SLC25A10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.76587981
2L-phenylalanine catabolic process (GO:0006559)6.76587981
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.69833151
4L-phenylalanine metabolic process (GO:0006558)6.69833151
5proline biosynthetic process (GO:0006561)6.11573905
6aromatic amino acid family catabolic process (GO:0009074)6.04544145
7glyoxylate metabolic process (GO:0046487)5.81601627
8cysteine metabolic process (GO:0006534)5.53979184
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.46467320
10alpha-linolenic acid metabolic process (GO:0036109)5.45373932
11indole-containing compound catabolic process (GO:0042436)5.44298653
12indolalkylamine catabolic process (GO:0046218)5.44298653
13tryptophan catabolic process (GO:0006569)5.44298653
14* sulfur amino acid catabolic process (GO:0000098)5.36880335
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.19752247
16kynurenine metabolic process (GO:0070189)5.19023131
17lysine metabolic process (GO:0006553)5.16218033
18lysine catabolic process (GO:0006554)5.16218033
19tryptophan metabolic process (GO:0006568)5.12722328
20serine family amino acid catabolic process (GO:0009071)5.02788926
21bile acid biosynthetic process (GO:0006699)4.91362144
22urea cycle (GO:0000050)4.75465077
23urea metabolic process (GO:0019627)4.75465077
24homocysteine metabolic process (GO:0050667)4.73792190
25amino-acid betaine metabolic process (GO:0006577)4.64249405
26GDP-mannose metabolic process (GO:0019673)4.46048254
27aromatic amino acid family metabolic process (GO:0009072)4.44997092
28nitrogen cycle metabolic process (GO:0071941)4.42717909
29high-density lipoprotein particle remodeling (GO:0034375)4.42275471
30bile acid metabolic process (GO:0008206)4.40387665
31regulation of triglyceride catabolic process (GO:0010896)4.40036925
32acylglycerol homeostasis (GO:0055090)4.39049783
33triglyceride homeostasis (GO:0070328)4.39049783
34alpha-amino acid catabolic process (GO:1901606)4.34510806
35drug transmembrane transport (GO:0006855)4.34129609
36acetyl-CoA metabolic process (GO:0006084)4.32514666
37complement activation, alternative pathway (GO:0006957)4.29780312
38drug catabolic process (GO:0042737)4.26778531
39serine family amino acid metabolic process (GO:0009069)4.25894151
40urate metabolic process (GO:0046415)4.25061241
41fatty acid beta-oxidation (GO:0006635)4.20649295
42negative regulation of fibrinolysis (GO:0051918)4.18818112
43peptidyl-glutamic acid carboxylation (GO:0017187)4.18611609
44protein carboxylation (GO:0018214)4.18611609
45cellular ketone body metabolic process (GO:0046950)4.17530484
46plasma lipoprotein particle clearance (GO:0034381)4.13348783
47* cellular amino acid catabolic process (GO:0009063)4.11835292
48short-chain fatty acid metabolic process (GO:0046459)4.10110037
49valine metabolic process (GO:0006573)4.10107606
50tyrosine metabolic process (GO:0006570)4.09823627
51regulation of translational fidelity (GO:0006450)4.04926933
52fatty acid oxidation (GO:0019395)4.04813053
53negative regulation of cholesterol transport (GO:0032375)4.02916845
54negative regulation of sterol transport (GO:0032372)4.02916845
55regulation of cholesterol esterification (GO:0010872)4.01229151
56cellular modified amino acid catabolic process (GO:0042219)4.00518317
57serine family amino acid biosynthetic process (GO:0009070)3.98365471
58regulation of protein activation cascade (GO:2000257)3.97848907
59glycine metabolic process (GO:0006544)3.97702173
60lipid oxidation (GO:0034440)3.96433895
61ethanol oxidation (GO:0006069)3.96177941
62reverse cholesterol transport (GO:0043691)3.93507519
63folic acid metabolic process (GO:0046655)3.93394057
64L-serine metabolic process (GO:0006563)3.92410715
65regulation of cholesterol homeostasis (GO:2000188)3.90973072
66regulation of fibrinolysis (GO:0051917)3.90903621
67fatty acid catabolic process (GO:0009062)3.87696405
68protein-lipid complex remodeling (GO:0034368)3.85926698
69macromolecular complex remodeling (GO:0034367)3.85926698
70plasma lipoprotein particle remodeling (GO:0034369)3.85926698
71proline metabolic process (GO:0006560)3.85832469
72COPI coating of Golgi vesicle (GO:0048205)3.85741132
73Golgi transport vesicle coating (GO:0048200)3.85741132
74* organic acid catabolic process (GO:0016054)3.80351395
75* carboxylic acid catabolic process (GO:0046395)3.80351395
76cellular glucuronidation (GO:0052695)3.78085354
77glutamine family amino acid biosynthetic process (GO:0009084)3.77978172
78indolalkylamine metabolic process (GO:0006586)3.77712195
79benzene-containing compound metabolic process (GO:0042537)3.76834361
80monocarboxylic acid catabolic process (GO:0072329)3.76432517
81glutamate metabolic process (GO:0006536)3.74589462
82regulation of mammary gland epithelial cell proliferation (GO:0033599)3.74479778
83regulation of complement activation (GO:0030449)3.74213558
84phospholipid efflux (GO:0033700)3.74111305
85exogenous drug catabolic process (GO:0042738)3.73890450
86drug transport (GO:0015893)3.73155432
87amine catabolic process (GO:0009310)3.70500836
88cellular biogenic amine catabolic process (GO:0042402)3.70500836
892-oxoglutarate metabolic process (GO:0006103)3.70419788
90biotin metabolic process (GO:0006768)3.68710182
91aspartate family amino acid catabolic process (GO:0009068)3.67372700
92carnitine metabolic process (GO:0009437)3.65990999
93branched-chain amino acid metabolic process (GO:0009081)3.64751998
94coenzyme catabolic process (GO:0009109)3.63320012
95NADH metabolic process (GO:0006734)3.60420965
96cholesterol efflux (GO:0033344)3.59410577
97ketone body metabolic process (GO:1902224)3.59302556
98branched-chain amino acid catabolic process (GO:0009083)3.59206126
99DNA unwinding involved in DNA replication (GO:0006268)3.58737844
