SLC25A15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.59220994
2L-phenylalanine catabolic process (GO:0006559)7.59220994
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.29366238
4L-phenylalanine metabolic process (GO:0006558)7.29366238
5aromatic amino acid family catabolic process (GO:0009074)6.86053263
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.26200462
7tryptophan catabolic process (GO:0006569)6.21137682
8indole-containing compound catabolic process (GO:0042436)6.21137682
9indolalkylamine catabolic process (GO:0046218)6.21137682
10kynurenine metabolic process (GO:0070189)6.04493281
11bile acid biosynthetic process (GO:0006699)5.92006870
12glyoxylate metabolic process (GO:0046487)5.89625116
13tryptophan metabolic process (GO:0006568)5.85231056
14cysteine metabolic process (GO:0006534)5.70410777
15alpha-linolenic acid metabolic process (GO:0036109)5.51689404
16* urea cycle (GO:0000050)5.48190716
17* urea metabolic process (GO:0019627)5.48190716
18negative regulation of fibrinolysis (GO:0051918)5.43473653
19high-density lipoprotein particle remodeling (GO:0034375)5.42573574
20sulfur amino acid catabolic process (GO:0000098)5.42142881
21epoxygenase P450 pathway (GO:0019373)5.34593284
22serine family amino acid catabolic process (GO:0009071)5.33584216
23regulation of protein activation cascade (GO:2000257)5.22794197
24complement activation, alternative pathway (GO:0006957)5.22573540
25omega-hydroxylase P450 pathway (GO:0097267)5.22343850
26regulation of fibrinolysis (GO:0051917)5.19832627
27protein carboxylation (GO:0018214)5.17735411
28peptidyl-glutamic acid carboxylation (GO:0017187)5.17735411
29homocysteine metabolic process (GO:0050667)5.11957514
30bile acid metabolic process (GO:0008206)5.04465767
31* nitrogen cycle metabolic process (GO:0071941)5.00218941
32aromatic amino acid family metabolic process (GO:0009072)4.99737349
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.99549498
34lysine catabolic process (GO:0006554)4.92073763
35lysine metabolic process (GO:0006553)4.92073763
36regulation of complement activation (GO:0030449)4.87907048
37regulation of triglyceride catabolic process (GO:0010896)4.86998007
38regulation of cholesterol esterification (GO:0010872)4.77653141
39tyrosine metabolic process (GO:0006570)4.77158845
40reverse cholesterol transport (GO:0043691)4.75390026
41amino-acid betaine metabolic process (GO:0006577)4.74089849
42alpha-amino acid catabolic process (GO:1901606)4.71378776
43plasma lipoprotein particle remodeling (GO:0034369)4.68348330
44protein-lipid complex remodeling (GO:0034368)4.68348330
45macromolecular complex remodeling (GO:0034367)4.68348330
46glycine metabolic process (GO:0006544)4.63333007
47acylglycerol homeostasis (GO:0055090)4.58740121
48triglyceride homeostasis (GO:0070328)4.58740121
49negative regulation of sterol transport (GO:0032372)4.55142363
50negative regulation of cholesterol transport (GO:0032375)4.55142363
51phospholipid efflux (GO:0033700)4.50620817
52serine family amino acid metabolic process (GO:0009069)4.46792329
53cellular ketone body metabolic process (GO:0046950)4.46122430
54bile acid and bile salt transport (GO:0015721)4.40304298
55indolalkylamine metabolic process (GO:0006586)4.38146029
56L-serine metabolic process (GO:0006563)4.36363499
57cellular amino acid catabolic process (GO:0009063)4.35215083
58serine family amino acid biosynthetic process (GO:0009070)4.32954946
59coenzyme catabolic process (GO:0009109)4.30223957
60cellular glucuronidation (GO:0052695)4.30044758
61glutamate metabolic process (GO:0006536)4.28907760
62amine catabolic process (GO:0009310)4.27292073
63cellular biogenic amine catabolic process (GO:0042402)4.27292073
64imidazole-containing compound metabolic process (GO:0052803)4.26210309
65plasma lipoprotein particle clearance (GO:0034381)4.26150352
66drug catabolic process (GO:0042737)4.22986851
67cellular modified amino acid catabolic process (GO:0042219)4.17665843
68cholesterol efflux (GO:0033344)4.15532298
69ethanol oxidation (GO:0006069)4.13883783
70benzene-containing compound metabolic process (GO:0042537)4.12740605
71arginine metabolic process (GO:0006525)4.06249604
72dicarboxylic acid biosynthetic process (GO:0043650)4.05397385
73proline metabolic process (GO:0006560)4.03538132
74plasma lipoprotein particle assembly (GO:0034377)4.01438680
75aldehyde catabolic process (GO:0046185)3.97833105
76nuclear pore complex assembly (GO:0051292)3.97037901
77proline biosynthetic process (GO:0006561)3.93595113
78fibrinolysis (GO:0042730)3.88427990
79regulation of bile acid biosynthetic process (GO:0070857)3.87293945
80ketone body metabolic process (GO:1902224)3.85862695
81low-density lipoprotein particle remodeling (GO:0034374)3.83667511
82positive regulation of lipoprotein lipase activity (GO:0051006)3.83443428
83positive regulation of triglyceride lipase activity (GO:0061365)3.83443428
84glucuronate metabolic process (GO:0019585)3.81264320
85uronic acid metabolic process (GO:0006063)3.81264320
86organic acid catabolic process (GO:0016054)3.79451661
87carboxylic acid catabolic process (GO:0046395)3.79451661
88acetyl-CoA metabolic process (GO:0006084)3.79158609
89very-low-density lipoprotein particle assembly (GO:0034379)3.79059464
90cholesterol homeostasis (GO:0042632)3.78328148
91urate metabolic process (GO:0046415)3.76597137
92regulation of cholesterol homeostasis (GO:2000188)3.76111399
93sterol homeostasis (GO:0055092)3.73272708
94short-chain fatty acid metabolic process (GO:0046459)3.72496506
95phospholipid homeostasis (GO:0055091)3.71889760
96blood coagulation, intrinsic pathway (GO:0007597)3.69230654
