SLC23A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.01265328
2locomotory exploration behavior (GO:0035641)4.78118374
3synaptic vesicle maturation (GO:0016188)4.77196581
4cellular potassium ion homeostasis (GO:0030007)4.35021089
5glutamate secretion (GO:0014047)4.29473210
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.08523905
7synaptic vesicle exocytosis (GO:0016079)4.07933715
8cholesterol efflux (GO:0033344)4.06158849
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.06007739
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.03570252
11vocalization behavior (GO:0071625)4.02778828
12regulation of synaptic vesicle exocytosis (GO:2000300)3.97511466
13negative regulation of fibrinolysis (GO:0051918)3.95115473
14regulation of protein activation cascade (GO:2000257)3.81381024
15complement activation, alternative pathway (GO:0006957)3.81100122
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.79371604
17regulation of apoptotic cell clearance (GO:2000425)3.78943631
18regulation of complement activation (GO:0030449)3.77954077
19regulation of glutamate receptor signaling pathway (GO:1900449)3.65930755
20plasma lipoprotein particle assembly (GO:0034377)3.64664467
21very-low-density lipoprotein particle assembly (GO:0034379)3.60779519
22gamma-aminobutyric acid transport (GO:0015812)3.60372807
23sodium ion export (GO:0071436)3.58726223
24proline transport (GO:0015824)3.56650745
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.55610072
26regulation of cholesterol esterification (GO:0010872)3.54991036
27low-density lipoprotein particle remodeling (GO:0034374)3.54725931
28regulation of synaptic vesicle transport (GO:1902803)3.51855803
29protein-lipid complex assembly (GO:0065005)3.49497172
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.47621416
31glucocorticoid metabolic process (GO:0008211)3.46805996
32regulation of fibrinolysis (GO:0051917)3.45833224
33neurotransmitter secretion (GO:0007269)3.44956246
34regulation of cholesterol homeostasis (GO:2000188)3.41879910
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39105929
36regulation of cholesterol biosynthetic process (GO:0045540)3.38427648
37regulation of neuronal synaptic plasticity (GO:0048168)3.36494183
38regulation of clathrin-mediated endocytosis (GO:2000369)3.36450392
39layer formation in cerebral cortex (GO:0021819)3.33421535
40neurotransmitter-gated ion channel clustering (GO:0072578)3.32563112
41protein-lipid complex remodeling (GO:0034368)3.31871293
42macromolecular complex remodeling (GO:0034367)3.31871293
43plasma lipoprotein particle remodeling (GO:0034369)3.31871293
44cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.30990497
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.28856416
46neuronal action potential propagation (GO:0019227)3.27390912
47L-amino acid import (GO:0043092)3.22654039
48exploration behavior (GO:0035640)3.22301280
49reverse cholesterol transport (GO:0043691)3.21388130
50synaptic transmission, glutamatergic (GO:0035249)3.15280339
51glutamate receptor signaling pathway (GO:0007215)3.13198636
52high-density lipoprotein particle remodeling (GO:0034375)3.12941513
53plasma lipoprotein particle organization (GO:0071827)3.11869449
54peptidyl-glutamic acid carboxylation (GO:0017187)3.10896641
55protein carboxylation (GO:0018214)3.10896641
56progesterone metabolic process (GO:0042448)3.08331583
57plasma lipoprotein particle clearance (GO:0034381)3.07777433
58response to follicle-stimulating hormone (GO:0032354)3.07309105
59protein-lipid complex subunit organization (GO:0071825)3.06796077
60dicarboxylic acid biosynthetic process (GO:0043650)3.05898865
61phospholipid efflux (GO:0033700)3.05774168
62synaptic vesicle endocytosis (GO:0048488)3.03787838
63negative regulation of sterol transport (GO:0032372)3.03142820
64negative regulation of cholesterol transport (GO:0032375)3.03142820
65glucocorticoid biosynthetic process (GO:0006704)3.02612960
66protein localization to synapse (GO:0035418)3.01701010
67long-term memory (GO:0007616)3.01672130
68regulation of synapse structural plasticity (GO:0051823)3.01349724
69C21-steroid hormone metabolic process (GO:0008207)2.99910288
70low-density lipoprotein particle clearance (GO:0034383)2.98394453
71positive regulation of steroid metabolic process (GO:0045940)2.96691960
72long-term synaptic potentiation (GO:0060291)2.93878655
73cerebellar Purkinje cell differentiation (GO:0021702)2.93765911
74gamma-aminobutyric acid signaling pathway (GO:0007214)2.93743479
75neuron-neuron synaptic transmission (GO:0007270)2.92044774
76triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.90630588
77neuron cell-cell adhesion (GO:0007158)2.88802856
78regulation of cholesterol storage (GO:0010885)2.86212156
79positive regulation by symbiont of host defense response (GO:0052509)2.84024152
80modulation by symbiont of host defense response (GO:0052031)2.84024152
81modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84024152
82modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84024152
83positive regulation by organism of defense response of other organism involved in symbiotic interact2.84024152
84modulation by symbiont of host immune response (GO:0052553)2.84024152
85potassium ion import (GO:0010107)2.83908986
86regulation of excitatory postsynaptic membrane potential (GO:0060079)2.83696811
87regulation of ARF protein signal transduction (GO:0032012)2.81369737
