SLC25A11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)7.51118180
2sarcomere organization (GO:0045214)6.77789049
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.02482514
4NADH metabolic process (GO:0006734)5.97006057
5cardiac myofibril assembly (GO:0055003)5.93831490
6muscle filament sliding (GO:0030049)5.76729549
7actin-myosin filament sliding (GO:0033275)5.76729549
8ATP synthesis coupled proton transport (GO:0015986)5.53990316
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.53990316
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.51064271
11oxidative phosphorylation (GO:0006119)5.50340184
12regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.44936308
13myofibril assembly (GO:0030239)5.29371901
14negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.21411388
15cardiac muscle contraction (GO:0060048)5.20876115
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.16240285
17regulation of relaxation of muscle (GO:1901077)5.11407950
182-oxoglutarate metabolic process (GO:0006103)5.04926255
19regulation of acyl-CoA biosynthetic process (GO:0050812)5.04872345
20respiratory electron transport chain (GO:0022904)5.01323026
21negative regulation of potassium ion transmembrane transport (GO:1901380)4.94679719
22regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.93241250
23electron transport chain (GO:0022900)4.89370776
24carnitine shuttle (GO:0006853)4.87591543
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.84845273
26oxaloacetate metabolic process (GO:0006107)4.84697001
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.84085116
28regulation of skeletal muscle contraction (GO:0014819)4.83415092
29regulation of cofactor metabolic process (GO:0051193)4.76515622
30regulation of coenzyme metabolic process (GO:0051196)4.76515622
31succinate metabolic process (GO:0006105)4.72666525
32lysine catabolic process (GO:0006554)4.68247259
33lysine metabolic process (GO:0006553)4.68247259
34regulation of mitochondrial translation (GO:0070129)4.62715848
35chaperone-mediated protein transport (GO:0072321)4.61995205
36regulation of actin filament-based movement (GO:1903115)4.61762929
37actin-mediated cell contraction (GO:0070252)4.57100581
38regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.43638080
39fatty acid transmembrane transport (GO:1902001)4.36974547
40heart contraction (GO:0060047)4.36177878
41heart process (GO:0003015)4.36177878
42cardiac muscle cell development (GO:0055013)4.33719073
43aspartate family amino acid catabolic process (GO:0009068)4.32039375
44tricarboxylic acid metabolic process (GO:0072350)4.31697114
45negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.24711720
46regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.23902275
47fatty acid beta-oxidation (GO:0006635)4.21679136
48striated muscle contraction (GO:0006941)4.16025177
49regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.14084547
50cardiac muscle hypertrophy (GO:0003300)4.12096129
51plasma membrane repair (GO:0001778)4.11295765
52ventricular cardiac muscle cell action potential (GO:0086005)4.08163153
53actomyosin structure organization (GO:0031032)4.08124500
54cardiac muscle tissue morphogenesis (GO:0055008)4.05428460
55cardiac cell development (GO:0055006)4.00971575
56regulation of cell communication by electrical coupling (GO:0010649)3.96127408
57bundle of His cell to Purkinje myocyte communication (GO:0086069)3.95794696
58striated muscle hypertrophy (GO:0014897)3.94163633
59sarcoplasmic reticulum calcium ion transport (GO:0070296)3.91965989
60branched-chain amino acid catabolic process (GO:0009083)3.90865623
61protein maturation by protein folding (GO:0022417)3.85970078
62ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.81132900
63regulation of sulfur metabolic process (GO:0042762)3.80499664
64* gluconeogenesis (GO:0006094)3.78375887
65protein targeting to mitochondrion (GO:0006626)3.77882635
66ATP biosynthetic process (GO:0006754)3.74586167
67nucleotide salvage (GO:0043173)3.72203169
68skeletal muscle contraction (GO:0003009)3.68805707
69carnitine transmembrane transport (GO:1902603)3.68763833
70regulation of sarcomere organization (GO:0060297)3.68285450
71peptidyl-arginine omega-N-methylation (GO:0035247)3.67569376
72regulation of striated muscle contraction (GO:0006942)3.66594729
73fatty acid catabolic process (GO:0009062)3.65426044
74cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.65364557
75muscle tissue morphogenesis (GO:0060415)3.62516973
76heart trabecula formation (GO:0060347)3.61921911
77regulation of fatty acid oxidation (GO:0046320)3.61507643
78branched-chain amino acid metabolic process (GO:0009081)3.60451672
79valine metabolic process (GO:0006573)3.57999482
80pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.57642422
81amino-acid betaine transport (GO:0015838)3.57194012
82carnitine transport (GO:0015879)3.57194012
83cellular ketone body metabolic process (GO:0046950)3.56221631
84muscle hypertrophy (GO:0014896)3.55044409
85fatty acid oxidation (GO:0019395)3.53795174
86establishment of protein localization to mitochondrion (GO:0072655)3.51908749
87ubiquinone biosynthetic process (GO:0006744)3.51672392
88quinone biosynthetic process (GO:1901663)3.51672392
89purine nucleotide salvage (GO:0032261)3.50848009
90* monosaccharide biosynthetic process (GO:0046364)3.50366306
91* hexose biosynthetic process (GO:0019319)3.48663226
92mitochondrial fusion (GO:0008053)3.46236368
93lipid oxidation (GO:0034440)3.46159989
