SLC25A13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.16029815
2L-phenylalanine catabolic process (GO:0006559)7.16029815
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.97531930
4L-phenylalanine metabolic process (GO:0006558)6.97531930
5aromatic amino acid family catabolic process (GO:0009074)6.51074838
6glyoxylate metabolic process (GO:0046487)6.06707263
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.01010720
8kynurenine metabolic process (GO:0070189)5.98458590
9tryptophan catabolic process (GO:0006569)5.91555613
10indole-containing compound catabolic process (GO:0042436)5.91555613
11indolalkylamine catabolic process (GO:0046218)5.91555613
12bile acid biosynthetic process (GO:0006699)5.70033364
13tryptophan metabolic process (GO:0006568)5.58874446
14urea cycle (GO:0000050)5.45247587
15urea metabolic process (GO:0019627)5.45247587
16alpha-linolenic acid metabolic process (GO:0036109)5.43559430
17serine family amino acid catabolic process (GO:0009071)5.37573358
18cysteine metabolic process (GO:0006534)5.33950850
19negative regulation of fibrinolysis (GO:0051918)5.33031621
20sulfur amino acid catabolic process (GO:0000098)5.25421564
21lysine metabolic process (GO:0006553)5.16967645
22lysine catabolic process (GO:0006554)5.16967645
23high-density lipoprotein particle remodeling (GO:0034375)5.14340959
24regulation of fibrinolysis (GO:0051917)5.04345434
25glycine metabolic process (GO:0006544)5.04046327
26peptidyl-glutamic acid carboxylation (GO:0017187)5.03273531
27protein carboxylation (GO:0018214)5.03273531
28nitrogen cycle metabolic process (GO:0071941)5.00822960
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.00709658
30regulation of protein activation cascade (GO:2000257)5.00420160
31homocysteine metabolic process (GO:0050667)4.95537246
32complement activation, alternative pathway (GO:0006957)4.94311346
33amino-acid betaine metabolic process (GO:0006577)4.89169107
34bile acid metabolic process (GO:0008206)4.84470989
35aromatic amino acid family metabolic process (GO:0009072)4.78648332
36alpha-amino acid catabolic process (GO:1901606)4.68611569
37regulation of complement activation (GO:0030449)4.66324519
38regulation of triglyceride catabolic process (GO:0010896)4.65964492
39serine family amino acid metabolic process (GO:0009069)4.58400775
40tyrosine metabolic process (GO:0006570)4.55279793
41regulation of cholesterol esterification (GO:0010872)4.51345978
42serine family amino acid biosynthetic process (GO:0009070)4.50163513
43cellular ketone body metabolic process (GO:0046950)4.46309258
44protein-lipid complex remodeling (GO:0034368)4.45540215
45macromolecular complex remodeling (GO:0034367)4.45540215
46plasma lipoprotein particle remodeling (GO:0034369)4.45540215
47reverse cholesterol transport (GO:0043691)4.44660459
48establishment of integrated proviral latency (GO:0075713)4.38970871
49triglyceride homeostasis (GO:0070328)4.38481100
50acylglycerol homeostasis (GO:0055090)4.38481100
51negative regulation of cholesterol transport (GO:0032375)4.36708891
52negative regulation of sterol transport (GO:0032372)4.36708891
53cellular amino acid catabolic process (GO:0009063)4.33366712
54imidazole-containing compound metabolic process (GO:0052803)4.33173397
55plasma lipoprotein particle clearance (GO:0034381)4.23431900
56ethanol oxidation (GO:0006069)4.22666459
57nuclear pore complex assembly (GO:0051292)4.22049396
58phospholipid efflux (GO:0033700)4.17892474
59cellular glucuronidation (GO:0052695)4.12992349
60indolalkylamine metabolic process (GO:0006586)4.12872750
61chromatin remodeling at centromere (GO:0031055)4.10854134
62coenzyme catabolic process (GO:0009109)4.10424191
63glutamate metabolic process (GO:0006536)4.10118199
64CENP-A containing nucleosome assembly (GO:0034080)4.08063809
65bile acid and bile salt transport (GO:0015721)4.05970308
66cellular modified amino acid catabolic process (GO:0042219)4.04824429
67dicarboxylic acid biosynthetic process (GO:0043650)4.03897594
68cellular biogenic amine catabolic process (GO:0042402)4.03731637
69amine catabolic process (GO:0009310)4.03731637
70aldehyde catabolic process (GO:0046185)4.02395596
71nuclear pore organization (GO:0006999)3.99712706
72benzene-containing compound metabolic process (GO:0042537)3.99487465
73aspartate family amino acid catabolic process (GO:0009068)3.95988292
74acetyl-CoA metabolic process (GO:0006084)3.91934336
752-oxoglutarate metabolic process (GO:0006103)3.91503843
76DNA unwinding involved in DNA replication (GO:0006268)3.90940180
77ketone body metabolic process (GO:1902224)3.90137824
78arginine metabolic process (GO:0006525)3.86923988
79cholesterol efflux (GO:0033344)3.85281488
80organic acid catabolic process (GO:0016054)3.84732547
81carboxylic acid catabolic process (GO:0046395)3.84732547
82short-chain fatty acid metabolic process (GO:0046459)3.82723524
83protein localization to kinetochore (GO:0034501)3.78727254
84plasma lipoprotein particle assembly (GO:0034377)3.77457732
85carnitine metabolic process (GO:0009437)3.76933419
86purine nucleobase biosynthetic process (GO:0009113)3.76403457
87drug catabolic process (GO:0042737)3.75717965
88phospholipid homeostasis (GO:0055091)3.74297198
89DNA strand elongation involved in DNA replication (GO:0006271)3.74255367
90fibrinolysis (GO:0042730)3.73296790
91fatty acid beta-oxidation (GO:0006635)3.72457780
92negative regulation of fatty acid biosynthetic process (GO:0045717)3.70242510
93blood coagulation, intrinsic pathway (GO:0007597)3.67649630
94cholesterol homeostasis (GO:0042632)3.67394247
95low-density lipoprotein particle remodeling (GO:0034374)3.65278954
96fatty acid oxidation (GO:0019395)3.64463933
97IMP biosynthetic process (GO:0006188)3.62645501
98uronic acid metabolic process (GO:0006063)3.62415485
99glucuronate metabolic process (GO:0019585)3.62415485
100DNA replication checkpoint (GO:0000076)3.62181569
101sterol homeostasis (GO:0055092)3.61939382
102DNA strand elongation (GO:0022616)3.60579817
103positive regulation of lipoprotein lipase activity (GO:0051006)3.60193293