97tetrahydrofolate metabolic process (GO:0046653)3.68821635
98regulation of plasminogen activation (GO:0010755)3.68079164
99positive regulation of lipid catabolic process (GO:0050996)3.66043698
100complement activation, classical pathway (GO:0006958)3.66026040
101oxidative demethylation (GO:0070989)3.65819600
102drug transmembrane transport (GO:0006855)3.64813523
103cofactor catabolic process (GO:0051187)3.64349987
104protein-lipid complex assembly (GO:0065005)3.63058710
105aspartate family amino acid catabolic process (GO:0009068)3.63013120
106exogenous drug catabolic process (GO:0042738)3.62343655
107cytolysis (GO:0019835)3.60993542
108complement activation (GO:0006956)3.60367902
109protein activation cascade (GO:0072376)3.57877108
110drug metabolic process (GO:0017144)3.53501853
111nuclear pore organization (GO:0006999)3.51860491
112DNA strand elongation involved in DNA replication (GO:0006271)3.48397824
113folic acid-containing compound biosynthetic process (GO:0009396)3.45598123
114DNA unwinding involved in DNA replication (GO:0006268)3.41939346
115DNA strand elongation (GO:0022616)3.40584303
116ribosome assembly (GO:0042255)3.38285303
117telomere maintenance via semi-conservative replication (GO:0032201)3.20531527
118oxaloacetate metabolic process (GO:0006107)3.13135244
119IMP biosynthetic process (GO:0006188)3.09572567
120folic acid-containing compound metabolic process (GO:0006760)3.00355697
121DNA replication initiation (GO:0006270)2.96541097
122purine nucleobase biosynthetic process (GO:0009113)2.91734796
123establishment of integrated proviral latency (GO:0075713)2.90420689
124mitotic sister chromatid segregation (GO:0000070)2.90390391
125protein complex localization (GO:0031503)2.90041563
126ethanol metabolic process (GO:0006067)2.85551120
127glutamine family amino acid biosynthetic process (GO:0009084)2.85389103
128cellular protein complex localization (GO:0034629)2.84029563
129nucleobase biosynthetic process (GO:0046112)2.82878561
130regulation of translational fidelity (GO:0006450)2.81745682
131negative regulation of blood coagulation (GO:0030195)2.81474659
132negative regulation of hemostasis (GO:1900047)2.81474659
133IMP metabolic process (GO:0046040)2.80738139
134protein localization to chromosome, centromeric region (GO:0071459)2.79974979
135mitotic chromosome condensation (GO:0007076)2.77964467
136phenylpropanoid metabolic process (GO:0009698)2.76792467
137pore complex assembly (GO:0046931)2.74517453
138peptidyl-arginine omega-N-methylation (GO:0035247)2.74343920
139alpha-amino acid biosynthetic process (GO:1901607)2.74115371
140positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.72053208
141protein localization to kinetochore (GO:0034501)2.71328239
142telomere maintenance via recombination (GO:0000722)2.70089355
143pteridine-containing compound biosynthetic process (GO:0042559)2.69802153
144S-adenosylmethionine metabolic process (GO:0046500)2.69755214
145mitotic metaphase plate congression (GO:0007080)2.68769952
146mitotic nuclear envelope disassembly (GO:0007077)2.68683224
147sister chromatid segregation (GO:0000819)2.67491792
148protoporphyrinogen IX metabolic process (GO:0046501)2.65287064
149positive regulation of blood coagulation (GO:0030194)2.65007008
150positive regulation of hemostasis (GO:1900048)2.65007008
151glutamine family amino acid metabolic process (GO:0009064)2.63008676
152pteridine-containing compound metabolic process (GO:0042558)2.61914799
153protoporphyrinogen IX biosynthetic process (GO:0006782)2.61325810
154mitotic recombination (GO:0006312)2.59276165
155mitotic sister chromatid cohesion (GO:0007064)2.57044394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.44226308
2E2F7_22180533_ChIP-Seq_HELA_Human8.37282507
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.27908791
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.05453303
5* LXR_22158963_ChIP-Seq_LIVER_Mouse6.52390129
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.18369542
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.13494460
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.82202784
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.10660835
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03952375
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.89098029
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.61819929
13FOXM1_23109430_ChIP-Seq_U2OS_Human3.51724828
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32605893
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03062499
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01543448
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86742325
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64563736
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57742473
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42558806
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36545632
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.25818466
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25394102
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21272958
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.11098988
26* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.10921579
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08339539
28TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07464985
29* ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0132499
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99938315
31DCP1A_22483619_ChIP-Seq_HELA_Human1.98475670
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95640124
