SLC25A12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)7.67707692
2actin filament-based movement (GO:0030048)5.66139722
3response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.35934912
4creatine metabolic process (GO:0006600)4.95906646
5cardiac muscle hypertrophy (GO:0003300)4.77579754
6response to inactivity (GO:0014854)4.62745036
7actomyosin structure organization (GO:0031032)4.60559800
8striated muscle hypertrophy (GO:0014897)4.56644706
9neuronal action potential propagation (GO:0019227)4.49838593
10muscle contraction (GO:0006936)4.48727899
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.47692586
12synaptic vesicle exocytosis (GO:0016079)4.43893656
13vocalization behavior (GO:0071625)4.43066015
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.38145843
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.31661211
16regulation of striated muscle contraction (GO:0006942)4.29713836
17response to muscle activity (GO:0014850)4.28159546
18sarcoplasmic reticulum calcium ion transport (GO:0070296)4.27233262
19regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.20486245
20synaptic vesicle maturation (GO:0016188)4.14106324
21skeletal muscle adaptation (GO:0043501)4.11997178
22regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.10012416
23regulation of cell communication by electrical coupling (GO:0010649)4.07427692
24muscle system process (GO:0003012)4.05554841
25neuron cell-cell adhesion (GO:0007158)4.04892531
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.04569272
27regulation of synaptic vesicle exocytosis (GO:2000300)4.01189748
28heart contraction (GO:0060047)3.96984493
29heart process (GO:0003015)3.96984493
30muscle hypertrophy (GO:0014896)3.94610510
31positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.92203739
32positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.90954395
33skeletal muscle fiber development (GO:0048741)3.90680247
34NADH metabolic process (GO:0006734)3.85205816
35muscle fiber development (GO:0048747)3.79816368
36regulation of synaptic vesicle transport (GO:1902803)3.79756363
37negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.78610687
38negative regulation of calcium ion transmembrane transport (GO:1903170)3.78610687
39positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.77535524
40glutamate secretion (GO:0014047)3.77339842
41regulation of glutamate receptor signaling pathway (GO:1900449)3.76468128
42myotube cell development (GO:0014904)3.76150460
43regulation of synapse structural plasticity (GO:0051823)3.74037901
44locomotory exploration behavior (GO:0035641)3.71323147
45protein localization to synapse (GO:0035418)3.68761139
46cardiac muscle tissue morphogenesis (GO:0055008)3.68523878
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.65333579
48striated muscle adaptation (GO:0014888)3.65163982
49glycogen catabolic process (GO:0005980)3.65059387
50regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.64689018
51regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.64640616
52regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.64505149
53muscle cell cellular homeostasis (GO:0046716)3.59839722
54muscle tissue morphogenesis (GO:0060415)3.59104645
55relaxation of muscle (GO:0090075)3.56892644
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.55699762
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.53683275
58synaptic vesicle docking involved in exocytosis (GO:0016081)3.51930168
59regulation of the force of heart contraction (GO:0002026)3.50394447
60adult heart development (GO:0007512)3.50323209
61positive regulation of cation channel activity (GO:2001259)3.49409188
62ionotropic glutamate receptor signaling pathway (GO:0035235)3.48127526
63regulation of cardiac muscle cell contraction (GO:0086004)3.47880248
64detection of calcium ion (GO:0005513)3.47427210
65muscle filament sliding (GO:0030049)3.45912800
66actin-myosin filament sliding (GO:0033275)3.45912800
67neurotransmitter secretion (GO:0007269)3.44638953
68regulation of relaxation of muscle (GO:1901077)3.43652448
69negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.43140943
70relaxation of cardiac muscle (GO:0055119)3.42186392
71positive regulation of potassium ion transmembrane transport (GO:1901381)3.40532888
72regulation of calcium ion transmembrane transporter activity (GO:1901019)3.38395055
73regulation of calcium ion transmembrane transport (GO:1903169)3.38395055
74negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.36992278
75regulation of membrane repolarization (GO:0060306)3.36713767
76cellular potassium ion homeostasis (GO:0030007)3.36520490
77regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.35510612
78glucan catabolic process (GO:0009251)3.34961963
79cardiac muscle cell development (GO:0055013)3.34690589
80membrane depolarization during action potential (GO:0086010)3.34619996
81cardiac muscle hypertrophy in response to stress (GO:0014898)3.34314144
82muscle hypertrophy in response to stress (GO:0003299)3.34314144
83cardiac muscle adaptation (GO:0014887)3.34314144
84sarcomere organization (GO:0045214)3.26383240