100plasma lipoprotein particle assembly (GO:0034377)3.57936052
101cholesterol homeostasis (GO:0042632)3.56093404
102sterol homeostasis (GO:0055092)3.52857081
103bile acid and bile salt transport (GO:0015721)3.52656391
104very-low-density lipoprotein particle assembly (GO:0034379)3.52450990
105flavonoid metabolic process (GO:0009812)3.52359053
106positive regulation of lipid catabolic process (GO:0050996)3.51834215
107drug metabolic process (GO:0017144)3.50874211
108heme transport (GO:0015886)3.50457783
109regulation of cholesterol biosynthetic process (GO:0045540)3.50307043
110positive regulation of triglyceride lipase activity (GO:0061365)3.48971996
111positive regulation of lipoprotein lipase activity (GO:0051006)3.48971996
112aldehyde catabolic process (GO:0046185)3.45577673
113protein retention in ER lumen (GO:0006621)3.40769597
114peptidyl-arginine omega-N-methylation (GO:0035247)3.30876859
115mitotic chromosome condensation (GO:0007076)3.21532313
116maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.19751362
117negative regulation of cell size (GO:0045792)3.18250534
118desmosome organization (GO:0002934)3.11822175
119DNA strand elongation involved in DNA replication (GO:0006271)3.01676300
120ribosomal small subunit biogenesis (GO:0042274)3.00521602
121DNA replication initiation (GO:0006270)2.98461579
122pentose metabolic process (GO:0019321)2.96966035
123DNA strand elongation (GO:0022616)2.95702611
124regulation of cholesterol metabolic process (GO:0090181)2.95370238
125folic acid-containing compound metabolic process (GO:0006760)2.94296268
126rRNA transcription (GO:0009303)2.94176224
127pentose-phosphate shunt (GO:0006098)2.93332895
128nucleobase-containing small molecule interconversion (GO:0015949)2.93058849
129glucose catabolic process (GO:0006007)2.91660689
130regulation of plasminogen activation (GO:0010755)2.90161294
131maternal placenta development (GO:0001893)2.85519546
132glucose 6-phosphate metabolic process (GO:0051156)2.85260223
133retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.84729428
134apoptotic process involved in morphogenesis (GO:0060561)2.84154019
135protein maturation by protein folding (GO:0022417)2.80672715
136oxaloacetate metabolic process (GO:0006107)2.77633192
137regulation of glucose import in response to insulin stimulus (GO:2001273)2.74272157
138negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73560972
139* monosaccharide biosynthetic process (GO:0046364)2.69460020
1404-hydroxyproline metabolic process (GO:0019471)2.68878804
141NADPH regeneration (GO:0006740)2.62482227
142purine ribonucleotide transport (GO:0015868)2.61676602
143telomere maintenance via semi-conservative replication (GO:0032201)2.59975107
144protein complex localization (GO:0031503)2.59955878
145histone arginine methylation (GO:0034969)2.58353295
146deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.57407340
147alpha-amino acid biosynthetic process (GO:1901607)2.57126525
148pteridine-containing compound metabolic process (GO:0042558)2.56639295
149tetrahydrofolate metabolic process (GO:0046653)2.55445340
150purine nucleotide transport (GO:0015865)2.54742028
151spliceosomal tri-snRNP complex assembly (GO:0000244)2.53655607
152* hexose biosynthetic process (GO:0019319)2.53440546
153folic acid-containing compound biosynthetic process (GO:0009396)2.52830877
154formation of translation preinitiation complex (GO:0001731)2.51954837
155peptidyl-arginine methylation (GO:0018216)2.50861040
156peptidyl-arginine N-methylation (GO:0035246)2.50861040
157regulation of fatty acid beta-oxidation (GO:0031998)2.50046215
158* gluconeogenesis (GO:0006094)2.48341103
159nuclear envelope reassembly (GO:0031468)2.46995726
160mitotic nuclear envelope reassembly (GO:0007084)2.46995726
161activation of Rac GTPase activity (GO:0032863)2.42540483
162nucleotide-sugar biosynthetic process (GO:0009226)2.41653655
163viral mRNA export from host cell nucleus (GO:0046784)2.40671898
164response to food (GO:0032094)2.38747533
165mitotic sister chromatid segregation (GO:0000070)2.37229656
166DNA strand renaturation (GO:0000733)2.37217934
167DNA replication checkpoint (GO:0000076)2.35904928
168UV protection (GO:0009650)2.34394095
169mitochondrial fusion (GO:0008053)2.33898821
170epoxygenase P450 pathway (GO:0019373)2.33161750
171pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.32213037
172cellular modified amino acid biosynthetic process (GO:0042398)2.32111173
173regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.31811423
174adenine nucleotide transport (GO:0051503)2.31337360
175mitotic G1 DNA damage checkpoint (GO:0031571)2.31088859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.78651357
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.39626717
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.74545702
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.43979146
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.67118301
6EGR1_23403033_ChIP-Seq_LIVER_Mouse5.14236952
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.51988558
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.23264355
9E2F7_22180533_ChIP-Seq_HELA_Human3.71527154
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.50457802
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.48486555
12* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.97042540
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78107625
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44033974
15* VDR_21846776_ChIP-Seq_THP-1_Human2.42751328
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.38457909
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.31436026
18CLOCK_20551151_ChIP-Seq_293T_Human2.15827679
19* XRN2_22483619_ChIP-Seq_HELA_Human2.10309637