94regulation of sequestering of triglyceride (GO:0010889)3.43091988
95regulation of the force of heart contraction (GO:0002026)3.40347255
96mitochondrial respiratory chain complex I assembly (GO:0032981)3.38923877
97NADH dehydrogenase complex assembly (GO:0010257)3.38923877
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38923877
99protein complex biogenesis (GO:0070271)3.38019305
100regulation of membrane repolarization (GO:0060306)3.36898710
101metallo-sulfur cluster assembly (GO:0031163)3.36709474
102iron-sulfur cluster assembly (GO:0016226)3.36709474
103regulation of ATPase activity (GO:0043462)3.36585130
104regulation of ATP catabolic process (GO:1903289)3.36585130
105cell communication involved in cardiac conduction (GO:0086065)3.35939605
106aerobic respiration (GO:0009060)3.33306774
107adult heart development (GO:0007512)3.31611996
108protein localization to mitochondrion (GO:0070585)3.31088649
109establishment of protein localization to mitochondrial membrane (GO:0090151)3.30196395
110glycogen catabolic process (GO:0005980)3.21462732
111creatine metabolic process (GO:0006600)3.20572560
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.19653086
113actin filament-based movement (GO:0030048)3.19106486
114monocarboxylic acid catabolic process (GO:0072329)3.18899847
115pyrimidine ribonucleoside catabolic process (GO:0046133)3.18323826
116acetyl-CoA metabolic process (GO:0006084)3.16935325
117short-chain fatty acid metabolic process (GO:0046459)3.16320048
118mitochondrial respiratory chain complex assembly (GO:0033108)3.16113884
119regulation of cardiac muscle cell contraction (GO:0086004)3.15453515
120mitochondrial transport (GO:0006839)3.14623155
121histone arginine methylation (GO:0034969)3.14186625
122carnitine metabolic process (GO:0009437)3.12936831
123protein deneddylation (GO:0000338)3.12785345
124inner mitochondrial membrane organization (GO:0007007)3.12666576
125regulation of cellular respiration (GO:0043457)3.09407628
126ribosomal small subunit biogenesis (GO:0042274)3.08662452
127deoxyribonucleotide catabolic process (GO:0009264)3.07886810
128galactose catabolic process (GO:0019388)3.07448303
129cardiac muscle adaptation (GO:0014887)3.06524881
130cardiac muscle hypertrophy in response to stress (GO:0014898)3.06524881
131muscle hypertrophy in response to stress (GO:0003299)3.06524881
132ribosomal small subunit assembly (GO:0000028)3.05561699
133cell communication by electrical coupling (GO:0010644)3.04351547
134cullin deneddylation (GO:0010388)3.04316330
135negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02550912
136negative regulation of ligase activity (GO:0051352)3.02550912
137DNA strand elongation involved in DNA replication (GO:0006271)3.00190175
138nucleobase-containing small molecule interconversion (GO:0015949)2.99194648
139deoxyribose phosphate catabolic process (GO:0046386)2.97205389
140purine nucleoside monophosphate biosynthetic process (GO:0009127)2.96847863
141purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.96847863
142GDP-mannose metabolic process (GO:0019673)2.95967502
143establishment of viral latency (GO:0019043)2.95747134
144pyrimidine-containing compound salvage (GO:0008655)2.94196065
145pyrimidine nucleoside salvage (GO:0043097)2.94196065
146establishment of integrated proviral latency (GO:0075713)2.93389946
147purine deoxyribonucleotide catabolic process (GO:0009155)2.92571938
148peptidyl-arginine N-methylation (GO:0035246)2.90908679
149peptidyl-arginine methylation (GO:0018216)2.90908679
150positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.90720517
151pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.90309437
152DNA strand elongation (GO:0022616)2.88559922
153nucleoside salvage (GO:0043174)2.88552653
154positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87852898
155pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.87396307
156glycolytic process (GO:0006096)2.87196217
157mitotic nuclear envelope reassembly (GO:0007084)2.85879300
158nuclear envelope reassembly (GO:0031468)2.85879300
159guanosine-containing compound biosynthetic process (GO:1901070)2.84502465
160regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83979651
161nucleoside monophosphate biosynthetic process (GO:0009124)2.83619606
162anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82838623
163regulation of cellular amino acid metabolic process (GO:0006521)2.82732030
164ribonucleoside triphosphate biosynthetic process (GO:0009201)2.81333693
165proline biosynthetic process (GO:0006561)2.81154222
166ubiquinone metabolic process (GO:0006743)2.80920163
167pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.79856383
168ribonucleoside monophosphate biosynthetic process (GO:0009156)2.79771826
169L-serine metabolic process (GO:0006563)2.79368173
170telomere maintenance via semi-conservative replication (GO:0032201)2.77565076
171pyrimidine nucleotide catabolic process (GO:0006244)2.77315549
172purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.77208802
173skeletal muscle fiber development (GO:0048741)2.75512789
174deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.74694799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.82248082
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.80952369
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.67510821
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.99928594
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16850206
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.05752799
