SLC24A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* detection of light stimulus (GO:0009583)9.97499770
2retinal rod cell development (GO:0046548)9.84852435
3positive regulation of guanylate cyclase activity (GO:0031284)9.11360628
4* visual perception (GO:0007601)8.66911336
5* sensory perception of light stimulus (GO:0050953)8.57010590
6regulation of guanylate cyclase activity (GO:0031282)8.22989131
7* cellular response to light stimulus (GO:0071482)7.36038531
8* detection of external stimulus (GO:0009581)6.96902264
9eye photoreceptor cell differentiation (GO:0001754)6.89340005
10photoreceptor cell differentiation (GO:0046530)6.89340005
11* detection of abiotic stimulus (GO:0009582)6.82839242
12retina development in camera-type eye (GO:0060041)6.61343888
13regulation of cGMP metabolic process (GO:0030823)6.12396657
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.45142140
15positive regulation of cGMP biosynthetic process (GO:0030828)5.36448902
16adaptation of signaling pathway (GO:0023058)5.08429366
17regulation of cGMP biosynthetic process (GO:0030826)5.03272528
18receptor guanylyl cyclase signaling pathway (GO:0007168)4.75459751
19* cellular response to radiation (GO:0071478)4.72756282
20positive regulation of cGMP metabolic process (GO:0030825)4.72014972
21cell morphogenesis involved in neuron differentiation (GO:0048667)4.69409591
22regulation of establishment of cell polarity (GO:2000114)4.68791653
23nonmotile primary cilium assembly (GO:0035058)4.67691539
24detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.62103814
25regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.47491274
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.46868779
27regulation of clathrin-mediated endocytosis (GO:2000369)4.40716597
28establishment of protein localization to Golgi (GO:0072600)4.22508317
29regulation of establishment or maintenance of cell polarity (GO:0032878)4.14263640
30estrogen biosynthetic process (GO:0006703)4.08578668
31protein prenylation (GO:0018342)4.05881337
32prenylation (GO:0097354)4.05881337
33* sensory perception (GO:0007600)4.04770028
34retina layer formation (GO:0010842)4.02444756
35regulation of voltage-gated calcium channel activity (GO:1901385)3.98313108
36positive regulation of developmental pigmentation (GO:0048087)3.88975692
37negative regulation of smooth muscle cell differentiation (GO:0051151)3.82968898
38hepatocyte apoptotic process (GO:0097284)3.82212479
39* response to light stimulus (GO:0009416)3.81389213
40monoubiquitinated protein deubiquitination (GO:0035520)3.74287254
41interkinetic nuclear migration (GO:0022027)3.68675725
42cilium or flagellum-dependent cell motility (GO:0001539)3.65095957
43protein targeting to Golgi (GO:0000042)3.61904305
44regulation of short-term neuronal synaptic plasticity (GO:0048172)3.61456820
45retrograde transport, vesicle recycling within Golgi (GO:0000301)3.59111673
46regulation of hippo signaling (GO:0035330)3.56606161
47retina homeostasis (GO:0001895)3.56075508
48CDP-diacylglycerol biosynthetic process (GO:0016024)3.56032459
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.55246026
50DNA methylation involved in gamete generation (GO:0043046)3.53972997
51neuron development (GO:0048666)3.53650904
52piRNA metabolic process (GO:0034587)3.53564651
53cellular response to ethanol (GO:0071361)3.52184880
54nephron epithelium morphogenesis (GO:0072088)3.49774290
55nephron tubule morphogenesis (GO:0072078)3.49774290
56negative regulation of receptor-mediated endocytosis (GO:0048261)3.47239234
57protein localization to synapse (GO:0035418)3.46944845
58endosome to pigment granule transport (GO:0043485)3.43936840
59endosome to melanosome transport (GO:0035646)3.43936840
60ovulation from ovarian follicle (GO:0001542)3.34135157
61protein K11-linked deubiquitination (GO:0035871)3.27563438
62CDP-diacylglycerol metabolic process (GO:0046341)3.25265689
63retinoid metabolic process (GO:0001523)3.24672969
64snRNA transcription (GO:0009301)3.23490533
65negative regulation of sodium ion transport (GO:0010766)3.22079284
66positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.18659800
67synaptic vesicle maturation (GO:0016188)3.13853066
68positive regulation of neurotransmitter transport (GO:0051590)3.13507927
69short-term memory (GO:0007614)3.13415703
70membrane hyperpolarization (GO:0060081)3.12711069
71Golgi to endosome transport (GO:0006895)3.07702976
72neural tube formation (GO:0001841)3.06788577
73phospholipid translocation (GO:0045332)3.06540122
74lipid translocation (GO:0034204)3.06540122
75positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.05335832
76reflex (GO:0060004)3.04812492
77protein localization to Golgi apparatus (GO:0034067)3.01733975
78diterpenoid metabolic process (GO:0016101)3.01291443
79behavioral response to ethanol (GO:0048149)3.00968889
80peristalsis (GO:0030432)3.00554134
81chemosensory behavior (GO:0007635)3.00332945
82regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.96498217
83regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.96498217
84embryonic hemopoiesis (GO:0035162)2.95292785
85glomerular basement membrane development (GO:0032836)2.94730620
86synaptic vesicle docking involved in exocytosis (GO:0016081)2.94697654
87negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.91138908
88negative regulation of translation, ncRNA-mediated (GO:0040033)2.91138908
89regulation of translation, ncRNA-mediated (GO:0045974)2.91138908
90negative regulation of execution phase of apoptosis (GO:1900118)2.90604431
91positive regulation of sodium ion transmembrane transport (GO:1902307)2.86902302
92response to histamine (GO:0034776)2.86894982
93regulation of penile erection (GO:0060405)2.85882229
94artery development (GO:0060840)2.84679313
95peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.83199308
96histone mRNA catabolic process (GO:0071044)2.78891049
97meiotic chromosome segregation (GO:0045132)2.78179691
98renal tubule morphogenesis (GO:0061333)2.78023732
99positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.77088268
100early endosome to late endosome transport (GO:0045022)2.76061442
101terpenoid metabolic process (GO:0006721)2.75545650
102phasic smooth muscle contraction (GO:0014821)2.74692094
103detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74263366
104negative regulation of cAMP-mediated signaling (GO:0043951)2.74141096
105striated muscle atrophy (GO:0014891)2.73189337
106histone H3-K4 trimethylation (GO:0080182)2.73139294
