SLC24A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.88190458
2vocalization behavior (GO:0071625)5.62067822
3sarcoplasmic reticulum calcium ion transport (GO:0070296)5.40692871
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.34481318
5locomotory exploration behavior (GO:0035641)5.32761521
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.19750296
7synaptic vesicle exocytosis (GO:0016079)5.17249103
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15471791
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.05671587
10synaptic vesicle maturation (GO:0016188)5.04760101
11actin-myosin filament sliding (GO:0033275)5.02538166
12muscle filament sliding (GO:0030049)5.02538166
13neuron cell-cell adhesion (GO:0007158)4.92646535
14skeletal muscle contraction (GO:0003009)4.82356684
15regulation of glutamate receptor signaling pathway (GO:1900449)4.80276155
16glutamate secretion (GO:0014047)4.75514548
17protein localization to synapse (GO:0035418)4.70343005
18glutamate receptor signaling pathway (GO:0007215)4.67651695
19regulation of synaptic vesicle exocytosis (GO:2000300)4.57617867
20regulation of skeletal muscle contraction (GO:0014819)4.52645184
21exploration behavior (GO:0035640)4.50608303
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.43944457
23neuronal action potential propagation (GO:0019227)4.40436073
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.31177053
25neurotransmitter secretion (GO:0007269)4.29127372
26synaptic transmission, glutamatergic (GO:0035249)4.25562249
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.25175163
28gamma-aminobutyric acid signaling pathway (GO:0007214)4.20515188
29actin-mediated cell contraction (GO:0070252)4.20262112
30regulation of neuronal synaptic plasticity (GO:0048168)4.15931103
31regulation of synaptic vesicle transport (GO:1902803)4.14435489
32cellular potassium ion homeostasis (GO:0030007)4.13479832
33neuron-neuron synaptic transmission (GO:0007270)4.08316090
34neuron recognition (GO:0008038)3.98522655
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.97786319
36layer formation in cerebral cortex (GO:0021819)3.95821830
37gamma-aminobutyric acid transport (GO:0015812)3.92132209
38dendritic spine morphogenesis (GO:0060997)3.90884232
39long-term memory (GO:0007616)3.90326461
40positive regulation of synapse maturation (GO:0090129)3.82496523
41sodium ion export (GO:0071436)3.79634965
42regulation of synapse structural plasticity (GO:0051823)3.78573411
43proline transport (GO:0015824)3.77643263
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.76695755
45regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.74733341
46neurotransmitter-gated ion channel clustering (GO:0072578)3.68227076
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.65878233
48neurotransmitter transport (GO:0006836)3.63401864
49regulation of postsynaptic membrane potential (GO:0060078)3.62697086
50synaptic vesicle endocytosis (GO:0048488)3.61674223
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.61432554
52positive regulation of membrane potential (GO:0045838)3.58601682
53transmission of nerve impulse (GO:0019226)3.57598141
54axonal fasciculation (GO:0007413)3.57381966
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.54351032
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53914919
57skeletal muscle fiber development (GO:0048741)3.51460278
58striated muscle contraction (GO:0006941)3.51235776
59regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.49288907
60regulation of synaptic plasticity (GO:0048167)3.47031646
61long-term synaptic potentiation (GO:0060291)3.45612820
62regulation of dendritic spine morphogenesis (GO:0061001)3.43322222
63regulation of female receptivity (GO:0045924)3.43012029
64regulation of vesicle fusion (GO:0031338)3.42566311
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38950444
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.35538682
67myofibril assembly (GO:0030239)3.35284319
68myotube cell development (GO:0014904)3.34440512
69regulation of neurotransmitter levels (GO:0001505)3.33225992
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.33214979
71negative regulation of norepinephrine secretion (GO:0010700)3.32762368
72postsynaptic membrane organization (GO:0001941)3.32299895
73innervation (GO:0060384)3.31377428
74response to histamine (GO:0034776)3.31044102
75activation of protein kinase A activity (GO:0034199)3.29534820
76presynaptic membrane assembly (GO:0097105)3.23882482
77negative regulation of muscle contraction (GO:0045932)3.22619900
78actin filament-based movement (GO:0030048)3.18708946
79negative regulation of protein localization to cell surface (GO:2000009)3.18496597
80behavioral fear response (GO:0001662)3.18017834
81behavioral defense response (GO:0002209)3.18017834
82regulation of relaxation of muscle (GO:1901077)3.17147831
83cerebellar Purkinje cell differentiation (GO:0021702)3.16773883
84cell communication by electrical coupling (GO:0010644)3.14208622
85regulation of neurotransmitter secretion (GO:0046928)3.13515103
86mating behavior (GO:0007617)3.12627223
87membrane depolarization (GO:0051899)3.12594000
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11054271
89learning (GO:0007612)3.10958296
90glycogen catabolic process (GO:0005980)3.08427476
91response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.07844518
92synapse assembly (GO:0007416)3.07189293
93muscle contraction (GO:0006936)3.06864519
94creatine metabolic process (GO:0006600)3.06480259
95membrane hyperpolarization (GO:0060081)3.05749711
