SLC24A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the potassium-dependent sodium/calcium exchanger family and encodes an intracellular membrane protein with 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments. Sequence variation in this gene has been associated with differences in skin pigmentation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pigment cell differentiation (GO:0050931)9.88500470
2melanosome organization (GO:0032438)8.53131198
3pigment granule organization (GO:0048753)8.13426585
4melanin biosynthetic process (GO:0042438)7.69162750
5melanin metabolic process (GO:0006582)7.50151535
6pigment biosynthetic process (GO:0046148)7.15443158
7secondary metabolite biosynthetic process (GO:0044550)6.39408252
8pigment metabolic process (GO:0042440)5.65294499
9endosome to pigment granule transport (GO:0043485)5.47439767
10endosome to melanosome transport (GO:0035646)5.47439767
11pigmentation (GO:0043473)5.00804893
12ketone body metabolic process (GO:1902224)4.85819347
13melanosome transport (GO:0032402)4.30005872
14columnar/cuboidal epithelial cell differentiation (GO:0002065)4.22303856
15establishment of melanosome localization (GO:0032401)4.20969187
16melanosome localization (GO:0032400)4.20858880
17developmental pigmentation (GO:0048066)4.12083455
18positive regulation of neuroblast proliferation (GO:0002052)4.10737627
19pigment granule transport (GO:0051904)4.05319494
20pigment granule localization (GO:0051875)3.99500747
21establishment of pigment granule localization (GO:0051905)3.97749029
22negative regulation of dendrite morphogenesis (GO:0050774)3.92037249
23retinal rod cell development (GO:0046548)3.91895352
24platelet dense granule organization (GO:0060155)3.65676110
25phenol-containing compound metabolic process (GO:0018958)3.64434461
26microtubule depolymerization (GO:0007019)3.62465048
27enteric nervous system development (GO:0048484)3.60854912
28cullin deneddylation (GO:0010388)3.58598637
29cellular response to nitric oxide (GO:0071732)3.53791079
30protein neddylation (GO:0045116)3.44950792
31intraciliary transport (GO:0042073)3.44076116
32DNA ligation (GO:0006266)3.42559252
337-methylguanosine mRNA capping (GO:0006370)3.40013047
34RNA capping (GO:0036260)3.37917849
357-methylguanosine RNA capping (GO:0009452)3.37917849
36cellular response to reactive nitrogen species (GO:1902170)3.32228367
37protein deneddylation (GO:0000338)3.30492873
38proline transport (GO:0015824)3.29898344
39aromatic amino acid family metabolic process (GO:0009072)3.27565124
40regulation of integrin-mediated signaling pathway (GO:2001044)3.26770851
41cerebral cortex radially oriented cell migration (GO:0021799)3.24527009
42proteasome assembly (GO:0043248)3.17376204
43presynaptic membrane assembly (GO:0097105)3.15929128
44kinetochore organization (GO:0051383)3.13226727
45protein-cofactor linkage (GO:0018065)3.12158480
46DNA damage response, detection of DNA damage (GO:0042769)3.09276045
47regulation of mitotic spindle checkpoint (GO:1903504)3.08036791
48regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.08036791
49limb bud formation (GO:0060174)3.07356140
50sympathetic nervous system development (GO:0048485)3.06604395
51cornea development in camera-type eye (GO:0061303)3.05181005
52positive regulation of mitochondrial fission (GO:0090141)3.04779781
53phenol-containing compound biosynthetic process (GO:0046189)3.04712011
54CENP-A containing nucleosome assembly (GO:0034080)3.03519414
55phosphorylated carbohydrate dephosphorylation (GO:0046838)3.00447729
56inositol phosphate dephosphorylation (GO:0046855)3.00447729
57keratinocyte development (GO:0003334)2.99140334
58fusion of sperm to egg plasma membrane (GO:0007342)2.97162748
59myotube differentiation (GO:0014902)2.96846538
60short-chain fatty acid metabolic process (GO:0046459)2.96158643
61DNA double-strand break processing (GO:0000729)2.95766220
62negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.95715411
63acrosome reaction (GO:0007340)2.93383762
64kinetochore assembly (GO:0051382)2.92638209
65peripheral nervous system development (GO:0007422)2.90855537
66deoxyribose phosphate biosynthetic process (GO:0046385)2.90489535
672-deoxyribonucleotide biosynthetic process (GO:0009265)2.90489535
68startle response (GO:0001964)2.88309549
69dopamine transport (GO:0015872)2.87684497
70transcription elongation from RNA polymerase I promoter (GO:0006362)2.87376715
71deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.84627888
72viral mRNA export from host cell nucleus (GO:0046784)2.84062423
73microtubule polymerization or depolymerization (GO:0031109)2.83784486
74negative regulation of dendrite development (GO:2000171)2.82450192
75viral protein processing (GO:0019082)2.81213727
76deoxyribonucleotide biosynthetic process (GO:0009263)2.80930724
77calcium-mediated signaling using intracellular calcium source (GO:0035584)2.80765055
78presynaptic membrane organization (GO:0097090)2.80413762
79pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.77615614
80transcription elongation from RNA polymerase III promoter (GO:0006385)2.76378645
81termination of RNA polymerase III transcription (GO:0006386)2.76378645
82chromatin remodeling at centromere (GO:0031055)2.75928350
83neuroepithelial cell differentiation (GO:0060563)2.75745883
84transcription initiation from RNA polymerase I promoter (GO:0006361)2.75215043
85regulation of early endosome to late endosome transport (GO:2000641)2.74997028
86histone H2A acetylation (GO:0043968)2.72911292
87inositol phosphate catabolic process (GO:0071545)2.72350295
88centrosome duplication (GO:0051298)2.71352122
89transcription from RNA polymerase I promoter (GO:0006360)2.71026538
90chaperone-mediated protein transport (GO:0072321)2.70433701
91protein complex biogenesis (GO:0070271)2.69286292
92guanosine-containing compound biosynthetic process (GO:1901070)2.66337109
