ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	embryonic viscerocranium morphogenesis (GO:0048703)	9.25908124
2	segment specification (GO:0007379)	7.49950678
3	response to nitrosative stress (GO:0051409)	7.35952666
4	neural tube formation (GO:0001841)	6.52320227
5	response to xenobiotic stimulus (GO:0009410)	6.44940243
6	fusion of sperm to egg plasma membrane (GO:0007342)	6.11493650
7	regulation of acrosome reaction (GO:0060046)	6.03325407
8	G-protein coupled receptor internalization (GO:0002031)	5.77354670
9	cysteine metabolic process (GO:0006534)	5.41983746
10	cell wall macromolecule catabolic process (GO:0016998)	5.36147598
11	osteoblast development (GO:0002076)	5.35834828
12	regulation of Golgi to plasma membrane protein transport (GO:0042996)	5.00365785
13	regulation of platelet aggregation (GO:0090330)	4.70923989
14	plasma membrane fusion (GO:0045026)	4.65558317
15	regulation of phospholipid biosynthetic process (GO:0071071)	4.48707684
16	pyrimidine dimer repair (GO:0006290)	4.47761126
17	fibroblast migration (GO:0010761)	4.44195131
18	cell wall macromolecule metabolic process (GO:0044036)	4.42691032
19	motor neuron axon guidance (GO:0008045)	4.41680489
20	C4-dicarboxylate transport (GO:0015740)	4.39639561
21	middle ear morphogenesis (GO:0042474)	4.36710629
22	mannosylation (GO:0097502)	4.33480800
23	lateral ventricle development (GO:0021670)	4.12922429
24	forebrain morphogenesis (GO:0048853)	4.00078661
25	L-ascorbic acid metabolic process (GO:0019852)	3.99232501
26	positive regulation of T cell cytokine production (GO:0002726)	3.97595972
27	cornea development in camera-type eye (GO:0061303)	3.97063080
28	central nervous system projection neuron axonogenesis (GO:0021952)	3.95485793
29	establishment of protein localization to Golgi (GO:0072600)	3.79369322
30	protein targeting to Golgi (GO:0000042)	3.77552918
31	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.76723155
32	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.71891392
33	protein kinase C signaling (GO:0070528)	3.63906226
34	tryptophan catabolic process (GO:0006569)	3.57131362
35	indole-containing compound catabolic process (GO:0042436)	3.57131362
36	indolalkylamine catabolic process (GO:0046218)	3.57131362
37	positive regulation of guanylate cyclase activity (GO:0031284)	3.51945200
38	rhodopsin mediated signaling pathway (GO:0016056)	3.50678457
39	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.50008872
40	serotonin receptor signaling pathway (GO:0007210)	3.49155192
41	central nervous system neuron axonogenesis (GO:0021955)	3.41024668
42	protein K11-linked deubiquitination (GO:0035871)	3.37095153
43	regulation of mRNA 3-end processing (GO:0031440)	3.36374768
44	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.36040511
45	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.35546163
46	GMP metabolic process (GO:0046037)	3.32972748
47	positive regulation of interleukin-17 production (GO:0032740)	3.28129866
48	benzene-containing compound metabolic process (GO:0042537)	3.23233864
49	phasic smooth muscle contraction (GO:0014821)	3.17748104
50	negative regulation of cell aging (GO:0090344)	3.15819339
51	aldehyde catabolic process (GO:0046185)	3.15322143
52	regulation of mitochondrial depolarization (GO:0051900)	3.14024280
53	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.13366326
54	spermatid nucleus differentiation (GO:0007289)	3.12289136
55	regulation of guanylate cyclase activity (GO:0031282)	3.11604183
56	hematopoietic stem cell differentiation (GO:0060218)	3.11193764
57	cerebral cortex cell migration (GO:0021795)	3.09112080
58	myelin assembly (GO:0032288)	3.08832593
59	diterpenoid biosynthetic process (GO:0016102)	3.07868754
60	embryonic epithelial tube formation (GO:0001838)	3.04940908
61	regulation of MHC class II biosynthetic process (GO:0045346)	3.02705968
62	cerebral cortex radially oriented cell migration (GO:0021799)	3.00498569
63	negative regulation of B cell proliferation (GO:0030889)	2.98174186
64	polyol transport (GO:0015791)	2.97911558
65	photoreceptor cell maintenance (GO:0045494)	2.93337033
66	organelle disassembly (GO:1903008)	2.91986613
67	retinal ganglion cell axon guidance (GO:0031290)	2.91979519
68	glycoprotein catabolic process (GO:0006516)	2.89664279
69	head development (GO:0060322)	2.89546734
70	inner ear receptor stereocilium organization (GO:0060122)	2.88397885
