SLC25A16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains three tandemly repeated mitochondrial carrier protein domains. The encoded protein is localized in the inner membrane and facilitates the rapid transport and exchange of molecules between the cytosol and the mitochondrial matrix space. This gene has a possible role in Graves' disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.97117839
2L-phenylalanine catabolic process (GO:0006559)6.97117839
3L-phenylalanine metabolic process (GO:0006558)6.63949607
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.63949607
5aromatic amino acid family catabolic process (GO:0009074)6.36602674
6cysteine metabolic process (GO:0006534)5.78876241
7tryptophan catabolic process (GO:0006569)5.78053719
8indole-containing compound catabolic process (GO:0042436)5.78053719
9indolalkylamine catabolic process (GO:0046218)5.78053719
10behavioral response to nicotine (GO:0035095)5.72000873
11kynurenine metabolic process (GO:0070189)5.55977109
12glyoxylate metabolic process (GO:0046487)5.55326748
13lysine metabolic process (GO:0006553)5.48002694
14lysine catabolic process (GO:0006554)5.48002694
15tryptophan metabolic process (GO:0006568)5.44537074
16bile acid biosynthetic process (GO:0006699)5.37775343
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.29981659
18alpha-linolenic acid metabolic process (GO:0036109)5.24516765
19sulfur amino acid catabolic process (GO:0000098)4.98074351
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.94542730
21serine family amino acid catabolic process (GO:0009071)4.93109863
22urea cycle (GO:0000050)4.91645068
23urea metabolic process (GO:0019627)4.91645068
24homocysteine metabolic process (GO:0050667)4.73893002
25cellular ketone body metabolic process (GO:0046950)4.66413653
26amino-acid betaine metabolic process (GO:0006577)4.65947675
27peptidyl-glutamic acid carboxylation (GO:0017187)4.61481785
28protein carboxylation (GO:0018214)4.61481785
29aromatic amino acid family metabolic process (GO:0009072)4.61243703
30bile acid metabolic process (GO:0008206)4.58037531
31complement activation, alternative pathway (GO:0006957)4.56426937
32nitrogen cycle metabolic process (GO:0071941)4.53246832
33alpha-amino acid catabolic process (GO:1901606)4.52455537
34high-density lipoprotein particle remodeling (GO:0034375)4.51304913
35negative regulation of fibrinolysis (GO:0051918)4.49410320
36fucose catabolic process (GO:0019317)4.43729355
37L-fucose metabolic process (GO:0042354)4.43729355
38L-fucose catabolic process (GO:0042355)4.43729355
39regulation of fibrinolysis (GO:0051917)4.39163883
40regulation of protein activation cascade (GO:2000257)4.38604444
41glutamate metabolic process (GO:0006536)4.37773008
42short-chain fatty acid metabolic process (GO:0046459)4.32653461
43regulation of triglyceride catabolic process (GO:0010896)4.31333040
44cellular amino acid catabolic process (GO:0009063)4.26260178
45tyrosine metabolic process (GO:0006570)4.25640046
46triglyceride homeostasis (GO:0070328)4.11963933
47acylglycerol homeostasis (GO:0055090)4.11963933
48regulation of complement activation (GO:0030449)4.11406084
49indolalkylamine metabolic process (GO:0006586)4.09669299
50drug transmembrane transport (GO:0006855)4.08056125
51drug catabolic process (GO:0042737)4.08027764
52cellular modified amino acid catabolic process (GO:0042219)4.07863537
53coenzyme catabolic process (GO:0009109)4.07598678
54serine family amino acid metabolic process (GO:0009069)4.06974812
55urate metabolic process (GO:0046415)4.06506251
56aspartate family amino acid catabolic process (GO:0009068)4.05905192
57acetyl-CoA metabolic process (GO:0006084)4.05733712
58ketone body metabolic process (GO:1902224)4.00507871
59dicarboxylic acid biosynthetic process (GO:0043650)3.97236764
602-oxoglutarate metabolic process (GO:0006103)3.96274310
61protein-lipid complex remodeling (GO:0034368)3.96028770
62macromolecular complex remodeling (GO:0034367)3.96028770
63plasma lipoprotein particle remodeling (GO:0034369)3.96028770
64cellular glucuronidation (GO:0052695)3.93707423
65amine catabolic process (GO:0009310)3.93015314
66cellular biogenic amine catabolic process (GO:0042402)3.93015314
67ethanol oxidation (GO:0006069)3.92679484
68reverse cholesterol transport (GO:0043691)3.92518440
69negative regulation of cholesterol transport (GO:0032375)3.89920914
70negative regulation of sterol transport (GO:0032372)3.89920914
71fatty acid beta-oxidation (GO:0006635)3.86381944
72fatty acid oxidation (GO:0019395)3.83716744
73benzene-containing compound metabolic process (GO:0042537)3.82460816
74glycine metabolic process (GO:0006544)3.81551640
75carboxylic acid catabolic process (GO:0046395)3.80785198
76organic acid catabolic process (GO:0016054)3.80785198
77regulation of cholesterol esterification (GO:0010872)3.77857366
78lipid oxidation (GO:0034440)3.77273064
79bile acid and bile salt transport (GO:0015721)3.76362603
80valine metabolic process (GO:0006573)3.75841395
81fatty acid catabolic process (GO:0009062)3.67226647
82exogenous drug catabolic process (GO:0042738)3.66987304
83monocarboxylic acid catabolic process (GO:0072329)3.66564430
84plasma lipoprotein particle clearance (GO:0034381)3.62644307
85serine family amino acid biosynthetic process (GO:0009070)3.61226562
86carnitine metabolic process (GO:0009437)3.58315268
87regulation of cholesterol homeostasis (GO:2000188)3.54625831
88imidazole-containing compound metabolic process (GO:0052803)3.53621751
89positive regulation of lipid catabolic process (GO:0050996)3.53606849
90regulation of bile acid biosynthetic process (GO:0070857)3.52038271
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51822313
92glucuronate metabolic process (GO:0019585)3.51352330
93uronic acid metabolic process (GO:0006063)3.51352330
94phospholipid efflux (GO:0033700)3.50394563
95branched-chain amino acid catabolic process (GO:0009083)3.49277169
96positive regulation of fatty acid beta-oxidation (GO:0032000)3.43660757
97indole-containing compound metabolic process (GO:0042430)3.43207966
98water-soluble vitamin biosynthetic process (GO:0042364)3.42148714
99branched-chain amino acid metabolic process (GO:0009081)3.38884119
100arginine metabolic process (GO:0006525)3.38607166
101phospholipid homeostasis (GO:0055091)3.36862062
