SLC22A9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glyoxylate metabolic process (GO:0046487)6.22939702
2drug catabolic process (GO:0042737)6.12236021
3regulation of fibrinolysis (GO:0051917)6.01732081
4exogenous drug catabolic process (GO:0042738)5.64677774
5negative regulation of fibrinolysis (GO:0051918)5.58519700
6L-phenylalanine catabolic process (GO:0006559)5.58401941
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.58401941
8regulation of protein activation cascade (GO:2000257)5.17111096
9protein carboxylation (GO:0018214)4.98475405
10peptidyl-glutamic acid carboxylation (GO:0017187)4.98475405
11aromatic amino acid family catabolic process (GO:0009074)4.94698229
12serine family amino acid catabolic process (GO:0009071)4.89698526
13regulation of complement activation (GO:0030449)4.80993267
14epoxygenase P450 pathway (GO:0019373)4.78636768
15complement activation, alternative pathway (GO:0006957)4.78009435
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.76688628
17regulation of triglyceride catabolic process (GO:0010896)4.75520038
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.73654128
19L-phenylalanine metabolic process (GO:0006558)4.73654128
20negative regulation of cholesterol transport (GO:0032375)4.72708964
21negative regulation of sterol transport (GO:0032372)4.72708964
22high-density lipoprotein particle remodeling (GO:0034375)4.48388784
23cellular ketone body metabolic process (GO:0046950)4.46379441
24oxidative demethylation (GO:0070989)4.46217897
25blood coagulation, intrinsic pathway (GO:0007597)4.45044184
26indole-containing compound catabolic process (GO:0042436)4.38072707
27indolalkylamine catabolic process (GO:0046218)4.38072707
28tryptophan catabolic process (GO:0006569)4.38072707
29protein-lipid complex remodeling (GO:0034368)4.37782798
30macromolecular complex remodeling (GO:0034367)4.37782798
31plasma lipoprotein particle remodeling (GO:0034369)4.37782798
32phenylpropanoid metabolic process (GO:0009698)4.35174899
33regulation of cholesterol esterification (GO:0010872)4.31389378
34omega-hydroxylase P450 pathway (GO:0097267)4.26023964
35triglyceride homeostasis (GO:0070328)4.20226597
36acylglycerol homeostasis (GO:0055090)4.20226597
37fibrinolysis (GO:0042730)4.12273709
38reverse cholesterol transport (GO:0043691)4.08796776
39ketone body metabolic process (GO:1902224)3.98566784
40bile acid biosynthetic process (GO:0006699)3.97056805
41cellular glucuronidation (GO:0052695)3.93568812
42phospholipid efflux (GO:0033700)3.90305175
43drug metabolic process (GO:0017144)3.87500848
44glycine metabolic process (GO:0006544)3.77816196
45tryptophan metabolic process (GO:0006568)3.77791403
46glucuronate metabolic process (GO:0019585)3.76548958
47uronic acid metabolic process (GO:0006063)3.76548958
48regulation of plasminogen activation (GO:0010755)3.73190985
49cholesterol efflux (GO:0033344)3.68788669
50plasma lipoprotein particle clearance (GO:0034381)3.65415630
51peptidyl-glutamic acid modification (GO:0018200)3.64319264
52indolalkylamine metabolic process (GO:0006586)3.63995789
53low-density lipoprotein particle remodeling (GO:0034374)3.61850146
54bile acid metabolic process (GO:0008206)3.58228928
55pyrimidine nucleobase catabolic process (GO:0006208)3.56989470
56aromatic amino acid family metabolic process (GO:0009072)3.56839110
57arginine metabolic process (GO:0006525)3.56229062
58S-adenosylmethionine metabolic process (GO:0046500)3.53914110
59intestinal cholesterol absorption (GO:0030299)3.50769465
60negative regulation of lipase activity (GO:0060192)3.46333473
61regulation of lipoprotein particle clearance (GO:0010984)3.42966471
62negative regulation of protein activation cascade (GO:2000258)3.40857098
63very-low-density lipoprotein particle assembly (GO:0034379)3.39713665
64alpha-amino acid catabolic process (GO:1901606)3.37213287
65bile acid and bile salt transport (GO:0015721)3.37201118
66negative regulation of hemostasis (GO:1900047)3.35572396
67negative regulation of blood coagulation (GO:0030195)3.35572396
68alkaloid metabolic process (GO:0009820)3.34793054
69kynurenine metabolic process (GO:0070189)3.33600298