96positive regulation of dendritic spine development (GO:0060999)3.04551910
97dendritic spine organization (GO:0097061)3.03977689
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03778655
99neuromuscular process controlling balance (GO:0050885)3.03233876
100presynaptic membrane organization (GO:0097090)3.03044877
101startle response (GO:0001964)3.02766266
102regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.02529793
103positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02082973
104regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.01770692
105membrane depolarization during action potential (GO:0086010)3.01495578
106relaxation of muscle (GO:0090075)3.01308934
107regulation of dendritic spine development (GO:0060998)2.99121263
108positive regulation of dendritic spine morphogenesis (GO:0061003)2.98992786
109fear response (GO:0042596)2.98730898
110long term synaptic depression (GO:0060292)2.98114305
111cellular sodium ion homeostasis (GO:0006883)2.97564764
112skeletal muscle tissue regeneration (GO:0043403)2.97541030
113regulation of synapse maturation (GO:0090128)2.97155806
114social behavior (GO:0035176)2.96657395
115intraspecies interaction between organisms (GO:0051703)2.96657395
116neuromuscular process controlling posture (GO:0050884)2.96423926
117G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.95723493
118regulation of calcium ion transmembrane transport (GO:1903169)2.95354605
119regulation of calcium ion transmembrane transporter activity (GO:1901019)2.95354605
120negative regulation of homotypic cell-cell adhesion (GO:0034111)2.94469560
121synaptic transmission (GO:0007268)2.93618424
122regulation of cell communication by electrical coupling (GO:0010649)2.93441908
123regulation of synaptic transmission (GO:0050804)2.92586498
124dendrite morphogenesis (GO:0048813)2.91540813
125glucan catabolic process (GO:0009251)2.91466797
126glycine transport (GO:0015816)2.90758386
127vesicle transport along microtubule (GO:0047496)2.90211817
128regulation of neurotransmitter transport (GO:0051588)2.89658719
129positive regulation of synaptic transmission (GO:0050806)2.88196823
130synapse organization (GO:0050808)2.87158968
131cerebellar granule cell differentiation (GO:0021707)2.87107843
132negative regulation of calcium ion transmembrane transport (GO:1903170)2.86989664
133negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.86989664
134positive regulation of neurotransmitter secretion (GO:0001956)2.86460600
135regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.83370277
136regulation of platelet aggregation (GO:0090330)2.82511803
137skeletal muscle adaptation (GO:0043501)2.82209850
138muscle system process (GO:0003012)2.81245959
139female mating behavior (GO:0060180)2.78358424
140cGMP-mediated signaling (GO:0019934)2.74142807
141cellular polysaccharide catabolic process (GO:0044247)2.71633556
142negative regulation of heart contraction (GO:0045822)2.70264769
143regulation of cAMP-dependent protein kinase activity (GO:2000479)2.67550206
144positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.67124338
145cardiac muscle contraction (GO:0060048)2.62410321
146sarcomere organization (GO:0045214)2.60930558
147cellular response to epinephrine stimulus (GO:0071872)2.59902684
148potassium ion import (GO:0010107)2.55883694
149muscle fiber development (GO:0048747)2.55316698
150negative regulation of platelet activation (GO:0010544)2.54034341
151cellular response to monoamine stimulus (GO:0071868)2.53410194
152cellular response to catecholamine stimulus (GO:0071870)2.53410194
153regulation of lipoprotein metabolic process (GO:0050746)2.53245246
154response to muscle activity (GO:0014850)2.52194371
155cardiac myofibril assembly (GO:0055003)2.51736128
156negative regulation of blood circulation (GO:1903523)2.51463634
157positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.50470191
158regulation of integrin-mediated signaling pathway (GO:2001044)2.50164664
159neurotransmitter uptake (GO:0001504)2.49904835
160striated muscle adaptation (GO:0014888)2.44748380
161polysaccharide catabolic process (GO:0000272)2.44660806
162adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.44372388
163myelination in peripheral nervous system (GO:0022011)2.41271002
164peripheral nervous system axon ensheathment (GO:0032292)2.41271002
165neuromuscular synaptic transmission (GO:0007274)2.40491578
166negative regulation of catecholamine secretion (GO:0033604)2.40490364
167plasma membrane repair (GO:0001778)2.40356906
168response to inactivity (GO:0014854)2.39775025
169cardiac muscle hypertrophy (GO:0003300)2.39344324
170adenosine receptor signaling pathway (GO:0001973)2.38040778
171regulation of clathrin-mediated endocytosis (GO:2000369)2.37546759
172regulation of protein localization to cell surface (GO:2000008)2.36947502
173myotube differentiation (GO:0014902)2.36585539
174regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.36430645
175regulation of platelet activation (GO:0010543)2.35187006
176positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.34233220
177regulation of actin filament-based movement (GO:1903115)2.31321493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98636653
2GBX2_23144817_ChIP-Seq_PC3_Human3.72151611
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16323130
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15320302
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14712822
6* ESR1_20079471_ChIP-ChIP_T-47D_Human2.96294946
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77487769
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77487769
