SLC24A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.63855712
2synaptic vesicle maturation (GO:0016188)5.45494084
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.39407611
4neuronal action potential propagation (GO:0019227)5.37178589
5locomotory exploration behavior (GO:0035641)5.33154851
6synaptic vesicle exocytosis (GO:0016079)5.32722888
7glutamate secretion (GO:0014047)5.07256080
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.03358697
9central nervous system myelination (GO:0022010)4.97633606
10axon ensheathment in central nervous system (GO:0032291)4.97633606
11vocalization behavior (GO:0071625)4.97108557
12regulation of synaptic vesicle exocytosis (GO:2000300)4.92241153
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.83925400
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.82734374
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.80006854
16regulation of glutamate receptor signaling pathway (GO:1900449)4.53609663
17regulation of synaptic vesicle transport (GO:1902803)4.40193132
18regulation of neuronal synaptic plasticity (GO:0048168)4.37079879
19synaptic transmission, glutamatergic (GO:0035249)4.36390216
20neuron cell-cell adhesion (GO:0007158)4.32538372
21protein localization to synapse (GO:0035418)4.31618697
22glutamate receptor signaling pathway (GO:0007215)4.29367707
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.29052481
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.28421531
25neuron-neuron synaptic transmission (GO:0007270)4.25321974
26neurotransmitter secretion (GO:0007269)4.18218835
27exploration behavior (GO:0035640)4.07241137
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.02242505
29negative regulation of dendrite development (GO:2000171)3.99313988
30gamma-aminobutyric acid transport (GO:0015812)3.90299540
31regulation of excitatory postsynaptic membrane potential (GO:0060079)3.87840394
32C4-dicarboxylate transport (GO:0015740)3.86093021
33regulation of synapse structural plasticity (GO:0051823)3.85903381
34long-term memory (GO:0007616)3.85185868
35neurotransmitter-gated ion channel clustering (GO:0072578)3.84093420
36cellular potassium ion homeostasis (GO:0030007)3.82459552
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.79320871
38potassium ion homeostasis (GO:0055075)3.77459655
39potassium ion import (GO:0010107)3.76755625
40positive regulation of membrane potential (GO:0045838)3.71588407
41regulation of postsynaptic membrane potential (GO:0060078)3.65864035
42* regulation of synaptic plasticity (GO:0048167)3.64717977
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62462669
44transmission of nerve impulse (GO:0019226)3.62199648
45positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.62116784
46cellular sodium ion homeostasis (GO:0006883)3.61662968
47dendritic spine morphogenesis (GO:0060997)3.56918060
48serotonin metabolic process (GO:0042428)3.55499307
49neuromuscular process controlling posture (GO:0050884)3.52811375
50neurotransmitter transport (GO:0006836)3.47859340
51regulation of dendritic spine morphogenesis (GO:0061001)3.43679474
52cerebellar Purkinje cell differentiation (GO:0021702)3.43534486
53* long-term synaptic potentiation (GO:0060291)3.40731441
54presynaptic membrane assembly (GO:0097105)3.39995488
55L-amino acid import (GO:0043092)3.39567634
56negative regulation of dendrite morphogenesis (GO:0050774)3.37054026
57neuron recognition (GO:0008038)3.36711811
58regulation of neurotransmitter secretion (GO:0046928)3.34863343
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.33335686
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.33226026
61presynaptic membrane organization (GO:0097090)3.32171828
62positive regulation of potassium ion transmembrane transport (GO:1901381)3.31418216
63sodium ion export (GO:0071436)3.31381240
64neuromuscular process controlling balance (GO:0050885)3.30520667
65amino acid import (GO:0043090)3.29145674
66membrane depolarization during action potential (GO:0086010)3.28671291
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26843286
68layer formation in cerebral cortex (GO:0021819)3.26679841
69activation of protein kinase A activity (GO:0034199)3.25551831
70positive regulation of dendritic spine development (GO:0060999)3.24451066
71cell differentiation in hindbrain (GO:0021533)3.24325496
72synaptic vesicle endocytosis (GO:0048488)3.24120864