88response to methylmercury (GO:0051597)2.80474154
89vesicle transport along microtubule (GO:0047496)2.79641572
90neuromuscular process controlling balance (GO:0050885)2.78642998
91regulation of synaptic plasticity (GO:0048167)2.78579872
92alanine transport (GO:0032328)2.76606473
93amino acid import (GO:0043090)2.74108454
94response to auditory stimulus (GO:0010996)2.73004370
95positive regulation of extracellular matrix organization (GO:1903055)2.72426520
96neurotransmitter transport (GO:0006836)2.71710949
97positive regulation of synapse maturation (GO:0090129)2.70396819
98regulation of postsynaptic membrane potential (GO:0060078)2.70255875
99nerve growth factor signaling pathway (GO:0038180)2.70022055
100macrophage activation involved in immune response (GO:0002281)2.68915060
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.67736283
102glutamate metabolic process (GO:0006536)2.67653844
103response to histamine (GO:0034776)2.67356175
104intestinal cholesterol absorption (GO:0030299)2.66991781
105activation of protein kinase A activity (GO:0034199)2.66734864
106androgen biosynthetic process (GO:0006702)2.66672494
107cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.65071305
108regulation of synaptic transmission, glutamatergic (GO:0051966)2.63753678
109detection of molecule of bacterial origin (GO:0032490)2.63309118
110cytoskeletal anchoring at plasma membrane (GO:0007016)2.62042615
111sterol transport (GO:0015918)2.61354944
112cholesterol transport (GO:0030301)2.61354944
113regulation of beta-amyloid formation (GO:1902003)2.60389033
114chondroitin sulfate catabolic process (GO:0030207)2.59579812
115neuromuscular process controlling posture (GO:0050884)2.58343566
116positive regulation of steroid biosynthetic process (GO:0010893)2.58234206
117positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.57651149
118dendrite morphogenesis (GO:0048813)2.57380015
119cellular sodium ion homeostasis (GO:0006883)2.56262077
120mating behavior (GO:0007617)2.55908279
121neuronal ion channel clustering (GO:0045161)2.55361514
122protein localization to endosome (GO:0036010)2.54602870
123regulation of neurotransmitter secretion (GO:0046928)2.54544092
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.54087588
125C21-steroid hormone biosynthetic process (GO:0006700)2.53008609
126potassium ion homeostasis (GO:0055075)2.52584140
127regulation of neurotransmitter levels (GO:0001505)2.51191342
128transmission of nerve impulse (GO:0019226)2.50082275
129positive regulation of nitric-oxide synthase activity (GO:0051000)2.48510015
130regulation of amyloid precursor protein catabolic process (GO:1902991)2.47786791
131L-phenylalanine catabolic process (GO:0006559)2.46541931
132erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.46541931
133cerebellar granule cell differentiation (GO:0021707)2.46533841
134oligosaccharide catabolic process (GO:0009313)2.46210742
135G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44504907
136positive regulation of phagocytosis (GO:0050766)2.43787670
137negative regulation of lipid transport (GO:0032369)2.42822018
138positive regulation of cellular amide metabolic process (GO:0034250)2.42466735
139cell communication by electrical coupling (GO:0010644)2.42233210
140membrane depolarization during action potential (GO:0086010)2.41326922
141positive regulation of membrane potential (GO:0045838)2.40428543
142glycosphingolipid catabolic process (GO:0046479)2.38329083
143negative regulation of amino acid transport (GO:0051956)2.37167012
144regulation of cellular amide metabolic process (GO:0034248)2.36880018
145negative regulation of synaptic transmission, GABAergic (GO:0032229)2.36801513
146blood coagulation, intrinsic pathway (GO:0007597)2.36263041
147clathrin coat assembly (GO:0048268)2.36150668
148negative regulation of cell killing (GO:0031342)2.36120467
149negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.36120467
150axonal fasciculation (GO:0007413)2.35680844
151regulation of macrophage chemotaxis (GO:0010758)2.35403058
152positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.35273781
153axon ensheathment in central nervous system (GO:0032291)2.34282440
154central nervous system myelination (GO:0022010)2.34282440
155positive regulation of synaptic transmission (GO:0050806)2.34039799
156positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.33615329
157regulation of cholesterol metabolic process (GO:0090181)2.33199189
158glycine transport (GO:0015816)2.33041431
159erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.32424673
160L-phenylalanine metabolic process (GO:0006558)2.32424673
161G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.32091367
162regulation of neurotransmitter transport (GO:0051588)2.31854475
163membrane depolarization (GO:0051899)2.31760746
164regulation of steroid hormone biosynthetic process (GO:0090030)2.30869302
165negative regulation of protein activation cascade (GO:2000258)2.30118078
166positive regulation of Rap GTPase activity (GO:0032854)2.30096627
167innervation (GO:0060384)2.29575973
168complement activation, classical pathway (GO:0006958)2.28082748
169positive regulation of hormone biosynthetic process (GO:0046886)2.27588826
170neuromuscular process (GO:0050905)2.27478885
171regulation of vesicle fusion (GO:0031338)2.26855229
172neuron recognition (GO:0008038)2.26407192
173long term synaptic depression (GO:0060292)2.24672752

