ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-amino acid import (GO:0043092)	5.64165397
2	cellular potassium ion homeostasis (GO:0030007)	5.53252635
3	L-phenylalanine catabolic process (GO:0006559)	5.51454977
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.51454977
5	amino acid import (GO:0043090)	5.37085298
6	sodium ion export (GO:0071436)	5.35925412
7	gamma-aminobutyric acid transport (GO:0015812)	5.24363206
8	cell communication by electrical coupling (GO:0010644)	5.04174925
9	exogenous drug catabolic process (GO:0042738)	4.98747425
10	complement activation, alternative pathway (GO:0006957)	4.93798293
11	L-phenylalanine metabolic process (GO:0006558)	4.90508684
12	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.90508684
13	locomotory exploration behavior (GO:0035641)	4.88415204
14	drug catabolic process (GO:0042737)	4.76055271
15	negative regulation of astrocyte differentiation (GO:0048712)	4.70952850
16	alanine transport (GO:0032328)	4.69466477
17	neurotransmitter-gated ion channel clustering (GO:0072578)	4.64062510
18	glyoxylate metabolic process (GO:0046487)	4.63689030
19	C4-dicarboxylate transport (GO:0015740)	4.58718291
20	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.55316217
21	omega-hydroxylase P450 pathway (GO:0097267)	4.52959717
22	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	4.48952867
23	regulation of protein activation cascade (GO:2000257)	4.47273037
24	epoxygenase P450 pathway (GO:0019373)	4.46187379
25	neurotransmitter uptake (GO:0001504)	4.35033056
26	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	4.34021422
27	regulation of fibrinolysis (GO:0051917)	4.28180205
28	regulation of complement activation (GO:0030449)	4.20431969
29	cellular sodium ion homeostasis (GO:0006883)	4.15807432
30	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.11434791
31	potassium ion import (GO:0010107)	4.10778372
32	negative regulation of fibrinolysis (GO:0051918)	4.08505370
33	axon ensheathment in central nervous system (GO:0032291)	4.04222646
34	central nervous system myelination (GO:0022010)	4.04222646
35	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.96927800
36	response to auditory stimulus (GO:0010996)	3.92149154
37	synaptic vesicle maturation (GO:0016188)	3.89834575
38	negative regulation of sodium ion transport (GO:0010766)	3.87202882
39	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.87098169
40	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.86406584
41	synaptic vesicle exocytosis (GO:0016079)	3.81212216
42	negative regulation of sterol transport (GO:0032372)	3.77902220
43	negative regulation of cholesterol transport (GO:0032375)	3.77902220
44	neuron cell-cell adhesion (GO:0007158)	3.77646697
45	ethanol oxidation (GO:0006069)	3.76772224
46	regulation of beta-amyloid formation (GO:1902003)	3.76172808
47	glutamate secretion (GO:0014047)	3.75221085
48	low-density lipoprotein particle remodeling (GO:0034374)	3.74672621
49	potassium ion homeostasis (GO:0055075)	3.74072878
50	glutamate metabolic process (GO:0006536)	3.73897321
51	serine family amino acid catabolic process (GO:0009071)	3.73774385
52	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.72638087
53	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.71155969
54	vocalization behavior (GO:0071625)	3.70623933
55	atrial cardiac muscle cell action potential (GO:0086014)	3.69101161
56	proline transport (GO:0015824)	3.59213790
57	protein carboxylation (GO:0018214)	3.58315992
58	peptidyl-glutamic acid carboxylation (GO:0017187)	3.58315992
59	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	3.57889366
60	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.54477704
61	adenine nucleotide transport (GO:0051503)	3.54336170
62	aromatic amino acid family catabolic process (GO:0009074)	3.53454968
63	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.50765951
64	neurotransmitter secretion (GO:0007269)	3.50482707
65	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	3.47146804
66	regulation of neuronal synaptic plasticity (GO:0048168)	3.46913915
67	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.44254360
68	auditory behavior (GO:0031223)	3.42711116
69	chondroitin sulfate catabolic process (GO:0030207)	3.42270205
70	regulation of glutamate receptor signaling pathway (GO:1900449)	3.39802453
71	layer formation in cerebral cortex (GO:0021819)	3.39556149
72	regulation of astrocyte differentiation (GO:0048710)	3.39147651
73	cellular response to cholesterol (GO:0071397)	3.37206999
74	dicarboxylic acid biosynthetic process (GO:0043650)	3.35406264
75	drug metabolic process (GO:0017144)	3.33759944
76	urea metabolic process (GO:0019627)	3.33274761
77	glutamate receptor signaling pathway (GO:0007215)	3.30953110
78	bile acid biosynthetic process (GO:0006699)	3.30800297
79	regulation of cholesterol esterification (GO:0010872)	3.30707650
80	fibrinolysis (GO:0042730)	3.30368674
81	exploration behavior (GO:0035640)	3.29568500
82	acidic amino acid transport (GO:0015800)	3.28223908
83	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.27896485
84	blood coagulation, intrinsic pathway (GO:0007597)	3.27071202
85	L-serine transport (GO:0015825)	3.25998054
86	neuronal action potential propagation (GO:0019227)	3.24176174
87	regulation of long-term neuronal synaptic plasticity (GO:0048169)	3.23596205
88	regulation of synaptic vesicle exocytosis (GO:2000300)	3.21286422
89	postsynaptic membrane organization (GO:0001941)	3.20545911
90	positive regulation of cellular amide metabolic process (GO:0034250)	3.20023693