93maturation of 5.8S rRNA (GO:0000460)2.65990467
94termination of RNA polymerase I transcription (GO:0006363)2.65869978
95regulation of neuroblast proliferation (GO:1902692)2.65514611
96negative regulation of glycogen biosynthetic process (GO:0045719)2.64657083
97osteoclast differentiation (GO:0030316)2.62515093
98negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.61181727
99negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61102230
100embryonic body morphogenesis (GO:0010172)2.60500306
101regulation of nuclear cell cycle DNA replication (GO:0033262)2.60136155
102negative regulation of mast cell activation (GO:0033004)2.59797288
103neuron cell-cell adhesion (GO:0007158)2.57783598
104negative regulation of transcription by competitive promoter binding (GO:0010944)2.57087798
105sialylation (GO:0097503)2.56081984
106regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54779739
107cellular response to oxygen radical (GO:0071450)2.54762619
108removal of superoxide radicals (GO:0019430)2.54762619
109cellular response to superoxide (GO:0071451)2.54762619
110response to nitric oxide (GO:0071731)2.53688475
111polyol catabolic process (GO:0046174)2.52338454
112nonmotile primary cilium assembly (GO:0035058)2.51570718
113long-chain fatty acid biosynthetic process (GO:0042759)2.51519392
114regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.50075036
115positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.49548450
116secretory granule organization (GO:0033363)2.48747822
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.48270909
118NADH dehydrogenase complex assembly (GO:0010257)2.46964234
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.46964234
120mitochondrial respiratory chain complex I assembly (GO:0032981)2.46964234
121respiratory chain complex IV assembly (GO:0008535)2.46725342
122ER overload response (GO:0006983)2.46427748
123signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.45036341
124signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.45036341
125signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.45036341
126detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44978355
127postsynaptic membrane organization (GO:0001941)2.44814834
128DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.44801221
129signal transduction involved in cell cycle checkpoint (GO:0072395)2.44752623
130transcription elongation from RNA polymerase II promoter (GO:0006368)2.44356622
131transcription-coupled nucleotide-excision repair (GO:0006283)2.43515712
132ganglion development (GO:0061548)2.42901505
133secondary metabolic process (GO:0019748)2.42493708
134regulation of superoxide anion generation (GO:0032928)2.42455360
135protein localization to microtubule (GO:0035372)2.42047890
136mannosylation (GO:0097502)2.41794825
137regulation of pigment cell differentiation (GO:0050932)2.41308568
138negative regulation of interleukin-1 beta production (GO:0032691)2.41180885
139cGMP-mediated signaling (GO:0019934)2.39960827
140cell differentiation involved in metanephros development (GO:0072202)2.39816748
141signal peptide processing (GO:0006465)2.37742286
142signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.37298430
143intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.37298430
144protein localization to microtubule cytoskeleton (GO:0072698)2.37180110
145centriole replication (GO:0007099)2.36855504
146cytochrome complex assembly (GO:0017004)2.35757506
147negative regulation of signal transduction by p53 class mediator (GO:1901797)2.35251201
148plasma membrane fusion (GO:0045026)2.34997745
149negative regulation of glycogen metabolic process (GO:0070874)2.34996205
150negative regulation of macroautophagy (GO:0016242)2.34629077
151positive regulation of amino acid transport (GO:0051957)2.34437558
152mitochondrial respiratory chain complex assembly (GO:0033108)2.33676957
153vesicle localization (GO:0051648)2.33463362
154DNA-templated transcription, elongation (GO:0006354)2.33431794
155centriole assembly (GO:0098534)2.32973130
156GTP biosynthetic process (GO:0006183)2.32718680
157negative regulation of JUN kinase activity (GO:0043508)2.32414974
158RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.31897808
159tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.31897808
160negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.29383961
161negative regulation of organelle assembly (GO:1902116)2.27786244
162piRNA metabolic process (GO:0034587)2.26516899
163mitotic G1 DNA damage checkpoint (GO:0031571)2.24076247
164response to pheromone (GO:0019236)2.21938259
165intracellular pH reduction (GO:0051452)2.17329956
166cranial nerve development (GO:0021545)2.17298468
167regulation of protein sumoylation (GO:0033233)2.17010250
168positive regulation of cellular response to oxidative stress (GO:1900409)2.16172799
169positive regulation of response to oxidative stress (GO:1902884)2.16172799
170astrocyte differentiation (GO:0048708)2.14997661
171positive regulation of neural precursor cell proliferation (GO:2000179)2.12470490
172G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.10961491
173negative regulation of chemokine production (GO:0032682)2.10767543
174positive regulation of receptor recycling (GO:0001921)2.09114701
175synaptic transmission, cholinergic (GO:0007271)2.08717710
176dendritic spine organization (GO:0097061)2.07076658
177regulation of penile erection (GO:0060405)2.05693455
178alanine transport (GO:0032328)2.05536578
179mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.03789609
180behavioral response to ethanol (GO:0048149)2.03398665
181neural crest cell migration (GO:0001755)2.02639708
182layer formation in cerebral cortex (GO:0021819)2.02405782
183body morphogenesis (GO:0010171)2.02146913
184melanocyte differentiation (GO:0030318)10.1909497
185tyrosine metabolic process (GO:0006570)10.0025587
