SLC23A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.43088579
2epoxygenase P450 pathway (GO:0019373)8.06400816
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.64849462
4L-phenylalanine catabolic process (GO:0006559)7.35450971
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.35450971
6aromatic amino acid family catabolic process (GO:0009074)7.14820708
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.08448427
8L-phenylalanine metabolic process (GO:0006558)7.08448427
9indole-containing compound catabolic process (GO:0042436)6.91258894
10indolalkylamine catabolic process (GO:0046218)6.91258894
11tryptophan catabolic process (GO:0006569)6.91258894
12NADH metabolic process (GO:0006734)6.53607858
13tryptophan metabolic process (GO:0006568)6.49347251
14kynurenine metabolic process (GO:0070189)6.45427146
15fat-soluble vitamin biosynthetic process (GO:0042362)6.36979505
16glyoxylate metabolic process (GO:0046487)6.26688892
17cysteine metabolic process (GO:0006534)6.16351914
18lipoprotein transport (GO:0042953)6.15948218
19lysine metabolic process (GO:0006553)6.12814891
20lysine catabolic process (GO:0006554)6.12814891
21regulation of guanylate cyclase activity (GO:0031282)5.99073162
22intestinal absorption (GO:0050892)5.96230138
23fructose metabolic process (GO:0006000)5.74585048
24hormone catabolic process (GO:0042447)5.60608834
25very-low-density lipoprotein particle assembly (GO:0034379)5.56762520
26bile acid biosynthetic process (GO:0006699)5.51914493
27serine family amino acid catabolic process (GO:0009071)5.43034845
28urate metabolic process (GO:0046415)5.41582428
29drug transmembrane transport (GO:0006855)5.37092383
30homocysteine metabolic process (GO:0050667)5.21874412
31aromatic amino acid family metabolic process (GO:0009072)5.21498337
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.20181323
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.19610960
34sulfur amino acid catabolic process (GO:0000098)5.13175576
35plasma lipoprotein particle assembly (GO:0034377)5.11675994
36amino-acid betaine metabolic process (GO:0006577)5.06903365
37alpha-linolenic acid metabolic process (GO:0036109)4.97006093
38urea metabolic process (GO:0019627)4.94545516
39urea cycle (GO:0000050)4.94545516
40indolalkylamine metabolic process (GO:0006586)4.93149613
41cellular biogenic amine catabolic process (GO:0042402)4.85819971
42amine catabolic process (GO:0009310)4.85819971
43alpha-amino acid catabolic process (GO:1901606)4.78391313
44bile acid metabolic process (GO:0008206)4.73020058
45cellular ketone body metabolic process (GO:0046950)4.68078908
46drug catabolic process (GO:0042737)4.66818251
47diacylglycerol metabolic process (GO:0046339)4.65313275
48nitrogen cycle metabolic process (GO:0071941)4.60042778
49serine family amino acid metabolic process (GO:0009069)4.58978925
50regulation of systemic arterial blood pressure by hormone (GO:0001990)4.58846510
51regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.58846510
52endocrine process (GO:0050886)4.58846510
53drug transport (GO:0015893)4.58675163
54high-density lipoprotein particle remodeling (GO:0034375)4.57700500
55protein-lipid complex assembly (GO:0065005)4.56299373
56glutamate metabolic process (GO:0006536)4.56058713
57tyrosine metabolic process (GO:0006570)4.55948589
58peptidyl-glutamic acid carboxylation (GO:0017187)4.55119703
59protein carboxylation (GO:0018214)4.55119703
60benzene-containing compound metabolic process (GO:0042537)4.50681013
61cellular amino acid catabolic process (GO:0009063)4.47010445
62cellular modified amino acid catabolic process (GO:0042219)4.43464778
63negative regulation of fibrinolysis (GO:0051918)4.42874102
64short-chain fatty acid metabolic process (GO:0046459)4.42548551
65complement activation, alternative pathway (GO:0006957)4.42167034
66positive regulation of guanylate cyclase activity (GO:0031284)4.40928886
67regulation of protein activation cascade (GO:2000257)4.36731764
68regulation of fibrinolysis (GO:0051917)4.34185250
69alkaloid metabolic process (GO:0009820)4.30552489
70aspartate family amino acid catabolic process (GO:0009068)4.26736045
71serine family amino acid biosynthetic process (GO:0009070)4.23031949
72positive regulation of triglyceride lipase activity (GO:0061365)4.21226031
73positive regulation of lipoprotein lipase activity (GO:0051006)4.21226031
74cellular glucuronidation (GO:0052695)4.18735994
75negative regulation of sterol transport (GO:0032372)4.16477576
76negative regulation of cholesterol transport (GO:0032375)4.16477576
77omega-hydroxylase P450 pathway (GO:0097267)4.13015218
78glycine metabolic process (GO:0006544)4.12816219
79regulation of cholesterol esterification (GO:0010872)4.11551455
802-oxoglutarate metabolic process (GO:0006103)4.10705934
81acetyl-CoA metabolic process (GO:0006084)4.09647289
82ethanol metabolic process (GO:0006067)4.09198937
83regulation of complement activation (GO:0030449)4.07262901
84acylglycerol homeostasis (GO:0055090)4.04456896
85triglyceride homeostasis (GO:0070328)4.04456896
86ketone body metabolic process (GO:1902224)4.03555036
87bile acid and bile salt transport (GO:0015721)4.03544447
88regulation of systemic arterial blood pressure (GO:0003073)4.03129459