71	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.88177409
72	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.87161776
73	epithelial tube formation (GO:0072175)	2.85494337
74	positive regulation of mRNA processing (GO:0050685)	2.84792152
75	olfactory bulb development (GO:0021772)	2.78407440
76	interkinetic nuclear migration (GO:0022027)	2.77571409
77	mitotic sister chromatid cohesion (GO:0007064)	2.77164744
78	RNA polyadenylation (GO:0043631)	2.74529085
79	positive regulation of mRNA 3-end processing (GO:0031442)	2.74445400
80	segmentation (GO:0035282)	2.72860895
81	positive regulation of vasculogenesis (GO:2001214)	2.72480771
82	negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)	2.72342446
83	regulation of erythrocyte differentiation (GO:0045646)	2.69639555
84	negative regulation of autophagy (GO:0010507)	2.69611867
85	positive regulation of cell size (GO:0045793)	2.69333239
86	spinal cord association neuron differentiation (GO:0021527)	2.68858333
87	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.64851933
88	regulation of collateral sprouting (GO:0048670)	2.64749851
89	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.63983441
90	phospholipid translocation (GO:0045332)	2.62811292
91	lipid translocation (GO:0034204)	2.62811292
92	negative regulation of cardiac muscle tissue development (GO:0055026)	2.61874421
93	kynurenine metabolic process (GO:0070189)	2.57089365
94	galactose metabolic process (GO:0006012)	2.56844260
95	positive regulation of interleukin-4 production (GO:0032753)	2.54926476
96	nucleotide-sugar metabolic process (GO:0009225)	2.54191311
97	prenylation (GO:0097354)	2.52740825
98	protein prenylation (GO:0018342)	2.52740825
99	negative regulation of dendrite development (GO:2000171)	2.51617221
100	protein localization to Golgi apparatus (GO:0034067)	2.49626907

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.49493911
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.92469414
3	VDR_22108803_ChIP-Seq_LS180_Human	3.83915996
4	IRF1_19129219_ChIP-ChIP_H3396_Human	3.14484922
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.99025552
6	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.67062085
7	P300_19829295_ChIP-Seq_ESCs_Human	2.44594951
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40331928
9	EWS_26573619_Chip-Seq_HEK293_Human	2.35355294
10	ER_23166858_ChIP-Seq_MCF-7_Human	2.32972029
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.29790201
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.27593478
13	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.14068089
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.10891857
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01140821
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.93741137
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.88088536
18	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.83966631
19	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.83751899
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.81202939
21	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.80442206
22	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.80442206
23	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.80388786
24	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.76839532
25	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.72322543
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.72050816
27	RUNX2_22187159_ChIP-Seq_PCA_Human	1.68862055
28	TCF4_23295773_ChIP-Seq_U87_Human	1.68405705
29	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.64704045
30	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.64656123
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.62601907
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.62386833
33	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.59359485
34	FUS_26573619_Chip-Seq_HEK293_Human	1.59332602
35	STAT3_23295773_ChIP-Seq_U87_Human	1.59192552
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59111860
37	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.56932698
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.56112006
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.53740911
40	EGR1_19032775_ChIP-ChIP_M12_Human	1.52931003
41	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.51275124
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.51260160