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69527308
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67633864
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62973696
12REST_21632747_ChIP-Seq_MESCs_Mouse2.57869618
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55012388
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50386662
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49573863
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.48164044
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.45359933
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.38527503
19DROSHA_22980978_ChIP-Seq_HELA_Human2.33056798
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25634894
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.24694843
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.23745471
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.22740314
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.18786194
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.07583148
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06758896
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.94603713
28* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.94313683
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94002864
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92027674
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91719948
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89302290
33AR_21572438_ChIP-Seq_LNCaP_Human1.88775722
34TAF15_26573619_Chip-Seq_HEK293_Human1.83106874
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75734138
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70882484
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.69299768
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64347352
39* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58516748
40* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50283185
41ZNF274_21170338_ChIP-Seq_K562_Hela1.50171906
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49919187
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49131968
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.45622176
45* P300_19829295_ChIP-Seq_ESCs_Human1.44233668
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43821077
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38479031
48* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37800963
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34743611
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33979866
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.32773365
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.32344655
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32180092
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.32004761
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30752798
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30717085
57* CBX2_27304074_Chip-Seq_ESCs_Mouse1.30391958
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30344491
59* AR_25329375_ChIP-Seq_VCAP_Human1.29986797
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.29187240
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28630218
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28191564
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27708445
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24260455
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24238020
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23679994
67IGF1R_20145208_ChIP-Seq_DFB_Human1.21515994
68* STAT3_23295773_ChIP-Seq_U87_Human1.19477306
69AR_19668381_ChIP-Seq_PC3_Human1.18289727
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.17436969
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17322844
72FUS_26573619_Chip-Seq_HEK293_Human1.15521557
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15330772
74PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14792249
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13645785
76TP53_16413492_ChIP-PET_HCT116_Human1.11514270
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10731212
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10263786
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09620848
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08586133
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08482971
82VDR_22108803_ChIP-Seq_LS180_Human1.07888913
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07174843
84* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06969644
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.06766686
86* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06530059
87* TCF4_23295773_ChIP-Seq_U87_Human1.05938893
88* ARNT_22903824_ChIP-Seq_MCF-7_Human1.05704068
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04085015
90RNF2_27304074_Chip-Seq_NSC_Mouse1.03197751
91AHR_22903824_ChIP-Seq_MCF-7_Human1.03091596
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02426531
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.01509226
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01370078
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00978900
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00567388
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00430285
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.00421036
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.00421036
100BCAT_22108803_ChIP-Seq_LS180_Human0.99885662
101CTCF_27219007_Chip-Seq_Bcells_Human0.99419114
102TP53_20018659_ChIP-ChIP_R1E_Mouse0.98872045
103* RUNX2_22187159_ChIP-Seq_PCA_Human0.98366396