91	phospholipid efflux (GO:0033700)	3.18987520
92	protein localization to synapse (GO:0035418)	3.16173785
93	synaptic transmission, glutamatergic (GO:0035249)	3.15235749
94	reverse cholesterol transport (GO:0043691)	3.14261683
95	regulation of amyloid precursor protein catabolic process (GO:1902991)	3.13934712
96	presynaptic membrane organization (GO:0097090)	3.12523734
97	nitrogen cycle metabolic process (GO:0071941)	3.12479865
98	long-term synaptic potentiation (GO:0060291)	3.11100269
99	regulation of synapse structural plasticity (GO:0051823)	3.09642133
100	long-term memory (GO:0007616)	3.09225048
101	cerebellar granule cell differentiation (GO:0021707)	3.07642708
102	neurotransmitter transport (GO:0006836)	3.07301468
103	oxidative demethylation (GO:0070989)	3.06465903
104	neuronal ion channel clustering (GO:0045161)	3.05031885
105	regulation of triglyceride catabolic process (GO:0010896)	3.03613842
106	regulation of synaptic transmission, glutamatergic (GO:0051966)	3.03585198
107	protein-lipid complex remodeling (GO:0034368)	3.00885386
108	macromolecular complex remodeling (GO:0034367)	3.00885386
109	plasma lipoprotein particle remodeling (GO:0034369)	3.00885386
110	transmission of nerve impulse (GO:0019226)	2.99259939
111	bile acid metabolic process (GO:0008206)	2.98513888
112	negative regulation of smoothened signaling pathway (GO:0045879)	2.98359800
113	ovulation cycle (GO:0042698)	2.97866803
114	purine nucleotide transport (GO:0015865)	2.97590013
115	protein activation cascade (GO:0072376)	2.96648209
116	regulation of neurotransmitter levels (GO:0001505)	2.96513487
117	negative regulation of glial cell differentiation (GO:0045686)	2.96243147
118	high-density lipoprotein particle remodeling (GO:0034375)	2.95321838
119	cellular glucuronidation (GO:0052695)	2.94927412
120	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.93590349
121	acylglycerol homeostasis (GO:0055090)	2.92107251
122	triglyceride homeostasis (GO:0070328)	2.92107251
123	regulation of synaptic vesicle transport (GO:1902803)	2.91269738
124	L-glutamate transport (GO:0015813)	2.90702950
125	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.90001167
126	response to mercury ion (GO:0046689)	2.87984708
127	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.87483038
128	regulation of membrane repolarization (GO:0060306)	2.87068565
129	cellular response to sterol (GO:0036315)	2.86569276
130	cilium movement (GO:0003341)	2.86287459
131	negative regulation of lipase activity (GO:0060192)	2.85748873
132	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	2.85601696
133	regulation of respiratory system process (GO:0044065)	2.84974717
134	regulation of plasminogen activation (GO:0010755)	2.84740787
135	amino-acid betaine metabolic process (GO:0006577)	2.84347078
136	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.83685142
137	ethanol metabolic process (GO:0006067)	2.83196225
138	presynaptic membrane assembly (GO:0097105)	2.83019317
139	complement activation (GO:0006956)	2.80614786
140	serine transport (GO:0032329)	2.78766219
141	regulation of glomerular filtration (GO:0003093)	2.77642893
142	regulation of synaptic plasticity (GO:0048167)	2.75673014
143	dermatan sulfate biosynthetic process (GO:0030208)	2.74064843
144	innervation (GO:0060384)	2.73225843
145	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.72866079
146	dermatan sulfate metabolic process (GO:0030205)	2.68654537
147	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.66871082
148	positive regulation of dendritic spine development (GO:0060999)	2.66799416
149	female mating behavior (GO:0060180)	2.65826798
150	membrane repolarization (GO:0086009)	2.65141153
151	oligodendrocyte differentiation (GO:0048709)	2.64348944
152	prepulse inhibition (GO:0060134)	2.60932819

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.93172609
2	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.56326785
3	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	3.09615830
4	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.96888451
5	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.89815529
6	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.79253265
7	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.67064134
8	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.67064134
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.64479354
10	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.62554754
11	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.57244142
12	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.55493789
13	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.54827171
14	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.52609696
15	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.48972005
16	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.44960234
17	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.44416199
18	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.38457075
19	AR_21572438_ChIP-Seq_LNCaP_Human	2.34491258
20	DROSHA_22980978_ChIP-Seq_HELA_Human	2.32547517
21	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.29175693
22	REST_21632747_ChIP-Seq_MESCs_Mouse	2.25169388
23	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.18858381
24	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.17528173
25	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.16252125
26	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.14956370
27	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.00213164
