Rank | Gene Set | Z-score |
---|---|---|
1 | angiotensin maturation (GO:0002003) | 6.62236857 |
2 | lysine metabolic process (GO:0006553) | 6.36677410 |
3 | lysine catabolic process (GO:0006554) | 6.36677410 |
4 | drug transmembrane transport (GO:0006855) | 6.10148432 |
5 | epoxygenase P450 pathway (GO:0019373) | 6.05413956 |
6 | regulation of guanylate cyclase activity (GO:0031282) | 6.02372281 |
7 | homocysteine metabolic process (GO:0050667) | 5.72220713 |
8 | aminoglycoside antibiotic metabolic process (GO:0030647) | 5.61280062 |
9 | urate metabolic process (GO:0046415) | 5.56760458 |
10 | diol metabolic process (GO:0034311) | 5.39802037 |
11 | drug transport (GO:0015893) | 5.33572612 |
12 | regulation of protein glycosylation (GO:0060049) | 5.08501008 |
13 | organic cation transport (GO:0015695) | 5.05431709 |
14 | positive regulation of glycoprotein biosynthetic process (GO:0010560) | 5.02255051 |
15 | drug metabolic process (GO:0017144) | 5.01630486 |
16 | sphingoid metabolic process (GO:0046519) | 4.95734452 |
17 | regulation of bile acid biosynthetic process (GO:0070857) | 4.91358002 |
18 | cytidine metabolic process (GO:0046087) | 4.90932038 |
19 | cytidine catabolic process (GO:0006216) | 4.90932038 |
20 | cytidine deamination (GO:0009972) | 4.90932038 |
21 | sphingosine metabolic process (GO:0006670) | 4.83593165 |
22 | positive regulation of guanylate cyclase activity (GO:0031284) | 4.76920577 |
23 | vitamin D metabolic process (GO:0042359) | 4.66196085 |
24 | cysteine metabolic process (GO:0006534) | 4.61650015 |
25 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 4.52680630 |
26 | indole-containing compound catabolic process (GO:0042436) | 4.47831460 |
27 | indolalkylamine catabolic process (GO:0046218) | 4.47831460 |
28 | tryptophan catabolic process (GO:0006569) | 4.47831460 |
29 | renal absorption (GO:0070293) | 4.46031955 |
30 | excretion (GO:0007588) | 4.42512784 |
31 | diacylglycerol metabolic process (GO:0046339) | 4.41572611 |
32 | transepithelial transport (GO:0070633) | 4.39967938 |
33 | fat-soluble vitamin biosynthetic process (GO:0042362) | 4.36941474 |
34 | regulation of triglyceride catabolic process (GO:0010896) | 4.28277461 |
35 | galactose catabolic process (GO:0019388) | 4.25357397 |
36 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338) | 4.24365716 |
37 | sulfate transmembrane transport (GO:1902358) | 4.22342780 |
38 | short-chain fatty acid metabolic process (GO:0046459) | 4.19623110 |
39 | positive regulation of glycoprotein metabolic process (GO:1903020) | 4.18691929 |
40 | intestinal absorption (GO:0050892) | 4.15833983 |
41 | quinone biosynthetic process (GO:1901663) | 4.12511260 |
42 | tryptophan metabolic process (GO:0006568) | 4.11954739 |
43 | nonribosomal peptide biosynthetic process (GO:0019184) | 4.09250214 |
44 | response to phenylpropanoid (GO:0080184) | 4.09051452 |
45 | aspartate family amino acid catabolic process (GO:0009068) | 4.05784422 |
46 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.04820133 |
47 | L-phenylalanine metabolic process (GO:0006558) | 4.03678396 |
48 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 4.03678396 |
49 | aromatic amino acid family catabolic process (GO:0009074) | 4.00546704 |
50 | drug catabolic process (GO:0042737) | 3.91764844 |
51 | flavonoid metabolic process (GO:0009812) | 3.91500968 |
52 | citrulline biosynthetic process (GO:0019240) | 3.88750095 |
53 | phosphate ion transport (GO:0006817) | 3.86844223 |
54 | cellular ketone body metabolic process (GO:0046950) | 3.86485634 |
55 | exogenous drug catabolic process (GO:0042738) | 3.85492235 |
56 | alkaloid metabolic process (GO:0009820) | 3.84900158 |
57 | kynurenine metabolic process (GO:0070189) | 3.83695413 |
58 | L-fucose catabolic process (GO:0042355) | 3.83368616 |
59 | fucose catabolic process (GO:0019317) | 3.83368616 |
60 | L-fucose metabolic process (GO:0042354) | 3.83368616 |
61 | response to parathyroid hormone (GO:0071107) | 3.81279720 |
62 | glutathione biosynthetic process (GO:0006750) | 3.80701361 |
63 | regulation of cGMP biosynthetic process (GO:0030826) | 3.79057400 |
64 | phosphate ion homeostasis (GO:0055062) | 3.78481960 |
65 | trivalent inorganic anion homeostasis (GO:0072506) | 3.78481960 |
66 | positive regulation of digestive system process (GO:0060456) | 3.76609883 |
67 | 2-oxoglutarate metabolic process (GO:0006103) | 3.76356615 |
68 | artery smooth muscle contraction (GO:0014824) | 3.74634483 |
69 | auditory receptor cell differentiation (GO:0042491) | 3.72815227 |
70 | fructose metabolic process (GO:0006000) | 3.69902326 |
71 | biotin metabolic process (GO:0006768) | 3.68760350 |
72 | vitamin transport (GO:0051180) | 3.66567284 |
73 | cobalamin metabolic process (GO:0009235) | 3.66534614 |
74 | superoxide anion generation (GO:0042554) | 3.63390675 |
75 | polyol transport (GO:0015791) | 3.59474847 |
76 | L-phenylalanine catabolic process (GO:0006559) | 3.59138414 |
77 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 3.59138414 |
78 | phosphate ion transmembrane transport (GO:0035435) | 3.57965701 |
79 | cellular glucuronidation (GO:0052695) | 3.55958665 |
80 | hormone catabolic process (GO:0042447) | 3.55919593 |
81 | lipoprotein transport (GO:0042953) | 3.55748639 |
82 | vitamin transmembrane transport (GO:0035461) | 3.54494327 |
83 | cellular response to vitamin D (GO:0071305) | 3.53439896 |
84 | negative regulation of keratinocyte proliferation (GO:0010839) | 3.52158371 |
85 | regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044) | 3.50265285 |
86 | endocrine process (GO:0050886) | 3.50265285 |
87 | regulation of systemic arterial blood pressure by hormone (GO:0001990) | 3.50265285 |
88 | bile acid and bile salt transport (GO:0015721) | 3.49379462 |
89 | glyoxylate metabolic process (GO:0046487) | 3.49028689 |
90 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.48871129 |
91 | sulfate transport (GO:0008272) | 3.47451150 |
92 | vitamin biosynthetic process (GO:0009110) | 3.46779705 |
93 | glucuronate metabolic process (GO:0019585) | 3.45954464 |
94 | uronic acid metabolic process (GO:0006063) | 3.45954464 |
95 | base-excision repair, AP site formation (GO:0006285) | 3.42291858 |
96 | amino-acid betaine metabolic process (GO:0006577) | 3.39553738 |
97 | peptide hormone processing (GO:0016486) | 3.37419568 |
98 | sulfur compound transport (GO:0072348) | 3.33975159 |
99 | regulation of cGMP metabolic process (GO:0030823) | 3.33189219 |
100 | glycerol metabolic process (GO:0006071) | 3.27069914 |
101 | cellular carbohydrate catabolic process (GO:0044275) | 3.25846294 |
102 | adhesion of symbiont to host cell (GO:0044650) | 3.25465435 |