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92785922
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91405318
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89393640
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.82512954
37XRN2_22483619_ChIP-Seq_HELA_Human1.80695624
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75942532
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75421961
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.74043030
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.73059397
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67926979
43CLOCK_20551151_ChIP-Seq_293T_Human1.63312970
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.61961502
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59517279
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.58581838
47* GABP_19822575_ChIP-Seq_HepG2_Human1.58494921
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51264846
49* HNF4A_19822575_ChIP-Seq_HepG2_Human1.49799194
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48915123
51* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47488793
52HTT_18923047_ChIP-ChIP_STHdh_Human1.47437354
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45180571
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43814503
55TTF2_22483619_ChIP-Seq_HELA_Human1.40982611
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40385536
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40119849
58FOXP3_21729870_ChIP-Seq_TREG_Human1.39550454
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36637419
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29394807
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.29299410
62GATA1_22025678_ChIP-Seq_K562_Human1.28763699
63KDM5A_27292631_Chip-Seq_BREAST_Human1.28238636
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26972730
65ELK1_19687146_ChIP-ChIP_HELA_Human1.25513470
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25013962
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24136678
68RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21731446
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21529161
70* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19902099
71MYC_22102868_ChIP-Seq_BL_Human1.19250621
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19193390
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18289885
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15771725
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15304420
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14783885
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.09837809
78VDR_23849224_ChIP-Seq_CD4+_Human1.09648807
79SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09505773
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07927027
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05242314
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04091173
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02320057
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01457698
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97929232
86GATA4_25053715_ChIP-Seq_YYC3_Human0.97426782
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97369373
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97334016
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97207485
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96339558
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94593882
92KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94163266
93CHD1_26751641_Chip-Seq_LNCaP_Human0.93860448
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93524593
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93437922
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92585416
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92071973
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92008100
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90987411
100EGR1_19374776_ChIP-ChIP_THP-1_Human0.90696735
101* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89885847
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88054957
103TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88050142
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86836414
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86374157
106TFEB_21752829_ChIP-Seq_HELA_Human0.86039001
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85959811
108* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82646810
109* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82578687
110ZNF263_19887448_ChIP-Seq_K562_Human0.82369383
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80424020
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80245913
113SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79735048
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78827477
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78321699
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77643265
117RARA_24833708_ChIP-Seq_LIVER_Mouse0.76063480
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72241234
119RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72112236
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71221146
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.71011164
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69334786
123IRF8_22096565_ChIP-ChIP_GC-B_Human0.67246803
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.65352005
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.64312320
126RARB_24833708_ChIP-Seq_LIVER_Mouse0.63334731