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.39681995
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.13421876
3GBX2_23144817_ChIP-Seq_PC3_Human2.57487765
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.39322948
5* FOXA2_19822575_ChIP-Seq_HepG2_Human2.30762734
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26818933
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26737646
8DROSHA_22980978_ChIP-Seq_HELA_Human2.23645705
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.07273517
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.06037104
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.04808628
12* LXR_22158963_ChIP-Seq_LIVER_Mouse2.01896153
13MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98066100
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97636607
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96765501
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.96245165
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95851576
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95851576
19IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89889712
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88805456
21REST_21632747_ChIP-Seq_MESCs_Mouse1.87051707
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84821119
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81692291
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73806723
25LXR_22292898_ChIP-Seq_THP-1_Human1.72326171
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66982186
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66781864
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63086298
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60873381
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.58194914
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58181403
32CLOCK_20551151_ChIP-Seq_293T_Human1.53055399
33TP53_16413492_ChIP-PET_HCT116_Human1.51160411
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50290675
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50093432
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49349197
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.47691826
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45240586
39SMAD4_21799915_ChIP-Seq_A2780_Human1.44446702
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43826222
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43165190
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.39987425
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.39295413
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38738256
45AR_21572438_ChIP-Seq_LNCaP_Human1.38513210
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37143475
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35513479
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.34304587
49AHR_22903824_ChIP-Seq_MCF-7_Human1.34230475
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.30717348
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29387355
52TCF7_22412390_ChIP-Seq_EML_Mouse1.26538822
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.25948519
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24608307
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24440985
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23602574
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23221357
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22963179
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22913496
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22222988
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22044867
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.21937582
63* KDM2B_26808549_Chip-Seq_K562_Human1.21548347
64TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21296397
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20457706
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.20135124
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19233337
68* KDM2B_26808549_Chip-Seq_DND41_Human1.18736286
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18379584
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.18211812
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.17676480
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17631682
73* HNF4A_19822575_ChIP-Seq_HepG2_Human1.15525889
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15424631
75RXR_22108803_ChIP-Seq_LS180_Human1.15355190
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14874856
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14522078
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13958536
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13075748
80* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12787230
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12683270
82AR_25329375_ChIP-Seq_VCAP_Human1.12511161
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.12373170
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12364509
85STAT3_23295773_ChIP-Seq_U87_Human1.11928040
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11657949
87* MITF_21258399_ChIP-Seq_MELANOMA_Human1.11193772
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10117418
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09876469
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09532999
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08915929