107post-embryonic morphogenesis (GO:0009886)2.72928129
108protein K48-linked deubiquitination (GO:0071108)2.72876748
109axoneme assembly (GO:0035082)2.69965442
110retinol metabolic process (GO:0042572)2.66922665
111intra-Golgi vesicle-mediated transport (GO:0006891)2.65299332
112regulation of pigment cell differentiation (GO:0050932)2.63356647
113icosanoid secretion (GO:0032309)2.62956432
114arachidonic acid secretion (GO:0050482)2.62956432
115fatty acid transmembrane transport (GO:1902001)2.62818010
116phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.62715993
117cellular response to ATP (GO:0071318)2.61709862
118negative regulation of cation channel activity (GO:2001258)2.60703730
119lipoprotein transport (GO:0042953)2.60464851
120* response to radiation (GO:0009314)2.59971668
121protein K63-linked deubiquitination (GO:0070536)2.58645706
122positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.58055314
123detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.57694727
124synapsis (GO:0007129)2.57687179
125negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.56559658
126negative regulation of calcium ion transmembrane transport (GO:1903170)2.56559658
127dopamine receptor signaling pathway (GO:0007212)2.56413670
128hematopoietic stem cell proliferation (GO:0071425)2.54654698
129tryptophan catabolic process (GO:0006569)2.52561864
130indole-containing compound catabolic process (GO:0042436)2.52561864
131indolalkylamine catabolic process (GO:0046218)2.52561864
132cellular biogenic amine catabolic process (GO:0042402)2.51985110
133amine catabolic process (GO:0009310)2.51985110
134intestinal epithelial cell development (GO:0060576)2.50616730
135establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.49470671
136mitochondrion transport along microtubule (GO:0047497)2.49470671
137musculoskeletal movement (GO:0050881)2.49315972
138multicellular organismal movement (GO:0050879)2.49315972
139sodium ion export (GO:0071436)2.48140220
140negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47642664
141positive regulation of granulocyte differentiation (GO:0030854)2.46146575
142inositol phosphate-mediated signaling (GO:0048016)2.45447697
143regulation of nuclear cell cycle DNA replication (GO:0033262)2.45065828
144negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.44682955
145carnitine transport (GO:0015879)2.44297369
146amino-acid betaine transport (GO:0015838)2.44297369
147recombinational repair (GO:0000725)2.43452702
148fucose catabolic process (GO:0019317)2.41718983
149L-fucose metabolic process (GO:0042354)2.41718983
150L-fucose catabolic process (GO:0042355)2.41718983
151detection of chemical stimulus involved in sensory perception (GO:0050907)2.41482315
152negative regulation of B cell proliferation (GO:0030889)2.41412547
153positive regulation of ERBB signaling pathway (GO:1901186)2.40579087
154double-strand break repair via homologous recombination (GO:0000724)2.40416572
155epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40303111
156DNA methylation (GO:0006306)2.39512923
157DNA alkylation (GO:0006305)2.39512923
158* cellular response to abiotic stimulus (GO:0071214)2.39378755
159rRNA catabolic process (GO:0016075)2.39368375
160mannosylation (GO:0097502)2.39196470
161gene silencing by RNA (GO:0031047)2.38610462
162vitamin A metabolic process (GO:0006776)2.38052353
163ear development (GO:0043583)2.37244590
164cardiovascular system development (GO:0072358)2.37096003
165left/right axis specification (GO:0070986)2.36663330
166cellular potassium ion homeostasis (GO:0030007)2.34735349
167skeletal muscle adaptation (GO:0043501)2.33126759
168lactate metabolic process (GO:0006089)2.32728531
169carnitine transmembrane transport (GO:1902603)2.31791571
170righting reflex (GO:0060013)2.30819317
171melanocyte differentiation (GO:0030318)2.30672755
172histone H3-K36 demethylation (GO:0070544)2.29045515
173pigment cell differentiation (GO:0050931)2.28360128
174keratinocyte development (GO:0003334)2.28151154
175regulation of hexokinase activity (GO:1903299)2.27278356
176regulation of glucokinase activity (GO:0033131)2.27278356
177T cell lineage commitment (GO:0002360)2.27178045
178nodal signaling pathway (GO:0038092)2.26671966
179organic cation transport (GO:0015695)2.26570049
180histone H3-K9 methylation (GO:0051567)2.25944263
181regulation of rhodopsin mediated signaling pathway (GO:0022400)18.8624834
182* rhodopsin mediated signaling pathway (GO:0016056)17.7178201
183retinal cone cell development (GO:0046549)14.4133759
184photoreceptor cell development (GO:0042461)12.0619254
185photoreceptor cell maintenance (GO:0045494)12.0247949
186detection of light stimulus involved in sensory perception (GO:0050962)11.3982869
187detection of light stimulus involved in visual perception (GO:0050908)11.3982869
188eye photoreceptor cell development (GO:0042462)11.3600024
189* phototransduction (GO:0007602)10.5447104
190* phototransduction, visible light (GO:0007603)10.5398076
191GMP metabolic process (GO:0046037)10.3709694
192protein-chromophore linkage (GO:0018298)10.0956910
193* detection of visible light (GO:0009584)10.0147556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.28071794
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.14875045
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.31619757
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.09729149
5ZNF274_21170338_ChIP-Seq_K562_Hela2.83673906
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.72953629
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.68430195
8GBX2_23144817_ChIP-Seq_PC3_Human2.63163048
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.55921753
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.40582420
11DROSHA_22980978_ChIP-Seq_HELA_Human2.40375861
12GATA1_22025678_ChIP-Seq_K562_Human2.37740088
13VDR_22108803_ChIP-Seq_LS180_Human2.27622883
14DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.15564795
15TP53_16413492_ChIP-PET_HCT116_Human2.11571192
16BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.09490437
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.08211520
18AR_21572438_ChIP-Seq_LNCaP_Human2.03049429
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01922195
20ER_23166858_ChIP-Seq_MCF-7_Human2.00484233
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.97701332
22EWS_26573619_Chip-Seq_HEK293_Human1.95217491
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88517903
24SMAD3_21741376_ChIP-Seq_HESCs_Human1.85906506