28	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.98820372
29	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.95202390
30	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.89644396
31	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.84958574
32	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.72014616
33	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.68122264
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.67364028
35	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.65354154
36	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.62932788
37	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.59841202
38	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.59786205
39	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.56249734
40	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.54558204
41	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.54539533
42	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.50229342
43	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47953995
44	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.47025662
45	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44285597
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42807771
47	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.39921928
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.38362379
49	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.36657803
50	RXR_22108803_ChIP-Seq_LS180_Human	1.34683472
51	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.32013816
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30807315
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29970312
54	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.29289852
55	P300_19829295_ChIP-Seq_ESCs_Human	1.28182731
56	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.25753288
57	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.24814339
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.24561212
59	CTCF_27219007_Chip-Seq_Bcells_Human	1.20340754
60	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.20144443
61	BCAT_22108803_ChIP-Seq_LS180_Human	1.19499813
62	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.19354538
63	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.19330637
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19258198
65	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.18402328
66	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.18229457
67	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.18061145
68	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.17154131
69	* AR_25329375_ChIP-Seq_VCAP_Human	1.16304919
70	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15894046
71	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.14857693
72	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.14706984
73	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.13506441
74	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.12774747
75	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12633318
76	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12300067
77	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.12292477
78	* AR_19668381_ChIP-Seq_PC3_Human	1.10474701
79	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.10415784
80	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.09900741
81	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.09454361
82	TP53_18474530_ChIP-ChIP_U2OS_Human	1.08533948
83	KDM2B_26808549_Chip-Seq_K562_Human	1.07947383
84	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07274431
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05617421
86	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.05571942
87	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.05133495
88	LXR_22292898_ChIP-Seq_THP-1_Human	1.04128686
89	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.03535749
90	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.03294100
91	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.02516216
92	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01796655
93	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.01673184
94	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.01399678
95	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.01366099
96	* STAT3_23295773_ChIP-Seq_U87_Human	1.01100684
97	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.99591574
98	SMC4_20622854_ChIP-Seq_HELA_Human	0.99375123
99	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.98794525
100	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.97867567
101	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97867567
102	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.97856420
103	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97479768
104	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.96521703
105	HTT_18923047_ChIP-ChIP_STHdh_Human	0.96140149
106	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.95441203
107	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.93864554
108	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.93001833
109	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.92891186
110	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.92764666
111	TP53_16413492_ChIP-PET_HCT116_Human	0.92748834
112	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.92601613
113	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.91447024
114	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.91034872