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.99568360
8* MYC_18555785_ChIP-Seq_MESCs_Mouse2.84559929
9ZNF263_19887448_ChIP-Seq_K562_Human2.53150621
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48770928
11TBX20_22328084_ChIP-Seq_HEART_Mouse2.27782473
12TBX20_22080862_ChIP-Seq_HEART_Mouse2.27782473
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21379677
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.21149385
15XRN2_22483619_ChIP-Seq_HELA_Human2.16397936
16* CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.14750022
17E2F7_22180533_ChIP-Seq_HELA_Human2.08330363
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.08175137
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05298700
20EP300_21415370_ChIP-Seq_HL-1_Mouse2.03443672
21* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86962123
22* GABP_19822575_ChIP-Seq_HepG2_Human1.84771055
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83893856
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.80476785
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.79471079
26ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77916421
27CLOCK_20551151_ChIP-Seq_293T_Human1.76731334
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75944334
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75657485
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.75358464
31BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.74347890
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74255710
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.73579725
34DCP1A_22483619_ChIP-Seq_HELA_Human1.71823195
35LXR_22292898_ChIP-Seq_THP-1_Human1.71289337
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69342921
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69217396
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68674633
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.68089077
40GATA4_21415370_ChIP-Seq_HL-1_Mouse1.67855656
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67559350
42MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.63587460
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61663223
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61047018
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.51348922
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51084288
47GATA1_22025678_ChIP-Seq_K562_Human1.49165983
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48579784
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48144493
50* BCL6_27268052_Chip-Seq_Bcells_Human1.47008703
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46561412
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45638939
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45539106
54SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.42903210
55* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38352053
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37793025
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37508889
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37343533
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34438096
60TTF2_22483619_ChIP-Seq_HELA_Human1.32559690
61FOXP3_21729870_ChIP-Seq_TREG_Human1.28332342
62CIITA_25753668_ChIP-Seq_RAJI_Human1.26289923
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25477034
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25437190
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25341221
66* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25320778
67FOXP1_21924763_ChIP-Seq_HESCs_Human1.24729332
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24432267
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24142465
70NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23915979
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23158121
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22644017
73* P68_20966046_ChIP-Seq_HELA_Human1.22263103
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22075573
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.20254692
76OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20075195
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.19713882
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18962452
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18310175
80* BCOR_27268052_Chip-Seq_Bcells_Human1.18207609
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17487710
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17441646
83MYC_22102868_ChIP-Seq_BL_Human1.17281985
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.15639087
85* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14810616
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14011829
87TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12854166
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12844565
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.12633785
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.12256291
91ETS1_20019798_ChIP-Seq_JURKAT_Human1.12228289
92KDM5A_27292631_Chip-Seq_BREAST_Human1.11721236
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10981120
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.10253126
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10141324
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10141200
97VDR_23849224_ChIP-Seq_CD4+_Human1.09532259
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08296598
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08073494