103 | virion attachment to host cell (GO:0019062) | 3.25465435 |
104 | glycosylceramide metabolic process (GO:0006677) | 3.25125163 |
105 | tonic smooth muscle contraction (GO:0014820) | 3.24523700 |
106 | cellular modified amino acid catabolic process (GO:0042219) | 3.20665418 |
107 | arginine metabolic process (GO:0006525) | 3.20632722 |
108 | ketone body metabolic process (GO:1902224) | 3.20464995 |
109 | heme transport (GO:0015886) | 3.20445496 |
110 | response to mercury ion (GO:0046689) | 3.20118878 |
111 | xenobiotic catabolic process (GO:0042178) | 3.18280028 |
112 | interferon-gamma secretion (GO:0072643) | 3.18036290 |
113 | indole-containing compound metabolic process (GO:0042430) | 3.16877212 |
114 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.16815728 |
115 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.13707481 |
116 | modified amino acid transport (GO:0072337) | 3.13664811 |
117 | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc | 3.13344861 |
118 | digestion (GO:0007586) | 3.12975340 |
119 | carnitine metabolic process (GO:0009437) | 3.12696919 |
120 | regulation of systemic arterial blood pressure (GO:0003073) | 3.12358071 |
121 | ribosomal large subunit biogenesis (GO:0042273) | 3.11702406 |
122 | proline transport (GO:0015824) | 3.10773382 |
123 | inositol phosphate-mediated signaling (GO:0048016) | 3.09751083 |
124 | L-ascorbic acid metabolic process (GO:0019852) | 3.07360975 |
125 | fat-soluble vitamin metabolic process (GO:0006775) | 3.06988026 |
126 | regulation of hydrogen peroxide metabolic process (GO:0010310) | 3.06175797 |
127 | glycine transport (GO:0015816) | 3.06152117 |
128 | serine family amino acid catabolic process (GO:0009071) | 3.05725869 |
129 | NADH metabolic process (GO:0006734) | 3.04891687 |
130 | branched-chain amino acid metabolic process (GO:0009081) | 3.04541593 |
131 | 3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427) | 3.04434270 |
132 | purine ribonucleoside bisphosphate metabolic process (GO:0034035) | 3.04434270 |
133 | amino-acid betaine transport (GO:0015838) | 3.02824302 |
134 | carnitine transport (GO:0015879) | 3.02824302 |
135 | proline metabolic process (GO:0006560) | 3.02435045 |
136 | quinone metabolic process (GO:1901661) | 3.01675916 |
137 | aromatic amino acid family metabolic process (GO:0009072) | 3.00405543 |
138 | acetyl-CoA metabolic process (GO:0006084) | 3.00322357 |
139 | peptide biosynthetic process (GO:0043043) | 3.00243769 |
140 | positive regulation of uterine smooth muscle contraction (GO:0070474) | 2.99255062 |
141 | surfactant homeostasis (GO:0043129) | 2.99155117 |
142 | fatty acid beta-oxidation (GO:0006635) | 2.98838436 |
143 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 2.98707767 |
144 | amine catabolic process (GO:0009310) | 2.97578496 |
145 | cellular biogenic amine catabolic process (GO:0042402) | 2.97578496 |
146 | oxaloacetate metabolic process (GO:0006107) | 2.95371116 |
147 | phosphatidylserine acyl-chain remodeling (GO:0036150) | 2.94681240 |
148 | positive regulation of cGMP biosynthetic process (GO:0030828) | 2.89986088 |
149 | indolalkylamine metabolic process (GO:0006586) | 2.88548404 |
150 | coenzyme catabolic process (GO:0009109) | 2.87801256 |
151 | fatty acid oxidation (GO:0019395) | 2.87410194 |
152 | regulation of cellular extravasation (GO:0002691) | 2.87065501 |
153 | very-low-density lipoprotein particle assembly (GO:0034379) | 2.86678492 |
154 | glutathione derivative biosynthetic process (GO:1901687) | 2.85472191 |
155 | glutathione derivative metabolic process (GO:1901685) | 2.85472191 |
156 | negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804) | 2.85224910 |
157 | peptide catabolic process (GO:0043171) | 2.85062217 |
158 | nucleobase catabolic process (GO:0046113) | 2.84778463 |
159 | ether lipid metabolic process (GO:0046485) | 2.84453471 |
160 | cellular response to gamma radiation (GO:0071480) | 2.84340038 |
161 | high-density lipoprotein particle remodeling (GO:0034375) | 2.83416994 |
162 | omega-hydroxylase P450 pathway (GO:0097267) | 2.80479021 |
163 | behavioral response to nicotine (GO:0035095) | 2.80366938 |
164 | renal system process involved in regulation of blood volume (GO:0001977) | 2.79694788 |
165 | receptor guanylyl cyclase signaling pathway (GO:0007168) | 2.77674325 |
166 | response to pheromone (GO:0019236) | 2.76576199 |
167 | fat-soluble vitamin catabolic process (GO:0042363) | 2.75510901 |
168 | vitamin catabolic process (GO:0009111) | 2.75510901 |
169 | photoreceptor cell maintenance (GO:0045494) | 2.75080788 |
170 | alditol metabolic process (GO:0019400) | 2.74018353 |
171 | bile acid metabolic process (GO:0008206) | 2.72063982 |
172 | phenol-containing compound catabolic process (GO:0019336) | 2.71931468 |
173 | positive regulation of fatty acid transport (GO:2000193) | 2.70101532 |
174 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 2.69216785 |
175 | phenylpropanoid metabolic process (GO:0009698) | 2.68544968 |
176 | phosphatidylinositol acyl-chain remodeling (GO:0036149) | 2.67504319 |
177 | positive regulation of icosanoid secretion (GO:0032305) | 2.66716524 |
178 | quaternary ammonium group transport (GO:0015697) | 2.64874902 |
179 | regulation of lipoprotein metabolic process (GO:0050746) | 2.63726047 |
180 | iron coordination entity transport (GO:1901678) | 2.63015690 |
181 | response to nitrosative stress (GO:0051409) | 2.59543439 |
182 | plasma lipoprotein particle assembly (GO:0034377) | 2.58768970 |
183 | phosphatidylcholine acyl-chain remodeling (GO:0036151) | 2.58404454 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 5.71890528 |
2 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 3.57221857 |
3 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.31897379 |
4 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 3.04784401 |
5 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.69485482 |
6 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.65138171 |
7 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.64664548 |
8 | VDR_22108803_ChIP-Seq_LS180_Human | 2.60919429 |
9 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.56362723 |
10 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 2.54523199 |
11 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.51256686 |
12 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 2.42422826 |
13 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 2.25507097 |
14 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 2.24585948 |
15 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.23612955 |
16 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 2.19563983 |