115	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90208105
116	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.89746019
117	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.89066747
118	RUNX2_22187159_ChIP-Seq_PCA_Human	0.88597831
119	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.88184472
120	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.87639182
121	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.85890963
122	TCF4_23295773_ChIP-Seq_U87_Human	0.85022936
123	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.84919208
124	MYC_19915707_ChIP-ChIP_AK7_Human	0.84826832
125	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.83824488
126	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.83538034
127	AHR_22903824_ChIP-Seq_MCF-7_Human	0.83420062
128	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.83315438
129	RNF2_27304074_Chip-Seq_NSC_Mouse	0.83247471
130	* OCT4_19829295_ChIP-Seq_ESCs_Human	0.82817390
131	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.82713183
132	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.80830331
133	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.80590239
134	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.78943585
135	KLF4_19829295_ChIP-Seq_ESCs_Human	0.77864949
136	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.75653318
137	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.74256894
138	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.74126668
139	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.73805768
140	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.72253528
141	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.70592515
142	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.69799271

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.56879518
2	MP0002139_abnormal_hepatobiliary_system	4.45644256
3	MP0004858_abnormal_nervous_system	3.63510128
4	MP0003690_abnormal_glial_cell	3.57007265
5	MP0005646_abnormal_pituitary_gland	3.47908905
6	MP0005423_abnormal_somatic_nervous	3.22089091
7	MP0003635_abnormal_synaptic_transmissio	3.14256758
8	MP0003880_abnormal_central_pattern	3.10395958
9	MP0005365_abnormal_bile_salt	2.99990782
10	MP0005085_abnormal_gallbladder_physiolo	2.95742383
11	MP0008875_abnormal_xenobiotic_pharmacok	2.93199253
12	MP0003136_yellow_coat_color	2.91827341
13	MP0009780_abnormal_chondrocyte_physiolo	2.80252909
14	MP0004270_analgesia	2.78399434
15	MP0009745_abnormal_behavioral_response	2.75305617
16	MP0002064_seizures	2.71891765
17	MP0009046_muscle_twitch	2.70809128
18	MP0001486_abnormal_startle_reflex	2.67877059
19	MP0003329_amyloid_beta_deposits	2.54455511
20	MP0002063_abnormal_learning/memory/cond	2.51857253
21	MP0004885_abnormal_endolymph	2.42506174
22	MP0002572_abnormal_emotion/affect_behav	2.32847188
23	MP0001440_abnormal_grooming_behavior	2.30342427
24	MP0005360_urolithiasis	2.30202155
25	MP0001968_abnormal_touch/_nociception	2.23722896
26	MP0003195_calcinosis	2.18716710
27	MP0002272_abnormal_nervous_system	2.04203369
28	MP0002736_abnormal_nociception_after	2.02669866
29	MP0009384_cardiac_valve_regurgitation	2.02064975
30	MP0002734_abnormal_mechanical_nocicepti	1.95433626
31	MP0003634_abnormal_glial_cell	1.93020780
32	MP0001501_abnormal_sleep_pattern	1.81046684
33	MP0005167_abnormal_blood-brain_barrier	1.80902965
34	MP0008569_lethality_at_weaning	1.80168151
35	MP0003075_altered_response_to	1.78696035
36	MP0010329_abnormal_lipoprotein_level	1.78463144
37	MP0002254_reproductive_system_inflammat	1.77783173
38	MP0000778_abnormal_nervous_system	1.77615197
39	MP0002653_abnormal_ependyma_morphology	1.75057778
40	MP0001502_abnormal_circadian_rhythm	1.72804297
41	MP0002557_abnormal_social/conspecific_i	1.72744894
42	MP0005645_abnormal_hypothalamus_physiol	1.71276135
43	MP0003633_abnormal_nervous_system	1.69729923
44	MP0002733_abnormal_thermal_nociception	1.68372783
45	MP0001984_abnormal_olfaction	1.66468098
46	MP0002067_abnormal_sensory_capabilities	1.66087737
47	MP0003868_abnormal_feces_composition	1.64765306
48	MP0003252_abnormal_bile_duct	1.62916863
49	MP0001485_abnormal_pinna_reflex	1.59676360
50	MP0002638_abnormal_pupillary_reflex	1.53966515
51	MP0001970_abnormal_pain_threshold	1.46834854
52	MP0005332_abnormal_amino_acid	1.36715711
53	MP0003631_nervous_system_phenotype	1.36247270
54	MP0001666_abnormal_nutrient_absorption	1.34650758
55	MP0004142_abnormal_muscle_tone	1.30598107
56	MP0001986_abnormal_taste_sensitivity	1.29151332
57	MP0005386_behavior/neurological_phenoty	1.27676254
58	MP0004924_abnormal_behavior	1.27676254
59	MP0005551_abnormal_eye_electrophysiolog	1.26954507
60	MP0000604_amyloidosis	1.26740752
61	MP0002138_abnormal_hepatobiliary_system	1.22638307
62	MP0002735_abnormal_chemical_nociception	1.21388761
63	MP0002882_abnormal_neuron_morphology	1.20453906
64	MP0003183_abnormal_peptide_metabolism	1.19504524
65	MP0000955_abnormal_spinal_cord	1.19382652
66	MP0003191_abnormal_cellular_cholesterol	1.19319863
67	MP0002909_abnormal_adrenal_gland	1.18928700
68	MP0005670_abnormal_white_adipose	1.16732350
69	MP0005623_abnormal_meninges_morphology	1.15266316
70	MP0003279_aneurysm	1.13862487
71	MP0001905_abnormal_dopamine_level	1.12206764
72	MP0002152_abnormal_brain_morphology	1.11790179
73	MP0002876_abnormal_thyroid_physiology	1.11410410
74	MP0009840_abnormal_foam_cell	1.11310694
75	MP0003632_abnormal_nervous_system	1.10734250
76	MP0002089_abnormal_postnatal_growth/wei	1.10703070
77	MP0002066_abnormal_motor_capabilities/c	1.10222484