104P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98103957
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96864984
106TP53_18474530_ChIP-ChIP_U2OS_Human0.96510066
107EP300_21415370_ChIP-Seq_HL-1_Mouse0.96274011
108KDM2B_26808549_Chip-Seq_K562_Human0.95463170
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94999215
110ER_23166858_ChIP-Seq_MCF-7_Human0.93925073
111JUN_21703547_ChIP-Seq_K562_Human0.93654943
112GATA1_19941826_ChIP-Seq_K562_Human0.93335548
113* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92803205
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.92715325
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.92241604
116SCL_19346495_ChIP-Seq_HPC-7_Human0.91130627
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90233428
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89977284
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.89941767
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89682439
121TRIM28_21343339_ChIP-Seq_HEK293_Human0.89576799
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89021127
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89021127
124* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88618471
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87782900
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87669297
127GATA2_19941826_ChIP-Seq_K562_Human0.86929463
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86526855
129* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86502504
130ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86405837
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85045995
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85045995
133* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84648909
134GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84072012
135VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82665430
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81556164
137SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81228964
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80688752
139* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78893441
140GF1_26923725_Chip-Seq_HPCs_Mouse0.77379090
141MYC_27129775_Chip-Seq_CORNEA_Mouse0.74482767
142* RUNX1_27514584_Chip-Seq_MCF-7_Human0.72359400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.25603874
2MP0003880_abnormal_central_pattern5.45126886
3MP0003635_abnormal_synaptic_transmissio4.16388532
4MP0009745_abnormal_behavioral_response3.45088617
5MP0004270_analgesia3.38535171
6MP0004036_abnormal_muscle_relaxation3.35787077
7MP0002063_abnormal_learning/memory/cond3.28461960
8MP0002064_seizures3.21164835
9MP0000749_muscle_degeneration3.19307591
10MP0009046_muscle_twitch3.09073051
11MP0001968_abnormal_touch/_nociception2.89964157
12MP0005423_abnormal_somatic_nervous2.80340264
13MP0002572_abnormal_emotion/affect_behav2.76537017
14MP0003646_muscle_fatigue2.71844950
15MP0002272_abnormal_nervous_system2.70669600
16MP0001501_abnormal_sleep_pattern2.62277748
17MP0004084_abnormal_cardiac_muscle2.55217415
18MP0001486_abnormal_startle_reflex2.54715221
19MP0002734_abnormal_mechanical_nocicepti2.48586749
20MP0005464_abnormal_platelet_physiology2.41156894
21MP0002736_abnormal_nociception_after2.24877020
22MP0001440_abnormal_grooming_behavior2.24720834
23MP0008004_abnormal_stomach_pH2.17951409
24MP0005620_abnormal_muscle_contractility2.16388772
25MP0002735_abnormal_chemical_nociception2.12718372
26MP0003329_amyloid_beta_deposits2.08532081
27MP0000759_abnormal_skeletal_muscle2.04249064
28MP0002067_abnormal_sensory_capabilities2.00725301
29MP0002822_catalepsy1.99755743
30MP0000747_muscle_weakness1.97658830
31MP0004087_abnormal_muscle_fiber1.96190900
32MP0002106_abnormal_muscle_physiology1.95230610
33MP0002733_abnormal_thermal_nociception1.93005049
34MP0001970_abnormal_pain_threshold1.88591962
35MP0002332_abnormal_exercise_endurance1.88587414
36MP0006276_abnormal_autonomic_nervous1.87888158
37MP0005666_abnormal_adipose_tissue1.85330483
38MP0009780_abnormal_chondrocyte_physiolo1.83205945
39MP0005369_muscle_phenotype1.82249902
40MP0002184_abnormal_innervation1.81731944
41MP0000778_abnormal_nervous_system1.75148774
42MP0008569_lethality_at_weaning1.72988352
43MP0005386_behavior/neurological_phenoty1.70811159
44MP0004924_abnormal_behavior1.70811159
45MP0002557_abnormal_social/conspecific_i1.68066722
46MP0002108_abnormal_muscle_morphology1.65094791
47MP0002909_abnormal_adrenal_gland1.63838999
48MP0001984_abnormal_olfaction1.60988538
49MP0004185_abnormal_adipocyte_glucose1.55909422
50MP0004858_abnormal_nervous_system1.52420017
51MP0005551_abnormal_eye_electrophysiolog1.52388519
52MP0005670_abnormal_white_adipose1.52008924
53MP0004811_abnormal_neuron_physiology1.51770785
54MP0001529_abnormal_vocalization1.51416628
55MP0006138_congestive_heart_failure1.49132493
56MP0004885_abnormal_endolymph1.48945155
57MP0002972_abnormal_cardiac_muscle1.45375645
58MP0002837_dystrophic_cardiac_calcinosis1.45079372
59MP0000955_abnormal_spinal_cord1.43810032
60MP0002882_abnormal_neuron_morphology1.40865291
61MP0003879_abnormal_hair_cell1.40458821
62MP0002066_abnormal_motor_capabilities/c1.39989220
63MP0003787_abnormal_imprinting1.37360987
64MP0000750_abnormal_muscle_regeneration1.36352040
65MP0004142_abnormal_muscle_tone1.34037239
66MP0001905_abnormal_dopamine_level1.33741682
67MP0005646_abnormal_pituitary_gland1.32352030
68MP0003633_abnormal_nervous_system1.31285785
69MP0005375_adipose_tissue_phenotype1.30638543
70MP0001502_abnormal_circadian_rhythm1.29338611
71MP0005645_abnormal_hypothalamus_physiol1.25229919