17 | * NFE2_27457419_Chip-Seq_LIVER_Mouse | 2.18031596 |
18 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 2.05230885 |
19 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.04303081 |
20 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.01207987 |
21 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.98209386 |
22 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.94678577 |
23 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.92697874 |
24 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.90299631 |
25 | * EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.89198562 |
26 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.88815003 |
27 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.82038697 |
28 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.81587965 |
29 | STAT1_17558387_ChIP-Seq_HELA_Human | 1.80481007 |
30 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.75060293 |
31 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.71052373 |
32 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.69085374 |
33 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.65089069 |
34 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.60997722 |
35 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.59182446 |
36 | * P53_22387025_ChIP-Seq_ESCs_Mouse | 1.56750573 |
37 | * CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.56303939 |
38 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 1.55481451 |
39 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.52161517 |
40 | * EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.51504633 |
41 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.51419637 |
42 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.50016348 |
43 | * SOX2_20726797_ChIP-Seq_SW620_Human | 1.49453512 |
44 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.49269306 |
45 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 1.49037859 |
46 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.48571676 |
47 | GATA1_22025678_ChIP-Seq_K562_Human | 1.48479402 |
48 | * NMYC_18555785_Chip-Seq_ESCs_Mouse | 1.48327252 |
49 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.47788915 |
50 | * ZFX_18555785_Chip-Seq_ESCs_Mouse | 1.47111946 |
51 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.47110568 |
52 | * OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.45928141 |
53 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.45295330 |
54 | ESRRB_18555785_Chip-Seq_ESCs_Mouse | 1.44974573 |
55 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.44300808 |
56 | CTCF_18555785_Chip-Seq_ESCs_Mouse | 1.44000452 |
57 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.42202096 |
58 | * RUNX1_27457419_Chip-Seq_LIVER_Mouse | 1.41829048 |
59 | P300_19829295_ChIP-Seq_ESCs_Human | 1.41721495 |
60 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.41390548 |
61 | * CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.41061561 |
62 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.41012851 |
63 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 1.39940125 |
64 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.39627042 |
65 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.38197101 |
66 | * SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.37333090 |
67 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.37095590 |
68 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.36986610 |
69 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.36782299 |
70 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.36290325 |
71 | * MYC_19829295_ChIP-Seq_ESCs_Human | 1.35005764 |
72 | * E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.34994251 |
73 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.31913015 |
74 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.31561088 |
75 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.31213530 |
76 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.31213530 |
77 | * OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.31086198 |
78 | GATA6_25053715_ChIP-Seq_YYC3_Human | 1.30964087 |
79 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.30824886 |
80 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.30714490 |
81 | AR_20517297_ChIP-Seq_VCAP_Human | 1.27377024 |
82 | * EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.27328598 |
83 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.27144493 |
84 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.26668356 |
85 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.26605792 |
86 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.26250450 |
87 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.25615839 |
88 | * PU1_27457419_Chip-Seq_LIVER_Mouse | 1.24487490 |
89 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.24183052 |
90 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.23765473 |
91 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.23168719 |
92 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.23168719 |
93 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.22267395 |
94 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.21891683 |
95 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.21402437 |
96 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.21402437 |
97 | STAT3_23295773_ChIP-Seq_U87_Human | 1.18875186 |
98 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.18819935 |
99 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.18604643 |
100 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.18172418 |
101 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.17506715 |
102 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.16987995 |
103 | NCOR_22424771_ChIP-Seq_293T_Human | 1.16125233 |
104 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.15908099 |
105 | * TAF2_19829295_ChIP-Seq_ESCs_Human | 1.15530465 |
106 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.15458668 |
107 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.13431734 |
108 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12800489 |
109 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.12388927 |
110 | NFYA_21822215_ChIP-Seq_K562_Human | 1.12100875 |
111 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.11746656 |
112 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.11056468 |
113 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.09225819 |
114 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.07583894 |
115 | TCF4_23295773_ChIP-Seq_U87_Human | 1.07290662 |
116 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.06132147 |
117 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 1.06043053 |