78	MP0008874_decreased_physiological_sensi	1.09293448
79	MP0003137_abnormal_impulse_conducting	1.09240882
80	MP0005377_hearing/vestibular/ear_phenot	1.08709952
81	MP0003878_abnormal_ear_physiology	1.08709952
82	MP0004215_abnormal_myocardial_fiber	1.07892356
83	MP0000920_abnormal_myelination	1.06163057
84	MP0003011_delayed_dark_adaptation	1.05828940
85	MP0002118_abnormal_lipid_homeostasis	1.05092977
86	MP0005253_abnormal_eye_physiology	1.02409870
87	MP0001963_abnormal_hearing_physiology	1.02383172
88	MP0001853_heart_inflammation	1.00229353
89	MP0002090_abnormal_vision	0.99663160
90	MP0005535_abnormal_body_temperature	0.95252743
91	MP0004742_abnormal_vestibular_system	0.92058743
92	MP0000631_abnormal_neuroendocrine_gland	0.90560741
93	MP0002229_neurodegeneration	0.89147493
94	MP0005379_endocrine/exocrine_gland_phen	0.88994808
95	MP0000026_abnormal_inner_ear	0.88520274
96	MP0004811_abnormal_neuron_physiology	0.88455531
97	MP0002184_abnormal_innervation	0.88200874
98	MP0000049_abnormal_middle_ear	0.87507672
99	MP0000566_synostosis	0.83959829
100	MP0006276_abnormal_autonomic_nervous	0.82698798
101	MP0003879_abnormal_hair_cell	0.81933190
102	MP0002249_abnormal_larynx_morphology	0.78268791
103	MP0000751_myopathy	0.78208247
104	MP0006072_abnormal_retinal_apoptosis	0.75945741
105	MP0003938_abnormal_ear_development	0.75906443
106	MP0005171_absent_coat_pigmentation	0.74977432
107	MP0002822_catalepsy	0.73233927
108	MP0005595_abnormal_vascular_smooth	0.70089745
109	MP0005166_decreased_susceptibility_to	0.69814606
110	MP0001299_abnormal_eye_distance/	0.69109735
111	MP0005584_abnormal_enzyme/coenzyme_acti	0.67109653
112	MP0002752_abnormal_somatic_nervous	0.66990233
113	MP0001177_atelectasis	0.66260544
114	MP0000428_abnormal_craniofacial_morphol	0.64813677
115	MP0002069_abnormal_eating/drinking_beha	0.63892411
116	MP0004130_abnormal_muscle_cell	0.63636362
117	MP0002971_abnormal_brown_adipose	0.63396115
118	MP0004019_abnormal_vitamin_homeostasis	0.63368874
119	MP0008872_abnormal_physiological_respon	0.63334355
120	MP0003172_abnormal_lysosome_physiology	0.59861081
121	MP0001943_abnormal_respiration	0.57382715
122	MP0005165_increased_susceptibility_to	0.56321236
123	MP0001529_abnormal_vocalization	0.55031376
124	MP0000609_abnormal_liver_physiology	0.52917118
125	MP0000639_abnormal_adrenal_gland	0.52140997
126	MP0000579_abnormal_nail_morphology	0.51898135
127	MP0001764_abnormal_homeostasis	0.49335316
128	MP0005448_abnormal_energy_balance	0.46310301
129	MP0005636_abnormal_mineral_homeostasis	0.43356705

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia of the phalanges of the hand (HP:0009802)	6.76960548
2	Aplasia involving bones of the extremities (HP:0009825)	6.76960548
3	Aplasia involving bones of the upper limbs (HP:0009823)	6.76960548
4	Complement deficiency (HP:0004431)	6.46935690
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.35663982
6	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.01890403
7	Deep venous thrombosis (HP:0002625)	5.74848563
8	Megalencephaly (HP:0001355)	5.34582665
9	Prolonged partial thromboplastin time (HP:0003645)	5.30415764
10	Abnormality of complement system (HP:0005339)	4.87083796
11	Hypobetalipoproteinemia (HP:0003563)	4.62895713
12	Diplopia (HP:0000651)	4.45173182
13	Abnormality of binocular vision (HP:0011514)	4.45173182
14	Focal motor seizures (HP:0011153)	4.41196351
15	Neurofibrillary tangles (HP:0002185)	4.31197938
16	Hemiparesis (HP:0001269)	4.30754125
17	Systemic lupus erythematosus (HP:0002725)	4.29659598
18	Hemiplegia (HP:0002301)	4.22731252
19	Abnormal ciliary motility (HP:0012262)	4.19594523
20	Joint hemorrhage (HP:0005261)	4.05138958
21	Hyperlipoproteinemia (HP:0010980)	4.03780182
22	Abnormal respiratory motile cilium physiology (HP:0012261)	3.94980166
23	Myokymia (HP:0002411)	3.89203236
24	Glomerulonephritis (HP:0000099)	3.88140576
25	Epileptic encephalopathy (HP:0200134)	3.43012164
26	Spontaneous abortion (HP:0005268)	3.38759053
27	Hypoplastic left heart (HP:0004383)	3.37873462
28	Conjugated hyperbilirubinemia (HP:0002908)	3.36743921
29	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.36450694
30	Cerebral inclusion bodies (HP:0100314)	3.31844602
31	Xanthomatosis (HP:0000991)	3.28987444
32	Focal seizures (HP:0007359)	3.19930820
33	Supranuclear gaze palsy (HP:0000605)	3.12440524
34	Visual hallucinations (HP:0002367)	3.09222453
35	Intrahepatic cholestasis (HP:0001406)	3.03933322
36	Humeroradial synostosis (HP:0003041)	3.03535397
37	Synostosis involving the elbow (HP:0003938)	3.03535397
38	Progressive cerebellar ataxia (HP:0002073)	2.98410106
39	Abnormal respiratory motile cilium morphology (HP:0005938)	2.94306137
40	Abnormal respiratory epithelium morphology (HP:0012253)	2.94306137
41	Torticollis (HP:0000473)	2.90147910
42	Rhinitis (HP:0012384)	2.90138408
43	Long nose (HP:0003189)	2.90008871
44	Generalized tonic-clonic seizures (HP:0002069)	2.83318181
45	Mixed hearing impairment (HP:0000410)	2.83178435
46	Abnormality of secondary sexual hair (HP:0009888)	2.80292323
47	Abnormality of the axillary hair (HP:0100134)	2.80292323
48	Short middle phalanx of the 5th finger (HP:0004220)	2.80253729
49	Action tremor (HP:0002345)	2.80064797
50	Split foot (HP:0001839)	2.76819382
51	Hypolipoproteinemia (HP:0010981)	2.76650030
52	Narrow nasal bridge (HP:0000446)	2.73937471
53	Abnormality of the common coagulation pathway (HP:0010990)	2.73029421
54	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.72962510
55	Absent/shortened dynein arms (HP:0200106)	2.72962510