43	SCL_19346495_ChIP-Seq_HPC-7_Human	1.49035038
44	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.48315493
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.48033199
46	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.45801387
47	GBX2_23144817_ChIP-Seq_PC3_Human	1.44843303
48	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.44828616
49	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.44203822
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42544492
51	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41666713
52	CDX2_22108803_ChIP-Seq_LS180_Human	1.38354975
53	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.30524769
54	MYC_18940864_ChIP-ChIP_HL60_Human	1.30137946
55	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.29036728
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28734083
57	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.28633451
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28463030
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27868286
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27868286
61	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.27737166
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26843170
63	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.26606736
64	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.26333494
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.23392215
66	HTT_18923047_ChIP-ChIP_STHdh_Human	1.23257152
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22941176
68	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.21971606
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.20934217
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20573560
71	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.20013848
72	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19408843
73	CBP_20019798_ChIP-Seq_JUKART_Human	1.19408843
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17364150
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16821673
76	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.14989134
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14449980
78	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.12926595
79	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12793206
80	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12793206
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12442763
82	TP53_16413492_ChIP-PET_HCT116_Human	1.12030610
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.11674730
84	TP53_18474530_ChIP-ChIP_U2OS_Human	1.10638280
85	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10106023
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09388780
87	VDR_24787735_ChIP-Seq_THP-1_Human	1.08718902
88	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07183561
89	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.06829620
90	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.05977245
91	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05914145
92	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.05197211
93	GATA3_26560356_Chip-Seq_TH2_Human	1.05059479
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04536897
95	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.03813792
96	AR_25329375_ChIP-Seq_VCAP_Human	1.03581213
97	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.03078844
98	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.02741938
99	AHR_22903824_ChIP-Seq_MCF-7_Human	1.02702482
100	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.02023772

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	4.48285162
2	MP0003890_abnormal_embryonic-extraembry	4.37146780
3	MP0005377_hearing/vestibular/ear_phenot	3.57137379
4	MP0003878_abnormal_ear_physiology	3.57137379
5	MP0001348_abnormal_lacrimal_gland	3.32411765
6	MP0005379_endocrine/exocrine_gland_phen	2.92888815
7	MP0006054_spinal_hemorrhage	2.61215019
8	MP0002234_abnormal_pharynx_morphology	2.54824893
9	MP0002837_dystrophic_cardiac_calcinosis	2.45130179
10	MP0003828_pulmonary_edema	2.19436679
11	MP0002928_abnormal_bile_duct	2.18442299
12	MP0002102_abnormal_ear_morphology	10.9831454
13	MP0003303_peritoneal_inflammation	1.96426795
14	MP0000049_abnormal_middle_ear	1.89866541
15	MP0002177_abnormal_outer_ear	1.83264514
16	MP0008789_abnormal_olfactory_epithelium	1.77439321
17	MP0000383_abnormal_hair_follicle	1.76270798