85neuron-neuron synaptic transmission (GO:0007270)3.24955497
86regulation of acyl-CoA biosynthetic process (GO:0050812)3.23321735
87negative regulation of potassium ion transmembrane transport (GO:1901380)3.23320359
88cell communication by electrical coupling (GO:0010644)3.22244345
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.22111066
90positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.21655835
91activation of protein kinase A activity (GO:0034199)3.20735290
92regulation of ATPase activity (GO:0043462)3.19898329
93regulation of ATP catabolic process (GO:1903289)3.19898329
94glutamate receptor signaling pathway (GO:0007215)3.17197524
95glycogen biosynthetic process (GO:0005978)3.16918607
96glucan biosynthetic process (GO:0009250)3.16918607
97cardiac muscle contraction (GO:0060048)3.15134324
98potassium ion import (GO:0010107)3.14258598
99ventricular cardiac muscle cell action potential (GO:0086005)3.11748961
100regulation of sarcomere organization (GO:0060297)3.11732277
101regulation of skeletal muscle contraction (GO:0014819)3.11279352
102striated muscle cell development (GO:0055002)3.10841562
103regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.10838231
104skeletal muscle tissue development (GO:0007519)3.10103210
105synaptic transmission, glutamatergic (GO:0035249)3.09316998
106gamma-aminobutyric acid signaling pathway (GO:0007214)3.09153791
107exploration behavior (GO:0035640)3.09029507
108tricarboxylic acid cycle (GO:0006099)3.08517512
109cellular polysaccharide catabolic process (GO:0044247)3.07843514
110mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06957032
111striated muscle contraction (GO:0006941)3.06115973
112cardiac cell development (GO:0055006)3.05368607
113negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04025164
114plasma membrane repair (GO:0001778)3.04010177
115regulation of muscle system process (GO:0090257)3.02746480
116regulation of coenzyme metabolic process (GO:0051196)3.01872009
117regulation of cofactor metabolic process (GO:0051193)3.01872009
118regulation of neuronal synaptic plasticity (GO:0048168)3.01523502
119regulation of actin filament-based movement (GO:1903115)3.00425925
120cardiac muscle cell action potential (GO:0086001)2.99615880
121neuromuscular process controlling posture (GO:0050884)2.98877192
122ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.98455183
123mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98021873
124positive regulation of synapse maturation (GO:0090129)2.97698076
125regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96905429
126neuron recognition (GO:0008038)2.95178964
127skeletal muscle contraction (GO:0003009)2.94430554
128regulation of cardiac muscle contraction (GO:0055117)2.94168629
129regulation of potassium ion transmembrane transporter activity (GO:1901016)2.93347039
130negative regulation of potassium ion transport (GO:0043267)2.91734387
131myofibril assembly (GO:0030239)2.91522258
132regulation of sodium ion transmembrane transport (GO:1902305)2.91355428
133regulation of excitatory postsynaptic membrane potential (GO:0060079)2.90528745
134neurotransmitter transport (GO:0006836)2.90490058
135regulation of muscle contraction (GO:0006937)2.90137558
136positive regulation of ion transmembrane transporter activity (GO:0032414)2.88943856
137sodium ion export (GO:0071436)2.88241060
138neurotransmitter-gated ion channel clustering (GO:0072578)2.87886124
139synaptic vesicle endocytosis (GO:0048488)2.87084539
140regulation of skeletal muscle cell differentiation (GO:2001014)2.87074079
141regulation of cation channel activity (GO:2001257)2.86376007
142regulation of voltage-gated calcium channel activity (GO:1901385)2.86099621
143cell communication involved in cardiac conduction (GO:0086065)2.83059458
144response to pheromone (GO:0019236)2.82657802
145long-term memory (GO:0007616)2.82568093
146neuromuscular synaptic transmission (GO:0007274)2.81874696
147positive regulation of potassium ion transport (GO:0043268)2.81463916
148postsynaptic membrane organization (GO:0001941)2.80754815
149membrane depolarization (GO:0051899)2.80447489
150regulation of postsynaptic membrane potential (GO:0060078)2.78897182
151cardiac myofibril assembly (GO:0055003)2.78300506
152ATP hydrolysis coupled proton transport (GO:0015991)2.78048810
153energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.78048810
154regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77112731
155gamma-aminobutyric acid transport (GO:0015812)2.76780692
156regulation of potassium ion transmembrane transport (GO:1901379)2.75950890
157cerebellar Purkinje cell differentiation (GO:0021702)2.75593168
158regulation of ion transmembrane transporter activity (GO:0032412)2.74069984
159negative regulation of protein localization to cell surface (GO:2000009)2.73196553
160energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72981677
161ATP synthesis coupled proton transport (GO:0015986)2.72981677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.43765827
2GBX2_23144817_ChIP-Seq_PC3_Human3.73056605