56	Dysdiadochokinesis (HP:0002075)	2.71091282
57	Tetraparesis (HP:0002273)	2.69835608
58	Abnormality of the dental pulp (HP:0006479)	2.67993489
59	Postural instability (HP:0002172)	2.65787721
60	Spastic gait (HP:0002064)	2.64218003
61	Nephritis (HP:0000123)	2.58755274
62	Broad alveolar ridges (HP:0000187)	2.56811085
63	Clumsiness (HP:0002312)	2.56714282
64	Hypoplastic heart (HP:0001961)	2.53835477
65	Abnormal eating behavior (HP:0100738)	2.50464007
66	Short hallux (HP:0010109)	2.49618890
67	Abnormality of the intrinsic pathway (HP:0010989)	2.48154731
68	Maternal diabetes (HP:0009800)	2.47229748
69	Median cleft lip (HP:0000161)	2.45262669
70	Focal dystonia (HP:0004373)	2.44524391
71	Abnormality of permanent molar morphology (HP:0011071)	2.41228379
72	Abnormality of the dental root (HP:0006486)	2.41228379
73	Taurodontia (HP:0000679)	2.41228379
74	Abnormality of glycine metabolism (HP:0010895)	2.37985084
75	Abnormality of serine family amino acid metabolism (HP:0010894)	2.37985084
76	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.34923647
77	Craniofacial dystonia (HP:0012179)	2.33906961
78	Confusion (HP:0001289)	2.32957871
79	Dry hair (HP:0011359)	2.32915344
80	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.32462967
81	Hyperglycinemia (HP:0002154)	2.30101446
82	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.30041859
83	Hypoalphalipoproteinemia (HP:0003233)	2.29840022
84	Clonus (HP:0002169)	2.28138299
85	Status epilepticus (HP:0002133)	2.27989935
86	Papilledema (HP:0001085)	2.27694574
87	Hyperglycinuria (HP:0003108)	2.26274376
88	Cerebral hypomyelination (HP:0006808)	2.25605844
89	Abnormality of molar (HP:0011077)	2.24420980
90	Abnormality of molar morphology (HP:0011070)	2.24420980
91	Delusions (HP:0000746)	2.23832869
92	Depression (HP:0000716)	2.17832924
93	Obstructive sleep apnea (HP:0002870)	2.17519707
94	Mutism (HP:0002300)	2.16027690
95	Urinary bladder sphincter dysfunction (HP:0002839)	2.16026198
96	Truncal ataxia (HP:0002078)	2.14161491
97	Abnormality of the middle phalanges of the toes (HP:0010183)	2.13932440
98	Scanning speech (HP:0002168)	2.12188635
99	Neonatal short-limb short stature (HP:0008921)	2.10228427
100	Back pain (HP:0003418)	2.09503721
101	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.08897741
102	Delayed CNS myelination (HP:0002188)	2.07958511
103	Atrioventricular block (HP:0001678)	2.07797314
104	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.06538775
105	Bronchomalacia (HP:0002780)	2.06092315
106	Paraparesis (HP:0002385)	2.05276106
107	Adactyly (HP:0009776)	2.04928718
108	Epileptiform EEG discharges (HP:0011182)	2.03743992
109	Fat malabsorption (HP:0002630)	2.03565040
110	Abnormality of the periventricular white matter (HP:0002518)	2.03164301
111	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.02139987
112	Absence seizures (HP:0002121)	2.00133377
113	Mitral stenosis (HP:0001718)	1.99920075
114	Akinesia (HP:0002304)	1.99675514
115	Abnormality of pyrimidine metabolism (HP:0004353)	1.99306014
116	Dialeptic seizures (HP:0011146)	1.98508320
117	Dysmetria (HP:0001310)	1.98490967
118	Irritability (HP:0000737)	1.98275870
119	Tetraplegia (HP:0002445)	1.95657950
120	Abnormal gallbladder physiology (HP:0012438)	1.94813809
121	Cholecystitis (HP:0001082)	1.94813809
122	Annular pancreas (HP:0001734)	1.94469582
123	Retinal atrophy (HP:0001105)	1.93932640
124	Anxiety (HP:0000739)	1.93795247
125	Atonic seizures (HP:0010819)	1.93733233
126	Spastic tetraparesis (HP:0001285)	1.93580841
127	Fibular aplasia (HP:0002990)	1.91312362
128	Febrile seizures (HP:0002373)	1.91121861
129	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.90262535
130	Limb dystonia (HP:0002451)	1.89825380
131	Intention tremor (HP:0002080)	1.88914122
132	Neuronal loss in central nervous system (HP:0002529)	1.88532087
133	Recurrent gram-negative bacterial infections (HP:0005420)	1.87868698
134	Abnormal atrioventricular conduction (HP:0005150)	1.86637665
135	Lower limb muscle weakness (HP:0007340)	1.85909844
136	Hyperammonemia (HP:0001987)	1.85775444
137	Hypercholesterolemia (HP:0003124)	1.85521420
138	Poor eye contact (HP:0000817)	1.83613438
139	Urinary urgency (HP:0000012)	1.83537754
140	Ankle clonus (HP:0011448)	1.82764804
141	Heart block (HP:0012722)	1.81638042
142	Morphological abnormality of the pyramidal tract (HP:0002062)	1.81473977
143	Oligodactyly (hands) (HP:0001180)	1.79832749
144	Polyphagia (HP:0002591)	1.79758955
145	Rigidity (HP:0002063)	1.78321324
146	Peripheral hypomyelination (HP:0007182)	1.76355181
147	Bradykinesia (HP:0002067)	1.73945293
148	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.72149629
149	Increased circulating renin level (HP:0000848)	1.70935874
150	Cutaneous syndactyly (HP:0012725)	1.70354883
151	Microglossia (HP:0000171)	1.69682698
152	Hyperventilation (HP:0002883)	1.69256594
153	Metabolic alkalosis (HP:0200114)	1.68690411
154	Selective tooth agenesis (HP:0001592)	1.68561909
155	Athetosis (HP:0002305)	1.67860226
156	Hypoplastic pelvis (HP:0008839)	1.65257519
157	Abnormality of chromosome segregation (HP:0002916)	1.63941882
158	Impaired vibration sensation in the lower limbs (HP:0002166)	1.63797721
159	Facial shape deformation (HP:0011334)	1.63445941
160	Potter facies (HP:0002009)	1.63445941

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	4.06370250
2	NTRK2	3.78552611
3	LMTK2	3.64899645
4	TNIK	3.17765005
5	NTRK3	3.10661284
6	PHKG2	2.87137331
7	PHKG1	2.87137331
8	PRKD3	2.27463744
9	MAP3K9	2.16159895
10	MARK1	2.03461066
11	CASK	1.97883914
12	PAK6	1.97704615