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62245233
128CDX2_20551321_ChIP-Seq_CACO-2_Human0.62183504
129CEBPB_22108803_ChIP-Seq_LS180_Human0.61897155
130Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.60733823
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.60432470
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60242328
133ESR1_21235772_ChIP-Seq_MCF-7_Human0.59975775
134GATA6_25053715_ChIP-Seq_YYC3_Human0.59132302
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58261539
136RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56032287
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55990426
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55878543
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.54998724
140AR_21909140_ChIP-Seq_LNCAP_Human0.52418110
141ESET_19884257_ChIP-Seq_ESCs_Mouse0.52210312
142* AR_20517297_ChIP-Seq_VCAP_Human0.51052631
143STAT1_17558387_ChIP-Seq_HELA_Human0.50992411
144FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.50579524
145FOXO3_23340844_ChIP-Seq_DLD1_Human0.50204117
146PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49522828
147PPAR_26484153_Chip-Seq_NCI-H1993_Human0.48527274
148CBP_21632823_ChIP-Seq_H3396_Human0.48289165
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.48143298
150NRF2_20460467_ChIP-Seq_MEFs_Mouse0.48143298
151PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48056737
152MYC_19915707_ChIP-ChIP_AK7_Human0.47728857
153POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.47609620
154P53_21459846_ChIP-Seq_SAOS-2_Human0.45787613
155EGR1_19032775_ChIP-ChIP_M12_Human0.43846503
156* LXR_22292898_ChIP-Seq_THP-1_Human0.41885383
157TAF2_19829295_ChIP-Seq_ESCs_Human0.41356720
158PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.40681129
159CDX2_22108803_ChIP-Seq_LS180_Human0.40414660
160CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39422852
161ERG_20517297_ChIP-Seq_VCAP_Human0.38687820
162GATA2_19941826_ChIP-Seq_K562_Human0.38472025
163ESR1_20079471_ChIP-ChIP_T-47D_Human0.38460463
164GATA3_24758297_ChIP-Seq_MCF-7_Human0.38325275
165PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.38231415
166SPI1_26923725_Chip-Seq_HPCs_Mouse0.37518594
167STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36592457
168IRF1_19129219_ChIP-ChIP_H3396_Human0.36318711
169FOXH1_21741376_ChIP-Seq_EPCs_Human0.35788295
170* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34660555
171GATA1_19941827_ChIP-Seq_MEL_Mouse0.34629194
172SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34453187
173SOX2_20726797_ChIP-Seq_SW620_Human0.33914343
174GATA1_19941826_ChIP-Seq_K562_Human0.33795082
175LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.33609389
176GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.33572144
177SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33140227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.21501585
2MP0005360_urolithiasis7.92419685
3MP0005085_abnormal_gallbladder_physiolo6.36740620
4MP0005365_abnormal_bile_salt6.10751713
5MP0008875_abnormal_xenobiotic_pharmacok4.99733554
6MP0003806_abnormal_nucleotide_metabolis4.35567732
7MP0003252_abnormal_bile_duct3.96463727
8MP0010329_abnormal_lipoprotein_level3.49515405
9MP0003693_abnormal_embryo_hatching3.44244568
10MP0009840_abnormal_foam_cell3.28114011
11MP0003111_abnormal_nucleus_morphology3.14272488
12MP0010094_abnormal_chromosome_stability3.09224818
13MP0004957_abnormal_blastocyst_morpholog3.04813100
14MP0005083_abnormal_biliary_tract2.91049634
15MP0005332_abnormal_amino_acid2.89186020
16MP0001666_abnormal_nutrient_absorption2.75147364
17MP0003195_calcinosis2.73143488
18MP0003077_abnormal_cell_cycle2.39501005
19MP0004019_abnormal_vitamin_homeostasis2.31681482
20MP0008057_abnormal_DNA_replication2.27793263
21MP0003191_abnormal_cellular_cholesterol2.22830611
22MP0000609_abnormal_liver_physiology2.13543934
23MP0008932_abnormal_embryonic_tissue2.04399550
24MP0002118_abnormal_lipid_homeostasis2.03679581
25MP0002138_abnormal_hepatobiliary_system2.02809913
26MP0001730_embryonic_growth_arrest1.93502701
27MP0008058_abnormal_DNA_repair1.86227887
28MP0003868_abnormal_feces_composition1.84257400
29MP0005319_abnormal_enzyme/_coenzyme1.80762993
30MP0003941_abnormal_skin_development1.78569694
31MP0008007_abnormal_cellular_replicative1.73098673
32MP0001764_abnormal_homeostasis1.67847180
33MP0005451_abnormal_body_composition1.64378751
34MP0009697_abnormal_copulation1.63099980
35MP0005584_abnormal_enzyme/coenzyme_acti1.53030970
36MP0010352_gastrointestinal_tract_polyps1.48970063
37MP0000350_abnormal_cell_proliferation1.38758255
38MP0009643_abnormal_urine_homeostasis1.38038416
39MP0003186_abnormal_redox_activity1.32818298
40MP0001697_abnormal_embryo_size1.32313603
41MP0003705_abnormal_hypodermis_morpholog1.29293656
42MP0003011_delayed_dark_adaptation1.28345360
43MP0001672_abnormal_embryogenesis/_devel1.27645932
44MP0005380_embryogenesis_phenotype1.27645932
45MP0002396_abnormal_hematopoietic_system1.24800362
46MP0002877_abnormal_melanocyte_morpholog1.22766299
47MP0003984_embryonic_growth_retardation1.21817780
48MP0002080_prenatal_lethality1.18889887
49MP0000598_abnormal_liver_morphology1.18052069
50MP0000537_abnormal_urethra_morphology1.16177587
51MP0002088_abnormal_embryonic_growth/wei1.15923647
52MP0003656_abnormal_erythrocyte_physiolo1.15806332
53MP0005647_abnormal_sex_gland1.10146444
54MP0001915_intracranial_hemorrhage1.09954753
55MP0002132_abnormal_respiratory_system1.08954134
56MP0002086_abnormal_extraembryonic_tissu1.05188884
57MP0003566_abnormal_cell_adhesion1.02964449
58MP0005636_abnormal_mineral_homeostasis1.01474620