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11213147
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99043241
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.98694824
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86455061
7REST_21632747_ChIP-Seq_MESCs_Mouse2.65324799
8* RARB_27405468_Chip-Seq_BRAIN_Mouse2.55512220
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.50528317
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.49828606
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47664330
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46106997
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45893590
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45893590
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42130576
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42007678
17DROSHA_22980978_ChIP-Seq_HELA_Human2.41506502
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40184100
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.38132588
20TAF15_26573619_Chip-Seq_HEK293_Human2.33665318
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26841217
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19049116
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18741525
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.17509050
25* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.14711634
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13329871
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02379513
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.97340831
29AR_21572438_ChIP-Seq_LNCaP_Human1.95015164
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93261978
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.89577650
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88036580
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77998575
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76826299
35MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.75982669
36SMAD4_21799915_ChIP-Seq_A2780_Human1.70774386
37TBX20_22080862_ChIP-Seq_HEART_Mouse1.62825168
38TBX20_22328084_ChIP-Seq_HEART_Mouse1.62825168
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.62106843
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61786463
41ZNF274_21170338_ChIP-Seq_K562_Hela1.60338130
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56938688
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53897475
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.53066917
45IGF1R_20145208_ChIP-Seq_DFB_Human1.51566881
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49625767
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44746498
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43932778
49* SOX2_21211035_ChIP-Seq_LN229_Gbm1.42502433
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39614359
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39241975
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38438687
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33910953
54* P300_19829295_ChIP-Seq_ESCs_Human1.33657055
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33339704
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.29626488
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.29011367
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28644286
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28432443
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.27587740
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23957959
62AR_25329375_ChIP-Seq_VCAP_Human1.23634325
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23474300
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22641635
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22293194
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21483241
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.20977134
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20793539
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19702924
70GATA4_21415370_ChIP-Seq_HL-1_Mouse1.19503294
71VDR_22108803_ChIP-Seq_LS180_Human1.19451092
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19378496
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18555776
74ER_23166858_ChIP-Seq_MCF-7_Human1.15595307
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.14891747
76SOX9_26525672_Chip-Seq_HEART_Mouse1.14641198
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14523714
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.14262299
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13293841
80AR_19668381_ChIP-Seq_PC3_Human1.13098686
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12228371
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.11655451
83* P53_22387025_ChIP-Seq_ESCs_Mouse1.10657255
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10562147
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.09930201
86STAT3_23295773_ChIP-Seq_U87_Human1.08903349
87* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07623980
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06580775