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.08443866
21MYC_22102868_ChIP-Seq_BL_Human2.07522866
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04423244
23* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.03796322
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97333626
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89874602
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80995703
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77190183
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70957340
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65342932
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64457308
31* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59314073
32* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55075970
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54940748
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52719580
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52228837
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49739763
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46714487
38* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46015170
39DCP1A_22483619_ChIP-Seq_HELA_Human1.44612816
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.43167613
41* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41447788
42* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40722488
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39742739
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39273456
45ZNF263_19887448_ChIP-Seq_K562_Human1.36636357
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.35658636
47HNF4A_19822575_ChIP-Seq_HepG2_Human1.33805090
48LXR_22292898_ChIP-Seq_THP-1_Human1.33372732
49* GABP_19822575_ChIP-Seq_HepG2_Human1.32508210
50* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.32289119
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31826475
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31590438
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29563060
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.28541553
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26633418
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.26317993
57* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25626453
58SMC4_20622854_ChIP-Seq_HELA_Human1.25310705
59* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25029989
60CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24819218
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24046633
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23932764
63KDM5A_27292631_Chip-Seq_BREAST_Human1.22585394
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21548722
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20837919
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.19819416
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.19786862
68* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18050009
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.17845162
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.17663641
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17047308
72FOXP1_21924763_ChIP-Seq_HESCs_Human1.16860845
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15787963
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13018419
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12696743
76GATA4_25053715_ChIP-Seq_YYC3_Human1.12563558
77TCF7_22412390_ChIP-Seq_EML_Mouse1.11845033
78KDM2B_26808549_Chip-Seq_DND41_Human1.10979426
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10450926
80* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08699194
81* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07593401
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.07056223
83TTF2_22483619_ChIP-Seq_HELA_Human1.06067014
84* RACK7_27058665_Chip-Seq_MCF-7_Human1.05891606
85PHF8_20622854_ChIP-Seq_HELA_Human1.05632559
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05572768
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.05562844
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04472761
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03909033
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03203791
91E2F1_20622854_ChIP-Seq_HELA_Human1.03119655
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02740525
93CTCF_21964334_Chip-Seq_Bcells_Human1.01004105
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99326301
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98003210
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95044738
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93531493
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93453255
99* RARA_24833708_ChIP-Seq_LIVER_Mouse0.91249833
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90724981
101RARB_24833708_ChIP-Seq_LIVER_Mouse0.89239911
102ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87614365
103GATA6_25053715_ChIP-Seq_YYC3_Human0.87457402
104TET1_21451524_ChIP-Seq_MESCs_Mouse0.86138722
105IRF8_22096565_ChIP-ChIP_GC-B_Human0.85607113
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84817991
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83733480
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83664297
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81132974
110GATA1_22025678_ChIP-Seq_K562_Human0.80266566
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80089335
112BCOR_27268052_Chip-Seq_Bcells_Human0.76326191
113TRIM28_21343339_ChIP-Seq_HEK293_Human0.75708652
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.75481469
115SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74443636
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74304079
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.73728759