89regulation of triglyceride catabolic process (GO:0010896)4.02584980
90lipoprotein metabolic process (GO:0042157)4.01384827
91coenzyme catabolic process (GO:0009109)4.01103355
92aldehyde catabolic process (GO:0046185)4.00791270
93reverse cholesterol transport (GO:0043691)3.99603048
94ethanol oxidation (GO:0006069)3.98809846
95exogenous drug catabolic process (GO:0042738)3.96516141
96carboxylic acid catabolic process (GO:0046395)3.95686413
97organic acid catabolic process (GO:0016054)3.95686413
98carnitine metabolic process (GO:0009437)3.92911243
99protein-lipid complex remodeling (GO:0034368)3.91746746
100macromolecular complex remodeling (GO:0034367)3.91746746
101plasma lipoprotein particle remodeling (GO:0034369)3.91746746
102dicarboxylic acid biosynthetic process (GO:0043650)3.89055172
103valine metabolic process (GO:0006573)3.88966832
104glucuronate metabolic process (GO:0019585)3.86825967
105uronic acid metabolic process (GO:0006063)3.86825967
106phospholipid efflux (GO:0033700)3.84268151
107imidazole-containing compound metabolic process (GO:0052803)3.82306757
108peptide catabolic process (GO:0043171)3.81359580
109fatty acid oxidation (GO:0019395)3.80027340
110fatty acid beta-oxidation (GO:0006635)3.79331913
111plasma lipoprotein particle organization (GO:0071827)3.79213255
112renal system process involved in regulation of blood volume (GO:0001977)3.79025481
113receptor guanylyl cyclase signaling pathway (GO:0007168)3.76017573
114proline metabolic process (GO:0006560)3.74106634
115lipid oxidation (GO:0034440)3.72771778
116response to mercury ion (GO:0046689)3.72746530
117glutamine family amino acid biosynthetic process (GO:0009084)3.72109574
118cholesterol efflux (GO:0033344)3.70982644
119peptide hormone processing (GO:0016486)3.70660524
120regulation of bile acid biosynthetic process (GO:0070857)3.67924735
121response to nitrosative stress (GO:0051409)3.66592477
122primary alcohol catabolic process (GO:0034310)3.66166237
123monocarboxylic acid catabolic process (GO:0072329)3.64276159
124virion attachment to host cell (GO:0019062)3.62355932
125adhesion of symbiont to host cell (GO:0044650)3.62355932
126regulation of cGMP biosynthetic process (GO:0030826)3.61902543
127positive regulation of lipid catabolic process (GO:0050996)3.61854157
128arginine metabolic process (GO:0006525)3.61815228
129indole-containing compound metabolic process (GO:0042430)3.59501797
130NAD biosynthetic process (GO:0009435)3.59349437
131flavonoid metabolic process (GO:0009812)3.58430905
132drinking behavior (GO:0042756)3.58378741
133organic cation transport (GO:0015695)3.57182497
134protein-lipid complex subunit organization (GO:0071825)3.57035871
135branched-chain amino acid metabolic process (GO:0009081)3.54083598
136drug metabolic process (GO:0017144)3.53961668
137pyridine nucleotide biosynthetic process (GO:0019363)3.53621964
138nicotinamide nucleotide biosynthetic process (GO:0019359)3.53621964
139fatty acid catabolic process (GO:0009062)3.53583744
140plasma lipoprotein particle clearance (GO:0034381)3.53259602
141digestion (GO:0007586)3.47824796
142maintenance of gastrointestinal epithelium (GO:0030277)3.46689573
143regulation of cellular extravasation (GO:0002691)3.46179977
144positive regulation of fatty acid biosynthetic process (GO:0045723)3.44407569
145vitamin biosynthetic process (GO:0009110)3.39821362
146glycolipid catabolic process (GO:0019377)3.34854773
147glycosphingolipid catabolic process (GO:0046479)3.34647304
148cholesterol homeostasis (GO:0042632)3.34061559
149phenylpropanoid metabolic process (GO:0009698)3.33715215
150sterol homeostasis (GO:0055092)3.28909338
151adhesion of symbiont to host (GO:0044406)3.24580987
152fat-soluble vitamin metabolic process (GO:0006775)3.24070495
153renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.23431204
154phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.23300793
155heme transport (GO:0015886)3.15389670
156cellular response to nitric oxide (GO:0071732)3.13760567
157axonemal dynein complex assembly (GO:0070286)3.05322472
158antibacterial humoral response (GO:0019731)3.04044378
159regulation of vitamin metabolic process (GO:0030656)3.04002717
160regulation of cholesterol homeostasis (GO:2000188)3.03777096
161* vitamin transport (GO:0051180)3.02468807
162low-density lipoprotein particle remodeling (GO:0034374)3.01729515
163leukotriene metabolic process (GO:0006691)3.01121862
164xenobiotic metabolic process (GO:0006805)3.00868381
165regulation of cholesterol metabolic process (GO:0090181)3.00583963
166sodium ion homeostasis (GO:0055078)2.98363232
167phosphate ion transmembrane transport (GO:0035435)2.97481605
168proline biosynthetic process (GO:0006561)2.96631513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.16665106
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.95785842
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.85710175
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.30992610
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.81540536
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.72378364
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.47257203
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.94588294
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.85922627
10* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.26499116
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08553094
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2644122
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.96308848
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96272574
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82763947
16BP1_19119308_ChIP-ChIP_Hs578T_Human1.69003588
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.68117845
18LXR_22292898_ChIP-Seq_THP-1_Human1.66430376
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.60101749
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57265232
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55319146
22* HNF4A_19822575_ChIP-Seq_HepG2_Human1.52413842
23CLOCK_20551151_ChIP-Seq_293T_Human1.39246666
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33333884
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32140997
26BCOR_27268052_Chip-Seq_Bcells_Human1.28833532
27KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23518422
28HTT_18923047_ChIP-ChIP_STHdh_Human1.23480237
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.23214272
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22580128
31TCF4_18268006_ChIP-ChIP_LS174T_Human1.21000184
32BCL6_27268052_Chip-Seq_Bcells_Human1.19206303
33GATA1_19941826_ChIP-Seq_K562_Human1.17373137
34RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15876803
35* RACK7_27058665_Chip-Seq_MCF-7_Human1.12936124
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.12565959
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12514116
38GATA4_25053715_ChIP-Seq_YYC3_Human1.12188776
39* SA1_27219007_Chip-Seq_Bcells_Human1.11181532
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10342494
41ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10022189
42GATA1_22025678_ChIP-Seq_K562_Human1.08676356
43DROSHA_22980978_ChIP-Seq_HELA_Human1.07545816
44CTCF_27219007_Chip-Seq_Bcells_Human1.07408573
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07297032
46SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03966985
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02610410
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.00668326
49KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00550401
50SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00269435
51* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99706029
52TET1_21451524_ChIP-Seq_MESCs_Mouse0.97283190
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97249917
54PHF8_20622854_ChIP-Seq_HELA_Human0.97123586
55KLF5_25053715_ChIP-Seq_YYC3_Human0.97070572
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96663967
57RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94301199
58NANOG_20526341_ChIP-Seq_ESCs_Human0.93066401
59SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92525462
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92257403
61ESR2_21235772_ChIP-Seq_MCF-7_Human0.91419379
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90815545
63EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89905009
64TP63_22573176_ChIP-Seq_HFKS_Human0.89886731
65CDX2_20551321_ChIP-Seq_CACO-2_Human0.89658502
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89579309
67JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.89380346
68CREB1_26743006_Chip-Seq_LNCaP_Human0.88832047
69STAT1_20625510_ChIP-Seq_HELA_Human0.86929814
70E2F1_20622854_ChIP-Seq_HELA_Human0.85176789
71VDR_24763502_ChIP-Seq_THP-1_Human0.85038591
72* P300_27268052_Chip-Seq_Bcells_Human0.84732295
73CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84659893
74P68_20966046_ChIP-Seq_HELA_Human0.83098330
75RXR_22108803_ChIP-Seq_LS180_Human0.82898661
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82431598
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81932257
78ZNF263_19887448_ChIP-Seq_K562_Human0.81854768
79TP63_17297297_ChIP-ChIP_HaCaT_Human0.80408402
80SOX2_21211035_ChIP-Seq_LN229_Human0.80360356
81CTCF_20526341_ChIP-Seq_ESCs_Human0.79546318
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79338213
83GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79049903
84IRF8_21731497_ChIP-ChIP_J774_Mouse0.78877373
85SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78846492
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78439384
87VDR_24787735_ChIP-Seq_THP-1_Human0.78150087
88GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77540183
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76689119
90* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76470820
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76258163
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75028368
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72921000
94STAT1_17558387_ChIP-Seq_HELA_Human0.72503668
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.71840308
96RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70824269
97* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70582471
98AR_20517297_ChIP-Seq_VCAP_Human0.70094551
99* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69642139
100EGR1_19032775_ChIP-ChIP_M12_Human0.69508284
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69063828
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.68721610