59MP0005501_abnormal_skin_physiology1.01254900
60MP0010307_abnormal_tumor_latency1.01179318
61MP0004185_abnormal_adipocyte_glucose0.99514822
62MP0002697_abnormal_eye_size0.99361943
63MP0009764_decreased_sensitivity_to0.98481500
64MP0009763_increased_sensitivity_to0.97516658
65MP0000604_amyloidosis0.95368981
66MP0002085_abnormal_embryonic_tissue0.95029123
67MP0005408_hypopigmentation0.94345835
68MP0002254_reproductive_system_inflammat0.93399139
69MP0002084_abnormal_developmental_patter0.93112160
70MP0003786_premature_aging0.92987252
71MP0003315_abnormal_perineum_morphology0.90790330
72MP0004233_abnormal_muscle_weight0.88710116
73MP0010368_abnormal_lymphatic_system0.87751916
74MP0000313_abnormal_cell_death0.87085272
75MP0006036_abnormal_mitochondrial_physio0.87035178
76MP0001293_anophthalmia0.86855500
77MP0005187_abnormal_penis_morphology0.86627713
78MP0009642_abnormal_blood_homeostasis0.85254352
79MP0005084_abnormal_gallbladder_morpholo0.84512370
80MP0008469_abnormal_protein_level0.83254249
81MP0002009_preneoplasia0.82532854
82MP0000358_abnormal_cell_content/0.80914924
83MP0005376_homeostasis/metabolism_phenot0.80223897
84MP0005220_abnormal_exocrine_pancreas0.79996906
85MP0003890_abnormal_embryonic-extraembry0.78830050
86MP0005670_abnormal_white_adipose0.78248344
87MP0009765_abnormal_xenobiotic_induced0.76997862
88MP0005076_abnormal_cell_differentiation0.76709273
89MP0010030_abnormal_orbit_morphology0.74022382
90MP0003718_maternal_effect0.73798610
91MP0002078_abnormal_glucose_homeostasis0.73720202
92MP0002092_abnormal_eye_morphology0.73565169
93MP0004272_abnormal_basement_membrane0.72952728
94MP0004147_increased_porphyrin_level0.72308132
95MP0005266_abnormal_metabolism0.71681851
96MP0002019_abnormal_tumor_incidence0.71603607
97MP0004197_abnormal_fetal_growth/weight/0.70489180
98MP0002971_abnormal_brown_adipose0.69418991
99MP0001661_extended_life_span0.67997873
100MP0001756_abnormal_urination0.67687040
101MP0009053_abnormal_anal_canal0.67626350
102MP0002876_abnormal_thyroid_physiology0.67345159
103MP0002089_abnormal_postnatal_growth/wei0.64585961
104MP0005334_abnormal_fat_pad0.63384624
105MP0000490_abnormal_crypts_of0.62732475
106MP0001727_abnormal_embryo_implantation0.61813845
107MP0000467_abnormal_esophagus_morphology0.61522171
108MP0005395_other_phenotype0.60090739
109MP0005535_abnormal_body_temperature0.59434813
110MP0006035_abnormal_mitochondrial_morpho0.58907561
111MP0003943_abnormal_hepatobiliary_system0.58307446
112MP0004130_abnormal_muscle_cell0.58255050
113MP0005384_cellular_phenotype0.57888102
114MP0000627_abnormal_mammary_gland0.57201006
115MP0002136_abnormal_kidney_physiology0.56721618
116MP0000639_abnormal_adrenal_gland0.56602239
117MP0003329_amyloid_beta_deposits0.51548471
118MP0003690_abnormal_glial_cell0.51460135
119MP0005448_abnormal_energy_balance0.50179113
120MP0004264_abnormal_extraembryonic_tissu0.47891498
121MP0002928_abnormal_bile_duct0.45818243
122MP0005464_abnormal_platelet_physiology0.44638794
123MP0008873_increased_physiological_sensi0.44415477
124MP0005666_abnormal_adipose_tissue0.43752534
125MP0003638_abnormal_response/metabolism_0.42602125
126MP0004782_abnormal_surfactant_physiolog0.41904931
127MP0002796_impaired_skin_barrier0.41117533
128MP0009384_cardiac_valve_regurgitation0.40803050
129MP0004043_abnormal_pH_regulation0.40657605
130MP0000579_abnormal_nail_morphology0.39725149
131MP0009672_abnormal_birth_weight0.39500827
132MP0003953_abnormal_hormone_level0.38679364
133MP0008874_decreased_physiological_sensi0.37094639
134MP0010234_abnormal_vibrissa_follicle0.36581506
135MP0002822_catalepsy0.36505416
136MP0008872_abnormal_physiological_respon0.36144823
137MP0005166_decreased_susceptibility_to0.35750416
138MP0005248_abnormal_Harderian_gland0.34242030
139MP0009115_abnormal_fat_cell0.33556468
140MP0003724_increased_susceptibility_to0.31696432
141MP0002168_other_aberrant_phenotype0.31187784
142MP0002970_abnormal_white_adipose0.30529385
143MP0000230_abnormal_systemic_arterial0.30384995
144MP0004381_abnormal_hair_follicle0.30270667
145MP0003075_altered_response_to0.28810736
146MP0003436_decreased_susceptibility_to0.28128874
147MP0001243_abnormal_dermal_layer0.27991826
148MP0001765_abnormal_ion_homeostasis0.27469072
149MP0001881_abnormal_mammary_gland0.27313602
150MP0000427_abnormal_hair_cycle0.26543003
151MP0000249_abnormal_blood_vessel0.25987884
152MP0003699_abnormal_female_reproductive0.25776166
153MP0002135_abnormal_kidney_morphology0.25765164
154MP0002837_dystrophic_cardiac_calcinosis0.25264961
155MP0003453_abnormal_keratinocyte_physiol0.25063029

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.36494889
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.32186852
3Deep venous thrombosis (HP:0002625)7.19887418
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.77142808
5Hypobetalipoproteinemia (HP:0003563)6.54602883
6Xanthomatosis (HP:0000991)6.27448297
7Prolonged partial thromboplastin time (HP:0003645)6.23520943
8Hyperlipoproteinemia (HP:0010980)5.35879334
9Complement deficiency (HP:0004431)5.24107298
10Hypolipoproteinemia (HP:0010981)4.83487594
11Hyperglycinemia (HP:0002154)4.59931049
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.54902969
13* Hyperammonemia (HP:0001987)4.54474639
14Joint hemorrhage (HP:0005261)4.54337056
15Epidermoid cyst (HP:0200040)4.48470226
16Abnormality of sulfur amino acid metabolism (HP:0004339)4.44627700
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.39496068
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.37614460
19Ketosis (HP:0001946)4.32334654
20Abnormality of the common coagulation pathway (HP:0010990)4.31943915