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.23916202
74membrane depolarization (GO:0051899)3.23902886
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22102954
76proline transport (GO:0015824)3.21959594
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.21913999
78regulation of neurotransmitter levels (GO:0001505)3.20264801
79regulation of synapse maturation (GO:0090128)3.19997265
80acidic amino acid transport (GO:0015800)3.19969227
81primary amino compound metabolic process (GO:1901160)3.19622105
82neuronal ion channel clustering (GO:0045161)3.19134882
83detection of calcium ion (GO:0005513)3.18521945
84adult walking behavior (GO:0007628)3.17419130
85regulation of neurotransmitter transport (GO:0051588)3.16226352
86neurotransmitter uptake (GO:0001504)3.14506235
87positive regulation of synapse maturation (GO:0090129)3.13308291
88membrane hyperpolarization (GO:0060081)3.11756685
89regulation of vesicle fusion (GO:0031338)3.11650742
90axonal fasciculation (GO:0007413)3.11377069
91positive regulation of neurotransmitter transport (GO:0051590)3.10775699
92response to histamine (GO:0034776)3.09842812
93innervation (GO:0060384)3.06973894
94glycine transport (GO:0015816)3.05798917
95vesicle transport along microtubule (GO:0047496)3.04958224
96positive regulation of dendritic spine morphogenesis (GO:0061003)3.04881454
97cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04549189
98regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04084544
99behavioral response to cocaine (GO:0048148)3.04058914
100positive regulation of synaptic transmission, GABAergic (GO:0032230)3.04034381
101regulation of voltage-gated calcium channel activity (GO:1901385)3.02378184
102auditory behavior (GO:0031223)3.01843894
103G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.01838460
104synaptic transmission (GO:0007268)3.01418011
105neuromuscular process (GO:0050905)3.01268675
106cerebellar granule cell differentiation (GO:0021707)3.00872828
107behavioral defense response (GO:0002209)3.00739895
108behavioral fear response (GO:0001662)3.00739895
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00568202
110positive regulation of neurotransmitter secretion (GO:0001956)3.00207514
111* regulation of synaptic transmission (GO:0050804)2.98983150
112chemosensory behavior (GO:0007635)2.97599027
113* learning (GO:0007612)2.97146967
114glycosphingolipid biosynthetic process (GO:0006688)2.96992379
115multicellular organismal signaling (GO:0035637)2.95460962
116cell communication by electrical coupling (GO:0010644)2.94751566
117regulation of dendritic spine development (GO:0060998)2.93756695
118startle response (GO:0001964)2.92739929
119cellular potassium ion transport (GO:0071804)2.92406569
120potassium ion transmembrane transport (GO:0071805)2.92406569
121response to auditory stimulus (GO:0010996)2.90973727
122striatum development (GO:0021756)2.90737331
123regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90604386
124postsynaptic membrane organization (GO:0001941)2.90016096
125L-glutamate transport (GO:0015813)2.89394461
126prepulse inhibition (GO:0060134)2.88679800
127central nervous system projection neuron axonogenesis (GO:0021952)2.86550076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.97232406
2GBX2_23144817_ChIP-Seq_PC3_Human3.89607880
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11076018
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04780775
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97582277
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.68516392
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.64170187
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61759413
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61759413
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57034569
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54560888
12DROSHA_22980978_ChIP-Seq_HELA_Human2.51679135
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49801672
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48401890
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43248150
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37066364
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.34276848
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.16898795
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16187675
