068)4.08582941
62toxin transport (GO:1901998)4.06087406
63regulation of guanylate cyclase activity (GO:0031282)3.97951793
64vascular endothelial growth factor signaling pathway (GO:0038084)3.97317012
65branched-chain amino acid metabolic process (GO:0009081)3.97266396
66positive regulation of dendritic spine morphogenesis (GO:0061003)3.94871793
67negative regulation of sterol transport (GO:0032372)3.94256536
68negative regulation of cholesterol transport (GO:0032375)3.94256536
69surfactant homeostasis (GO:0043129)3.91520875
70regulation of apoptotic process involved in morphogenesis (GO:1902337)3.91371910
71homocysteine metabolic process (GO:0050667)3.88667034
72positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.88610181
73mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.87129933
74cell junction maintenance (GO:0034331)3.81412185
75negative regulation of metanephros development (GO:0072217)3.81019724
76amino-acid betaine transport (GO:0015838)3.79720006
77carnitine transport (GO:0015879)3.79720006
78nephron tubule development (GO:0072080)3.77300992
79glutathione biosynthetic process (GO:0006750)3.73112708
80polyol transport (GO:0015791)3.70492322
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.69672618
82L-phenylalanine metabolic process (GO:0006558)3.69672618
83erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.63307421
84L-phenylalanine catabolic process (GO:0006559)3.63307421
85response to copper ion (GO:0046688)3.62914183
86glycoside metabolic process (GO:0016137)3.62246458
87fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.62186020
88valine metabolic process (GO:0006573)3.61577496
89aromatic amino acid family catabolic process (GO:0009074)3.60809694
90retinoid metabolic process (GO:0001523)3.59776055
91visual perception (GO:0007601)3.56282356
92proline metabolic process (GO:0006560)3.54929395
93regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.53832209
94positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.53333814
95sensory perception of light stimulus (GO:0050953)3.52109099
96cellular modified amino acid catabolic process (GO:0042219)3.51393333
97nephron epithelium development (GO:0072009)3.49322616
98tryptophan catabolic process (GO:0006569)3.46430420
99indole-containing compound catabolic process (GO:0042436)3.46430420
100indolalkylamine catabolic process (GO:0046218)3.46430420
101* modified amino acid transport (GO:0072337)3.43352200
102renal system process (GO:0003014)3.42648249
103short-term memory (GO:0007614)3.41205988
104fatty acid beta-oxidation (GO:0006635)3.37418858
105diterpenoid metabolic process (GO:0016101)3.35785807
106cellular response to vitamin D (GO:0071305)3.33570315
107keratan sulfate catabolic process (GO:0042340)3.32428761
108branched-chain amino acid catabolic process (GO:0009083)3.29876331
109renal tubule development (GO:0061326)3.28018397
110positive regulation of ERBB signaling pathway (GO:1901186)3.27143249
111fructose metabolic process (GO:0006000)3.26521187
112serine family amino acid catabolic process (GO:0009071)3.26001295
113nephron tubule formation (GO:0072079)3.25258981
114tryptophan metabolic process (GO:0006568)3.25222148
115Notch signaling involved in heart development (GO:0061314)3.25166690
116detection of external stimulus (GO:0009581)3.21850284
117inositol metabolic process (GO:0006020)3.21260803
118cellular ketone body metabolic process (GO:0046950)3.19451252
119oligosaccharide catabolic process (GO:0009313)3.19132416
120regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.17230890
121response to parathyroid hormone (GO:0071107)3.17088313
122amino-acid betaine metabolic process (GO:0006577)3.16020829
123amine catabolic process (GO:0009310)3.10630583
124cellular biogenic amine catabolic process (GO:0042402)3.10630583
125peptide biosynthetic process (GO:0043043)3.10057564
126detection of abiotic stimulus (GO:0009582)3.10002621
127chemical homeostasis within a tissue (GO:0048875)3.09575920
128nephron epithelium morphogenesis (GO:0072088)3.08691758
129nephron tubule morphogenesis (GO:0072078)3.08691758
130bone remodeling (GO:0046849)3.08496629
131* sulfur compound transport (GO:0072348)3.08341004
132sodium ion transport (GO:0006814)3.06150110
133hyperosmotic response (GO:0006972)3.05764850
134fatty acid oxidation (GO:0019395)3.05616685
135cellular potassium ion homeostasis (GO:0030007)3.05254700
136regulation of catenin import into nucleus (GO:0035412)3.03528655
137glutamate metabolic process (GO:0006536)3.01987345
138lipid oxidation (GO:0034440)3.00203621
139serine family amino acid metabolic process (GO:0009069)2.99758064
140regulation of protein localization to cell surface (GO:2000008)2.97010099
141response to growth hormone (GO:0060416)2.95349080
142glomerular visceral epithelial cell development (GO:0072015)2.93351858
143L-ascorbic acid metabolic process (GO:0019852)2.90719193
144ERK1 and ERK2 cascade (GO:0070371)2.90601668
145response to vitamin A (GO:0033189)2.90388634