186basement membrane organization (GO:0071711)1.98889491
187dopamine biosynthetic process (GO:0042416)1.98768596
188neuron remodeling (GO:0016322)1.98675076
189regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.98316281

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.93241975
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34906493
3GBX2_23144817_ChIP-Seq_PC3_Human3.20995195
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.17070814
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.49171434
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39424009
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39374469
8EZH2_22144423_ChIP-Seq_EOC_Human2.35365374
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32797868
10* MITF_21258399_ChIP-Seq_MELANOMA_Human2.19921188
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18170288
12TAF15_26573619_Chip-Seq_HEK293_Human2.16159047
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.15003559
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07851642
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07455148
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07319371
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01577478
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.00038863
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.96294787
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94415640
21FUS_26573619_Chip-Seq_HEK293_Human1.92274764
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.88196566
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88188769
24* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.86331734
25E2F7_22180533_ChIP-Seq_HELA_Human1.85429492
26EWS_26573619_Chip-Seq_HEK293_Human1.84346479
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83147424
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77344615
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76408243
30IGF1R_20145208_ChIP-Seq_DFB_Human1.75281187
31ELK1_19687146_ChIP-ChIP_HELA_Human1.73482424
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72932760
33RNF2_27304074_Chip-Seq_NSC_Mouse1.71737470
34P300_19829295_ChIP-Seq_ESCs_Human1.71327503
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70407516
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.68083891
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67481676
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.67417858
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67400045
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.66911392
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.66294554
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65990458
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61237735
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60885996
45VDR_22108803_ChIP-Seq_LS180_Human1.60504218
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57206328
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55368716
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54270346
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.53005581
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52640701
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52501064
52TFEB_21752829_ChIP-Seq_HELA_Human1.50484763
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49432567
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48307043
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47123493
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46483362
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46483362
58SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.45693545
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45626790
60IRF1_19129219_ChIP-ChIP_H3396_Human1.45049472
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43544486
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43046775
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42456568
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42445362
65AR_25329375_ChIP-Seq_VCAP_Human1.38393792
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.37009131
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36816102
68FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.35823709
69GATA1_22025678_ChIP-Seq_K562_Human1.35738517
70AR_21572438_ChIP-Seq_LNCaP_Human1.35285416
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.33232268
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31782499
73* TCF4_23295773_ChIP-Seq_U87_Human1.31469516
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30820150
75* ER_23166858_ChIP-Seq_MCF-7_Human1.29603980
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29283497
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29160231
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29044650
79SMAD3_21741376_ChIP-Seq_ESCs_Human1.28927836
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28874398
81* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28325444
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27706788
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26700067
84CBP_20019798_ChIP-Seq_JUKART_Human1.26256628
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26256628
86* NANOG_18555785_Chip-Seq_ESCs_Mouse1.25973459
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24534083
88ETS1_20019798_ChIP-Seq_JURKAT_Human1.24442937
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24346559
90* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24264764
91* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22670759
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22536838
93VDR_23849224_ChIP-Seq_CD4+_Human1.21311778
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.20468265
95SMAD4_21799915_ChIP-Seq_A2780_Human1.20341107
96* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20094847
97* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18444562
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.18067662
99* P53_22387025_ChIP-Seq_ESCs_Mouse1.17192792
100FOXM1_23109430_ChIP-Seq_U2OS_Human1.16420654
101* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16293347
102* SOX9_26525672_Chip-Seq_HEART_Mouse1.16104344
103MYC_18940864_ChIP-ChIP_HL60_Human1.16080572
104* E2F1_18555785_Chip-Seq_ESCs_Mouse1.15556553
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.15318165
106JUN_21703547_ChIP-Seq_K562_Human1.15196976
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14933763
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14923473
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14832927
110EZH2_27304074_Chip-Seq_ESCs_Mouse1.14772649
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14018778
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13904070
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13838710
114* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12911548
115ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12428375
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12162701
117ZNF274_21170338_ChIP-Seq_K562_Hela1.11911082
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11371436
119WT1_19549856_ChIP-ChIP_CCG9911_Human1.11059012
120* STAT3_18555785_Chip-Seq_ESCs_Mouse1.08692764
121* CTCF_18555785_Chip-Seq_ESCs_Mouse1.08029857
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.07510822
123* P300_18555785_Chip-Seq_ESCs_Mouse1.06925109
124* STAT3_23295773_ChIP-Seq_U87_Human1.06542408
125TCF4_22108803_ChIP-Seq_LS180_Human1.06023437
126RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05197167
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.05004345
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04958123
129* CMYC_18555785_Chip-Seq_ESCs_Mouse1.03194746
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02721687
131* OCT4_18555785_Chip-Seq_ESCs_Mouse1.02221270
132HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01886760
133* NMYC_18555785_Chip-Seq_ESCs_Mouse1.01357193
134STAT3_18555785_ChIP-Seq_MESCs_Mouse1.00727634
135* KLF4_18555785_Chip-Seq_ESCs_Mouse0.99785103
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99429800
137TAL1_26923725_Chip-Seq_HPCs_Mouse0.99379066
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98190768
139UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97989319
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97887723
141FOXP3_21729870_ChIP-Seq_TREG_Human0.97824461
142SMAD4_21741376_ChIP-Seq_EPCs_Human0.96883309
143* ZFX_18555785_Chip-Seq_ESCs_Mouse0.96256732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation6.02339607
2MP0005171_absent_coat_pigmentation5.63647832
3MP0003136_yellow_coat_color3.10639069
4MP0001188_hyperpigmentation3.02160457
5MP0002877_abnormal_melanocyte_morpholog2.84862512
6MP0006292_abnormal_olfactory_placode2.84576955
7MP0003787_abnormal_imprinting2.53898517
8* MP0005408_hypopigmentation2.52618194
9MP0003880_abnormal_central_pattern2.44630453
10MP0000566_synostosis2.13703233
11* MP0000015_abnormal_ear_pigmentation2.07085091
12MP0002102_abnormal_ear_morphology1.99815657
13MP0001529_abnormal_vocalization1.94388957
14MP0005409_darkened_coat_color1.94071770
15MP0002938_white_spotting1.90415710
16MP0004381_abnormal_hair_follicle1.88668585
17* MP0002095_abnormal_skin_pigmentation1.86859459
18MP0002751_abnormal_autonomic_nervous1.81219285
19MP0008789_abnormal_olfactory_epithelium1.79542804
20MP0005646_abnormal_pituitary_gland1.79097887
21MP0009697_abnormal_copulation1.73878235
22MP0005645_abnormal_hypothalamus_physiol1.73766447
23MP0003121_genomic_imprinting1.68524626
24MP0010094_abnormal_chromosome_stability1.68494481
25MP0002638_abnormal_pupillary_reflex1.64307280
26MP0006276_abnormal_autonomic_nervous1.62412165
27MP0000371_diluted_coat_color1.62118293
28MP0005394_taste/olfaction_phenotype1.61187179
29MP0005499_abnormal_olfactory_system1.61187179
30MP0003122_maternal_imprinting1.60468387
31MP0003718_maternal_effect1.59183879
32MP0008058_abnormal_DNA_repair1.56472249
33MP0003315_abnormal_perineum_morphology1.53374603
34MP0000778_abnormal_nervous_system1.50032622
35MP0008007_abnormal_cellular_replicative1.41878943
36MP0002090_abnormal_vision1.41703277
37MP0002075_abnormal_coat/hair_pigmentati1.41245201
38MP0008877_abnormal_DNA_methylation1.41082496
39MP0001984_abnormal_olfaction1.38096773
40* MP0001186_pigmentation_phenotype1.37247926
41MP0005174_abnormal_tail_pigmentation1.35780138
42MP0001986_abnormal_taste_sensitivity1.34633838
43MP0001905_abnormal_dopamine_level1.31931292
44MP0005257_abnormal_intraocular_pressure1.29192767
45MP0000631_abnormal_neuroendocrine_gland1.27186804
46MP0002876_abnormal_thyroid_physiology1.24784872
47MP0000049_abnormal_middle_ear1.22127582
48MP0003786_premature_aging1.21602414
49MP0003111_abnormal_nucleus_morphology1.21129526
50MP0005367_renal/urinary_system_phenotyp1.20299949
51MP0000516_abnormal_urinary_system1.20299949
52MP0001485_abnormal_pinna_reflex1.18251622
53MP0002160_abnormal_reproductive_system1.16841399
54MP0000569_abnormal_digit_pigmentation1.12795737
55MP0003693_abnormal_embryo_hatching1.12366120
56MP0009745_abnormal_behavioral_response1.10296010
57MP0009046_muscle_twitch1.07749873
58MP0005389_reproductive_system_phenotype1.07010508
59MP0002184_abnormal_innervation1.06085296
60MP0002572_abnormal_emotion/affect_behav1.05753278
61MP0008057_abnormal_DNA_replication1.05631275
62MP0002557_abnormal_social/conspecific_i1.04754024
63MP0004885_abnormal_endolymph1.04366162
64MP0002736_abnormal_nociception_after1.04271431
65MP0002735_abnormal_chemical_nociception1.04191176
66MP0001177_atelectasis1.02528228
67MP0001919_abnormal_reproductive_system1.02275466
68* MP0001324_abnormal_eye_pigmentation1.01285926
69MP0003878_abnormal_ear_physiology1.01049266
70MP0005377_hearing/vestibular/ear_phenot1.01049266