92* AR_19668381_ChIP-Seq_PC3_Human1.08593966
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08257981
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08257981
95SMAD3_21741376_ChIP-Seq_HESCs_Human1.07814844
96P300_19829295_ChIP-Seq_ESCs_Human1.05889165
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05446552
98* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04128554
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03492082
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.03225026
101CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02796981
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.02712758
103SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01920261
104TAF15_26573619_Chip-Seq_HEK293_Human1.01624777
105GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00434576
106MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00186544
107GATA2_21666600_ChIP-Seq_HMVEC_Human1.00117759
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99881685
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99669682
110* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98685390
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98433154
112* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98100070
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97911338
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.97652959
115* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97445537
116TBX20_22080862_ChIP-Seq_HEART_Mouse0.96677083
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.96677083
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96654784
119SMC4_20622854_ChIP-Seq_HELA_Human0.96537192
120TP53_18474530_ChIP-ChIP_U2OS_Human0.95686172
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95461671
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95214668
123FOXO3_23340844_ChIP-Seq_DLD1_Human0.94469896
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93744875
125E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93276418
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.93218213
127MYC_22102868_ChIP-Seq_BL_Human0.91485593
128* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91362019
129BP1_19119308_ChIP-ChIP_Hs578T_Human0.91135120
130VDR_24787735_ChIP-Seq_THP-1_Human0.90144360
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.90013916
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89992399
133* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89163088
134GATA1_19941826_ChIP-Seq_K562_Human0.88225602
135BCAT_22108803_ChIP-Seq_LS180_Human0.88003272
136YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87940357
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87372230
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.87008844
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86275092
140TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86210078
141RUNX_20019798_ChIP-Seq_JUKART_Human0.85908114
142GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85884669
143NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85866984
144TCF4_23295773_ChIP-Seq_U87_Human0.85590618
145SPI1_23127762_ChIP-Seq_K562_Human0.85322560
146ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85028020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.33183857
2MP0003635_abnormal_synaptic_transmissio3.64405853
3MP0000569_abnormal_digit_pigmentation3.51198365
4MP0003880_abnormal_central_pattern3.37761092
5MP0002139_abnormal_hepatobiliary_system3.18465481
6MP0009745_abnormal_behavioral_response3.06374469
7MP0002064_seizures3.04633819
8MP0009046_muscle_twitch2.99112948
9MP0005365_abnormal_bile_salt2.93526064
10MP0002063_abnormal_learning/memory/cond2.86919029
11MP0001501_abnormal_sleep_pattern2.69199407
12MP0003172_abnormal_lysosome_physiology2.67611948
13MP0004270_analgesia2.60606266
14MP0003690_abnormal_glial_cell2.59481799
15MP0005409_darkened_coat_color2.47350416
16MP0002572_abnormal_emotion/affect_behav2.34610013
17MP0004858_abnormal_nervous_system2.30996410
18MP0001968_abnormal_touch/_nociception2.26919463
19MP0003303_peritoneal_inflammation2.19635414
20MP0005257_abnormal_intraocular_pressure2.13269231
21MP0003075_altered_response_to2.11382459
22MP0002734_abnormal_mechanical_nocicepti2.06411751
23MP0002822_catalepsy2.00348029
24MP0003329_amyloid_beta_deposits1.99162094
25MP0001486_abnormal_startle_reflex1.95044924
26MP0000604_amyloidosis1.93751946
27MP0005167_abnormal_blood-brain_barrier1.92897242
28MP0002272_abnormal_nervous_system1.91515357
29MP0009780_abnormal_chondrocyte_physiolo1.90527062
30MP0005058_abnormal_lysosome_morphology1.87753366
31MP0004510_myositis1.87238126
32MP0003195_calcinosis1.84540319
33MP0010329_abnormal_lipoprotein_level1.82526956
34MP0005423_abnormal_somatic_nervous1.79885120
35MP0002736_abnormal_nociception_after1.77665944
36MP0001440_abnormal_grooming_behavior1.75140108
37MP0002090_abnormal_vision1.74366074
38* MP0002909_abnormal_adrenal_gland1.63590740
39MP0003633_abnormal_nervous_system1.63406754
40MP0008569_lethality_at_weaning1.62433798
41MP0010368_abnormal_lymphatic_system1.60648678
42* MP0000639_abnormal_adrenal_gland1.58686635
43MP0002733_abnormal_thermal_nociception1.55244676
44MP0002067_abnormal_sensory_capabilities1.54860993
45MP0001970_abnormal_pain_threshold1.49258199
46MP0002735_abnormal_chemical_nociception1.46563038
47MP0003123_paternal_imprinting1.45876240