70serine family amino acid metabolic process (GO:0009069)3.31145206
71flavonoid metabolic process (GO:0009812)3.27124837
72cellular biogenic amine catabolic process (GO:0042402)3.24714365
73amine catabolic process (GO:0009310)3.24714365
74amino-acid betaine metabolic process (GO:0006577)3.23330394
75plasma lipoprotein particle organization (GO:0071827)3.22917666
76nucleobase catabolic process (GO:0046113)3.19808650
77protein activation cascade (GO:0072376)3.19775240
78arginine catabolic process (GO:0006527)3.16993277
79imidazole-containing compound metabolic process (GO:0052803)3.13410364
80tyrosine metabolic process (GO:0006570)3.08147110
81negative regulation of coagulation (GO:0050819)3.06372393
82detection of light stimulus involved in sensory perception (GO:0050962)3.05317509
83detection of light stimulus involved in visual perception (GO:0050908)3.05317509
84response to misfolded protein (GO:0051788)3.04738589
85drug transmembrane transport (GO:0006855)3.02609682
86ethanol oxidation (GO:0006069)3.02538932
87cysteine metabolic process (GO:0006534)3.02031091
88behavioral response to nicotine (GO:0035095)3.00981585
89heme transport (GO:0015886)3.00953882
90cellular amino acid catabolic process (GO:0009063)2.97788412
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.96726734
92negative regulation of wound healing (GO:0061045)2.95413250
93regulation of bile acid biosynthetic process (GO:0070857)2.93724988
94cytolysis (GO:0019835)2.93348362
95plasma lipoprotein particle assembly (GO:0034377)2.93269626
96alanine transport (GO:0032328)2.90787625
97negative regulation of complement activation (GO:0045916)2.90755002
98water-soluble vitamin biosynthetic process (GO:0042364)2.90694500
99gamma-aminobutyric acid transport (GO:0015812)2.87387967
100positive regulation of lipoprotein lipase activity (GO:0051006)2.85070866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse3.58872145
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.49217472
3ZNF274_21170338_ChIP-Seq_K562_Hela3.09631988
4EZH2_22144423_ChIP-Seq_EOC_Human2.90029194
5VDR_22108803_ChIP-Seq_LS180_Human2.72389432
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71689580
7GBX2_23144817_ChIP-Seq_PC3_Human2.59244985
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29946942
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.23131953
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22451679
11IGF1R_20145208_ChIP-Seq_DFB_Human2.17465707
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.02598276
13LXR_22158963_ChIP-Seq_LIVER_Mouse1.97510583
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92355141
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91461191
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90513725
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89288234
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86829129
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.85022823
20BCAT_22108803_ChIP-Seq_LS180_Human1.79129943
21ER_23166858_ChIP-Seq_MCF-7_Human1.76613458
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71895724
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.70269681
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64743711
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59594826
26REST_21632747_ChIP-Seq_MESCs_Mouse1.56356778
27P300_19829295_ChIP-Seq_ESCs_Human1.55427605
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49975684
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.48892333
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47068496
31ETV2_25802403_ChIP-Seq_MESCs_Mouse1.46287044
32CBP_20019798_ChIP-Seq_JUKART_Human1.44628086
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44628086
34TAF15_26573619_Chip-Seq_HEK293_Human1.44110439
35IRF1_19129219_ChIP-ChIP_H3396_Human1.43828131
36* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42443913
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40635713
38HTT_18923047_ChIP-ChIP_STHdh_Human1.37626178
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.35653819
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.35340477