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06072967
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05892469
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05802543
92* E2F1_18555785_Chip-Seq_ESCs_Mouse1.05296307
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05291187
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.05015523
95* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04026259
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03476270
97* NANOG_18555785_Chip-Seq_ESCs_Mouse1.03305899
98* TCF4_23295773_ChIP-Seq_U87_Human1.02785066
99* PRDM14_20953172_ChIP-Seq_ESCs_Human1.02752847
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01859878
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00393991
102* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99343038
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99162979
104HTT_18923047_ChIP-ChIP_STHdh_Human0.99053350
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98583472
106* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97347967
107* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94318100
108PIAS1_25552417_ChIP-Seq_VCAP_Human0.93908590
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93878715
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93143044
111CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93024527
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92229744
113RNF2_27304074_Chip-Seq_NSC_Mouse0.91976235
114SMAD_19615063_ChIP-ChIP_OVARY_Human0.91571156
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90413969
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89227124
117WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89112695
118EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88207516
119* RUNX2_22187159_ChIP-Seq_PCA_Human0.87754792
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87555365
121FUS_26573619_Chip-Seq_HEK293_Human0.87188613
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86252448
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.85064614
124CTCF_27219007_Chip-Seq_Bcells_Human0.84964256
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83684849
126CBP_20019798_ChIP-Seq_JUKART_Human0.83684849
127FLI1_21867929_ChIP-Seq_TH2_Mouse0.83625095
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82690049
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.82611689
130JUN_21703547_ChIP-Seq_K562_Human0.81950073
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80420328
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80341930
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.77730690
134* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.77478133
135GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77048347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.52414249
2MP0003880_abnormal_central_pattern3.98504020
3MP0002837_dystrophic_cardiac_calcinosis3.84919625
4MP0000751_myopathy3.52251120
5MP0003646_muscle_fatigue3.37590164
6MP0003635_abnormal_synaptic_transmissio3.14721875
7MP0004270_analgesia3.00075081
8MP0004145_abnormal_muscle_electrophysio2.95452577
9MP0009745_abnormal_behavioral_response2.67738442
10MP0000749_muscle_degeneration2.56824478
11* MP0002064_seizures2.54912338
12MP0009046_muscle_twitch2.52980271
13MP0002063_abnormal_learning/memory/cond2.50829852
14MP0004036_abnormal_muscle_relaxation2.47041475
15MP0001968_abnormal_touch/_nociception2.38664269
16MP0004215_abnormal_myocardial_fiber2.37513681
17MP0002272_abnormal_nervous_system2.25895308
18MP0004084_abnormal_cardiac_muscle2.15895829
19MP0002572_abnormal_emotion/affect_behav2.15067451
20MP0005451_abnormal_body_composition2.13523625
21MP0002822_catalepsy2.08696217
22MP0002734_abnormal_mechanical_nocicepti2.07085831
23MP0001529_abnormal_vocalization2.00967356
24MP0006276_abnormal_autonomic_nervous1.96868905
25MP0002735_abnormal_chemical_nociception1.96390530
26MP0005423_abnormal_somatic_nervous1.94766295
27MP0001486_abnormal_startle_reflex1.92695853
28MP0002736_abnormal_nociception_after1.83632150
29MP0001440_abnormal_grooming_behavior1.81681225
30MP0000747_muscle_weakness1.78281774
31MP0002067_abnormal_sensory_capabilities1.77432418
32MP0008569_lethality_at_weaning1.72749559
33MP0001501_abnormal_sleep_pattern1.71689527
34MP0002106_abnormal_muscle_physiology1.70786538
35MP0005620_abnormal_muscle_contractility1.68925226
36MP0001970_abnormal_pain_threshold1.65606806
37MP0003137_abnormal_impulse_conducting1.65013751
38MP0002733_abnormal_thermal_nociception1.61852357
39MP0004142_abnormal_muscle_tone1.58890567
40MP0005386_behavior/neurological_phenoty1.57073970
41MP0004924_abnormal_behavior1.57073970
42MP0003122_maternal_imprinting1.55451292
43MP0004130_abnormal_muscle_cell1.55171937
44MP0003329_amyloid_beta_deposits1.54668219
45MP0004233_abnormal_muscle_weight1.53772123
46MP0005330_cardiomyopathy1.53089464
47MP0005646_abnormal_pituitary_gland1.52101874
48MP0002909_abnormal_adrenal_gland1.51154930
49MP0004087_abnormal_muscle_fiber1.47895789
50MP0002127_abnormal_cardiovascular_syste1.47556280
51MP0000759_abnormal_skeletal_muscle1.45490710