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08037614
101PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07770386
102CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07255235
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06792381
104TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06777543
105RACK7_27058665_Chip-Seq_MCF-7_Human1.06342912
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06304182
107ELF1_20517297_ChIP-Seq_JURKAT_Human1.05362564
108THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05341926
109* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04184559
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03861732
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03181106
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02592136
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01930087
114ATF3_27146783_Chip-Seq_COLON_Human1.01781062
115HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01270054
116CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00981463
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00678217
118SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00303026
119CTCF_21964334_Chip-Seq_Bcells_Human0.99373698
120VDR_21846776_ChIP-Seq_THP-1_Human0.99370188
121RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98012053
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97330084
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96788573
124SPI1_20517297_ChIP-Seq_HL60_Human0.96775283
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96317426
126* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94547948
127* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92170682
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91504240
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90897217
130* HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90578900
131CTCF_26484167_Chip-Seq_Bcells_Mouse0.90433792
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89009612
133TP63_22573176_ChIP-Seq_HFKS_Human0.88837860
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87768370
135* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86904240
136* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86401229
137YY1_21170310_ChIP-Seq_MESCs_Mouse0.85713785
138OCT4_20526341_ChIP-Seq_ESCs_Human0.84534170
139ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84305703
140SA1_27219007_Chip-Seq_ERYTHROID_Human0.84056426
141* SA1_27219007_Chip-Seq_Bcells_Human0.84048350
142EGR1_19032775_ChIP-ChIP_M12_Human0.83821576
143CTCF_27219007_Chip-Seq_Bcells_Human0.83495144
144GABP_17652178_ChIP-ChIP_JURKAT_Human0.83375573
145BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82018201
146E2F1_20622854_ChIP-Seq_HELA_Human0.81883164
147* PHF8_20622854_ChIP-Seq_HELA_Human0.81280663
148MAF_26560356_Chip-Seq_TH1_Human0.81040218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.60081579
2MP0003646_muscle_fatigue5.42770596
3MP0004084_abnormal_cardiac_muscle4.85264725
4MP0000751_myopathy4.72471931
5MP0004215_abnormal_myocardial_fiber4.16840409
6MP0004036_abnormal_muscle_relaxation3.93133041
7MP0000749_muscle_degeneration3.78070817
8MP0005330_cardiomyopathy3.58684731
9MP0004130_abnormal_muscle_cell2.83066829
10MP0006036_abnormal_mitochondrial_physio2.81217942
11MP0002972_abnormal_cardiac_muscle2.73662454
12MP0004087_abnormal_muscle_fiber2.72793575
13MP0005620_abnormal_muscle_contractility2.45602578
14MP0000750_abnormal_muscle_regeneration2.42896836
15MP0008775_abnormal_heart_ventricle2.41157171
16MP0003137_abnormal_impulse_conducting2.40222164
17MP0002269_muscular_atrophy2.34266170
18MP0001544_abnormal_cardiovascular_syste2.32475932
19MP0005385_cardiovascular_system_phenoty2.32475932
20MP0002106_abnormal_muscle_physiology2.31481411
21MP0003693_abnormal_embryo_hatching2.25860641
22MP0004233_abnormal_muscle_weight2.16612113
23MP0004484_altered_response_of2.12571503
24MP0000747_muscle_weakness2.11953830
25MP0010630_abnormal_cardiac_muscle2.11831928
26MP0008260_abnormal_autophagy2.07201509
27MP0004145_abnormal_muscle_electrophysio2.03759591
28MP0003221_abnormal_cardiomyocyte_apopto2.02954711
29MP0003806_abnormal_nucleotide_metabolis2.00020955
30MP0004858_abnormal_nervous_system1.95045962
31MP0006138_congestive_heart_failure1.94639570
32MP0000759_abnormal_skeletal_muscle1.84686807
33MP0005369_muscle_phenotype1.82248281
34MP0006035_abnormal_mitochondrial_morpho1.75847071
35MP0004085_abnormal_heartbeat1.72171333
36MP0003111_abnormal_nucleus_morphology1.68300375
37MP0003828_pulmonary_edema1.67108709
38MP0004510_myositis1.64201728
39MP0005360_urolithiasis1.58636992
40MP0002332_abnormal_exercise_endurance1.52785368
41MP0009840_abnormal_foam_cell1.52709313
42MP0010094_abnormal_chromosome_stability1.46840103
43MP0008932_abnormal_embryonic_tissue1.46480944
44MP0005085_abnormal_gallbladder_physiolo1.44370517
45MP0008058_abnormal_DNA_repair1.43334028
46MP0002139_abnormal_hepatobiliary_system1.42649662
47MP0000343_altered_response_to1.35837706
48MP0000733_abnormal_muscle_development1.35164622
49MP0005332_abnormal_amino_acid1.34853927
50MP0010030_abnormal_orbit_morphology1.33109543
51MP0000372_irregular_coat_pigmentation1.30270870
52MP0002653_abnormal_ependyma_morphology1.28579453
53MP0004270_analgesia1.25439597
54MP0002127_abnormal_cardiovascular_syste1.22589127
55MP0003195_calcinosis1.22479350
56MP0005666_abnormal_adipose_tissue1.22467357
57MP0005083_abnormal_biliary_tract1.22139456
58MP0005365_abnormal_bile_salt1.21209747