104positive regulation of triglyceride lipase activity (GO:0061365)3.60193293
105monocarboxylic acid catabolic process (GO:0072329)3.59480529
106very-low-density lipoprotein particle assembly (GO:0034379)3.57263626
107cofactor catabolic process (GO:0051187)3.56547240
108lipid oxidation (GO:0034440)3.56369122
109mitotic metaphase plate congression (GO:0007080)3.54845448
110positive regulation of lipid catabolic process (GO:0050996)3.54488429
111regulation of bile acid biosynthetic process (GO:0070857)3.51926526
112DNA replication-independent nucleosome organization (GO:0034724)3.49937569
113DNA replication-independent nucleosome assembly (GO:0006336)3.49937569
114fatty acid catabolic process (GO:0009062)3.49821826
115L-serine metabolic process (GO:0006563)3.49671876
116nucleobase biosynthetic process (GO:0046112)3.44527141
117ribosome assembly (GO:0042255)3.38428906
118heterochromatin organization (GO:0070828)3.38159857
119protein localization to chromosome, centromeric region (GO:0071459)3.38154472
120histone exchange (GO:0043486)3.37217018
121IMP metabolic process (GO:0046040)3.32105087
122establishment of viral latency (GO:0019043)3.26845389
123non-recombinational repair (GO:0000726)3.23876973
124double-strand break repair via nonhomologous end joining (GO:0006303)3.23876973
125DNA replication-dependent nucleosome assembly (GO:0006335)3.20727114
126DNA replication-dependent nucleosome organization (GO:0034723)3.20727114
127pre-miRNA processing (GO:0031054)3.19958544
128telomere maintenance via semi-conservative replication (GO:0032201)3.19748368
129mitotic sister chromatid segregation (GO:0000070)3.18901381
130regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16151183
131pore complex assembly (GO:0046931)3.14421479
132metaphase plate congression (GO:0051310)3.13892604
133formation of translation preinitiation complex (GO:0001731)3.09850011
134sister chromatid segregation (GO:0000819)3.03853103
135paraxial mesoderm development (GO:0048339)3.02362647
136mitotic sister chromatid cohesion (GO:0007064)2.98773567
137DNA replication initiation (GO:0006270)2.97720494
138protein complex localization (GO:0031503)2.97643587
139mitotic nuclear envelope disassembly (GO:0007077)2.94311038
140tetrahydrofolate metabolic process (GO:0046653)2.85161430
141DNA ligation (GO:0006266)2.81159659
142mitotic chromosome condensation (GO:0007076)2.80059597
143regulation of helicase activity (GO:0051095)2.79615404
144proteasome assembly (GO:0043248)2.79424281
145spindle checkpoint (GO:0031577)2.79009131
146folic acid-containing compound biosynthetic process (GO:0009396)2.76941972
147regulation of chromosome segregation (GO:0051983)2.75740378
148negative regulation of chromosome segregation (GO:0051985)2.74949903
149telomere maintenance via recombination (GO:0000722)2.73194830
150mitotic recombination (GO:0006312)2.72753805
151ATP-dependent chromatin remodeling (GO:0043044)2.71320637
152regulation of translational fidelity (GO:0006450)2.70357856
153mitotic spindle checkpoint (GO:0071174)2.70149069
154negative regulation of mitotic sister chromatid separation (GO:2000816)2.70060547
155negative regulation of sister chromatid segregation (GO:0033046)2.70060547
156negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.70060547
157negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.70060547
158negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70060547
159spliceosomal snRNP assembly (GO:0000387)2.65480870
160membrane disassembly (GO:0030397)2.64504280
161nuclear envelope disassembly (GO:0051081)2.64504280
162chromatin assembly or disassembly (GO:0006333)2.64118325
163DNA strand renaturation (GO:0000733)2.63924089
164regulation of centriole replication (GO:0046599)2.63757718
165anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.63203498
166L-alpha-amino acid transmembrane transport (GO:1902475)2.62253469
167kinetochore organization (GO:0051383)2.61788168
168regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60521862
169tRNA aminoacylation for protein translation (GO:0006418)2.60254538
170regulation of mitochondrial translation (GO:0070129)2.59830012
171negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59115188
172pteridine-containing compound biosynthetic process (GO:0042559)2.59060448
173tRNA aminoacylation (GO:0043039)2.58689393
174amino acid activation (GO:0043038)2.58689393
175regulation of centrosome cycle (GO:0046605)2.57955869
176regulation of sister chromatid cohesion (GO:0007063)2.57814026
177regulation of mitotic metaphase/anaphase transition (GO:0030071)2.57464178
178regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.57464178
179positive regulation of chromosome segregation (GO:0051984)2.56305378
180cellular protein complex localization (GO:0034629)2.55046083
181DNA damage response, detection of DNA damage (GO:0042769)2.54272818
182somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50844491
183somatic hypermutation of immunoglobulin genes (GO:0016446)2.50844491
184mitotic spindle assembly checkpoint (GO:0007094)2.50349222
185establishment of chromosome localization (GO:0051303)2.49479055
186spindle assembly checkpoint (GO:0071173)2.46574749
187regulation of mitotic sister chromatid separation (GO:0010965)2.46341834
188regulation of mitotic sister chromatid segregation (GO:0033047)2.46341834
189regulation of sister chromatid segregation (GO:0033045)2.46341834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.54570053
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.63387660
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.37268527
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.74911654
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.01545708
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.85539075
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.62908144
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.91825148
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.70976822
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.55453426
11* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.45719923
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.69106476
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62141275
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.51171592
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.50882661
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.49875677
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44679476
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38055847
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29462483
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18863461
21* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.12528069
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.12256579
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.07050729
24ELK1_19687146_ChIP-ChIP_HELA_Human2.05753830
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02423662
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9655670
27* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.97699669
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91712033
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.89136222
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88203896
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87006749
32XRN2_22483619_ChIP-Seq_HELA_Human1.84909419
33DCP1A_22483619_ChIP-Seq_HELA_Human1.84274153
34TTF2_22483619_ChIP-Seq_HELA_Human1.83355738
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79721402
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.78568327
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72126290
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68928484
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61382876
40CLOCK_20551151_ChIP-Seq_293T_Human1.60190738
41FOXP3_21729870_ChIP-Seq_TREG_Human1.59842153
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57241198
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56993556
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56034487
45GABP_19822575_ChIP-Seq_HepG2_Human1.53795175
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52353211
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49980714
48NANOG_16153702_ChIP-ChIP_HESCs_Human1.49821007
49E2F7_22180533_ChIP-Seq_HELA_Human1.43664143
50GATA1_22025678_ChIP-Seq_K562_Human1.40885912
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39779474
52VDR_23849224_ChIP-Seq_CD4+_Human1.36700950
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34753579
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33314573
55* HNF4A_19822575_ChIP-Seq_HepG2_Human1.30990142
56* FOXA2_19822575_ChIP-Seq_HepG2_Human1.26925549
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25090160
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23356311
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.22601476
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22432720
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21733654
62* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21188808
63RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19473717
64AR_21909140_ChIP-Seq_LNCAP_Human1.19416578
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19003162
66MYC_18940864_ChIP-ChIP_HL60_Human1.16388006
67CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15587387
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14342173
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13915572
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13453935
71ZNF263_19887448_ChIP-Seq_K562_Human1.13379341
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11570738
73HTT_18923047_ChIP-ChIP_STHdh_Human1.10482456
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10013599
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09215050
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07787577
77* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06524746
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05630636
79KDM5A_27292631_Chip-Seq_BREAST_Human1.02854644
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.00517302
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00261498
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99839546
83ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98594966
84NANOG_21062744_ChIP-ChIP_HESCs_Human0.96274165
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95482648
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93060471
87MYC_18555785_ChIP-Seq_MESCs_Mouse0.91003533
88NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90809666
89SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90739714
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89668171
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89105938
92* TFEB_21752829_ChIP-Seq_HELA_Human0.88166514
93SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86995446
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85554308
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83310075
96TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83203884
97EWS_26573619_Chip-Seq_HEK293_Human0.82375230
98* GATA4_25053715_ChIP-Seq_YYC3_Human0.81760408
99RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80651210
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79262532
101CHD1_26751641_Chip-Seq_LNCaP_Human0.79089620
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79072249
103* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.79030889
104* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78356579
105* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78142978
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78142625
107* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75834474
108RARA_24833708_ChIP-Seq_LIVER_Mouse0.75663822
109* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74557592
110SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.74302151
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.74293543
112KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74083176
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73964199
114MYC_18358816_ChIP-ChIP_MESCs_Mouse0.72782183
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.71836102
116AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70115300
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.68325912
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.66540470
119RARB_24833708_ChIP-Seq_LIVER_Mouse0.65777539
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.64283735
121SRF_21415370_ChIP-Seq_HL-1_Mouse0.64190623
122FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.63904948
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.63415940
124GATA6_25053715_ChIP-Seq_YYC3_Human0.62029718
125IRF8_22096565_ChIP-ChIP_GC-B_Human0.60984472
126CREB1_15753290_ChIP-ChIP_HEK293T_Human0.60118258
127* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.59649925
128NELFA_20434984_ChIP-Seq_ESCs_Mouse0.59515170
129KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.58584854
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.57695208
131NANOG_18555785_ChIP-Seq_MESCs_Mouse0.57572806
132CEBPB_22108803_ChIP-Seq_LS180_Human0.57509639
133TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.57337770
134PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.56950492
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.56315367
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.55406723
137* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.53134281
138* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.52299160
139ZFX_18555785_ChIP-Seq_MESCs_Mouse0.50738982
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.50646397
141FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.50589673
142* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.50408736
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.50153327
144KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.50000891
145KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.50000891
146KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.50000891
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.48317059
148ESR1_21235772_ChIP-Seq_MCF-7_Human0.48293421
149POU5F1_16518401_ChIP-PET_MESCs_Mouse0.48230068
150POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.48029564
151* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.47877389
152AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.47463643
153POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.46528577
154ESET_19884257_ChIP-Seq_ESCs_Mouse0.46521091
155ESR2_21235772_ChIP-Seq_MCF-7_Human0.46031391
156SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.45455037
157ATF3_27146783_Chip-Seq_COLON_Human0.45017124
158* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.44314660
159SOX17_20123909_ChIP-Seq_XEN_Mouse0.44256859
160BRD4_27068464_Chip-Seq_AML-cells_Mouse0.43759997
161* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.43271076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.82704050
2MP0005360_urolithiasis7.29039965
3MP0005085_abnormal_gallbladder_physiolo6.24663777
4MP0005365_abnormal_bile_salt5.82364070
5MP0003806_abnormal_nucleotide_metabolis4.93938973
6MP0008875_abnormal_xenobiotic_pharmacok4.75836708
7MP0003693_abnormal_embryo_hatching3.73899218
8MP0003252_abnormal_bile_duct3.68856973
9MP0004957_abnormal_blastocyst_morpholog3.57945015
10MP0010094_abnormal_chromosome_stability3.36805274
11MP0009840_abnormal_foam_cell3.28764869
12MP0010329_abnormal_lipoprotein_level3.25683464
13MP0008057_abnormal_DNA_replication3.14138781
14MP0003111_abnormal_nucleus_morphology3.10969877
15MP0005083_abnormal_biliary_tract2.94796419
16MP0003941_abnormal_skin_development2.86587103
17MP0005332_abnormal_amino_acid2.80050138
18MP0003195_calcinosis2.66878992
19MP0008932_abnormal_embryonic_tissue2.65674146
20MP0008058_abnormal_DNA_repair2.57685712
21MP0003077_abnormal_cell_cycle2.52897965
22MP0003890_abnormal_embryonic-extraembry2.39859781
23MP0001666_abnormal_nutrient_absorption2.38768266
24MP0003191_abnormal_cellular_cholesterol2.16075149
25MP0004019_abnormal_vitamin_homeostasis2.09305823
26* MP0000609_abnormal_liver_physiology2.07471682
27MP0001730_embryonic_growth_arrest2.01003616
28MP0008007_abnormal_cellular_replicative1.97606005
29MP0002138_abnormal_hepatobiliary_system1.95191859
30MP0001293_anophthalmia1.92390539
31MP0005319_abnormal_enzyme/_coenzyme1.90417205
32* MP0002118_abnormal_lipid_homeostasis1.89633345
33MP0010030_abnormal_orbit_morphology1.87084199
34MP0003937_abnormal_limbs/digits/tail_de1.74391132
35MP0002938_white_spotting1.68680847
36MP0006292_abnormal_olfactory_placode1.67842550
37MP0003123_paternal_imprinting1.65546775
38MP0002697_abnormal_eye_size1.63902674
39MP0003868_abnormal_feces_composition1.62313284
40MP0003136_yellow_coat_color1.61651019
41MP0009697_abnormal_copulation1.61259841
42MP0003186_abnormal_redox_activity1.60283625
43MP0001672_abnormal_embryogenesis/_devel1.57856928
44MP0005380_embryogenesis_phenotype1.57856928
45MP0001697_abnormal_embryo_size1.55118318
46MP0000537_abnormal_urethra_morphology1.54120891
47MP0005451_abnormal_body_composition1.53267193
48MP0000350_abnormal_cell_proliferation1.47300411
49MP0002084_abnormal_developmental_patter1.47143382
50MP0003705_abnormal_hypodermis_morpholog1.46902100
51MP0010352_gastrointestinal_tract_polyps1.46833912
52MP0005584_abnormal_enzyme/coenzyme_acti1.45925078
53* MP0001764_abnormal_homeostasis1.43236403
54MP0003122_maternal_imprinting1.42510019
55MP0003984_embryonic_growth_retardation1.40069504
56MP0002085_abnormal_embryonic_tissue1.39963494
57MP0002088_abnormal_embryonic_growth/wei1.35887514
58MP0000598_abnormal_liver_morphology1.27618445
59* MP0009643_abnormal_urine_homeostasis1.27574720
60MP0005187_abnormal_penis_morphology1.26949698
61MP0003119_abnormal_digestive_system1.26300269
62MP0002080_prenatal_lethality1.24516562
63MP0010234_abnormal_vibrissa_follicle1.22462955
64MP0006036_abnormal_mitochondrial_physio1.21190732