21Hyperglycinuria (HP:0003108)4.31481021
22Abnormality of methionine metabolism (HP:0010901)4.29925958
23Fat malabsorption (HP:0002630)4.25541402
24Abnormality of serine family amino acid metabolism (HP:0010894)4.21485463
25Abnormality of glycine metabolism (HP:0010895)4.21485463
26Hypoalphalipoproteinemia (HP:0003233)4.10836757
27Abnormality of pyrimidine metabolism (HP:0004353)4.02855793
28Hypoglycemic coma (HP:0001325)3.89578336
29Abnormality of complement system (HP:0005339)3.80728006
30Conjugated hyperbilirubinemia (HP:0002908)3.77703026
31Abnormality of the intrinsic pathway (HP:0010989)3.65355681
32Hypercholesterolemia (HP:0003124)3.54303090
33Abnormality of fatty-acid metabolism (HP:0004359)3.41735882
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34927732
35Abnormality of nucleobase metabolism (HP:0010932)3.31170759
36Hyperbilirubinemia (HP:0002904)3.30579297
37Increased serum pyruvate (HP:0003542)3.22983920
38Abnormality of serum amino acid levels (HP:0003112)3.22519364
39Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15225374
40Delayed CNS myelination (HP:0002188)3.15133352
41Ketoacidosis (HP:0001993)3.13633974
42Abnormality of glycolysis (HP:0004366)3.12247145
43Steatorrhea (HP:0002570)3.12215782
44Hepatocellular carcinoma (HP:0001402)2.99203323
45Chromsome breakage (HP:0040012)2.95702388
46Abnormality of purine metabolism (HP:0004352)2.95328243
47Spontaneous abortion (HP:0005268)2.95175348
48Increased mean platelet volume (HP:0011877)2.91102169
49Hypochromic microcytic anemia (HP:0004840)2.89116921
50Metabolic acidosis (HP:0001942)2.85900861
51Myocardial infarction (HP:0001658)2.85817654
52Reduced antithrombin III activity (HP:0001976)2.85267989
53Gout (HP:0001997)2.83542943
54Acanthocytosis (HP:0001927)2.73303445
55Skin nodule (HP:0200036)2.73083357
56Dicarboxylic aciduria (HP:0003215)2.66860433
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66860433
58Spastic diplegia (HP:0001264)2.63083127
59Vascular calcification (HP:0004934)2.61682115
60* Lethargy (HP:0001254)2.61248799
61Malnutrition (HP:0004395)2.59787471
62Multiple enchondromatosis (HP:0005701)2.56320088
63Systemic lupus erythematosus (HP:0002725)2.55801630
64Abnormal platelet volume (HP:0011876)2.47338169
65Hypoglycemic seizures (HP:0002173)2.44468907
66Reticulocytosis (HP:0001923)2.44033960
67Cerebral edema (HP:0002181)2.43210487
68Irritability (HP:0000737)2.41756626
69Neonatal onset (HP:0003623)2.39410766
70Abnormal gallbladder morphology (HP:0012437)2.35580854
71Microvesicular hepatic steatosis (HP:0001414)2.32381654
72Cardiovascular calcification (HP:0011915)2.31429548
73Cholelithiasis (HP:0001081)2.30445511
74Glomerulonephritis (HP:0000099)2.26545439
75Abnormal gallbladder physiology (HP:0012438)2.25775638
76Cholecystitis (HP:0001082)2.25775638
77Generalized aminoaciduria (HP:0002909)2.22255451
78Sensorimotor neuropathy (HP:0007141)2.21600735
79Pancreatitis (HP:0001733)2.20925894
80Esophageal varix (HP:0002040)2.20391976
81Mitral stenosis (HP:0001718)2.17445434
82Late onset (HP:0003584)2.17083619
83Amyloidosis (HP:0011034)2.14636207
84Recurrent gram-negative bacterial infections (HP:0005420)2.13856714
85Enlarged kidneys (HP:0000105)2.12380405
86Gingival bleeding (HP:0000225)2.09278431
87Alkalosis (HP:0001948)2.08627381
88Brushfield spots (HP:0001088)2.07381281
89Proximal tubulopathy (HP:0000114)2.07043015
90Poikilocytosis (HP:0004447)2.05573014
91Abnormality of the preputium (HP:0100587)2.05555806
92* Vomiting (HP:0002013)2.05360411
93Rickets (HP:0002748)2.03939806
94Thrombophlebitis (HP:0004418)2.02780581
95Hydroxyprolinuria (HP:0003080)2.02242467
96Abnormality of proline metabolism (HP:0010907)2.02242467
97Menorrhagia (HP:0000132)2.02133072
98Hyperinsulinemic hypoglycemia (HP:0000825)2.01924698
99Hyperuricemia (HP:0002149)1.98483040
100Increased purine levels (HP:0004368)1.98483040
101Asymmetry of the thorax (HP:0001555)1.95873646
102Opisthotonus (HP:0002179)1.94476518
103Abnormal cartilage morphology (HP:0002763)1.94379926
104Progressive external ophthalmoplegia (HP:0000590)1.93426706
105Abnormality of the gallbladder (HP:0005264)1.92855118
106Glycosuria (HP:0003076)1.91766148
107Abnormality of urine glucose concentration (HP:0011016)1.91766148
108Abnormality of transition element cation homeostasis (HP:0011030)1.91717570
109Abnormal enzyme/coenzyme activity (HP:0012379)1.91688987
110Progressive muscle weakness (HP:0003323)1.91344859
111Abnormality of reticulocytes (HP:0004312)1.91180988
112Abnormality of iron homeostasis (HP:0011031)1.90262964
113Meckel diverticulum (HP:0002245)1.89786369
114Abnormal platelet function (HP:0011869)1.89783037
115Impaired platelet aggregation (HP:0003540)1.89783037
116Renal cortical cysts (HP:0000803)1.87370625
117Abnormality of vitamin metabolism (HP:0100508)1.86773908
118Hemorrhage of the eye (HP:0011885)1.85634286
119Abnormality of chromosome stability (HP:0003220)1.84805318
120Abnormality of the Achilles tendon (HP:0005109)1.79783685
121Abnormality of the ileum (HP:0001549)1.77951610
122Nephroblastoma (Wilms tumor) (HP:0002667)1.75246245
123Aplasia/Hypoplasia of the uvula (HP:0010293)1.71727637
124Microglossia (HP:0000171)1.71212065
125Elevated alkaline phosphatase (HP:0003155)1.70572435
126Abnormality of the heme biosynthetic pathway (HP:0010472)1.70463571
127Abnormality of alanine metabolism (HP:0010916)1.69771147
128Hyperalaninemia (HP:0003348)1.69771147
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69771147
130Abnormality of the umbilical cord (HP:0010881)1.69094006
131Megaloblastic anemia (HP:0001889)1.69054793
132Increased nuchal translucency (HP:0010880)1.65296072