59MP0005670_abnormal_white_adipose1.18927659
60MP0002909_abnormal_adrenal_gland1.18586586
61MP0005319_abnormal_enzyme/_coenzyme1.17619693
62MP0004043_abnormal_pH_regulation1.14249706
63MP0004957_abnormal_blastocyst_morpholog1.13961037
64MP0008007_abnormal_cellular_replicative1.12659504
65MP0005266_abnormal_metabolism1.11806229
66MP0005165_increased_susceptibility_to1.09502891
67MP0003077_abnormal_cell_cycle1.08374944
68MP0008875_abnormal_xenobiotic_pharmacok1.08066370
69MP0005584_abnormal_enzyme/coenzyme_acti1.07749255
70MP0001529_abnormal_vocalization1.04313762
71MP0000230_abnormal_systemic_arterial1.03405714
72MP0009379_abnormal_foot_pigmentation1.03287106
73MP0003786_premature_aging1.03056830
74MP0000678_abnormal_parathyroid_gland1.02790278
75MP0004859_abnormal_synaptic_plasticity1.01856903
76MP0002877_abnormal_melanocyte_morpholog1.00687996
77MP0005423_abnormal_somatic_nervous0.98692021
78MP0002249_abnormal_larynx_morphology0.97867005
79MP0003075_altered_response_to0.97672695
80MP0001727_abnormal_embryo_implantation0.94003614
81MP0010329_abnormal_lipoprotein_level0.93649800
82MP0001346_abnormal_lacrimal_gland0.93503910
83MP0009643_abnormal_urine_homeostasis0.91358576
84MP0003011_delayed_dark_adaptation0.88775524
85MP0001905_abnormal_dopamine_level0.88641280
86MP0002234_abnormal_pharynx_morphology0.87175949
87MP0001661_extended_life_span0.85779364
88MP0003567_abnormal_fetal_cardiomyocyte0.84284645
89MP0000013_abnormal_adipose_tissue0.83529330
90MP0000266_abnormal_heart_morphology0.83308590
91MP0002078_abnormal_glucose_homeostasis0.83307381
92MP0002118_abnormal_lipid_homeostasis0.81114091
93MP0003656_abnormal_erythrocyte_physiolo0.79711639
94MP0004147_increased_porphyrin_level0.79363952
95MP0008789_abnormal_olfactory_epithelium0.78637734
96MP0010368_abnormal_lymphatic_system0.78101452
97MP0003191_abnormal_cellular_cholesterol0.77898103
98MP0005375_adipose_tissue_phenotype0.77708964
99MP0003315_abnormal_perineum_morphology0.77472681
100MP0005535_abnormal_body_temperature0.74620177
101MP0003186_abnormal_redox_activity0.73223512
102MP0003329_amyloid_beta_deposits0.72443581
103MP0002971_abnormal_brown_adipose0.72148814
104MP0000313_abnormal_cell_death0.71317052
105MP0005623_abnormal_meninges_morphology0.71316083
106MP0005166_decreased_susceptibility_to0.68472390
107MP0009672_abnormal_birth_weight0.68429502
108MP0001730_embryonic_growth_arrest0.68048932
109MP0003279_aneurysm0.67811522
110MP0009278_abnormal_bone_marrow0.67162519
111MP0009333_abnormal_splenocyte_physiolog0.63991226
112MP0002822_catalepsy0.63770346
113MP0008961_abnormal_basal_metabolism0.63283372
114MP0001853_heart_inflammation0.62289419
115MP0001756_abnormal_urination0.61071042
116MP0005058_abnormal_lysosome_morphology0.60767825
117MP0001666_abnormal_nutrient_absorption0.59233436
118MP0005501_abnormal_skin_physiology0.59188422
119MP0001764_abnormal_homeostasis0.58139477
120MP0000609_abnormal_liver_physiology0.55828685
121MP0005499_abnormal_olfactory_system0.55154990
122MP0005394_taste/olfaction_phenotype0.55154990
123MP0005636_abnormal_mineral_homeostasis0.54910319
124MP0003879_abnormal_hair_cell0.54697442
125MP0005376_homeostasis/metabolism_phenot0.54466222
126MP0002736_abnormal_nociception_after0.53329867
127MP0002128_abnormal_blood_circulation0.53038937
128MP0000681_abnormal_thyroid_gland0.52811545
129MP0001765_abnormal_ion_homeostasis0.51547460
130MP0000358_abnormal_cell_content/0.50992860
131MP0003252_abnormal_bile_duct0.49597614
132MP0005334_abnormal_fat_pad0.48405706
133MP0002108_abnormal_muscle_morphology0.46913698
134MP0004185_abnormal_adipocyte_glucose0.46496356
135MP0009642_abnormal_blood_homeostasis0.44135153
136MP0000003_abnormal_adipose_tissue0.42973347
137MP0003950_abnormal_plasma_membrane0.40855279
138MP0005448_abnormal_energy_balance0.39721822
139MP0003566_abnormal_cell_adhesion0.39247599
140MP0005451_abnormal_body_composition0.38556926
141MP0000598_abnormal_liver_morphology0.37873972
142MP0008469_abnormal_protein_level0.36287988
143MP0005084_abnormal_gallbladder_morpholo0.36116398
144MP0003705_abnormal_hypodermis_morpholog0.35444428
145MP0002970_abnormal_white_adipose0.34083329

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.99616668
2Exercise-induced myalgia (HP:0003738)5.47280263
3Exercise-induced muscle cramps (HP:0003710)5.38337468
4Calf muscle hypertrophy (HP:0008981)5.16831145
5Myoglobinuria (HP:0002913)5.10557126
6Ventricular tachycardia (HP:0004756)5.05318498
7Muscle hypertrophy of the lower extremities (HP:0008968)4.77535996
8Myopathic facies (HP:0002058)4.67672002
9Hepatic necrosis (HP:0002605)4.50569288
10Centrally nucleated skeletal muscle fibers (HP:0003687)4.23941835
11Abnormal mitochondria in muscle tissue (HP:0008316)4.21281664
12Palpitations (HP:0001962)4.20752600
13Atrial fibrillation (HP:0005110)4.18010610
14Hepatocellular necrosis (HP:0001404)4.16910205
15Acute necrotizing encephalopathy (HP:0006965)4.05195794
16Rhabdomyolysis (HP:0003201)4.04146482
17Lipoatrophy (HP:0100578)4.01503362
18Abnormality of the calf musculature (HP:0001430)3.97813883
19Primary atrial arrhythmia (HP:0001692)3.92436984
20Supraventricular tachycardia (HP:0004755)3.87857676
21Supraventricular arrhythmia (HP:0005115)3.78812034
22Acute encephalopathy (HP:0006846)3.76188079
23Muscle fiber splitting (HP:0003555)3.67733638
24Asymmetric septal hypertrophy (HP:0001670)3.65176342
25Mitochondrial inheritance (HP:0001427)3.64356247
26Abnormality of fatty-acid metabolism (HP:0004359)3.63655265