65MP0003315_abnormal_perineum_morphology1.20516907
66MP0002233_abnormal_nose_morphology1.19311712
67MP0003011_delayed_dark_adaptation1.19165712
68MP0003656_abnormal_erythrocyte_physiolo1.18765374
69MP0004272_abnormal_basement_membrane1.16724575
70MP0001286_abnormal_eye_development1.13173076
71MP0000566_synostosis1.11501339
72MP0003121_genomic_imprinting1.10492932
73MP0002092_abnormal_eye_morphology1.08255456
74MP0009703_decreased_birth_body1.08144559
75MP0002086_abnormal_extraembryonic_tissu1.08038333
76MP0002111_abnormal_tail_morphology1.07726266
77MP0004197_abnormal_fetal_growth/weight/1.07044962
78MP0002254_reproductive_system_inflammat1.06883936
79MP0000647_abnormal_sebaceous_gland1.06267087
80MP0010307_abnormal_tumor_latency1.06041118
81MP0005647_abnormal_sex_gland1.05824448
82MP0009763_increased_sensitivity_to1.05523758
83MP0002090_abnormal_vision1.05254217
84MP0000372_irregular_coat_pigmentation1.05022073
85MP0002837_dystrophic_cardiac_calcinosis1.00939132
86MP0010368_abnormal_lymphatic_system0.97905728
87MP0008877_abnormal_DNA_methylation0.96732578
88MP0005266_abnormal_metabolism0.95706198
89MP0005408_hypopigmentation0.92122362
90MP0003786_premature_aging0.91650744
91MP0005670_abnormal_white_adipose0.88751853
92MP0005379_endocrine/exocrine_gland_phen0.85015909
93MP0006035_abnormal_mitochondrial_morpho0.84632890
94MP0009764_decreased_sensitivity_to0.83520151
95MP0005636_abnormal_mineral_homeostasis0.83516324
96MP0009053_abnormal_anal_canal0.82556128
97MP0008469_abnormal_protein_level0.82285604
98* MP0005376_homeostasis/metabolism_phenot0.81225262
99MP0008789_abnormal_olfactory_epithelium0.79871751
100MP0001324_abnormal_eye_pigmentation0.79673248
101MP0000313_abnormal_cell_death0.78613464
102* MP0009642_abnormal_blood_homeostasis0.78545594
103MP0004130_abnormal_muscle_cell0.78117896
104MP0005499_abnormal_olfactory_system0.77559559
105MP0005394_taste/olfaction_phenotype0.77559559
106MP0003718_maternal_effect0.76345857
107MP0005391_vision/eye_phenotype0.75793798
108MP0000428_abnormal_craniofacial_morphol0.75704138
109MP0006072_abnormal_retinal_apoptosis0.75431470
110MP0005197_abnormal_uvea_morphology0.75071000
111MP0004233_abnormal_muscle_weight0.74672250
112MP0000358_abnormal_cell_content/0.74448860
113MP0001529_abnormal_vocalization0.73977437
114MP0002751_abnormal_autonomic_nervous0.73808998
115MP0000604_amyloidosis0.72524138
116MP0009765_abnormal_xenobiotic_induced0.72223677
117MP0002210_abnormal_sex_determination0.69693238
118MP0005330_cardiomyopathy0.67799440
119MP0005257_abnormal_intraocular_pressure0.66985293
120MP0003943_abnormal_hepatobiliary_system0.66735133
121MP0003861_abnormal_nervous_system0.66594787
122MP0010678_abnormal_skin_adnexa0.66059497
123MP0001145_abnormal_male_reproductive0.65907981
124MP0001929_abnormal_gametogenesis0.65081453
125MP0003935_abnormal_craniofacial_develop0.64510639
126MP0000432_abnormal_head_morphology0.63872064
127MP0002163_abnormal_gland_morphology0.63837174
128* MP0002078_abnormal_glucose_homeostasis0.63760022
129MP0002971_abnormal_brown_adipose0.62694808
130MP0001756_abnormal_urination0.60936225
131MP0005666_abnormal_adipose_tissue0.59675085
132MP0005220_abnormal_exocrine_pancreas0.59637870
133MP0002269_muscular_atrophy0.58650868
134MP0005084_abnormal_gallbladder_morpholo0.58231235
135MP0001661_extended_life_span0.58023219
136MP0005395_other_phenotype0.56686068
137MP0005334_abnormal_fat_pad0.53648143
138MP0003646_muscle_fatigue0.53031952
139MP0002136_abnormal_kidney_physiology0.52821816
140MP0009672_abnormal_birth_weight0.47915226
141MP0008873_increased_physiological_sensi0.47555602
142MP0003221_abnormal_cardiomyocyte_apopto0.47449043
143MP0004084_abnormal_cardiac_muscle0.44262044
144MP0001853_heart_inflammation0.44241734
145MP0005023_abnormal_wound_healing0.43096593
146MP0000639_abnormal_adrenal_gland0.41923621
147MP0005464_abnormal_platelet_physiology0.39844258
148MP0002796_impaired_skin_barrier0.39624946
149MP0005535_abnormal_body_temperature0.38746329
150MP0004264_abnormal_extraembryonic_tissu0.38244021
151MP0004782_abnormal_surfactant_physiolog0.38069320
152MP0010630_abnormal_cardiac_muscle0.37375518
153MP0001544_abnormal_cardiovascular_syste0.37006664
154MP0005385_cardiovascular_system_phenoty0.37006664
155MP0003638_abnormal_response/metabolism_0.35608837
156MP0005248_abnormal_Harderian_gland0.34966438
157MP0001915_intracranial_hemorrhage0.34545932
158MP0003690_abnormal_glial_cell0.34537222
159MP0005448_abnormal_energy_balance0.33046288
160MP0002928_abnormal_bile_duct0.32776859
161MP0002970_abnormal_white_adipose0.32634299
162MP0008775_abnormal_heart_ventricle0.32412490
163MP0006138_congestive_heart_failure0.32114902
164MP0009115_abnormal_fat_cell0.29697805
165MP0002332_abnormal_exercise_endurance0.29393544
166MP0004036_abnormal_muscle_relaxation0.28656705
167MP0003453_abnormal_keratinocyte_physiol0.28371839
168MP0003436_decreased_susceptibility_to0.28310806
169MP0002876_abnormal_thyroid_physiology0.28295613
170MP0000579_abnormal_nail_morphology0.28288553
171MP0000249_abnormal_blood_vessel0.27745284
172MP0001243_abnormal_dermal_layer0.27355042
173MP0004185_abnormal_adipocyte_glucose0.27137895
174MP0000230_abnormal_systemic_arterial0.26331077
175MP0002135_abnormal_kidney_morphology0.26047429
176MP0003567_abnormal_fetal_cardiomyocyte0.25838646

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.88601304
2Deep venous thrombosis (HP:0002625)6.83510101
3* Intrahepatic cholestasis (HP:0001406)6.79768774
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.61035400
5Hypobetalipoproteinemia (HP:0003563)6.27977133
6Xanthomatosis (HP:0000991)6.06276437
7Prolonged partial thromboplastin time (HP:0003645)5.92892277
8Hyperlipoproteinemia (HP:0010980)5.13594562
9* Hyperammonemia (HP:0001987)4.80041715
10Complement deficiency (HP:0004431)4.77866657
11Hyperglycinemia (HP:0002154)4.66466361
12Hyperglycinuria (HP:0003108)4.44771978
13Ketosis (HP:0001946)4.44144949
14* Hypolipoproteinemia (HP:0010981)4.39115476
15Epidermoid cyst (HP:0200040)4.37818636
16Joint hemorrhage (HP:0005261)4.35602707