18	MP0003632_abnormal_nervous_system	1.68338671
19	MP0001661_extended_life_span	1.62309692
20	MP0002127_abnormal_cardiovascular_syste	1.52852029
21	MP0008569_lethality_at_weaning	1.52804605
22	MP0004147_increased_porphyrin_level	1.50637418
23	MP0004134_abnormal_chest_morphology	1.45980031
24	MP0003252_abnormal_bile_duct	1.41620806
25	MP0008775_abnormal_heart_ventricle	1.40122644
26	MP0002254_reproductive_system_inflammat	1.40108296
27	MP0001270_distended_abdomen	1.40058786
28	MP0001486_abnormal_startle_reflex	1.39819322
29	MP0005394_taste/olfaction_phenotype	1.37601204
30	MP0005499_abnormal_olfactory_system	1.37601204
31	MP0005551_abnormal_eye_electrophysiolog	1.35823921
32	MP0004215_abnormal_myocardial_fiber	1.23591485
33	MP0000015_abnormal_ear_pigmentation	1.22505596
34	MP0005253_abnormal_eye_physiology	1.20403207
35	MP0006138_congestive_heart_failure	1.19075809
36	MP0005167_abnormal_blood-brain_barrier	1.17764510
37	MP0001293_anophthalmia	1.15319781
38	MP0000762_abnormal_tongue_morphology	1.14527879
39	MP0006292_abnormal_olfactory_placode	1.11462118
40	MP0010678_abnormal_skin_adnexa	1.04342079
41	MP0003567_abnormal_fetal_cardiomyocyte	1.02386425
42	MP0000428_abnormal_craniofacial_morphol	1.00925859
43	MP0004185_abnormal_adipocyte_glucose	1.00513920
44	MP0004130_abnormal_muscle_cell	1.00257771
45	MP0005386_behavior/neurological_phenoty	1.00211265
46	MP0004924_abnormal_behavior	1.00211265
47	MP0000778_abnormal_nervous_system	0.99552407
48	MP0000026_abnormal_inner_ear	0.98284024
49	MP0000569_abnormal_digit_pigmentation	0.97329391
50	MP0003935_abnormal_craniofacial_develop	0.93981051
51	MP0002736_abnormal_nociception_after	0.90147115
52	MP0003195_calcinosis	0.89652091
53	MP0001324_abnormal_eye_pigmentation	0.89424148
54	MP0002090_abnormal_vision	0.87458566
55	MP0001915_intracranial_hemorrhage	0.87415796
56	MP0005508_abnormal_skeleton_morphology	0.86952050
57	MP0003385_abnormal_body_wall	0.85539091
58	MP0001919_abnormal_reproductive_system	0.85516331
59	MP0008004_abnormal_stomach_pH	0.85160019
60	MP0004133_heterotaxia	0.83554753
61	MP0008875_abnormal_xenobiotic_pharmacok	0.82612553
62	MP0002752_abnormal_somatic_nervous	0.82038726
63	MP0005646_abnormal_pituitary_gland	0.80346430
64	MP0005365_abnormal_bile_salt	0.80277278
65	MP0005391_vision/eye_phenotype	0.79813145
66	MP0002132_abnormal_respiratory_system	0.79557220
67	MP0003300_gastrointestinal_ulcer	0.79518250
68	MP0000427_abnormal_hair_cycle	0.79062560
69	MP0005666_abnormal_adipose_tissue	0.76213236
70	MP0006276_abnormal_autonomic_nervous	0.75883040
71	MP0004742_abnormal_vestibular_system	0.74230924
72	MP0004084_abnormal_cardiac_muscle	0.73419885
73	MP0005670_abnormal_white_adipose	0.69779389
74	MP0003755_abnormal_palate_morphology	0.69695147
75	MP0000372_irregular_coat_pigmentation	0.67853808
76	MP0002233_abnormal_nose_morphology	0.67347143
77	MP0000631_abnormal_neuroendocrine_gland	0.66987665
78	MP0003631_nervous_system_phenotype	0.65037928
79	MP0002282_abnormal_trachea_morphology	0.62532486
80	MP0001984_abnormal_olfaction	0.61871413
81	MP0001485_abnormal_pinna_reflex	0.60810076
82	MP0002751_abnormal_autonomic_nervous	0.59430945
83	MP0005195_abnormal_posterior_eye	0.59311863
84	MP0010352_gastrointestinal_tract_polyps	0.58817021
85	MP0005257_abnormal_intraocular_pressure	0.58767262
86	MP0001545_abnormal_hematopoietic_system	0.58154842
87	MP0005397_hematopoietic_system_phenotyp	0.58154842
88	MP0001286_abnormal_eye_development	0.57713852
89	MP0000613_abnormal_salivary_gland	0.57217339
90	MP0003950_abnormal_plasma_membrane	0.53694653
91	MP0002638_abnormal_pupillary_reflex	0.53538075
92	MP0002184_abnormal_innervation	0.52199706
93	MP0002095_abnormal_skin_pigmentation	0.48798815
94	MP0006072_abnormal_retinal_apoptosis	0.48417422
95	MP0010234_abnormal_vibrissa_follicle	0.48106097
96	MP0003045_fibrosis	0.47156799
97	MP0002882_abnormal_neuron_morphology	0.46790348
98	MP0000678_abnormal_parathyroid_gland	0.46241451
99	MP0005389_reproductive_system_phenotype	0.45490316
100	MP0005647_abnormal_sex_gland	0.45120441

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Mixed hearing impairment (HP:0000410)	6.42650056
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.76573379
3	Atonic seizures (HP:0010819)	4.55181673
4	Attenuation of retinal blood vessels (HP:0007843)	4.39568754
5	Increased hepatocellular lipid droplets (HP:0006565)	4.34001850