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.15025389
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.10816943
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.10303799
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00959735
24TAF15_26573619_Chip-Seq_HEK293_Human1.98469094
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87928375
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82919131
27AR_21572438_ChIP-Seq_LNCaP_Human1.81393278
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80592362
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75236588
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.72702725
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72165299
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63742627
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62630653
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61882514
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55103250
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52420250
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47020447
38* P300_19829295_ChIP-Seq_ESCs_Human1.43764465
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42099327
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40762377
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38306009
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.38153881
43* SMAD3_21741376_ChIP-Seq_EPCs_Human1.36834101
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36357567
45STAT3_23295773_ChIP-Seq_U87_Human1.34997364
46* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34605923
47* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33502095
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.31939862
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29221780
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28391246
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27617807
52AR_25329375_ChIP-Seq_VCAP_Human1.26422369
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.24177384
54ZNF274_21170338_ChIP-Seq_K562_Hela1.22926139
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21870466
56* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20315963
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.18958602
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18301212
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.18030346
60AR_19668381_ChIP-Seq_PC3_Human1.17609505
61* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17137861
62* TCF4_23295773_ChIP-Seq_U87_Human1.16844398
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.16769155
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16683889
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16023848
66* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15902516
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15296415
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15296415
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14915999
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14566158
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13043454
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11768473
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11610353
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.11066266
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.09966382
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09952557
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09927466
78IGF1R_20145208_ChIP-Seq_DFB_Human1.07518201
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06671142
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06366672
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06276435
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.06195983
83AHR_22903824_ChIP-Seq_MCF-7_Human1.05650147
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05284872
85EWS_26573619_Chip-Seq_HEK293_Human1.04905490
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.04421752
87KDM2B_26808549_Chip-Seq_REH_Human1.04012206
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03054729
89RUNX2_22187159_ChIP-Seq_PCA_Human1.01645363
90JUN_21703547_ChIP-Seq_K562_Human1.01563961
91P53_22387025_ChIP-Seq_ESCs_Mouse1.01312568
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01230423
93FUS_26573619_Chip-Seq_HEK293_Human1.01138252