13	MUSK	1.96537835
14	MINK1	1.89394276
15	MAP3K4	1.74358340
16	PRKCG	1.68636554
17	MAP2K7	1.66843193
18	MAPK13	1.66446904
19	RIPK1	1.66295140
20	DAPK2	1.60634396
21	MAPK12	1.52414115
22	NEK6	1.50767760
23	TYRO3	1.50625103
24	CAMKK1	1.44845440
25	NTRK1	1.43796760
26	TRIB3	1.38512781
27	CDK5	1.37289186
28	PDK2	1.36351206
29	SGK223	1.30345192
30	SGK494	1.30345192
31	SGK2	1.28123174
32	FES	1.26147310
33	PNCK	1.20790667
34	MAPK7	1.16696529
35	SIK1	1.11977524
36	PINK1	1.11726379
37	KSR2	1.08539676
38	SGK3	1.07849934
39	FGR	1.07280225
40	GRK5	1.05036507
41	DYRK1A	1.02850001
42	CAMK1G	1.02819033
43	PAK3	1.02408416
44	LATS2	0.99181622
45	CAMK2A	0.92864763
46	PRKCH	0.91431028
47	STK38	0.90892936
48	PRKCE	0.89873970
49	ROCK2	0.89668979
50	CDK15	0.88690399
51	PLK2	0.87618076
52	UHMK1	0.87171582
53	ROCK1	0.87166539
54	RIPK4	0.86682124
55	DAPK1	0.85557005
56	CDK18	0.84878071
57	MARK2	0.83378329
58	SIK2	0.83063580
59	BRSK1	0.82252868
60	KSR1	0.80276321
61	MAPK15	0.80028514
62	CDK11A	0.75844430
63	MAP2K4	0.75686489
64	CDK14	0.74345476
65	BMX	0.74186545
66	ADRBK1	0.72632756
67	TNK2	0.70662224
68	PRPF4B	0.69729909
69	SGK1	0.66985162
70	MAP3K2	0.66902588
71	CDC42BPA	0.66164267
72	CAMK2G	0.66099706
73	ERBB2	0.65741645
74	PRKCZ	0.63167337
75	CDK19	0.63000231
76	IRAK3	0.62576570
77	ARAF	0.62000284
78	OXSR1	0.61552294
79	CAMK4	0.61495561
80	CAMK1	0.60925140
81	BMPR2	0.60884668
82	CAMK2B	0.60687079
83	CAMKK2	0.58368175
84	RPS6KA3	0.58260252
85	ALK	0.55504068
86	CAMK1D	0.54777668
87	MAP3K13	0.54629091
88	DDR2	0.53861963
89	FGFR2	0.53487041
90	CDK3	0.53037991
91	PTK2B	0.51709067
92	PKN1	0.51606053
93	RET	0.51540240
94	PRKCA	0.51162382
95	PDPK1	0.50838289
96	MAPK10	0.49082160
97	DMPK	0.48959130
98	FYN	0.48155906
99	STK11	0.46173176
100	PDK1	0.44472392
101	SRC	0.44207666
102	MAPKAPK5	0.44005844
103	PRKG1	0.43382007
104	CAMK2D	0.43215382
105	MAP3K11	0.40629966
106	MAPK4	0.40208120
107	PIK3CA	0.39747202
108	PRKG2	0.39419558
109	IGF1R	0.39032374
110	PRKACG	0.38839511
111	PRKCQ	0.38382704
112	PRKACA	0.38199013
113	MOS	0.38070227
114	PRKCB	0.37405735
115	MAP2K6	0.37114668
116	MKNK2	0.36592507
117	MAP3K1	0.35848060
118	DAPK3	0.35493605
119	CSNK1D	0.35425133
120	CCNB1	0.34272032
121	CSNK1A1	0.33051890
122	RAF1	0.32626067
123	ABL2	0.30614696
124	CSNK1E	0.30373067
125	PRKD1	0.30275134
126	CSNK1G2	0.29760135

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	5.49287847
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.82027085
3	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	3.12206142
4	Nicotine addiction_Homo sapiens_hsa05033	3.05171232
5	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.88002275
6	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.86874243
7	Complement and coagulation cascades_Homo sapiens_hsa04610	2.81716199
8	GABAergic synapse_Homo sapiens_hsa04727	2.57720380
9	Caffeine metabolism_Homo sapiens_hsa00232	2.56943462
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.39948342
11	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.35389202
12	Glutamatergic synapse_Homo sapiens_hsa04724	2.30502323
13	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.25792443
14	Histidine metabolism_Homo sapiens_hsa00340	2.25687276
15	Salivary secretion_Homo sapiens_hsa04970	2.10699941
16	Retinol metabolism_Homo sapiens_hsa00830	2.09300000
17	Gastric acid secretion_Homo sapiens_hsa04971	1.99142213
18	Circadian entrainment_Homo sapiens_hsa04713	1.95178280
19	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.95127253
20	Insulin secretion_Homo sapiens_hsa04911	1.94183059
21	Phenylalanine metabolism_Homo sapiens_hsa00360	1.93999149
22	Olfactory transduction_Homo sapiens_hsa04740	1.91874598
23	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.91779301
24	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.91308402
25	Morphine addiction_Homo sapiens_hsa05032	1.87952749
26	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.81446436
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.78439529
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.74638349
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.64050512
30	Long-term potentiation_Homo sapiens_hsa04720	1.63353581
31	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.54261173
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.53442705
33	Tyrosine metabolism_Homo sapiens_hsa00350	1.49560494
34	Amphetamine addiction_Homo sapiens_hsa05031	1.48312793
35	Calcium signaling pathway_Homo sapiens_hsa04020	1.35771036
36	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.32035241
37	Taste transduction_Homo sapiens_hsa04742	1.27718881
38	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.26256064
39	Renin secretion_Homo sapiens_hsa04924	1.25807880
40	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.25570353
41	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.25224745
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.24972705
43	Bile secretion_Homo sapiens_hsa04976	1.24571378
44	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.24192122
45	Cocaine addiction_Homo sapiens_hsa05030	1.24140976
46	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.22183749
47	Fatty acid metabolism_Homo sapiens_hsa01212	1.20577023
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.16386429
49	Cholinergic synapse_Homo sapiens_hsa04725	1.16266185
50	cAMP signaling pathway_Homo sapiens_hsa04024	1.15521624
51	Long-term depression_Homo sapiens_hsa04730	1.15464658
52	Dopaminergic synapse_Homo sapiens_hsa04728	1.15417578