102cholesterol efflux (GO:0033344)3.35485063
103negative regulation of lipase activity (GO:0060192)3.35047013
104flavonoid metabolic process (GO:0009812)3.34722135
105piRNA metabolic process (GO:0034587)3.33462484
106drug transport (GO:0015893)3.31043873
107aldehyde catabolic process (GO:0046185)3.29875243
108sulfation (GO:0051923)3.29764149
109gamma-aminobutyric acid transport (GO:0015812)3.26578183
110biotin metabolic process (GO:0006768)3.25694334
111DNA deamination (GO:0045006)3.19880486
112oxidative demethylation (GO:0070989)3.08872046
113primary amino compound metabolic process (GO:1901160)3.06443662
114response to pheromone (GO:0019236)3.03521359
115negative regulation of mast cell activation (GO:0033004)3.01393535
116serotonin metabolic process (GO:0042428)2.99576540
117neural tube formation (GO:0001841)2.99238881
118positive regulation of fatty acid oxidation (GO:0046321)2.98505788
119DNA methylation involved in gamete generation (GO:0043046)2.98487664
120regulation of action potential (GO:0098900)2.97902657
121cAMP catabolic process (GO:0006198)2.97381681
122detection of light stimulus involved in visual perception (GO:0050908)2.94564921
123detection of light stimulus involved in sensory perception (GO:0050962)2.94564921
124regulation of hippo signaling (GO:0035330)2.93168132
125interkinetic nuclear migration (GO:0022027)2.92841504
126neuronal action potential (GO:0019228)2.88144069
127negative regulation of translation, ncRNA-mediated (GO:0040033)2.86609204
128regulation of translation, ncRNA-mediated (GO:0045974)2.86609204
129negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86609204
130epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86196563
131regulation of sequestering of triglyceride (GO:0010889)2.85645465
132somite development (GO:0061053)2.74467996
133mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73377394
134mitochondrial respiratory chain complex I assembly (GO:0032981)2.73377394
135NADH dehydrogenase complex assembly (GO:0010257)2.73377394
136behavioral response to ethanol (GO:0048149)2.71098887
137NAD biosynthetic process (GO:0009435)2.70215077
138platelet dense granule organization (GO:0060155)2.68626511
139positive regulation of fatty acid transport (GO:2000193)2.68059055
140kidney morphogenesis (GO:0060993)2.65912361
141regulation of gene silencing by RNA (GO:0060966)2.64950306
142regulation of posttranscriptional gene silencing (GO:0060147)2.64950306
143regulation of gene silencing by miRNA (GO:0060964)2.64950306
144membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.64576186
145reflex (GO:0060004)2.64460743
146protein K11-linked deubiquitination (GO:0035871)2.63599167
147regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61162399
148negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60700015
149cellular response to ATP (GO:0071318)2.59207730
150synaptic transmission, cholinergic (GO:0007271)2.59129818
151negative regulation of reactive oxygen species metabolic process (GO:2000378)2.58983295
152negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57332195
153cyclic nucleotide catabolic process (GO:0009214)2.57112516
154S-adenosylmethionine metabolic process (GO:0046500)2.55628966
155regulation of mesoderm development (GO:2000380)2.53883199
156rhodopsin mediated signaling pathway (GO:0016056)2.53035733
157L-methionine salvage (GO:0071267)2.50331201
158L-methionine biosynthetic process (GO:0071265)2.50331201
159amino acid salvage (GO:0043102)2.50331201
160spinal cord motor neuron differentiation (GO:0021522)2.49685380
161nonmotile primary cilium assembly (GO:0035058)2.49144386
162preassembly of GPI anchor in ER membrane (GO:0016254)2.49001506
163axoneme assembly (GO:0035082)2.47081332
164regulation of memory T cell differentiation (GO:0043380)2.46886486
165regulation of glucokinase activity (GO:0033131)2.46754614
166regulation of hexokinase activity (GO:1903299)2.46754614
167L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46482046
168multicellular organism reproduction (GO:0032504)2.46280338
169protein polyglutamylation (GO:0018095)2.46241085
170nephron tubule morphogenesis (GO:0072078)2.45938081
171nephron epithelium morphogenesis (GO:0072088)2.45938081
172male meiosis I (GO:0007141)2.45897019
173dopamine transport (GO:0015872)2.44810309
174G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.43883781
175cilium or flagellum-dependent cell motility (GO:0001539)2.42349904
1763-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.42313222
177purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.42313222
178protein complex biogenesis (GO:0070271)2.41656844
179regulation of establishment of cell polarity (GO:2000114)2.41547979
180negative regulation of telomere maintenance (GO:0032205)2.41521588
181protein localization to cilium (GO:0061512)2.40821577
182protein-cofactor linkage (GO:0018065)2.40207472
183methionine biosynthetic process (GO:0009086)2.40156396
184reciprocal DNA recombination (GO:0035825)2.39246274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.27664627
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.15410627
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.78646465
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.49382874
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.07137767
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.66214229
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.78290019
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.73683546
9ZNF274_21170338_ChIP-Seq_K562_Hela3.44893215
10VDR_22108803_ChIP-Seq_LS180_Human3.19805443
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.85158158
12EZH2_22144423_ChIP-Seq_EOC_Human2.68942411
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57515498
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38013445
15IGF1R_20145208_ChIP-Seq_DFB_Human2.33718554
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27751301
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17923643
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.12891895
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.02826046
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2161984
21FUS_26573619_Chip-Seq_HEK293_Human1.98057328
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96767209
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.94525033