133Embryonal renal neoplasm (HP:0011794)1.65291130
134Birth length less than 3rd percentile (HP:0003561)1.62914145
135Abnormal delivery (HP:0001787)1.61750784
136Myelodysplasia (HP:0002863)1.60465452
137Abnormality of the fetal cardiovascular system (HP:0010948)1.59173757
138Abnormal umbilical cord blood vessels (HP:0011403)1.59173757
139Single umbilical artery (HP:0001195)1.59173757
140Small intestinal stenosis (HP:0012848)1.57995396
141Duodenal stenosis (HP:0100867)1.57995396
142Neonatal hypoglycemia (HP:0001998)1.57640705
143Pancreatic islet-cell hyperplasia (HP:0004510)1.55257284
144Abnormalities of placenta or umbilical cord (HP:0001194)1.54492040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.24174675
2BUB14.40967366
3FGFR44.31623975
4ERN14.20791373
5SIK14.01813068
6ERBB43.45170012
7SCYL23.41250854
8TAOK33.30064721
9EIF2AK13.21641141
10CDC73.02079941
11VRK22.57516835
12INSRR2.56967489
13SMG12.55844617
14SRPK12.55764026
15EIF2AK32.52469009
16LATS12.51101574
17PKN22.41746347
18TSSK62.37815401
19MST1R2.23990358
20NME22.12201958
21MAPK112.10338052
22MAP2K42.08675928
23PLK41.99146628
24FRK1.98424663
25FLT31.93292920
26ZAK1.92122208
27BRSK21.91561353
28TRIB31.75482918
29PIK3CG1.74710788
30STK38L1.74535101
31WEE11.67834025
32MST41.67694999
33EEF2K1.66064606
34NEK91.60216255
35TAF11.59254995
36PTK61.55328753
37TYK21.52463265
38ABL21.51295758
39CDK71.50105137
40PLK31.42120572
41MKNK11.39984862
42CHEK21.38644540
43CDK121.35199685
44TRIM281.33043983
45VRK11.29465762
46PAK41.27600747
47GRK61.27473973
48RPS6KB21.26494129
49PRKAA21.24046161
50NEK21.22038244
51ATR1.21319445
52PLK11.20981385
53BRSK11.18198797
54JAK21.17818452
55MAP3K101.16399478
56FGFR21.15316458
57MAP3K71.15073497
58EIF2AK21.11843254
59AURKB1.08987241
60PINK11.08063354
61ERBB21.06791545
62KDR1.05148596
63ALK1.03110861
64DAPK21.02461509
65STK160.99152955
66MAP3K120.98908265
67MAP2K30.98207934
68TAOK20.93310533
69MET0.92760305
70CDK60.90650581
71MAP3K30.90325357
72AURKA0.89899323
73CHEK10.89414742
74PIM20.85245838
75MAPK40.83880893
76BRD40.82236898
77PRKAA10.80791328
78MAP3K110.80594619
79DAPK10.80422051
80PRKCZ0.79803283
81MAP3K60.78381351
82LATS20.77826754
83MKNK20.77530476
84ILK0.75087902
85ATM0.74613405
86TBK10.72508539
87JAK10.70699138
88RAF10.70302478
89RIPK10.70133691
90NME10.69101264
91CDK40.68706761
92IRAK30.68689780
93GSK3A0.68124419
94MAP2K60.68096497
95BCR0.67811156
96PDK20.66982065
97PRKACG0.66072534
98MUSK0.65708865
99PRPF4B0.64527639
100EPHB10.63832364
101DYRK1B0.62167590
102CDK80.61854189
103CSNK1G10.60597250
104MAPK120.60376595
105PTK20.59753809
106MAP3K140.57828722
107SGK30.57723777
108MAPK150.57302744
109NEK10.56818426
110SIK30.56781507
111CAMK2G0.56759283
112CLK10.55431095
113CAMK1D0.53603026
114STK30.53244826
115STK40.52716854
116RPS6KA40.51208048
117AKT20.51042051
118CSK0.50474583
119EPHA30.49697032
120TIE10.49142706
121MAP3K50.49055496
122CSNK2A20.48825583
123NTRK10.48477203
124MTOR0.48059581
125PDPK10.47406293
126CDK20.47184896
127CSNK2A10.46237125
128CDK10.45970981
129PDK30.45034838
130PDK40.45034838
131PDGFRA0.44488877
132TESK10.42720459
133PBK0.42571758
134TLK10.42381092
135MAP2K10.41766959
136MELK0.41462611
137SGK20.41214630
138CDK90.40166782
139CSNK1E0.39696592
140MAPK70.39037570
141FGFR30.38869644
142MAP3K130.38615984
143GRK10.38456050
144PRKCQ0.37612115
145CSF1R0.37507633
146IGF1R0.36303544
147RET0.35705991
148PASK0.35231356
149FGFR10.33617579
150BMX0.33537301
151PAK20.32926959
152EPHA20.32768372
153SGK4940.32565801
154SGK2230.32565801
155KSR20.32277961
156TGFBR20.31444878
157MAP2K20.30581317
158PRKCI0.30368977
159WNK30.29797285
160CSNK1G30.29299187
161RPS6KB10.28683336
162ICK0.28454736
163IKBKE0.28069672
164TTK0.27631620
165ACVR1B0.27585445
166WNK40.27005056
167CSNK1G20.26182111
168PDK10.25685385
169NUAK10.24864725
170EGFR0.24359599
171MAP3K10.24316712
172MAP3K80.23561384
173STK380.23375806

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.38853145
2Nitrogen metabolism_Homo sapiens_hsa009103.66616474
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39134349
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35852991
5Arginine biosynthesis_Homo sapiens_hsa002203.09085933
6Tryptophan metabolism_Homo sapiens_hsa003802.68171027
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67046849
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.59891233
9Complement and coagulation cascades_Homo sapiens_hsa046102.59867205
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57001360
11Fatty acid degradation_Homo sapiens_hsa000712.48504694
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42094367
13DNA replication_Homo sapiens_hsa030302.31390924
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26933976
15Butanoate metabolism_Homo sapiens_hsa006502.15801331
16Peroxisome_Homo sapiens_hsa041462.07864394
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07501074
18Propanoate metabolism_Homo sapiens_hsa006401.96594226
19Histidine metabolism_Homo sapiens_hsa003401.90220857
20Chemical carcinogenesis_Homo sapiens_hsa052041.86673423
21Mismatch repair_Homo sapiens_hsa034301.85172442
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85092225
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.83528507
24PPAR signaling pathway_Homo sapiens_hsa033201.82041320
25Fatty acid metabolism_Homo sapiens_hsa012121.77997069
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.77067918
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.75424129
28beta-Alanine metabolism_Homo sapiens_hsa004101.72383265
29Caffeine metabolism_Homo sapiens_hsa002321.71814326
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67002390