41STAT3_23295773_ChIP-Seq_U87_Human1.34809223
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34402590
43PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.33882414
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33617082
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33558998
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32634987
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32332740
48* GATA3_21878914_ChIP-Seq_MCF-7_Human1.31743063
49DROSHA_22980978_ChIP-Seq_HELA_Human1.31530926
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29163404
51* TCF4_23295773_ChIP-Seq_U87_Human1.28841211
52NANOG_19829295_ChIP-Seq_ESCs_Human1.28619057
53SOX2_19829295_ChIP-Seq_ESCs_Human1.28619057
54AR_25329375_ChIP-Seq_VCAP_Human1.28260883
55TCF4_22108803_ChIP-Seq_LS180_Human1.28199121
56NCOR_22424771_ChIP-Seq_293T_Human1.27289101
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.26869012
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26869012
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.26213087
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25267517
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23149348
62TP53_22573176_ChIP-Seq_HFKS_Human1.20735820
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19827814
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19659747
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19061652
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19061652
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.18760227
68AR_20517297_ChIP-Seq_VCAP_Human1.17995157
69* SMAD4_21799915_ChIP-Seq_A2780_Human1.17567495
70MYC_19829295_ChIP-Seq_ESCs_Human1.16720525
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16668692
72* HNF4A_19822575_ChIP-Seq_HepG2_Human1.16668243
73ERA_21632823_ChIP-Seq_H3396_Human1.15931856
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14347796
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13533252
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.12949207
77FUS_26573619_Chip-Seq_HEK293_Human1.12801067
78FOXH1_21741376_ChIP-Seq_EPCs_Human1.11938081
79AR_21572438_ChIP-Seq_LNCaP_Human1.11561079
80TAF2_19829295_ChIP-Seq_ESCs_Human1.10970540
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10262621
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.09656739
83OCT4_20526341_ChIP-Seq_ESCs_Human1.07066330
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05427356
85RNF2_27304074_Chip-Seq_NSC_Mouse1.04767700
86RUNX2_22187159_ChIP-Seq_PCA_Human1.04644648
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.04189048
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02997008
89* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02552963
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.02278763
91* FOXA2_19822575_ChIP-Seq_HepG2_Human1.02011097
92AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02007464
93TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99516230
94EZH2_27294783_Chip-Seq_ESCs_Mouse0.99320930
95EWS_26573619_Chip-Seq_HEK293_Human0.98844367
96* NANOG_20526341_ChIP-Seq_ESCs_Human0.97828861
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97726178
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97311775
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96751496
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96485473

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.40449143
2MP0003195_calcinosis5.33432667
3MP0005360_urolithiasis4.44070272
4MP0005085_abnormal_gallbladder_physiolo3.97827020
5MP0005365_abnormal_bile_salt3.91601272
6MP0002138_abnormal_hepatobiliary_system3.71253856
7MP0008875_abnormal_xenobiotic_pharmacok3.70372432
8MP0002876_abnormal_thyroid_physiology2.79931768
9MP0003252_abnormal_bile_duct2.66968504
10MP0010329_abnormal_lipoprotein_level2.58704881
11MP0009697_abnormal_copulation2.07792774
12MP0005551_abnormal_eye_electrophysiolog2.02178572
13MP0001666_abnormal_nutrient_absorption1.98903117
14MP0003122_maternal_imprinting1.97667280
15MP0005332_abnormal_amino_acid1.95452274
16MP0003011_delayed_dark_adaptation1.89600821
17MP0000566_synostosis1.73627288
18MP0003868_abnormal_feces_composition1.72744029