48MP0003868_abnormal_feces_composition1.42343852
49MP0003183_abnormal_peptide_metabolism1.39865359
50MP0004811_abnormal_neuron_physiology1.38603536
51MP0001502_abnormal_circadian_rhythm1.38090421
52MP0005408_hypopigmentation1.37896234
53MP0005646_abnormal_pituitary_gland1.35244694
54MP0006082_CNS_inflammation1.34305293
55MP0005451_abnormal_body_composition1.34294133
56MP0004924_abnormal_behavior1.31364446
57MP0005386_behavior/neurological_phenoty1.31364446
58MP0002557_abnormal_social/conspecific_i1.30987923
59MP0003879_abnormal_hair_cell1.29905751
60MP0001984_abnormal_olfaction1.28720523
61MP0008961_abnormal_basal_metabolism1.27551980
62MP0003631_nervous_system_phenotype1.27492241
63MP0008260_abnormal_autophagy1.25928058
64MP0005166_decreased_susceptibility_to1.22457810
65MP0005085_abnormal_gallbladder_physiolo1.21222802
66MP0005360_urolithiasis1.19889979
67* MP0001915_intracranial_hemorrhage1.17918466
68MP0002089_abnormal_postnatal_growth/wei1.16608841
69MP0003634_abnormal_glial_cell1.16306455
70MP0002184_abnormal_innervation1.13368686
71MP0003878_abnormal_ear_physiology1.09921559
72MP0005377_hearing/vestibular/ear_phenot1.09921559
73MP0002066_abnormal_motor_capabilities/c1.06764203
74MP0003045_fibrosis1.05947162
75MP0002882_abnormal_neuron_morphology1.03919928
76MP0002118_abnormal_lipid_homeostasis1.03248687
77MP0003632_abnormal_nervous_system1.02796945
78MP0004885_abnormal_endolymph1.02592217
79MP0003787_abnormal_imprinting1.02227824
80MP0000778_abnormal_nervous_system1.01049468
81MP0002332_abnormal_exercise_endurance0.99289784
82MP0000920_abnormal_myelination0.98813783
83MP0000955_abnormal_spinal_cord0.98743839
84MP0000371_diluted_coat_color0.98485453
85MP0008874_decreased_physiological_sensi0.94732657
86MP0004130_abnormal_muscle_cell0.93628606
87MP0001177_atelectasis0.92019485
88MP0003252_abnormal_bile_duct0.92006670
89MP0001666_abnormal_nutrient_absorption0.91768092
90MP0003566_abnormal_cell_adhesion0.91197506
91MP0010234_abnormal_vibrissa_follicle0.90354086
92MP0010386_abnormal_urinary_bladder0.89549618
93MP0002229_neurodegeneration0.88488821
94MP0005535_abnormal_body_temperature0.87908825
95MP0005551_abnormal_eye_electrophysiolog0.87878294
96MP0005076_abnormal_cell_differentiation0.87830203
97MP0003091_abnormal_cell_migration0.87520565
98MP0003300_gastrointestinal_ulcer0.85565516
99MP0002419_abnormal_innate_immunity0.85325517
100MP0000609_abnormal_liver_physiology0.84429683
101MP0005171_absent_coat_pigmentation0.83903257
102MP0002998_abnormal_bone_remodeling0.83780428
103MP0005464_abnormal_platelet_physiology0.83255332
104MP0009840_abnormal_foam_cell0.81169717
105MP0002254_reproductive_system_inflammat0.78143289
106MP0005310_abnormal_salivary_gland0.75303978
107MP0005164_abnormal_response_to0.74261526
108MP0008875_abnormal_xenobiotic_pharmacok0.74137484
109MP0004883_abnormal_blood_vessel0.72200008
110MP0002152_abnormal_brain_morphology0.68994203
111MP0004381_abnormal_hair_follicle0.68746649
112MP0005387_immune_system_phenotype0.68474652
113MP0001790_abnormal_immune_system0.68474652
114MP0003121_genomic_imprinting0.67230532
115MP0002075_abnormal_coat/hair_pigmentati0.66371067
116MP0001958_emphysema0.65833184
117MP0003436_decreased_susceptibility_to0.65809909
118MP0002069_abnormal_eating/drinking_beha0.65480182
119MP0008872_abnormal_physiological_respon0.64371449
120MP0004742_abnormal_vestibular_system0.64087103
121MP0003453_abnormal_keratinocyte_physiol0.63855309
122MP0001661_extended_life_span0.62661666
123MP0000015_abnormal_ear_pigmentation0.62033060
124MP0005248_abnormal_Harderian_gland0.62024916
125MP0005645_abnormal_hypothalamus_physiol0.61860372
126MP0001835_abnormal_antigen_presentation0.61630088
127MP0003656_abnormal_erythrocyte_physiolo0.61042473
128MP0003191_abnormal_cellular_cholesterol0.60192962
129MP0001756_abnormal_urination0.60166741
130* MP0001905_abnormal_dopamine_level0.55583962
131MP0004947_skin_inflammation0.54379992
132MP0002877_abnormal_melanocyte_morpholog0.54309749
133MP0005000_abnormal_immune_tolerance0.53766146
134MP0001299_abnormal_eye_distance/0.53725363
135MP0003283_abnormal_digestive_organ0.52981233
136MP0004142_abnormal_muscle_tone0.51293692
137MP0003122_maternal_imprinting0.50469765

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.52244445
2Focal motor seizures (HP:0011153)5.50697332
3Complement deficiency (HP:0004431)4.85506012
4Glomerulonephritis (HP:0000099)4.39563048
5Focal seizures (HP:0007359)4.39495383
6Myokymia (HP:0002411)4.14679196
7Supranuclear gaze palsy (HP:0000605)3.97728853
8Increased cerebral lipofuscin (HP:0011813)3.96731879
9Atonic seizures (HP:0010819)3.79787003
10Abnormality of complement system (HP:0005339)3.75258548
11Action tremor (HP:0002345)3.73317311
12Epileptic encephalopathy (HP:0200134)3.69012642
13Visual hallucinations (HP:0002367)3.67008660
14Febrile seizures (HP:0002373)3.65337700
15Systemic lupus erythematosus (HP:0002725)3.64498445
16Absence seizures (HP:0002121)3.35348353
17Progressive cerebellar ataxia (HP:0002073)3.27776240
18Neurofibrillary tangles (HP:0002185)3.22917557
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.19626069
20Joint hemorrhage (HP:0005261)3.19288653
21Generalized tonic-clonic seizures (HP:0002069)3.18707551
22Dialeptic seizures (HP:0011146)3.07916171
23Cerebral inclusion bodies (HP:0100314)3.03800988
24Mutism (HP:0002300)3.01365145
25Abnormality of glycosphingolipid metabolism (HP:0004343)3.00229142