53	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.14909800
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.11801320
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10190643
56	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.08948496
57	Serotonergic synapse_Homo sapiens_hsa04726	1.06971717
58	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.04777505
59	Melanogenesis_Homo sapiens_hsa04916	1.04186853
60	Gap junction_Homo sapiens_hsa04540	1.03443627
61	Linoleic acid metabolism_Homo sapiens_hsa00591	1.02168991
62	Mineral absorption_Homo sapiens_hsa04978	1.01913296
63	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.00138585
64	Circadian rhythm_Homo sapiens_hsa04710	0.98146912
65	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.98124572
66	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.96933977
67	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.96021561
68	Pancreatic secretion_Homo sapiens_hsa04972	0.95339806
69	Pyruvate metabolism_Homo sapiens_hsa00620	0.95314521
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.93176698
71	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.92612271
72	PPAR signaling pathway_Homo sapiens_hsa03320	0.90410432
73	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.88906567
74	GnRH signaling pathway_Homo sapiens_hsa04912	0.88299342
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.88219659
76	Cardiac muscle contraction_Homo sapiens_hsa04260	0.86544064
77	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.84570966
78	Peroxisome_Homo sapiens_hsa04146	0.81697984
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.79825893
80	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.79628258
81	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.78929020
82	ABC transporters_Homo sapiens_hsa02010	0.76904937
83	Fatty acid degradation_Homo sapiens_hsa00071	0.76091290
84	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.74886461
85	Estrogen signaling pathway_Homo sapiens_hsa04915	0.74562815
86	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.73425893
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.72414590
88	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.72345167
89	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.72200690
90	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.72076162
91	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.69614533
92	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.68920288
93	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.68275104
94	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67817982
95	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.65625718
96	Axon guidance_Homo sapiens_hsa04360	0.65504305
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.64575462
98	Carbon metabolism_Homo sapiens_hsa01200	0.64546979
99	African trypanosomiasis_Homo sapiens_hsa05143	0.64109141
100	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.63820731
101	Basal cell carcinoma_Homo sapiens_hsa05217	0.62021713
102	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.60531896
103	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.60328736
104	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.58287194
105	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.57409466
106	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.57116594
107	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56280941
108	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55104321
109	Glioma_Homo sapiens_hsa05214	0.55044879
110	ErbB signaling pathway_Homo sapiens_hsa04012	0.54907450
111	Arginine biosynthesis_Homo sapiens_hsa00220	0.53937802
112	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.53493062
113	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53340365
114	Butanoate metabolism_Homo sapiens_hsa00650	0.49513737
115	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.48780559
116	Type II diabetes mellitus_Homo sapiens_hsa04930	0.47821455
117	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47691882
118	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45818769
119	Choline metabolism in cancer_Homo sapiens_hsa05231	0.45806758
120	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.44780962
121	Wnt signaling pathway_Homo sapiens_hsa04310	0.44759982
122	Ether lipid metabolism_Homo sapiens_hsa00565	0.42595290
123	Type I diabetes mellitus_Homo sapiens_hsa04940	0.42352791
124	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.39924048
125	Glucagon signaling pathway_Homo sapiens_hsa04922	0.39369948
126	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.38870520
127	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.38478918
128	Prion diseases_Homo sapiens_hsa05020	0.38366011
129	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.36818022
130	Rap1 signaling pathway_Homo sapiens_hsa04015	0.36349797
131	MAPK signaling pathway_Homo sapiens_hsa04010	0.35253382
132	Fat digestion and absorption_Homo sapiens_hsa04975	0.34424675
133	Propanoate metabolism_Homo sapiens_hsa00640	0.34322001
134	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.33025546
135	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.30193013
136	Lysosome_Homo sapiens_hsa04142	0.29761726
137	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.27154519
138	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26486597
139	Lysine degradation_Homo sapiens_hsa00310	0.25834384

SLC25A18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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