146positive regulation of cGMP biosynthetic process (GO:0030828)2.89592150
147terpenoid metabolic process (GO:0006721)2.89459601
148carnitine metabolic process (GO:0009437)2.89383487
149negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.88637698
150glutamine family amino acid catabolic process (GO:0009065)2.88360919
151response to pheromone (GO:0019236)2.87661978
152acetyl-CoA metabolic process (GO:0006084)2.87655104
153response to magnesium ion (GO:0032026)2.87404971
154response to electrical stimulus (GO:0051602)2.86638813
155indole-containing compound metabolic process (GO:0042430)2.86270985
1562-oxoglutarate metabolic process (GO:0006103)2.85288757
157renal tubule morphogenesis (GO:0061333)2.83953137
158pattern specification involved in kidney development (GO:0061004)2.81464421
159cellular amino acid catabolic process (GO:0009063)2.80373179
160beta-amyloid metabolic process (GO:0050435)2.78467517
161regulation of cGMP biosynthetic process (GO:0030826)2.78385460
162peptide catabolic process (GO:0043171)2.77001851
163fatty acid catabolic process (GO:0009062)2.76458876
164alpha-amino acid catabolic process (GO:1901606)2.73762638
165negative regulation of cardiac muscle tissue growth (GO:0055022)2.67909790
166negative regulation of heart growth (GO:0061117)2.67909790
167cellular response to ammonium ion (GO:0071242)2.66739875
168regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:22.58469295
169L-methionine salvage (GO:0071267)2.58420749
170L-methionine biosynthetic process (GO:0071265)2.58420749
171amino acid salvage (GO:0043102)2.58420749
172regulation of cGMP metabolic process (GO:0030823)2.56432474
173glomerular epithelial cell development (GO:0072310)2.54796884
174neuronal action potential propagation (GO:0019227)2.53287837
175regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.52762200
176vitamin A metabolic process (GO:0006776)18.8549123

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.22545734
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.02931010
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.82948948
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.24228896
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.24132623
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.22403629
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.13187207
8GBX2_23144817_ChIP-Seq_PC3_Human2.12876407
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08208820
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.04311315
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.01661011
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00787312
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.94654075
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93522116
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91197284
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.91103539
17IGF1R_20145208_ChIP-Seq_DFB_Human1.90261242
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88360617
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88360617
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87347011
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79968296
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.79275634
23PPARA_22158963_ChIP-Seq_LIVER_Mouse1.77571841
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71385427
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.71111138
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.61479053
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60277449
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59292523
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.59138183
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.57018269
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.56018055
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55542522
33AR_21572438_ChIP-Seq_LNCaP_Human1.51506288
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.50663136
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50492441
36RXR_22108803_ChIP-Seq_LS180_Human1.48551155
37SMAD3_21741376_ChIP-Seq_HESCs_Human1.47525546
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47201416
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44865298
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44461610
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43832367
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38750080
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38331047
44VDR_22108803_ChIP-Seq_LS180_Human1.37454635
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37076606
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33440983
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31141364
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30560297
49* CBP_21632823_ChIP-Seq_H3396_Human1.29139454
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28509095
51FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27433752