71MP0001963_abnormal_hearing_physiology1.00872817
72MP0002063_abnormal_learning/memory/cond1.00201874
73MP0001968_abnormal_touch/_nociception0.98849194
74MP0000026_abnormal_inner_ear0.98660537
75* MP0005075_abnormal_melanosome_morpholog0.98492634
76MP0002734_abnormal_mechanical_nocicepti0.98352538
77MP0003077_abnormal_cell_cycle0.98332225
78MP0008260_abnormal_autophagy0.97549641
79MP0003806_abnormal_nucleotide_metabolis0.95984753
80* MP0005197_abnormal_uvea_morphology0.95918747
81MP0004924_abnormal_behavior0.94852294
82MP0005386_behavior/neurological_phenoty0.94852294
83MP0005253_abnormal_eye_physiology0.92256273
84MP0000681_abnormal_thyroid_gland0.92113821
85MP0008932_abnormal_embryonic_tissue0.91912361
86MP0002822_catalepsy0.91488087
87MP0004142_abnormal_muscle_tone0.90263893
88MP0002067_abnormal_sensory_capabilities0.89822160
89MP0003938_abnormal_ear_development0.89256553
90MP0002272_abnormal_nervous_system0.88556515
91MP0010386_abnormal_urinary_bladder0.88448019
92MP0003172_abnormal_lysosome_physiology0.85563525
93MP0003635_abnormal_synaptic_transmissio0.85103448
94MP0001486_abnormal_startle_reflex0.84969595
95MP0002064_seizures0.83600333
96MP0004782_abnormal_surfactant_physiolog0.81358016
97MP0009379_abnormal_foot_pigmentation0.80899371
98MP0004147_increased_porphyrin_level0.80861353
99MP0010234_abnormal_vibrissa_follicle0.80646414
100MP0005248_abnormal_Harderian_gland0.79533511
101MP0005551_abnormal_eye_electrophysiolog0.78521217
102* MP0002177_abnormal_outer_ear0.77539793
103MP0002163_abnormal_gland_morphology0.77107295
104MP0003385_abnormal_body_wall0.74949135
105MP0003890_abnormal_embryonic-extraembry0.72224117
106MP0002752_abnormal_somatic_nervous0.71418305
107MP0003937_abnormal_limbs/digits/tail_de0.70791594
108MP0004270_analgesia0.70677279
109MP0005058_abnormal_lysosome_morphology0.63400079
110MP0003646_muscle_fatigue0.55496578
111MP0000367_abnormal_coat/_hair0.51373717
112MP0005187_abnormal_penis_morphology0.50497364
113MP0005391_vision/eye_phenotype0.46278584
114MP0002837_dystrophic_cardiac_calcinosis0.41197256
115MP0001293_anophthalmia0.40743358
116MP0003186_abnormal_redox_activity0.36514152
117MP0000377_abnormal_hair_follicle0.35274233
118MP0000647_abnormal_sebaceous_gland0.35221778
119MP0002229_neurodegeneration0.34289470
120* MP0005193_abnormal_anterior_eye0.33706498
121MP0002089_abnormal_postnatal_growth/wei0.30963859
122MP0003567_abnormal_fetal_cardiomyocyte0.30638195
123MP0010030_abnormal_orbit_morphology0.30506085
124MP0003283_abnormal_digestive_organ0.30007754
125* MP0005195_abnormal_posterior_eye0.26532140
126MP0002092_abnormal_eye_morphology0.25624989
127MP0000920_abnormal_myelination0.23519817
128MP0002909_abnormal_adrenal_gland0.23046112
129MP0003011_delayed_dark_adaptation0.21896120
130MP0005423_abnormal_somatic_nervous0.21367897
131MP0002697_abnormal_eye_size0.21286685
132MP0008569_lethality_at_weaning0.21214856
133MP0000749_muscle_degeneration0.21091496
134MP0003632_abnormal_nervous_system0.17743881
135MP0000358_abnormal_cell_content/0.17392382
136MP0003634_abnormal_glial_cell0.15775329
137MP0008770_decreased_survivor_rate0.15183890
138MP0008438_abnormal_cutaneous_collagen0.15106954
139MP0003698_abnormal_male_reproductive0.13835262
140MP0000427_abnormal_hair_cycle0.12462541
141MP0001299_abnormal_eye_distance/0.12311029
142MP0002233_abnormal_nose_morphology0.12212388
143MP0002109_abnormal_limb_morphology0.11038007
144MP0004133_heterotaxia0.10350136
145MP0000955_abnormal_spinal_cord0.10258385
146MP0006138_congestive_heart_failure0.09673963
147MP0004742_abnormal_vestibular_system0.09569699
148MP0003950_abnormal_plasma_membrane0.09188112

Predicted human phenotypes

RankGene SetZ-score
1Hypopigmentation of the fundus (HP:0007894)6.59933169
2Albinism (HP:0001022)6.03078660
3Abnormal auditory evoked potentials (HP:0006958)4.64774879
4Aplasia/Hypoplasia of the fovea (HP:0008060)4.38991704
5Hypoplasia of the fovea (HP:0007750)4.38991704
6Hypothermia (HP:0002045)4.03288486
7Hypoplasia of the iris (HP:0007676)3.86813131
8Blue irides (HP:0000635)3.80698014
9Abnormality of the fovea (HP:0000493)3.79398724
10Cutaneous melanoma (HP:0012056)3.68204378
11Abnormal hair whorl (HP:0010721)3.67049483
12Aplasia/Hypoplasia of the macula (HP:0008059)3.62446585
13Pancreatic fibrosis (HP:0100732)3.42986786
14Medial flaring of the eyebrow (HP:0010747)3.27918960
15Nephrogenic diabetes insipidus (HP:0009806)3.22065229
16Aplasia/Hypoplasia affecting the retina (HP:0008061)3.14991358
17Gait imbalance (HP:0002141)3.14073824
18True hermaphroditism (HP:0010459)3.12872410
19Congenital primary aphakia (HP:0007707)3.08893763
20Bilateral sensorineural hearing impairment (HP:0008619)2.90586085
21White forelock (HP:0002211)2.82873968
22Poor coordination (HP:0002370)2.74658582
23Patchy hypopigmentation of hair (HP:0011365)2.68322081
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66464978
25Pancreatic cysts (HP:0001737)2.64823131
26Spastic paraparesis (HP:0002313)2.62705225
27Acute necrotizing encephalopathy (HP:0006965)2.60127187
28Heterochromia iridis (HP:0001100)2.59724960
29Preaxial hand polydactyly (HP:0001177)2.51471913
30Febrile seizures (HP:0002373)2.47400054
31Genital tract atresia (HP:0001827)2.41201201
32Intestinal atresia (HP:0011100)2.40434815
33Birth length less than 3rd percentile (HP:0003561)2.38703133
34Vaginal atresia (HP:0000148)2.36329763
35Chromsome breakage (HP:0040012)2.35757583
36Abnormality of the labia minora (HP:0012880)2.34851825
37Nephroblastoma (Wilms tumor) (HP:0002667)2.32297723
38Type I transferrin isoform profile (HP:0003642)2.31882551
39Peripheral hypomyelination (HP:0007182)2.31754218
40Congenital sensorineural hearing impairment (HP:0008527)2.31172737
41Patellar aplasia (HP:0006443)2.30784612
42Embryonal renal neoplasm (HP:0011794)2.30104027
43Atonic seizures (HP:0010819)2.29126900
44Progressive macrocephaly (HP:0004481)2.26501399