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67747769
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67528768
105NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67528768
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64021664
107RARA_24833708_ChIP-Seq_LIVER_Mouse0.63460470
108IRF1_19129219_ChIP-ChIP_H3396_Human0.62639276
109CEBPB_22108803_ChIP-Seq_LS180_Human0.62396042
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60697277
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.60617467
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.59896581
113ESET_19884257_ChIP-Seq_ESCs_Mouse0.59177733
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.58645304
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57874427
116* MYC_19915707_ChIP-ChIP_AK7_Human0.56785104
117GATA6_25053715_ChIP-Seq_YYC3_Human0.55619696
118CDX2_22108803_ChIP-Seq_LS180_Human0.55163552
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54725010
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.54143524
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.53875942
122EZH2_27294783_Chip-Seq_NPCs_Mouse0.53362397
123CBP_21632823_ChIP-Seq_H3396_Human0.53260786
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.52658381
125RARB_24833708_ChIP-Seq_LIVER_Mouse0.52209814
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.51626854
127SOX2_20726797_ChIP-Seq_SW620_Human0.51436077
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.50591142
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.50350435
130CRX_20693478_ChIP-Seq_RETINA_Mouse0.50071117
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.50028695
132NFE2_27457419_Chip-Seq_LIVER_Mouse0.49997180
133PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49630225
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.49546326
135FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49328355
136TAF2_19829295_ChIP-Seq_ESCs_Human0.48368842
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.47778397
138NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.47520467
139* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47010754
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.46551573
141OCT4_21477851_ChIP-Seq_ESCs_Mouse0.46349119
142RUNX1_27457419_Chip-Seq_LIVER_Mouse0.44913108
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44182086
144FOXH1_21741376_ChIP-Seq_EPCs_Human0.43243876
145TAF15_26573619_Chip-Seq_HEK293_Human0.42247964
146SOX2_22085726_ChIP-Seq_NPCs_Mouse0.41253271
147CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.41195662
148HNFA_21074721_ChIP-Seq_CACO-2_Human0.41151407
149GATA3_24758297_ChIP-Seq_MCF-7_Human0.40917050
150GATA2_19941826_ChIP-Seq_K562_Human0.40289385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.33055943
2MP0002139_abnormal_hepatobiliary_system7.94506279
3MP0005085_abnormal_gallbladder_physiolo5.74384983
4MP0005365_abnormal_bile_salt5.62725318
5MP0008875_abnormal_xenobiotic_pharmacok5.07216366
6MP0003252_abnormal_bile_duct3.94906338
7MP0003806_abnormal_nucleotide_metabolis3.70545799
8MP0003195_calcinosis3.61847214
9MP0003183_abnormal_peptide_metabolism3.60378206
10MP0005332_abnormal_amino_acid3.55887383
11MP0010329_abnormal_lipoprotein_level3.05005427
12* MP0004019_abnormal_vitamin_homeostasis2.95720100
13MP0002138_abnormal_hepatobiliary_system2.76328677
14MP0009379_abnormal_foot_pigmentation2.54391424
15MP0009840_abnormal_foam_cell2.50804285
16MP0005083_abnormal_biliary_tract2.38924541
17MP0010155_abnormal_intestine_physiology2.25011531
18* MP0001666_abnormal_nutrient_absorption2.20555705
19MP0003191_abnormal_cellular_cholesterol2.18884231
20* MP0009643_abnormal_urine_homeostasis2.06927053
21MP0010234_abnormal_vibrissa_follicle1.92235105
22MP0004043_abnormal_pH_regulation1.90010397
23MP0002118_abnormal_lipid_homeostasis1.89514315
24MP0000609_abnormal_liver_physiology1.87616964
25MP0005409_darkened_coat_color1.82022440
26MP0005319_abnormal_enzyme/_coenzyme1.78093877
27MP0001764_abnormal_homeostasis1.73234649
28MP0005636_abnormal_mineral_homeostasis1.64058593
29MP0005584_abnormal_enzyme/coenzyme_acti1.60716592
30MP0003868_abnormal_feces_composition1.60390850
31MP0005451_abnormal_body_composition1.56680769
32MP0003186_abnormal_redox_activity1.50879436
33MP0001664_abnormal_digestion1.46541153
34MP0001756_abnormal_urination1.42002160
35MP0003866_abnormal_defecation1.39198706
36MP0002876_abnormal_thyroid_physiology1.35487264
37MP0000678_abnormal_parathyroid_gland1.30379894
38MP0000490_abnormal_crypts_of1.25149589
39* MP0002136_abnormal_kidney_physiology1.19395385
40MP0009697_abnormal_copulation1.18117433
41MP0009764_decreased_sensitivity_to1.15878006
42MP0001765_abnormal_ion_homeostasis1.15283148
43MP0005084_abnormal_gallbladder_morpholo1.13318234
44MP0000477_abnormal_intestine_morphology1.08614794
45MP0003879_abnormal_hair_cell1.06873096
46MP0000598_abnormal_liver_morphology1.03394643
47MP0005647_abnormal_sex_gland1.00106434
48MP0003011_delayed_dark_adaptation0.99026149
49MP0005670_abnormal_white_adipose0.91651177
50* MP0009642_abnormal_blood_homeostasis0.90553225
51MP0002254_reproductive_system_inflammat0.90320534
52MP0006036_abnormal_mitochondrial_physio0.90154006
53MP0005408_hypopigmentation0.89066446
54MP0008469_abnormal_protein_level0.88932398