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.27292723
53PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25246435
54SMAD4_21741376_ChIP-Seq_HESCs_Human1.24697612
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24258076
56MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22528575
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.22507320
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20422688
59BCAT_22108803_ChIP-Seq_LS180_Human1.19358210
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.17586154
61TBL1_22424771_ChIP-Seq_293T_Human1.17520658
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16531358
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.16425306
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16112394
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14921369
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14149249
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13839420
68TCF4_22108803_ChIP-Seq_LS180_Human1.13816311
69AHR_22903824_ChIP-Seq_MCF-7_Human1.13460199
70CLOCK_20551151_ChIP-Seq_293T_Human1.13013741
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11676963
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.11342578
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11342575
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11342575
75VDR_24787735_ChIP-Seq_THP-1_Human1.10260647
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10158602
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09072618
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.08782526
79DROSHA_22980978_ChIP-Seq_HELA_Human1.08488550
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08077941
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07079239
82* PHF8_20622853_ChIP-Seq_HELA_Human1.06894204
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05305276
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04426618
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03297127
86FOXA2_19822575_ChIP-Seq_HepG2_Human1.03188138
87NFYA_21822215_ChIP-Seq_K562_Human1.02618424
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.01871016
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00498792
90SOX2_20726797_ChIP-Seq_SW620_Human0.99513077
91CBX2_27304074_Chip-Seq_ESCs_Mouse0.99329425
92HTT_18923047_ChIP-ChIP_STHdh_Human0.99249879
93CJUN_26792858_Chip-Seq_BT549_Human0.98460733
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98220512
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97821854
96CDX2_22108803_ChIP-Seq_LS180_Human0.97366387
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.97100948
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96259741
99NFYB_21822215_ChIP-Seq_K562_Human0.96249812
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95673160
101RING1B_27294783_Chip-Seq_ESCs_Mouse0.95472996
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94694681
103STAT3_23295773_ChIP-Seq_U87_Human0.94270728
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94022911
105SMAD4_21799915_ChIP-Seq_A2780_Human0.93756968
106BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93752345
107* KDM2B_26808549_Chip-Seq_REH_Human0.93682094
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93648166
109E2F1_18555785_Chip-Seq_ESCs_Mouse0.93458954
110GATA1_19941826_ChIP-Seq_K562_Human0.93421246
111RNF2_27304074_Chip-Seq_ESCs_Mouse0.93366557
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92874873
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92839077
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92311638
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.92183049
116TAF15_26573619_Chip-Seq_HEK293_Human0.92107382
117TCF4_18268006_ChIP-ChIP_LS174T_Human0.91777096
118KLF4_18555785_Chip-Seq_ESCs_Mouse0.90478280
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90348721
120P53_22387025_ChIP-Seq_ESCs_Mouse0.89576290
121SMAD3_21741376_ChIP-Seq_EPCs_Human0.89554219
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89432446
123CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89245259
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88853222
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.88674778
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.88674778
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.88375949
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88326457
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85756012
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85461428
131FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.85221874
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84229901
133AR_25329375_ChIP-Seq_VCAP_Human0.81154765
134TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.79852879
135P300_19829295_ChIP-Seq_ESCs_Human0.79673353
136SOX9_24532713_ChIP-Seq_HFSC_Mouse0.78882854
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77591769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation6.44001597