27Increased muscle lipid content (HP:0009058)3.62508277
28Abnormality of the left ventricular outflow tract (HP:0011103)3.60151437
29Subaortic stenosis (HP:0001682)3.60151437
30Dilated cardiomyopathy (HP:0001644)3.59300349
31Right ventricular cardiomyopathy (HP:0011663)3.56891597
32Ketoacidosis (HP:0001993)3.53750018
33Syncope (HP:0001279)3.47068768
34Increased CSF lactate (HP:0002490)3.44425251
35EMG: myopathic abnormalities (HP:0003458)3.39797132
36Ragged-red muscle fibers (HP:0003200)3.37596725
37Cerebral edema (HP:0002181)3.35584612
38Hyporeflexia of lower limbs (HP:0002600)3.35522577
39Hypoglycemic coma (HP:0001325)3.34405322
40Increased intramyocellular lipid droplets (HP:0012240)3.30852386
41Abnormality of dicarboxylic acid metabolism (HP:0010995)3.27207316
42Dicarboxylic aciduria (HP:0003215)3.27207316
43Progressive macrocephaly (HP:0004481)3.26485091
44Bundle branch block (HP:0011710)3.23876613
45Distal lower limb muscle weakness (HP:0009053)3.22823454
46Neck muscle weakness (HP:0000467)3.19540192
47Lactic acidosis (HP:0003128)3.19322618
48Ketosis (HP:0001946)3.11406785
49Prolonged QT interval (HP:0001657)3.05408324
50Ventricular arrhythmia (HP:0004308)3.04844617
51Myotonia (HP:0002486)3.04593883
52Distal arthrogryposis (HP:0005684)3.00068134
53Generalized aminoaciduria (HP:0002909)2.97177204
54Decreased activity of mitochondrial respiratory chain (HP:0008972)2.96998846
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.96998846
56Exercise intolerance (HP:0003546)2.89470673
57Muscle stiffness (HP:0003552)2.89176270
58Microvesicular hepatic steatosis (HP:0001414)2.89007999
59Rimmed vacuoles (HP:0003805)2.88103463
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.87738588
61Heart block (HP:0012722)2.82877042
62Atrioventricular block (HP:0001678)2.81784838
63Hyperammonemia (HP:0001987)2.79112342
64Ventricular fibrillation (HP:0001663)2.72870743
65Increased connective tissue (HP:0009025)2.71156580
66Conjunctival hamartoma (HP:0100780)2.69896202
67Respiratory failure (HP:0002878)2.68820434
68Round ear (HP:0100830)2.66489017
69Abnormal atrioventricular conduction (HP:0005150)2.64257153
70Abnormality of alanine metabolism (HP:0010916)2.63367184
71Hyperalaninemia (HP:0003348)2.63367184
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63367184
73Pheochromocytoma (HP:0002666)2.62340614
74Lipid accumulation in hepatocytes (HP:0006561)2.60478499
75Increased serum pyruvate (HP:0003542)2.58966594
76Abnormality of glycolysis (HP:0004366)2.58966594
77Abnormal gallbladder physiology (HP:0012438)2.58746689
78Cholecystitis (HP:0001082)2.58746689
79Difficulty running (HP:0009046)2.58477380
80Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56958790
81Calcaneovalgus deformity (HP:0001848)2.55901743
82Neuroendocrine neoplasm (HP:0100634)2.55195442
83Muscle fiber inclusion bodies (HP:0100299)2.54896674
84Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.48614179
85Increased serum lactate (HP:0002151)2.47702196
86Hyperglycinuria (HP:0003108)2.46998613
87Distal lower limb amyotrophy (HP:0008944)2.41183190
88Esophageal neoplasm (HP:0100751)2.34624777
89Neoplasm of head and neck (HP:0012288)2.34624777
90Cerebral hypomyelination (HP:0006808)2.31645205
91Abnormal EKG (HP:0003115)2.31550093
92Limb-girdle muscle atrophy (HP:0003797)2.30651065
93Lethargy (HP:0001254)2.30448286
94Left ventricular hypertrophy (HP:0001712)2.29540190
95Emotional lability (HP:0000712)2.28725425
96Metabolic acidosis (HP:0001942)2.26988980
97Difficulty climbing stairs (HP:0003551)2.26265246
98Bulbar palsy (HP:0001283)2.25707932
99Cerebral palsy (HP:0100021)2.23862027
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22613602
101Deformed tarsal bones (HP:0008119)2.20006142
102Increased variability in muscle fiber diameter (HP:0003557)2.18764137
103Neoplasm of the adrenal gland (HP:0100631)2.15645295
104Type 1 muscle fiber predominance (HP:0003803)2.15313145
105Abnormality of serine family amino acid metabolism (HP:0010894)2.14447129
106Abnormality of glycine metabolism (HP:0010895)2.14447129
107Ulnar deviation of the wrist (HP:0003049)2.13050444
108Abnormality of skeletal muscle fiber size (HP:0012084)2.12783051
109Vomiting (HP:0002013)2.12463499
110Increased hepatocellular lipid droplets (HP:0006565)2.11174862
111Nemaline bodies (HP:0003798)2.10437976
112Renal Fanconi syndrome (HP:0001994)2.08089976
113Gout (HP:0001997)2.08070579
114Reduced antithrombin III activity (HP:0001976)2.06278487
115Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05932335
116Type I transferrin isoform profile (HP:0003642)2.02742695
117Nausea (HP:0002018)2.01657353
118Areflexia of lower limbs (HP:0002522)2.01108671
119CNS demyelination (HP:0007305)2.00899374
120Palmoplantar keratoderma (HP:0000982)1.97769442
121Cholelithiasis (HP:0001081)1.97715280
122Multiple enchondromatosis (HP:0005701)1.96136860
123Testicular atrophy (HP:0000029)1.95964554
124Generalized muscle weakness (HP:0003324)1.95628786
125Frequent falls (HP:0002359)1.94774218
126Progressive muscle weakness (HP:0003323)1.94166207
127EMG: neuropathic changes (HP:0003445)1.92411538
128Paralysis (HP:0003470)1.92287749
1293-Methylglutaconic aciduria (HP:0003535)1.87770420
130Opisthotonus (HP:0002179)1.85929345
131Progressive external ophthalmoplegia (HP:0000590)1.84049994
132Athetosis (HP:0002305)1.83987289
133Respiratory insufficiency due to muscle weakness (HP:0002747)1.83581185
134Oligomenorrhea (HP:0000876)1.82922119
135Abnormal gallbladder morphology (HP:0012437)1.81076945