118 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.05121506 |
119 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.04868193 |
120 | KDM2B_26808549_Chip-Seq_REH_Human | 1.04231480 |
121 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.03958071 |
122 | FUS_26573619_Chip-Seq_HEK293_Human | 1.03459976 |
123 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.02692264 |
124 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.02582180 |
125 | AR_25329375_ChIP-Seq_VCAP_Human | 1.02373796 |
126 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.02130433 |
127 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.01654689 |
128 | ERA_21632823_ChIP-Seq_H3396_Human | 1.01261667 |
129 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.00501315 |
130 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.99859340 |
131 | RXR_22108803_ChIP-Seq_LS180_Human | 0.99833995 |
132 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.99658605 |
133 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.99625925 |
134 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.99124586 |
135 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.99088146 |
136 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.98386412 |
137 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.98334402 |
138 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.98133397 |
139 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.98092613 |
140 | * P53_21459846_ChIP-Seq_SAOS-2_Human | 0.98074382 |
141 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.96235622 |
142 | CBP_21632823_ChIP-Seq_H3396_Human | 0.95194317 |
143 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.94900874 |
144 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.94850388 |
145 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.94228472 |
146 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.94066074 |
147 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.93741117 |
148 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.93652368 |
149 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.93535581 |
150 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.93412938 |
151 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.93404108 |
152 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.92902101 |
153 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.92685038 |
154 | KLF5_25053715_ChIP-Seq_YYC3_Human | 0.92252273 |
155 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.92163789 |
156 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 0.91481512 |
157 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.90696478 |
158 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.90242383 |
159 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.89521951 |
160 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.88386826 |
161 | CJUN_26792858_Chip-Seq_BT549_Human | 0.88370581 |
162 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 0.87173570 |
163 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 0.87171028 |
164 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.87144561 |
165 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.86917175 |
166 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.85488079 |
167 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.85007988 |
168 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.84723437 |
169 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 0.84098272 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005360_urolithiasis | 6.60301496 |
2 | MP0002138_abnormal_hepatobiliary_system | 5.56585685 |
3 | MP0004019_abnormal_vitamin_homeostasis | 4.60790539 |
4 | MP0008004_abnormal_stomach_pH | 4.60585934 |
5 | MP0004043_abnormal_pH_regulation | 3.79443154 |
6 | MP0002139_abnormal_hepatobiliary_system | 3.35589864 |
7 | MP0005365_abnormal_bile_salt | 3.06083428 |
8 | MP0003252_abnormal_bile_duct | 3.02129697 |
9 | MP0005085_abnormal_gallbladder_physiolo | 2.94948335 |
10 | MP0005451_abnormal_body_composition | 2.94669621 |
11 | MP0005332_abnormal_amino_acid | 2.92990645 |
12 | MP0003195_calcinosis | 2.81760764 |
13 | MP0003011_delayed_dark_adaptation | 2.62716430 |
14 | MP0009643_abnormal_urine_homeostasis | 2.57967664 |
15 | MP0003183_abnormal_peptide_metabolism | 2.52581841 |
16 | MP0003718_maternal_effect | 2.52340047 |
17 | MP0001765_abnormal_ion_homeostasis | 2.41466980 |
18 | MP0004264_abnormal_extraembryonic_tissu | 2.33339838 |
19 | MP0009840_abnormal_foam_cell | 2.24152276 |
20 | MP0001756_abnormal_urination | 2.20634044 |
21 | MP0000579_abnormal_nail_morphology | 2.20107215 |
22 | MP0003315_abnormal_perineum_morphology | 2.14397121 |
23 | MP0003646_muscle_fatigue | 2.13548654 |
24 | MP0002928_abnormal_bile_duct | 2.11640816 |
25 | MP0005636_abnormal_mineral_homeostasis | 2.10971746 |
26 | MP0005670_abnormal_white_adipose | 2.09289790 |
27 | MP0008875_abnormal_xenobiotic_pharmacok | 1.99359127 |
28 | MP0002136_abnormal_kidney_physiology | 1.93185223 |
29 | MP0001663_abnormal_digestive_system | 1.86810872 |
30 | MP0000538_abnormal_urinary_bladder | 1.85525500 |
31 | MP0009379_abnormal_foot_pigmentation | 1.73176191 |
32 | MP0000613_abnormal_salivary_gland | 1.70892800 |
33 | MP0010234_abnormal_vibrissa_follicle | 1.66371669 |
34 | MP0003300_gastrointestinal_ulcer | 1.63707834 |
35 | MP0005551_abnormal_eye_electrophysiolog | 1.62932479 |
36 | MP0003283_abnormal_digestive_organ | 1.61955312 |
37 | MP0005381_digestive/alimentary_phenotyp | 1.61917263 |
38 | MP0001666_abnormal_nutrient_absorption | 1.60387744 |
39 | MP0001501_abnormal_sleep_pattern | 1.49889465 |
40 | MP0002876_abnormal_thyroid_physiology | 1.49411404 |
41 | MP0002736_abnormal_nociception_after | 1.48948643 |
42 | MP0001986_abnormal_taste_sensitivity | 1.46749294 |
43 | MP0001873_stomach_inflammation | 1.46360081 |
44 | MP0005083_abnormal_biliary_tract | 1.45281017 |
45 | MP0000462_abnormal_digestive_system | 1.42278443 |
46 | MP0003787_abnormal_imprinting | 1.41602570 |
47 | MP0001348_abnormal_lacrimal_gland | 1.37578988 |
48 | MP0008872_abnormal_physiological_respon | 1.29441866 |
49 | MP0000015_abnormal_ear_pigmentation | 1.28916638 |
50 | MP0000427_abnormal_hair_cycle | 1.27371987 |
51 | MP0005174_abnormal_tail_pigmentation | 1.26808893 |
52 | MP0003866_abnormal_defecation | 1.26409344 |
53 | MP0001346_abnormal_lacrimal_gland | 1.26165614 |
54 | MP0009697_abnormal_copulation | 1.24230083 |
55 | MP0005448_abnormal_energy_balance | 1.23960032 |
56 | MP0001485_abnormal_pinna_reflex | 1.19552589 |
57 | MP0005395_other_phenotype | 1.17082406 |
58 | MP0005646_abnormal_pituitary_gland | 1.16397150 |