6	Abnormality of the parathyroid morphology (HP:0011766)	4.33685613
7	Lipid accumulation in hepatocytes (HP:0006561)	4.00508504
8	Microtia (HP:0008551)	3.60118172
9	Papillary thyroid carcinoma (HP:0002895)	3.57539894
10	Nephronophthisis (HP:0000090)	3.54330897
11	Febrile seizures (HP:0002373)	3.53510834
12	Popliteal pterygium (HP:0009756)	3.47129608
13	Abnormal rod and cone electroretinograms (HP:0008323)	3.20215041
14	Type I transferrin isoform profile (HP:0003642)	3.20017276
15	Abnormal protein glycosylation (HP:0012346)	3.07660822
16	Abnormal glycosylation (HP:0012345)	3.07660822
17	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.07660822
18	Abnormal protein N-linked glycosylation (HP:0012347)	3.07660822
19	Abnormality of midbrain morphology (HP:0002418)	3.07418632
20	Molar tooth sign on MRI (HP:0002419)	3.07418632
21	Distal arthrogryposis (HP:0005684)	3.03684008
22	Tented upper lip vermilion (HP:0010804)	2.99778017
23	Cutaneous melanoma (HP:0012056)	2.96806737
24	Poikiloderma (HP:0001029)	2.94335422
25	Pancreatic cysts (HP:0001737)	2.87476337
26	True hermaphroditism (HP:0010459)	2.77582639
27	Chronic hepatic failure (HP:0100626)	2.77149723
28	Abnormality of the renal medulla (HP:0100957)	2.70361255
29	Thyroid carcinoma (HP:0002890)	2.58584738
30	Abnormality of renal resorption (HP:0011038)	2.58123397
31	Pancreatic fibrosis (HP:0100732)	2.57989890
32	Congenital hepatic fibrosis (HP:0002612)	2.50053807
33	Renal Fanconi syndrome (HP:0001994)	2.48500644
34	Stenosis of the external auditory canal (HP:0000402)	2.42795661
35	Abnormality of the nasal septum (HP:0000419)	2.42304680
36	Entropion (HP:0000621)	2.42046061
37	Increased corneal curvature (HP:0100692)	2.38830934
38	Keratoconus (HP:0000563)	2.38830934
39	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.37100910
40	Abnormal auditory evoked potentials (HP:0006958)	2.31413043
41	Renal cortical cysts (HP:0000803)	2.30105977
42	Amyotrophic lateral sclerosis (HP:0007354)	2.25833599
43	Intellectual disability, moderate (HP:0002342)	2.24431876
44	Poor eye contact (HP:0000817)	2.20548052
45	Short tibia (HP:0005736)	2.17937676
46	Bulbous nose (HP:0000414)	2.17148576
47	Rectal fistula (HP:0100590)	2.16501361
48	Rectovaginal fistula (HP:0000143)	2.16501361
49	Curly hair (HP:0002212)	2.15892074
50	Exertional dyspnea (HP:0002875)	2.15890182
51	Hypochromic microcytic anemia (HP:0004840)	2.14366425
52	Asymmetric septal hypertrophy (HP:0001670)	2.09656265
53	Hip dysplasia (HP:0001385)	2.09512190
54	Pulmonary artery stenosis (HP:0004415)	2.08194091
55	Cupped ear (HP:0000378)	2.07549098
56	Medial flaring of the eyebrow (HP:0010747)	2.07412420
57	Thyroiditis (HP:0100646)	2.05936896
58	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.02637053
59	Abnormality of the renal cortex (HP:0011035)	2.00433005
60	Intrahepatic cholestasis (HP:0001406)	1.99358307
61	Ileus (HP:0002595)	1.99208683
62	Nuclear cataract (HP:0100018)	1.98554317
63	Constricted visual fields (HP:0001133)	1.96052123
64	Metaphyseal dysplasia (HP:0100255)	1.92548596
65	Neoplasm of the adrenal cortex (HP:0100641)	1.91281867
66	Glycosuria (HP:0003076)	1.90655908
67	Abnormality of urine glucose concentration (HP:0011016)	1.90655908
68	Portal hypertension (HP:0001409)	1.90229998
69	Cystic liver disease (HP:0006706)	1.88783612
70	Decreased central vision (HP:0007663)	1.88349785
71	Rectal prolapse (HP:0002035)	1.88077701
72	Cerebellar dysplasia (HP:0007033)	1.85874130
73	Depressed nasal tip (HP:0000437)	1.85477243
74	Morphological abnormality of the middle ear (HP:0008609)	1.84584603
75	Abolished electroretinogram (ERG) (HP:0000550)	1.84420204
76	Dyskinesia (HP:0100660)	1.83669593
77	Bony spicule pigmentary retinopathy (HP:0007737)	1.81177686
78	Midline defect of the nose (HP:0004122)	1.80282360
79	Nausea (HP:0002018)	1.80054100
80	Hyperglycinemia (HP:0002154)	1.79578469
81	Barrel-shaped chest (HP:0001552)	1.79485782
82	Congenital primary aphakia (HP:0007707)	1.78920999
83	Pendular nystagmus (HP:0012043)	1.76549394
84	Vaginal fistula (HP:0004320)	1.73817438
85	Hypothermia (HP:0002045)	1.73722630
86	Impaired social interactions (HP:0000735)	1.73608786
87	Abnormal social behavior (HP:0012433)	1.73608786
88	Broad palm (HP:0001169)	1.73202837
89	Widely spaced teeth (HP:0000687)	1.72730861
90	Action tremor (HP:0002345)	1.72382612
91	Ulnar claw (HP:0001178)	1.72080285