72MP0002269_muscular_atrophy1.23339312
73MP0001188_hyperpigmentation1.19158683
74MP0004145_abnormal_muscle_electrophysio1.18831424
75MP0003122_maternal_imprinting1.17050957
76MP0002971_abnormal_brown_adipose1.16696587
77MP0000751_myopathy1.15711439
78MP0000230_abnormal_systemic_arterial1.13648872
79MP0002653_abnormal_ependyma_morphology1.12855110
80MP0001544_abnormal_cardiovascular_syste1.12708501
81MP0005385_cardiovascular_system_phenoty1.12708501
82MP0000579_abnormal_nail_morphology1.11818319
83MP0003631_nervous_system_phenotype1.11736360
84MP0004742_abnormal_vestibular_system1.10807300
85MP0002229_neurodegeneration1.09242356
86MP0005083_abnormal_biliary_tract1.08801095
87MP0003705_abnormal_hypodermis_morpholog1.08075289
88MP0003638_abnormal_response/metabolism_1.06641265
89MP0000013_abnormal_adipose_tissue1.06149600
90MP0010386_abnormal_urinary_bladder1.04770389
91MP0002152_abnormal_brain_morphology1.04738611
92MP0005535_abnormal_body_temperature0.99910276
93MP0008775_abnormal_heart_ventricle0.99681650
94MP0005275_abnormal_skin_tensile0.99317202
95MP0002090_abnormal_vision0.98675526
96MP0000604_amyloidosis0.95749492
97MP0001879_abnormal_lymphatic_vessel0.94626907
98MP0004215_abnormal_myocardial_fiber0.94288365
99MP0008872_abnormal_physiological_respon0.93903119
100MP0000733_abnormal_muscle_development0.93703893
101MP0002069_abnormal_eating/drinking_beha0.93142343
102MP0005330_cardiomyopathy0.93080514
103MP0003690_abnormal_glial_cell0.92348900
104MP0003634_abnormal_glial_cell0.90011967
105MP0002796_impaired_skin_barrier0.89868112
106MP0001963_abnormal_hearing_physiology0.89823130
107MP0006072_abnormal_retinal_apoptosis0.89613383
108MP0001177_atelectasis0.88294477
109MP0008874_decreased_physiological_sensi0.87719275
110MP0003724_increased_susceptibility_to0.86541356
111MP0000920_abnormal_myelination0.85757019
112MP0004484_altered_response_of0.84444380
113MP0002752_abnormal_somatic_nervous0.84250374
114MP0004085_abnormal_heartbeat0.81585371
115MP0003632_abnormal_nervous_system0.80483503
116MP0003828_pulmonary_edema0.80177080
117MP0002127_abnormal_cardiovascular_syste0.79691359
118MP0006036_abnormal_mitochondrial_physio0.77546853
119MP0005451_abnormal_body_composition0.75836658
120MP0010630_abnormal_cardiac_muscle0.75412830
121MP0003075_altered_response_to0.74216533
122MP0005623_abnormal_meninges_morphology0.73002989
123MP0003566_abnormal_cell_adhesion0.70489655
124MP0002638_abnormal_pupillary_reflex0.70401671
125MP0004233_abnormal_muscle_weight0.69054103
126MP0002876_abnormal_thyroid_physiology0.68772996
127MP0005409_darkened_coat_color0.68579390
128MP0000343_altered_response_to0.67804069
129MP0000631_abnormal_neuroendocrine_gland0.67704965
130MP0005394_taste/olfaction_phenotype0.67228842
131MP0005499_abnormal_olfactory_system0.67228842
132MP0003011_delayed_dark_adaptation0.67178504
133MP0001664_abnormal_digestion0.67018563
134MP0003045_fibrosis0.64248655
135MP0005253_abnormal_eye_physiology0.64013037
136MP0005187_abnormal_penis_morphology0.63995616
137MP0010329_abnormal_lipoprotein_level0.62241452
138MP0001485_abnormal_pinna_reflex0.61363838
139MP0000465_gastrointestinal_hemorrhage0.61161645
140MP0003137_abnormal_impulse_conducting0.59879101
141MP0008961_abnormal_basal_metabolism0.58763283
142MP0004130_abnormal_muscle_cell0.56393338
143MP0000026_abnormal_inner_ear0.55748629
144MP0003283_abnormal_digestive_organ0.54932040
145MP0001943_abnormal_respiration0.54075647
146MP0010234_abnormal_vibrissa_follicle0.52787776
147MP0005167_abnormal_blood-brain_barrier0.52334565
148MP0001299_abnormal_eye_distance/0.52205857
149MP0004510_myositis0.50905900
150MP0005595_abnormal_vascular_smooth0.50363024

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.12449317
2Muscle fiber inclusion bodies (HP:0100299)7.74000417
3Nemaline bodies (HP:0003798)7.60012517
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.36312011
5Exercise-induced myalgia (HP:0003738)6.17499272
6Myokymia (HP:0002411)5.98279461
7Type 1 muscle fiber predominance (HP:0003803)5.92139845
8Focal seizures (HP:0007359)5.81274830
9Visual hallucinations (HP:0002367)5.64394737
10Epileptic encephalopathy (HP:0200134)4.95403957
11Atonic seizures (HP:0010819)4.80501053
12Exercise-induced muscle cramps (HP:0003710)4.78067881
13Hyporeflexia of lower limbs (HP:0002600)4.75508828
14Distal arthrogryposis (HP:0005684)4.75073804
15Progressive cerebellar ataxia (HP:0002073)4.58807905
16Febrile seizures (HP:0002373)4.53956394
17Muscle fiber splitting (HP:0003555)4.52576456
18Absence seizures (HP:0002121)4.51474949
19Muscle hypertrophy of the lower extremities (HP:0008968)4.34045091
20Abnormality of skeletal muscle fiber size (HP:0012084)4.12859270
21Dialeptic seizures (HP:0011146)4.11313167
22Prolonged bleeding time (HP:0003010)4.07334139
23Generalized tonic-clonic seizures (HP:0002069)4.05250216
24Round ear (HP:0100830)4.01725939
25Menorrhagia (HP:0000132)3.87995763
26EMG: myopathic abnormalities (HP:0003458)3.86674495
27Supranuclear gaze palsy (HP:0000605)3.84544194
28Myopathic facies (HP:0002058)3.84501043
29Calf muscle hypertrophy (HP:0008981)3.83546959
30Increased variability in muscle fiber diameter (HP:0003557)3.74350382
31Action tremor (HP:0002345)3.72168372
32Increased mean platelet volume (HP:0011877)3.70418899
33Difficulty running (HP:0009046)3.70307458
34Hyperventilation (HP:0002883)3.65529206
35Cerebral inclusion bodies (HP:0100314)3.61389712
36Neurofibrillary tangles (HP:0002185)3.56751364
37Broad-based gait (HP:0002136)3.55242164
38Distal lower limb muscle weakness (HP:0009053)3.52753364