59 | MP0004484_altered_response_of | 1.15322726 |
60 | MP0005220_abnormal_exocrine_pancreas | 1.12980746 |
61 | MP0001664_abnormal_digestion | 1.12674383 |
62 | MP0002098_abnormal_vibrissa_morphology | 1.12544803 |
63 | MP0006036_abnormal_mitochondrial_physio | 1.11961826 |
64 | MP0001764_abnormal_homeostasis | 1.11769680 |
65 | MP0000013_abnormal_adipose_tissue | 1.10611284 |
66 | MP0004924_abnormal_behavior | 1.07369724 |
67 | MP0005386_behavior/neurological_phenoty | 1.07369724 |
68 | MP0008775_abnormal_heart_ventricle | 1.05500442 |
69 | MP0002796_impaired_skin_barrier | 1.00865438 |
70 | MP0006082_CNS_inflammation | 1.00452866 |
71 | MP0000372_irregular_coat_pigmentation | 0.99517639 |
72 | MP0010329_abnormal_lipoprotein_level | 0.98604006 |
73 | MP0002638_abnormal_pupillary_reflex | 0.97817851 |
74 | MP0010155_abnormal_intestine_physiology | 0.96157980 |
75 | MP0004142_abnormal_muscle_tone | 0.93447872 |
76 | MP0010386_abnormal_urinary_bladder | 0.93390954 |
77 | MP0000490_abnormal_crypts_of | 0.92273538 |
78 | MP0002102_abnormal_ear_morphology | 0.89971168 |
79 | MP0002653_abnormal_ependyma_morphology | 0.89408727 |
80 | MP0002735_abnormal_chemical_nociception | 0.89041437 |
81 | MP0005253_abnormal_eye_physiology | 0.88204384 |
82 | MP0001968_abnormal_touch/_nociception | 0.87621315 |
83 | MP0004885_abnormal_endolymph | 0.87116435 |
84 | MP0005084_abnormal_gallbladder_morpholo | 0.86791069 |
85 | MP0001529_abnormal_vocalization | 0.86647482 |
86 | MP0000566_synostosis | 0.84754478 |
87 | MP0005501_abnormal_skin_physiology | 0.84616594 |
88 | MP0001188_hyperpigmentation | 0.82033570 |
89 | MP0002971_abnormal_brown_adipose | 0.81859764 |
90 | MP0005408_hypopigmentation | 0.80957051 |
91 | MP0004147_increased_porphyrin_level | 0.79911390 |
92 | MP0003941_abnormal_skin_development | 0.78922293 |
93 | MP0005410_abnormal_fertilization | 0.78528497 |
94 | MP0005367_renal/urinary_system_phenotyp | 0.77933376 |
95 | MP0000516_abnormal_urinary_system | 0.77933376 |
96 | MP0005645_abnormal_hypothalamus_physiol | 0.77440411 |
97 | MP0003879_abnormal_hair_cell | 0.77291256 |
98 | MP0002163_abnormal_gland_morphology | 0.76723697 |
99 | MP0003868_abnormal_feces_composition | 0.76627227 |
100 | MP0006276_abnormal_autonomic_nervous | 0.75664729 |
101 | MP0002069_abnormal_eating/drinking_beha | 0.74641868 |
102 | MP0000230_abnormal_systemic_arterial | 0.73693427 |
103 | MP0001119_abnormal_female_reproductive | 0.72734775 |
104 | MP0008469_abnormal_protein_level | 0.71948314 |
105 | MP0005257_abnormal_intraocular_pressure | 0.71869983 |
106 | MP0002078_abnormal_glucose_homeostasis | 0.71355792 |
107 | MP0003186_abnormal_redox_activity | 0.71062303 |
108 | MP0002168_other_aberrant_phenotype | 0.70773299 |
109 | MP0009764_decreased_sensitivity_to | 0.70149909 |
110 | MP0001905_abnormal_dopamine_level | 0.69536220 |
111 | MP0000762_abnormal_tongue_morphology | 0.69506298 |
112 | MP0001845_abnormal_inflammatory_respons | 0.69487809 |
113 | MP0000609_abnormal_liver_physiology | 0.69144763 |
114 | MP0002933_joint_inflammation | 0.68977554 |
115 | MP0009115_abnormal_fat_cell | 0.68807957 |
116 | MP0005377_hearing/vestibular/ear_phenot | 0.66529876 |
117 | MP0003878_abnormal_ear_physiology | 0.66529876 |
118 | MP0002160_abnormal_reproductive_system | 0.66493459 |
119 | MP0001970_abnormal_pain_threshold | 0.65951506 |
120 | MP0001191_abnormal_skin_condition | 0.65705305 |
121 | MP0003453_abnormal_keratinocyte_physiol | 0.65546659 |
122 | MP0002837_dystrophic_cardiac_calcinosis | 0.64862240 |
123 | MP0002148_abnormal_hypersensitivity_rea | 0.64014940 |
124 | MP0003953_abnormal_hormone_level | 0.63978244 |
125 | MP0001958_emphysema | 0.63441204 |
126 | MP0010771_integument_phenotype | 0.61411945 |
127 | MP0002896_abnormal_bone_mineralization | 0.59353854 |
128 | MP0005075_abnormal_melanosome_morpholog | 0.58984866 |
129 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.58535615 |
130 | MP0002557_abnormal_social/conspecific_i | 0.57911253 |
131 | MP0001324_abnormal_eye_pigmentation | 0.57863035 |
132 | MP0000470_abnormal_stomach_morphology | 0.57642945 |
133 | MP0009785_altered_susceptibility_to | 0.57495583 |
134 | MP0000026_abnormal_inner_ear | 0.57187987 |
135 | MP0000751_myopathy | 0.57179772 |
136 | MP0003191_abnormal_cellular_cholesterol | 0.56070364 |
137 | MP0002272_abnormal_nervous_system | 0.55572223 |
138 | MP0002118_abnormal_lipid_homeostasis | 0.52366475 |
139 | MP0001944_abnormal_pancreas_morphology | 0.51617568 |
140 | MP0005165_increased_susceptibility_to | 0.51288424 |
141 | MP0005319_abnormal_enzyme/_coenzyme | 0.50737681 |
142 | MP0003693_abnormal_embryo_hatching | 0.50656325 |
143 | MP0009642_abnormal_blood_homeostasis | 0.50505922 |
144 | MP0002132_abnormal_respiratory_system | 0.49704583 |
145 | MP0002135_abnormal_kidney_morphology | 0.49581658 |
146 | MP0000477_abnormal_intestine_morphology | 0.48097815 |
147 | MP0008961_abnormal_basal_metabolism | 0.47889256 |
148 | MP0005535_abnormal_body_temperature | 0.47428186 |
149 | MP0002089_abnormal_postnatal_growth/wei | 0.46049800 |
150 | MP0003699_abnormal_female_reproductive | 0.45815460 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ventricular fibrillation (HP:0001663) | 6.09732548 |
2 | Metabolic alkalosis (HP:0200114) | 5.34210948 |
3 | Hyperactive renin-angiotensin system (HP:0000841) | 4.97146333 |
4 | Abnormality of chloride homeostasis (HP:0011422) | 4.90993737 |
5 | Polyuria (HP:0000103) | 4.80239422 |
6 | Gout (HP:0001997) | 4.73643636 |
7 | Hypomagnesemia (HP:0002917) | 4.71806546 |
8 | Abnormal urine output (HP:0012590) | 4.61754831 |
9 | Hypokalemic alkalosis (HP:0001949) | 4.58652726 |
10 | Increased circulating renin level (HP:0000848) | 4.51548219 |
11 | Proximal tubulopathy (HP:0000114) | 4.49701684 |
12 | Abnormality of renal excretion (HP:0011036) | 4.40644938 |
13 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.39298603 |
14 | Increased purine levels (HP:0004368) | 4.29073091 |
15 | Hyperuricemia (HP:0002149) | 4.29073091 |
16 | Hyperglycinuria (HP:0003108) | 4.21757859 |
17 | Tetany (HP:0001281) | 3.95445244 |
18 | Abnormality of magnesium homeostasis (HP:0004921) | 3.94390975 |
19 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.84497523 |
20 | Abnormality of glycine metabolism (HP:0010895) | 3.84497523 |
21 | Abnormality of purine metabolism (HP:0004352) | 3.62033829 |
22 | Polydipsia (HP:0001959) | 3.49748315 |
23 | Abnormal drinking behavior (HP:0030082) | 3.49748315 |
24 | Reticulocytopenia (HP:0001896) | 3.46700479 |
25 | Abnormal hemoglobin (HP:0011902) | 3.45327780 |
26 | Ketoacidosis (HP:0001993) | 3.45134114 |