118ERG_21242973_ChIP-ChIP_JURKAT_Human0.73574625
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73134664
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.72689423
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70263128
122Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66124131
123AR_21909140_ChIP-Seq_LNCAP_Human0.65881175
124HTT_18923047_ChIP-ChIP_STHdh_Human0.65467765
125TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65000450
126BCL6_27268052_Chip-Seq_Bcells_Human0.64854246
127* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64710008
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.64512485
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64260530
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.64132022
131PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63459563
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.62943678
133* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62933912
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.61863971
135SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.61693794
136* ATF3_27146783_Chip-Seq_COLON_Human0.61219604
137P68_20966046_ChIP-Seq_HELA_Human0.61022554
138* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60940119
139P300_27268052_Chip-Seq_Bcells_Human0.60793112
140CEBPB_22108803_ChIP-Seq_LS180_Human0.60675537
141P63_26484246_Chip-Seq_KERATINOCYTES_Human0.60585779
142SOX2_18692474_ChIP-Seq_MEFs_Mouse0.59616881
143BRD4_27068464_Chip-Seq_AML-cells_Mouse0.58296290
144EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.58177684
145CTCF_21964334_ChIP-Seq_BJAB-B_Human0.57969834
146GATA1_19941826_ChIP-Seq_K562_Human0.57463945
147CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.57410217
148GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.57229634
149ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.56851219
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.56428355
151TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.56366389
152CSB_26484114_Chip-Seq_FIBROBLAST_Human0.56102933
153* ELK3_25401928_ChIP-Seq_HUVEC_Human0.55905722
154* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55624721
155* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.55558695
156TCF3_18692474_ChIP-Seq_MEFs_Mouse0.55047891
157NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.54700864
158CREB1_26743006_Chip-Seq_LNCaP_Human0.54549403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.38798225
2MP0005360_urolithiasis7.35816650
3MP0005365_abnormal_bile_salt5.58124873
4MP0005085_abnormal_gallbladder_physiolo5.51268242
5MP0008875_abnormal_xenobiotic_pharmacok4.45771655
6MP0003806_abnormal_nucleotide_metabolis3.62644345
7MP0010329_abnormal_lipoprotein_level3.37236506
8MP0003252_abnormal_bile_duct3.35182955
9MP0009840_abnormal_foam_cell3.21846962
10MP0005332_abnormal_amino_acid3.17459027
11MP0004019_abnormal_vitamin_homeostasis2.84981773
12MP0003693_abnormal_embryo_hatching2.63261823
13MP0003191_abnormal_cellular_cholesterol2.61228623
14MP0003111_abnormal_nucleus_morphology2.57128584
15MP0001666_abnormal_nutrient_absorption2.54292633
16MP0003195_calcinosis2.52491372
17MP0005083_abnormal_biliary_tract2.46143669
18MP0005076_abnormal_cell_differentiation2.38234681
19MP0002118_abnormal_lipid_homeostasis2.17700915
20MP0002249_abnormal_larynx_morphology2.15105850
21MP0000678_abnormal_parathyroid_gland2.13971862
22MP0002138_abnormal_hepatobiliary_system2.12537390
23MP0000609_abnormal_liver_physiology2.12479634
24MP0004957_abnormal_blastocyst_morpholog2.01970444
25MP0005670_abnormal_white_adipose2.01326429
26MP0000537_abnormal_urethra_morphology1.96664138
27MP0010094_abnormal_chromosome_stability1.95633793
28MP0002877_abnormal_melanocyte_morpholog1.95215709
29MP0000003_abnormal_adipose_tissue1.88216097
30MP0005319_abnormal_enzyme/_coenzyme1.87087595
31MP0009643_abnormal_urine_homeostasis1.85826457
32MP0004858_abnormal_nervous_system1.85130247
33MP0003077_abnormal_cell_cycle1.83761171
34MP0003186_abnormal_redox_activity1.79215720
35MP0001764_abnormal_homeostasis1.72530970
36MP0000566_synostosis1.65381026
37MP0005584_abnormal_enzyme/coenzyme_acti1.58318540
38MP0003705_abnormal_hypodermis_morpholog1.56089695
39MP0010030_abnormal_orbit_morphology1.54061178
40MP0005409_darkened_coat_color1.52490808
41MP0004233_abnormal_muscle_weight1.52190025
42MP0003123_paternal_imprinting1.50335322
43MP0008932_abnormal_embryonic_tissue1.49110864
44MP0001346_abnormal_lacrimal_gland1.46649561
45MP0001849_ear_inflammation1.44792151
46MP0005451_abnormal_body_composition1.38371175
47MP0001730_embryonic_growth_arrest1.35332070
48MP0003315_abnormal_perineum_morphology1.34644229
49MP0005666_abnormal_adipose_tissue1.34044096
50MP0005058_abnormal_lysosome_morphology1.30691816
51MP0004130_abnormal_muscle_cell1.24960925
52MP0003656_abnormal_erythrocyte_physiolo1.22053073
53MP0005636_abnormal_mineral_homeostasis1.21543556
54MP0000598_abnormal_liver_morphology1.18682377
55MP0001756_abnormal_urination1.16095017
56MP0002098_abnormal_vibrissa_morphology1.12866824
57MP0002089_abnormal_postnatal_growth/wei1.12417131
58MP0002971_abnormal_brown_adipose1.11437956
59MP0003868_abnormal_feces_composition1.10882719
60MP0000350_abnormal_cell_proliferation1.09505406
61MP0002080_prenatal_lethality1.07831464
62MP0005647_abnormal_sex_gland1.01821937
63MP0000467_abnormal_esophagus_morphology1.00941120
64MP0004043_abnormal_pH_regulation0.99514461
65MP0005330_cardiomyopathy0.99482874
66MP0002876_abnormal_thyroid_physiology0.99366109
67MP0002136_abnormal_kidney_physiology0.98928971
68MP0006036_abnormal_mitochondrial_physio0.98224508
69MP0002160_abnormal_reproductive_system0.97925585
70MP0000858_altered_metastatic_potential0.96812406
71MP0001216_abnormal_epidermal_layer0.95350041
72MP0008007_abnormal_cellular_replicative0.94986737