17Abnormality of serine family amino acid metabolism (HP:0010894)4.34232876
18Abnormality of glycine metabolism (HP:0010895)4.34232876
19Abnormality of pyrimidine metabolism (HP:0004353)4.28116169
20Hypoglycemic coma (HP:0001325)4.26167750
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.18078286
22Abnormality of the common coagulation pathway (HP:0010990)4.04437126
23* Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.01750274
24* Abnormality of sulfur amino acid metabolism (HP:0004339)3.99850137
25Fat malabsorption (HP:0002630)3.95955324
26* Abnormality of aspartate family amino acid metabolism (HP:0010899)3.91956162
27Abnormality of fatty-acid metabolism (HP:0004359)3.82400923
28* Abnormality of methionine metabolism (HP:0010901)3.82360865
29Abnormality of the intrinsic pathway (HP:0010989)3.57101144
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.55617854
31Abnormality of complement system (HP:0005339)3.53205956
32Chromosomal breakage induced by crosslinking agents (HP:0003221)3.43056672
33* Hypoalphalipoproteinemia (HP:0003233)3.42508720
34Abnormality of serum amino acid levels (HP:0003112)3.41270258
35Ketoacidosis (HP:0001993)3.33031329
36Chromsome breakage (HP:0040012)3.32909562
37Delayed CNS myelination (HP:0002188)3.24483595
38Abnormality of nucleobase metabolism (HP:0010932)3.24391249
39Conjugated hyperbilirubinemia (HP:0002908)3.16050374
40Dicarboxylic aciduria (HP:0003215)3.09528227
41Abnormality of dicarboxylic acid metabolism (HP:0010995)3.09528227
42Hypochromic microcytic anemia (HP:0004840)3.09137897
43Abnormality of glycolysis (HP:0004366)3.07226176
44Increased serum pyruvate (HP:0003542)3.03039714
45* Hyperbilirubinemia (HP:0002904)3.02363015
46* Hypercholesterolemia (HP:0003124)3.00237977
47Steatorrhea (HP:0002570)2.99741510
48Metabolic acidosis (HP:0001942)2.95378572
49Lethargy (HP:0001254)2.93223138
50Colon cancer (HP:0003003)2.82056117
51Spastic diplegia (HP:0001264)2.81447781
52Skin nodule (HP:0200036)2.80290242
53Cortical dysplasia (HP:0002539)2.76319748
54Nephroblastoma (Wilms tumor) (HP:0002667)2.72579062
55Abnormality of purine metabolism (HP:0004352)2.72528789
56Myocardial infarction (HP:0001658)2.68576631
57Spontaneous abortion (HP:0005268)2.64127349
58Gout (HP:0001997)2.62474107
59Embryonal renal neoplasm (HP:0011794)2.59604242
60* Cerebral edema (HP:0002181)2.58571588
61Meckel diverticulum (HP:0002245)2.57960561
62Abnormal lung lobation (HP:0002101)2.57355555
63* Hepatocellular carcinoma (HP:0001402)2.56049027
64Increased nuchal translucency (HP:0010880)2.50544668
65Pancreatic islet-cell hyperplasia (HP:0004510)2.48584263
66Vascular calcification (HP:0004934)2.47982730
67Generalized aminoaciduria (HP:0002909)2.45215544
68Cholelithiasis (HP:0001081)2.45187534
69Abnormal gallbladder morphology (HP:0012437)2.43512914
70Abnormality of the ileum (HP:0001549)2.41515160
71Hypoglycemic seizures (HP:0002173)2.38928679
72Reduced antithrombin III activity (HP:0001976)2.37387774
73Systemic lupus erythematosus (HP:0002725)2.36645878
74Malnutrition (HP:0004395)2.36559409
75Esophageal varix (HP:0002040)2.35636742
76Rhabdomyosarcoma (HP:0002859)2.33402355
77Multiple enchondromatosis (HP:0005701)2.32421312
78Acanthocytosis (HP:0001927)2.30070987
79Irritability (HP:0000737)2.29872058
80Hepatoblastoma (HP:0002884)2.29309155
81Vomiting (HP:0002013)2.29207963
82Abnormality of chromosome stability (HP:0003220)2.28391586
83Neonatal onset (HP:0003623)2.27223926
84Vaginal fistula (HP:0004320)2.22905827
85Acute encephalopathy (HP:0006846)2.21055719
86Proximal tubulopathy (HP:0000114)2.20813268
87Birth length less than 3rd percentile (HP:0003561)2.20468978
88Bifid tongue (HP:0010297)2.20216710
89Reticulocytopenia (HP:0001896)2.19056366
90Absent radius (HP:0003974)2.17882118
91Abnormal gallbladder physiology (HP:0012438)2.17329927
92Cholecystitis (HP:0001082)2.17329927
93Cardiovascular calcification (HP:0011915)2.17254018
94Nausea (HP:0002018)2.16766014
95Hyperinsulinemic hypoglycemia (HP:0000825)2.16208442
96Abnormality of the labia minora (HP:0012880)2.16124770
97Abnormal cartilage morphology (HP:0002763)2.14889825
98Late onset (HP:0003584)2.13858699
99Aplasia/Hypoplasia of the uvula (HP:0010293)2.08353514
100Abnormality of the preputium (HP:0100587)2.07496863
101Horseshoe kidney (HP:0000085)2.07247594
102Medulloblastoma (HP:0002885)2.06915631
103Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06563725
104Renal cortical cysts (HP:0000803)2.06408594
105Thrombophlebitis (HP:0004418)2.06285263
106Abnormality of the anterior horn cell (HP:0006802)2.05466995
107Degeneration of anterior horn cells (HP:0002398)2.05466995
108Glomerulonephritis (HP:0000099)2.05162948
109Volvulus (HP:0002580)2.05010616
110Recurrent gram-negative bacterial infections (HP:0005420)2.03632316
111Enlarged kidneys (HP:0000105)2.02917208
112Megaloblastic anemia (HP:0001889)1.98625522
113Poikilocytosis (HP:0004447)1.96681341
114Abnormality of iron homeostasis (HP:0011031)1.96547182
115Absent forearm bone (HP:0003953)1.96478428
116Aplasia involving forearm bones (HP:0009822)1.96478428
117Facial cleft (HP:0002006)1.95939726
118Abnormality of transition element cation homeostasis (HP:0011030)1.95907563
119Gingival bleeding (HP:0000225)1.95328882
120Sensorimotor neuropathy (HP:0007141)1.94490786
121Brushfield spots (HP:0001088)1.94233927
122Hydroxyprolinuria (HP:0003080)1.93823820
123Abnormality of proline metabolism (HP:0010907)1.93823820
124Rectal fistula (HP:0100590)1.93589673
125Rectovaginal fistula (HP:0000143)1.93589673
126Ependymoma (HP:0002888)1.93353929
127Glycosuria (HP:0003076)1.92519695
128Abnormality of urine glucose concentration (HP:0011016)1.92519695
129Symptomatic seizures (HP:0011145)1.92407287
130Opisthotonus (HP:0002179)1.92394932
131Abnormality of the duodenum (HP:0002246)1.91495802
132Abnormality of the gallbladder (HP:0005264)1.91452648
133Increased purine levels (HP:0004368)1.91386202
134Hyperuricemia (HP:0002149)1.91386202
135Myoglobinuria (HP:0002913)1.90205587