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80825955
26KDM2B_26808549_Chip-Seq_K562_Human1.80460566
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77682488
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.75797716
29TAF15_26573619_Chip-Seq_HEK293_Human1.73911179
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73717739
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.72176805
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71843248
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69461281
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69369444
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.68066861
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.67527217
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67405933
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.66469641
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.66231826
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.65469213
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65288148
42AR_19668381_ChIP-Seq_PC3_Human1.63328469
43REST_21632747_ChIP-Seq_MESCs_Mouse1.62543708
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61431705
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59920732
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59524041
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.58992292
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.55334500
49P53_22127205_ChIP-Seq_FIBROBLAST_Human1.49998366
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49689463
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.46993212
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46267821
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46076487
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.44857185
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.44774851
56TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.43416321
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41375281
58CDX2_22108803_ChIP-Seq_LS180_Human1.40158520
59CBP_20019798_ChIP-Seq_JUKART_Human1.40103266
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40103266
61SMAD4_21799915_ChIP-Seq_A2780_Human1.39802393
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39020588
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38092382
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37525044
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37175166
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.35824115
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35619165
68RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35619165
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34627567
70FUS_26573619_Chip-Seq_HEK293_Human1.32014449
71TBL1_22424771_ChIP-Seq_293T_Human1.31493283
72IGF1R_20145208_ChIP-Seq_DFB_Human1.30986971
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.29964262
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.28690185
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28649574
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27607425
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27548548
78CTCF_27219007_Chip-Seq_Bcells_Human1.27325850
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27137700
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27137700
81STAT3_23295773_ChIP-Seq_U87_Human1.25422262
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25379231
83AR_25329375_ChIP-Seq_VCAP_Human1.23130490
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22222397
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22093142
86CREB1_26743006_Chip-Seq_LNCaP_Human1.21053849
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.20772635
88JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20733315
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19873765
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.19265286
91TCF4_22108803_ChIP-Seq_LS180_Human1.19146392
92BCAT_22108803_ChIP-Seq_LS180_Human1.18899550
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18744545
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.18541853
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17644460
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.17553480
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.16643257
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16332861
99ISL1_27105846_Chip-Seq_CPCs_Mouse1.16281488
100CJUN_26792858_Chip-Seq_BT549_Human1.16101823
101DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15033554
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15018814
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14628017
104CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12745525
105NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.12576045
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11957669
107RUNX2_22187159_ChIP-Seq_PCA_Human1.11789480
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.11708739
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10698125
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10147531
111* SMC4_20622854_ChIP-Seq_HELA_Human1.09815910
112HOXB7_26014856_ChIP-Seq_BT474_Human1.09710691
113WDR5_24793694_ChIP-Seq_LNCAP_Human1.09629646
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09361098
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09258065
116BRD4_25478319_ChIP-Seq_HGPS_Human1.08300387
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07613936
118SMAD4_21741376_ChIP-Seq_HESCs_Human1.07536078
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07323495
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06384045
121OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06380473
122CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05992395
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.05890185
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05852012
125GATA3_26560356_Chip-Seq_TH2_Human1.05625633
126ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04689307
127STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04205400
128EZH2_27304074_Chip-Seq_ESCs_Mouse1.04083097
129TAF2_19829295_ChIP-Seq_ESCs_Human1.03205772
130TP63_19390658_ChIP-ChIP_HaCaT_Human1.03159624
131ESR1_21235772_ChIP-Seq_MCF-7_Human1.02296931
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01940230
133YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01741470
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01026973
135NFE2_27457419_Chip-Seq_LIVER_Mouse1.01004793