19MP0005645_abnormal_hypothalamus_physiol1.69045361
20MP0001764_abnormal_homeostasis1.62621997
21MP0002102_abnormal_ear_morphology1.55799547
22MP0008872_abnormal_physiological_respon1.50683924
23MP0003878_abnormal_ear_physiology1.46646009
24MP0005377_hearing/vestibular/ear_phenot1.46646009
25MP0005379_endocrine/exocrine_gland_phen1.41761028
26MP0005646_abnormal_pituitary_gland1.41585419
27MP0009745_abnormal_behavioral_response1.40837782
28MP0006292_abnormal_olfactory_placode1.36840859
29MP0003880_abnormal_central_pattern1.34302518
30MP0001986_abnormal_taste_sensitivity1.33033184
31MP0004142_abnormal_muscle_tone1.29145876
32MP0004019_abnormal_vitamin_homeostasis1.24962887
33MP0005084_abnormal_gallbladder_morpholo1.24850967
34MP0009046_muscle_twitch1.24400197
35MP0002938_white_spotting1.22342609
36MP0006276_abnormal_autonomic_nervous1.21612332
37MP0001984_abnormal_olfaction1.20900412
38MP0002118_abnormal_lipid_homeostasis1.20797254
39MP0001485_abnormal_pinna_reflex1.19773023
40MP0004885_abnormal_endolymph1.18073963
41MP0001486_abnormal_startle_reflex1.14855054
42MP0005253_abnormal_eye_physiology1.14170905
43MP0005410_abnormal_fertilization1.13754992
44MP0002837_dystrophic_cardiac_calcinosis1.13527023
45MP0004742_abnormal_vestibular_system1.11645712
46MP0003646_muscle_fatigue1.11454094
47MP0004043_abnormal_pH_regulation1.10045409
48MP0001501_abnormal_sleep_pattern1.09748624
49MP0002638_abnormal_pupillary_reflex1.09025853
50MP0006072_abnormal_retinal_apoptosis1.07641001
51MP0002557_abnormal_social/conspecific_i1.07444639
52MP0003806_abnormal_nucleotide_metabolis1.06756908
53MP0001968_abnormal_touch/_nociception1.06441974
54MP0002928_abnormal_bile_duct1.04758261
55MP0002064_seizures1.03806011
56MP0002272_abnormal_nervous_system1.03647506
57MP0004133_heterotaxia0.98704201
58MP0001529_abnormal_vocalization0.98355440
59MP0003879_abnormal_hair_cell0.97957504
60MP0005636_abnormal_mineral_homeostasis0.97202034
61MP0003787_abnormal_imprinting0.95746608
62MP0005408_hypopigmentation0.94739829
63MP0000609_abnormal_liver_physiology0.94298230
64MP0008877_abnormal_DNA_methylation0.93922257
65MP0002735_abnormal_chemical_nociception0.92099397
66MP0002909_abnormal_adrenal_gland0.91686365
67MP0000372_irregular_coat_pigmentation0.89178549
68MP0003121_genomic_imprinting0.87248432
69MP0002572_abnormal_emotion/affect_behav0.85816392
70MP0009840_abnormal_foam_cell0.85031473
71MP0005167_abnormal_blood-brain_barrier0.83489280
72MP0003136_yellow_coat_color0.82728636
73MP0001440_abnormal_grooming_behavior0.82528569
74MP0005195_abnormal_posterior_eye0.81059380
75MP0003186_abnormal_redox_activity0.80737510
76MP0010386_abnormal_urinary_bladder0.80674144
77MP0005448_abnormal_energy_balance0.79289900
78MP0001324_abnormal_eye_pigmentation0.77951133
79MP0001905_abnormal_dopamine_level0.77855572
80MP0002163_abnormal_gland_morphology0.77749581
81MP0003718_maternal_effect0.77398073
82MP0002078_abnormal_glucose_homeostasis0.76658791
83MP0001963_abnormal_hearing_physiology0.74771380
84MP0002733_abnormal_thermal_nociception0.72643721
85MP0002822_catalepsy0.72430210
86MP0000026_abnormal_inner_ear0.72228737
87MP0002736_abnormal_nociception_after0.70675211
88MP0005187_abnormal_penis_morphology0.70104657
89MP0002067_abnormal_sensory_capabilities0.69642286
90MP0009643_abnormal_urine_homeostasis0.68818589
91MP0001944_abnormal_pancreas_morphology0.68748974
92MP0009642_abnormal_blood_homeostasis0.68558777
93MP0005395_other_phenotype0.68185688
94MP0003953_abnormal_hormone_level0.68088205
95MP0005319_abnormal_enzyme/_coenzyme0.68054383
96MP0005386_behavior/neurological_phenoty0.67810580
97MP0004924_abnormal_behavior0.67810580
98MP0000639_abnormal_adrenal_gland0.67753464
99MP0003698_abnormal_male_reproductive0.63640028
100MP0002160_abnormal_reproductive_system0.63381440

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.41458831
2Prolonged partial thromboplastin time (HP:0003645)6.36961227
3Hypobetalipoproteinemia (HP:0003563)5.50509873
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.54132965
5Complement deficiency (HP:0004431)4.30772485
6Joint hemorrhage (HP:0005261)4.28349601