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01024594
95TP53_16413492_ChIP-PET_HCT116_Human1.00929098
96CBP_20019798_ChIP-Seq_JUKART_Human1.00387134
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00387134
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99935371
99RNF2_27304074_Chip-Seq_NSC_Mouse0.99418417
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99179110
101TCF4_22108803_ChIP-Seq_LS180_Human0.98640281
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98560857
103* RING1B_27294783_Chip-Seq_NPCs_Mouse0.97116450
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96671295
105VDR_22108803_ChIP-Seq_LS180_Human0.96316963
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93449113
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93366611
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.92845393
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.92623988
110ER_23166858_ChIP-Seq_MCF-7_Human0.92604404
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92439562
112* NANOG_18555785_Chip-Seq_ESCs_Mouse0.91276922
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.90626661
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90054231
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89674853
116RXR_22108803_ChIP-Seq_LS180_Human0.89151296
117KDM2B_26808549_Chip-Seq_K562_Human0.87021634
118BCAT_22108803_ChIP-Seq_LS180_Human0.85251342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.57419461
2MP0003880_abnormal_central_pattern5.11731804
3* MP0003635_abnormal_synaptic_transmissio4.14196342
4MP0004270_analgesia4.04307391
5MP0009745_abnormal_behavioral_response3.49696538
6MP0009046_muscle_twitch3.37611965
7MP0002064_seizures3.36839809
8* MP0002063_abnormal_learning/memory/cond3.26529564
9MP0001968_abnormal_touch/_nociception2.95344489
10MP0002272_abnormal_nervous_system2.94918431
11MP0002822_catalepsy2.94831076
12MP0002572_abnormal_emotion/affect_behav2.82468105
13MP0001486_abnormal_startle_reflex2.75386713
14MP0002734_abnormal_mechanical_nocicepti2.63880605
15MP0005423_abnormal_somatic_nervous2.41084861
16MP0002736_abnormal_nociception_after2.34741234
17MP0001501_abnormal_sleep_pattern2.34316202
18MP0002735_abnormal_chemical_nociception2.18098532
19MP0008569_lethality_at_weaning2.05669897
20MP0002067_abnormal_sensory_capabilities2.05203719
21MP0001440_abnormal_grooming_behavior2.02112551
22MP0009780_abnormal_chondrocyte_physiolo1.96304333
23MP0001970_abnormal_pain_threshold1.95625819
24MP0002733_abnormal_thermal_nociception1.93274841
25MP0003329_amyloid_beta_deposits1.89163955
26MP0005646_abnormal_pituitary_gland1.84206873
27MP0005386_behavior/neurological_phenoty1.72082339
28MP0004924_abnormal_behavior1.72082339
29MP0002909_abnormal_adrenal_gland1.67703002
30MP0004811_abnormal_neuron_physiology1.65842260
31MP0002184_abnormal_innervation1.64538442
32MP0008877_abnormal_DNA_methylation1.63338921
33MP0003879_abnormal_hair_cell1.61619025
34MP0002557_abnormal_social/conspecific_i1.60235880
35MP0000778_abnormal_nervous_system1.60000495
36MP0001984_abnormal_olfaction1.53377993
37MP0000955_abnormal_spinal_cord1.53088042
38MP0003633_abnormal_nervous_system1.51529742
39MP0001529_abnormal_vocalization1.50440752
40MP0004885_abnormal_endolymph1.47462403
41MP0002066_abnormal_motor_capabilities/c1.46570147
42MP0004858_abnormal_nervous_system1.45774613
43MP0002882_abnormal_neuron_morphology1.40979024
44MP0004142_abnormal_muscle_tone1.40695033
45MP0000920_abnormal_myelination1.38088847
46MP0003787_abnormal_imprinting1.37657036
47MP0004147_increased_porphyrin_level1.34863736
48MP0001905_abnormal_dopamine_level1.32499231
49MP0006276_abnormal_autonomic_nervous1.29907610
50MP0003631_nervous_system_phenotype1.27948534
51MP0005645_abnormal_hypothalamus_physiol1.16818604
52MP0002229_neurodegeneration1.16489072
53MP0003690_abnormal_glial_cell1.15196533
54MP0001502_abnormal_circadian_rhythm1.14258966
55MP0004145_abnormal_muscle_electrophysio1.10562778
56MP0004742_abnormal_vestibular_system1.07409378
57MP0002638_abnormal_pupillary_reflex1.04619125
58MP0001188_hyperpigmentation1.02335749
59MP0002152_abnormal_brain_morphology1.02121275
60MP0004043_abnormal_pH_regulation1.00467333
61MP0001485_abnormal_pinna_reflex1.00466721
62MP0000013_abnormal_adipose_tissue0.98763980
63MP0008872_abnormal_physiological_respon0.98682237