52MP0004484_altered_response_of1.45406187
53MP0005369_muscle_phenotype1.44511972
54MP0010630_abnormal_cardiac_muscle1.44506964
55MP0002972_abnormal_cardiac_muscle1.44326420
56MP0005645_abnormal_hypothalamus_physiol1.41490382
57MP0004085_abnormal_heartbeat1.38839224
58MP0002184_abnormal_innervation1.37301315
59MP0001905_abnormal_dopamine_level1.37179971
60MP0002269_muscular_atrophy1.35532574
61MP0002108_abnormal_muscle_morphology1.34818398
62MP0009780_abnormal_chondrocyte_physiolo1.32495807
63MP0004811_abnormal_neuron_physiology1.29187541
64MP0002557_abnormal_social/conspecific_i1.27894296
65MP0000733_abnormal_muscle_development1.26053224
66* MP0002066_abnormal_motor_capabilities/c1.22667242
67MP0000013_abnormal_adipose_tissue1.22458849
68MP0000778_abnormal_nervous_system1.21662662
69MP0004043_abnormal_pH_regulation1.20426573
70MP0001984_abnormal_olfaction1.19786715
71MP0002332_abnormal_exercise_endurance1.13652441
72MP0000955_abnormal_spinal_cord1.09667677
73MP0003633_abnormal_nervous_system1.09036077
74MP0001502_abnormal_circadian_rhythm1.08990954
75MP0005266_abnormal_metabolism1.08919571
76MP0002882_abnormal_neuron_morphology1.07420254
77MP0003879_abnormal_hair_cell1.06391283
78MP0003950_abnormal_plasma_membrane1.06183435
79MP0000750_abnormal_muscle_regeneration1.04260200
80MP0004858_abnormal_nervous_system1.03761285
81* MP0006036_abnormal_mitochondrial_physio0.99940369
82MP0008775_abnormal_heart_ventricle0.96600664
83MP0002638_abnormal_pupillary_reflex0.95965427
84MP0002229_neurodegeneration0.95861404
85MP0004510_myositis0.94614842
86MP0006035_abnormal_mitochondrial_morpho0.93193764
87MP0003787_abnormal_imprinting0.89223103
88MP0003631_nervous_system_phenotype0.88177202
89MP0001544_abnormal_cardiovascular_syste0.86431823
90MP0005385_cardiovascular_system_phenoty0.86431823
91MP0005670_abnormal_white_adipose0.85600005
92MP0005535_abnormal_body_temperature0.85551736
93* MP0000920_abnormal_myelination0.84545356
94MP0005551_abnormal_eye_electrophysiolog0.80049777
95MP0002971_abnormal_brown_adipose0.74699500
96MP0003634_abnormal_glial_cell0.74272589
97MP0001299_abnormal_eye_distance/0.72596015
98MP0000372_irregular_coat_pigmentation0.72340688
99MP0006138_congestive_heart_failure0.72194639
100MP0001661_extended_life_span0.72159110
101MP0004885_abnormal_endolymph0.71914581
102MP0003221_abnormal_cardiomyocyte_apopto0.71814617
103MP0010386_abnormal_urinary_bladder0.70728168
104MP0008874_decreased_physiological_sensi0.70235490
105MP0002069_abnormal_eating/drinking_beha0.69866430
106MP0003183_abnormal_peptide_metabolism0.69580040
107MP0004742_abnormal_vestibular_system0.67218308
108* MP0002152_abnormal_brain_morphology0.66882362
109MP0008961_abnormal_basal_metabolism0.65767751
110MP0005666_abnormal_adipose_tissue0.65167729
111MP0001188_hyperpigmentation0.64687671
112MP0003828_pulmonary_edema0.64675161
113MP0004147_increased_porphyrin_level0.63396185
114MP0000230_abnormal_systemic_arterial0.59934757
115MP0003045_fibrosis0.59077077
116MP0000266_abnormal_heart_morphology0.55883295
117MP0005187_abnormal_penis_morphology0.55095512
118MP0005375_adipose_tissue_phenotype0.52672210
119MP0001986_abnormal_taste_sensitivity0.50712215
120MP0000003_abnormal_adipose_tissue0.50046636
121MP0001943_abnormal_respiration0.45680767
122MP0006072_abnormal_retinal_apoptosis0.44078022
123MP0002234_abnormal_pharynx_morphology0.41201076
124MP0004134_abnormal_chest_morphology0.40893732

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.78936844
2Exercise-induced myalgia (HP:0003738)5.38576140
3Muscle hypertrophy of the lower extremities (HP:0008968)4.91594171
4Calf muscle hypertrophy (HP:0008981)4.66488676
5Exercise-induced muscle cramps (HP:0003710)4.59655940
6Rhabdomyolysis (HP:0003201)4.27082253
7Myokymia (HP:0002411)4.16946171
8Sudden death (HP:0001699)4.09350680
9Visual hallucinations (HP:0002367)3.90308174
10Focal seizures (HP:0007359)3.87517911
11Muscle fiber inclusion bodies (HP:0100299)3.81413572
12Centrally nucleated skeletal muscle fibers (HP:0003687)3.75669346
13Round ear (HP:0100830)3.68432090
14Atonic seizures (HP:0010819)3.64069038
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.62972198
16Abnormality of the calf musculature (HP:0001430)3.56476685
17Epileptic encephalopathy (HP:0200134)3.47286317
18Febrile seizures (HP:0002373)3.46311047
19Frequent falls (HP:0002359)3.44672730
20Pheochromocytoma (HP:0002666)3.43169809
21Myotonia (HP:0002486)3.42433262
22Muscle fiber splitting (HP:0003555)3.41848315
23Nemaline bodies (HP:0003798)3.34443748
24Ulnar deviation of the wrist (HP:0003049)3.31391218
25Absence seizures (HP:0002121)3.23501846
26EMG: neuropathic changes (HP:0003445)3.19874038
27EMG: myopathic abnormalities (HP:0003458)3.17860308
28Neuroendocrine neoplasm (HP:0100634)3.13521168
29Calcaneovalgus deformity (HP:0001848)3.11054337
30Difficulty running (HP:0009046)3.06456957
31Absent phalangeal crease (HP:0006109)3.03993357
32Dialeptic seizures (HP:0011146)3.00703023
33Increased connective tissue (HP:0009025)3.00241761
34Dilated cardiomyopathy (HP:0001644)2.99932564
35Distal lower limb muscle weakness (HP:0009053)2.98875267