24ER_23166858_ChIP-Seq_MCF-7_Human1.93107124
25EWS_26573619_Chip-Seq_HEK293_Human1.87521212
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77765393
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75361109
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67889267
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.67808316
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65338295
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64681698
32STAT3_23295773_ChIP-Seq_U87_Human1.63292131
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.60987467
34IRF1_19129219_ChIP-ChIP_H3396_Human1.60670269
35CLOCK_20551151_ChIP-Seq_293T_Human1.59650276
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57102473
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50837958
38TCF4_23295773_ChIP-Seq_U87_Human1.49172993
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47089491
40GATA1_22025678_ChIP-Seq_K562_Human1.45373995
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.44767065
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43204067
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41099335
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41099335
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40777359
46HTT_18923047_ChIP-ChIP_STHdh_Human1.40349894
47TP53_22573176_ChIP-Seq_HFKS_Human1.39338522
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38338325
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34370615
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33519045
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33216348
52* HNF4A_19822575_ChIP-Seq_HepG2_Human1.32354253
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32349512
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32062915
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.31305144
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30106628
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29602054
58REST_21632747_ChIP-Seq_MESCs_Mouse1.27181333
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.25219919
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.24620595
61NANOG_19829295_ChIP-Seq_ESCs_Human1.23227938
62SOX2_19829295_ChIP-Seq_ESCs_Human1.23227938
63RUNX2_22187159_ChIP-Seq_PCA_Human1.21446813
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20632269
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20510518
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.20092930
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20092930
68* FLI1_21867929_ChIP-Seq_TH2_Mouse1.18916475
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.15624569
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14655812
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13300402
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13217648
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13055213
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.12954336
75TAF15_26573619_Chip-Seq_HEK293_Human1.10459012
76NCOR_22424771_ChIP-Seq_293T_Human1.10429725
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09417231
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.08995697
79RNF2_27304074_Chip-Seq_NSC_Mouse1.08596602
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08463134
81NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07920469
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07920469
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07428382
84TP53_16413492_ChIP-PET_HCT116_Human1.07301499
85ZNF263_19887448_ChIP-Seq_K562_Human1.06409041
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.06093580
87* CRX_20693478_ChIP-Seq_RETINA_Mouse1.05758500
88HOXB7_26014856_ChIP-Seq_BT474_Human1.05650000
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04704174
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04155604
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04128790
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.03451834
93* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01839581
94AHR_22903824_ChIP-Seq_MCF-7_Human1.01520755
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01366539
96AR_20517297_ChIP-Seq_VCAP_Human1.01316826
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00248005
98P53_22387025_ChIP-Seq_ESCs_Mouse0.99335711
99EZH2_27304074_Chip-Seq_ESCs_Mouse0.99299769
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98582513
101MYC_18940864_ChIP-ChIP_HL60_Human0.97737271
102PIAS1_25552417_ChIP-Seq_VCAP_Human0.97355581
103SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96049808
104STAT3_18555785_Chip-Seq_ESCs_Mouse0.95640159
105* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95635248
106SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94806024
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92540265
108GATA4_25053715_ChIP-Seq_YYC3_Human0.91715202
109GBX2_23144817_ChIP-Seq_PC3_Human0.91490752
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88617160
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.88159573
112BCAT_22108803_ChIP-Seq_LS180_Human0.87718416
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87127604
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85337565
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84191704
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83051169
117ESR1_21235772_ChIP-Seq_MCF-7_Human0.82818283
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80762334
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80451248
120RXR_22108803_ChIP-Seq_LS180_Human0.80238291
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80079458
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78918248
123RXRA_24833708_ChIP-Seq_LIVER_Mouse0.76275075
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.74309025
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72419661
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72330435
127FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72176572
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.71906150
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.71418517
130TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.67916213
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.66548437
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.65098572