2MP0005360_urolithiasis6.06578268
3MP0004019_abnormal_vitamin_homeostasis4.99375322
4MP0005332_abnormal_amino_acid4.14017571
5MP0005377_hearing/vestibular/ear_phenot3.69507954
6MP0003878_abnormal_ear_physiology3.69507954
7MP0001765_abnormal_ion_homeostasis3.68906373
8MP0005167_abnormal_blood-brain_barrier3.44968399
9MP0003195_calcinosis3.43388353
10* MP0009643_abnormal_urine_homeostasis3.33443709
11MP0002138_abnormal_hepatobiliary_system3.18411870
12MP0002139_abnormal_hepatobiliary_system3.10419625
13MP0005636_abnormal_mineral_homeostasis3.04687201
14MP0005253_abnormal_eye_physiology3.03909462
15MP0001756_abnormal_urination2.89928654
16* MP0002136_abnormal_kidney_physiology2.63683754
17MP0005551_abnormal_eye_electrophysiolog2.54202339
18MP0001986_abnormal_taste_sensitivity2.53349050
19MP0004147_increased_porphyrin_level2.45167723
20MP0001958_emphysema2.37330120
21MP0005423_abnormal_somatic_nervous2.35832644
22MP0001879_abnormal_lymphatic_vessel2.35656720
23MP0005084_abnormal_gallbladder_morpholo2.27953652
24MP0008875_abnormal_xenobiotic_pharmacok2.11119045
25MP0003011_delayed_dark_adaptation14.5328485
26MP0004885_abnormal_endolymph1.99758763
27MP0008961_abnormal_basal_metabolism1.81250538
28MP0004484_altered_response_of1.73935188
29MP0004272_abnormal_basement_membrane1.67299920
30MP0005670_abnormal_white_adipose1.59519183
31MP0005085_abnormal_gallbladder_physiolo1.56666718
32MP0005365_abnormal_bile_salt1.56440138
33MP0003252_abnormal_bile_duct1.55411006
34MP0001324_abnormal_eye_pigmentation1.54422322
35MP0005165_increased_susceptibility_to1.45174081
36MP0000230_abnormal_systemic_arterial1.41058844
37MP0010368_abnormal_lymphatic_system1.38241763
38MP0005391_vision/eye_phenotype1.31208181
39MP0002928_abnormal_bile_duct1.29635093
40MP0006138_congestive_heart_failure1.23310937
41MP0003300_gastrointestinal_ulcer1.22892003
42MP0000538_abnormal_urinary_bladder1.22171854
43MP0003186_abnormal_redox_activity1.19835406
44MP0005408_hypopigmentation1.19633219
45MP0003724_increased_susceptibility_to1.18998581
46MP0002090_abnormal_vision1.16966763
47MP0005584_abnormal_enzyme/coenzyme_acti1.14516489
48MP0005058_abnormal_lysosome_morphology1.14456383
49MP0001485_abnormal_pinna_reflex1.03872781
50MP0003638_abnormal_response/metabolism_1.03092132
51MP0003045_fibrosis1.02558982
52MP0005409_darkened_coat_color1.00608157
53MP0002896_abnormal_bone_mineralization1.00509546
54MP0004742_abnormal_vestibular_system0.98028502
55MP0002108_abnormal_muscle_morphology0.97186912
56MP0000534_abnormal_ureter_morphology0.96360184
57MP0002229_neurodegeneration0.94572082
58MP0006072_abnormal_retinal_apoptosis0.93928617
59MP0005195_abnormal_posterior_eye0.90737472
60MP0003943_abnormal_hepatobiliary_system0.90079539
61MP0003879_abnormal_hair_cell0.88687096
62MP0002135_abnormal_kidney_morphology0.88673459
63MP0005535_abnormal_body_temperature0.86117205
64MP0005220_abnormal_exocrine_pancreas0.85581694
65MP0002089_abnormal_postnatal_growth/wei0.84135652
66MP0002168_other_aberrant_phenotype0.82730339
67MP0005595_abnormal_vascular_smooth0.81843268
68MP0002876_abnormal_thyroid_physiology0.81172235
69MP0003136_yellow_coat_color0.79243916
70MP0005623_abnormal_meninges_morphology0.78950030
71MP0001873_stomach_inflammation0.77708377
72MP0005319_abnormal_enzyme/_coenzyme0.76778118
73MP0009764_decreased_sensitivity_to0.76395605
74MP0005171_absent_coat_pigmentation0.73812746
75MP0003633_abnormal_nervous_system0.73736469
76MP0003806_abnormal_nucleotide_metabolis0.72670300
77MP0009379_abnormal_foot_pigmentation0.69848656
78MP0005395_other_phenotype0.66595091
79MP0001764_abnormal_homeostasis0.66280470
80MP0001486_abnormal_startle_reflex0.64760079
81MP0008004_abnormal_stomach_pH0.64178907
82MP0002638_abnormal_pupillary_reflex0.63749160
83MP0002098_abnormal_vibrissa_morphology0.63584717
84MP0005666_abnormal_adipose_tissue0.62053255
85MP0001963_abnormal_hearing_physiology0.61089004
86MP0002118_abnormal_lipid_homeostasis0.61041380
87MP0009642_abnormal_blood_homeostasis0.56724558
88MP0001270_distended_abdomen0.56423973
89MP0009278_abnormal_bone_marrow0.56023493
90MP0001177_atelectasis0.55120104
91MP0010386_abnormal_urinary_bladder0.54141400
92MP0006036_abnormal_mitochondrial_physio0.53956743
93MP0000678_abnormal_parathyroid_gland0.52329256
94MP0004215_abnormal_myocardial_fiber0.52262789
95MP0005451_abnormal_body_composition0.51335663
96MP0002998_abnormal_bone_remodeling0.51229161
97MP0010329_abnormal_lipoprotein_level0.50825729
98MP0003690_abnormal_glial_cell0.50688528
99MP0002736_abnormal_nociception_after0.50380635
100MP0005620_abnormal_muscle_contractility0.49957517
101MP0003631_nervous_system_phenotype0.49805293
102MP0003959_abnormal_lean_body0.49527337
103MP0001664_abnormal_digestion0.49227297
104MP0003283_abnormal_digestive_organ0.49106622
105MP0002295_abnormal_pulmonary_circulatio0.48930409
106MP0002064_seizures0.47379952
107MP0002069_abnormal_eating/drinking_beha0.47310382
108MP0002115_abnormal_skeleton_extremities0.46903867