136DPY_21335234_ChIP-Seq_ESCs_Mouse1.00758728
137MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00576660
138SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00425536
139SCL_19346495_ChIP-Seq_HPC-7_Human1.00326358
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00287320
141FOXA1_25552417_ChIP-Seq_VCAP_Human0.99926187
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.99701475
143TP63_23658742_ChIP-Seq_EP156T_Human0.99538720
144RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98583209
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98456344
146* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98259984
147* FOXA1_25329375_ChIP-Seq_VCAP_Human0.98259984
148EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97482021
149CBP_21632823_ChIP-Seq_H3396_Human0.96877937
150P300_19829295_ChIP-Seq_ESCs_Human0.96122995
151* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94985373
152WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94963402
153AHR_22903824_ChIP-Seq_MCF-7_Human0.93950892
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93760934
155ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93509735
156NCOR_22424771_ChIP-Seq_293T_Human0.93357643
157TCF4_23295773_ChIP-Seq_U87_Human0.92767565
158* OCT1_27270436_Chip-Seq_PROSTATE_Human0.92134443
159JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90843669
160ERG_21242973_ChIP-ChIP_JURKAT_Human0.90668149
161RUNX_20019798_ChIP-Seq_JUKART_Human0.90315625
162EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89337922
163ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87997468
164RING1B_27294783_Chip-Seq_ESCs_Mouse0.87943860
165* GATA1_19941827_ChIP-Seq_MEL_Mouse0.87923737
166MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87368437
167TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86356858
168FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86161127
169TP53_23651856_ChIP-Seq_MEFs_Mouse0.86032043
170* P68_20966046_ChIP-Seq_HELA_Human0.85157017
171TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83478249
172SMAD3_21741376_ChIP-Seq_ESCs_Human0.82784193
173TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82566837
174VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81879069
175RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.81844597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.53329427
2MP0005253_abnormal_eye_physiology6.77556439
3MP0006072_abnormal_retinal_apoptosis6.29554749
4MP0000569_abnormal_digit_pigmentation5.34728325
5MP0003195_calcinosis4.04675809
6MP0003950_abnormal_plasma_membrane3.87419329
7MP0005195_abnormal_posterior_eye3.78602793
8MP0008057_abnormal_DNA_replication3.68459136
9MP0001324_abnormal_eye_pigmentation3.60377212
10MP0005391_vision/eye_phenotype3.27406616
11MP0002090_abnormal_vision3.15296063
12MP0008877_abnormal_DNA_methylation2.80355566
13MP0002638_abnormal_pupillary_reflex2.76492677
14MP0005423_abnormal_somatic_nervous2.69663175
15MP0002229_neurodegeneration2.63758087
16MP0005451_abnormal_body_composition2.56436108
17MP0002009_preneoplasia2.41676290
18MP0000371_diluted_coat_color2.32873718
19MP0002166_altered_tumor_susceptibility2.31686871
20MP0000015_abnormal_ear_pigmentation2.27735523
21MP0000383_abnormal_hair_follicle2.25137941
22MP0006054_spinal_hemorrhage2.23535989
23MP0001764_abnormal_homeostasis2.11174800
24MP0005408_hypopigmentation2.11153091
25MP0000372_irregular_coat_pigmentation2.01503850
26MP0003011_delayed_dark_adaptation11.7110879
27MP0004381_abnormal_hair_follicle1.97013443
28MP0002139_abnormal_hepatobiliary_system1.91726030
29MP0005174_abnormal_tail_pigmentation1.88322452
30MP0001986_abnormal_taste_sensitivity1.87006591
31MP0002752_abnormal_somatic_nervous1.86673083
32MP0010678_abnormal_skin_adnexa1.86220255
33MP0005645_abnormal_hypothalamus_physiol1.84905209
34MP0000427_abnormal_hair_cycle1.84665415
35MP0005075_abnormal_melanosome_morpholog1.82186969
36MP0003787_abnormal_imprinting1.81704436
37MP0008875_abnormal_xenobiotic_pharmacok1.70233742
38MP0001873_stomach_inflammation1.64884002
39MP0004019_abnormal_vitamin_homeostasis1.56926258
40MP0002876_abnormal_thyroid_physiology1.55411570
41MP0002254_reproductive_system_inflammat1.52547370
42MP0000013_abnormal_adipose_tissue1.52172403
43MP0002160_abnormal_reproductive_system1.46680686
44MP0002653_abnormal_ependyma_morphology1.46218949
45MP0002877_abnormal_melanocyte_morpholog1.45531473
46MP0002138_abnormal_hepatobiliary_system1.42769702
47MP0002006_tumorigenesis1.42726094
48MP0003183_abnormal_peptide_metabolism1.42308380
49MP0002882_abnormal_neuron_morphology1.36662626
50MP0008872_abnormal_physiological_respon1.34257576
51MP0005310_abnormal_salivary_gland1.33806784
52MP0003172_abnormal_lysosome_physiology1.28710020
53MP0005220_abnormal_exocrine_pancreas1.28155782
54MP0005379_endocrine/exocrine_gland_phen1.26323363
55MP0001756_abnormal_urination1.25475069
56MP0004233_abnormal_muscle_weight1.23184595
57MP0005389_reproductive_system_phenotype1.21085695
58MP0002168_other_aberrant_phenotype1.20611674
59MP0005646_abnormal_pituitary_gland1.19720636
60MP0002075_abnormal_coat/hair_pigmentati1.16581279
61MP0005647_abnormal_sex_gland1.16132079
62MP0010329_abnormal_lipoprotein_level1.15608187
63MP0008995_early_reproductive_senescence1.15328032
64MP0002396_abnormal_hematopoietic_system1.14781512
65MP0004264_abnormal_extraembryonic_tissu1.11714828
66MP0002837_dystrophic_cardiac_calcinosis1.10049098
67MP0001545_abnormal_hematopoietic_system1.04522270
68MP0005397_hematopoietic_system_phenotyp1.04522270
69MP0004270_analgesia1.00308318
70MP0001502_abnormal_circadian_rhythm0.99540739
71MP0004885_abnormal_endolymph0.98264110
72MP0000003_abnormal_adipose_tissue0.97579468
73MP0005197_abnormal_uvea_morphology0.94062480
74MP0002095_abnormal_skin_pigmentation0.92418361
75MP0005167_abnormal_blood-brain_barrier0.92330788
76MP0001800_abnormal_humoral_immune0.91882062
77MP0001984_abnormal_olfaction0.91221638
78MP0010307_abnormal_tumor_latency0.90673641
79MP0002933_joint_inflammation0.89843905
80MP0000516_abnormal_urinary_system0.87872929
81MP0005367_renal/urinary_system_phenotyp0.87872929
82MP0000230_abnormal_systemic_arterial0.86748975
83MP0001486_abnormal_startle_reflex0.85106591
84MP0001501_abnormal_sleep_pattern0.83359934
85MP0002332_abnormal_exercise_endurance0.82263530
86MP0002693_abnormal_pancreas_physiology0.82256301
87MP0001186_pigmentation_phenotype0.81570725
88MP0005395_other_phenotype0.79125152
89MP0003634_abnormal_glial_cell0.77868342
90MP0003763_abnormal_thymus_physiology0.76882785