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.27334763
8Xanthomatosis (HP:0000991)3.62562820
9Congenital stationary night blindness (HP:0007642)3.49570653
10Hyperglycinemia (HP:0002154)3.32284016
11Hyperlipoproteinemia (HP:0010980)3.16735511
12Spontaneous abortion (HP:0005268)3.02179544
13Pancreatic cysts (HP:0001737)3.00333599
14Hypolipoproteinemia (HP:0010981)2.84743875
15Conjugated hyperbilirubinemia (HP:0002908)2.82669276
16Abnormality of pyrimidine metabolism (HP:0004353)2.81006840
17Pendular nystagmus (HP:0012043)2.80484931
18Decreased central vision (HP:0007663)2.80204746
19True hermaphroditism (HP:0010459)2.78070876
20Abnormality of complement system (HP:0005339)2.77416804
21Chronic hepatic failure (HP:0100626)2.75362527
22Intrahepatic cholestasis (HP:0001406)2.72107470
23Generalized aminoaciduria (HP:0002909)2.68203110
24Molar tooth sign on MRI (HP:0002419)2.66697412
25Abnormality of midbrain morphology (HP:0002418)2.66697412
26Systemic lupus erythematosus (HP:0002725)2.64504756
27Glomerulonephritis (HP:0000099)2.64430616
28Pancreatic fibrosis (HP:0100732)2.61435561
29Severe visual impairment (HP:0001141)2.59782981
30Abolished electroretinogram (ERG) (HP:0000550)2.54588457
31Hypothermia (HP:0002045)2.51222828
32Abnormal rod and cone electroretinograms (HP:0008323)2.50985148
33Abnormality of glycine metabolism (HP:0010895)2.50825599
34Abnormality of serine family amino acid metabolism (HP:0010894)2.50825599
35Abnormality of the common coagulation pathway (HP:0010990)2.50569552
36Nephronophthisis (HP:0000090)2.49271869
37Ketosis (HP:0001946)2.43905110
38Abnormal biliary tract physiology (HP:0012439)2.43799128
39Bile duct proliferation (HP:0001408)2.43799128
40Abnormality of the renal cortex (HP:0011035)2.43173507
41Hyperglycinuria (HP:0003108)2.40911604
42Glycosuria (HP:0003076)2.40713638
43Abnormality of urine glucose concentration (HP:0011016)2.40713638
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.39751286
45Acute encephalopathy (HP:0006846)2.39448361
46Attenuation of retinal blood vessels (HP:0007843)2.38286525
47Arthropathy (HP:0003040)2.36548733
48Epidermoid cyst (HP:0200040)2.33201289
49Fair hair (HP:0002286)2.31920321
50Progressive cerebellar ataxia (HP:0002073)2.30118117
51Type II lissencephaly (HP:0007260)2.29825849
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.25139199
53Enlarged kidneys (HP:0000105)2.21676900
54Acute necrotizing encephalopathy (HP:0006965)2.20875297
55Hyperventilation (HP:0002883)2.19287825
56Hypophosphatemic rickets (HP:0004912)2.16858784
57Potter facies (HP:0002009)2.15784403
58Facial shape deformation (HP:0011334)2.15784403
59Renal cortical cysts (HP:0000803)2.14396053
60Abnormality of serum amino acid levels (HP:0003112)2.14245741
61Vascular calcification (HP:0004934)2.12225211
62Cystic liver disease (HP:0006706)2.12198440
63Abnormality of the renal medulla (HP:0100957)2.10997794
64Delayed CNS myelination (HP:0002188)2.10509938
65Genetic anticipation (HP:0003743)2.08551928
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03862811
67Abnormality of alanine metabolism (HP:0010916)2.03862811
68Hyperalaninemia (HP:0003348)2.03862811
69Mitochondrial inheritance (HP:0001427)2.00448158
70Increased corneal curvature (HP:0100692)2.00257156
71Keratoconus (HP:0000563)2.00257156
72Metabolic acidosis (HP:0001942)1.97618210
73Increased CSF lactate (HP:0002490)1.96444094
74Cerebral edema (HP:0002181)1.95997860
75Lethargy (HP:0001254)1.93317701
76Hepatic necrosis (HP:0002605)1.92784074
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90086737
78Abnormal mitochondria in muscle tissue (HP:0008316)1.87476624
79Methylmalonic acidemia (HP:0002912)1.86845536
80Abnormality of the vitreous humor (HP:0004327)1.86620959
81Fat malabsorption (HP:0002630)1.85741657
82Large for gestational age (HP:0001520)1.85730731
83Ketoacidosis (HP:0001993)1.84813904
84Methylmalonic aciduria (HP:0012120)1.83335493
85Abnormal urine output (HP:0012590)1.83333019
86Osteomalacia (HP:0002749)1.81516753
87Sclerocornea (HP:0000647)1.81368128
88Gaze-evoked nystagmus (HP:0000640)1.80919949
89Retinal dysplasia (HP:0007973)1.80890880