109MP0001663_abnormal_digestive_system0.45403930
110MP0000747_muscle_weakness0.44924689
111MP0002735_abnormal_chemical_nociception0.44736378
112MP0002752_abnormal_somatic_nervous0.44399585
113MP0002734_abnormal_mechanical_nocicepti0.44339067
114MP0000920_abnormal_myelination0.43559285
115MP0001915_intracranial_hemorrhage0.43422708
116MP0002972_abnormal_cardiac_muscle0.43147091
117MP0000569_abnormal_digit_pigmentation0.42957668
118MP0005275_abnormal_skin_tensile0.42695255
119MP0002822_catalepsy0.42457486
120MP0002933_joint_inflammation0.39975664
121MP0005503_abnormal_tendon_morphology0.38731949
122MP0005330_cardiomyopathy0.38500883
123MP0001666_abnormal_nutrient_absorption0.38357094
124MP0000026_abnormal_inner_ear0.38283507
125MP0002272_abnormal_nervous_system0.37572883
126MP0001501_abnormal_sleep_pattern0.35848473
127MP0008872_abnormal_physiological_respon0.35336169
128MP0002075_abnormal_coat/hair_pigmentati0.33872135
129MP0004264_abnormal_extraembryonic_tissu0.32518050
130MP0003646_muscle_fatigue0.30768136
131MP0002882_abnormal_neuron_morphology0.25805345
132MP0003634_abnormal_glial_cell0.24760927
133MP0002249_abnormal_larynx_morphology0.24626871
134MP0001984_abnormal_olfaction0.24546786
135MP0001968_abnormal_touch/_nociception0.24162944
136MP0001346_abnormal_lacrimal_gland0.23316731
137MP0000372_irregular_coat_pigmentation0.23035881
138MP0003938_abnormal_ear_development0.21948875
139MP0003795_abnormal_bone_structure0.19752888
140MP0003329_amyloid_beta_deposits0.19068251
141MP0002971_abnormal_brown_adipose0.18722124
142MP0002067_abnormal_sensory_capabilities0.18601108
143MP0008569_lethality_at_weaning0.17903736
144MP0005197_abnormal_uvea_morphology0.16900774
145MP0003953_abnormal_hormone_level0.16698958

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)8.66084882
2Metabolic alkalosis (HP:0200114)8.09024130
3Hypokalemic alkalosis (HP:0001949)7.91921764
4Hypomagnesemia (HP:0002917)7.60823107
5Hyperactive renin-angiotensin system (HP:0000841)7.24133560
6Polyuria (HP:0000103)6.95079965
7Abnormality of magnesium homeostasis (HP:0004921)6.46966799
8Abnormal urine output (HP:0012590)6.45489434
9Abnormality of chloride homeostasis (HP:0011422)6.38740978
10Decreased electroretinogram (ERG) amplitude (HP:0000654)6.09330457
11Abnormality of renal excretion (HP:0011036)6.04064149
12Gout (HP:0001997)6.01730473
13Abnormal drinking behavior (HP:0030082)5.96348502
14Polydipsia (HP:0001959)5.96348502
15Tetany (HP:0001281)5.78856841
16Abnormality of renin-angiotensin system (HP:0000847)5.28348437
17Alkalosis (HP:0001948)5.05962116
18Hyperaldosteronism (HP:0000859)5.00334779
19Renal salt wasting (HP:0000127)4.94033801
20Proximal tubulopathy (HP:0000114)4.67034741
21Choroideremia (HP:0001139)4.59887919
22Congenital stationary night blindness (HP:0007642)4.58795077
23Increased purine levels (HP:0004368)4.40782226
24Hyperuricemia (HP:0002149)4.40782226
25Scotoma (HP:0000575)4.17389945
26Abnormality of glutamine family amino acid metabolism (HP:0010902)4.13223189
27Decreased central vision (HP:0007663)4.10886309
28Hypercalciuria (HP:0002150)4.02616882
29Hyperglycinuria (HP:0003108)4.00988740
30Hypokalemia (HP:0002900)3.94737172
31Attenuation of retinal blood vessels (HP:0007843)3.93623836
32Abnormality of purine metabolism (HP:0004352)3.86637240
33Generalized aminoaciduria (HP:0002909)3.65190104
34Bony spicule pigmentary retinopathy (HP:0007737)3.38076464
35Abnormality of potassium homeostasis (HP:0011042)3.33173629
36Abnormality of glycine metabolism (HP:0010895)3.32119800
37Abnormality of serine family amino acid metabolism (HP:0010894)3.32119800
38Renal tubular acidosis (HP:0001947)3.29003826
39Abnormality of urine glucose concentration (HP:0011016)3.19293726
40Glycosuria (HP:0003076)3.19293726
41Confusion (HP:0001289)3.16029668
42Ketoacidosis (HP:0001993)3.11923173
43Ulnar claw (HP:0001178)3.07274806
44Macular degeneration (HP:0000608)2.93800297
45Nephrocalcinosis (HP:0000121)2.83730976
46Hydroxyprolinuria (HP:0003080)2.83524573
47Abnormality of proline metabolism (HP:0010907)2.83524573
48Abnormality of the fovea (HP:0000493)2.80906204
49Hyperphosphaturia (HP:0003109)2.78945439
50Abnormality of nucleobase metabolism (HP:0010932)2.75886435
51Ketosis (HP:0001946)2.72050786
52Large eyes (HP:0001090)2.70918403
53Abnormal urine phosphate concentration (HP:0012599)2.70425659
54Delayed epiphyseal ossification (HP:0002663)2.68922707
55Hypoglycemic coma (HP:0001325)2.64386208
56Delayed CNS myelination (HP:0002188)2.57883415
57Peripheral hypomyelination (HP:0007182)2.53776949
58Abnormality of fatty-acid metabolism (HP:0004359)2.51420192
59Central scotoma (HP:0000603)2.50879968
60Abnormal rod and cone electroretinograms (HP:0008323)2.48477196
61Action tremor (HP:0002345)2.47357367
62Abnormal pupillary function (HP:0007686)2.46959471
63Nephrolithiasis (HP:0000787)2.43831230
64Segmental peripheral demyelination/remyelination (HP:0003481)2.39608950