39Centrally nucleated skeletal muscle fibers (HP:0003687)3.46194379
40Dysdiadochokinesis (HP:0002075)3.42298084
41Abnormality of the calf musculature (HP:0001430)3.39794039
42Ulnar deviation of the wrist (HP:0003049)3.35308106
43Abnormal platelet volume (HP:0011876)3.34216038
44Neck muscle weakness (HP:0000467)3.25521668
45Dysmetria (HP:0001310)3.25099547
46Rimmed vacuoles (HP:0003805)3.17258622
47Frequent falls (HP:0002359)3.14858161
48Abnormality of the left ventricular outflow tract (HP:0011103)3.13870160
49Subaortic stenosis (HP:0001682)3.13870160
50Gaze-evoked nystagmus (HP:0000640)3.13294137
51Mutism (HP:0002300)3.11767622
52Truncal ataxia (HP:0002078)3.10059501
53Depression (HP:0000716)3.08311999
54Amblyopia (HP:0000646)3.02687472
55Calcaneovalgus deformity (HP:0001848)3.02352562
56Anxiety (HP:0000739)3.01111638
57Sudden death (HP:0001699)2.99454031
58Hemiparesis (HP:0001269)2.97529202
59Diplopia (HP:0000651)2.97312539
60Abnormality of binocular vision (HP:0011514)2.97312539
61Poor eye contact (HP:0000817)2.96632598
62Petechiae (HP:0000967)2.95844713
63Impaired vibration sensation in the lower limbs (HP:0002166)2.94737973
64Excessive salivation (HP:0003781)2.94525277
65Drooling (HP:0002307)2.94525277
66Abnormal eating behavior (HP:0100738)2.93683317
67Progressive inability to walk (HP:0002505)2.93422817
68Bundle branch block (HP:0011710)2.88168673
69Increased connective tissue (HP:0009025)2.86233320
70Purpura (HP:0000979)2.86030895
71Myoglobinuria (HP:0002913)2.85926241
72Absent phalangeal crease (HP:0006109)2.85440419
73Abnormal social behavior (HP:0012433)2.80237415
74Impaired social interactions (HP:0000735)2.80237415
75Distal lower limb amyotrophy (HP:0008944)2.78732696
76Genetic anticipation (HP:0003743)2.77506413
77EMG: neuropathic changes (HP:0003445)2.76331484
78Urinary bladder sphincter dysfunction (HP:0002839)2.75156763
79Postural instability (HP:0002172)2.74103638
80Ankle clonus (HP:0011448)2.73990689
81Papilledema (HP:0001085)2.63911762
82Rhabdomyolysis (HP:0003201)2.63031780
83Areflexia of lower limbs (HP:0002522)2.59491887
84Myotonia (HP:0002486)2.55178955
85Deformed tarsal bones (HP:0008119)2.54294165
86Hemiplegia (HP:0002301)2.53108148
87Scanning speech (HP:0002168)2.52974850
88Absent speech (HP:0001344)2.50085753
89Intention tremor (HP:0002080)2.47789475
90Epileptiform EEG discharges (HP:0011182)2.47670211
91Lower limb amyotrophy (HP:0007210)2.47490502
92Obstructive sleep apnea (HP:0002870)2.47157232
93Asymmetric septal hypertrophy (HP:0001670)2.46912258
94Bradykinesia (HP:0002067)2.42072134
95Scapular winging (HP:0003691)2.41330822
96Bulbar palsy (HP:0001283)2.39300270
97Impaired smooth pursuit (HP:0007772)2.37827732
98Muscle stiffness (HP:0003552)2.35291366
99Polyphagia (HP:0002591)2.35264389
100Abnormal finger flexion creases (HP:0006143)2.33676606
101Malignant hyperthermia (HP:0002047)2.32479173
102EEG with generalized epileptiform discharges (HP:0011198)2.32457686
103Termporal pattern (HP:0011008)2.31770206
104Insidious onset (HP:0003587)2.31770206
105Spinal rigidity (HP:0003306)2.31014003
106Akinesia (HP:0002304)2.30561416
107Abnormality of the corticospinal tract (HP:0002492)2.29263947
108Gowers sign (HP:0003391)2.27444219
109Spastic gait (HP:0002064)2.27252867
110Generalized myoclonic seizures (HP:0002123)2.26171942
111Foot dorsiflexor weakness (HP:0009027)2.24165627
112Urinary urgency (HP:0000012)2.23355719
113Status epilepticus (HP:0002133)2.20948445
114Abnormality of the lower motor neuron (HP:0002366)2.20244592
115Epistaxis (HP:0000421)2.20230822
116Mildly elevated creatine phosphokinase (HP:0008180)2.16737305
117Abnormality of the foot musculature (HP:0001436)2.16120409
118Limb dystonia (HP:0002451)2.15799219
119Torticollis (HP:0000473)2.15263267
120Fetal akinesia sequence (HP:0001989)2.15130251
121Stereotypic behavior (HP:0000733)2.14282420
122Abnormality of ocular smooth pursuit (HP:0000617)2.12675114
123Hypsarrhythmia (HP:0002521)2.12338116
124Inability to walk (HP:0002540)2.12098854
125Focal dystonia (HP:0004373)2.11907929
126Delusions (HP:0000746)2.11718852
127Lower limb muscle weakness (HP:0007340)2.08480907
128Pheochromocytoma (HP:0002666)2.08198568
129Megalencephaly (HP:0001355)2.07998639
130Ventricular fibrillation (HP:0001663)2.06807504
131Psychosis (HP:0000709)2.06124315
132Neuronal loss in central nervous system (HP:0002529)2.05788762
133Rapidly progressive (HP:0003678)2.05120664
134Weak cry (HP:0001612)2.01923699
135Hyperlipoproteinemia (HP:0010980)2.01530258
136Abnormality of salivation (HP:0100755)2.00221019
137Oligomenorrhea (HP:0000876)1.99561871
138Heart block (HP:0012722)1.98355226
139Generalized muscle weakness (HP:0003324)1.98350039
140Slender build (HP:0001533)1.97855058
141Gait ataxia (HP:0002066)1.97188828
142Dysmetric saccades (HP:0000641)1.96064517
143Gingival bleeding (HP:0000225)1.95805500
144Retinal dysplasia (HP:0007973)1.95643091
145Amyotrophic lateral sclerosis (HP:0007354)1.92544427
146Impaired vibratory sensation (HP:0002495)1.91716936
147Central scotoma (HP:0000603)1.91588272
148Agitation (HP:0000713)1.91345321
149Ventricular arrhythmia (HP:0004308)1.90824617
150Abnormal atrioventricular conduction (HP:0005150)1.90215262
151Neuroendocrine neoplasm (HP:0100634)1.88925044
152Hyperkalemia (HP:0002153)1.87818067
153Back pain (HP:0003418)1.86990711
154Hypoventilation (HP:0002791)1.86421150
155Craniofacial dystonia (HP:0012179)1.83092113
156Blue irides (HP:0000635)1.82267430
157Hyperthyroidism (HP:0000836)1.81377399
158Ventricular tachycardia (HP:0004756)1.80650446
159Incomplete penetrance (HP:0003829)1.79646052