136Rickets (HP:0002748)1.87881880
137* Pancreatitis (HP:0001733)1.87821639
138Bifid scrotum (HP:0000048)1.86453678
139Menorrhagia (HP:0000132)1.85911745
140Abnormal enzyme/coenzyme activity (HP:0012379)1.85636288
141Mitral stenosis (HP:0001718)1.84124716
142Triphalangeal thumb (HP:0001199)1.83629664
143Type I transferrin isoform profile (HP:0003642)1.82955992
144Amyloidosis (HP:0011034)1.81193865
145Septo-optic dysplasia (HP:0100842)1.80024647
146Hyperglycemia (HP:0003074)1.79954638
147Proximal placement of thumb (HP:0009623)1.79543778
148Microvesicular hepatic steatosis (HP:0001414)1.78742565
149Increased hepatocellular lipid droplets (HP:0006565)1.74870762
150Duodenal stenosis (HP:0100867)1.73590948
151Small intestinal stenosis (HP:0012848)1.73590948
152Deviation of the thumb (HP:0009603)1.72461562
153Anal stenosis (HP:0002025)1.72039615
154Esophageal atresia (HP:0002032)1.71697514
155Intestinal atresia (HP:0011100)1.70140193
156Acute necrotizing encephalopathy (HP:0006965)1.64795619
157Overlapping toe (HP:0001845)1.64074753
158Anophthalmia (HP:0000528)1.63897904
159Gonadotropin excess (HP:0000837)1.63773884
160Homocystinuria (HP:0002156)1.63391398
161Abnormality of homocysteine metabolism (HP:0010919)1.63391398
162Stenosis of the external auditory canal (HP:0000402)1.62767139
163Lipid accumulation in hepatocytes (HP:0006561)1.62288007
164Hemivertebrae (HP:0002937)1.61461944
165Macrocytic anemia (HP:0001972)1.60919402
166Embryonal neoplasm (HP:0002898)1.59764108
167Ectopic kidney (HP:0000086)1.59151552
168Glioma (HP:0009733)1.56835792
169Abnormality of the pancreatic islet cells (HP:0006476)1.56280351
170Abnormality of endocrine pancreas physiology (HP:0012093)1.56280351
171Choanal atresia (HP:0000453)1.56187811
172Hyperalaninemia (HP:0003348)1.54466881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.20197247
2BUB13.58629798
3SRPK13.39278171
4FGFR43.36852446
5PKN23.35565114
6SIK13.26690497
7ERN13.12770814
8TSSK62.87891520
9FLT32.65148273
10ERBB42.61026859
11VRK22.48288958
12MKNK12.43233480
13TAF12.40778661
14PLK32.31580760
15PLK42.27164718
16NEK12.14958689
17EIF2AK32.08570824
18TRIM281.97257487
19MKNK21.95126407
20STK38L1.94410576
21TRIB31.83743018
22MST1R1.75450781
23LATS11.74275710
24TAOK31.72592509
25MAPK111.67577023
26MST41.66264914
27INSRR1.64284768
28MAP2K31.46693833
29PDK31.45786169
30PDK41.45786169
31MAP3K91.45375314
32WEE11.41413078
33KDR1.40471036
34NEK91.36679348
35STK161.36160237
36TYK21.32426200
37TNIK1.29145118
38ABL21.28848538
39MAP3K101.27630367
40BCR1.26623151
41CHEK21.26320070
42PAK41.25909623
43EPHA21.23644522
44BRSK11.23216588
45MAP3K31.22175162
46VRK11.20958980
47PTK61.20080801
48PINK11.19413863
49MET1.19023142
50EIF2AK11.17683594
51TIE11.16817164
52CDK41.15625006
53ATR1.15532713
54TTN1.15447278
55MAP2K41.11492812
56PIK3CG1.10695309
57TTK1.09539176
58MAP3K111.04497370
59CSNK1G11.03285527
60CDK60.99123145
61SMG10.97230317
62STK40.95632956
63EIF2AK20.93952597
64PRKAA20.93628860
65CHEK10.93541260
66NUAK10.92532107
67SCYL20.92090965
68PASK0.91910745
69PNCK0.90730039
70FGFR10.90599045
71DYRK30.90278324
72NME10.89417128
73ACVR1B0.88866147
74JAK20.86985106
75ATM0.86739869
76ALK0.85562704
77MAP3K70.83704919
78WNK30.83614882
79NME20.82597958
80PDK20.81910755
81CSNK1G30.79626380
82RIPK10.75806909
83BRD40.75336375
84TGFBR10.75008930
85BMPR1B0.74590555
86GRK60.71440567
87MAP3K50.71427984
88STK30.71117625
89MAP3K80.70086288
90ERBB20.69932925
91RPS6KA40.69374244
92AURKA0.69232313
93PBK0.68944748
94FRK0.68749323
95CSNK1E0.67175218
96MAPK40.66310936
97TBK10.65676238
98MTOR0.64844084
99PRKAA10.64506095
100CASK0.63981096
101OBSCN0.63219402
102CSNK1A1L0.63000224
103MYLK0.62978077
104CSNK1G20.62226802
105PLK20.61277840
106TGFBR20.61077028
107TAOK20.60815248
108RPS6KB20.60501346
109MAP3K140.59280573
110CDK10.58129833
111IRAK30.57374796
112GSK3A0.56858500
113STK100.55850761
114MAP2K60.55676014
115CDK20.53991511
116PRKACG0.53563716
117BRAF0.53198766
118FGFR20.52860243
119CDK70.50329057
120CSF1R0.49953030
121LATS20.49007302
122DYRK1B0.48623951
123AKT30.47815705
124ICK0.47209226
125ERBB30.45899667
126CDK120.44601143
127MAPK120.44183527
128PIM10.44133753
129FER0.43299056
130CSK0.43060528
131CAMK1G0.42291710
132CDC70.42154904
133PRKDC0.41154041
134PLK10.39620942
135BRSK20.39232149
136AURKB0.39003879
137AKT20.38222928
138CDK90.37633008
139JAK10.37365025
140YES10.36463426
141MAPKAPK30.36248778
142DAPK10.36123479
143DYRK20.36023515
144EPHB10.34958749
145MAP3K60.34643668
146MAPK70.34170280
147PRKCZ0.33801148
148CAMK1D0.32992959
149STK240.32319604
150CAMK2G0.32051349
151NEK20.31593179
152PIK3CA0.30872835
153LRRK20.30742005
154PTK20.30663484
155ZAK0.28660512
156CDK80.27843241
157CSNK2A20.26965519
158EGFR0.25632871
159CSNK2A10.25530531

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.14229098
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.53056506
3Nitrogen metabolism_Homo sapiens_hsa009103.34449940
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.21616880
5Arginine biosynthesis_Homo sapiens_hsa002202.95257358
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78481533
7Fatty acid degradation_Homo sapiens_hsa000712.64564519
8Tryptophan metabolism_Homo sapiens_hsa003802.61261209
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57490630
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54385026
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48631952
12Complement and coagulation cascades_Homo sapiens_hsa046102.45728433
13Non-homologous end-joining_Homo sapiens_hsa034502.23447889
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21159247
15Propanoate metabolism_Homo sapiens_hsa006402.16493737
16Butanoate metabolism_Homo sapiens_hsa006502.12789878
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.08882946
18Peroxisome_Homo sapiens_hsa041462.04689042
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95513567
20Fatty acid metabolism_Homo sapiens_hsa012121.88351084
21RNA transport_Homo sapiens_hsa030131.81644086
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.80714742