31Retinol metabolism_Homo sapiens_hsa008301.64729669
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64680535
33Selenocompound metabolism_Homo sapiens_hsa004501.64556584
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61834071
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59043659
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59006415
37Staphylococcus aureus infection_Homo sapiens_hsa051501.57858798
38Phenylalanine metabolism_Homo sapiens_hsa003601.52463106
39Bile secretion_Homo sapiens_hsa049761.50589886
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45466269
41Pyruvate metabolism_Homo sapiens_hsa006201.40520238
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.39657246
43Tyrosine metabolism_Homo sapiens_hsa003501.38132368
44Folate biosynthesis_Homo sapiens_hsa007901.35076881
45Sulfur metabolism_Homo sapiens_hsa009201.35041869
46Starch and sucrose metabolism_Homo sapiens_hsa005001.32648096
47Fat digestion and absorption_Homo sapiens_hsa049751.29367015
48Biosynthesis of amino acids_Homo sapiens_hsa012301.28929239
49Non-homologous end-joining_Homo sapiens_hsa034501.25527380
50Base excision repair_Homo sapiens_hsa034101.25419427
51Fatty acid elongation_Homo sapiens_hsa000621.25373834
52Proteasome_Homo sapiens_hsa030501.24785081
53Carbon metabolism_Homo sapiens_hsa012001.19573950
54Steroid biosynthesis_Homo sapiens_hsa001001.18155930
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.16101307
56ABC transporters_Homo sapiens_hsa020101.14645888
57Cell cycle_Homo sapiens_hsa041101.13605444
58Nucleotide excision repair_Homo sapiens_hsa034201.10539521
59Vitamin digestion and absorption_Homo sapiens_hsa049771.05331746
60RNA transport_Homo sapiens_hsa030131.04929701
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.04865282
62Vitamin B6 metabolism_Homo sapiens_hsa007501.04209611
63Arginine and proline metabolism_Homo sapiens_hsa003301.03623749
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00898150
65Spliceosome_Homo sapiens_hsa030400.98371685
66Homologous recombination_Homo sapiens_hsa034400.96466926
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93287764
68Sulfur relay system_Homo sapiens_hsa041220.93129852
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91924886
70One carbon pool by folate_Homo sapiens_hsa006700.87085534
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86038119
72Lysine degradation_Homo sapiens_hsa003100.85365900
73Fanconi anemia pathway_Homo sapiens_hsa034600.79253973
74Glutathione metabolism_Homo sapiens_hsa004800.76145498
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75446594
76Glycerolipid metabolism_Homo sapiens_hsa005610.70696614
77Thyroid cancer_Homo sapiens_hsa052160.68949895
78Pentose phosphate pathway_Homo sapiens_hsa000300.63543525
79RNA polymerase_Homo sapiens_hsa030200.61333609
80mRNA surveillance pathway_Homo sapiens_hsa030150.60500302
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58813160
82Fatty acid biosynthesis_Homo sapiens_hsa000610.50758704
83N-Glycan biosynthesis_Homo sapiens_hsa005100.49353705
84Metabolic pathways_Homo sapiens_hsa011000.47999338
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47239179
86Purine metabolism_Homo sapiens_hsa002300.42132947
87RNA degradation_Homo sapiens_hsa030180.38467908
88Basal transcription factors_Homo sapiens_hsa030220.36835667
89p53 signaling pathway_Homo sapiens_hsa041150.34864825
90Galactose metabolism_Homo sapiens_hsa000520.34159340
91Fructose and mannose metabolism_Homo sapiens_hsa000510.32506426
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29436155
93Prion diseases_Homo sapiens_hsa050200.29393140
94Linoleic acid metabolism_Homo sapiens_hsa005910.24187853
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22107117
96Insulin resistance_Homo sapiens_hsa049310.20328412
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19679369
98Viral carcinogenesis_Homo sapiens_hsa052030.17657775
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.17448681
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.17243960
101Ribosome_Homo sapiens_hsa030100.16186883
102Alcoholism_Homo sapiens_hsa050340.13769149
103Glucagon signaling pathway_Homo sapiens_hsa049220.06610667
104AMPK signaling pathway_Homo sapiens_hsa041520.02846431
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00601935
106Pyrimidine metabolism_Homo sapiens_hsa00240-0.2368238
107African trypanosomiasis_Homo sapiens_hsa05143-0.2278705
108Ether lipid metabolism_Homo sapiens_hsa00565-0.2177872
109Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1920806
110Protein digestion and absorption_Homo sapiens_hsa04974-0.1905206
111Bladder cancer_Homo sapiens_hsa05219-0.1871783
112Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1788194
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1736693
114Hepatitis C_Homo sapiens_hsa05160-0.1724718
115Mineral absorption_Homo sapiens_hsa04978-0.1646253
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1637337
117Regulation of autophagy_Homo sapiens_hsa04140-0.1597040
118Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1525947
119Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1470330
120Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1163695
121Insulin signaling pathway_Homo sapiens_hsa04910-0.1156017
122Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1153918
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0940670
124Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0482851
125Renin-angiotensin system_Homo sapiens_hsa04614-0.0348629

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