92	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.71619574
93	Decreased circulating renin level (HP:0003351)	1.71496467
94	Microcytic anemia (HP:0001935)	1.70918766
95	Reduced antithrombin III activity (HP:0001976)	1.70085123
96	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.69961511
97	Gait imbalance (HP:0002141)	1.69910517
98	Abnormality of the hepatic vasculature (HP:0006707)	1.69479239
99	Severe muscular hypotonia (HP:0006829)	1.69414789
100	Congenital stationary night blindness (HP:0007642)	1.68680499

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	6.32773531
2	BRD4	5.89826193
3	NUAK1	4.28637913
4	ACVR1B	3.28151584
5	TIE1	2.87233907
6	STK3	2.75176072
7	CAMKK2	2.56924089
8	ERBB3	2.54859659
9	ADRBK2	2.22043138
10	FRK	2.19945932
11	ICK	2.15599291
12	TAF1	1.85390529
13	BMPR1B	1.82480099
14	SMG1	1.78574935
15	TGFBR1	1.71937187
16	MATK	1.62998793
17	STK16	1.60560759
18	MAP2K3	1.58710129
19	WNK3	1.55070647
20	SCYL2	1.53987339
21	CAMK1D	1.41007091
22	PRKCQ	1.40688416
23	TGFBR2	1.35449187
24	JAK3	1.35437613
25	STK39	1.34486367
26	TNIK	1.34077978
27	MKNK1	1.31109651
28	SGK2	1.27672902
29	NEK2	1.27592814
30	CDK8	1.24268304
31	AKT3	1.19159163
32	PASK	1.14996628
33	EIF2AK1	1.09224707
34	NLK	1.08199855
35	CAMK1G	1.06957091
36	PTK2B	1.02097872
37	NEK1	1.01690831
38	EIF2AK3	0.97978678
39	FGFR2	0.88098067
40	FGFR3	0.86972386
41	INSRR	0.86570320
42	MKNK2	0.84470109
43	MAPK13	0.83293716
44	MAP3K10	0.81618059
45	SGK3	0.81531733
46	OXSR1	0.80412159
47	GRK1	0.78641061
48	PBK	0.78235123
49	TRIM28	0.76518283
50	BRSK2	0.76373538
51	SGK223	0.73224040
52	SGK494	0.73224040
53	STK24	0.71583401
54	EGFR	0.69842954
55	PAK3	0.67595315
56	PRKCE	0.66103442
57	MAP3K3	0.65987566
58	DYRK3	0.65805970
59	ADRBK1	0.64940241
60	CDK7	0.63328390
61	EPHB2	0.58802348
62	MAP3K4	0.55063593
63	MAP2K2	0.54990245
64	UHMK1	0.51968708
65	CAMKK1	0.50802189
66	PRKG1	0.50259701
67	WNK4	0.49668476
68	BCR	0.49594597
69	NME2	0.49211626
70	STK11	0.48423036
71	ZAK	0.48328784
72	PRPF4B	0.45572220
73	TRPM7	0.45187950
74	RPS6KA5	0.42877292
75	EPHA3	0.42346078
76	FGFR1	0.41297518
77	IRAK1	0.41250139
78	PLK2	0.39308163
79	CSK	0.38682849
80	MAP4K2	0.37674023
81	PRKAA1	0.37376492
82	OBSCN	0.36671638
83	ERBB2	0.34353297
84	MAP3K7	0.34155208
85	FER	0.33187401
86	PRKACA	0.31087646
87	MAP2K1	0.30900081
88	SIK2	0.28827201
89	GRK5	0.27216232
90	WNK1	0.26828129
91	MAP3K2	0.26560014
92	LCK	0.24147591
93	CAMK4	0.23914989
94	TEC	0.23587075
95	PINK1	0.22336966
96	TAOK2	0.21907765
97	PDGFRB	0.21720109
98	PRKACG	0.20891559
99	DYRK1A	0.20856577
100	CSNK1D	0.20694730

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Serotonergic synapse_Homo sapiens_hsa04726	3.51861854
2	Phototransduction_Homo sapiens_hsa04744	3.11376997
3	Taste transduction_Homo sapiens_hsa04742	2.91763706
4	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.80060962
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.62796631
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.46411456
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32114656
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.01184661
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.88358439
10	Protein export_Homo sapiens_hsa03060	1.86053923
11	Non-homologous end-joining_Homo sapiens_hsa03450	1.84731214
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.84021654
13	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.83381706
14	Butanoate metabolism_Homo sapiens_hsa00650	1.75797874
15	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.70399967
16	Sulfur relay system_Homo sapiens_hsa04122	1.69978706
17	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.64826063
18	Basal transcription factors_Homo sapiens_hsa03022	1.46991374
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.46527180
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.43012183
21	Ribosome_Homo sapiens_hsa03010	1.41172271
22	Long-term depression_Homo sapiens_hsa04730	1.40156619
23	Propanoate metabolism_Homo sapiens_hsa00640	1.39810173
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.38920659
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.36036951
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.35358228
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.32879448
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.27804801
29	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.24708942
30	ABC transporters_Homo sapiens_hsa02010	1.24168284