160Inappropriate behavior (HP:0000719)1.77770328
161Rigidity (HP:0002063)1.76486605
162Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76370762
163Degeneration of the lateral corticospinal tracts (HP:0002314)1.76370762
164Difficulty climbing stairs (HP:0003551)1.76121695
165Thickened helices (HP:0000391)1.76028907
166Dilated cardiomyopathy (HP:0001644)1.75799987
167Aortic aneurysm (HP:0004942)1.75758947
168Waddling gait (HP:0002515)1.75548321
169Abnormality of macular pigmentation (HP:0008002)1.74191927
170Type II lissencephaly (HP:0007260)1.73971232
171Paralysis (HP:0003470)1.73929692
172Steppage gait (HP:0003376)1.73452909
173Aplasia involving bones of the upper limbs (HP:0009823)1.73288756
174Aplasia of the phalanges of the hand (HP:0009802)1.73288756
175Aplasia involving bones of the extremities (HP:0009825)1.73288756
176Abnormality of the neuromuscular junction (HP:0003398)1.71932201
177Fatigable weakness (HP:0003473)1.71932201
178Syncope (HP:0001279)1.71799250
179Protruding tongue (HP:0010808)1.71596796
180Hypercortisolism (HP:0001578)1.71103910
181Clumsiness (HP:0002312)1.70618096
182Hip contracture (HP:0003273)1.69785424
183Nonprogressive disorder (HP:0003680)1.67010782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.75018280
2NTRK34.50362803
3EPHA44.24692030
4MAP3K93.67197407
5TTN3.29619111
6MAP3K43.05958890
7MINK12.70861966
8RIPK42.65432126
9MARK12.54792098
10TRIB32.52116099
11MAP2K72.46010901
12MAP3K122.32998809
13PNCK2.17642451
14MAPKAPK32.17249933
15NTRK22.13040194
16PAK62.05336522
17KSR22.02313428
18NTRK12.02004940
19MAP2K42.01678394
20CASK1.97201266
21DAPK21.91953532
22MYLK1.75036977
23PLK21.67898120
24PIK3CG1.66133481
25GRK51.65789278
26PRKD31.61118148
27KSR11.59322453
28SIK21.55377542
29CDK51.53045421
30TNIK1.51003774
31FES1.50128371
32ARAF1.49910960
33MAP3K131.41545242
34CAMKK11.40753643
35RIPK11.33455916
36DAPK11.32092324
37STK381.29883269
38BMX1.29218184
39PRKCG1.26235833
40SIK11.24756893
41MAPK131.18008508
42CAMK2A1.16389566
43PIK3CA1.14689233
44TYRO31.08529100
45PRPF4B1.07966688
46BMPR21.07609092
47PTK2B1.05674452
48LATS21.04128016
49NME11.03821849
50TESK11.03405215
51CAMK2B1.02363057
52CDK191.00146277
53CAMK1G0.98690867
54MAP3K20.96146973
55UHMK10.94227654
56RAF10.90035221
57PHKG10.89954811
58PHKG20.89954811
59CDK140.88546446
60CDK180.87570034
61CDK150.86880723
62PAK30.86708300
63CAMK10.86093912
64DYRK1A0.80367565
65STK110.80087144
66FGR0.77065324
67CAMKK20.76736698
68CDK11A0.75282137
69TNK20.75148442
70OXSR10.72077624
71ILK0.71475636
72PRKCH0.71226849
73RET0.71130243
74CAMK2D0.70783094
75FER0.70750077
76MAPK40.68597485
77MAP3K60.67510081
78SGK4940.66696795
79SGK2230.66696795
80MAP2K30.66347253
81ROCK10.66219419
82SGK10.66066831
83LMTK20.65949410
84PRKG10.64305669
85MAP2K20.61867320
86PDK10.60335847
87EEF2K0.60144978
88PINK10.59623262
89PRKCE0.59221569
90ROCK20.59083420
91CSNK1G20.58768307
92PRKD10.58550628
93DDR20.58255958
94PDPK10.58241498
95MARK20.58210066
96EPHB10.57237136
97PDGFRA0.56199903
98MAP3K10.55013261
99MAP3K70.54548523
100GRK70.54355138
101MAPK70.54285620
102CAMK2G0.53026490
103PRKCZ0.53015702
104DMPK0.51972769
105PKN20.49390104
106FYN0.48496882
107CAMK40.47695606
108MAPK100.47655012
109RPS6KA30.45851052
110MOS0.45470776
111PDGFRB0.45468067
112WNK10.44583178
113DYRK1B0.44247494
114RPS6KA20.44111438
115PRKAA10.42668789
116MAP2K10.42354840
117SGK20.42326185
118DAPK30.42074394
119STK38L0.41533485
120TRPM70.41032550
121RPS6KB10.40775187
122ZAP700.40362234
123MAPKAPK50.39621046
124STK390.39580938
125ALK0.39172108
126EPHA30.38612056
127PRKAA20.37338116
128PKN10.37337166
129TAOK10.36914362
130LIMK10.36682536
131NEK60.35965352
132ABL20.35816367
133CDC42BPA0.35438394
134MAPK120.34792303
135MUSK0.34319875
136PRKACG0.34215153
137SGK30.34187721
138PRKACA0.32467736
139DYRK20.32241057
140SYK0.32217088
141PAK20.31816752

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.13240754
2Synaptic vesicle cycle_Homo sapiens_hsa047213.10061370
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84633747
4GABAergic synapse_Homo sapiens_hsa047272.81549393
5Long-term potentiation_Homo sapiens_hsa047202.72688557
6Circadian entrainment_Homo sapiens_hsa047132.60095093
7Glutamatergic synapse_Homo sapiens_hsa047242.59352072
8Morphine addiction_Homo sapiens_hsa050322.49048878
9Olfactory transduction_Homo sapiens_hsa047402.35783231
10Amphetamine addiction_Homo sapiens_hsa050312.34093948
11Salivary secretion_Homo sapiens_hsa049702.25489650
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23487572
13Dopaminergic synapse_Homo sapiens_hsa047282.06976628
14Platelet activation_Homo sapiens_hsa046112.05455479
15Taste transduction_Homo sapiens_hsa047421.92215184
16Gastric acid secretion_Homo sapiens_hsa049711.88370629
17Insulin secretion_Homo sapiens_hsa049111.83091388
18Renin secretion_Homo sapiens_hsa049241.80910454
19Long-term depression_Homo sapiens_hsa047301.79163593
20Cholinergic synapse_Homo sapiens_hsa047251.78669845
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72574655
22Serotonergic synapse_Homo sapiens_hsa047261.71806326
23Calcium signaling pathway_Homo sapiens_hsa040201.66192844
24Oxytocin signaling pathway_Homo sapiens_hsa049211.63434917
25Collecting duct acid secretion_Homo sapiens_hsa049661.60503044
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57230169
27GnRH signaling pathway_Homo sapiens_hsa049121.43983032
28Cocaine addiction_Homo sapiens_hsa050301.43866129
29Phototransduction_Homo sapiens_hsa047441.36485973
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36377386
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33898258