64MP0003634_abnormal_glial_cell0.97197494
65MP0005551_abnormal_eye_electrophysiolog0.96937475
66MP0008874_decreased_physiological_sensi0.96434532
67MP0003122_maternal_imprinting0.95172011
68MP0003632_abnormal_nervous_system0.92301956
69MP0001177_atelectasis0.91655896
70MP0001963_abnormal_hearing_physiology0.91487166
71MP0001986_abnormal_taste_sensitivity0.91438207
72MP0000751_myopathy0.90682031
73MP0002069_abnormal_eating/drinking_beha0.89879730
74MP0010386_abnormal_urinary_bladder0.89361531
75MP0005409_darkened_coat_color0.86763460
76MP0003075_altered_response_to0.86207434
77MP0004085_abnormal_heartbeat0.84361199
78MP0000604_amyloidosis0.84253640
79MP0006072_abnormal_retinal_apoptosis0.82027093
80MP0005535_abnormal_body_temperature0.80724712
81MP0003283_abnormal_digestive_organ0.78750668
82MP0005253_abnormal_eye_physiology0.77344081
83MP0008875_abnormal_xenobiotic_pharmacok0.74969982
84MP0002837_dystrophic_cardiac_calcinosis0.73866181
85MP0002752_abnormal_somatic_nervous0.73015563
86MP0004215_abnormal_myocardial_fiber0.71068873
87MP0003121_genomic_imprinting0.68616581
88MP0005499_abnormal_olfactory_system0.68182994
89MP0005394_taste/olfaction_phenotype0.68182994
90MP0004484_altered_response_of0.67384144
91MP0002876_abnormal_thyroid_physiology0.65527342
92MP0004130_abnormal_muscle_cell0.65429697
93MP0001664_abnormal_digestion0.64678831
94MP0000631_abnormal_neuroendocrine_gland0.64440138
95MP0005171_absent_coat_pigmentation0.63735192
96MP0002090_abnormal_vision0.63254138
97MP0003137_abnormal_impulse_conducting0.60742832
98MP0001299_abnormal_eye_distance/0.60331167
99MP0003123_paternal_imprinting0.59770682
100MP0004510_myositis0.58095849
101MP0005187_abnormal_penis_morphology0.56171507
102MP0000026_abnormal_inner_ear0.55708858
103MP0002160_abnormal_reproductive_system0.55373162
104MP0003183_abnormal_peptide_metabolism0.55128981
105MP0000569_abnormal_digit_pigmentation0.54617153
106MP0005623_abnormal_meninges_morphology0.54533263
107MP0002082_postnatal_lethality0.54287392
108MP0010770_preweaning_lethality0.54287392
109MP0005167_abnormal_blood-brain_barrier0.53592459
110MP0001943_abnormal_respiration0.53497234
111MP0010768_mortality/aging0.52697694
112MP0010769_abnormal_survival0.50810718
113MP0006292_abnormal_olfactory_placode0.50285977
114MP0004233_abnormal_muscle_weight0.49811016
115MP0005410_abnormal_fertilization0.49536201
116MP0008961_abnormal_basal_metabolism0.49492508
117MP0003956_abnormal_body_size0.48930208
118MP0001348_abnormal_lacrimal_gland0.47996277
119MP0002751_abnormal_autonomic_nervous0.47984664
120MP0002234_abnormal_pharynx_morphology0.46844292
121MP0002102_abnormal_ear_morphology0.46617059

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.59723923
2Myokymia (HP:0002411)7.24306006
3Focal seizures (HP:0007359)5.95899581
4Atonic seizures (HP:0010819)5.38460826
5Epileptic encephalopathy (HP:0200134)5.07453106
6Febrile seizures (HP:0002373)4.91832932
7Visual hallucinations (HP:0002367)4.65010407
8Absence seizures (HP:0002121)4.53263098
9Progressive cerebellar ataxia (HP:0002073)4.39781471
10Action tremor (HP:0002345)4.34859064
11Dialeptic seizures (HP:0011146)4.20174943
12Generalized tonic-clonic seizures (HP:0002069)4.06374715
13Gaze-evoked nystagmus (HP:0000640)3.82701874
14Dysmetria (HP:0001310)3.64670957
15Supranuclear gaze palsy (HP:0000605)3.64226574
16Broad-based gait (HP:0002136)3.57112484
17Hyperventilation (HP:0002883)3.55854655
18Impaired vibration sensation in the lower limbs (HP:0002166)3.51483352
19Dysdiadochokinesis (HP:0002075)3.47071504
20Ankle clonus (HP:0011448)3.46321069
21Scanning speech (HP:0002168)3.34976828
22Truncal ataxia (HP:0002078)3.30620112
23Poor eye contact (HP:0000817)3.24586413
24Depression (HP:0000716)3.15038324
25Anxiety (HP:0000739)3.04680592
26Urinary bladder sphincter dysfunction (HP:0002839)3.04391338
27Impaired social interactions (HP:0000735)2.98176271
28Abnormal social behavior (HP:0012433)2.98176271
29Spastic gait (HP:0002064)2.92035558
30Amblyopia (HP:0000646)2.88092912
31Postural instability (HP:0002172)2.87654715
32Intention tremor (HP:0002080)2.85784213
33Neurofibrillary tangles (HP:0002185)2.84307842
34Abnormal eating behavior (HP:0100738)2.79802915
35Impaired smooth pursuit (HP:0007772)2.79663079
36Pheochromocytoma (HP:0002666)2.78743006
37Urinary urgency (HP:0000012)2.75369149
38Termporal pattern (HP:0011008)2.70800842