45Hyperventilation (HP:0002883)2.26291874
46Abnormal lung lobation (HP:0002101)2.24722576
47Amblyopia (HP:0000646)2.22985306
48Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.20246595
49Aplasia/Hypoplasia of the patella (HP:0006498)2.19401530
50Generalized hypopigmentation of hair (HP:0011358)2.18961434
51Protruding tongue (HP:0010808)2.18928617
52Aganglionic megacolon (HP:0002251)2.18726234
53Congenital stationary night blindness (HP:0007642)2.18191146
54Postaxial foot polydactyly (HP:0001830)2.17599913
55Osteomalacia (HP:0002749)2.16812400
56Chronic hepatic failure (HP:0100626)2.14096508
57Focal motor seizures (HP:0011153)2.12753066
58Abnormal mitochondria in muscle tissue (HP:0008316)2.11546365
59Molar tooth sign on MRI (HP:0002419)2.11375677
60Abnormality of midbrain morphology (HP:0002418)2.11375677
61Premature graying of hair (HP:0002216)2.11119992
62Degeneration of anterior horn cells (HP:0002398)1.98873246
63Abnormality of the anterior horn cell (HP:0006802)1.98873246
64Occipital encephalocele (HP:0002085)1.98289000
65Large for gestational age (HP:0001520)1.97938404
66Mitochondrial inheritance (HP:0001427)1.96866373
67Iris hypopigmentation (HP:0007730)1.95060036
68Abnormality of incisor morphology (HP:0011063)1.94922995
69Paraparesis (HP:0002385)1.93564394
70Increased CSF lactate (HP:0002490)1.93555626
713-Methylglutaconic aciduria (HP:0003535)1.93043602
72Renal Fanconi syndrome (HP:0001994)1.92862493
73Rectovaginal fistula (HP:0000143)1.92553898
74Rectal fistula (HP:0100590)1.92553898
75Aplasia/Hypoplasia of the tibia (HP:0005772)1.92308015
76Epileptic encephalopathy (HP:0200134)1.91885836
77Synophrys (HP:0000664)1.91432054
78Generalized hypopigmentation (HP:0007513)1.90957744
79Optic nerve coloboma (HP:0000588)1.88909496
80Supernumerary spleens (HP:0009799)1.85953956
81Adrenal hypoplasia (HP:0000835)1.85567991
82Decreased central vision (HP:0007663)1.85389177
83Asymmetry of the thorax (HP:0001555)1.85315716
84Aplasia/Hypoplasia of the lens (HP:0008063)1.84350379
85Papillary thyroid carcinoma (HP:0002895)1.83744162
86Absent eyebrow (HP:0002223)1.83136531
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81057134
88Morphological abnormality of the middle ear (HP:0008609)1.80447444
89Tubulointerstitial nephritis (HP:0001970)1.79309082
90Optic nerve hypoplasia (HP:0000609)1.77390174
91Limb dystonia (HP:0002451)1.76500843
92Impulsivity (HP:0100710)1.76103267
93Lissencephaly (HP:0001339)1.76021705
94Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75914048
95Chorioretinal coloboma (HP:0000567)1.75823768
96Nephronophthisis (HP:0000090)1.75559417
97Short tibia (HP:0005736)1.74756240
98Cerebral hypomyelination (HP:0006808)1.73400680
99Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73386931
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.73322083
101Carpal bone hypoplasia (HP:0001498)1.73197319
102Morphological abnormality of the inner ear (HP:0011390)1.72708151
103Type 2 muscle fiber atrophy (HP:0003554)1.72022923
104Abnormality of the metopic suture (HP:0005556)1.71834653
105Increased hepatocellular lipid droplets (HP:0006565)1.71554335
106Abnormality of hair growth rate (HP:0011363)1.71403850
107Slow-growing hair (HP:0002217)1.71403850
108Septo-optic dysplasia (HP:0100842)1.71384849
109Intestinal fistula (HP:0100819)1.71146261
110Thyroid carcinoma (HP:0002890)1.71041964
111Abnormal respiratory epithelium morphology (HP:0012253)1.70623585
112Abnormal respiratory motile cilium morphology (HP:0005938)1.70623585
113Broad foot (HP:0001769)1.70268905
114Postaxial hand polydactyly (HP:0001162)1.70105983
115Facial cleft (HP:0002006)1.67737328
116Astigmatism (HP:0000483)1.67359009
117Acute encephalopathy (HP:0006846)1.66135717
118Ocular albinism (HP:0001107)1.65611795
119Freckling (HP:0001480)1.65361023
120Melanoma (HP:0002861)1.63946645
121Poor head control (HP:0002421)1.61965420
122Spinal muscular atrophy (HP:0007269)1.60457527
123Abnormality of vision evoked potentials (HP:0000649)1.59382469
124Underdeveloped nasal alae (HP:0000430)1.58150947
125Lip pit (HP:0100267)1.57662251
126Megalencephaly (HP:0001355)1.56721864
127Alacrima (HP:0000522)1.52981931
128Aplasia cutis congenita (HP:0001057)1.52103687
129Abnormality of liposaccharide metabolism (HP:0010968)1.44167816
130Abnormality of glycosphingolipid metabolism (HP:0004343)1.44167816
131Abnormality of glycolipid metabolism (HP:0010969)1.44167816
132Abnormal autonomic nervous system physiology (HP:0012332)1.38655865
133Horizontal nystagmus (HP:0000666)1.34450983
134Melanocytic nevus (HP:0000995)1.33311197
135Leukodystrophy (HP:0002415)1.33109985
136Abnormality of the nasal septum (HP:0000419)1.31805092
137Cerebral inclusion bodies (HP:0100314)1.30136087
138Ulnar claw (HP:0001178)1.28088659
139Fibular hypoplasia (HP:0003038)1.27303499
140Median cleft lip (HP:0000161)1.25781009
141Decreased lacrimation (HP:0000633)1.23884512
142Frequent falls (HP:0002359)1.19232186
143Visual hallucinations (HP:0002367)1.17954111
144Abnormality of the corticospinal tract (HP:0002492)1.14563167
145Upper limb muscle weakness (HP:0003484)1.12873205
146* Photophobia (HP:0000613)1.09427640
147Epidermoid cyst (HP:0200040)1.07235338
148Akinesia (HP:0002304)1.06918495
149Action tremor (HP:0002345)1.06092039
150Decreased motor nerve conduction velocity (HP:0003431)1.05275733
151Supernumerary nipples (HP:0002558)1.04967707
152Anophthalmia (HP:0000528)1.04743080
153Neoplasm of the oral cavity (HP:0100649)1.03943843
154Tongue fasciculations (HP:0001308)1.02088930
155Telecanthus (HP:0000506)1.01366390
156Nasal speech (HP:0001611)1.01146030
157Wide intermamillary distance (HP:0006610)0.99928640
158Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)0.98338229
159Degeneration of the lateral corticospinal tracts (HP:0002314)0.98338229
160Hypopigmented skin patches (HP:0001053)0.98190957