32Gap junction_Homo sapiens_hsa045401.29420643
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27507362
34cAMP signaling pathway_Homo sapiens_hsa040241.25546097
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23312610
36Cardiac muscle contraction_Homo sapiens_hsa042601.23288257
37Estrogen signaling pathway_Homo sapiens_hsa049151.14669334
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13805378
39ECM-receptor interaction_Homo sapiens_hsa045121.13548810
40AMPK signaling pathway_Homo sapiens_hsa041521.13451074
41Axon guidance_Homo sapiens_hsa043601.07841311
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07291341
43Melanogenesis_Homo sapiens_hsa049161.05052419
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04766940
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04205594
46Type II diabetes mellitus_Homo sapiens_hsa049301.02051539
47Glioma_Homo sapiens_hsa052140.99552431
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.98522131
49Focal adhesion_Homo sapiens_hsa045100.97634543
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97103961
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.96758080
52Vibrio cholerae infection_Homo sapiens_hsa051100.95850022
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93639345
54Endometrial cancer_Homo sapiens_hsa052130.92530003
55Pancreatic secretion_Homo sapiens_hsa049720.91473639
56PPAR signaling pathway_Homo sapiens_hsa033200.90147412
57ErbB signaling pathway_Homo sapiens_hsa040120.86616918
58Alzheimers disease_Homo sapiens_hsa050100.81659388
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.81598047
60Insulin resistance_Homo sapiens_hsa049310.80446789
61Thyroid hormone synthesis_Homo sapiens_hsa049180.78662674
62beta-Alanine metabolism_Homo sapiens_hsa004100.78652924
63Dilated cardiomyopathy_Homo sapiens_hsa054140.77608277
64Oocyte meiosis_Homo sapiens_hsa041140.77418268
65Dorso-ventral axis formation_Homo sapiens_hsa043200.76780784
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75893700
67Choline metabolism in cancer_Homo sapiens_hsa052310.74675993
68Tight junction_Homo sapiens_hsa045300.73272060
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71690602
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70877871
71Oxidative phosphorylation_Homo sapiens_hsa001900.69121302
72Arginine and proline metabolism_Homo sapiens_hsa003300.67815721
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67479717
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66361078
75Nitrogen metabolism_Homo sapiens_hsa009100.63832826
76Amoebiasis_Homo sapiens_hsa051460.62584654
77MAPK signaling pathway_Homo sapiens_hsa040100.61132357
78VEGF signaling pathway_Homo sapiens_hsa043700.60770070
79Glucagon signaling pathway_Homo sapiens_hsa049220.59192908
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58890573
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56272490
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55286965
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55217962
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53391749
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53191325
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.52937632
87Ras signaling pathway_Homo sapiens_hsa040140.52832876
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.51064186
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50959785
90Chemokine signaling pathway_Homo sapiens_hsa040620.50834867
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50049866
92Histidine metabolism_Homo sapiens_hsa003400.49801635
93Rap1 signaling pathway_Homo sapiens_hsa040150.49125990
94Inositol phosphate metabolism_Homo sapiens_hsa005620.49019124
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48607233
96African trypanosomiasis_Homo sapiens_hsa051430.46820190
97Glycerolipid metabolism_Homo sapiens_hsa005610.46277981
98FoxO signaling pathway_Homo sapiens_hsa040680.46093763
99Bile secretion_Homo sapiens_hsa049760.43944321
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43857204
101Parkinsons disease_Homo sapiens_hsa050120.41988835
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41268964
103Type I diabetes mellitus_Homo sapiens_hsa049400.40984699
104Wnt signaling pathway_Homo sapiens_hsa043100.40877078
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.40626088
106Acute myeloid leukemia_Homo sapiens_hsa052210.39922834
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39799781
108Fatty acid biosynthesis_Homo sapiens_hsa000610.39166696
109Ovarian steroidogenesis_Homo sapiens_hsa049130.39086899
110Endocytosis_Homo sapiens_hsa041440.38405032
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38389371
112Prion diseases_Homo sapiens_hsa050200.37782803
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37590220
114Circadian rhythm_Homo sapiens_hsa047100.36515681
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36421256
116mTOR signaling pathway_Homo sapiens_hsa041500.36287276
117Renal cell carcinoma_Homo sapiens_hsa052110.35759738
118Alcoholism_Homo sapiens_hsa050340.34841494
119Insulin signaling pathway_Homo sapiens_hsa049100.30613613
120Huntingtons disease_Homo sapiens_hsa050160.30074171
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.29595327
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29022429
123Mineral absorption_Homo sapiens_hsa049780.28822838
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27937442
125Non-small cell lung cancer_Homo sapiens_hsa052230.26641377
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25507426

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