65Adrenal overactivity (HP:0002717)2.38971615
66Rickets (HP:0002748)2.38806789
67Hypopigmentation of the fundus (HP:0007894)2.38084658
68Hypophosphatemia (HP:0002148)2.36447470
69Abnormality of macular pigmentation (HP:0008002)2.32974551
70Dehydration (HP:0001944)2.32428247
71Abnormality of sodium homeostasis (HP:0010931)2.29819283
72Hyperglycinemia (HP:0002154)2.28068076
73Hypoglycemic seizures (HP:0002173)2.28059088
74Increased corneal curvature (HP:0100692)2.27683763
75Keratoconus (HP:0000563)2.27683763
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26670637
77Symptomatic seizures (HP:0011145)2.26224446
78Hyperinsulinemic hypoglycemia (HP:0000825)2.25871449
79Lymphangioma (HP:0100764)2.22903934
80Hyponatremia (HP:0002902)2.20708271
81Widely patent fontanelles and sutures (HP:0004492)2.14423692
82Chondrocalcinosis (HP:0000934)2.12172807
83Tubular atrophy (HP:0000092)2.11457794
84Abnormality of renal resorption (HP:0011038)2.10831959
85Enlarged kidneys (HP:0000105)2.10329367
86Vascular calcification (HP:0004934)2.09809025
87Termporal pattern (HP:0011008)2.08888627
88Insidious onset (HP:0003587)2.08888627
89Abnormality of Sharpey fibers (HP:0100685)2.03578337
90Renal tubular dysfunction (HP:0000124)2.01523591
91Systemic lupus erythematosus (HP:0002725)1.99607982
92Metaphyseal cupping (HP:0003021)1.99571582
93Hyperammonemia (HP:0001987)1.97828052
94Decreased circulating renin level (HP:0003351)1.97558910
95Bilateral sensorineural hearing impairment (HP:0008619)1.93525162
96Tubulointerstitial fibrosis (HP:0005576)1.91536842
97Dicarboxylic aciduria (HP:0003215)1.88490956
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88490956
99Pancreatic islet-cell hyperplasia (HP:0004510)1.86249973
100Metabolic acidosis (HP:0001942)1.85804811
101Vomiting (HP:0002013)1.85565473
102Vacuolated lymphocytes (HP:0001922)1.83364075
103Cardiovascular calcification (HP:0011915)1.83335551
104Upper limb muscle weakness (HP:0003484)1.82309754
105Paralysis (HP:0003470)1.77397665
106Methylmalonic aciduria (HP:0012120)1.77164131
107Glomerulosclerosis (HP:0000096)1.75102748
108Generalized muscle weakness (HP:0003324)1.74937186
109Dyschromatopsia (HP:0007641)1.73640481
110Bicornuate uterus (HP:0000813)1.70647580
111Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68981611
112Potter facies (HP:0002009)1.68491029
113Facial shape deformation (HP:0011334)1.68491029
114Hypotension (HP:0002615)1.68316177
115Increased CSF protein (HP:0002922)1.66946148
116Abnormal tarsal ossification (HP:0008369)1.66128864
117Abnormal enzyme/coenzyme activity (HP:0012379)1.65779684
118Nausea (HP:0002018)1.64456873
119Abnormal eating behavior (HP:0100738)1.64040910
120Hyperventilation (HP:0002883)1.62320217
121Hyperkalemia (HP:0002153)1.61635262
122Abnormality of the costochondral junction (HP:0000919)1.61468361
123Abnormality of alkaline phosphatase activity (HP:0004379)1.60468216
124Thin bony cortex (HP:0002753)1.59262866
125Hypophosphatemic rickets (HP:0004912)1.59111109
126Type II diabetes mellitus (HP:0005978)1.58565511
127Abnormality of aromatic amino acid family metabolism (HP:0004338)1.58128459
128Malnutrition (HP:0004395)1.57123274
129Complement deficiency (HP:0004431)1.52047513
130Postural tremor (HP:0002174)1.46642017
131Impaired proprioception (HP:0010831)1.41390571
132Impaired platelet aggregation (HP:0003540)1.40395538
133Abnormal platelet function (HP:0011869)1.40395538
134Glomerulonephritis (HP:0000099)1.40195840
135Pigmentary retinal degeneration (HP:0001146)1.40001366
136Progressive sensorineural hearing impairment (HP:0000408)1.37090550
137Neonatal onset (HP:0003623)1.35920296
138Hypoplasia of the iris (HP:0007676)1.35424005
139Cone-rod dystrophy (HP:0000548)1.34344858
140Constricted visual fields (HP:0001133)1.33661734
141Photophobia (HP:0000613)1.27123214
142Chorioretinal atrophy (HP:0000533)1.22371552
143Paresthesia (HP:0003401)1.22297466
144Nephrogenic diabetes insipidus (HP:0009806)1.19385683
145Abnormality of the renal medulla (HP:0100957)1.16722042
146White forelock (HP:0002211)1.14651057
147Abnormality of complement system (HP:0005339)1.12922506
148Abnormality of calcium-phosphate metabolism (HP:0100530)1.12486049
149Esophageal varix (HP:0002040)1.02454629

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE18.65692788
2WNK47.13346626
3OXSR15.98631681
4WNK35.72855820
5STK394.04210475
6KDR2.61227402
7GRK12.30819148
8SGK2231.82129588
9SGK4941.82129588
10INSRR1.80856688
11BCKDK1.80304579
12CAMK1G1.65363247
13WNK11.55507216
14PDK21.48855030
15BMX1.47373032
16CAMK1D1.46698810
17SGK21.19803037
18TEC1.12932916
19TGFBR21.00515860
20STK38L0.98861831
21SGK30.90821048
22PTK2B0.89150492
23TAOK30.84363330
24STK380.83396397
25PDK40.80831096
26PDK30.80831096
27PINK10.78139061
28PRKAA20.75948685
29MAPK150.73685007
30MST40.73094722
31EPHA40.67675632
32EPHA30.65415718
33MAP2K20.64858382
34SGK10.64266112
35TESK20.62249036
36NUAK10.58061058
37GSK3A0.57014564
38ERN10.52180220
39MAPK120.50483273
40IRAK20.50140398