27 | Chronic diarrhea (HP:0002028) | 3.41596400 |
28 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 3.32602725 |
29 | Confusion (HP:0001289) | 3.32337641 |
30 | Potter facies (HP:0002009) | 3.29415921 |
31 | Facial shape deformation (HP:0011334) | 3.29415921 |
32 | Decreased circulating renin level (HP:0003351) | 3.27086716 |
33 | Congenital sensorineural hearing impairment (HP:0008527) | 3.25118922 |
34 | Hyperglycinemia (HP:0002154) | 3.24393843 |
35 | Alkalosis (HP:0001948) | 3.22887492 |
36 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 3.20501904 |
37 | Congenital stationary night blindness (HP:0007642) | 3.20103413 |
38 | Hyperaldosteronism (HP:0000859) | 3.17165074 |
39 | Abnormality of nucleobase metabolism (HP:0010932) | 3.12486064 |
40 | Abnormality of vitamin B metabolism (HP:0004340) | 3.08372529 |
41 | Glycosuria (HP:0003076) | 3.07001520 |
42 | Abnormality of urine glucose concentration (HP:0011016) | 3.07001520 |
43 | Hypercalciuria (HP:0002150) | 3.06984966 |
44 | Delayed epiphyseal ossification (HP:0002663) | 3.03027811 |
45 | Dehydration (HP:0001944) | 2.95859872 |
46 | Hypobetalipoproteinemia (HP:0003563) | 2.94916527 |
47 | Ketosis (HP:0001946) | 2.92733831 |
48 | Abnormality of renin-angiotensin system (HP:0000847) | 2.91014316 |
49 | Renal salt wasting (HP:0000127) | 2.88845953 |
50 | Chorioretinal atrophy (HP:0000533) | 2.88512998 |
51 | Renal tubular acidosis (HP:0001947) | 2.86592995 |
52 | Hyperphosphaturia (HP:0003109) | 2.82608601 |
53 | Generalized aminoaciduria (HP:0002909) | 2.82090084 |
54 | Hyperammonemia (HP:0001987) | 2.77910287 |
55 | Tubular atrophy (HP:0000092) | 2.69047602 |
56 | Pigmentary retinal degeneration (HP:0001146) | 2.68048328 |
57 | Ileus (HP:0002595) | 2.65871290 |
58 | Fetal akinesia sequence (HP:0001989) | 2.64297712 |
59 | Hypothermia (HP:0002045) | 2.62118184 |
60 | Pancreatic cysts (HP:0001737) | 2.61197085 |
61 | Abnormality of serum amino acid levels (HP:0003112) | 2.55320945 |
62 | Megaloblastic anemia (HP:0001889) | 2.53228384 |
63 | Lethargy (HP:0001254) | 2.52640195 |
64 | Dicarboxylic aciduria (HP:0003215) | 2.52588185 |
65 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.52588185 |
66 | Fatigue (HP:0012378) | 2.49393912 |
67 | Abnormal urine phosphate concentration (HP:0012599) | 2.49091504 |
68 | Abnormality of macular pigmentation (HP:0008002) | 2.47781255 |
69 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.47460598 |
70 | Metabolic acidosis (HP:0001942) | 2.44859366 |
71 | Abnormality of the renal cortex (HP:0011035) | 2.44715382 |
72 | Macrocytic anemia (HP:0001972) | 2.42198494 |
73 | Abnormality of proline metabolism (HP:0010907) | 2.40886525 |
74 | Hydroxyprolinuria (HP:0003080) | 2.40886525 |
75 | Hypoalbuminemia (HP:0003073) | 2.39907222 |
76 | Abnormal albumin level (HP:0012116) | 2.39907222 |
77 | Hyperventilation (HP:0002883) | 2.39875361 |
78 | Pendular nystagmus (HP:0012043) | 2.38558825 |
79 | Abnormality of potassium homeostasis (HP:0011042) | 2.35847971 |
80 | Vascular calcification (HP:0004934) | 2.33986955 |
81 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.31828491 |
82 | Nephrolithiasis (HP:0000787) | 2.29644003 |
83 | Enlarged epiphyses (HP:0010580) | 2.29615090 |
84 | Vomiting (HP:0002013) | 2.29279380 |
85 | Reduced antithrombin III activity (HP:0001976) | 2.27622587 |
86 | Malnutrition (HP:0004395) | 2.26689444 |
87 | Abnormality of vitamin metabolism (HP:0100508) | 2.25052789 |
88 | Delayed CNS myelination (HP:0002188) | 2.24579868 |
89 | Fat malabsorption (HP:0002630) | 2.24283333 |
90 | Attenuation of retinal blood vessels (HP:0007843) | 2.23958701 |
91 | Abnormality of the renal medulla (HP:0100957) | 2.22014434 |
92 | Methylmalonic aciduria (HP:0012120) | 2.20049503 |
93 | Cerebellar dysplasia (HP:0007033) | 2.19395738 |
94 | Acute encephalopathy (HP:0006846) | 2.18753230 |
95 | Rickets (HP:0002748) | 2.18711672 |
96 | Hypokalemia (HP:0002900) | 2.14832241 |
97 | Molar tooth sign on MRI (HP:0002419) | 2.13911654 |
98 | Abnormality of midbrain morphology (HP:0002418) | 2.13911654 |
99 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.13390534 |
100 | Epidermoid cyst (HP:0200040) | 2.11418746 |
101 | Abnormality of renal resorption (HP:0011038) | 2.08070055 |
102 | Cardiovascular calcification (HP:0011915) | 2.07246752 |
103 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.07051968 |
104 | Renal tubular dysfunction (HP:0000124) | 2.05220765 |
105 | Abolished electroretinogram (ERG) (HP:0000550) | 2.04229375 |
106 | Nausea (HP:0002018) | 2.04000106 |
107 | Metaphyseal irregularity (HP:0003025) | 2.03747672 |
108 | Nephrocalcinosis (HP:0000121) | 2.03009033 |
109 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.01633413 |
110 | Nephronophthisis (HP:0000090) | 2.01253772 |
111 | Xanthomatosis (HP:0000991) | 2.00121756 |
112 | Widely patent fontanelles and sutures (HP:0004492) | 1.99051411 |
113 | Male infertility (HP:0003251) | 1.96846519 |
114 | Chronic hepatic failure (HP:0100626) | 1.96661628 |
115 | Type II lissencephaly (HP:0007260) | 1.96656606 |
116 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.96285017 |
117 | Hypoplasia of the fovea (HP:0007750) | 1.96285017 |
118 | Hypophosphatemia (HP:0002148) | 1.94805696 |
119 | Amelogenesis imperfecta (HP:0000705) | 1.94482845 |
120 | Amniotic constriction ring (HP:0009775) | 1.93872131 |
121 | Abnormality of placental membranes (HP:0011409) | 1.93872131 |
122 | Abnormal tarsal ossification (HP:0008369) | 1.93160702 |
123 | Ulnar claw (HP:0001178) | 1.93002769 |
124 | Distal lower limb muscle weakness (HP:0009053) | 1.90651607 |
125 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 1.90276015 |
126 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.89837196 |
127 | Abnormality of alanine metabolism (HP:0010916) | 1.89837196 |
128 | Hyperalaninemia (HP:0003348) | 1.89837196 |
129 | Severe visual impairment (HP:0001141) | 1.89113705 |
130 | Hepatic necrosis (HP:0002605) | 1.88940911 |
131 | Posterior subcapsular cataract (HP:0007787) | 1.88917132 |
132 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.86368993 |
133 | Hypophosphatemic rickets (HP:0004912) | 1.85097914 |
134 | Enlarged kidneys (HP:0000105) | 1.83921197 |
135 | Thin bony cortex (HP:0002753) | 1.82396882 |
136 | Hypokinesia (HP:0002375) | 1.81881760 |
137 | Mesomelia (HP:0003027) | 1.81105641 |
138 | Pancreatic fibrosis (HP:0100732) | 1.79100698 |
139 | True hermaphroditism (HP:0010459) | 1.76028225 |
140 | Disproportionate short-trunk short stature (HP:0003521) | 1.74304052 |
Rank | Gene Set | Z-score |
---|---|---|
1 | OXSR1 | 5.62136315 |
2 | WNK3 | 5.05376097 |