31	Axon guidance_Homo sapiens_hsa04360	1.23323767
32	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.22164314
33	Colorectal cancer_Homo sapiens_hsa05210	1.20852199
34	Notch signaling pathway_Homo sapiens_hsa04330	1.20134682
35	Collecting duct acid secretion_Homo sapiens_hsa04966	1.15518948
36	Retinol metabolism_Homo sapiens_hsa00830	1.15502137
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.13025307
38	Fatty acid elongation_Homo sapiens_hsa00062	1.12058644
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08958107
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07101919
41	Dopaminergic synapse_Homo sapiens_hsa04728	1.01301952
42	Circadian entrainment_Homo sapiens_hsa04713	0.98430682
43	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.94291030
44	Olfactory transduction_Homo sapiens_hsa04740	0.93733588
45	Morphine addiction_Homo sapiens_hsa05032	0.92929555
46	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.90986617
47	RNA transport_Homo sapiens_hsa03013	0.90977458
48	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.90945604
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.89346716
50	Glutathione metabolism_Homo sapiens_hsa00480	0.88362463
51	Selenocompound metabolism_Homo sapiens_hsa00450	0.87077324
52	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.86029160
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.83770124
54	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.79742858
55	Basal cell carcinoma_Homo sapiens_hsa05217	0.78142449
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.75938838
57	Choline metabolism in cancer_Homo sapiens_hsa05231	0.75156517
58	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.74395356
59	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.74098226
60	p53 signaling pathway_Homo sapiens_hsa04115	0.73816418
61	GABAergic synapse_Homo sapiens_hsa04727	0.71989159
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.69486185
63	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.68077187
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66935552
65	African trypanosomiasis_Homo sapiens_hsa05143	0.66741728
66	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.66535641
67	RNA polymerase_Homo sapiens_hsa03020	0.64116011
68	Alcoholism_Homo sapiens_hsa05034	0.63668929
69	Cholinergic synapse_Homo sapiens_hsa04725	0.63415881
70	Platelet activation_Homo sapiens_hsa04611	0.62410940
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.62259794
72	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.58068120
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57607028
74	mRNA surveillance pathway_Homo sapiens_hsa03015	0.57135238
75	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.52744234
76	ECM-receptor interaction_Homo sapiens_hsa04512	0.52286382
77	Pancreatic secretion_Homo sapiens_hsa04972	0.51933658
78	Legionellosis_Homo sapiens_hsa05134	0.50833098
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.47895927
80	Leishmaniasis_Homo sapiens_hsa05140	0.47402748
81	Ras signaling pathway_Homo sapiens_hsa04014	0.46504776
82	Protein digestion and absorption_Homo sapiens_hsa04974	0.46501536
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.45729236
84	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.45693858
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.44723898
86	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.44597306
87	Wnt signaling pathway_Homo sapiens_hsa04310	0.42708165
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.41151526
89	Peroxisome_Homo sapiens_hsa04146	0.41003797
90	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.40416581
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39593388
92	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.38754667
93	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.38399112
94	RNA degradation_Homo sapiens_hsa03018	0.38267361
95	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.36339988
96	Other glycan degradation_Homo sapiens_hsa00511	0.36126171
97	Lysosome_Homo sapiens_hsa04142	0.35825833
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.35508351
99	Fatty acid degradation_Homo sapiens_hsa00071	0.34434370
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.33925991

SLC25A14P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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