41PNCK0.49678196
42PRKCG0.49472208
43PIK3CG0.49057680
44AKT30.48860813
45PRKCE0.46614432
46PRKAA10.46599188
47ADRBK20.44602167
48PDPK10.42080210
49NEK60.41999593
50NEK10.41531575
51EPHB20.39627743
52LRRK20.39504546
53MST1R0.38908724
54PAK30.38530113
55MYLK0.36542980
56RIPK40.35354997
57PTK20.32914243
58RIPK10.32703091
59MAPK70.31747973
60FGFR30.31328761
61CSNK1A10.31214163
62PRKD20.30373841
63CAMK40.30036202
64MAPK110.29016987
65IRAK30.28861218
66NTRK10.28843245
67NTRK30.28716947
68TNK20.28102549
69OBSCN0.28006252
70MAP2K10.27693856
71DDR20.27238667
72PRKCZ0.26941858
73INSR0.26688957
74ADRBK10.26646880
75TSSK60.26219854
76FER0.25594847
77PRKCI0.25578635
78GRK50.25129544
79EPHB10.24865691
80MINK10.24030359
81PRKG20.23573127
82ABL20.22813912
83DYRK1B0.22607302
84STK110.22428043
85CSK0.22256273
86ITK0.21876002
87FGFR40.21838183
88PRKCH0.21378395
89PRKCA0.20691566
90IRAK10.20382439
91FGR0.20141100
92NTRK20.19981537
93AKT20.19979429
94FRK0.19810719
95FES0.19668560
96PRKCB0.19451170
97PAK40.19422934
98SRC0.19396222
99MAP3K120.19303171
100IGF1R0.19092033
101MET0.18889023
102PRKCD0.18444846
103NLK0.17530373
104TTN0.17523517
105CAMK10.17426341
106PRKACG0.17257056
107CCNB10.16769320
108MAP4K10.15604767
109MAP3K70.15426048
110MAP3K110.15332820
111SCYL20.15297449
112EGFR0.15109592
113PTK60.14582790
114TGFBR10.14445616
115BTK0.14371444
116CDK120.13507008
117ZAP700.13475751
118GRK60.13379850
119CAMKK20.13244594
120CDK50.12754410
121PRKACA0.12247295
122MAP3K30.12115238
123MAP3K10.11515819
124SYK0.11420231
125PRKD10.11163842
126JAK10.10033390
127CSNK1D0.09649241
128PAK60.09529054
129CAMK2B0.09383444
130MAP3K130.09020138
131ROCK10.08998986
132ACVR1B0.08503614
133ICK0.07898887
134PDK10.07874382
135TRPM70.07671006
136MAP3K20.07663048
137PIK3CA0.07580726
138KIT0.06796139
139RET0.06023146
140HIPK20.05935478
141MAPKAPK30.05299307
142CAMK2A0.05199182
143MAPK30.04985988
144TESK10.04605800
145MARK30.03799897
146RPS6KA30.03183341
147STK30.02750571

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.77758395
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.67719650
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.40922783
4Butanoate metabolism_Homo sapiens_hsa006503.23483511
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.15731680
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.87450510
7Propanoate metabolism_Homo sapiens_hsa006402.84065811
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82733613
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.82625314
10Vitamin digestion and absorption_Homo sapiens_hsa049772.68905055
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.43802275
12Collecting duct acid secretion_Homo sapiens_hsa049662.29196935
13Complement and coagulation cascades_Homo sapiens_hsa046102.20403439
14Peroxisome_Homo sapiens_hsa041462.07985132
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02618230
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.99137076
17beta-Alanine metabolism_Homo sapiens_hsa004101.98445745
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96626831
19Fatty acid degradation_Homo sapiens_hsa000711.94508081
20* Bile secretion_Homo sapiens_hsa049761.91883280
21Tryptophan metabolism_Homo sapiens_hsa003801.90727097
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.88334443
23Mineral absorption_Homo sapiens_hsa049781.84072518
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80516101
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75731732
26Pyruvate metabolism_Homo sapiens_hsa006201.69210484
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.65536445
28Arginine and proline metabolism_Homo sapiens_hsa003301.58798692
29PPAR signaling pathway_Homo sapiens_hsa033201.45033191
30Nitrogen metabolism_Homo sapiens_hsa009101.40936728
31Fatty acid metabolism_Homo sapiens_hsa012121.35771371
32Protein digestion and absorption_Homo sapiens_hsa049741.34017021
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31040650
34Gastric acid secretion_Homo sapiens_hsa049711.26630612
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26131928
36Arginine biosynthesis_Homo sapiens_hsa002201.23269403
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18886040
38Glutathione metabolism_Homo sapiens_hsa004801.14337111
39Phenylalanine metabolism_Homo sapiens_hsa003601.12745293
40Sulfur metabolism_Homo sapiens_hsa009201.11759912
41Carbon metabolism_Homo sapiens_hsa012001.09360068
42Staphylococcus aureus infection_Homo sapiens_hsa051501.00683198
43Other glycan degradation_Homo sapiens_hsa005111.00145875
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96843690
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92355432
46Rheumatoid arthritis_Homo sapiens_hsa053230.90676243
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.90493087
48Histidine metabolism_Homo sapiens_hsa003400.89970837
49Lysine degradation_Homo sapiens_hsa003100.89249760
50Fructose and mannose metabolism_Homo sapiens_hsa000510.89178558