36Abnormal mitochondria in muscle tissue (HP:0008316)2.97435758
37Generalized tonic-clonic seizures (HP:0002069)2.96559292
38Myoglobinuria (HP:0002913)2.95971487
39Atrial fibrillation (HP:0005110)2.90523078
40Acute necrotizing encephalopathy (HP:0006965)2.89480348
41Broad-based gait (HP:0002136)2.87357939
42Primary atrial arrhythmia (HP:0001692)2.85414022
43Hyporeflexia of lower limbs (HP:0002600)2.85304184
44Lipoatrophy (HP:0100578)2.82230540
45Deformed tarsal bones (HP:0008119)2.81814479
46Prolonged QT interval (HP:0001657)2.79094151
47Supraventricular tachycardia (HP:0004755)2.74670218
48Bundle branch block (HP:0011710)2.73988848
49Areflexia of lower limbs (HP:0002522)2.72183575
50Syncope (HP:0001279)2.69817026
51Ventricular fibrillation (HP:0001663)2.69539098
52Ankle clonus (HP:0011448)2.67707826
53Progressive cerebellar ataxia (HP:0002073)2.67626239
54Supraventricular arrhythmia (HP:0005115)2.63624607
55Abnormal EKG (HP:0003115)2.63454742
56Abnormal finger flexion creases (HP:0006143)2.59304394
57Muscle stiffness (HP:0003552)2.58088713
58Hyperventilation (HP:0002883)2.52634871
59Progressive macrocephaly (HP:0004481)2.52250021
60Limb-girdle muscle atrophy (HP:0003797)2.51370971
61Abnormal atrioventricular conduction (HP:0005150)2.50701041
62Generalized muscle weakness (HP:0003324)2.49941389
63Abnormality of the foot musculature (HP:0001436)2.49607003
64Truncal ataxia (HP:0002078)2.49044267
65Myopathic facies (HP:0002058)2.47647763
66Mitochondrial inheritance (HP:0001427)2.46121924
67Type 1 muscle fiber predominance (HP:0003803)2.45890048
68Distal arthrogryposis (HP:0005684)2.45702121
69Anxiety (HP:0000739)2.43296458
70Supranuclear gaze palsy (HP:0000605)2.40633631
71Urinary urgency (HP:0000012)2.39864836
72Mildly elevated creatine phosphokinase (HP:0008180)2.38743633
73Depression (HP:0000716)2.36893392
74Impaired vibration sensation in the lower limbs (HP:0002166)2.36875038
75Rimmed vacuoles (HP:0003805)2.33342787
76Subaortic stenosis (HP:0001682)2.32315433
77Abnormality of the left ventricular outflow tract (HP:0011103)2.32315433
78Progressive inability to walk (HP:0002505)2.31938697
79Distal lower limb amyotrophy (HP:0008944)2.30851639
80Scapular winging (HP:0003691)2.29685877
81Hepatocellular necrosis (HP:0001404)2.29600719
82Ventricular tachycardia (HP:0004756)2.28299822
83Left ventricular hypertrophy (HP:0001712)2.27484841
84Foot dorsiflexor weakness (HP:0009027)2.26314310
85Dysmetria (HP:0001310)2.22357314
86Malignant hyperthermia (HP:0002047)2.21220184
87Acute encephalopathy (HP:0006846)2.20322670
88Urinary bladder sphincter dysfunction (HP:0002839)2.19615486
89Dysdiadochokinesis (HP:0002075)2.18839561
90Failure to thrive in infancy (HP:0001531)2.17122685
91Abnormal eating behavior (HP:0100738)2.16261345
92Proximal amyotrophy (HP:0007126)2.15556030
93Gaze-evoked nystagmus (HP:0000640)2.13890560
94Increased CSF lactate (HP:0002490)2.13751455
95Ragged-red muscle fibers (HP:0003200)2.13245033
96Increased variability in muscle fiber diameter (HP:0003557)2.12830629
97Ventricular arrhythmia (HP:0004308)2.11988762
98Abnormality of the hip-girdle musculature (HP:0001445)2.11626608
99Abnormality of the musculature of the pelvis (HP:0001469)2.11626608
100Action tremor (HP:0002345)2.09882893
101Fetal akinesia sequence (HP:0001989)2.09842381
102Abnormality of skeletal muscle fiber size (HP:0012084)2.08448571
103Difficulty climbing stairs (HP:0003551)2.07394984
104* Poor eye contact (HP:0000817)2.06175415
105Neck muscle weakness (HP:0000467)2.05421114
106Shoulder girdle muscle weakness (HP:0003547)2.05113910
107Dysmetric saccades (HP:0000641)2.04135312
108Muscular dystrophy (HP:0003560)2.03036489
109Asymmetric septal hypertrophy (HP:0001670)2.01773478
110Polyphagia (HP:0002591)2.01697969
111Bulbar palsy (HP:0001283)2.00095931
112Abnormality of glycolysis (HP:0004366)1.99829477
113Increased serum pyruvate (HP:0003542)1.99829477
114Termporal pattern (HP:0011008)1.99544910
115Insidious onset (HP:0003587)1.99544910
116Lower limb amyotrophy (HP:0007210)1.98520216
117Weak cry (HP:0001612)1.98360288
118Palpitations (HP:0001962)1.97994813
119Progressive muscle weakness (HP:0003323)1.97976956
120Gowers sign (HP:0003391)1.97215390
121Neoplasm of the peripheral nervous system (HP:0100007)1.96845076
122Slender build (HP:0001533)1.94471358
123Abnormality of the shoulder girdle musculature (HP:0001435)1.94259294
124Limb-girdle muscle weakness (HP:0003325)1.93653807
125Respiratory insufficiency due to muscle weakness (HP:0002747)1.92839468
126Abnormality of alanine metabolism (HP:0010916)1.90768383
127Hyperalaninemia (HP:0003348)1.90768383
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90768383
129Postural instability (HP:0002172)1.90557411
130Lower limb muscle weakness (HP:0007340)1.90367270
131Heart block (HP:0012722)1.89567776
132Spastic gait (HP:0002064)1.89257878
133Exercise intolerance (HP:0003546)1.88355967
134* Impaired social interactions (HP:0000735)1.87866990
135* Abnormal social behavior (HP:0012433)1.87866990
136Rapidly progressive (HP:0003678)1.86672128