90Retinal atrophy (HP:0001105)1.77687787
91Progressive macrocephaly (HP:0004481)1.77590598
92Hepatocellular necrosis (HP:0001404)1.77503395
93Reduced antithrombin III activity (HP:0001976)1.75413891
94Hyperphosphaturia (HP:0003109)1.75356816
95Late onset (HP:0003584)1.71875336
96Pigmentary retinal degeneration (HP:0001146)1.69268553
97Male pseudohermaphroditism (HP:0000037)1.68842252
98Nephritis (HP:0000123)1.68187040
99Abnormal drinking behavior (HP:0030082)1.67225899
100Polydipsia (HP:0001959)1.67225899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.14688289
2MAP4K23.51426568
3ADRBK23.31015216
4WNK43.20869472
5GRK12.86222581
6WNK32.67712430
7BMPR1B2.67358023
8INSRR2.57656837
9TAOK32.18036823
10TLK12.16656637
11BCKDK2.11775475
12PINK12.03102024
13ZAK1.80718461
14CASK1.76953838
15NUAK11.67773503
16OXSR11.60910570
17PRKCG1.58512169
18SIK21.58271793
19MAPK131.54278747
20TXK1.54230759
21STK391.51163203
22DAPK21.47998306
23DYRK21.46163594
24MAP3K41.41865769
25STK38L1.38748313
26STK161.30538523
27FGFR21.25194848
28PAK31.25060330
29BRSK21.19932231
30MAP2K71.16365884
31CAMKK21.13681255
32MAP2K61.10826552
33NTRK31.10711723
34PRKCE1.09506207
35PIK3CA1.05858791
36ACVR1B1.03646700
37ADRBK10.98175445
38PLK20.94541084
39MARK10.93624025
40PIK3CG0.85935957
41NTRK20.83110593
42PLK40.81775300
43CSNK1G10.76190083
44FGFR40.76033452
45VRK10.73490017
46AKT30.71995085
47ERBB20.71686920
48PRKACA0.71298885
49TNK20.68259277
50PRKAA20.68170268
51CSNK1D0.66698678
52CSNK1G30.64902702
53PRKAA10.64547056
54PRKCQ0.63927380
55PRKCZ0.63110173
56CSNK1G20.61922219
57PTK2B0.61908305
58WNK10.61619738
59ITK0.61540491
60CSNK1A10.61434575
61PKN10.60061538
62FGFR30.59832473
63PRKACG0.58987960
64CSNK1A1L0.58612093
65TIE10.57535533
66CDK80.56278633
67MAP2K40.55362451
68MUSK0.54911487
69EPHA40.53123088
70PRKCA0.52921777
71MAPK150.52168788
72TNIK0.51155932
73CCNB10.49767428
74VRK20.48652483
75STK110.48236117
76PRKG10.47937653
77CAMK10.47193652
78TYRO30.47102196
79MKNK20.44288327
80MAP3K120.44113433
81PRKCI0.43596996
82CAMK2A0.42726648
83DYRK1B0.42428899
84PHKG20.42305343
85PHKG10.42305343
86SGK4940.40968957
87SGK2230.40968957
88MAPK110.40328402
89MST40.39298039
90TEC0.39151504
91CAMK40.38751181
92RPS6KA50.37887212
93CSNK1E0.36160033
94SGK10.36033449
95CAMK1D0.34767755
96BCR0.34580987
97PRKACB0.33758458
98BRSK10.33142366
99SGK20.32640517
100PRKCB0.32032638

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046103.38653393
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.33065579
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.13048696
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.91070854
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.89548832
6Retinol metabolism_Homo sapiens_hsa008302.81522063
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.68727346
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.66497189
9Butanoate metabolism_Homo sapiens_hsa006502.55229735
10Chemical carcinogenesis_Homo sapiens_hsa052042.54244273
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.54020294
12Caffeine metabolism_Homo sapiens_hsa002322.51215253
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.32203156
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21708627
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21465197
16Linoleic acid metabolism_Homo sapiens_hsa005912.12066100
17Tryptophan metabolism_Homo sapiens_hsa003801.95394110
18Fatty acid degradation_Homo sapiens_hsa000711.92672267
19Arginine biosynthesis_Homo sapiens_hsa002201.88959359
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86723506
21Peroxisome_Homo sapiens_hsa041461.76736447
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76646176
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75538800
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.75375365
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68906467
26Histidine metabolism_Homo sapiens_hsa003401.65293608
27Phenylalanine metabolism_Homo sapiens_hsa003601.63518080
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.54412646
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47389415