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.63578013
134KAP1_22055183_ChIP-Seq_ESCs_Mouse0.63276398
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.62897242
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62766542
137AR_21572438_ChIP-Seq_LNCaP_Human0.62720930
138* CBP_21632823_ChIP-Seq_H3396_Human0.62676599
139CDX2_22108803_ChIP-Seq_LS180_Human0.62047411
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.61387363
141IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.59810397
142CTBP1_25329375_ChIP-Seq_LNCAP_Human0.58698071
143FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57852187
144EGR1_19032775_ChIP-ChIP_M12_Human0.57312228
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.57282253
146AR_25329375_ChIP-Seq_VCAP_Human0.57123687
147GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.56760705
148CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.56535115
149SMAD4_21799915_ChIP-Seq_A2780_Human0.56329559
150SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.55180709
151* STAT1_17558387_ChIP-Seq_HELA_Human0.54781743
152* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.54592772
153PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53938450
154GATA2_19941826_ChIP-Seq_K562_Human0.53631897
155NR3C1_21868756_ChIP-Seq_MCF10A_Human0.53462604
156SOX2_20726797_ChIP-Seq_SW620_Human0.53043375
157SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.52948033
158NR3C1_23031785_ChIP-Seq_PC12_Mouse0.52624367
159P300_19829295_ChIP-Seq_ESCs_Human0.52093808
160TP63_23658742_ChIP-Seq_EP156T_Human0.51854296
161MTF2_20144788_ChIP-Seq_MESCs_Mouse0.51748149
162TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.50967604
163BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.50760365
164SMAD4_21741376_ChIP-Seq_EPCs_Human0.50371045
165IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.50161932
166CBP_20019798_ChIP-Seq_JUKART_Human0.50161932
167UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.49961238
168SOX2_21211035_ChIP-Seq_LN229_Gbm0.49899411
169EP300_21415370_ChIP-Seq_HL-1_Mouse0.48776021
170TCF4_22108803_ChIP-Seq_LS180_Human0.48632526
171CEBPB_22108803_ChIP-Seq_LS180_Human0.48619334
172PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48584510
173GATA1_19941826_ChIP-Seq_K562_Human0.48481377
174RAD21_21589869_ChIP-Seq_MESCs_Mouse0.48471821
175* CDX2_20551321_ChIP-Seq_CACO-2_Human0.48217880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.86203489
2MP0005360_urolithiasis7.35304164
3MP0005085_abnormal_gallbladder_physiolo5.96902108
4MP0005365_abnormal_bile_salt5.89373743
5MP0008875_abnormal_xenobiotic_pharmacok4.73839522
6MP0003806_abnormal_nucleotide_metabolis3.68819202
7MP0003252_abnormal_bile_duct3.59943485
8MP0010329_abnormal_lipoprotein_level3.34913219
9MP0005332_abnormal_amino_acid3.19387918
10MP0000569_abnormal_digit_pigmentation3.09070762
11MP0003195_calcinosis3.00612584
12MP0005083_abnormal_biliary_tract2.88265943
13MP0001666_abnormal_nutrient_absorption2.72682949
14MP0005551_abnormal_eye_electrophysiolog2.44628970
15MP0004019_abnormal_vitamin_homeostasis2.44038418
16MP0003136_yellow_coat_color2.29631551
17MP0009840_abnormal_foam_cell2.27453470
18MP0002118_abnormal_lipid_homeostasis2.21122275
19MP0008877_abnormal_DNA_methylation2.14291053
20MP0001968_abnormal_touch/_nociception2.04519195
21MP0001501_abnormal_sleep_pattern2.03833897
22MP0003191_abnormal_cellular_cholesterol1.99360965
23MP0000427_abnormal_hair_cycle1.98958771
24MP0000609_abnormal_liver_physiology1.97623585
25MP0002138_abnormal_hepatobiliary_system1.96048437
26MP0002102_abnormal_ear_morphology1.95807085
27MP0009745_abnormal_behavioral_response1.88327740
28MP0002638_abnormal_pupillary_reflex1.85878871
29MP0001986_abnormal_taste_sensitivity1.85586065
30MP0004885_abnormal_endolymph1.83211366
31MP0003868_abnormal_feces_composition1.81872974
32MP0005319_abnormal_enzyme/_coenzyme1.79608130
33MP0002653_abnormal_ependyma_morphology1.77197918
34MP0009046_muscle_twitch1.76818950
35MP0001485_abnormal_pinna_reflex1.75132882
36MP0002736_abnormal_nociception_after1.70921324
37MP0004142_abnormal_muscle_tone1.68214726
38MP0005584_abnormal_enzyme/coenzyme_acti1.64070103
39MP0009643_abnormal_urine_homeostasis1.63427156
40MP0005451_abnormal_body_composition1.62376254
41MP0002272_abnormal_nervous_system1.60100973
42MP0005174_abnormal_tail_pigmentation1.58938244
43MP0001764_abnormal_homeostasis1.57231679
44MP0006292_abnormal_olfactory_placode1.55204722
45MP0004145_abnormal_muscle_electrophysio1.46798858
46MP0000631_abnormal_neuroendocrine_gland1.42633501
47MP0004130_abnormal_muscle_cell1.39518694
48MP0005253_abnormal_eye_physiology1.39256052
49MP0006276_abnormal_autonomic_nervous1.38484135
50MP0006072_abnormal_retinal_apoptosis1.36831431
51MP0002160_abnormal_reproductive_system1.36818538
52MP0010386_abnormal_urinary_bladder1.36085310
53MP0000383_abnormal_hair_follicle1.33245623
54MP0004133_heterotaxia1.33175240
55MP0002735_abnormal_chemical_nociception1.32550970
56MP0004215_abnormal_myocardial_fiber1.32072707
57MP0002938_white_spotting1.31007399
58MP0004043_abnormal_pH_regulation1.30539464
59MP0005645_abnormal_hypothalamus_physiol1.28909452
60MP0005636_abnormal_mineral_homeostasis1.27514825
61MP0001486_abnormal_startle_reflex1.25224917
62MP0003186_abnormal_redox_activity1.23190859
63MP0002876_abnormal_thyroid_physiology1.23106422
64MP0002064_seizures1.21350122
65MP0002837_dystrophic_cardiac_calcinosis1.20521638
66MP0005389_reproductive_system_phenotype1.19032985
67MP0005535_abnormal_body_temperature1.16192690
68MP0000372_irregular_coat_pigmentation1.15199211
69MP0003656_abnormal_erythrocyte_physiolo1.14676361
70MP0002572_abnormal_emotion/affect_behav1.14537015
71MP0005670_abnormal_white_adipose1.12307019
72MP0005084_abnormal_gallbladder_morpholo1.10993825
73MP0003890_abnormal_embryonic-extraembry1.08687287
74MP0005647_abnormal_sex_gland1.08653652
75MP0003283_abnormal_digestive_organ1.08652805
76MP0005386_behavior/neurological_phenoty1.07035390
77MP0004924_abnormal_behavior1.07035390
78MP0006036_abnormal_mitochondrial_physio1.07027240
79MP0009697_abnormal_copulation1.06164524
80MP0002733_abnormal_thermal_nociception1.05759887
81MP0000604_amyloidosis1.05237475
82MP0005171_absent_coat_pigmentation1.05149324
83MP0003787_abnormal_imprinting1.04109049
84MP0001970_abnormal_pain_threshold1.02293812