161Hamartoma of the eye (HP:0010568)0.97338416
162Abnormality of the anterior chamber (HP:0000593)0.96816015
163Hypermetropia (HP:0000540)0.95787058
164Intestinal polyposis (HP:0200008)0.94509902
165Neoplasm of the peripheral nervous system (HP:0100007)0.92912323
166Vertebral compression fractures (HP:0002953)0.92496501
167Hypermelanotic macule (HP:0001034)0.91365468
168Long clavicles (HP:0000890)0.90556716
169Postural tremor (HP:0002174)0.89768880
170Intestinal polyp (HP:0005266)0.87542094
171Nasolacrimal duct obstruction (HP:0000579)0.86527080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.42834062
2PDK23.68119689
3AKT33.34982991
4SRPK12.78382582
5CCNB12.46416525
6SGK22.39078364
7ERBB32.31914264
8MKNK22.31357685
9YES12.28617725
10ZAK2.26332479
11MKNK12.24296357
12MAPK132.22543123
13STK162.19904567
14FER2.06236374
15MAP2K72.05736196
16ACVR1B2.04644512
17PLK22.03782906
18PRPF4B2.03291819
19BMPR22.01842616
20MAP3K31.97430672
21PLK31.90554400
22FGFR21.88718977
23SIK31.84119336
24PRKCH1.80528709
25PNCK1.77069594
26PLK41.68608299
27SGK2231.65995028
28SGK4941.65995028
29BUB11.65334559
30TRIM281.59186920
31BMPR1B1.57940713
32MST1R1.54337078
33VRK11.50955345
34MARK11.46879781
35EIF2AK11.44313399
36BRAF1.43835691
37CDK81.40574107
38NUAK11.40215200
39BCR1.36992563
40EPHA41.34594880
41GSK3A1.30885382
42MAP3K21.27336252
43WEE11.25781272
44SGK31.23527107
45DYRK21.22741983
46EIF2AK21.22272164
47DDR21.21699961
48EIF2AK31.20346086
49BRSK21.19723890
50STK38L1.18344873
51TGFBR11.15594367
52ADRBK21.13362116
53PTK2B1.12216434
54NEK61.08689940
55TYRO31.07562708
56CDK31.06784776
57ERBB21.05329054
58TSSK61.03589828
59BRSK11.02468362
60LATS11.02132359
61GRK71.00078997
62PINK10.96511197
63STK30.95963317
64FGFR10.95137569
65PRKD10.94916361
66CDK70.94540894
67NTRK20.91720706
68MAPKAPK30.91551599
69MARK30.91329782
70PRKD30.87417529
71TNIK0.85652322
72ABL20.85510185
73NME20.84354908
74STK240.83308190
75NEK20.83188317
76MAP3K120.82815529
77IRAK30.81937684
78AURKA0.81020691
79PAK40.80388342
80AKT20.79539227
81IRAK40.77048642
82MAP3K60.76579199
83MUSK0.76457116
84CHEK20.73909575
85PLK10.72034331
86MAP3K140.71913598
87LMTK20.70981199
88ADRBK10.69928432
89CSNK1G30.69487729
90FGR0.67103709
91NEK10.66285393
92PRKCE0.64308618
93PAK60.62308239
94NME10.61727857
95CDC70.61523132
96DYRK1A0.61068368
97TXK0.60324678
98PTK60.60120003
99NTRK30.59202781
100RPS6KB10.57899752
101UHMK10.57414611
102PKN10.57334452
103PRKCG0.56741389
104PAK30.56219193
105GRK60.55325257
106MATK0.54974164
107RPS6KC10.54933951
108RPS6KL10.54933951
109ARAF0.51440193
110MINK10.51081009
111RPS6KA60.50194826
112MET0.49732646
113CSNK1G20.49728088
114CSNK1G10.49579073
115INSRR0.49072403
116FRK0.48405068
117TGFBR20.47781570
118OXSR10.47720480
119RPS6KA20.46677406
120CAMK2B0.45814765
121EPHA30.45649890
122WNK30.45121072
123CSNK1D0.44839400
124TIE10.44721916
125TAF10.44675699
126PRKACB0.44480692
127CSNK2A10.43822017
128MAP3K40.42917586
129MAP2K10.41850630
130CSNK1A1L0.41687354
131PBK0.41413920
132GRK50.40622763
133CDK60.40307639
134TAOK20.39072500
135DAPK10.37579849
136CDK180.36815651
137MAPKAPK50.36435982
138RPS6KA50.36173829
139TNK20.35636391
140CSNK1A10.35385494
141ATM0.34899790
142MAP3K110.34447713
143KIT0.33366496
144CAMK2A0.33247962
145ATR0.32731213
146IRAK20.32578287
147CLK10.32243174
148MYLK0.32079612
149PRKAA20.31755380
150GRK10.31544031
151SGK10.31251255
152CDK140.31113498
153CDK150.30666949
154ERBB40.29433017
155ICK0.29255386
156CHUK0.28008583
157CDK11A0.27402791

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.72239250
2RNA polymerase_Homo sapiens_hsa030203.17616724
3Basal transcription factors_Homo sapiens_hsa030222.68527993
4Mismatch repair_Homo sapiens_hsa034302.27139627
5Fanconi anemia pathway_Homo sapiens_hsa034602.26202601
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26015908
7Protein export_Homo sapiens_hsa030602.22546803
8Homologous recombination_Homo sapiens_hsa034402.22214234
9Oxidative phosphorylation_Homo sapiens_hsa001902.21754909
10Nicotine addiction_Homo sapiens_hsa050332.15150972
11Base excision repair_Homo sapiens_hsa034102.08869235
12Spliceosome_Homo sapiens_hsa030402.07661823
13Nucleotide excision repair_Homo sapiens_hsa034202.02107091
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96885096
15RNA degradation_Homo sapiens_hsa030181.95312639
16Parkinsons disease_Homo sapiens_hsa050121.88736690
17Pyrimidine metabolism_Homo sapiens_hsa002401.87254223
18DNA replication_Homo sapiens_hsa030301.80842977
19Cell cycle_Homo sapiens_hsa041101.74952372
20Huntingtons disease_Homo sapiens_hsa050161.72851511
21Non-homologous end-joining_Homo sapiens_hsa034501.66381713
22Collecting duct acid secretion_Homo sapiens_hsa049661.65792852
23RNA transport_Homo sapiens_hsa030131.61747332
24Ribosome_Homo sapiens_hsa030101.60081350
25Phototransduction_Homo sapiens_hsa047441.59032567
26Lysosome_Homo sapiens_hsa041421.58162130
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57357539
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.51981832
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51195167
30Purine metabolism_Homo sapiens_hsa002301.48959326
31Tyrosine metabolism_Homo sapiens_hsa003501.45123179
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43183121
33mRNA surveillance pathway_Homo sapiens_hsa030151.41213773
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.39755257
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39236886
36Alzheimers disease_Homo sapiens_hsa050101.35188745
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35024067
38Propanoate metabolism_Homo sapiens_hsa006401.33100385
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31313164
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28938923
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.28672109
42Arachidonic acid metabolism_Homo sapiens_hsa005901.23901713
43Serotonergic synapse_Homo sapiens_hsa047261.20620064