55MP0002928_abnormal_bile_duct0.84332298
56MP0001661_extended_life_span0.84328908
57MP0010352_gastrointestinal_tract_polyps0.84255078
58MP0005220_abnormal_exocrine_pancreas0.83748331
59MP0009763_increased_sensitivity_to0.83409329
60MP0002822_catalepsy0.82577536
61MP0003656_abnormal_erythrocyte_physiolo0.81116467
62MP0001188_hyperpigmentation0.81105553
63MP0001663_abnormal_digestive_system0.79251336
64MP0009115_abnormal_fat_cell0.77585548
65MP0009765_abnormal_xenobiotic_induced0.76053054
66MP0005535_abnormal_body_temperature0.76009107
67MP0000462_abnormal_digestive_system0.75841232
68MP0000604_amyloidosis0.75011127
69MP0000538_abnormal_urinary_bladder0.73787525
70MP0002078_abnormal_glucose_homeostasis0.72568496
71MP0001873_stomach_inflammation0.69506535
72MP0005376_homeostasis/metabolism_phenot0.68948548
73MP0000249_abnormal_blood_vessel0.64780420
74MP0005058_abnormal_lysosome_morphology0.64725287
75MP0009785_altered_susceptibility_to0.63739238
76MP0002396_abnormal_hematopoietic_system0.62579946
77MP0002168_other_aberrant_phenotype0.62036223
78MP0003638_abnormal_response/metabolism_0.61426180
79MP0005381_digestive/alimentary_phenotyp0.61071198
80MP0010368_abnormal_lymphatic_system0.60909892
81MP0004264_abnormal_extraembryonic_tissu0.58325495
82MP0004270_analgesia0.57918507
83MP0003724_increased_susceptibility_to0.57584030
84MP0005334_abnormal_fat_pad0.57577244
85MP0000230_abnormal_systemic_arterial0.55998493
86MP0001501_abnormal_sleep_pattern0.55950795
87MP0004782_abnormal_surfactant_physiolog0.55040131
88MP0002971_abnormal_brown_adipose0.54651529
89MP0004858_abnormal_nervous_system0.54385763
90MP0006035_abnormal_mitochondrial_morpho0.53557856
91MP0005025_abnormal_response_to0.52532936
92MP0003705_abnormal_hypodermis_morpholog0.51558461
93MP0002135_abnormal_kidney_morphology0.51501758
94MP0001485_abnormal_pinna_reflex0.51322918
95* MP0005395_other_phenotype0.50720767
96MP0001835_abnormal_antigen_presentation0.50471833
97MP0002166_altered_tumor_susceptibility0.48451989
98MP0009053_abnormal_anal_canal0.46391876
99MP0003953_abnormal_hormone_level0.45891680
100MP0005266_abnormal_metabolism0.45724336
101MP0002796_impaired_skin_barrier0.45293038
102MP0003690_abnormal_glial_cell0.43725917
103MP0009333_abnormal_splenocyte_physiolog0.42238967
104MP0005367_renal/urinary_system_phenotyp0.41963710
105MP0000516_abnormal_urinary_system0.41963710
106MP0008260_abnormal_autophagy0.41562989
107MP0008961_abnormal_basal_metabolism0.39729528
108MP0005377_hearing/vestibular/ear_phenot0.39665818
109MP0003878_abnormal_ear_physiology0.39665818
110* MP0003718_maternal_effect0.38034227
111MP0002277_abnormal_respiratory_mucosa0.37327915
112MP0003303_peritoneal_inflammation0.37241324
113MP0000681_abnormal_thyroid_gland0.36939996
114MP0003300_gastrointestinal_ulcer0.36278855
115MP0005666_abnormal_adipose_tissue0.36050776
116MP0005464_abnormal_platelet_physiology0.35995771
117MP0001845_abnormal_inflammatory_respons0.34654355
118MP0005448_abnormal_energy_balance0.33733935
119MP0003329_amyloid_beta_deposits0.33687740
120MP0003436_decreased_susceptibility_to0.32153394
121MP0004147_increased_porphyrin_level0.31931525
122MP0006082_CNS_inflammation0.31582564
123MP0008873_increased_physiological_sensi0.31064054
124MP0000639_abnormal_adrenal_gland0.30502255
125MP0008874_decreased_physiological_sensi0.30080770
126MP0005166_decreased_susceptibility_to0.29402474
127MP0003959_abnormal_lean_body0.29385762
128MP0002098_abnormal_vibrissa_morphology0.29178598
129MP0008872_abnormal_physiological_respon0.29113104
130MP0009672_abnormal_birth_weight0.28956393
131MP0002132_abnormal_respiratory_system0.27612386
132MP0000566_synostosis0.26726304
133MP0000579_abnormal_nail_morphology0.26686663
134MP0004381_abnormal_hair_follicle0.26378420
135MP0003075_altered_response_to0.25959663
136MP0005248_abnormal_Harderian_gland0.25691332
137MP0004130_abnormal_muscle_cell0.25398413

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.42115211
2Intrahepatic cholestasis (HP:0001406)6.02757436
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.51213995
4Deep venous thrombosis (HP:0002625)5.49440597
5Xanthomatosis (HP:0000991)5.15043195
6Abnormality of glutamine family amino acid metabolism (HP:0010902)5.12895361
7Prolonged partial thromboplastin time (HP:0003645)5.12419912
8Hyperglycinuria (HP:0003108)5.12156489
9Hypobetalipoproteinemia (HP:0003563)4.93756446
10Abnormality of serine family amino acid metabolism (HP:0010894)4.67817271
11Abnormality of glycine metabolism (HP:0010895)4.67817271
12Hyperglycinemia (HP:0002154)4.54612604
13Abnormality of aspartate family amino acid metabolism (HP:0010899)4.51867912
14Gout (HP:0001997)4.47496267
15Widely patent fontanelles and sutures (HP:0004492)4.46540056
16Ketosis (HP:0001946)4.45275860
17Abnormality of the vitamin B12 metabolism (HP:0004341)4.43013029
18Hyperammonemia (HP:0001987)4.34366834
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.27324490
20Joint hemorrhage (HP:0005261)4.21523414
21Abnormality of vitamin B metabolism (HP:0004340)4.12427247
22Hyperlipoproteinemia (HP:0010980)4.12179537
23Chronic diarrhea (HP:0002028)4.11643486
24Complement deficiency (HP:0004431)4.00542997
25Acanthocytosis (HP:0001927)3.94412735
26Abnormality of vitamin metabolism (HP:0100508)3.89941274