136Abnormality of the foot musculature (HP:0001436)1.76537630
137Myokymia (HP:0002411)1.75062457
138Leukodystrophy (HP:0002415)1.73195209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.83132050
2TTN4.74117263
3VRK24.14931292
4OBSCN4.00275156
5MYLK3.98005575
6PHKG13.45341428
7PHKG23.45341428
8PKN23.43138275
9PDK33.34229200
10PDK43.34229200
11LMTK23.15920403
12TRIB32.83165687
13NEK12.68297305
14BUB12.37634069
15SMG12.06441826
16TIE11.96573479
17STK161.94230449
18PINK11.89927308
19NME21.86778872
20FLT31.81893741
21MUSK1.72621027
22PIK3CA1.69191963
23PDK21.67861521
24MAP3K121.57617011
25MAP2K31.56114558
26DMPK1.52556244
27STK241.45261217
28KDR1.42765438
29ERN11.42419240
30PIM21.41502626
31CCNB11.30217208
32GRK71.28904694
33ILK1.28798478
34PRKD31.25120862
35SRPK11.17531167
36CSNK1G31.16856694
37TAOK21.15490506
38MAPKAPK31.15174928
39ABL21.14546001
40CDK191.14012940
41DAPK31.09313027
42CDC71.08669238
43MAP3K71.08031428
44MAP3K111.02440079
45ARAF1.01317612
46NME11.01064209
47PBK1.00629249
48AURKA0.98777411
49TLK10.95548555
50BRAF0.91674452
51TGFBR20.91218020
52WNK40.91209843
53IRAK30.89828167
54MAP2K40.88805617
55VRK10.85609707
56PAK60.84883453
57CSNK1A1L0.83422460
58MAP2K60.82898972
59MAP3K30.82335641
60MAPK120.80718533
61PRKD10.80264728
62PAK30.79574701
63BRSK10.79033038
64PIK3CG0.78173315
65CAMK2D0.76401100
66CSNK1G20.76009461
67MAP3K50.73199534
68EEF2K0.71392487
69DYRK20.69977153
70LRRK20.68738845
71TGFBR10.67193753
72FGFR40.64827237
73NEK90.64344721
74ZAP700.63642247
75SCYL20.62834337
76SIK10.62371397
77CDK140.62112618
78ROCK10.61276200
79CDK11A0.59244667
80TBK10.59137355
81CSNK1G10.58974250
82EIF2AK10.57936480
83PRPF4B0.55357447
84CAMK10.53757636
85CDK150.52973107
86KIT0.52721853
87PRKAA10.52663220
88CAMK2B0.51879837
89AURKB0.50811529
90PAK10.50713725
91MAPK110.50478646
92TYK20.49974403
93CDK180.48914288
94MAPKAPK50.48278825
95STK38L0.47554242
96PRKG20.46599821
97PLK10.46351007
98RPS6KL10.45878338
99RPS6KC10.45878338
100MAP2K20.45515944
101CDK70.44085045
102RIPK10.43600490
103PRKAA20.43374235
104CAMK2G0.43240724
105MINK10.43221494
106RPS6KA60.42520446
107MAP3K80.42500428
108MAP4K10.41430345
109ICK0.40853927
110RPS6KA50.40839712
111KSR20.40134495
112LIMK10.39717129
113PAK40.38925634
114ATR0.38662236
115TTK0.38264082
116CAMK40.38251185
117DYRK30.37965790
118CHEK20.36283644
119MAP3K10.35089123
120CSNK2A10.34322144
121GRK50.33253077
122MAPK40.32846027
123EPHA20.32633239
124DAPK10.32590373
125PRKACB0.32226479
126MAP3K90.31796048
127PDPK10.30535142
128TESK10.30500167
129STK380.30355052
130PRKACG0.30220080
131PRKACA0.29909822
132MAP2K70.29629176
133CAMK2A0.29118301
134PDK10.28770544
135ZAK0.28684434
136EPHA40.28620192
137CDC42BPA0.28553954
138CSNK2A20.28025488
139TESK20.27483546
140CAMKK20.27269089
141AKT20.27021373
142PTK60.26994954
143IRAK20.26160280
144MAP2K10.26013091
145RAF10.25295395
146DAPK20.24272439
147STK40.24152350
148ROCK20.23943010
149PTK2B0.23878958
150MAP3K130.22348584
151SYK0.22063361
152JAK20.21210951
153PRKCH0.20736785
154TAOK10.20575288
155RET0.20409291

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.05506955
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.57861917
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.63323620
4Propanoate metabolism_Homo sapiens_hsa006403.44167899
5Oxidative phosphorylation_Homo sapiens_hsa001903.38344743
6Parkinsons disease_Homo sapiens_hsa050123.33396199
7Fatty acid degradation_Homo sapiens_hsa000713.16797497
8Cardiac muscle contraction_Homo sapiens_hsa042603.05802127
9Carbon metabolism_Homo sapiens_hsa012002.85026304
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82742879
11DNA replication_Homo sapiens_hsa030302.73004794
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45341244
13Pyruvate metabolism_Homo sapiens_hsa006202.40542471
14Base excision repair_Homo sapiens_hsa034102.36870302
15Alzheimers disease_Homo sapiens_hsa050102.34621278
16Fatty acid metabolism_Homo sapiens_hsa012122.23560519
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.16448727
18Dilated cardiomyopathy_Homo sapiens_hsa054142.01314522
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.94608374
20Huntingtons disease_Homo sapiens_hsa050161.90806120
21Butanoate metabolism_Homo sapiens_hsa006501.85956633
22Mismatch repair_Homo sapiens_hsa034301.74108248
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.72142370
24RNA polymerase_Homo sapiens_hsa030201.70989183
25Pyrimidine metabolism_Homo sapiens_hsa002401.70259584
26Biosynthesis of amino acids_Homo sapiens_hsa012301.70099477
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55499478
28Peroxisome_Homo sapiens_hsa041461.37418545
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34623178
30Fatty acid elongation_Homo sapiens_hsa000621.30456237
31Arginine biosynthesis_Homo sapiens_hsa002201.29178630
32Starch and sucrose metabolism_Homo sapiens_hsa005001.29173253
33Tryptophan metabolism_Homo sapiens_hsa003801.28249699
34beta-Alanine metabolism_Homo sapiens_hsa004101.22880379
35PPAR signaling pathway_Homo sapiens_hsa033201.21197061
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15775162
37Spliceosome_Homo sapiens_hsa030401.12933553
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07273820
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04756939
40Galactose metabolism_Homo sapiens_hsa000521.04330526
41Fructose and mannose metabolism_Homo sapiens_hsa000511.02246871
42Nucleotide excision repair_Homo sapiens_hsa034201.01004945
43Purine metabolism_Homo sapiens_hsa002300.97506599