39Insidious onset (HP:0003587)2.70800842
40Epileptiform EEG discharges (HP:0011182)2.62796357
41Cerebral inclusion bodies (HP:0100314)2.57203019
42Hemiparesis (HP:0001269)2.56947014
43Abnormality of the corticospinal tract (HP:0002492)2.55245583
44Cerebral hypomyelination (HP:0006808)2.52115310
45Impaired vibratory sensation (HP:0002495)2.49441074
46Progressive inability to walk (HP:0002505)2.49279094
47Dysmetric saccades (HP:0000641)2.48801987
48Torticollis (HP:0000473)2.47576474
49Genetic anticipation (HP:0003743)2.47561499
50Diplopia (HP:0000651)2.46002503
51Abnormality of binocular vision (HP:0011514)2.46002503
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.45132939
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.45132939
54Drooling (HP:0002307)2.45028869
55Excessive salivation (HP:0003781)2.45028869
56Neuroendocrine neoplasm (HP:0100634)2.41678372
57Bradykinesia (HP:0002067)2.41080923
58EEG with generalized epileptiform discharges (HP:0011198)2.40098857
59Focal dystonia (HP:0004373)2.39355709
60Hemiplegia (HP:0002301)2.37604585
61Papilledema (HP:0001085)2.37410703
62Abnormality of ocular smooth pursuit (HP:0000617)2.36178191
63Absent speech (HP:0001344)2.34355534
64Stereotypic behavior (HP:0000733)2.29340589
65Generalized myoclonic seizures (HP:0002123)2.27087278
66Hypsarrhythmia (HP:0002521)2.25221046
67Status epilepticus (HP:0002133)2.25184484
68Lower limb muscle weakness (HP:0007340)2.23618367
69Mutism (HP:0002300)2.22789957
70Megalencephaly (HP:0001355)2.21973559
71Abnormality of the lower motor neuron (HP:0002366)2.18707943
72Fetal akinesia sequence (HP:0001989)2.18529342
73Ventricular fibrillation (HP:0001663)2.15999430
74Morphological abnormality of the pyramidal tract (HP:0002062)2.13312858
75Annular pancreas (HP:0001734)2.11068996
76Abnormality of saccadic eye movements (HP:0000570)2.09855841
77Craniofacial dystonia (HP:0012179)2.09356929
78Gait ataxia (HP:0002066)2.07521438
79Syncope (HP:0001279)2.07233356
80Resting tremor (HP:0002322)2.06524460
81Blue irides (HP:0000635)2.06000171
82Clonus (HP:0002169)2.01510987
83Inability to walk (HP:0002540)2.00944685
84Neuronal loss in central nervous system (HP:0002529)1.98301149
85Peripheral hypomyelination (HP:0007182)1.97644354
86Incomplete penetrance (HP:0003829)1.96708953
87Prolonged QT interval (HP:0001657)1.89589573
88Thickened helices (HP:0000391)1.86382085
89Psychosis (HP:0000709)1.84435752
90Rigidity (HP:0002063)1.82644579
91Akinesia (HP:0002304)1.80992551
92Polyphagia (HP:0002591)1.80761131
93Spastic tetraparesis (HP:0001285)1.79937768
94Amyotrophic lateral sclerosis (HP:0007354)1.79041345
95Stomach cancer (HP:0012126)1.78334514
96Onion bulb formation (HP:0003383)1.77059408
97Delusions (HP:0000746)1.76352306
98Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75658306
99Increased circulating renin level (HP:0000848)1.75139493
100Postural tremor (HP:0002174)1.75068257
101Abnormality of salivation (HP:0100755)1.74843883
102Specific learning disability (HP:0001328)1.74623800
103Bundle branch block (HP:0011710)1.73918258
104Clumsiness (HP:0002312)1.73423156
105Limb dystonia (HP:0002451)1.73182836
106Retinal dysplasia (HP:0007973)1.72853384
107Neoplasm of the peripheral nervous system (HP:0100007)1.72234948
108Abnormal EKG (HP:0003115)1.71816731
109Sleep apnea (HP:0010535)1.71494861
110Congenital stationary night blindness (HP:0007642)1.71022253
111Hamartoma of the eye (HP:0010568)1.70887832
112Gait imbalance (HP:0002141)1.68239421
113Protruding tongue (HP:0010808)1.67503478
114Horizontal nystagmus (HP:0000666)1.65398112
115Spastic tetraplegia (HP:0002510)1.64273775
116CNS hypomyelination (HP:0003429)1.63763519
117Abolished electroretinogram (ERG) (HP:0000550)1.62462873
118Tetraplegia (HP:0002445)1.62061787
119Nephronophthisis (HP:0000090)1.57254262
120Inappropriate behavior (HP:0000719)1.57246691
121Metabolic alkalosis (HP:0200114)1.55632350

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.74566772
2NTRK34.60647611
3MAP3K93.30859848
4FRK2.95245693
5MAP3K42.91289943
6RIPK42.53258568
7MINK12.49974389
8MAP2K72.48928736
9DAPK22.37470900
10PAK62.15250991
11CASK2.12397920
12PRKD32.09837264
13KSR22.02228720
14CDK192.01333294
15NTRK12.00208854
16MAP3K121.91201332
17MAP2K41.83209700
18MARK11.81262771
19CAMKK11.77930560
20PRPF4B1.76941187
21NTRK21.71692781
22TNIK1.67382149
23OXSR11.66236009