137Hepatic necrosis (HP:0002605)1.86667118
138Agitation (HP:0000713)1.86642872
139Pelvic girdle muscle weakness (HP:0003749)1.82608882
140Spinal rigidity (HP:0003306)1.81483853
141Hip contracture (HP:0003273)1.81066578
142Atrioventricular block (HP:0001678)1.78232657
143Hyperkalemia (HP:0002153)1.75991036
144Steppage gait (HP:0003376)1.71631176
145Waddling gait (HP:0002515)1.70215453
146Abnormality of the neuromuscular junction (HP:0003398)1.68261114
147Fatigable weakness (HP:0003473)1.68261114
148Increased intramyocellular lipid droplets (HP:0012240)1.66336997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.46839561
2PHKG23.30318725
3PHKG13.30318725
4OBSCN3.05129357
5MAP3K122.85147321
6MAP3K42.78701709
7EPHA42.78101473
8CASK2.54488640
9MAP3K92.38479487
10MAP2K72.26309747
11MARK12.20154108
12TTN2.13867175
13MINK12.12458871
14MAP2K41.94649461
15CDK191.89784097
16PAK61.75161392
17NTRK21.70534253
18RIPK41.65869468
19PINK11.59890473
20NME11.59537367
21LMTK21.52434916
22NEK11.47031817
23PDK41.43387274
24PDK31.43387274
25OXSR11.42028351
26UHMK11.33340871
27SIK31.32379082
28CDK51.28313167
29DAPK21.27268275
30PLK21.27109384
31GRK51.16211238
32DAPK11.14838509
33DMPK1.14082377
34CAMKK21.14070571
35MUSK1.13286956
36MAPKAPK31.13151873
37WNK31.13102898
38CAMK2A1.12952501
39KSR21.12783966
40MAPK131.12676438
41PRPF4B1.09997458
42FES1.05611269
43NTRK11.05499831
44MYLK1.03621906
45ERBB31.01725718
46KSR11.01314639
47CAMKK10.99381319
48GRK70.97940603
49CAMK2D0.97883373
50STK390.95686276
51PRKCG0.94547015
52ARAF0.94412875
53CAMK2B0.93056043
54PIK3CA0.90394469
55TNIK0.88998999
56SGK2230.88337386
57SGK4940.88337386
58MAPK120.84118649
59CCNB10.83638632
60CAMK40.83037797
61WNK40.82852761
62PRKAA10.82689846
63PAK30.82453704
64TRPM70.81485212
65PNCK0.78276162
66MAP2K30.75716187
67WNK10.75661111
68PRKCH0.73999702
69LIMK10.73955763
70CAMK10.73509936
71PRKD30.73432972
72CAMK2G0.72355182
73TNK20.72149921
74PRKCE0.71657245
75MAP3K70.71276414
76SIK20.70386526
77PRKAA20.69193374
78NEK90.69110260
79CDK180.68880882
80BCR0.67218831
81PKN10.66988131
82MAPK70.65295544
83PDK20.64985046
84STK380.63958407
85CDK140.62414940
86PRKG10.61696992
87CDK150.61675066
88ROCK20.60986432
89RET0.60462179
90MAP2K60.60018028
91PDPK10.59699831
92MAP3K50.59500881
93PIK3CG0.59463114
94PTK2B0.58975940
95MAPKAPK50.57569019
96PDK10.57491345
97SGK20.57249948
98SGK10.57248544
99MAP3K10.52530273
100MAP3K60.52047292
101CDK11A0.50262836
102AKT20.49795184
103LATS20.48770006
104MAP2K10.48111306
105STK110.46639237
106PRKACA0.45834374
107MAPK40.45604820
108AKT30.44361902
109MARK20.43719517
110MAPK100.43461959
111DAPK30.41810663
112RAF10.41773855
113SGK30.41555771
114TAOK10.41186544
115PRKACB0.40884721
116EEF2K0.40353562
117RPS6KA30.39911664
118MAP3K130.39862002
119ROCK10.38815257
120TYRO30.38067451
121SCYL20.37704866
122RPS6KB10.37605125
123CDC42BPA0.37229983
124PRKD10.33881134
125CSNK1G20.33718900
126MOS0.31258219
127STK38L0.29411292
128MAPK110.27142611
129RIPK10.26838364
130CSNK1G30.26640508
131PRKACG0.26244654
132BRAF0.25816629
133CSNK1G10.23526170
134DYRK1A0.23364996
135EPHA30.22740970

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.17369857
2Synaptic vesicle cycle_Homo sapiens_hsa047212.97257291
3Cardiac muscle contraction_Homo sapiens_hsa042602.72607520
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.60597770
5Oxidative phosphorylation_Homo sapiens_hsa001902.49564505
6GABAergic synapse_Homo sapiens_hsa047272.42450876
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38441040
8Circadian entrainment_Homo sapiens_hsa047132.28604791
9Parkinsons disease_Homo sapiens_hsa050122.21770533
10Olfactory transduction_Homo sapiens_hsa047402.20760726
11Morphine addiction_Homo sapiens_hsa050322.19576406
12Collecting duct acid secretion_Homo sapiens_hsa049662.04671820
13Long-term potentiation_Homo sapiens_hsa047202.04159009
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.97712733
15Glutamatergic synapse_Homo sapiens_hsa047241.97073988
16Alzheimers disease_Homo sapiens_hsa050101.93513383
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90773564
18Amphetamine addiction_Homo sapiens_hsa050311.89375961
19Dilated cardiomyopathy_Homo sapiens_hsa054141.87370799
20Insulin secretion_Homo sapiens_hsa049111.85188205
21Dopaminergic synapse_Homo sapiens_hsa047281.82455218
22Salivary secretion_Homo sapiens_hsa049701.71920497
23Gastric acid secretion_Homo sapiens_hsa049711.70153509
24Calcium signaling pathway_Homo sapiens_hsa040201.66385688
25Oxytocin signaling pathway_Homo sapiens_hsa049211.65471931
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.63803460
27Taste transduction_Homo sapiens_hsa047421.62515906
28Cholinergic synapse_Homo sapiens_hsa047251.58983544
29Serotonergic synapse_Homo sapiens_hsa047261.53750807
30Renin secretion_Homo sapiens_hsa049241.50289619
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49620039
32Arginine and proline metabolism_Homo sapiens_hsa003301.45174101
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39947436
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38102811
35Vibrio cholerae infection_Homo sapiens_hsa051101.36015026