91MP0000639_abnormal_adrenal_gland0.75595541
92MP0001666_abnormal_nutrient_absorption0.75291235
93MP0005332_abnormal_amino_acid0.74248231
94MP0005671_abnormal_response_to0.73035204
95MP0010094_abnormal_chromosome_stability0.71374476
96MP0002136_abnormal_kidney_physiology0.71253136
97MP0001944_abnormal_pancreas_morphology0.70386052
98MP0003880_abnormal_central_pattern0.69669176
99MP0002272_abnormal_nervous_system0.69598173
100MP0005365_abnormal_bile_salt0.69236478
101MP0001919_abnormal_reproductive_system0.68359985
102MP0005187_abnormal_penis_morphology0.67915862
103MP0006292_abnormal_olfactory_placode0.67432727
104MP0010352_gastrointestinal_tract_polyps0.67360196
105MP0002127_abnormal_cardiovascular_syste0.66802112
106MP0005499_abnormal_olfactory_system0.66656380
107MP0005394_taste/olfaction_phenotype0.66656380
108MP0005083_abnormal_biliary_tract0.65548557
109MP0000470_abnormal_stomach_morphology0.65302491
110MP0005410_abnormal_fertilization0.64938189
111MP0003718_maternal_effect0.64286081
112MP0004859_abnormal_synaptic_plasticity0.62645515
113MP0000685_abnormal_immune_system0.59163519
114MP0001765_abnormal_ion_homeostasis0.58100787
115MP0009046_muscle_twitch0.58030334
116MP0005164_abnormal_response_to0.57754710
117MP0002734_abnormal_mechanical_nocicepti0.55693882
118MP0002064_seizures0.55421436
119MP0001286_abnormal_eye_development0.54282972
120MP0003635_abnormal_synaptic_transmissio0.53298320
121MP0000465_gastrointestinal_hemorrhage0.52814777
122MP0005376_homeostasis/metabolism_phenot0.48298277
123MP0008789_abnormal_olfactory_epithelium0.46586403
124MP0001963_abnormal_hearing_physiology0.46333038
125MP0002063_abnormal_learning/memory/cond0.39319243
126MP0002067_abnormal_sensory_capabilities0.38032469
127MP0004215_abnormal_myocardial_fiber0.36671126
128MP0001968_abnormal_touch/_nociception0.36329282
129MP0002572_abnormal_emotion/affect_behav0.33705605
130MP0005386_behavior/neurological_phenoty0.33514996
131MP0004924_abnormal_behavior0.33514996
132MP0009745_abnormal_behavioral_response0.32666519
133MP0003045_fibrosis0.32447845
134MP0008004_abnormal_stomach_pH0.30569022
135MP0004742_abnormal_vestibular_system0.29148766
136MP0004085_abnormal_heartbeat0.27563401
137MP0008569_lethality_at_weaning0.27537396
138MP0009780_abnormal_chondrocyte_physiolo0.26786471
139MP0002697_abnormal_eye_size0.26215864
140MP0005248_abnormal_Harderian_gland0.26110789
141MP0005620_abnormal_muscle_contractility0.25799010
142MP0005076_abnormal_cell_differentiation0.25175585
143MP0004145_abnormal_muscle_electrophysio0.24225358
144MP0002102_abnormal_ear_morphology0.24050985
145MP0001915_intracranial_hemorrhage0.22398424
146MP0003252_abnormal_bile_duct0.22212323
147MP0005193_abnormal_anterior_eye0.21404524
148MP0000026_abnormal_inner_ear0.20533880
149MP0004782_abnormal_surfactant_physiolog0.20394897
150MP0002152_abnormal_brain_morphology0.20393735
151MP0004043_abnormal_pH_regulation0.20380058
152MP0002066_abnormal_motor_capabilities/c0.20307701
153MP0002184_abnormal_innervation0.19906084
154MP0002928_abnormal_bile_duct0.19122982
155MP0004142_abnormal_muscle_tone0.19081987
156MP0004811_abnormal_neuron_physiology0.18586616
157MP0008961_abnormal_basal_metabolism0.16815193
158MP0005595_abnormal_vascular_smooth0.16641324
159MP0003943_abnormal_hepatobiliary_system0.16477040
160MP0003632_abnormal_nervous_system0.16355193
161MP0000631_abnormal_neuroendocrine_gland0.16260958
162MP0002909_abnormal_adrenal_gland0.15565056
163MP0003633_abnormal_nervous_system0.15473844
164MP0003890_abnormal_embryonic-extraembry0.15309270
165MP0003646_muscle_fatigue0.15069106
166MP0000778_abnormal_nervous_system0.14488070
167MP0002108_abnormal_muscle_morphology0.14283120
168MP0004036_abnormal_muscle_relaxation0.12595842
169MP0003631_nervous_system_phenotype0.12130071
170MP0010386_abnormal_urinary_bladder0.12050494
171MP0010368_abnormal_lymphatic_system0.10836996
172MP0005330_cardiomyopathy0.10743853
173MP0005257_abnormal_intraocular_pressure0.08633108
174MP0001661_extended_life_span0.08479217
175MP0002557_abnormal_social/conspecific_i0.08257127
176MP0001970_abnormal_pain_threshold0.08091852
177MP0001879_abnormal_lymphatic_vessel0.08022683
178MP0001905_abnormal_dopamine_level0.08015385
179MP0001177_atelectasis0.07780091
180MP0000001_mammalian_phenotype0.07767911

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.87405720
2Pigmentary retinal degeneration (HP:0001146)8.81551098
3Chorioretinal atrophy (HP:0000533)8.59679883
4Scotoma (HP:0000575)7.99417037
5Dyschromatopsia (HP:0007641)7.93772529
6Attenuation of retinal blood vessels (HP:0007843)7.86327038
7Abnormality of macular pigmentation (HP:0008002)7.85092498
8Pendular nystagmus (HP:0012043)7.71978779
9Abolished electroretinogram (ERG) (HP:0000550)6.65201518
10Decreased central vision (HP:0007663)6.49443824
11Type II diabetes mellitus (HP:0005978)5.67528181
12Photophobia (HP:0000613)5.65066106
13Macular degeneration (HP:0000608)5.15840745
14Keratoconus (HP:0000563)5.06761183
15Increased corneal curvature (HP:0100692)5.06761183
16Cone-rod dystrophy (HP:0000548)4.87304405
17Vitreoretinal degeneration (HP:0000655)4.84635148
18Choroideremia (HP:0001139)4.71839087
19Severe visual impairment (HP:0001141)4.65644260
20Posterior subcapsular cataract (HP:0007787)4.60733530
21Constricted visual fields (HP:0001133)4.59032242
22Retinitis pigmentosa (HP:0000510)4.41671789
23Decreased electroretinogram (ERG) amplitude (HP:0000654)4.08701527
24Hyperventilation (HP:0002883)3.44395977
25Progressive visual loss (HP:0000529)3.31403805
26Fair hair (HP:0002286)3.24894829
27Retinal atrophy (HP:0001105)3.19987624
28Generalized hypopigmentation of hair (HP:0011358)3.11525740
29Widely spaced teeth (HP:0000687)3.09751479
30Nephronophthisis (HP:0000090)3.04014584
31Large for gestational age (HP:0001520)3.03999391
32Hypoplastic ischia (HP:0003175)2.99406919
33Abnormality of the renal medulla (HP:0100957)2.88661947
34Subcapsular cataract (HP:0000523)2.82827657
35Clumsiness (HP:0002312)2.74746655
36Congenital sensorineural hearing impairment (HP:0008527)2.71510294
37Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.70622608
38Thyroiditis (HP:0100646)2.67749097
39Protruding tongue (HP:0010808)2.67052402
40Optic disc pallor (HP:0000543)2.53685571
41Wide nasal bridge (HP:0000431)2.53368150
42Abnormality of the renal cortex (HP:0011035)2.48752211
43Tubular atrophy (HP:0000092)2.45854521
44Blue irides (HP:0000635)2.43457063
45Abnormality of the nasal septum (HP:0000419)2.42592464