73MP0002254_reproductive_system_inflammat0.94357158
74MP0005334_abnormal_fat_pad0.93661626
75MP0001672_abnormal_embryogenesis/_devel0.93181190
76MP0005380_embryogenesis_phenotype0.93181190
77MP0009764_decreased_sensitivity_to0.90960121
78MP0004185_abnormal_adipocyte_glucose0.90345097
79MP0005623_abnormal_meninges_morphology0.90033851
80MP0000490_abnormal_crypts_of0.89443411
81MP0003984_embryonic_growth_retardation0.88306396
82MP0009115_abnormal_fat_cell0.88070878
83MP0002796_impaired_skin_barrier0.87789056
84MP0005171_absent_coat_pigmentation0.87342348
85MP0004264_abnormal_extraembryonic_tissu0.86986364
86MP0001697_abnormal_embryo_size0.86944776
87MP0003011_delayed_dark_adaptation0.86881559
88MP0003566_abnormal_cell_adhesion0.86478248
89MP0009642_abnormal_blood_homeostasis0.85470387
90MP0009931_abnormal_skin_appearance0.84373225
91MP0001873_stomach_inflammation0.83917829
92MP0008469_abnormal_protein_level0.83749621
93MP0008260_abnormal_autophagy0.82820423
94MP0002086_abnormal_extraembryonic_tissu0.82689214
95MP0001661_extended_life_span0.82429346
96MP0002088_abnormal_embryonic_growth/wei0.82417156
97MP0001348_abnormal_lacrimal_gland0.81940641
98MP0009763_increased_sensitivity_to0.81636865
99MP0009333_abnormal_splenocyte_physiolog0.81373002
100MP0000604_amyloidosis0.81301722
101MP0005376_homeostasis/metabolism_phenot0.80473195
102MP0003942_abnormal_urinary_system0.78997655
103MP0002078_abnormal_glucose_homeostasis0.78048512
104MP0010771_integument_phenotype0.77765732
105MP0000733_abnormal_muscle_development0.76183921
106MP0000313_abnormal_cell_death0.75975918
107MP0000747_muscle_weakness0.75476388
108MP0005375_adipose_tissue_phenotype0.73165040
109MP0000681_abnormal_thyroid_gland0.72210939
110MP0000477_abnormal_intestine_morphology0.72004628
111MP0000013_abnormal_adipose_tissue0.71405465
112MP0005535_abnormal_body_temperature0.71002250
113MP0002085_abnormal_embryonic_tissue0.70692256
114MP0005266_abnormal_metabolism0.70296400
115MP0000377_abnormal_hair_follicle0.70225582
116MP0003786_premature_aging0.69077955
117MP0000627_abnormal_mammary_gland0.68406003
118MP0003690_abnormal_glial_cell0.66524965
119MP0002970_abnormal_white_adipose0.66524046
120MP0005220_abnormal_exocrine_pancreas0.64537978
121MP0005084_abnormal_gallbladder_morpholo0.64013265
122MP0005448_abnormal_energy_balance0.62018697
123MP0001765_abnormal_ion_homeostasis0.61932031
124MP0005395_other_phenotype0.61650464
125MP0004782_abnormal_surfactant_physiolog0.61425356
126MP0009697_abnormal_copulation0.59536312
127MP0009765_abnormal_xenobiotic_induced0.57904494
128MP0003453_abnormal_keratinocyte_physiol0.57559477
129MP0002168_other_aberrant_phenotype0.57295585
130MP0005408_hypopigmentation0.57209345
131MP0001881_abnormal_mammary_gland0.56115709
132MP0009053_abnormal_anal_canal0.55517108
133MP0002060_abnormal_skin_morphology0.55435813
134MP0003638_abnormal_response/metabolism_0.53429911
135MP0008438_abnormal_cutaneous_collagen0.52742637
136MP0003724_increased_susceptibility_to0.50783577
137MP0000639_abnormal_adrenal_gland0.48833601
138MP0003959_abnormal_lean_body0.47690720
139MP0003718_maternal_effect0.46469413
140MP0003953_abnormal_hormone_level0.45970329
141MP0003075_altered_response_to0.45944120
142MP0010234_abnormal_vibrissa_follicle0.45460221
143MP0002135_abnormal_kidney_morphology0.45337833
144MP0005464_abnormal_platelet_physiology0.44172236
145MP0003300_gastrointestinal_ulcer0.43096331
146MP0005501_abnormal_skin_physiology0.42724789
147MP0006082_CNS_inflammation0.40634875
148MP0000538_abnormal_urinary_bladder0.40333559
149MP0004147_increased_porphyrin_level0.39724533
150MP0003329_amyloid_beta_deposits0.37435752
151MP0008873_increased_physiological_sensi0.37179604
152MP0002928_abnormal_bile_duct0.36947537
153MP0006035_abnormal_mitochondrial_morpho0.34460866
154MP0000230_abnormal_systemic_arterial0.34298162
155MP0009672_abnormal_birth_weight0.33611783
156MP0001845_abnormal_inflammatory_respons0.33504241
157MP0003436_decreased_susceptibility_to0.32889832
158MP0000579_abnormal_nail_morphology0.32048633
159MP0000249_abnormal_blood_vessel0.31222581

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.30397019
2Intrahepatic cholestasis (HP:0001406)5.76968240
3Xanthomatosis (HP:0000991)5.64296651
4Deep venous thrombosis (HP:0002625)5.49685733
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.44902189
6Hyperglycinuria (HP:0003108)5.15331288
7Hypobetalipoproteinemia (HP:0003563)5.04211572
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.87967540
9Abnormality of glycine metabolism (HP:0010895)4.70999263
10Abnormality of serine family amino acid metabolism (HP:0010894)4.70999263
11Hyperammonemia (HP:0001987)4.68749111
12Ketosis (HP:0001946)4.54392976
13Hyperlipoproteinemia (HP:0010980)4.54391216
14Hyperglycinemia (HP:0002154)4.40587934
15Prolonged partial thromboplastin time (HP:0003645)4.37920035
16Complement deficiency (HP:0004431)4.20818833
17Abnormality of aspartate family amino acid metabolism (HP:0010899)3.99331194
18Hypolipoproteinemia (HP:0010981)3.98018963
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.94762860
20Abnormality of fatty-acid metabolism (HP:0004359)3.88468265
21Gout (HP:0001997)3.80831806
22Epidermoid cyst (HP:0200040)3.79479993
23Ketoacidosis (HP:0001993)3.75676135
24Ulnar bowing (HP:0003031)3.74772624
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.70219793
26Testicular atrophy (HP:0000029)3.66681567
27Hypoglycemic coma (HP:0001325)3.64302289
28Hypoalphalipoproteinemia (HP:0003233)3.61652279
29Abnormality of purine metabolism (HP:0004352)3.57559140
30Joint hemorrhage (HP:0005261)3.46981896
31Abnormality of nucleobase metabolism (HP:0010932)3.45901667
32Fat malabsorption (HP:0002630)3.41769889
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38400899