44Regulation of autophagy_Homo sapiens_hsa041401.19618338
45Synaptic vesicle cycle_Homo sapiens_hsa047211.15677114
46Olfactory transduction_Homo sapiens_hsa047401.14156860
47Taste transduction_Homo sapiens_hsa047421.13125475
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.10716218
49Vibrio cholerae infection_Homo sapiens_hsa051101.07618449
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07575584
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04524231
52Adherens junction_Homo sapiens_hsa045201.03568476
53Vitamin B6 metabolism_Homo sapiens_hsa007501.00796875
54Folate biosynthesis_Homo sapiens_hsa007900.97634520
55Inositol phosphate metabolism_Homo sapiens_hsa005620.95485111
56ABC transporters_Homo sapiens_hsa020100.94138638
57Nitrogen metabolism_Homo sapiens_hsa009100.92541947
58Epstein-Barr virus infection_Homo sapiens_hsa051690.89938745
59Axon guidance_Homo sapiens_hsa043600.88369722
60Oocyte meiosis_Homo sapiens_hsa041140.86988685
61Morphine addiction_Homo sapiens_hsa050320.86943081
62Small cell lung cancer_Homo sapiens_hsa052220.86460225
63Cardiac muscle contraction_Homo sapiens_hsa042600.85572415
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83167310
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81279678
66Histidine metabolism_Homo sapiens_hsa003400.81274300
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78445202
68One carbon pool by folate_Homo sapiens_hsa006700.76802774
69Other glycan degradation_Homo sapiens_hsa005110.76719305
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75280072
71Glutathione metabolism_Homo sapiens_hsa004800.75032356
72Amphetamine addiction_Homo sapiens_hsa050310.74597002
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72878926
74GABAergic synapse_Homo sapiens_hsa047270.72654232
75Ether lipid metabolism_Homo sapiens_hsa005650.70416734
76Dorso-ventral axis formation_Homo sapiens_hsa043200.70414714
77Rheumatoid arthritis_Homo sapiens_hsa053230.70139012
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68368596
79Dopaminergic synapse_Homo sapiens_hsa047280.68247723
80Autoimmune thyroid disease_Homo sapiens_hsa053200.67306741
81Melanoma_Homo sapiens_hsa052180.66671470
82Glutamatergic synapse_Homo sapiens_hsa047240.66453575
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65050756
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63488285
85Melanogenesis_Homo sapiens_hsa049160.63098061
86Alcoholism_Homo sapiens_hsa050340.62481273
87Pyruvate metabolism_Homo sapiens_hsa006200.60669274
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60506635
89Phagosome_Homo sapiens_hsa041450.60135608
90Butanoate metabolism_Homo sapiens_hsa006500.59718387
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59013906
92Sphingolipid metabolism_Homo sapiens_hsa006000.58787569
93Type I diabetes mellitus_Homo sapiens_hsa049400.57135043
94Steroid biosynthesis_Homo sapiens_hsa001000.56325538
95Circadian entrainment_Homo sapiens_hsa047130.55469751
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54847822
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54676077
98Fatty acid elongation_Homo sapiens_hsa000620.52053572
99Linoleic acid metabolism_Homo sapiens_hsa005910.51825093
100Pentose phosphate pathway_Homo sapiens_hsa000300.51401155
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51134196
102Vitamin digestion and absorption_Homo sapiens_hsa049770.50371560
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49786849
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49062819
105Long-term potentiation_Homo sapiens_hsa047200.48670560
106Chemical carcinogenesis_Homo sapiens_hsa052040.47106680
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46599112
108Hippo signaling pathway_Homo sapiens_hsa043900.45821743
109Metabolic pathways_Homo sapiens_hsa011000.45354660
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44871621
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44401179
112Long-term depression_Homo sapiens_hsa047300.44321457
113p53 signaling pathway_Homo sapiens_hsa041150.44067507
114Peroxisome_Homo sapiens_hsa041460.40563009
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40552000
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40360770
117Selenocompound metabolism_Homo sapiens_hsa004500.39874069
118Wnt signaling pathway_Homo sapiens_hsa043100.39659845
119Prostate cancer_Homo sapiens_hsa052150.36983033
120N-Glycan biosynthesis_Homo sapiens_hsa005100.36850667
121Fatty acid metabolism_Homo sapiens_hsa012120.36014352
122Cocaine addiction_Homo sapiens_hsa050300.35966110
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35662784
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34700206
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34162265
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33245633
127Endometrial cancer_Homo sapiens_hsa052130.33178974
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32217046
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.31937295
130beta-Alanine metabolism_Homo sapiens_hsa004100.31012630
131Colorectal cancer_Homo sapiens_hsa052100.30351708
132Cholinergic synapse_Homo sapiens_hsa047250.29496523
133Calcium signaling pathway_Homo sapiens_hsa040200.29419131
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29201296
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28964810
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28739299
137Ovarian steroidogenesis_Homo sapiens_hsa049130.28334724
138Pathways in cancer_Homo sapiens_hsa052000.26328351
139Circadian rhythm_Homo sapiens_hsa047100.23094293
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22432895
141ErbB signaling pathway_Homo sapiens_hsa040120.22362218
142Sulfur metabolism_Homo sapiens_hsa009200.22251516
143FoxO signaling pathway_Homo sapiens_hsa040680.21683875

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