46Acute lymphatic leukemia (HP:0006721)2.37983669
47Abnormality of the ischium (HP:0003174)2.37544302
48Hypothermia (HP:0002045)2.28359305
49Abnormality of B cell number (HP:0010975)2.23683419
50Abnormality of the wing of the ilium (HP:0011867)2.17308316
51Abnormal drinking behavior (HP:0030082)2.11153345
52Polydipsia (HP:0001959)2.11153345
53Gait imbalance (HP:0002141)2.08351153
54Congenital primary aphakia (HP:0007707)2.06173363
55Flared iliac wings (HP:0002869)2.05256940
56Bile duct proliferation (HP:0001408)2.03235695
57Abnormal biliary tract physiology (HP:0012439)2.03235695
58Abnormality of the sella turcica (HP:0002679)2.02981893
59Congenital stationary night blindness (HP:0007642)14.8727332
60Bony spicule pigmentary retinopathy (HP:0007737)12.2759084
61Absent rod-and cone-mediated responses on ERG (HP:0007688)10.5149239
62Abnormal rod and cone electroretinograms (HP:0008323)10.1926318
63J-shaped sella turcica (HP:0002680)1.95780133
64Stomach cancer (HP:0012126)1.94244440
65Hematochezia (HP:0002573)1.93186613
66Acute myeloid leukemia (HP:0004808)1.92812213
67Duplicated collecting system (HP:0000081)1.92708733
68Hypoproteinemia (HP:0003075)1.92136551
69Hypoplastic iliac wings (HP:0002866)1.90559448
70B lymphocytopenia (HP:0010976)1.83173443
71Nephrogenic diabetes insipidus (HP:0009806)1.81005827
72Absent speech (HP:0001344)1.80903106
73Thyroid-stimulating hormone excess (HP:0002925)1.79858803
74Prominent nose (HP:0000448)1.79711171
75Hypoplasia of the thymus (HP:0000778)1.76246846
76Stage 5 chronic kidney disease (HP:0003774)1.76112021
77Postaxial foot polydactyly (HP:0001830)1.75750199
78Neoplasm of the adrenal cortex (HP:0100641)1.75009188
79Highly arched eyebrow (HP:0002553)1.74461936
80Male pseudohermaphroditism (HP:0000037)1.72824447
81Truncal obesity (HP:0001956)1.72530450
82Tapered finger (HP:0001182)1.72506736
83Autoimmune hemolytic anemia (HP:0001890)1.72200988
84Abnormality of the renal collecting system (HP:0004742)1.72161099
85Medial flaring of the eyebrow (HP:0010747)1.71942153
86Macroglossia (HP:0000158)1.71774417
87Abnormality of T cell number (HP:0011839)1.67577257
88Clubbing of toes (HP:0100760)1.67359075
89Chronic diarrhea (HP:0002028)1.65890415
90Interstitial pulmonary disease (HP:0006530)1.64004448
91Ketoacidosis (HP:0001993)1.63782814
92Abnormality of chloride homeostasis (HP:0011422)1.63348125
93Bulbous nose (HP:0000414)1.62608697
94Abnormality of the vertebral endplates (HP:0005106)1.62451320
95Hyperkalemia (HP:0002153)1.61938025
96Low anterior hairline (HP:0000294)1.61329354
97Optic atrophy (HP:0000648)1.60457294
98Hypoplasia of the odontoid process (HP:0003311)1.59834564
99Abnormality of the pubic bones (HP:0003172)1.58631929
100Renal cortical cysts (HP:0000803)1.57659424
101Poor coordination (HP:0002370)1.57427425
102Neonatal respiratory distress (HP:0002643)1.57177481
103Horizontal nystagmus (HP:0000666)1.56268099
104Small hand (HP:0200055)1.55995067
105Chromsome breakage (HP:0040012)1.55955448
106Ocular albinism (HP:0001107)1.55947797
107Polar cataract (HP:0010696)1.55814082
108Polyuria (HP:0000103)1.55623370
109Tented upper lip vermilion (HP:0010804)1.55595128
110Mitral stenosis (HP:0001718)1.53670786
111Chronic sinusitis (HP:0011109)1.53236876
112Abnormal pancreas size (HP:0012094)1.51513745
113Ectopic kidney (HP:0000086)1.51444992
114Enlarged penis (HP:0000040)1.50818356
115Vaginal atresia (HP:0000148)1.41376117
116Abnormality of the fovea (HP:0000493)1.35511266
117Genital tract atresia (HP:0001827)1.35099296
118True hermaphroditism (HP:0010459)1.32902843
119Aplasia/Hypoplasia of the fovea (HP:0008060)1.28130078
120Hypoplasia of the fovea (HP:0007750)1.28130078
121Severe Myopia (HP:0011003)1.27676439
122Dysdiadochokinesis (HP:0002075)1.27120246
123Pancreatic fibrosis (HP:0100732)1.26551068
124Retinal detachment (HP:0000541)1.23698888
125Epileptic encephalopathy (HP:0200134)1.20093675
126Aplasia/Hypoplasia of the lens (HP:0008063)1.19354023
127Cystic liver disease (HP:0006706)1.06836944
128Febrile seizures (HP:0002373)1.06220282
129Visual hallucinations (HP:0002367)1.04552484
130Astigmatism (HP:0000483)1.04376802
131Pancreatic cysts (HP:0001737)1.01331500
132Aplasia/Hypoplasia of the macula (HP:0008059)0.98050432
133Recurrent sinusitis (HP:0011108)0.97596281
134Truncal ataxia (HP:0002078)0.94039158
135Progressive cerebellar ataxia (HP:0002073)0.92644581
136Chorioretinal coloboma (HP:0000567)0.91821256
137Aplasia/Hypoplasia affecting the retina (HP:0008061)0.90986388
138Hypermetropia (HP:0000540)0.88226747
139Aplasia/Hypoplasia of the tongue (HP:0010295)0.86950071
140Left ventricular hypertrophy (HP:0001712)0.85062870
141Specific learning disability (HP:0001328)0.84782794
142Broad foot (HP:0001769)0.82402765
143Prolonged QT interval (HP:0001657)0.82134612
144Furrowed tongue (HP:0000221)0.79236898
145Sclerocornea (HP:0000647)0.79181761
146Genetic anticipation (HP:0003743)0.78808932
147Asthma (HP:0002099)0.77639836
148Decreased testicular size (HP:0008734)0.76446018
149Cerebellar dysplasia (HP:0007033)0.72492577
150Macroorchidism (HP:0000053)0.70763272
151Abnormality of dental color (HP:0011073)0.68838868
152Corneal dystrophy (HP:0001131)0.68300972
153Abnormality of the fingertips (HP:0001211)0.68012963
154Molar tooth sign on MRI (HP:0002419)0.67667870
155Abnormality of midbrain morphology (HP:0002418)0.67667870
156Lymphopenia (HP:0001888)0.66220485
157Abnormal EKG (HP:0003115)0.65785166
158Syncope (HP:0001279)0.63275860
159Anencephaly (HP:0002323)0.61894421
160Broad-based gait (HP:0002136)0.61874102
161Aqueductal stenosis (HP:0002410)0.60771285
162Chronic hepatic failure (HP:0100626)0.60158343
163Abnormality of cells of the lymphoid lineage (HP:0012140)0.60111528
164Generalized myoclonic seizures (HP:0002123)0.59534506
165Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.58553746
166Postaxial hand polydactyly (HP:0001162)0.57444486
167Partial agenesis of the corpus callosum (HP:0001338)0.57425150
168Congenital hepatic fibrosis (HP:0002612)0.57253415
169Short foot (HP:0001773)0.56777204
170Dental crowding (HP:0000678)0.56102488
171Albinism (HP:0001022)0.56058278
172Gaze-evoked nystagmus (HP:0000640)0.55901052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.41687593
2PINK12.99709319
3ACVR1B2.89100992
4BMPR1B2.67478888
5MST42.64073117
6IRAK22.19340300
7TRPM72.15406138
8GRK112.3080866
9SIK21.95564963
10FGFR31.77909244
11FGFR21.77208222
12MAP3K101.76142312
13NLK1.74149962
14STK391.70189348
15CDK121.69952666
16CAMK1G1.68317209