85MP0002067_abnormal_sensory_capabilities1.00632200
86MP0002557_abnormal_social/conspecific_i1.00309097
87MP0005379_endocrine/exocrine_gland_phen0.99903025
88MP0002971_abnormal_brown_adipose0.99096188
89MP0002078_abnormal_glucose_homeostasis0.98364871
90MP0005195_abnormal_posterior_eye0.97947550
91MP0004742_abnormal_vestibular_system0.97777328
92MP0003329_amyloid_beta_deposits0.97422112
93MP0000598_abnormal_liver_morphology0.96727681
94MP0003137_abnormal_impulse_conducting0.96237251
95MP0003011_delayed_dark_adaptation0.95105191
96MP0001756_abnormal_urination0.94472809
97MP0009764_decreased_sensitivity_to0.93376945
98MP0005377_hearing/vestibular/ear_phenot0.93270725
99MP0003878_abnormal_ear_physiology0.93270725
100MP0002822_catalepsy0.92133772
101MP0001919_abnormal_reproductive_system0.91819396
102MP0005666_abnormal_adipose_tissue0.90718119
103MP0001984_abnormal_olfaction0.89309041
104MP0000647_abnormal_sebaceous_gland0.88550362
105MP0002234_abnormal_pharynx_morphology0.87812367
106MP0003690_abnormal_glial_cell0.87761001
107MP0003880_abnormal_central_pattern0.87697282
108MP0008775_abnormal_heart_ventricle0.87406379
109MP0002063_abnormal_learning/memory/cond0.87092110
110MP0001765_abnormal_ion_homeostasis0.86192903
111MP0003879_abnormal_hair_cell0.85274084
112MP0009642_abnormal_blood_homeostasis0.85083210
113MP0000026_abnormal_inner_ear0.84696090
114MP0001661_extended_life_span0.83925311
115MP0002095_abnormal_skin_pigmentation0.82391982
116MP0005334_abnormal_fat_pad0.82244414
117MP0003635_abnormal_synaptic_transmissio0.81426220
118MP0005220_abnormal_exocrine_pancreas0.79952726
119MP0001502_abnormal_circadian_rhythm0.79888364
120MP0005187_abnormal_penis_morphology0.79499476
121MP0005408_hypopigmentation0.77044045
122MP0009763_increased_sensitivity_to0.77023304
123MP0005410_abnormal_fertilization0.76665439
124MP0004085_abnormal_heartbeat0.75646170
125MP0005423_abnormal_somatic_nervous0.74496744
126MP0003698_abnormal_male_reproductive0.72880878
127MP0002229_neurodegeneration0.72750407
128MP0002136_abnormal_kidney_physiology0.72073412
129MP0003705_abnormal_hypodermis_morpholog0.71529590
130MP0008469_abnormal_protein_level0.71105482
131MP0005376_homeostasis/metabolism_phenot0.70044765
132MP0010234_abnormal_vibrissa_follicle0.69423385
133MP0004185_abnormal_adipocyte_glucose0.67657235
134MP0010368_abnormal_lymphatic_system0.67596751
135MP0009765_abnormal_xenobiotic_induced0.64623237
136MP0000230_abnormal_systemic_arterial0.60890747
137MP0006035_abnormal_mitochondrial_morpho0.60285227
138MP0005448_abnormal_energy_balance0.59755599
139MP0004147_increased_porphyrin_level0.59328643
140MP0008874_decreased_physiological_sensi0.58589530
141MP0002254_reproductive_system_inflammat0.57112258
142MP0003953_abnormal_hormone_level0.56066533
143MP0003638_abnormal_response/metabolism_0.55335729
144MP0003646_muscle_fatigue0.54107098
145MP0005395_other_phenotype0.53886585
146MP0005266_abnormal_metabolism0.53392168
147MP0009780_abnormal_chondrocyte_physiolo0.52127280
148MP0003075_altered_response_to0.51479163
149MP0001881_abnormal_mammary_gland0.50808773
150MP0000639_abnormal_adrenal_gland0.50493980
151MP0002168_other_aberrant_phenotype0.49623181
152MP0009384_cardiac_valve_regurgitation0.49288221
153MP0002928_abnormal_bile_duct0.47322386
154MP0005646_abnormal_pituitary_gland0.47198693
155MP0005166_decreased_susceptibility_to0.46466170
156MP0004782_abnormal_surfactant_physiolog0.43893588
157MP0008961_abnormal_basal_metabolism0.43421080
158MP0005375_adipose_tissue_phenotype0.43051497
159MP0009115_abnormal_fat_cell0.42280505
160MP0000538_abnormal_urinary_bladder0.40470907
161MP0003633_abnormal_nervous_system0.40331352
162MP0003718_maternal_effect0.39924376
163MP0003724_increased_susceptibility_to0.39040700
164MP0005167_abnormal_blood-brain_barrier0.38934175
165MP0005058_abnormal_lysosome_morphology0.38375315
166MP0008872_abnormal_physiological_respon0.37789863
167MP0001944_abnormal_pancreas_morphology0.35857831
168MP0002796_impaired_skin_barrier0.34032335
169MP0001177_atelectasis0.33868677
170MP0005595_abnormal_vascular_smooth0.32894198
171MP0003959_abnormal_lean_body0.31567584
172MP0002970_abnormal_white_adipose0.30946892

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.46419942
2Intrahepatic cholestasis (HP:0001406)6.28313133
3Deep venous thrombosis (HP:0002625)6.13688660
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.54064076
5Xanthomatosis (HP:0000991)5.41303470
6Prolonged partial thromboplastin time (HP:0003645)5.23323406
7Hypobetalipoproteinemia (HP:0003563)5.00123921
8Hyperglycinuria (HP:0003108)4.89485691
9Hyperlipoproteinemia (HP:0010980)4.77570205
10Pancreatic cysts (HP:0001737)4.77354732
11Hyperglycinemia (HP:0002154)4.76452722
12Ketosis (HP:0001946)4.68292069
13Hyperammonemia (HP:0001987)4.59846998
14Abnormality of serine family amino acid metabolism (HP:0010894)4.59317511
15Abnormality of glycine metabolism (HP:0010895)4.59317511
16Complement deficiency (HP:0004431)4.48378058
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.33382997
18Hypoglycemic coma (HP:0001325)4.15854530
19Abnormality of midbrain morphology (HP:0002418)4.10373741
20Molar tooth sign on MRI (HP:0002419)4.10373741
21Pancreatic fibrosis (HP:0100732)4.08159965
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.04876235
23Nephronophthisis (HP:0000090)4.03957754
24Epidermoid cyst (HP:0200040)3.96508911
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.96322431
26Ketoacidosis (HP:0001993)3.93711360
27Hypolipoproteinemia (HP:0010981)3.91464398
28Gout (HP:0001997)3.90917355
29True hermaphroditism (HP:0010459)3.90128461
30Joint hemorrhage (HP:0005261)3.81523934
31Congenital stationary night blindness (HP:0007642)3.77637807
32Abnormality of fatty-acid metabolism (HP:0004359)3.77435003
33Abnormality of the common coagulation pathway (HP:0010990)3.71187502
34Abnormality of methionine metabolism (HP:0010901)3.65501265
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.64324295
36Fat malabsorption (HP:0002630)3.63972039
37Abnormality of alanine metabolism (HP:0010916)3.63496192
38Hyperalaninemia (HP:0003348)3.63496192
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.63496192
40Hypoalphalipoproteinemia (HP:0003233)3.60202537
41Genetic anticipation (HP:0003743)3.52052681
42Abnormality of the renal medulla (HP:0100957)3.47587900