26Abnormality of glycolipid metabolism (HP:0010969)3.00229142
27Abnormality of liposaccharide metabolism (HP:0010968)3.00229142
28Ankle clonus (HP:0011448)2.99556898
29Xanthomatosis (HP:0000991)2.98487679
30Prolonged partial thromboplastin time (HP:0003645)2.95541091
31Hematochezia (HP:0002573)2.85064607
32Mitral stenosis (HP:0001718)2.83820202
33Abnormality of binocular vision (HP:0011514)2.83191440
34Diplopia (HP:0000651)2.83191440
35Recurrent abscess formation (HP:0002722)2.79917702
36Postural instability (HP:0002172)2.75726496
37Recurrent bacterial skin infections (HP:0005406)2.72045420
38Dysdiadochokinesis (HP:0002075)2.68153291
39Abnormality of the common coagulation pathway (HP:0010990)2.68053972
40Impaired vibration sensation in the lower limbs (HP:0002166)2.67840535
41Dysmetria (HP:0001310)2.67496431
42Alacrima (HP:0000522)2.66493086
43Hemiplegia (HP:0002301)2.59300335
44Peripheral hypomyelination (HP:0007182)2.59252057
45Disinhibition (HP:0000734)2.55971568
46Neuronal loss in central nervous system (HP:0002529)2.53805938
47Genetic anticipation (HP:0003743)2.51394252
48Inappropriate behavior (HP:0000719)2.50462854
49Gaze-evoked nystagmus (HP:0000640)2.50124210
50Urinary bladder sphincter dysfunction (HP:0002839)2.49186080
51Drooling (HP:0002307)2.46340265
52Excessive salivation (HP:0003781)2.46340265
53Nephritis (HP:0000123)2.46254943
54Depression (HP:0000716)2.36779778
55Abnormality of aromatic amino acid family metabolism (HP:0004338)2.34024942
56Abnormality of ocular smooth pursuit (HP:0000617)2.33432966
57Broad-based gait (HP:0002136)2.33292504
58Hypercholesterolemia (HP:0003124)2.33078993
59Clumsiness (HP:0002312)2.31597109
60Apathy (HP:0000741)2.30855204
61Purpura (HP:0000979)2.30536435
62Loss of speech (HP:0002371)2.30071896
63Dysmetric saccades (HP:0000641)2.28770927
64Blue irides (HP:0000635)2.26994034
65Intention tremor (HP:0002080)2.26865003
66Hemorrhage of the eye (HP:0011885)2.25019309
67Obstructive sleep apnea (HP:0002870)2.24242451
68Hemiparesis (HP:0001269)2.23660269
69Hypobetalipoproteinemia (HP:0003563)2.23485833
70Abnormal social behavior (HP:0012433)2.21119959
71Impaired social interactions (HP:0000735)2.21119959
72Abnormality of the lower motor neuron (HP:0002366)2.20853714
73Abnormality of monocarboxylic acid metabolism (HP:0010996)2.20610801
74Myocardial infarction (HP:0001658)2.20506353
75Eczematoid dermatitis (HP:0000976)2.20098573
76Absent frontal sinuses (HP:0002688)2.20090390
77Abnormal eating behavior (HP:0100738)2.19976787
78Dysostosis multiplex (HP:0000943)2.19872051
79Truncal ataxia (HP:0002078)2.18861671
80Poor eye contact (HP:0000817)2.17535140
81Impaired smooth pursuit (HP:0007772)2.15034481
82Postural tremor (HP:0002174)2.14491434
83Papilledema (HP:0001085)2.13269574
84Skin nodule (HP:0200036)2.12437704
85Interstitial pulmonary disease (HP:0006530)2.10575183
86Decreased lacrimation (HP:0000633)2.08510067
87Status epilepticus (HP:0002133)2.08133329
88Amyloidosis (HP:0011034)2.07089094
89Epidermoid cyst (HP:0200040)2.04323580
90Upper motor neuron abnormality (HP:0002127)2.03923354
91Diminished motivation (HP:0000745)2.02932565
92Abnormality of polysaccharide metabolism (HP:0011012)2.01706310
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01706310
94Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01706310
95Gingival bleeding (HP:0000225)2.01284990
96Stereotypic behavior (HP:0000733)2.00957958
97Lower limb muscle weakness (HP:0007340)2.00689114
98Scanning speech (HP:0002168)2.00609508
99Bradykinesia (HP:0002067)1.99717696
100Arterial tortuosity (HP:0005116)1.98883139
101Dementia (HP:0000726)1.97765564
102Hyperventilation (HP:0002883)1.97027482
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96277335
104Vertebral compression fractures (HP:0002953)1.95827046
105Abnormality of the periventricular white matter (HP:0002518)1.93040649
106Mediastinal lymphadenopathy (HP:0100721)1.92937740
107Spastic gait (HP:0002064)1.92890315
108Cerebral aneurysm (HP:0004944)1.91517069
109Progressive inability to walk (HP:0002505)1.87956225
110Impaired vibratory sensation (HP:0002495)1.87804581
111Aplasia involving bones of the upper limbs (HP:0009823)1.87268935
112Aplasia of the phalanges of the hand (HP:0009802)1.87268935
113Aplasia involving bones of the extremities (HP:0009825)1.87268935
114Urinary glycosaminoglycan excretion (HP:0003541)1.86559543
115Mucopolysacchariduria (HP:0008155)1.86559543
116Hepatoblastoma (HP:0002884)1.86376216
117Abnormality of macrophages (HP:0004311)1.86077878
118Retinal atrophy (HP:0001105)1.85550318
119Torticollis (HP:0000473)1.85148098
120Anxiety (HP:0000739)1.82183365
121Bronchomalacia (HP:0002780)1.77234261
122Lower limb amyotrophy (HP:0007210)1.77000681
123Akinesia (HP:0002304)1.76089250
124Abnormality of salivation (HP:0100755)1.75485703
125Recurrent gram-negative bacterial infections (HP:0005420)1.73812841
126Clonus (HP:0002169)1.73003700
127Rapidly progressive (HP:0003678)1.72695799
128Supernumerary nipples (HP:0002558)1.71848281
129Axonal loss (HP:0003447)1.71575626
130Menorrhagia (HP:0000132)1.71379485
131Absent speech (HP:0001344)1.71208739
132Colitis (HP:0002583)1.70967473
133Epileptiform EEG discharges (HP:0011182)1.70484660
134Annular pancreas (HP:0001734)1.69816194
135Abnormality of saccadic eye movements (HP:0000570)1.69466755
136Striae distensae (HP:0001065)1.68903723
137Generalized myoclonic seizures (HP:0002123)1.68416148