17ADRBK21.63686333
18STK31.45302468
19NUAK11.44168014
20CAMK1D1.41914106
21TXK1.40729238
22PAK61.38720470
23BRD41.38481987
24ADRBK11.37884230
25FER1.37529305
26MKNK21.35371924
27TAOK31.32715587
28MAP4K21.32053615
29MAPK121.31080429
30HIPK21.29718884
31MAPK71.28895069
32STK381.24078538
33IRAK11.23905483
34CHUK1.22615678
35OXSR11.22314912
36MAP3K41.21765441
37TNIK1.19597048
38PNCK1.18660425
39PIK3CG1.17814124
40ZAK1.14845419
41PIK3CA1.14655656
42CSNK1D1.11695038
43PRKD31.11176879
44TEC1.09357835
45MAPKAPK31.06111915
46IKBKB1.05548529
47MARK11.05131050
48MAP3K141.03013019
49MELK1.02630432
50TIE11.02027620
51PRKCH1.01224829
52INSRR0.97282276
53ERBB20.96888215
54NEK10.92985870
55WNK10.91492156
56ICK0.90917181
57EEF2K0.90910328
58SGK4940.90206518
59SGK2230.90206518
60PRKCZ0.89745190
61CAMKK10.89292465
62RPS6KA40.88634174
63MAP3K20.86688371
64MAP3K30.86097787
65SGK20.85688523
66MET0.84192968
67GRK50.81826215
68SGK30.81158396
69TGFBR10.80264658
70PDGFRB0.79691741
71PTK2B0.78918238
72PRKCB0.76135619
73PRKAA10.72269593
74DYRK1A0.70946042
75MKNK10.70560324
76STK38L0.70241853
77TTK0.69892665
78PLK20.69596219
79EIF2AK30.67888793
80IKBKE0.67887429
81TGFBR20.67344501
82PRKAA20.65860599
83MAP2K60.65647255
84CAMK2D0.65319966
85KIT0.65259757
86AKT30.64743047
87MAPK110.62995166
88MAP2K10.62708727
89BMPR20.62673349
90FES0.62660671
91NEK90.61494861
92PRKACG0.60623359
93RPS6KA30.59576154
94MAPK150.59150793
95DYRK1B0.56269900
96NEK20.55529119
97PRKCI0.55378104
98CDK60.54828180
99PRKD20.52635198
100STK40.51371619
101LATS10.51270550
102CDK50.51040150
103FRK0.50606415
104FGFR40.50322979
105MAP3K70.49801411
106PRKDC0.49584314
107PRKCQ0.49176834
108TNK20.49005518
109SGK10.48695306
110CAMK10.48336571
111PHKG20.47118527
112PHKG10.47118527
113PRKCE0.47042798
114SIK10.46516354
115RPS6KB20.46226266
116TYK20.46167193
117GSK3B0.46105124
118SCYL20.45533355
119CDK90.44584214
120CSF1R0.43879797
121MAP3K130.43060538
122CAMK40.42630183
123MAPK100.42151033
124MAPK140.41722898
125MINK10.41264710
126PLK30.40732549
127ITK0.40669606
128PKN10.40614847
129MAP2K70.40426670
130AKT20.40237367
131MAP2K40.39384408
132STK110.39279787
133MAP2K30.38935493
134CDK40.38162213
135NEK60.37890068
136MAPK90.37268249
137MTOR0.36676241
138MYLK0.36400415
139CDK10.34293019
140PTK60.33921438
141CDK30.33448141
142FLT30.33361369
143CDK70.33249961
144NTRK30.33143024
145MAPK10.32957183
146STK100.32769686
147PRKCG0.32655564
148JAK30.31847209
149ALK0.31844259
150TRIB30.31820892
151PRKACA0.28834554
152PRKCA0.28402299
153CAMK2A0.27902622
154PDK20.27591064
155CDC42BPA0.27554245
156CSNK1E0.25197882
157MAP3K90.24565422
158MAPK80.23686641
159RPS6KB10.22646907
160ATM0.21301906
161CHEK20.20775789
162RIPK10.20754757
163WNK40.19971741
164SRC0.19785117
165PAK30.19248901
166PRKD10.18485170
167CHEK10.17724448
168JAK10.17678929
169PDK10.17381682

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004503.24521993
2Homologous recombination_Homo sapiens_hsa034402.11739328
3Non-homologous end-joining_Homo sapiens_hsa034502.08796345
4Ether lipid metabolism_Homo sapiens_hsa005652.01118004
5* Phototransduction_Homo sapiens_hsa0474415.7934045
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.69739141
7Fanconi anemia pathway_Homo sapiens_hsa034601.69226798
8Dorso-ventral axis formation_Homo sapiens_hsa043201.68782978
9Synaptic vesicle cycle_Homo sapiens_hsa047211.64909916
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64044957
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58121217
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53376597
13Olfactory transduction_Homo sapiens_hsa047401.49395623
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49103017
15Butanoate metabolism_Homo sapiens_hsa006501.44438124
16One carbon pool by folate_Homo sapiens_hsa006701.24513298
17GABAergic synapse_Homo sapiens_hsa047271.24017513
18Nitrogen metabolism_Homo sapiens_hsa009101.23504539
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15570481
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.13573269
21Basal transcription factors_Homo sapiens_hsa030221.09959166
22Sphingolipid metabolism_Homo sapiens_hsa006001.08828465
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.08656529
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.08077438
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05322218
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04818792
27Primary immunodeficiency_Homo sapiens_hsa053401.03181367
28FoxO signaling pathway_Homo sapiens_hsa040681.02240363
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.01066101
30Steroid hormone biosynthesis_Homo sapiens_hsa001400.96676115
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95024623
32Cholinergic synapse_Homo sapiens_hsa047250.93764947
33Retinol metabolism_Homo sapiens_hsa008300.92558919
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88680600
35Prostate cancer_Homo sapiens_hsa052150.86362151
36Complement and coagulation cascades_Homo sapiens_hsa046100.86271481
37Glutamatergic synapse_Homo sapiens_hsa047240.83933414
38Circadian entrainment_Homo sapiens_hsa047130.83907467
39Other glycan degradation_Homo sapiens_hsa005110.83022131
40Morphine addiction_Homo sapiens_hsa050320.82771245
41Ovarian steroidogenesis_Homo sapiens_hsa049130.82007527
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81605811
43Circadian rhythm_Homo sapiens_hsa047100.81025385
44TNF signaling pathway_Homo sapiens_hsa046680.78803965
45Dopaminergic synapse_Homo sapiens_hsa047280.77453765
46Propanoate metabolism_Homo sapiens_hsa006400.76807567
47Chemical carcinogenesis_Homo sapiens_hsa052040.76693484
48Peroxisome_Homo sapiens_hsa041460.74755731
49T cell receptor signaling pathway_Homo sapiens_hsa046600.73871899
50ABC transporters_Homo sapiens_hsa020100.73565895
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71061890
52B cell receptor signaling pathway_Homo sapiens_hsa046620.71038839
53N-Glycan biosynthesis_Homo sapiens_hsa005100.70846394
54Tryptophan metabolism_Homo sapiens_hsa003800.69634544
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69498695
56Taste transduction_Homo sapiens_hsa047420.69354373
57Vitamin digestion and absorption_Homo sapiens_hsa049770.68308004
58Platelet activation_Homo sapiens_hsa046110.65086488
59RNA polymerase_Homo sapiens_hsa030200.64344956
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63150581
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62266715
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61698682
63Serotonergic synapse_Homo sapiens_hsa047260.61498154