43Abnormality of purine metabolism (HP:0004352)3.46606354
44Conjugated hyperbilirubinemia (HP:0002908)3.39378478
45Abnormality of the renal cortex (HP:0011035)3.34481459
46Type II lissencephaly (HP:0007260)3.31593626
47Progressive cerebellar ataxia (HP:0002073)3.28944432
48Abnormality of nucleobase metabolism (HP:0010932)3.27760125
49Chronic hepatic failure (HP:0100626)3.25887617
50Delayed CNS myelination (HP:0002188)3.22770066
51Tubular atrophy (HP:0000092)3.22471489
52Abnormality of serum amino acid levels (HP:0003112)3.19429548
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.18591543
54Abnormality of the intrinsic pathway (HP:0010989)3.17994653
55Abnormality of complement system (HP:0005339)3.08367014
56Metabolic acidosis (HP:0001942)3.02705055
57Dicarboxylic aciduria (HP:0003215)2.97660328
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97660328
59Generalized aminoaciduria (HP:0002909)2.92662323
60Hypercholesterolemia (HP:0003124)2.92168581
61Inability to walk (HP:0002540)2.91685455
62Pendular nystagmus (HP:0012043)2.91370037
63Abnormality of pyrimidine metabolism (HP:0004353)2.90067667
64Hyperbilirubinemia (HP:0002904)2.88626311
65Gaze-evoked nystagmus (HP:0000640)2.85736423
66Abnormal drinking behavior (HP:0030082)2.85443803
67Polydipsia (HP:0001959)2.85443803
68Steatorrhea (HP:0002570)2.82551591
69Hyperuricemia (HP:0002149)2.79081399
70Increased purine levels (HP:0004368)2.79081399
71Cystic liver disease (HP:0006706)2.78613715
72Attenuation of retinal blood vessels (HP:0007843)2.77116207
73Vascular calcification (HP:0004934)2.77060222
74Lethargy (HP:0001254)2.73938174
75Large for gestational age (HP:0001520)2.68721714
76Abolished electroretinogram (ERG) (HP:0000550)2.64898443
77Congenital, generalized hypertrichosis (HP:0004540)2.60955530
78Decreased circulating renin level (HP:0003351)2.60724932
79Hepatocellular carcinoma (HP:0001402)2.60296618
80Progressive inability to walk (HP:0002505)2.60254594
81Proximal tubulopathy (HP:0000114)2.58173816
82Furrowed tongue (HP:0000221)2.58086462
83Chorioretinal atrophy (HP:0000533)2.53569626
84Medial flaring of the eyebrow (HP:0010747)2.52522541
85Hypochromic microcytic anemia (HP:0004840)2.50422992
86Sensorimotor neuropathy (HP:0007141)2.50165061
87Alkalosis (HP:0001948)2.50153314
88Hypoglycemic seizures (HP:0002173)2.48783498
89Myocardial infarction (HP:0001658)2.48445854
90Birth length less than 3rd percentile (HP:0003561)2.47011347
91Clumsiness (HP:0002312)2.46808102
92Skin nodule (HP:0200036)2.46774379
93Spontaneous abortion (HP:0005268)2.43929873
94Cardiovascular calcification (HP:0011915)2.43709590
95Keratoconus (HP:0000563)2.42419686
96Increased corneal curvature (HP:0100692)2.42419686
97Protruding tongue (HP:0010808)2.38895118
98Cerebellar dysplasia (HP:0007033)2.36029830
99Cerebral edema (HP:0002181)2.35880744
100Abnormality of proline metabolism (HP:0010907)2.35239110
101Hydroxyprolinuria (HP:0003080)2.35239110
102Sclerocornea (HP:0000647)2.34652409
103Irritability (HP:0000737)2.33868624
104Dynein arm defect of respiratory motile cilia (HP:0012255)2.33310404
105Absent/shortened dynein arms (HP:0200106)2.33310404
106Vomiting (HP:0002013)2.32822274
107Concave nail (HP:0001598)2.29984737
108Pancreatitis (HP:0001733)2.29630740
109Spastic diplegia (HP:0001264)2.29089370
110Systemic lupus erythematosus (HP:0002725)2.27925130
111Neonatal onset (HP:0003623)2.26161615
112Malnutrition (HP:0004395)2.23872809
113Abnormal rod and cone electroretinograms (HP:0008323)2.23079250
114Renal cortical cysts (HP:0000803)2.22568600
115Congenital hepatic fibrosis (HP:0002612)2.21204234
116Glycosuria (HP:0003076)2.20603288
117Abnormality of urine glucose concentration (HP:0011016)2.20603288
118Acanthocytosis (HP:0001927)2.17637249
119Aplasia/Hypoplasia of the tibia (HP:0005772)2.16941926
120Abnormality of the pons (HP:0007361)2.15135103
121Polyuria (HP:0000103)2.13902594
122Decreased central vision (HP:0007663)2.12984687
123Hyperventilation (HP:0002883)2.12813065
124Febrile seizures (HP:0002373)2.12525617
125Aplasia/Hypoplasia of the tongue (HP:0010295)2.12232749
126Brushfield spots (HP:0001088)2.12020242
127Abnormality of the renal collecting system (HP:0004742)2.11645957
128Broad-based gait (HP:0002136)2.10969179
129Rickets (HP:0002748)2.09944187
130Abnormal biliary tract physiology (HP:0012439)2.09697615
131Bile duct proliferation (HP:0001408)2.09697615
132Male pseudohermaphroditism (HP:0000037)2.08466992
133Abnormal gallbladder morphology (HP:0012437)2.08317186
134Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07144635
135Patellar aplasia (HP:0006443)2.05210227
136Enlarged kidneys (HP:0000105)2.04407022
137Congenital sensorineural hearing impairment (HP:0008527)2.03724598
138Lissencephaly (HP:0001339)2.02889046
139Anencephaly (HP:0002323)2.02459991
140Hypoplasia of the pons (HP:0012110)2.01906251
141Cholelithiasis (HP:0001081)2.01876348
142Stomach cancer (HP:0012126)1.99990323
143Hyperinsulinemic hypoglycemia (HP:0000825)1.99552824
144Generalized hypopigmentation of hair (HP:0011358)1.99170153
145Esophageal varix (HP:0002040)1.97604844
146Aplasia/Hypoplasia of the patella (HP:0006498)1.97124206
147Mitral stenosis (HP:0001718)1.95649001
148Late onset (HP:0003584)1.95456499
149Status epilepticus (HP:0002133)1.93891995
150Cholecystitis (HP:0001082)1.93422970
151Abnormal gallbladder physiology (HP:0012438)1.93422970
152Amelogenesis imperfecta (HP:0000705)1.93328209
153Tachypnea (HP:0002789)1.92858118
154Hyperglycemia (HP:0003074)1.92331101
155Bony spicule pigmentary retinopathy (HP:0007737)1.90410463
156Duplicated collecting system (HP:0000081)1.89827616
157Gait imbalance (HP:0002141)1.89313838
158Severe muscular hypotonia (HP:0006829)1.87524003
159Hypophosphatemic rickets (HP:0004912)1.87386478
160Abnormal cartilage morphology (HP:0002763)1.85591520
161Nausea (HP:0002018)1.83588325
162Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81455764
163Confusion (HP:0001289)1.80970709
164Fair hair (HP:0002286)1.79984267
165Pachygyria (HP:0001302)1.79977339
166Postaxial foot polydactyly (HP:0001830)1.79760539
167Amyloidosis (HP:0011034)1.79573457
168Hemiparesis (HP:0001269)1.78967014
169Congenital primary aphakia (HP:0007707)1.78047884
170Acute hepatic failure (HP:0006554)1.77770710
171Abnormality of vitamin metabolism (HP:0100508)1.76164090