27Abnormality of purine metabolism (HP:0004352)3.86599513
28Ketoacidosis (HP:0001993)3.82004866
29Abnormality of fatty-acid metabolism (HP:0004359)3.81866306
30Ileus (HP:0002595)3.76705016
31Abnormality of nucleobase metabolism (HP:0010932)3.73313902
32Delayed CNS myelination (HP:0002188)3.65685596
33Hypolipoproteinemia (HP:0010981)3.61462885
34Abnormality of methionine metabolism (HP:0010901)3.59136998
35Fat malabsorption (HP:0002630)3.59021508
36Proximal tubulopathy (HP:0000114)3.57733325
37Epidermoid cyst (HP:0200040)3.56347219
38Hypoglycemic coma (HP:0001325)3.53722816
39Conjugated hyperbilirubinemia (HP:0002908)3.48260687
40Abnormality of pyrimidine metabolism (HP:0004353)3.46742681
41Alkalosis (HP:0001948)3.42757530
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.42724199
43Abnormality of the common coagulation pathway (HP:0010990)3.42047117
44Increased purine levels (HP:0004368)3.38952995
45Hyperuricemia (HP:0002149)3.38952995
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.27887909
47Abnormal respiratory epithelium morphology (HP:0012253)3.20638800
48Abnormal respiratory motile cilium morphology (HP:0005938)3.20638800
49Hyperactive renin-angiotensin system (HP:0000841)3.16292922
50Vascular calcification (HP:0004934)3.13116383
51Hypokalemic alkalosis (HP:0001949)3.12775607
52Metabolic acidosis (HP:0001942)3.12256509
53Abnormality of serum amino acid levels (HP:0003112)3.09679247
54Generalized aminoaciduria (HP:0002909)3.08576231
55Pigmentary retinal degeneration (HP:0001146)3.08559529
56Facial shape deformation (HP:0011334)3.07886983
57Potter facies (HP:0002009)3.07886983
58Wide cranial sutures (HP:0010537)3.07547654
59Hypoalphalipoproteinemia (HP:0003233)3.07211503
60Hemorrhage of the eye (HP:0011885)3.06182557
61Dynein arm defect of respiratory motile cilia (HP:0012255)3.04441507
62Absent/shortened dynein arms (HP:0200106)3.04441507
63Abnormal respiratory motile cilium physiology (HP:0012261)2.96391552
64Abnormal ciliary motility (HP:0012262)2.96303219
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.94940556
66Dicarboxylic aciduria (HP:0003215)2.94940556
67Hyperbilirubinemia (HP:0002904)2.93518657
68Metabolic alkalosis (HP:0200114)2.91854494
69Increased circulating renin level (HP:0000848)2.90737800
70Abnormality of the intrinsic pathway (HP:0010989)2.89629237
71Decreased circulating renin level (HP:0003351)2.88614219
72Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.87616777
73Abnormality of complement system (HP:0005339)2.85298025
74Rhinitis (HP:0012384)2.83201673
75Lethargy (HP:0001254)2.81628348
76Hypophosphatemia (HP:0002148)2.80565188
77Megaloblastic anemia (HP:0001889)2.80068634
78Thin bony cortex (HP:0002753)2.78801591
79Hepatocellular carcinoma (HP:0001402)2.76236134
80Cardiovascular calcification (HP:0011915)2.74231015
81Hypercholesterolemia (HP:0003124)2.73817849
82Abnormal urine phosphate concentration (HP:0012599)2.73256907
83Glycosuria (HP:0003076)2.72853153
84Abnormality of urine glucose concentration (HP:0011016)2.72853153
85Hypomagnesemia (HP:0002917)2.72762442
86Steatorrhea (HP:0002570)2.70576028
87Abnormal urine output (HP:0012590)2.69862485
88Malnutrition (HP:0004395)2.69085392
89Nasal polyposis (HP:0100582)2.65528326
90Enlarged kidneys (HP:0000105)2.63247914
91Abnormality of chloride homeostasis (HP:0011422)2.62815187
92Polyuria (HP:0000103)2.57132643
93Abnormality of proline metabolism (HP:0010907)2.54080930
94Hydroxyprolinuria (HP:0003080)2.54080930
95Vomiting (HP:0002013)2.52468838
96Abdominal distention (HP:0003270)2.48791751
97Rickets (HP:0002748)2.48104636
98Abnormality of renal excretion (HP:0011036)2.46668786
99Congenital sensorineural hearing impairment (HP:0008527)2.45209043
100Irritability (HP:0000737)2.40519448
101Hypotension (HP:0002615)2.38027556
102Systemic lupus erythematosus (HP:0002725)2.37277179
103Bronchiectasis (HP:0002110)2.36551033
104Cerebral edema (HP:0002181)2.30997017
105Abnormality of the nasal mucosa (HP:0000433)2.30176158
106Myocardial infarction (HP:0001658)2.29784936
107Abnormality of magnesium homeostasis (HP:0004921)2.26721466
108Abnormality of renin-angiotensin system (HP:0000847)2.26567474
109Hypoglycemic seizures (HP:0002173)2.23364358
110Renal tubular acidosis (HP:0001947)2.22879846
111Nephritis (HP:0000123)2.20394025
112Neonatal onset (HP:0003623)2.20187476
113Confusion (HP:0001289)2.19103278
114Abnormal enzyme/coenzyme activity (HP:0012379)2.18903072
115Hypochromic microcytic anemia (HP:0004840)2.18664294
116Posterior subcapsular cataract (HP:0007787)2.17647777
117Nephrolithiasis (HP:0000787)2.17072816
118Spastic diplegia (HP:0001264)2.16401418
119Pancreatitis (HP:0001733)2.14870945
120Renal cortical cysts (HP:0000803)2.14264708
121Glomerulonephritis (HP:0000099)2.13383932
122Spontaneous abortion (HP:0005268)2.11631338
123Mitral stenosis (HP:0001718)2.11002692
124Hypophosphatemic rickets (HP:0004912)2.09942030
125Sensorimotor neuropathy (HP:0007141)2.09625095
126Late onset (HP:0003584)2.09106330
127Abnormality of small intestinal villus morphology (HP:0011472)2.07520609
128Villous atrophy (HP:0011473)2.07520609
129Focal segmental glomerulosclerosis (HP:0000097)2.07188002
130Chronic bronchitis (HP:0004469)2.06414973
131Tetany (HP:0001281)2.04763645