3 | CASK | 4.34078850 |
4 | ACVR1B | 4.30666714 |
5 | NME1 | 3.90587793 |
6 | WNK4 | 3.90418522 |
7 | PKN2 | 3.58621856 |
8 | STK38L | 3.34750045 |
9 | CDK19 | 2.72471813 |
10 | LMTK2 | 2.68578741 |
11 | ADRBK2 | 2.63739486 |
12 | DAPK2 | 2.52216147 |
13 | TAOK3 | 2.36418141 |
14 | MAP4K2 | 2.21984402 |
15 | TNIK | 2.14263013 |
16 | CCNB1 | 2.11512085 |
17 | LATS1 | 2.07924089 |
18 | FLT3 | 2.01579700 |
19 | IRAK3 | 1.92960103 |
20 | BMPR1B | 1.91192911 |
21 | STK39 | 1.91074594 |
22 | PRKCH | 1.80666603 |
23 | NUAK1 | 1.74673776 |
24 | TXK | 1.71185022 |
25 | MST1R | 1.64722918 |
26 | PIK3CG | 1.63901957 |
27 | TTK | 1.62998813 |
28 | MAP4K1 | 1.59573316 |
29 | ERBB4 | 1.59351047 |
30 | MST4 | 1.58803459 |
31 | PINK1 | 1.45441187 |
32 | TRIM28 | 1.41909490 |
33 | AKT3 | 1.39503898 |
34 | EPHA2 | 1.33697011 |
35 | PASK | 1.27758473 |
36 | MUSK | 1.25254820 |
37 | EPHA3 | 1.24777506 |
38 | CDK12 | 1.23642728 |
39 | MAP3K12 | 1.18673972 |
40 | STK38 | 1.16477976 |
41 | EEF2K | 1.15392403 |
42 | MAP3K6 | 1.11926258 |
43 | TYRO3 | 1.10768615 |
44 | FGFR2 | 1.10763044 |
45 | ZAK | 1.08111461 |
46 | NEK1 | 1.07466073 |
47 | GRK1 | 1.04701545 |
48 | PIK3CA | 1.04640249 |
49 | LATS2 | 1.02118647 |
50 | PAK3 | 1.01226976 |
51 | EPHA4 | 0.97546684 |
52 | STK11 | 0.96009517 |
53 | SGK494 | 0.94207828 |
54 | SGK223 | 0.94207828 |
55 | MAP2K6 | 0.92958005 |
56 | MET | 0.92306134 |
57 | MAPK13 | 0.91952467 |
58 | INSRR | 0.91674804 |
59 | PRKCE | 0.90923980 |
60 | BMPR2 | 0.88977718 |
61 | TLK1 | 0.85479129 |
62 | MAP2K4 | 0.82954332 |
63 | EPHB2 | 0.82080172 |
64 | BCKDK | 0.80384626 |
65 | TRPM7 | 0.79199098 |
66 | FRK | 0.77725186 |
67 | MAP3K2 | 0.77530018 |
68 | STK3 | 0.76138905 |
69 | MAPK11 | 0.75627596 |
70 | IKBKB | 0.75613548 |
71 | TNK2 | 0.74733026 |
72 | MAP3K4 | 0.73279783 |
73 | SGK2 | 0.69087095 |
74 | MAP3K8 | 0.67751822 |
75 | IRAK1 | 0.67282102 |
76 | MELK | 0.66616984 |
77 | MAP3K14 | 0.64499175 |
78 | PRKCQ | 0.62820865 |
79 | MAP3K7 | 0.62607116 |
80 | PDK3 | 0.61176962 |
81 | PDK4 | 0.61176962 |
82 | PRKCZ | 0.61173514 |
83 | MAP2K7 | 0.60566362 |
84 | NEK9 | 0.59032612 |
85 | FES | 0.58973980 |
86 | CAMK2D | 0.58969685 |
87 | BRD4 | 0.58017526 |
88 | PRKD3 | 0.57595010 |
89 | CAMKK1 | 0.57256611 |
90 | SGK1 | 0.54824426 |
91 | PDK2 | 0.52901721 |
92 | BCR | 0.50330495 |
93 | LCK | 0.48981853 |
94 | PHKG1 | 0.48299826 |
95 | PHKG2 | 0.48299826 |
96 | PBK | 0.47335114 |
97 | EPHB1 | 0.47249454 |
98 | FER | 0.46507072 |
99 | STK16 | 0.45983455 |
100 | RPS6KA4 | 0.45481677 |
101 | CDK8 | 0.45407299 |
102 | GRK6 | 0.44549984 |
103 | PRKCD | 0.44511940 |
104 | PRKACG | 0.44277287 |
105 | EIF2AK2 | 0.44187150 |
106 | PRKCG | 0.43756994 |
107 | MAP3K13 | 0.43460545 |
108 | PTK2B | 0.42941231 |
109 | PRKG2 | 0.41805058 |
110 | ITK | 0.41255818 |
111 | TIE1 | 0.40859298 |
112 | MAP2K2 | 0.40409974 |
113 | PDK1 | 0.39977060 |
114 | FGFR4 | 0.39397631 |
115 | CSNK1G1 | 0.39044317 |
116 | BRAF | 0.38845268 |
117 | PLK2 | 0.38697086 |
118 | MAP3K11 | 0.38416559 |
119 | MAP3K1 | 0.38350298 |
120 | AURKB | 0.36743144 |
121 | STK10 | 0.36272708 |
122 | WNK1 | 0.35734896 |
123 | ABL2 | 0.35656166 |
124 | JAK2 | 0.34842901 |
125 | NEK2 | 0.32439538 |
126 | EIF2AK3 | 0.32414203 |
127 | CAMK2A | 0.32296116 |
128 | IGF1R | 0.32209669 |
129 | CSNK1A1L | 0.32110094 |
130 | PRKCI | 0.30873109 |
131 | ERBB3 | 0.30759106 |
132 | NLK | 0.30616726 |
133 | SRC | 0.30183217 |
134 | GSK3A | 0.30172101 |
135 | PRKAA2 | 0.29677445 |
136 | CDC42BPA | 0.29331942 |
137 | PRKCA | 0.28732175 |
138 | RIPK1 | 0.28084170 |
139 | MYLK | 0.27764423 |
140 | CHUK | 0.27712864 |
141 | CSNK1G3 | 0.27261893 |
142 | SGK3 | 0.26933551 |
143 | RPS6KB2 | 0.26840299 |
144 | TEC | 0.26750380 |
145 | EIF2AK1 | 0.25420512 |
146 | AKT2 | 0.24287732 |
147 | PLK1 | 0.23958473 |
148 | MAPKAPK5 | 0.23777894 |
149 | ADRBK1 | 0.23120682 |
150 | CSNK1A1 | 0.22105519 |
151 | PRKAA1 | 0.21871848 |
152 | DAPK1 | 0.21603153 |
153 | CDK9 | 0.21350631 |
154 | ERBB2 | 0.21297783 |
155 | RET | 0.20538821 |
156 | PDPK1 | 0.20353637 |
157 | PRKACA | 0.19325734 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 3.85041686 |
2 | Fat digestion and absorption_Homo sapiens_hsa04975 | 3.45829300 |
3 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 3.27524229 |
4 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.07506791 |
5 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 2.81515547 |
6 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.78200939 |
7 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.76605493 |
8 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.63691851 |
9 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.55944883 |
10 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.53435937 |
11 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.53334869 |
12 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 2.47055544 |
13 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.42101306 |
14 | Peroxisome_Homo sapiens_hsa04146 | 2.27831968 |
15 | Selenocompound metabolism_Homo sapiens_hsa00450 | 2.22665641 |
16 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.20470679 |
17 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.14231827 |
18 | Other glycan degradation_Homo sapiens_hsa00511 | 2.08206990 |
19 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.99735100 |
20 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.92119097 |
21 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.90121535 |
22 | Bile secretion_Homo sapiens_hsa04976 | 1.85821717 |
23 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.81127721 |
24 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.78467612 |
25 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.77870358 |
26 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.76506501 |
27 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.65109510 |
28 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.63376899 |
29 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.59652302 |
30 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.57865923 |
31 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.56167294 |
32 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.55135424 |
33 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.54127976 |
34 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.52745658 |
35 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.45917584 |
36 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.40801779 |
37 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.28792873 |
38 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.27566769 |