64Small cell lung cancer_Homo sapiens_hsa052220.61315242
65Insulin secretion_Homo sapiens_hsa049110.60214572
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59338984
67ECM-receptor interaction_Homo sapiens_hsa045120.57215268
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56983209
69Arachidonic acid metabolism_Homo sapiens_hsa005900.56226597
70Asthma_Homo sapiens_hsa053100.55342682
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54237204
72Nicotine addiction_Homo sapiens_hsa050330.53288210
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52734315
74Type I diabetes mellitus_Homo sapiens_hsa049400.52284432
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51776592
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51761590
77Regulation of autophagy_Homo sapiens_hsa041400.51268740
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51092310
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50871548
80Hematopoietic cell lineage_Homo sapiens_hsa046400.50408743
81Oxytocin signaling pathway_Homo sapiens_hsa049210.49576002
82Prolactin signaling pathway_Homo sapiens_hsa049170.49078145
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.48204132
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48099677
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47395460
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46784588
87Melanoma_Homo sapiens_hsa052180.46666972
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46286091
89Allograft rejection_Homo sapiens_hsa053300.45709210
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44441721
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43771096
92Measles_Homo sapiens_hsa051620.43351809
93Autoimmune thyroid disease_Homo sapiens_hsa053200.41588763
94MicroRNAs in cancer_Homo sapiens_hsa052060.41418068
95Acute myeloid leukemia_Homo sapiens_hsa052210.40841109
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39750701
97Dilated cardiomyopathy_Homo sapiens_hsa054140.38695118
98Fructose and mannose metabolism_Homo sapiens_hsa000510.38589126
99Lysosome_Homo sapiens_hsa041420.38316406
100Renin secretion_Homo sapiens_hsa049240.38151594
101RNA degradation_Homo sapiens_hsa030180.38121962
102Inositol phosphate metabolism_Homo sapiens_hsa005620.37816857
103cAMP signaling pathway_Homo sapiens_hsa040240.37229004
104African trypanosomiasis_Homo sapiens_hsa051430.37122672
105Salivary secretion_Homo sapiens_hsa049700.36736905
106Arginine biosynthesis_Homo sapiens_hsa002200.36611641
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36398256
108Purine metabolism_Homo sapiens_hsa002300.36054950
109TGF-beta signaling pathway_Homo sapiens_hsa043500.35165824
110Glycerolipid metabolism_Homo sapiens_hsa005610.34463208
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34174155
112Cardiac muscle contraction_Homo sapiens_hsa042600.33665862
113Gastric acid secretion_Homo sapiens_hsa049710.33002866
114Caffeine metabolism_Homo sapiens_hsa002320.31981488
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31838264
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30741827
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.30409480
118mTOR signaling pathway_Homo sapiens_hsa041500.30215216
119Cocaine addiction_Homo sapiens_hsa050300.30187189
120Long-term potentiation_Homo sapiens_hsa047200.29978635
121Lysine degradation_Homo sapiens_hsa003100.28020515
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27175910
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26922279
124Type II diabetes mellitus_Homo sapiens_hsa049300.25011976
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.24163621
126Glucagon signaling pathway_Homo sapiens_hsa049220.21862697
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.21106756
128Amphetamine addiction_Homo sapiens_hsa050310.21025410
129Bile secretion_Homo sapiens_hsa049760.20648898
130Chemokine signaling pathway_Homo sapiens_hsa040620.20613513
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18640170
132GnRH signaling pathway_Homo sapiens_hsa049120.18010300
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17677277
134HIF-1 signaling pathway_Homo sapiens_hsa040660.17201623
135Calcium signaling pathway_Homo sapiens_hsa040200.17049977
136Alcoholism_Homo sapiens_hsa050340.16944223
137Fatty acid elongation_Homo sapiens_hsa000620.16943979
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16913726
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.16353923
140AMPK signaling pathway_Homo sapiens_hsa041520.16310522
141Pancreatic secretion_Homo sapiens_hsa049720.15074276
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14297846
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14217144
144Biosynthesis of amino acids_Homo sapiens_hsa012300.13666438
145Ras signaling pathway_Homo sapiens_hsa040140.13459496
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13346820
147MAPK signaling pathway_Homo sapiens_hsa040100.12206394
148Thyroid hormone synthesis_Homo sapiens_hsa049180.11912900
149Tight junction_Homo sapiens_hsa045300.11845791
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.11036229
151Mineral absorption_Homo sapiens_hsa049780.10083785
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10030510
153Galactose metabolism_Homo sapiens_hsa000520.10009182
154Glioma_Homo sapiens_hsa052140.09981452
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.09231307
156Insulin resistance_Homo sapiens_hsa049310.08387750
157Choline metabolism in cancer_Homo sapiens_hsa052310.07033916
158alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.06807424
159Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06539239
160Maturity onset diabetes of the young_Homo sapiens_hsa049500.05899348
161Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05682443
162Linoleic acid metabolism_Homo sapiens_hsa005910.05443821
163mRNA surveillance pathway_Homo sapiens_hsa030150.05091497
164Collecting duct acid secretion_Homo sapiens_hsa049660.04934904
165Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.04889556
166Melanogenesis_Homo sapiens_hsa049160.04218126
167Endocytosis_Homo sapiens_hsa041440.03942766
168ErbB signaling pathway_Homo sapiens_hsa040120.03855553
169Fat digestion and absorption_Homo sapiens_hsa049750.03765927
170Hippo signaling pathway_Homo sapiens_hsa043900.03403629
171Wnt signaling pathway_Homo sapiens_hsa043100.02451005
172Renal cell carcinoma_Homo sapiens_hsa052110.02310053

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