132Hyperphosphaturia (HP:0003109)2.04524478
133Poikilocytosis (HP:0004447)2.02183052
134Enlarged epiphyses (HP:0010580)2.01410501
135Delayed epiphyseal ossification (HP:0002663)1.99786794
136Opisthotonus (HP:0002179)1.99652448
137Recurrent sinusitis (HP:0011108)1.99540494
138Abnormality of alkaline phosphatase activity (HP:0004379)1.98001747
139Abnormal glucose tolerance (HP:0001952)1.97205968
140Renal salt wasting (HP:0000127)1.95434194
141Skin nodule (HP:0200036)1.94900831
142Nausea (HP:0002018)1.94063856
143Hyperaldosteronism (HP:0000859)1.93120607
144Protuberant abdomen (HP:0001538)1.87856128
145Abnormality of the costochondral junction (HP:0000919)1.85440948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.54110253
2BCKDK6.30024559
3WNK35.69460708
4OXSR13.96540948
5WNK43.95216967
6FGFR43.67886573
7SIK12.96969625
8INSRR2.90263909
9ERN12.90102263
10PRKG22.85099883
11STK38L2.51790274
12MAP3K102.43800994
13TAOK32.39999526
14MAP3K22.37077666
15MST42.11419768
16MST1R2.01701749
17ERBB41.96006079
18IRAK31.78707620
19TESK21.78187144
20MAP3K141.66078051
21LATS11.64766509
22PINK11.61008906
23PIK3CG1.56898242
24SGK4941.48386983
25SGK2231.48386983
26MAPK111.47207304
27MAP4K11.46238710
28RIPK41.45347721
29SGK21.40727587
30FRK1.40475702
31EPHA41.33819356
32SGK31.28941712
33TYK21.25182087
34MAP2K41.21253640
35MATK1.15935030
36TIE11.14490217
37ABL21.12903000
38STK391.12808901
39MAP3K31.12142986
40NEK91.10023890
41FLT31.07986769
42PRKAA21.04968585
43STK241.01903857
44PIK3CA1.01378901
45MAP3K71.00918461
46GRK61.00843312
47MAP3K10.97862253
48DDR20.95798439
49MAPK150.95317336
50SMG10.92055843
51MAP2K30.91512020
52MAP2K20.91266257
53TRIB30.88527484
54PTK60.86824612
55TGFBR20.83701190
56CDC42BPA0.83649491
57PRPF4B0.81415902
58JAK20.81311327
59PDK10.81303291
60MAP3K120.80952980
61PRKAA10.79866977
62STK160.79308848
63EEF2K0.76995444
64GSK3A0.76455399
65IRAK10.76337782
66PDK30.75830864
67PDK40.75830864
68IRAK20.74957242
69DAPK20.72915952
70PRKCZ0.72530019
71KDR0.72147160
72GRK10.71272740
73EPHB10.71003989
74PDK20.70169898
75ZAK0.69699211
76ERBB20.64849003
77DYRK1B0.64691376
78TNIK0.64334457
79JAK10.63400785
80FGFR20.62632445
81STK380.61685102
82IKBKE0.61047599
83NEK60.59442612
84RET0.58779444
85MAPK40.57012287
86MAP2K60.56575961
87TBK10.56462324
88PRKACG0.56381529
89CSK0.56015217
90AKT30.54878104
91FER0.54037694
92NUAK10.53697565
93MAPKAPK30.51294263
94MAP3K110.50323572
95EPHB20.48920235
96TESK10.48556782
97CSF1R0.48351397
98PIM10.47858420
99TAOK20.47544940
100ICK0.46109395
101MET0.46049758
102TAOK10.45918421
103SRC0.45831128
104PTK20.44074313
105LMTK20.43596019
106MAPK120.43147054
107PRKCQ0.41430687
108YES10.39436729
109NME10.39295989
110KSR20.39243695
111FYN0.38277629
112PDPK10.37508617
113CAMK2G0.37141215
114MAPK70.36968717
115PRKCI0.35520672
116EPHA30.35322689
117ZAP700.35171184
118PKN20.34264818
119LYN0.34170006
120SYK0.33546648
121MELK0.33177671
122NEK10.33140415
123PBK0.32544702
124IGF1R0.32153411
125CDK60.31588808
126CHUK0.29657745
127FGFR30.29618191
128PRKACA0.29322936
129TEC0.28760625
130MYLK0.28699820
131SGK10.28280090
132LRRK20.28245310
133PRKCA0.27663151
134LCK0.27580458
135NLK0.26204244
136RIPK10.26028253
137BLK0.25819415
138PRKCD0.24799717
139BMPR20.24725640
140MAP3K50.23179668
141CSNK1G10.22864814
142IRAK40.22138899
143ITK0.22068266
144CDK90.21881077
145PKN10.21800017
146WNK10.21167764
147EPHA20.19466072
148MAP3K60.18636716
149BTK0.18584841
150CAMK40.18543014

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.85436408
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.45646223
3Nitrogen metabolism_Homo sapiens_hsa009102.89278048
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.87776160
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.84314804
6Tryptophan metabolism_Homo sapiens_hsa003802.82129293
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.69113920
8Arginine biosynthesis_Homo sapiens_hsa002202.69082638
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56395299
10Butanoate metabolism_Homo sapiens_hsa006502.54257749
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.54111619
12Fatty acid degradation_Homo sapiens_hsa000712.51905979
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49762611
14Peroxisome_Homo sapiens_hsa041462.37231997
15Propanoate metabolism_Homo sapiens_hsa006402.27350457
16Complement and coagulation cascades_Homo sapiens_hsa046102.20221629
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11737345
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10971468
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95645283
20beta-Alanine metabolism_Homo sapiens_hsa004101.95505587
21Histidine metabolism_Homo sapiens_hsa003401.89021771
22Chemical carcinogenesis_Homo sapiens_hsa052041.87531759
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86521156
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.84587911
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.81929204
26Fatty acid metabolism_Homo sapiens_hsa012121.81841380
27PPAR signaling pathway_Homo sapiens_hsa033201.78121960
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.77692949
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.64223144
30Retinol metabolism_Homo sapiens_hsa008301.62452787
31Bile secretion_Homo sapiens_hsa049761.61046427