24DAPK11.62491254
25CDK51.54889622
26ARAF1.40280580
27CAMKK21.36008544
28PNCK1.34492211
29KSR11.32531183
30PLK21.31478125
31MAP3K21.26434690
32SGK2231.23834768
33SGK4941.23834768
34CAMK2B1.23229274
35STK381.22751628
36PRKCG1.21557037
37STK391.19046372
38FES1.18579752
39UHMK11.18488492
40GRK51.18408198
41BMPR21.18267509
42MAP3K131.17465641
43CAMK2A1.11551480
44MAPK131.09806553
45WNK11.01552855
46PKN10.98626531
47TYRO30.94860905
48SGK20.91058522
49PTK2B0.90402612
50PINK10.89578277
51PRKCH0.87851270
52CAMK10.87733386
53CDK180.87349780
54CDK150.85222235
55CDK140.83811081
56PDK10.82921078
57PDPK10.82392396
58STK110.80946080
59GRK10.80835875
60SIK20.80025540
61CSNK1A1L0.79656589
62CSNK1G30.79552333
63ADRBK20.79497102
64MAP4K20.78520646
65NEK60.78094653
66SGK30.76327697
67CAMK2D0.75817573
68RAF10.75771524
69RET0.74857388
70AKT30.74582683
71SGK10.73777395
72CDK11A0.72938414
73PAK30.69922346
74MAP3K10.67793882
75PHKG10.65964266
76PHKG20.65964266
77CAMK2G0.65097662
78NME10.62620194
79CSNK1G10.61994182
80CSNK1D0.61863850
81MAPKAPK50.61394549
82PRKG10.61129740
83MARK20.60963171
84TNK20.60608678
85WNK40.59074820
86PRKCE0.58952609
87TAOK10.57669674
88LMTK20.57202659
89CSNK1G20.56418064
90PRKCA0.54277079
91DYRK1A0.51312306
92PRKACA0.50804318
93ROCK20.50425583
94BCR0.50358870
95INSRR0.50112439
96FGFR20.48863072
97BRAF0.48726272
98FGR0.47540284
99FYN0.46865596
100PRKCB0.46723149
101* RPS6KA30.46663397
102BMPR1B0.45584737
103CDC42BPA0.45552293
104MAPK100.45423987
105ALK0.44326612
106* CSNK1A10.42872296
107MAP3K70.41549571
108CCNB10.40397361
109MAP2K10.39733549
110LIMK10.38604283
111PRKCZ0.38247943
112CAMK40.37390541
113MAPK120.37248661
114CAMK1G0.37154049
115TAOK30.36078631
116DAPK30.35950594
117MAPK80.35752854
118FER0.35700147
119LATS20.34814569
120WNK30.34494479
121DYRK20.32396195

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.76266142
2Synaptic vesicle cycle_Homo sapiens_hsa047213.21842833
3Long-term potentiation_Homo sapiens_hsa047202.80846629
4Olfactory transduction_Homo sapiens_hsa047402.75852195
5Circadian entrainment_Homo sapiens_hsa047132.75633314
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74342485
7GABAergic synapse_Homo sapiens_hsa047272.72076755
8Glutamatergic synapse_Homo sapiens_hsa047242.67970885
9Amphetamine addiction_Homo sapiens_hsa050312.59578922
10Morphine addiction_Homo sapiens_hsa050322.57755410
11Salivary secretion_Homo sapiens_hsa049702.27581948
12Dopaminergic synapse_Homo sapiens_hsa047282.19684305
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13791339
14Insulin secretion_Homo sapiens_hsa049112.11394140
15Gastric acid secretion_Homo sapiens_hsa049711.92074974
16Cholinergic synapse_Homo sapiens_hsa047251.87705730
17Taste transduction_Homo sapiens_hsa047421.82834163
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81653816
19Long-term depression_Homo sapiens_hsa047301.76894962
20Serotonergic synapse_Homo sapiens_hsa047261.69507270
21Renin secretion_Homo sapiens_hsa049241.69058835
22Collecting duct acid secretion_Homo sapiens_hsa049661.68157978
23Cocaine addiction_Homo sapiens_hsa050301.65240625
24Calcium signaling pathway_Homo sapiens_hsa040201.62766728
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61292008
26Oxytocin signaling pathway_Homo sapiens_hsa049211.60412241
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42094206
28GnRH signaling pathway_Homo sapiens_hsa049121.36879906
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34050895
30cAMP signaling pathway_Homo sapiens_hsa040241.30684464
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28875178
32Gap junction_Homo sapiens_hsa045401.27394890
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26503059
34Type II diabetes mellitus_Homo sapiens_hsa049301.15872509
35Nitrogen metabolism_Homo sapiens_hsa009101.15823573
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15237030
37Vibrio cholerae infection_Homo sapiens_hsa051101.12849282
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05851583
39Estrogen signaling pathway_Homo sapiens_hsa049151.04840931
40Pancreatic secretion_Homo sapiens_hsa049721.04462089
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03756579
42Glioma_Homo sapiens_hsa052141.03348289
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.01349318
44ErbB signaling pathway_Homo sapiens_hsa040121.00026028
45Axon guidance_Homo sapiens_hsa043600.98043884