30Bile secretion_Homo sapiens_hsa049761.45123948
31Fat digestion and absorption_Homo sapiens_hsa049751.41181409
32Tyrosine metabolism_Homo sapiens_hsa003501.38978438
33beta-Alanine metabolism_Homo sapiens_hsa004101.34171517
34Propanoate metabolism_Homo sapiens_hsa006401.26167587
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23970927
36PPAR signaling pathway_Homo sapiens_hsa033201.17552642
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13769613
38Arachidonic acid metabolism_Homo sapiens_hsa005901.13024770
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12659725
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11762666
41ABC transporters_Homo sapiens_hsa020101.09342244
42Starch and sucrose metabolism_Homo sapiens_hsa005001.08753994
43Phototransduction_Homo sapiens_hsa047441.07655834
44Selenocompound metabolism_Homo sapiens_hsa004501.05386524
45Oxidative phosphorylation_Homo sapiens_hsa001900.99880645
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.99274863
47Sulfur metabolism_Homo sapiens_hsa009200.96690913
48Nitrogen metabolism_Homo sapiens_hsa009100.96201557
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.95143106
50Steroid biosynthesis_Homo sapiens_hsa001000.93360086
51Protein export_Homo sapiens_hsa030600.91891409
52Arginine and proline metabolism_Homo sapiens_hsa003300.91485902
53Fatty acid metabolism_Homo sapiens_hsa012120.90648998
54Nicotine addiction_Homo sapiens_hsa050330.88365958
55One carbon pool by folate_Homo sapiens_hsa006700.87915057
56Staphylococcus aureus infection_Homo sapiens_hsa051500.85261450
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81882208
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78700848
59Ether lipid metabolism_Homo sapiens_hsa005650.77960888
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74510774
61Pyruvate metabolism_Homo sapiens_hsa006200.68424735
62Metabolic pathways_Homo sapiens_hsa011000.68251983
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67615399
64Parkinsons disease_Homo sapiens_hsa050120.64486919
65Sulfur relay system_Homo sapiens_hsa041220.62853887
66Vitamin digestion and absorption_Homo sapiens_hsa049770.58700324
67Vitamin B6 metabolism_Homo sapiens_hsa007500.57096879
68Glycerolipid metabolism_Homo sapiens_hsa005610.54159600
69GABAergic synapse_Homo sapiens_hsa047270.52979269
70Serotonergic synapse_Homo sapiens_hsa047260.46963046
71RNA polymerase_Homo sapiens_hsa030200.45882619
72Lysine degradation_Homo sapiens_hsa003100.45771883
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45293982
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43810745
75Taste transduction_Homo sapiens_hsa047420.43344088
76Fatty acid biosynthesis_Homo sapiens_hsa000610.38485906
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37770247
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37088796
79Alzheimers disease_Homo sapiens_hsa050100.36150371
80Glutathione metabolism_Homo sapiens_hsa004800.36100853
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36004417
82Insulin secretion_Homo sapiens_hsa049110.35064213
83Fatty acid elongation_Homo sapiens_hsa000620.32513461
84Morphine addiction_Homo sapiens_hsa050320.32358912
85Huntingtons disease_Homo sapiens_hsa050160.31390672
86Olfactory transduction_Homo sapiens_hsa047400.28615385
87Cardiac muscle contraction_Homo sapiens_hsa042600.27258484
88Glutamatergic synapse_Homo sapiens_hsa047240.25786267
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23878439
90Mineral absorption_Homo sapiens_hsa049780.23206981
91Biosynthesis of amino acids_Homo sapiens_hsa012300.22834416
92Regulation of autophagy_Homo sapiens_hsa041400.22816425
93Ovarian steroidogenesis_Homo sapiens_hsa049130.21435812
94Homologous recombination_Homo sapiens_hsa034400.19831791
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18969305
96Basal transcription factors_Homo sapiens_hsa030220.18359866
97Carbon metabolism_Homo sapiens_hsa012000.15454159
98Fanconi anemia pathway_Homo sapiens_hsa034600.13543125
99Cocaine addiction_Homo sapiens_hsa050300.11375565
100Circadian rhythm_Homo sapiens_hsa047100.11167902

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