138Global brain atrophy (HP:0002283)1.65926637
139Onion bulb formation (HP:0003383)1.63906098
140Rigidity (HP:0002063)1.61864016
141Slow saccadic eye movements (HP:0000514)1.61803597
142Broad face (HP:0000283)1.56925191
143Nuclear cataract (HP:0100018)1.56813578
144Flat acetabular roof (HP:0003180)1.56281423
145Hypolipoproteinemia (HP:0010981)1.55996549
146Macroorchidism (HP:0000053)1.55577999
147Personality changes (HP:0000751)1.55120349
148Ocular albinism (HP:0001107)1.54853275
149Asymmetry of the thorax (HP:0001555)1.54618031
150Testicular neoplasm (HP:0010788)1.53676218
151Abnormality of carpal bone ossification (HP:0006257)1.53656530
152Vacuolated lymphocytes (HP:0001922)1.52247324
153Hypoglycemic seizures (HP:0002173)1.51634602
154Vascular calcification (HP:0004934)1.50295631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.87426303
2MAP3K93.66226661
3NTRK33.41869143
4RIPK43.07121616
5DAPK22.68819207
6FGFR42.66185775
7MAP3K42.49548550
8ICK2.44662208
9ERN12.36400935
10MAP3K132.14360667
11KSR22.06799659
12PAK62.01626615
13NTRK11.99761764
14CAMKK11.84094046
15PDGFRA1.77765575
16NTRK21.75812806
17CDK121.66755432
18FES1.64531599
19JAK11.62420111
20MINK11.61089089
21TYK21.55074550
22MAP3K21.53524385
23MAP2K71.52295825
24AKT31.48613829
25BMPR21.43723024
26MAP2K41.37861882
27FGFR21.35062866
28MARK11.34987676
29KSR11.34721154
30SIK11.30879154
31CDC42BPA1.28499667
32TYRO31.28106517
33UHMK11.27441333
34PLK21.27204643
35PRKD31.25630874
36CAMKK21.23443342
37BLK1.20368679
38SIK21.20165576
39EEF2K1.19091813
40SGK21.19037488
41SGK31.18086714
42CDK51.17070248
43FGR1.15257575
44RIPK11.14035913
45MAP3K121.13984583
46DAPK11.13875267
47PRPF4B1.11280520
48PRKCH1.09654528
49STK381.08805984
50TAOK11.07813670
51ALK1.03013683
52GRK51.00283145
53RET1.00109253
54SGK4941.00103413
55SGK2231.00103413
56CASK0.97004575
57CAMK1G0.94021791
58SCYL20.93442274
59MAP3K10.90526968
60NEK60.83534872
61IRAK30.81834625
62PDPK10.81552429
63SMG10.81159182
64MOS0.78004309
65SGK10.76505952
66LMTK20.76331947
67MAPK110.76290647
68PDK10.74801174
69BMX0.73515767
70PRKCG0.72266889
71CAMK10.71598108
72CAMK1D0.70847343
73MAP3K140.70416491
74BRD40.70206220
75SIK30.67803470
76TAOK30.67536284
77WNK10.67026868
78PTK2B0.65581740
79MAPK70.63959787
80CAMK2A0.61369051
81CSF1R0.61191636
82TRIB30.60309745
83PKN20.57265316
84FER0.56881703
85FYN0.56062194
86CSK0.55941451
87PDGFRB0.55754657
88TBK10.55486386
89CDK190.54981942
90MATK0.54268438
91MAP3K70.54144017
92ARAF0.53908236
93JAK20.52047948
94STK110.51368439
95MAP4K10.51148731
96PHKG10.51147643
97PHKG20.51147643
98FGFR30.50196556
99MTOR0.49329802
100PRKAA20.49206739
101TNK20.47413535
102EPHB10.47301345
103NEK90.46821945
104RPS6KB10.46659386
105PRKCZ0.46613761
106ZAP700.46375749
107MAPK100.45932955
108RPS6KA30.45765548
109PRKD20.45572122
110CDK60.45128674
111RPS6KA20.44783652
112LATS20.43648786
113MAP3K60.43442660
114HCK0.42938570
115KIT0.42751971
116CAMK40.40877100
117PRKCE0.40078703
118HIPK20.39551748
119SRC0.39451710
120MAPK130.38423076
121CDK150.38121984
122DYRK1A0.37892005
123TGFBR20.36988893
124ERBB40.36949678
125TNIK0.36896926
126CAMK2B0.36841170
127IRAK20.36645808
128MAPK120.36561702
129DDR20.36443900
130MARK20.35977080
131EGFR0.34943603
132JAK30.34916546

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046102.98653488
2Synaptic vesicle cycle_Homo sapiens_hsa047212.83070107
3Nicotine addiction_Homo sapiens_hsa050332.67150946
4Other glycan degradation_Homo sapiens_hsa005112.53487204
5GABAergic synapse_Homo sapiens_hsa047272.07941109
6Olfactory transduction_Homo sapiens_hsa047402.01511193
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.95266268
8Long-term potentiation_Homo sapiens_hsa047201.92839379
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91063050
10Circadian entrainment_Homo sapiens_hsa047131.90325491
11Morphine addiction_Homo sapiens_hsa050321.87081770
12Glutamatergic synapse_Homo sapiens_hsa047241.86437440
13Nitrogen metabolism_Homo sapiens_hsa009101.66046152
14Salivary secretion_Homo sapiens_hsa049701.65629392
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57620377
16Collecting duct acid secretion_Homo sapiens_hsa049661.56501571
17Amphetamine addiction_Homo sapiens_hsa050311.52288795
18Type II diabetes mellitus_Homo sapiens_hsa049301.50080187
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49314903
20Gastric acid secretion_Homo sapiens_hsa049711.48589001
21Cholinergic synapse_Homo sapiens_hsa047251.48076971
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43560977
23Insulin secretion_Homo sapiens_hsa049111.42782573
24Vitamin B6 metabolism_Homo sapiens_hsa007501.41815737
25Dopaminergic synapse_Homo sapiens_hsa047281.33484610
26GnRH signaling pathway_Homo sapiens_hsa049121.24892388
27Long-term depression_Homo sapiens_hsa047301.24201458
28Renin secretion_Homo sapiens_hsa049241.23356385
29Histidine metabolism_Homo sapiens_hsa003401.22877419
30Lysosome_Homo sapiens_hsa041421.20664182
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20425000
32Oxytocin signaling pathway_Homo sapiens_hsa049211.20299077
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17860535
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16598482
35Cocaine addiction_Homo sapiens_hsa050301.15222475
36Dorso-ventral axis formation_Homo sapiens_hsa043201.12860571
37Rheumatoid arthritis_Homo sapiens_hsa053231.07649791
38ABC transporters_Homo sapiens_hsa020101.06962250