39 | Histidine metabolism_Homo sapiens_hsa00340 | 1.26650709 |
40 | Retinol metabolism_Homo sapiens_hsa00830 | 1.26237091 |
41 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.24428349 |
42 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.23948934 |
43 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.21323405 |
44 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.19128922 |
45 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.18986291 |
46 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.18577827 |
47 | Galactose metabolism_Homo sapiens_hsa00052 | 1.15604987 |
48 | Mineral absorption_Homo sapiens_hsa04978 | 1.11816958 |
49 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.11502847 |
50 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.11284705 |
51 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.10391051 |
52 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.05284383 |
53 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.04010790 |
54 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.02699402 |
55 | Carbon metabolism_Homo sapiens_hsa01200 | 1.01192184 |
56 | Parkinsons disease_Homo sapiens_hsa05012 | 0.97764401 |
57 | Phototransduction_Homo sapiens_hsa04744 | 0.97673725 |
58 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.97113114 |
59 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.94978300 |
60 | Lysine degradation_Homo sapiens_hsa00310 | 0.94795316 |
61 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.94383195 |
62 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.91793045 |
63 | Sulfur relay system_Homo sapiens_hsa04122 | 0.88695179 |
64 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.84363963 |
65 | ABC transporters_Homo sapiens_hsa02010 | 0.84171935 |
66 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.83761868 |
67 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.82932614 |
68 | Allograft rejection_Homo sapiens_hsa05330 | 0.82296263 |
69 | Asthma_Homo sapiens_hsa05310 | 0.81897332 |
70 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.79838236 |
71 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.78458819 |
72 | Ribosome_Homo sapiens_hsa03010 | 0.77877081 |
73 | Metabolic pathways_Homo sapiens_hsa01100 | 0.75815615 |
74 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.75484774 |
75 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.74981462 |
76 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.74462198 |
77 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.73969183 |
78 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.70906027 |
79 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.70512596 |
80 | Alzheimers disease_Homo sapiens_hsa05010 | 0.68512375 |
81 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.67668852 |
82 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.66043436 |
83 | Huntingtons disease_Homo sapiens_hsa05016 | 0.64104066 |
84 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.63442497 |
85 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.61178989 |
86 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.60616807 |
87 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.60531680 |
88 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.60366825 |
89 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.59857119 |
90 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.59349802 |
91 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.57313895 |
92 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.57179149 |
93 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.55669604 |
94 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.54334513 |
95 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.52271013 |
96 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.52266151 |
97 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.50383581 |
98 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.50080662 |
99 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.49875628 |
100 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.48571961 |
101 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.47786925 |
102 | RNA polymerase_Homo sapiens_hsa03020 | 0.47262867 |
103 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.46320145 |
104 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.43037878 |
105 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.42777320 |
106 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.38458423 |
107 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.38294602 |
108 | Insulin secretion_Homo sapiens_hsa04911 | 0.37966384 |
109 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.37467233 |
110 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.36925555 |
111 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.36780458 |
112 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.35289764 |
113 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.31988429 |
114 | Hepatitis C_Homo sapiens_hsa05160 | 0.31282783 |
115 | Insulin resistance_Homo sapiens_hsa04931 | 0.30816704 |
116 | Bladder cancer_Homo sapiens_hsa05219 | 0.29841828 |
117 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.29489660 |
118 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.28570784 |
119 | Tight junction_Homo sapiens_hsa04530 | 0.28229534 |
120 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.25694737 |
121 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.25592498 |
122 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.24576061 |
123 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.21929732 |
124 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.21539173 |
125 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.20681026 |
126 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.20226898 |
127 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.19851384 |
128 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.19420084 |
129 | Cocaine addiction_Homo sapiens_hsa05030 | 0.18380340 |
130 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.18006054 |
131 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.17371332 |
132 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.17076575 |
133 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.16136674 |
134 | Pertussis_Homo sapiens_hsa05133 | 0.15104854 |
135 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.13609033 |
136 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.13563529 |
137 | Purine metabolism_Homo sapiens_hsa00230 | 0.12029327 |
138 | Salivary secretion_Homo sapiens_hsa04970 | 0.10951661 |
139 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.10718523 |