36Long-term depression_Homo sapiens_hsa047301.33593406
37Huntingtons disease_Homo sapiens_hsa050161.26568601
38Cocaine addiction_Homo sapiens_hsa050301.25209208
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17834245
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13044879
41GnRH signaling pathway_Homo sapiens_hsa049121.12823891
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08963123
43cAMP signaling pathway_Homo sapiens_hsa040241.04311529
44Type II diabetes mellitus_Homo sapiens_hsa049301.04197986
45Gap junction_Homo sapiens_hsa045401.04061428
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02904735
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02095744
48Arginine biosynthesis_Homo sapiens_hsa002200.98641742
49Pentose phosphate pathway_Homo sapiens_hsa000300.98138800
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96197042
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94961217
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94010750
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.92780663
54Biosynthesis of amino acids_Homo sapiens_hsa012300.92193721
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89543080
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88093258
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86237625
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85647434
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84459516
60Phototransduction_Homo sapiens_hsa047440.83562521
61Glucagon signaling pathway_Homo sapiens_hsa049220.80394782
62Fructose and mannose metabolism_Homo sapiens_hsa000510.73465912
63Pancreatic secretion_Homo sapiens_hsa049720.72670492
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72206804
65Nitrogen metabolism_Homo sapiens_hsa009100.71411913
66Estrogen signaling pathway_Homo sapiens_hsa049150.71052650
67Insulin resistance_Homo sapiens_hsa049310.70902120
68Fatty acid metabolism_Homo sapiens_hsa012120.68794296
69Insulin signaling pathway_Homo sapiens_hsa049100.67626514
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67622517
71ErbB signaling pathway_Homo sapiens_hsa040120.65628707
72Fatty acid degradation_Homo sapiens_hsa000710.65403524
73Axon guidance_Homo sapiens_hsa043600.64774770
74Tight junction_Homo sapiens_hsa045300.63066807
75Glioma_Homo sapiens_hsa052140.61322506
76Type I diabetes mellitus_Homo sapiens_hsa049400.61007428
77Circadian rhythm_Homo sapiens_hsa047100.59919944
78MAPK signaling pathway_Homo sapiens_hsa040100.59281584
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55148086
80Melanogenesis_Homo sapiens_hsa049160.54446032
81Carbon metabolism_Homo sapiens_hsa012000.53648877
82Oocyte meiosis_Homo sapiens_hsa041140.52002131
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50831748
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49769364
85Butanoate metabolism_Homo sapiens_hsa006500.49282063
86Rheumatoid arthritis_Homo sapiens_hsa053230.48547624
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48434358
88Inositol phosphate metabolism_Homo sapiens_hsa005620.45943653
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.44555330
90Fatty acid elongation_Homo sapiens_hsa000620.44534516
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44110597
92VEGF signaling pathway_Homo sapiens_hsa043700.43585461
93Regulation of autophagy_Homo sapiens_hsa041400.43446490
94Pyruvate metabolism_Homo sapiens_hsa006200.43195286
95Phagosome_Homo sapiens_hsa041450.42832033
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.42633953
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42252343
98Dorso-ventral axis formation_Homo sapiens_hsa043200.41544985
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.41331800
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40466997
101Phenylalanine metabolism_Homo sapiens_hsa003600.38495970
102Renal cell carcinoma_Homo sapiens_hsa052110.38459794
103Propanoate metabolism_Homo sapiens_hsa006400.37966291
104Thyroid hormone synthesis_Homo sapiens_hsa049180.37858103
105Choline metabolism in cancer_Homo sapiens_hsa052310.37654893
106mTOR signaling pathway_Homo sapiens_hsa041500.36462296
107beta-Alanine metabolism_Homo sapiens_hsa004100.36387800
108Ras signaling pathway_Homo sapiens_hsa040140.36275753
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35418050
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34245655
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33415022
112Focal adhesion_Homo sapiens_hsa045100.33200556
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.33014626
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31628255
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29456482
116Endocytosis_Homo sapiens_hsa041440.29435593
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28382921
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27491889
119AMPK signaling pathway_Homo sapiens_hsa041520.26594454
120Purine metabolism_Homo sapiens_hsa002300.24838984
121Viral myocarditis_Homo sapiens_hsa054160.23414248

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