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04546807
40Calcium signaling pathway_Homo sapiens_hsa040201.04497221
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04283347
42Estrogen signaling pathway_Homo sapiens_hsa049151.03465981
43Taste transduction_Homo sapiens_hsa047421.02227630
44Glioma_Homo sapiens_hsa052141.01689337
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00996787
46Serotonergic synapse_Homo sapiens_hsa047261.00573931
47cAMP signaling pathway_Homo sapiens_hsa040240.99757367
48PPAR signaling pathway_Homo sapiens_hsa033200.99051889
49Osteoclast differentiation_Homo sapiens_hsa043800.98801833
50Tuberculosis_Homo sapiens_hsa051520.97731697
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94107560
52African trypanosomiasis_Homo sapiens_hsa051430.93887440
53Non-small cell lung cancer_Homo sapiens_hsa052230.90805738
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88361439
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.87028173
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87023197
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86728437
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86016980
59Vibrio cholerae infection_Homo sapiens_hsa051100.85260902
60Gap junction_Homo sapiens_hsa045400.85093225
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84862045
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.84742631
63Chemokine signaling pathway_Homo sapiens_hsa040620.84139323
64ErbB signaling pathway_Homo sapiens_hsa040120.81832905
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81304736
66Type I diabetes mellitus_Homo sapiens_hsa049400.81256516
67Sphingolipid metabolism_Homo sapiens_hsa006000.80332725
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.80128903
69Phagosome_Homo sapiens_hsa041450.79191227
70Arginine biosynthesis_Homo sapiens_hsa002200.78375739
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77823134
72Fatty acid biosynthesis_Homo sapiens_hsa000610.77666403
73MAPK signaling pathway_Homo sapiens_hsa040100.77082757
74mTOR signaling pathway_Homo sapiens_hsa041500.75952501
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75400522
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.74302023
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74052656
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71895788
79TNF signaling pathway_Homo sapiens_hsa046680.71375721
80Leishmaniasis_Homo sapiens_hsa051400.70618052
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70036268
82Prion diseases_Homo sapiens_hsa050200.67588131
83Choline metabolism in cancer_Homo sapiens_hsa052310.67270554
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66051605
85Bile secretion_Homo sapiens_hsa049760.66042766
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65276011
87B cell receptor signaling pathway_Homo sapiens_hsa046620.65180575
88Chronic myeloid leukemia_Homo sapiens_hsa052200.64977791
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.64718593
90Salmonella infection_Homo sapiens_hsa051320.64139436
91Inositol phosphate metabolism_Homo sapiens_hsa005620.64087197
92Mineral absorption_Homo sapiens_hsa049780.64053489
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63643587
94Renal cell carcinoma_Homo sapiens_hsa052110.62810374
95Insulin signaling pathway_Homo sapiens_hsa049100.62113508
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.61676517
97VEGF signaling pathway_Homo sapiens_hsa043700.61229340
98Endometrial cancer_Homo sapiens_hsa052130.60140630
99Prolactin signaling pathway_Homo sapiens_hsa049170.58782147
100Pancreatic secretion_Homo sapiens_hsa049720.58461674
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58199866
102Ovarian steroidogenesis_Homo sapiens_hsa049130.57978353
103Axon guidance_Homo sapiens_hsa043600.57189024
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57095549
105Glucagon signaling pathway_Homo sapiens_hsa049220.56957086
106Insulin resistance_Homo sapiens_hsa049310.56838011
107Pertussis_Homo sapiens_hsa051330.56538930
108Rap1 signaling pathway_Homo sapiens_hsa040150.56411721
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.56338444
110Dilated cardiomyopathy_Homo sapiens_hsa054140.56206763
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55791395
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55677138
113Lysine degradation_Homo sapiens_hsa003100.55338917
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53148288
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53127402
116Thyroid hormone synthesis_Homo sapiens_hsa049180.53042160
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52551773
118Endocytosis_Homo sapiens_hsa041440.52181289
119Tyrosine metabolism_Homo sapiens_hsa003500.51406858
120Melanogenesis_Homo sapiens_hsa049160.51401116
121Circadian rhythm_Homo sapiens_hsa047100.51136759
122Acute myeloid leukemia_Homo sapiens_hsa052210.48620305
123Phenylalanine metabolism_Homo sapiens_hsa003600.48253704
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48064649
125Fatty acid degradation_Homo sapiens_hsa000710.47984571
126Ras signaling pathway_Homo sapiens_hsa040140.47603744
127Amoebiasis_Homo sapiens_hsa051460.45255473
128Staphylococcus aureus infection_Homo sapiens_hsa051500.44974868
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.44709721
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44333899

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