172Hypothermia (HP:0002045)1.75968050
173Abnormal enzyme/coenzyme activity (HP:0012379)1.75655751
174Glomerulonephritis (HP:0000099)1.75621884
175Dialeptic seizures (HP:0011146)1.75501184
176Abnormal urine output (HP:0012590)1.75442523
177Nephrolithiasis (HP:0000787)1.72505516
178Aplasia/Hypoplasia of the uvula (HP:0010293)1.72496292
179Methylmalonic aciduria (HP:0012120)1.72289432
180Occipital encephalocele (HP:0002085)1.67766508
181Abnormality of macular pigmentation (HP:0008002)1.66079157
182Focal seizures (HP:0007359)1.65723528
183Absent speech (HP:0001344)1.65195103
184Nephrogenic diabetes insipidus (HP:0009806)1.64603384
185Optic nerve hypoplasia (HP:0000609)1.63786309
186Bilateral microphthalmos (HP:0007633)1.62708624
187Genital tract atresia (HP:0001827)1.62412404
188Short hallux (HP:0010109)1.60772361
189Absent rod-and cone-mediated responses on ERG (HP:0007688)1.60055659
190Methylmalonic acidemia (HP:0002912)1.58784596
191Focal motor seizures (HP:0011153)1.57171922
192Bulbous nose (HP:0000414)1.56282481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.35810061
2ACVR1B3.93539030
3BMPR1B3.44330982
4SIK13.41792021
5ADRBK23.21639973
6INSRR2.79625195
7EPHA42.73291264
8MAP2K42.59349016
9GRK12.56664962
10FGFR42.56291051
11TAOK32.56043462
12ERN12.52041075
13ZAK2.51424603
14FRK2.33917294
15TLK12.32136958
16LATS12.20655727
17ERBB42.18989551
18OXSR12.14490264
19TRIB31.99424731
20WNK41.85743941
21WNK31.85043456
22MAP4K21.82140369
23NUAK11.79926334
24DAPK21.77043586
25CASK1.76136765
26MAPK131.71379595
27MST1R1.62791964
28STK38L1.50828723
29PKN21.50642695
30PINK11.47546767
31FGFR21.42434159
32ABL21.41590285
33PDK31.36128019
34PDK41.36128019
35TIE11.36002271
36MAPK111.32955964
37ADRBK11.31905229
38SGK21.30480550
39PNCK1.29527247
40TXK1.28437806
41CAMKK21.28157787
42MKNK21.27335153
43SGK31.24561965
44PRKAA21.24448089
45TGFBR11.22768064
46PIK3CG1.19869227
47BRSK21.16591614
48SGK2231.16569855
49SGK4941.16569855
50MAP3K41.13891384
51TNIK1.12735679
52MAP2K11.10777852
53KSR21.10203589
54MAPK151.09925559
55MAP3K71.06299733
56PHKG11.03138140
57PHKG21.03138140
58MAP3K21.01311870
59MAPKAPK30.97815602
60PDPK10.97555924
61JAK20.96759142
62MAP2K30.95458060
63LATS20.90447339
64MARK10.89382114
65MAP3K30.88889957
66NLK0.87214753
67PRKCE0.86228404
68TGFBR20.84641566
69PRKAA10.83426206
70WEE10.83118726
71PRKCZ0.81465862
72STK380.80582148
73MAP2K60.79785956
74RET0.78793697
75NTRK30.78332080
76STK390.78049011
77MAPK120.77991518
78PDK10.77679589
79NEK90.75008137
80ARAF0.74518430
81FLT30.74121663
82PTK60.73860889
83OBSCN0.73103875
84CAMK1D0.72732976
85PRKACG0.71307060
86CAMK2G0.71209421
87PDK20.70560235
88PTK2B0.69555807
89DYRK20.69356049
90TEC0.68717854
91MAP3K60.68221279
92MUSK0.67599467
93MAP3K90.67565828
94JAK10.67490328
95STK110.67199331
96TRPM70.64085669
97AKT30.63709952
98MAPK40.62863604
99FGFR30.61940266
100TAOK10.61464403
101MET0.61266259
102NTRK10.60711112
103CAMK1G0.59981405
104GSK3A0.57746631
105MAP2K70.56525659
106PRKCQ0.56360945
107MAP3K130.56064684
108PRKCG0.55888463
109TAF10.55381854
110CAMK10.53841096
111RPS6KA50.52890152
112IKBKB0.52729718
113TYK20.52647815
114MAP3K50.51223607
115CAMKK10.50420153
116PAK30.50271271
117PKN10.48158465
118CHUK0.47713993
119RPS6KA60.47486225
120ERBB30.47052758
121MAPK70.46929684
122GRK60.46262070
123RIPK10.45086817
124PTK20.44675772
125PRKACA0.43009426
126WNK10.42928611
127IGF1R0.42905479
128VRK10.42776620
129CAMK2A0.42333255
130BMPR20.42152563
131MAP3K10.41893345
132GRK70.41338301
133CSNK1G20.40008013
134IRAK30.38981095
135NTRK20.38288900
136MAPKAPK50.38140380
137TNK20.38110318
138PRKG10.37518947
139EPHA30.37470749
140SGK10.37369611
141KIT0.37227531
142PRKCH0.37104619
143NEK20.36931056
144IRAK20.36569001
145TRIM280.36233178
146PAK60.35326241
147CSNK1A10.34539274
148CSNK1D0.34389644
149GRK50.34271772
150IRAK10.34052341
151RIPK40.33424394
152MAP2K20.32653268
153PIK3CA0.32431041
154MINK10.31984257
155RAF10.31978765
156KDR0.31898903
157STK30.31857458
158CDK60.31518754
159FER0.31257409
160PRKCA0.29958888
161ERBB20.28844164
162CAMK40.28337569
163MKNK10.28210990

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.02044697
2Nitrogen metabolism_Homo sapiens_hsa009103.51514254
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.15411998
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.11934893
5Arginine biosynthesis_Homo sapiens_hsa002202.86307447
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.83855749
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.76048408
8Fatty acid degradation_Homo sapiens_hsa000712.68154044
9Tryptophan metabolism_Homo sapiens_hsa003802.60265416
10Phototransduction_Homo sapiens_hsa047442.53901184
11Butanoate metabolism_Homo sapiens_hsa006502.52318877
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52300902
13Propanoate metabolism_Homo sapiens_hsa006402.48330074
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.37377740
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.33124389
16Complement and coagulation cascades_Homo sapiens_hsa046102.18136416
17Peroxisome_Homo sapiens_hsa041462.16465179
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15965291
19Fatty acid metabolism_Homo sapiens_hsa012122.04797200
20PPAR signaling pathway_Homo sapiens_hsa033201.99279015
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90429434
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89182102
23Nicotine addiction_Homo sapiens_hsa050331.89168759
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87827288
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87303554
26beta-Alanine metabolism_Homo sapiens_hsa004101.84931695
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77607590
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72640696
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70835438
30Histidine metabolism_Homo sapiens_hsa003401.68902180
31Ether lipid metabolism_Homo sapiens_hsa005651.67244864
32Chemical carcinogenesis_Homo sapiens_hsa052041.62391012
33Pyruvate metabolism_Homo sapiens_hsa006201.62009332
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61969669
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.60462848
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58988763
37Bile secretion_Homo sapiens_hsa049761.57442236
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56485387