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.89169736
52Thyroid hormone synthesis_Homo sapiens_hsa049180.88280803
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84105083
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.82432329
55Linoleic acid metabolism_Homo sapiens_hsa005910.82056124
56Starch and sucrose metabolism_Homo sapiens_hsa005000.81030947
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78611949
58Ether lipid metabolism_Homo sapiens_hsa005650.75474085
59Fat digestion and absorption_Homo sapiens_hsa049750.74753003
60Fatty acid biosynthesis_Homo sapiens_hsa000610.71433357
61Glycerolipid metabolism_Homo sapiens_hsa005610.62888051
62Choline metabolism in cancer_Homo sapiens_hsa052310.60799706
63Vitamin B6 metabolism_Homo sapiens_hsa007500.60577384
64Fatty acid elongation_Homo sapiens_hsa000620.59881191
65Circadian rhythm_Homo sapiens_hsa047100.57279689
66Ovarian steroidogenesis_Homo sapiens_hsa049130.55777643
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55184923
68ABC transporters_Homo sapiens_hsa020100.54153262
69Melanoma_Homo sapiens_hsa052180.53352947
70Synaptic vesicle cycle_Homo sapiens_hsa047210.52809227
71Renin-angiotensin system_Homo sapiens_hsa046140.50520548
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.50472038
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50087350
74Oxidative phosphorylation_Homo sapiens_hsa001900.49898051
75HIF-1 signaling pathway_Homo sapiens_hsa040660.49754724
76Glioma_Homo sapiens_hsa052140.49727558
77Sphingolipid metabolism_Homo sapiens_hsa006000.46167065
78Biosynthesis of amino acids_Homo sapiens_hsa012300.45842400
79GABAergic synapse_Homo sapiens_hsa047270.45255085
80Salivary secretion_Homo sapiens_hsa049700.44999665
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44728422
82Non-small cell lung cancer_Homo sapiens_hsa052230.43227940
83Rap1 signaling pathway_Homo sapiens_hsa040150.42198215
84Folate biosynthesis_Homo sapiens_hsa007900.41824176
85Ras signaling pathway_Homo sapiens_hsa040140.41053476
86Chemical carcinogenesis_Homo sapiens_hsa052040.40864859
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40835513
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.40265111
89Prion diseases_Homo sapiens_hsa050200.39742981
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39652748
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38883357
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.38576708
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38245424
94Insulin secretion_Homo sapiens_hsa049110.35520194
95Adherens junction_Homo sapiens_hsa045200.34050828
96Calcium signaling pathway_Homo sapiens_hsa040200.33950139
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.33698418
98Pancreatic secretion_Homo sapiens_hsa049720.33585031
99Bladder cancer_Homo sapiens_hsa052190.32771363
100Circadian entrainment_Homo sapiens_hsa047130.32549788
101Morphine addiction_Homo sapiens_hsa050320.31264301
102Vibrio cholerae infection_Homo sapiens_hsa051100.31161472
103Lysosome_Homo sapiens_hsa041420.30372259
104Pertussis_Homo sapiens_hsa051330.30221501
105Endometrial cancer_Homo sapiens_hsa052130.30049266
106Renin secretion_Homo sapiens_hsa049240.29758180
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29756591
108Metabolic pathways_Homo sapiens_hsa011000.29374845
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27409941
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.26883848
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.26607002
112Tyrosine metabolism_Homo sapiens_hsa003500.26474377
113Cardiac muscle contraction_Homo sapiens_hsa042600.26083666
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25658584
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24947562
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24838507
117Glutamatergic synapse_Homo sapiens_hsa047240.23060895
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22804501
119Serotonergic synapse_Homo sapiens_hsa047260.21599876
120Retinol metabolism_Homo sapiens_hsa008300.21547952
121FoxO signaling pathway_Homo sapiens_hsa040680.21258477
122Tight junction_Homo sapiens_hsa045300.21233281
123ECM-receptor interaction_Homo sapiens_hsa045120.20582821
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20328296
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19364345
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.19350867
127Pentose phosphate pathway_Homo sapiens_hsa000300.18936711
128Taste transduction_Homo sapiens_hsa047420.18830252
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18822981
130Inositol phosphate metabolism_Homo sapiens_hsa005620.18244012
131Selenocompound metabolism_Homo sapiens_hsa004500.17546385
132Gap junction_Homo sapiens_hsa045400.17428882
133Glucagon signaling pathway_Homo sapiens_hsa049220.16742761
134Arachidonic acid metabolism_Homo sapiens_hsa005900.16356381
135Focal adhesion_Homo sapiens_hsa045100.16152407

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