32Selenocompound metabolism_Homo sapiens_hsa004501.59922061
33Sulfur metabolism_Homo sapiens_hsa009201.56385888
34Pyruvate metabolism_Homo sapiens_hsa006201.55555374
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49944377
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47855562
37Phenylalanine metabolism_Homo sapiens_hsa003601.45843894
38Staphylococcus aureus infection_Homo sapiens_hsa051501.39341939
39Caffeine metabolism_Homo sapiens_hsa002321.38192692
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34752654
41Starch and sucrose metabolism_Homo sapiens_hsa005001.34532979
42Fatty acid elongation_Homo sapiens_hsa000621.30438115
43Tyrosine metabolism_Homo sapiens_hsa003501.28630254
44Folate biosynthesis_Homo sapiens_hsa007901.23947792
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23243671
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.21282187
47Carbon metabolism_Homo sapiens_hsa012001.20441369
48* Vitamin digestion and absorption_Homo sapiens_hsa049771.19188498
49ABC transporters_Homo sapiens_hsa020101.14013587
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13678455
51Biosynthesis of amino acids_Homo sapiens_hsa012301.13070700
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.12812729
53Arginine and proline metabolism_Homo sapiens_hsa003301.12524497
54Steroid biosynthesis_Homo sapiens_hsa001001.11341499
55Lysine degradation_Homo sapiens_hsa003101.05688259
56Glutathione metabolism_Homo sapiens_hsa004801.03410062
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94983581
58Fat digestion and absorption_Homo sapiens_hsa049750.92003791
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91752748
60Sulfur relay system_Homo sapiens_hsa041220.82861093
61Sphingolipid metabolism_Homo sapiens_hsa006000.77520810
62Vitamin B6 metabolism_Homo sapiens_hsa007500.76035202
63One carbon pool by folate_Homo sapiens_hsa006700.75617925
64Glycerolipid metabolism_Homo sapiens_hsa005610.73084516
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72795699
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70652253
67Ether lipid metabolism_Homo sapiens_hsa005650.67240140
68Asthma_Homo sapiens_hsa053100.65425428
69Pentose phosphate pathway_Homo sapiens_hsa000300.54569485
70Metabolic pathways_Homo sapiens_hsa011000.54303454
71Allograft rejection_Homo sapiens_hsa053300.46876665
72Autoimmune thyroid disease_Homo sapiens_hsa053200.41632834
73Fructose and mannose metabolism_Homo sapiens_hsa000510.39475679
74Graft-versus-host disease_Homo sapiens_hsa053320.37866165
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26687436
76Type I diabetes mellitus_Homo sapiens_hsa049400.26568388
77Fatty acid biosynthesis_Homo sapiens_hsa000610.26525477
78Galactose metabolism_Homo sapiens_hsa000520.25952528
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25587505
80Pancreatic secretion_Homo sapiens_hsa049720.24830483
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23267317
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17081024
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14611716
84Insulin resistance_Homo sapiens_hsa049310.12939574
85Other glycan degradation_Homo sapiens_hsa005110.12308545
86Mineral absorption_Homo sapiens_hsa049780.12307611
87Linoleic acid metabolism_Homo sapiens_hsa005910.11613384
88Renin-angiotensin system_Homo sapiens_hsa046140.11079321
89Arachidonic acid metabolism_Homo sapiens_hsa005900.09003655
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.08231619
91Cocaine addiction_Homo sapiens_hsa050300.08186145
92Protein digestion and absorption_Homo sapiens_hsa049740.08174674
93Renin secretion_Homo sapiens_hsa049240.06983644
94Antigen processing and presentation_Homo sapiens_hsa046120.06906443
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.06847043
96Pertussis_Homo sapiens_hsa051330.06309874
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.05029089
98Prion diseases_Homo sapiens_hsa050200.04400250
99Hematopoietic cell lineage_Homo sapiens_hsa046400.00871498
100Serotonergic synapse_Homo sapiens_hsa047260.00567230
101Insulin signaling pathway_Homo sapiens_hsa04910-0.2373034
102Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.2363796
103Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2129018
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.2011155
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1819194
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1391296
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1332892
108Collecting duct acid secretion_Homo sapiens_hsa04966-0.1238762
109Hepatitis C_Homo sapiens_hsa05160-0.1153741
110Regulation of autophagy_Homo sapiens_hsa04140-0.0856758
111AMPK signaling pathway_Homo sapiens_hsa04152-0.0700486
112Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0641922
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0572165
114Lysosome_Homo sapiens_hsa04142-0.0507998
115Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0479747
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0352424
117Glucagon signaling pathway_Homo sapiens_hsa04922-0.0305927
118Leishmaniasis_Homo sapiens_hsa05140-0.0190246
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0090577

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