34Abnormality of methionine metabolism (HP:0010901)3.34489874
35Abnormality of pyrimidine metabolism (HP:0004353)3.22586720
36Abnormality of the common coagulation pathway (HP:0010990)3.15018537
37Hypercholesterolemia (HP:0003124)3.13563069
38Abnormality of complement system (HP:0005339)3.12357767
39Dicarboxylic aciduria (HP:0003215)3.04950157
40Abnormality of dicarboxylic acid metabolism (HP:0010995)3.04950157
41Myocardial infarction (HP:0001658)3.02440371
42Proximal tubulopathy (HP:0000114)2.99576494
43Hydroxyprolinuria (HP:0003080)2.99225455
44Abnormality of proline metabolism (HP:0010907)2.99225455
45Delayed CNS myelination (HP:0002188)2.97001133
46Abnormality of serum amino acid levels (HP:0003112)2.93304494
47Metabolic acidosis (HP:0001942)2.86503775
48Generalized aminoaciduria (HP:0002909)2.84907951
49Increased purine levels (HP:0004368)2.84895418
50Hyperuricemia (HP:0002149)2.84895418
51Abnormality of the Achilles tendon (HP:0005109)2.83118697
52Lethargy (HP:0001254)2.81710400
53Thin bony cortex (HP:0002753)2.78408029
54Malnutrition (HP:0004395)2.76670901
55Hyperbilirubinemia (HP:0002904)2.73398349
56Vascular calcification (HP:0004934)2.72585538
57Abnormality of the intrinsic pathway (HP:0010989)2.70698981
58Vaginal fistula (HP:0004320)2.69240633
59Alkalosis (HP:0001948)2.66915384
60Conjugated hyperbilirubinemia (HP:0002908)2.66646658
61Achilles tendon contracture (HP:0001771)2.65894836
62Hepatocellular carcinoma (HP:0001402)2.62700165
63Steatorrhea (HP:0002570)2.58116736
64Septate vagina (HP:0001153)2.53672543
65Hyperacusis (HP:0010780)2.50972166
66Spastic diplegia (HP:0001264)2.47419478
67Systemic lupus erythematosus (HP:0002725)2.47209779
68Vomiting (HP:0002013)2.44493619
69Cardiovascular calcification (HP:0011915)2.43890741
70Broad distal phalanx of finger (HP:0009836)2.41097773
71Irritability (HP:0000737)2.40883736
72Progressive muscle weakness (HP:0003323)2.39321380
73Abnormality of the distal phalanges of the toes (HP:0010182)2.37118402
74Aplasia/Hypoplasia of the sacrum (HP:0008517)2.36001447
75Pancreatitis (HP:0001733)2.35944996
76Hypochromic microcytic anemia (HP:0004840)2.35388039
77Ragged-red muscle fibers (HP:0003200)2.32262745
78Abnormal enzyme/coenzyme activity (HP:0012379)2.31408838
79Nausea (HP:0002018)2.29758400
80Abnormality of urine glucose concentration (HP:0011016)2.29199558
81Glycosuria (HP:0003076)2.29199558
82Asymmetry of the thorax (HP:0001555)2.27617576
83Breast hypoplasia (HP:0003187)2.26975098
84Late onset (HP:0003584)2.26832786
85Abnormality of glycolysis (HP:0004366)2.26541533
86Opisthotonus (HP:0002179)2.26463326
87Abnormality of the umbilical cord (HP:0010881)2.26406368
88Stridor (HP:0010307)2.26050950
89Skin nodule (HP:0200036)2.23301805
90Flat acetabular roof (HP:0003180)2.20451063
91Hypertriglyceridemia (HP:0002155)2.20388412
92Rickets (HP:0002748)2.19921973
93Poikiloderma (HP:0001029)2.18445696
94Neonatal onset (HP:0003623)2.17219434
95Cerebral edema (HP:0002181)2.15907694
96Abnormal cartilage morphology (HP:0002763)2.14915338
97Abnormality of the gallbladder (HP:0005264)2.14574458
98Reticulocytosis (HP:0001923)2.14173657
99Squamous cell carcinoma (HP:0002860)2.13048983
100Myopathic facies (HP:0002058)2.12615229
101Sensorimotor neuropathy (HP:0007141)2.11126494
102Turricephaly (HP:0000262)2.08966619
103Abnormality of alkaline phosphatase activity (HP:0004379)2.08376913
104Brushfield spots (HP:0001088)2.07003989
105Esophageal varix (HP:0002040)2.06341953
106Microvesicular hepatic steatosis (HP:0001414)2.01976238
107Vertebral compression fractures (HP:0002953)2.01257454
108Nephrolithiasis (HP:0000787)2.00826272
109Birth length less than 3rd percentile (HP:0003561)1.98934353
110Hemorrhage of the eye (HP:0011885)1.98320751
111Enlarged kidneys (HP:0000105)1.98130911
112Back pain (HP:0003418)1.96800959
113Hypokinesia (HP:0002375)1.96074600
114Hypoglycemic seizures (HP:0002173)1.95754881
115Abnormal tarsal ossification (HP:0008369)1.92495066
116Intestinal fistula (HP:0100819)1.92108049
117Trismus (HP:0000211)1.92054443
118Unilateral renal agenesis (HP:0000122)1.91516893
119Abnormalities of placenta or umbilical cord (HP:0001194)1.91509595
120Microretrognathia (HP:0000308)1.91122043
121Spontaneous abortion (HP:0005268)1.90592658
122Abnormality of carpal bone ossification (HP:0006257)1.89390555
123Rectal fistula (HP:0100590)1.89246650
124Rectovaginal fistula (HP:0000143)1.89246650
125Hyperactive renin-angiotensin system (HP:0000841)1.88466887
126Self-mutilation (HP:0000742)1.88301241
127Abdominal distention (HP:0003270)1.87989572
128Cholelithiasis (HP:0001081)1.87963563
129Abnormal gallbladder morphology (HP:0012437)1.87788062
130Abnormality of reticulocytes (HP:0004312)1.86249557
131Glomerulonephritis (HP:0000099)1.85365825
132Hypokalemic alkalosis (HP:0001949)1.85302960
133Biconcave vertebral bodies (HP:0004586)1.85151684
134Bowed forearm bones (HP:0003956)1.84441517
135Bowing of the arm (HP:0006488)1.84441517
136Abnormality of transition element cation homeostasis (HP:0011030)1.83709030
137Delayed epiphyseal ossification (HP:0002663)1.83384428
138Cholecystitis (HP:0001082)1.81366513
139Abnormal gallbladder physiology (HP:0012438)1.81366513
140Reduced antithrombin III activity (HP:0001976)1.80630015
141Ileus (HP:0002595)1.79995051
142Premature skin wrinkling (HP:0100678)1.79358011
143Elevated alkaline phosphatase (HP:0003155)1.78317868
144Polycythemia (HP:0001901)1.78292833
145J-shaped sella turcica (HP:0002680)1.76834351
146Abnormality of the fetal cardiovascular system (HP:0010948)1.76435048
147Abnormal umbilical cord blood vessels (HP:0011403)1.76435048
148Single umbilical artery (HP:0001195)1.76435048
149Menorrhagia (HP:0000132)1.75390780
150Nephritis (HP:0000123)1.74822120
151Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74336188
152Acanthocytosis (HP:0001927)1.73819687
153Increased muscle lipid content (HP:0009058)1.73585378
154Broad face (HP:0000283)1.73116615
155Increased serum pyruvate (HP:0003542)1.72685767
156Sparse lateral eyebrow (HP:0005338)1.72465126
157Pterygium (HP:0001059)1.72001177
158Hyperthyroidism (HP:0000836)1.71836020
159Selective tooth agenesis (HP:0001592)1.71139306
160Facial hemangioma (HP:0000329)1.70979306
161Hypoparathyroidism (HP:0000829)1.69391700
162Truncus arteriosus (HP:0001660)1.68434104
163Acanthosis nigricans (HP:0000956)1.65998562
164Abnormal trabecular bone morphology (HP:0100671)1.65858203
165Long palpebral fissure (HP:0000637)1.65769931
166Abnormal ossification of hand bones (HP:0005921)1.65287158
167Short nail (HP:0001799)1.64950839
168Spinal cord compression (HP:0002176)1.64192253
169Hyperparathyroidism (HP:0000843)1.63562712
170Bulbar palsy (HP:0001283)1.62070326
171Chromosomal breakage induced by crosslinking agents (HP:0003221)1.60326184
172Abnormal urine phosphate concentration (HP:0012599)1.60158195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.45019393
2SMG14.22197609
3SIK13.96567228
4ERN13.65146290
5TRIB33.12813409
6FGFR42.84515086
7EEF2K2.82207918
8ICK2.69244264
9VRK22.30045585
10MAPK152.27710917
11WNK42.20414171
12MST1R2.17797054
13BUB12.13333834
14PINK12.01870871
15DDR21.99922609
16MAP3K111.96012453
17MAP3K61.77846913
18CAMK1D1.77568272
19PRKD31.76411526
20MAPK111.76337255
21RPS6KB21.74492307
22CDK121.73457442
23PKN21.68342041
24OXSR11.57470934
25STK38L1.57070651
26TESK21.51118883
27WNK31.50501716
28SCYL21.41767950
29PRPF4B1.41226320
30TESK11.39041531
31DYRK1B1.38046609
32PRKAA21.33616386
33PDK31.33031942
34PDK41.33031942
35IRAK21.32386207
36CDK61.32195091
37MAP3K101.31999104
38CSK1.30182165
39LATS11.30104349
40BMX1.28933759
41INSRR1.28665149
42ERBB41.23256096
43ARAF1.23210654
44GSK3A1.22994436
45EPHB11.21161317
46PTK61.20886215
47TYK21.20002514
48CDK81.16806459
49TAOK31.13417355
50FLT31.13312462
51MATK1.08419635
52AURKA1.06505046
53MAP3K31.06333628
54EIF2AK11.05376102
55NEK91.05286286
56ILK1.04193286
57FRK1.03632393
58MAPKAPK31.03365156
59MUSK1.02326998
60PBK1.00905945
61MET1.00832851
62ABL21.00032721
63PDGFRA0.98497823
64CHEK20.94931648
65RIPK10.93913163
66PRKAA10.93424846
67BRSK10.90132881
68TTK0.89883335
69KDR0.88821937
70CDC70.88629381
71MAP2K30.88626009
72JAK20.85387656
73PRKCI0.84888411
74BRAF0.83626340
75GRK60.83169689
76TBK10.82351275
77IRAK30.82178071
78TAF10.81859734
79CAMK1G0.81825040
80MAP3K80.79554430
81EPHA20.79299251
82PIK3CG0.77813528
83TGFBR20.76988155
84MAP2K20.74882878
85PDK20.71836691
86NEK10.71766890
87STK390.71663871
88PTK20.69073026
89FGR0.68761134
90AKT20.68499649
91MAPK40.67951733
92TTN0.67638425
93MAP3K70.65245464
94MTOR0.65009124
95TLK10.63771238
96AURKB0.63114495
97PRKCZ0.62328278
98ATR0.62248547
99STK160.61154089
100CDK90.60531999
101FGFR20.58354294
102PRKD20.57690395
103PIM10.56535840
104PIM20.56404726
105PRKACG0.54792394
106TAOK10.54768995
107NEK20.52142448
108STK40.52078479
109CDK40.49759169
110CHEK10.49561892
111NME10.48253376
112PDPK10.47646362
113ERBB20.46904337
114LRRK20.45534183
115DAPK10.45500455
116TIE10.44477772
117MAP2K10.44342805
118SRPK10.44149787
119RPS6KA20.44023985
120MAP2K40.43801115
121TYRO30.43635264
122LATS20.43527052
123MAP3K10.43132550
124MAP3K140.43119844
125CAMK2G0.42784655
126JAK10.42761057
127STK30.42307635
128PLK10.42077546
129IRAK40.40417762
130MELK0.39867131
131HIPK20.37650661
132PAK10.36676355
133EGFR0.35131309
134CDK10.34946097
135CDK11A0.34705111
136RPS6KC10.33857018
137RPS6KL10.33857018
138DAPK30.33368024
139CDK20.32380877
140CDK150.32306912
141TAOK20.31374237
142RPS6KA60.31251314
143CSF1R0.30595440
144EPHB20.30128067
145KSR20.29684224
146CCNB10.29235946
147RPS6KA10.28955563
148MAPKAPK50.28477957
149CSNK1G10.28352272
150LMTK20.27651612
151PRKG20.27101007
152PAK40.26858360
153MAP2K60.26577560
154CDK70.25519432
155CHUK0.24783402
156NME20.24637418

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.58146548
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32645879
3Nitrogen metabolism_Homo sapiens_hsa009102.80998078
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.79800653
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.77656670
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73518576
7Fatty acid degradation_Homo sapiens_hsa000712.69103287
8Arginine biosynthesis_Homo sapiens_hsa002202.64491941
9Tryptophan metabolism_Homo sapiens_hsa003802.57393703
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.55331574
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.51272166
12DNA replication_Homo sapiens_hsa030302.50161885
13Propanoate metabolism_Homo sapiens_hsa006402.46651422
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45702109
15Butanoate metabolism_Homo sapiens_hsa006502.32575416
16Fatty acid metabolism_Homo sapiens_hsa012122.29885785
17Peroxisome_Homo sapiens_hsa041462.20557173
18PPAR signaling pathway_Homo sapiens_hsa033202.15033086
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.13956825
20Complement and coagulation cascades_Homo sapiens_hsa046101.96970590
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91638388
22beta-Alanine metabolism_Homo sapiens_hsa004101.88995582
23Base excision repair_Homo sapiens_hsa034101.80557342
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80081618
25Pyruvate metabolism_Homo sapiens_hsa006201.77749956
26Histidine metabolism_Homo sapiens_hsa003401.76159591
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71260318
28Chemical carcinogenesis_Homo sapiens_hsa052041.70330697
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62871420
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.60593039
31Caffeine metabolism_Homo sapiens_hsa002321.58386356