44Phenylalanine metabolism_Homo sapiens_hsa003600.93642097
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93045977
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92729428
47Synaptic vesicle cycle_Homo sapiens_hsa047210.92545839
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89232439
49Homologous recombination_Homo sapiens_hsa034400.87255561
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84093627
51Pentose phosphate pathway_Homo sapiens_hsa000300.81517188
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.81366605
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80494921
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.80198412
55Glucagon signaling pathway_Homo sapiens_hsa049220.79343877
56Insulin resistance_Homo sapiens_hsa049310.75235101
57Arginine and proline metabolism_Homo sapiens_hsa003300.70519252
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69456917
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.69153857
60One carbon pool by folate_Homo sapiens_hsa006700.69109373
61Viral myocarditis_Homo sapiens_hsa054160.68809273
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66912599
63Insulin signaling pathway_Homo sapiens_hsa049100.65472047
64Vitamin B6 metabolism_Homo sapiens_hsa007500.61669185
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61267166
66Other glycan degradation_Homo sapiens_hsa005110.58259894
67Proteasome_Homo sapiens_hsa030500.58118509
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57924579
69Sulfur relay system_Homo sapiens_hsa041220.56385485
70Metabolic pathways_Homo sapiens_hsa011000.54899038
71Caffeine metabolism_Homo sapiens_hsa002320.51279390
72Tyrosine metabolism_Homo sapiens_hsa003500.49545187
73Ribosome_Homo sapiens_hsa030100.49085983
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48722692
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48680283
76Fat digestion and absorption_Homo sapiens_hsa049750.48303645
77RNA transport_Homo sapiens_hsa030130.47957583
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44843560
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.44235874
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43095817
81Sulfur metabolism_Homo sapiens_hsa009200.42996363
82Non-homologous end-joining_Homo sapiens_hsa034500.42464545
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.40383812
84Bile secretion_Homo sapiens_hsa049760.39968074
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.37985798
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37303528
87AMPK signaling pathway_Homo sapiens_hsa041520.37282329
88Folate biosynthesis_Homo sapiens_hsa007900.37184020
89Calcium signaling pathway_Homo sapiens_hsa040200.36591634
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36506672
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36499425
92Fanconi anemia pathway_Homo sapiens_hsa034600.36109198
93Nitrogen metabolism_Homo sapiens_hsa009100.35957594
94HIF-1 signaling pathway_Homo sapiens_hsa040660.34060516
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33111162
96Chemical carcinogenesis_Homo sapiens_hsa052040.30622046
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30274682
98Glutathione metabolism_Homo sapiens_hsa004800.28651397
99Shigellosis_Homo sapiens_hsa051310.23691963
100Lysosome_Homo sapiens_hsa041420.23242628
101Collecting duct acid secretion_Homo sapiens_hsa049660.23096678
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22613242
103Glycerolipid metabolism_Homo sapiens_hsa005610.22590856
104Epstein-Barr virus infection_Homo sapiens_hsa051690.22553536
105Oocyte meiosis_Homo sapiens_hsa041140.22528486
106Oxytocin signaling pathway_Homo sapiens_hsa049210.22311254
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21695733
108Cell cycle_Homo sapiens_hsa041100.19540658
109Renin secretion_Homo sapiens_hsa049240.17936125
110Lysine degradation_Homo sapiens_hsa003100.17320369
111Alcoholism_Homo sapiens_hsa050340.16199594
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13986967
113Insulin secretion_Homo sapiens_hsa049110.13583314
114Gastric acid secretion_Homo sapiens_hsa049710.13493898
115N-Glycan biosynthesis_Homo sapiens_hsa005100.12605059
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12385796
117Vibrio cholerae infection_Homo sapiens_hsa051100.12318730
118Systemic lupus erythematosus_Homo sapiens_hsa053220.11160726
119Prion diseases_Homo sapiens_hsa050200.10943440
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.10397735
121Salmonella infection_Homo sapiens_hsa051320.08169827
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.07387159
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.05416386
124Selenocompound metabolism_Homo sapiens_hsa004500.05381427
125Regulation of autophagy_Homo sapiens_hsa041400.05381106
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04917940
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04638112
128Bladder cancer_Homo sapiens_hsa052190.04053918
129Circadian entrainment_Homo sapiens_hsa047130.03476052
130ABC transporters_Homo sapiens_hsa020100.03403017
131Fatty acid biosynthesis_Homo sapiens_hsa000610.01526730
132Type II diabetes mellitus_Homo sapiens_hsa049300.00346921
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.00281446
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0219680
135cAMP signaling pathway_Homo sapiens_hsa04024-0.0214720
136Histidine metabolism_Homo sapiens_hsa00340-0.0030146

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