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78701991
24Chemical carcinogenesis_Homo sapiens_hsa052041.78604492
25Spliceosome_Homo sapiens_hsa030401.78540010
26PPAR signaling pathway_Homo sapiens_hsa033201.77102417
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76959521
28Selenocompound metabolism_Homo sapiens_hsa004501.73497999
29Histidine metabolism_Homo sapiens_hsa003401.73280727
30beta-Alanine metabolism_Homo sapiens_hsa004101.72255801
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.69934564
32Protein export_Homo sapiens_hsa030601.69744002
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68689748
34Cell cycle_Homo sapiens_hsa041101.60913946
35Homologous recombination_Homo sapiens_hsa034401.59663024
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59503538
37Retinol metabolism_Homo sapiens_hsa008301.53875199
38Phenylalanine metabolism_Homo sapiens_hsa003601.52554782
39Caffeine metabolism_Homo sapiens_hsa002321.51769861
40RNA polymerase_Homo sapiens_hsa030201.50802699
41Biosynthesis of amino acids_Homo sapiens_hsa012301.50800395
42Pyruvate metabolism_Homo sapiens_hsa006201.50586209
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50305275
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.49362234
45Carbon metabolism_Homo sapiens_hsa012001.48691345
46Staphylococcus aureus infection_Homo sapiens_hsa051501.48355244
47Nucleotide excision repair_Homo sapiens_hsa034201.44884297
48Ribosome_Homo sapiens_hsa030101.43052767
49Tyrosine metabolism_Homo sapiens_hsa003501.36721126
50One carbon pool by folate_Homo sapiens_hsa006701.32437350
51Folate biosynthesis_Homo sapiens_hsa007901.32076412
52Fatty acid elongation_Homo sapiens_hsa000621.31400982
53Starch and sucrose metabolism_Homo sapiens_hsa005001.29993863
54Bile secretion_Homo sapiens_hsa049761.29155520
55Fanconi anemia pathway_Homo sapiens_hsa034601.25248464
56Basal transcription factors_Homo sapiens_hsa030221.21893300
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.18486837
58Sulfur metabolism_Homo sapiens_hsa009201.14611862
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13649851
60Fat digestion and absorption_Homo sapiens_hsa049751.10307078
61Arginine and proline metabolism_Homo sapiens_hsa003301.10050527
62ABC transporters_Homo sapiens_hsa020101.03632487
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02038770
64RNA degradation_Homo sapiens_hsa030181.01289509
65Steroid biosynthesis_Homo sapiens_hsa001000.99915342
66Sulfur relay system_Homo sapiens_hsa041220.98194676
67mRNA surveillance pathway_Homo sapiens_hsa030150.95797776
68Lysine degradation_Homo sapiens_hsa003100.93709108
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93107401
70Vitamin B6 metabolism_Homo sapiens_hsa007500.92405973
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90803856
72Vitamin digestion and absorption_Homo sapiens_hsa049770.85299991
73Glutathione metabolism_Homo sapiens_hsa004800.82331287
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.76327322
75Pentose phosphate pathway_Homo sapiens_hsa000300.74608330
76Huntingtons disease_Homo sapiens_hsa050160.73219304
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72794959
78Purine metabolism_Homo sapiens_hsa002300.71719428
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65354960
80Thyroid cancer_Homo sapiens_hsa052160.63348438
81Glycerolipid metabolism_Homo sapiens_hsa005610.57172999
82N-Glycan biosynthesis_Homo sapiens_hsa005100.55003067
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54773918
84Oocyte meiosis_Homo sapiens_hsa041140.54387881
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52917505
86Metabolic pathways_Homo sapiens_hsa011000.52544466
87Adherens junction_Homo sapiens_hsa045200.47177138
88Fatty acid biosynthesis_Homo sapiens_hsa000610.46252320
89p53 signaling pathway_Homo sapiens_hsa041150.45198209
90TGF-beta signaling pathway_Homo sapiens_hsa043500.42200316
91Fructose and mannose metabolism_Homo sapiens_hsa000510.41239733
92Galactose metabolism_Homo sapiens_hsa000520.40782472
93Basal cell carcinoma_Homo sapiens_hsa052170.36500776
94Alzheimers disease_Homo sapiens_hsa050100.34325789
95Hippo signaling pathway_Homo sapiens_hsa043900.33682485
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24396759
97Insulin resistance_Homo sapiens_hsa049310.21526800
98Linoleic acid metabolism_Homo sapiens_hsa005910.20880807
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.18159293
100Prion diseases_Homo sapiens_hsa050200.17819504
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16845291
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.14023018
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13084939
104Systemic lupus erythematosus_Homo sapiens_hsa053220.09285670
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08365159
106Pyrimidine metabolism_Homo sapiens_hsa002400.07914315
107Glucagon signaling pathway_Homo sapiens_hsa049220.06473409
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.03582825
109AMPK signaling pathway_Homo sapiens_hsa041520.03228474
110Base excision repair_Homo sapiens_hsa03410-0.2211589
111Oxidative phosphorylation_Homo sapiens_hsa00190-0.2169755
112Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008-0.2098221
113Bladder cancer_Homo sapiens_hsa05219-0.1968934
114Parkinsons disease_Homo sapiens_hsa05012-0.1934388
115Regulation of autophagy_Homo sapiens_hsa04140-0.1911929
116Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1904455
117Proteasome_Homo sapiens_hsa03050-0.1882828
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1831614
119Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1648594
120Renin-angiotensin system_Homo sapiens_hsa04614-0.1407864
121Insulin signaling pathway_Homo sapiens_hsa04910-0.1223913
122Mismatch repair_Homo sapiens_hsa03430-0.1005241
123Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0912577
124Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0677976
125DNA replication_Homo sapiens_hsa03030-0.0614722

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