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.56129937
33Sulfur metabolism_Homo sapiens_hsa009201.53025244
34Fatty acid biosynthesis_Homo sapiens_hsa000611.52328501
35Folate biosynthesis_Homo sapiens_hsa007901.45758307
36Phenylalanine metabolism_Homo sapiens_hsa003601.45341033
37Selenocompound metabolism_Homo sapiens_hsa004501.44716129
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42391430
39Carbon metabolism_Homo sapiens_hsa012001.41832555
40Retinol metabolism_Homo sapiens_hsa008301.41607949
41Fatty acid elongation_Homo sapiens_hsa000621.41091202
42Biosynthesis of amino acids_Homo sapiens_hsa012301.37364922
43Bile secretion_Homo sapiens_hsa049761.36624094
44Fat digestion and absorption_Homo sapiens_hsa049751.36555303
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.36297518
46Staphylococcus aureus infection_Homo sapiens_hsa051501.32985141
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32946999
48Starch and sucrose metabolism_Homo sapiens_hsa005001.29049938
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28046580
50Arginine and proline metabolism_Homo sapiens_hsa003301.23357416
51Tyrosine metabolism_Homo sapiens_hsa003501.23160802
52Pyrimidine metabolism_Homo sapiens_hsa002401.22239521
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.21411860
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16955459
55Sulfur relay system_Homo sapiens_hsa041221.13913276
56Vitamin digestion and absorption_Homo sapiens_hsa049771.13063293
57Glycerolipid metabolism_Homo sapiens_hsa005611.09333509
58N-Glycan biosynthesis_Homo sapiens_hsa005101.08703169
59Steroid biosynthesis_Homo sapiens_hsa001001.08272444
60Mismatch repair_Homo sapiens_hsa034301.07600835
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05456444
62Ribosome_Homo sapiens_hsa030101.04141069
63Glutathione metabolism_Homo sapiens_hsa004801.03316627
64ABC transporters_Homo sapiens_hsa020101.02165655
65Lysine degradation_Homo sapiens_hsa003100.96342896
66* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94264417
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87489949
68Cell cycle_Homo sapiens_hsa041100.85487118
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.85440536
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84150302
71Vitamin B6 metabolism_Homo sapiens_hsa007500.80785688
72Thyroid cancer_Homo sapiens_hsa052160.79801136
73Pentose phosphate pathway_Homo sapiens_hsa000300.78613742
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77928893
75Non-small cell lung cancer_Homo sapiens_hsa052230.73279165
76Spliceosome_Homo sapiens_hsa030400.71371599
77Nucleotide excision repair_Homo sapiens_hsa034200.70160654
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69241786
79Chronic myeloid leukemia_Homo sapiens_hsa052200.68658403
80One carbon pool by folate_Homo sapiens_hsa006700.65651334
81Fructose and mannose metabolism_Homo sapiens_hsa000510.62555678
82RNA transport_Homo sapiens_hsa030130.58698298
83Notch signaling pathway_Homo sapiens_hsa043300.57310535
84Sphingolipid metabolism_Homo sapiens_hsa006000.53539134
85Metabolic pathways_Homo sapiens_hsa011000.52818284
86Acute myeloid leukemia_Homo sapiens_hsa052210.48730700
87Galactose metabolism_Homo sapiens_hsa000520.46103800
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45822299
89mTOR signaling pathway_Homo sapiens_hsa041500.45698983
90Pancreatic cancer_Homo sapiens_hsa052120.42807960
91VEGF signaling pathway_Homo sapiens_hsa043700.42578280
92Vibrio cholerae infection_Homo sapiens_hsa051100.42436165
93Homologous recombination_Homo sapiens_hsa034400.40229475
94Endometrial cancer_Homo sapiens_hsa052130.40123468
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40094796
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.36629907
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35476863
98RNA polymerase_Homo sapiens_hsa030200.33726905
99mRNA surveillance pathway_Homo sapiens_hsa030150.33085672
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32620142
101Fanconi anemia pathway_Homo sapiens_hsa034600.31439963
102Insulin resistance_Homo sapiens_hsa049310.26321466
103AMPK signaling pathway_Homo sapiens_hsa041520.25651608
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24113142
105Linoleic acid metabolism_Homo sapiens_hsa005910.22460576
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.21952785
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21555977
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.17623795
109Mineral absorption_Homo sapiens_hsa049780.16259349
110Renin-angiotensin system_Homo sapiens_hsa046140.14822884
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07848073
112Protein digestion and absorption_Homo sapiens_hsa049740.07266724
113Arachidonic acid metabolism_Homo sapiens_hsa005900.06378926
114Lysosome_Homo sapiens_hsa041420.05263993
115Prion diseases_Homo sapiens_hsa050200.04687019
116Glucagon signaling pathway_Homo sapiens_hsa049220.03633292
117Regulation of autophagy_Homo sapiens_hsa04140-0.2129939
118Legionellosis_Homo sapiens_hsa05134-0.2085750
119Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2041147
120Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1623986
121Hepatitis C_Homo sapiens_hsa05160-0.1465346
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1449845
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1376058
124Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1351053
125Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1081690
126Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0549433
127Other glycan degradation_Homo sapiens_hsa00511-0.0536216
128Bladder cancer_Homo sapiens_hsa05219-0.0433756
129Insulin signaling pathway_Homo sapiens_hsa04910-0.0031323

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