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96565800
47Melanogenesis_Homo sapiens_hsa049160.94327794
48Vitamin B6 metabolism_Homo sapiens_hsa007500.94064333
49Cardiac muscle contraction_Homo sapiens_hsa042600.93390003
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88425136
51Thyroid hormone synthesis_Homo sapiens_hsa049180.82853867
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81456772
53Dorso-ventral axis formation_Homo sapiens_hsa043200.81219114
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.80836743
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80645860
56Phototransduction_Homo sapiens_hsa047440.80028454
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76688229
58Histidine metabolism_Homo sapiens_hsa003400.74862501
59Oocyte meiosis_Homo sapiens_hsa041140.74810580
60Ether lipid metabolism_Homo sapiens_hsa005650.68844369
61Choline metabolism in cancer_Homo sapiens_hsa052310.68775747
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68630160
63MAPK signaling pathway_Homo sapiens_hsa040100.67906692
64Dilated cardiomyopathy_Homo sapiens_hsa054140.63687314
65Ras signaling pathway_Homo sapiens_hsa040140.60540698
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59954672
67Inositol phosphate metabolism_Homo sapiens_hsa005620.59653071
68VEGF signaling pathway_Homo sapiens_hsa043700.56909429
69Butanoate metabolism_Homo sapiens_hsa006500.56729641
70Fatty acid biosynthesis_Homo sapiens_hsa000610.55698513
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.55627271
72Glucagon signaling pathway_Homo sapiens_hsa049220.53898667
73Rap1 signaling pathway_Homo sapiens_hsa040150.53612412
74Type I diabetes mellitus_Homo sapiens_hsa049400.51534974
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51514196
76Alzheimers disease_Homo sapiens_hsa050100.51100672
77beta-Alanine metabolism_Homo sapiens_hsa004100.49248460
78Endocytosis_Homo sapiens_hsa041440.48108185
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.47773402
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44549281
81Bile secretion_Homo sapiens_hsa049760.44273227
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43930402
83African trypanosomiasis_Homo sapiens_hsa051430.43542755
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43024983
85Alcoholism_Homo sapiens_hsa050340.42717886
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41845046
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41793304
88Circadian rhythm_Homo sapiens_hsa047100.41105550
89ABC transporters_Homo sapiens_hsa020100.40961642
90Regulation of autophagy_Homo sapiens_hsa041400.39830881
91mTOR signaling pathway_Homo sapiens_hsa041500.38536698
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38345124
93Prion diseases_Homo sapiens_hsa050200.37060643
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36711566
95Renal cell carcinoma_Homo sapiens_hsa052110.36272539
96Non-small cell lung cancer_Homo sapiens_hsa052230.35776828
97Ovarian steroidogenesis_Homo sapiens_hsa049130.35328593
98Wnt signaling pathway_Homo sapiens_hsa043100.33540355
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.32387491
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31275344
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31070619
102Glycerolipid metabolism_Homo sapiens_hsa005610.31029264
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.30573163
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30011878
105Linoleic acid metabolism_Homo sapiens_hsa005910.29923713
106Oxidative phosphorylation_Homo sapiens_hsa001900.29694173
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29598774
108Chemokine signaling pathway_Homo sapiens_hsa040620.29205955
109Parkinsons disease_Homo sapiens_hsa050120.28791345
110Rheumatoid arthritis_Homo sapiens_hsa053230.27076314
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26391924
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26229842
113Mineral absorption_Homo sapiens_hsa049780.24090297
114Insulin signaling pathway_Homo sapiens_hsa049100.23980278
115Arginine and proline metabolism_Homo sapiens_hsa003300.20220202
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17460668
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16707986

Most similar genes based on co-expression Upload to Enrichr

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