39Caffeine metabolism_Homo sapiens_hsa002321.55427043
40Phenylalanine metabolism_Homo sapiens_hsa003601.48292884
41Homologous recombination_Homo sapiens_hsa034401.43701669
42Sulfur metabolism_Homo sapiens_hsa009201.43425885
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.42096374
44Retinol metabolism_Homo sapiens_hsa008301.41895342
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37374228
46Taste transduction_Homo sapiens_hsa047421.36024684
47Fanconi anemia pathway_Homo sapiens_hsa034601.33177257
48Morphine addiction_Homo sapiens_hsa050321.33038000
49Olfactory transduction_Homo sapiens_hsa047401.31612841
50Fatty acid elongation_Homo sapiens_hsa000621.30971169
51Oxidative phosphorylation_Homo sapiens_hsa001901.30942822
52Selenocompound metabolism_Homo sapiens_hsa004501.30166743
53Staphylococcus aureus infection_Homo sapiens_hsa051501.29111637
54Carbon metabolism_Homo sapiens_hsa012001.27929759
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26401522
56Starch and sucrose metabolism_Homo sapiens_hsa005001.25952226
57Tyrosine metabolism_Homo sapiens_hsa003501.24821450
58Basal transcription factors_Homo sapiens_hsa030221.21926755
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20923787
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20553530
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.16115099
62RNA polymerase_Homo sapiens_hsa030201.13915631
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.13859242
64Arachidonic acid metabolism_Homo sapiens_hsa005901.12836359
65Vitamin B6 metabolism_Homo sapiens_hsa007501.12575117
66Biosynthesis of amino acids_Homo sapiens_hsa012301.09651682
67Fat digestion and absorption_Homo sapiens_hsa049751.08336957
68Folate biosynthesis_Homo sapiens_hsa007901.06549701
69ABC transporters_Homo sapiens_hsa020101.04249498
70Arginine and proline metabolism_Homo sapiens_hsa003300.97461287
71Vitamin digestion and absorption_Homo sapiens_hsa049770.96674904
72Steroid biosynthesis_Homo sapiens_hsa001000.95031232
73Serotonergic synapse_Homo sapiens_hsa047260.93972427
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92170359
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.91072933
76Circadian entrainment_Homo sapiens_hsa047130.90886188
77Glycerolipid metabolism_Homo sapiens_hsa005610.90483456
78Fatty acid biosynthesis_Homo sapiens_hsa000610.88411286
79Dorso-ventral axis formation_Homo sapiens_hsa043200.85572054
80Glutamatergic synapse_Homo sapiens_hsa047240.85402753
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84710628
82Lysine degradation_Homo sapiens_hsa003100.80252536
83Calcium signaling pathway_Homo sapiens_hsa040200.77954566
84Parkinsons disease_Homo sapiens_hsa050120.77908777
85Cardiac muscle contraction_Homo sapiens_hsa042600.76988880
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.76441761
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.74652641
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70136689
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69331575
90Salivary secretion_Homo sapiens_hsa049700.68435024
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63999652
92Protein export_Homo sapiens_hsa030600.62801470
93Glutathione metabolism_Homo sapiens_hsa004800.62184708
94Sulfur relay system_Homo sapiens_hsa041220.61685988
95RNA degradation_Homo sapiens_hsa030180.59771162
96Collecting duct acid secretion_Homo sapiens_hsa049660.56608581
97Huntingtons disease_Homo sapiens_hsa050160.54958829
98Alzheimers disease_Homo sapiens_hsa050100.51553944
99Pentose phosphate pathway_Homo sapiens_hsa000300.50138518
100Metabolic pathways_Homo sapiens_hsa011000.45608448
101cAMP signaling pathway_Homo sapiens_hsa040240.43329200
102Purine metabolism_Homo sapiens_hsa002300.39272296
103Cocaine addiction_Homo sapiens_hsa050300.39204116
104Cholinergic synapse_Homo sapiens_hsa047250.38882378
105Long-term depression_Homo sapiens_hsa047300.37709728
106Dopaminergic synapse_Homo sapiens_hsa047280.36842979
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.36768291
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35949723
109Renin secretion_Homo sapiens_hsa049240.35203939
110Insulin resistance_Homo sapiens_hsa049310.34615818
111Gastric acid secretion_Homo sapiens_hsa049710.34065291
112Oxytocin signaling pathway_Homo sapiens_hsa049210.33343903
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31401864
114Glucagon signaling pathway_Homo sapiens_hsa049220.28511796
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.26832512
116Prion diseases_Homo sapiens_hsa050200.21695107
117Linoleic acid metabolism_Homo sapiens_hsa005910.18967292
118Fructose and mannose metabolism_Homo sapiens_hsa000510.16681947
119AMPK signaling pathway_Homo sapiens_hsa041520.16582136
120One carbon pool by folate_Homo sapiens_hsa006700.14841709
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13103765
122Galactose metabolism_Homo sapiens_hsa000520.08485415
123Thyroid hormone synthesis_Homo sapiens_hsa049180.05683761
124Insulin signaling pathway_Homo sapiens_hsa049100.04093327
125Ovarian steroidogenesis_Homo sapiens_hsa049130.02930464
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.02197131
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02117244
128Regulation of autophagy_Homo sapiens_hsa041400.01904812
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.00613903
130Insulin secretion_Homo sapiens_hsa04911-0.1373605
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.1271285
132Circadian rhythm_Homo sapiens_hsa04710-0.1257786
133Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.1070362
134Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1052898
135GABAergic synapse_Homo sapiens_hsa04727-0.0952489
136Mineral absorption_Homo sapiens_hsa04978-0.0876180
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0777418
138Renin-angiotensin system_Homo sapiens_hsa04614-0.0718280
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0699281
140Pancreatic secretion_Homo sapiens_hsa04972-0.0657951
141Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0435616
142Protein digestion and absorption_Homo sapiens_hsa04974-0.0305505
143Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0270704
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0206558

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »