SLC25A19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)5.95891958
2cytidine metabolic process (GO:0046087)5.95891958
3cytidine catabolic process (GO:0006216)5.95891958
4pyrimidine ribonucleoside catabolic process (GO:0046133)5.69548815
5NADH metabolic process (GO:0006734)5.47673017
6tricarboxylic acid cycle (GO:0006099)5.44928820
7regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.88046365
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.74313223
9respiratory electron transport chain (GO:0022904)4.59331919
10regulation of acyl-CoA biosynthetic process (GO:0050812)4.57125706
11cellular response to zinc ion (GO:0071294)4.52946492
12electron transport chain (GO:0022900)4.46445715
13biotin metabolic process (GO:0006768)4.44037915
14regulation of sequestering of triglyceride (GO:0010889)4.34732280
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.32792821
16antigen processing and presentation of endogenous antigen (GO:0019883)4.25087459
17regulation of cofactor metabolic process (GO:0051193)4.19262333
18regulation of coenzyme metabolic process (GO:0051196)4.19262333
19B cell receptor signaling pathway (GO:0050853)4.03058142
20proteasome assembly (GO:0043248)3.94992306
21succinate metabolic process (GO:0006105)3.93684556
22ubiquinone biosynthetic process (GO:0006744)3.93422976
23quinone biosynthetic process (GO:1901663)3.93422976
24energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86901176
25ATP synthesis coupled proton transport (GO:0015986)3.86901176
26branched-chain amino acid catabolic process (GO:0009083)3.82048935
27chaperone-mediated protein transport (GO:0072321)3.81040828
28pseudouridine synthesis (GO:0001522)3.78758219
29valine metabolic process (GO:0006573)3.69101223
30rRNA modification (GO:0000154)3.68316201
31DNA strand elongation involved in DNA replication (GO:0006271)3.63592716
32carnitine shuttle (GO:0006853)3.62562305
33branched-chain amino acid metabolic process (GO:0009081)3.59411701
34inner mitochondrial membrane organization (GO:0007007)3.55627090
35ubiquinone metabolic process (GO:0006743)3.53881024
36DNA strand elongation (GO:0022616)3.52091745
37oxidative phosphorylation (GO:0006119)3.48240994
38telomere maintenance via semi-conservative replication (GO:0032201)3.44701243
39carnitine transmembrane transport (GO:1902603)3.42058936
40amino-acid betaine transport (GO:0015838)3.37861168
41carnitine transport (GO:0015879)3.37861168
42fatty acid beta-oxidation (GO:0006635)3.37213727
43axon ensheathment in central nervous system (GO:0032291)3.24824337
44central nervous system myelination (GO:0022010)3.24824337
45fatty acid transmembrane transport (GO:1902001)3.21018414
46regulation of mitochondrial translation (GO:0070129)3.20413581
47protein complex biogenesis (GO:0070271)3.19828410
48rRNA methylation (GO:0031167)3.19561134
49maturation of 5.8S rRNA (GO:0000460)3.18290820
50lipid particle organization (GO:0034389)3.16553370
51ribosomal small subunit biogenesis (GO:0042274)3.14077254
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.13077044
53mitochondrial respiratory chain complex I assembly (GO:0032981)3.13077044
54NADH dehydrogenase complex assembly (GO:0010257)3.13077044
55mitochondrial RNA metabolic process (GO:0000959)3.11595557
56DNA replication checkpoint (GO:0000076)3.09421375
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08247381
58acetyl-CoA metabolic process (GO:0006084)3.05542530
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05412966
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05412966
61NIK/NF-kappaB signaling (GO:0038061)3.01632905
62acyl-CoA biosynthetic process (GO:0071616)3.00998454
63thioester biosynthetic process (GO:0035384)3.00998454
64somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00589126
65somatic hypermutation of immunoglobulin genes (GO:0016446)3.00589126
66telomere maintenance via recombination (GO:0000722)2.99619392
67triglyceride catabolic process (GO:0019433)2.99079347
68rRNA processing (GO:0006364)2.97577788
69cytochrome complex assembly (GO:0017004)2.92699615
70respiratory chain complex IV assembly (GO:0008535)2.92410899
71mitochondrial respiratory chain complex assembly (GO:0033108)2.90822859
72negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.88449259
73negative regulation of ligase activity (GO:0051352)2.88449259
74triglyceride biosynthetic process (GO:0019432)2.87820071
75ribosome assembly (GO:0042255)2.86147141
76tricarboxylic acid metabolic process (GO:0072350)2.85678579
77rRNA metabolic process (GO:0016072)2.85274810
78transcription from mitochondrial promoter (GO:0006390)2.85145640
79ribosome biogenesis (GO:0042254)2.83573313
80response to epinephrine (GO:0071871)2.83284934
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82395525
82regulation of sulfur metabolic process (GO:0042762)2.82308722
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82288490
84purine nucleobase biosynthetic process (GO:0009113)2.81598564
85cellular response to epinephrine stimulus (GO:0071872)2.81461266
86regulation of B cell receptor signaling pathway (GO:0050855)2.81312342
87nucleobase biosynthetic process (GO:0046112)2.81308786
88folic acid-containing compound biosynthetic process (GO:0009396)2.81009826
89brown fat cell differentiation (GO:0050873)2.80851862
90quaternary ammonium group transport (GO:0015697)2.80695615
91negative regulation of interleukin-12 production (GO:0032695)2.79747397
92purine nucleotide salvage (GO:0032261)2.76937209
93fatty acid catabolic process (GO:0009062)2.76778933
94response to peptidoglycan (GO:0032494)2.75733886
95glycerol metabolic process (GO:0006071)2.74587437
96ribonucleoprotein complex biogenesis (GO:0022613)2.72773716
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.71916615
98GMP metabolic process (GO:0046037)2.71209899
99IMP biosynthetic process (GO:0006188)2.70769848
100ribosomal small subunit assembly (GO:0000028)2.70206093
101deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70145997
102mitotic recombination (GO:0006312)2.69911776
103coenzyme A biosynthetic process (GO:0015937)2.69832321
104peptidyl-histidine modification (GO:0018202)2.69256952
105cellular response to interleukin-15 (GO:0071350)2.68736378
106DNA replication initiation (GO:0006270)2.68705050
107mitochondrial transport (GO:0006839)2.68327484
108establishment of protein localization to mitochondrion (GO:0072655)2.68270609
109maturation of SSU-rRNA (GO:0030490)2.67896509
110oxaloacetate metabolic process (GO:0006107)2.66660118
111fatty acid oxidation (GO:0019395)2.64973634
112establishment of mitochondrion localization (GO:0051654)2.64093247
113tRNA methylation (GO:0030488)2.62862732
114lipid oxidation (GO:0034440)2.61911587
115positive regulation of mitochondrial fission (GO:0090141)2.60746246
116adaptation of signaling pathway (GO:0023058)2.60572917
117DNA deamination (GO:0045006)2.60536856
118protein localization to mitochondrion (GO:0070585)2.58140261
119acylglycerol biosynthetic process (GO:0046463)2.57885570
120neutral lipid biosynthetic process (GO:0046460)2.57885570
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.57493856
122fatty-acyl-CoA metabolic process (GO:0035337)2.57415415
123DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.56494812
124cellular component biogenesis (GO:0044085)2.56250024
125termination of RNA polymerase III transcription (GO:0006386)2.55775876
126transcription elongation from RNA polymerase III promoter (GO:0006385)2.55775876
127purine deoxyribonucleotide catabolic process (GO:0009155)2.55746806
128creatine metabolic process (GO:0006600)2.55234583
129positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.55204381
130regulation of fatty acid oxidation (GO:0046320)2.53992527
131immunoglobulin mediated immune response (GO:0016064)2.53904073
132signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.53679951
133signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.53679951
134signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53679951
135protein targeting to mitochondrion (GO:0006626)2.53404156
136intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.52871172
137signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.52871172
138metallo-sulfur cluster assembly (GO:0031163)2.52196956
139iron-sulfur cluster assembly (GO:0016226)2.52196956
140regulation of B cell differentiation (GO:0045577)2.51713970
141tRNA modification (GO:0006400)2.51466901
142aerobic respiration (GO:0009060)2.51102370
143nucleotide-excision repair, DNA gap filling (GO:0006297)2.50663470
144response to interleukin-15 (GO:0070672)2.50422765
145pteridine-containing compound biosynthetic process (GO:0042559)2.50216997
146serine transport (GO:0032329)2.49873038
147nucleoside salvage (GO:0043174)2.49558802
148proton transport (GO:0015992)2.49258798
149hydrogen transport (GO:0006818)2.49240677
150regulation of chronic inflammatory response (GO:0002676)2.49120118
151pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.49013441
152signal transduction involved in DNA integrity checkpoint (GO:0072401)2.48799901
153signal transduction involved in DNA damage checkpoint (GO:0072422)2.48799901
154deoxyribonucleotide catabolic process (GO:0009264)2.48540333
155formation of translation preinitiation complex (GO:0001731)2.47662730
156regulation of cellular amino acid metabolic process (GO:0006521)2.47417710
157positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.47009137
158neutral lipid catabolic process (GO:0046461)2.46549062
159acylglycerol catabolic process (GO:0046464)2.46549062
160regulation of mitochondrial fission (GO:0090140)2.45788002
161nucleotide salvage (GO:0043173)2.45036944
162positive regulation of gamma-delta T cell activation (GO:0046645)2.44532591
163ncRNA processing (GO:0034470)2.44051487
164signal transduction involved in cell cycle checkpoint (GO:0072395)2.43961095
165deoxyribose phosphate catabolic process (GO:0046386)2.43662189
166telomere maintenance via telomere lengthening (GO:0010833)2.42391263
167antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.41837059
168alditol metabolic process (GO:0019400)2.40680288
169positive regulation of chemokine biosynthetic process (GO:0045080)2.40469603
170purine-containing compound salvage (GO:0043101)2.39269832
171positive regulation of ligase activity (GO:0051351)2.39246339
172antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.39134991
173regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.39111784
174lipid storage (GO:0019915)2.38810888
175regulation of vitamin D biosynthetic process (GO:0060556)2.38304097
176B cell mediated immunity (GO:0019724)2.37806072
177tRNA processing (GO:0008033)2.36859889
178negative regulation of myeloid cell apoptotic process (GO:0033033)2.36800951
179negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.36550513
180mitochondrial fusion (GO:0008053)2.36529059
181positive regulation of B cell differentiation (GO:0045579)2.36359326
182RNA methylation (GO:0001510)2.36324084
183long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.36035570
184kinetochore organization (GO:0051383)2.35965192
185RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.35955182
186tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.35955182
187kinetochore assembly (GO:0051382)2.35801975
188glycine transport (GO:0015816)2.35442017
189aminoglycoside antibiotic metabolic process (GO:0030647)2.34508380
190regulation of B cell apoptotic process (GO:0002902)2.33821885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.61940368
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.52449271
3E2F7_22180533_ChIP-Seq_HELA_Human5.54083911
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.31209008
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.22099719
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.18104199
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.12660065
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85288872
9* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74749151
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65159775
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.61749808
12* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.55488636
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52119728
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34446555
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.33903326
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.25403382
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15340924
18* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13605253
19* ETS1_20019798_ChIP-Seq_JURKAT_Human2.02804665
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.00705118
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99287958
22XRN2_22483619_ChIP-Seq_HELA_Human1.96403932
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96049289
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.91721167
25* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89178989
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.89063669
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88660098
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.82738362
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.81300646
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80826572
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80690774
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79769597
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.77837247
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.76211084
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75396619
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67631184
37VDR_21846776_ChIP-Seq_THP-1_Human1.65103342
38CIITA_25753668_ChIP-Seq_RAJI_Human1.62781935
39* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62306383
40TTF2_22483619_ChIP-Seq_HELA_Human1.61033756
41KDM5A_27292631_Chip-Seq_BREAST_Human1.60406488
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59346176
43* RUNX_20019798_ChIP-Seq_JUKART_Human1.58693677
44FOXP3_21729870_ChIP-Seq_TREG_Human1.56655491
45* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55410656
46* MYC_22102868_ChIP-Seq_BL_Human1.54834676
47TFEB_21752829_ChIP-Seq_HELA_Human1.51612299
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51013650
49* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.50573303
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48277306
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48137401
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47851229
53* E2F1_21310950_ChIP-Seq_MCF-7_Human1.46774376
54* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45877665
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42621935
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40747282
57* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39753793
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37453640
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36899982
60VDR_23849224_ChIP-Seq_CD4+_Human1.36446188
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36018703
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35918848
63ELK1_19687146_ChIP-ChIP_HELA_Human1.35745004
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35224071
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34914520
66BCL6_27268052_Chip-Seq_Bcells_Human1.33996768
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.31958049
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31864201
69* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30572450
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29975987
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29325285
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24274432
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24239657
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.22296011
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22152143
76MAF_26560356_Chip-Seq_TH2_Human1.19891956
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19877340
78* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19632301
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17485316
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16166129
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15337818
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14679615
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13865946
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13545304
85* RARB_27405468_Chip-Seq_BRAIN_Mouse1.13453899
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.13300707
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12384074
88CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09920885
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08479986
90BCOR_27268052_Chip-Seq_Bcells_Human1.06971804
91TAF15_26573619_Chip-Seq_HEK293_Human1.05997145
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05157871
93* VDR_24763502_ChIP-Seq_THP-1_Human1.04117427
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.03656389
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02941059
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01965977
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01103545
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00782446
99MYC_18940864_ChIP-ChIP_HL60_Human1.00743763
100SPI1_23547873_ChIP-Seq_NB4_Human0.99650396
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99128328
102SCL_19346495_ChIP-Seq_HPC-7_Human0.99124338
103GABP_19822575_ChIP-Seq_HepG2_Human0.97518680
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96084987
105* IRF8_27001747_Chip-Seq_BMDM_Mouse0.96065771
106P300_27268052_Chip-Seq_Bcells_Human0.95560183
107GATA3_27048872_Chip-Seq_THYMUS_Human0.94546488
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93067505
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92391551
110GATA3_26560356_Chip-Seq_TH2_Human0.91800922
111* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90530089
112NANOG_20526341_ChIP-Seq_ESCs_Human0.90354255
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90321955
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90113641
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89700236
116* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89364975
117STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89105384
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88914135
119TET1_21451524_ChIP-Seq_MESCs_Mouse0.88870385
120* MYB_26560356_Chip-Seq_TH2_Human0.88472400
121MAF_26560356_Chip-Seq_TH1_Human0.88207694
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.87835794
123SPI1_23127762_ChIP-Seq_K562_Human0.87093747
124MYB_26560356_Chip-Seq_TH1_Human0.85854483
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85555717
126DCP1A_22483619_ChIP-Seq_HELA_Human0.85287903
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85006843
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83163351
129FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.83016617
130ELF1_20517297_ChIP-Seq_JURKAT_Human0.82912810
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.82866191
132* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81244306
133REST_21632747_ChIP-Seq_MESCs_Mouse0.79280645
134TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79101639
135FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78540171
136EGR1_19032775_ChIP-ChIP_M12_Human0.78420294
137PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77940242
138GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77757263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.41905562
2MP0003806_abnormal_nucleotide_metabolis3.67915770
3MP0010094_abnormal_chromosome_stability3.34027455
4MP0003646_muscle_fatigue3.11818615
5MP0003693_abnormal_embryo_hatching3.03432469
6MP0001835_abnormal_antigen_presentation3.01366642
7MP0003111_abnormal_nucleus_morphology2.80975063
8MP0008058_abnormal_DNA_repair2.70428224
9MP0005058_abnormal_lysosome_morphology2.61370900
10* MP0006036_abnormal_mitochondrial_physio2.57217462
11MP0005387_immune_system_phenotype2.42163282
12MP0001790_abnormal_immune_system2.42163282
13MP0008057_abnormal_DNA_replication2.41433663
14MP0009840_abnormal_foam_cell2.37670955
15MP0005666_abnormal_adipose_tissue2.37517348
16MP0001986_abnormal_taste_sensitivity2.37283816
17MP0004130_abnormal_muscle_cell2.25519174
18MP0003077_abnormal_cell_cycle2.21264709
19MP0001800_abnormal_humoral_immune2.18644069
20MP0004957_abnormal_blastocyst_morpholog2.17861280
21MP0006082_CNS_inflammation2.16501616
22MP0008007_abnormal_cellular_replicative2.09962242
23MP0003303_peritoneal_inflammation2.09129879
24MP0003880_abnormal_central_pattern1.93545052
25MP0005671_abnormal_response_to1.92574493
26MP0003172_abnormal_lysosome_physiology1.90778587
27MP0003436_decreased_susceptibility_to1.87211194
28MP0001905_abnormal_dopamine_level1.80211580
29MP0005535_abnormal_body_temperature1.79485580
30MP0005423_abnormal_somatic_nervous1.76142973
31MP0002971_abnormal_brown_adipose1.73294355
32MP0000372_irregular_coat_pigmentation1.71441584
33MP0001873_stomach_inflammation1.71408633
34MP0002837_dystrophic_cardiac_calcinosis1.68921429
35MP0000920_abnormal_myelination1.68692894
36MP0005375_adipose_tissue_phenotype1.65104361
37MP0000685_abnormal_immune_system1.64387369
38MP0001529_abnormal_vocalization1.63200198
39MP0002139_abnormal_hepatobiliary_system1.61724694
40MP0005000_abnormal_immune_tolerance1.59025214
41MP0009278_abnormal_bone_marrow1.58874345
42MP0001545_abnormal_hematopoietic_system1.56823720
43MP0005397_hematopoietic_system_phenotyp1.56823720
44MP0004043_abnormal_pH_regulation1.54335326
45MP0002452_abnormal_antigen_presenting1.53879721
46MP0003786_premature_aging1.53427541
47MP0002723_abnormal_immune_serum1.52949911
48MP0003718_maternal_effect1.52712911
49MP0009046_muscle_twitch1.51729248
50MP0002272_abnormal_nervous_system1.51507838
51MP0002148_abnormal_hypersensitivity_rea1.51500764
52MP0006035_abnormal_mitochondrial_morpho1.51417586
53MP0009764_decreased_sensitivity_to1.49795509
54MP0002420_abnormal_adaptive_immunity1.49169830
55MP0004185_abnormal_adipocyte_glucose1.48739385
56MP0000013_abnormal_adipose_tissue1.48487422
57MP0003329_amyloid_beta_deposits1.46507931
58MP0004036_abnormal_muscle_relaxation1.43677935
59MP0001819_abnormal_immune_cell1.43526661
60MP0004142_abnormal_muscle_tone1.42953684
61MP0002332_abnormal_exercise_endurance1.40563057
62MP0000343_altered_response_to1.40184779
63MP0001845_abnormal_inflammatory_respons1.39876131
64MP0003690_abnormal_glial_cell1.39809773
65* MP0005584_abnormal_enzyme/coenzyme_acti1.39436430
66MP0002405_respiratory_system_inflammati1.38839034
67MP0005551_abnormal_eye_electrophysiolog1.38052771
68MP0002064_seizures1.37525719
69MP0004510_myositis1.37166247
70MP0000749_muscle_degeneration1.36370584
71MP0003221_abnormal_cardiomyocyte_apopto1.33424500
72MP0002398_abnormal_bone_marrow1.31366238
73MP0008469_abnormal_protein_level1.30903374
74MP0010307_abnormal_tumor_latency1.30509448
75MP0002876_abnormal_thyroid_physiology1.30054512
76MP0004742_abnormal_vestibular_system1.29949769
77MP0005310_abnormal_salivary_gland1.28595159
78MP0004859_abnormal_synaptic_plasticity1.28325077
79MP0003763_abnormal_thymus_physiology1.28212676
80MP0001764_abnormal_homeostasis1.27707357
81MP0004147_increased_porphyrin_level1.24390686
82MP0000716_abnormal_immune_system1.23520849
83* MP0000313_abnormal_cell_death1.23495298
84MP0002019_abnormal_tumor_incidence1.22701465
85MP0008569_lethality_at_weaning1.22155903
86MP0008932_abnormal_embryonic_tissue1.22152757
87MP0002396_abnormal_hematopoietic_system1.21401562
88MP0000689_abnormal_spleen_morphology1.20054018
89MP0009745_abnormal_behavioral_response1.19762580
90MP0005330_cardiomyopathy1.19593237
91MP0001984_abnormal_olfaction1.19383340
92MP0005075_abnormal_melanosome_morpholog1.18751478
93MP0001486_abnormal_startle_reflex1.18677879
94MP0000358_abnormal_cell_content/1.17370729
95MP0002254_reproductive_system_inflammat1.16744173
96MP0003195_calcinosis1.16735247
97MP0005464_abnormal_platelet_physiology1.16135322
98MP0004924_abnormal_behavior1.15796405
99MP0005386_behavior/neurological_phenoty1.15796405
100MP0000490_abnormal_crypts_of1.15279778
101MP0000003_abnormal_adipose_tissue1.14638425
102MP0005451_abnormal_body_composition1.14629420
103MP0001968_abnormal_touch/_nociception1.13822702
104MP0003724_increased_susceptibility_to1.13284482
105MP0001501_abnormal_sleep_pattern1.12279344
106MP0002229_neurodegeneration1.12181370
107MP0003075_altered_response_to1.10238077
108MP0001853_heart_inflammation1.10223250
109MP0002067_abnormal_sensory_capabilities1.09607081
110MP0000703_abnormal_thymus_morphology1.09491892
111MP0005332_abnormal_amino_acid1.09182156
112MP0004215_abnormal_myocardial_fiber1.07797422
113MP0002736_abnormal_nociception_after1.06941782
114MP0003635_abnormal_synaptic_transmissio1.06899262
115MP0004808_abnormal_hematopoietic_stem1.06871544
116MP0008872_abnormal_physiological_respon1.06561288
117MP0005025_abnormal_response_to1.05010035
118MP0008775_abnormal_heart_ventricle1.03393848
119MP0003656_abnormal_erythrocyte_physiolo1.02457372
120MP0008875_abnormal_xenobiotic_pharmacok1.01588928
121MP0000015_abnormal_ear_pigmentation1.01250764
122MP0000751_myopathy1.00915116
123MP0009785_altered_susceptibility_to0.99122359
124* MP0002429_abnormal_blood_cell0.98373739
125MP0010155_abnormal_intestine_physiology0.97251303
126MP0005452_abnormal_adipose_tissue0.96887508
127MP0002970_abnormal_white_adipose0.96475349
128MP0003950_abnormal_plasma_membrane0.96047993
129MP0005334_abnormal_fat_pad0.94703481
130MP0009333_abnormal_splenocyte_physiolog0.93600721
131MP0002722_abnormal_immune_system0.93548331
132MP0002138_abnormal_hepatobiliary_system0.93251584
133MP0003186_abnormal_redox_activity0.92269210
134MP0004084_abnormal_cardiac_muscle0.91319138
135MP0003866_abnormal_defecation0.91095742
136MP0000604_amyloidosis0.89190401
137MP0005174_abnormal_tail_pigmentation0.88117165
138MP0000350_abnormal_cell_proliferation0.87903531
139MP0008260_abnormal_autophagy0.85651012
140MP0009115_abnormal_fat_cell0.85600221
141MP0004087_abnormal_muscle_fiber0.82659365
142MP0002572_abnormal_emotion/affect_behav0.82028462
143MP0000747_muscle_weakness0.81863532
144MP0002163_abnormal_gland_morphology0.81722646
145MP0002078_abnormal_glucose_homeostasis0.81661592
146MP0002972_abnormal_cardiac_muscle0.81484940
147MP0005620_abnormal_muscle_contractility0.81249546
148MP0002118_abnormal_lipid_homeostasis0.81043756
149MP0005379_endocrine/exocrine_gland_phen0.81035185
150MP0002419_abnormal_innate_immunity0.81008138
151MP0006072_abnormal_retinal_apoptosis0.80725974
152MP0005410_abnormal_fertilization0.80064690
153MP0005319_abnormal_enzyme/_coenzyme0.80062083
154MP0009765_abnormal_xenobiotic_induced0.77059974
155MP0009763_increased_sensitivity_to0.73948962
156MP0005647_abnormal_sex_gland0.73873914
157MP0002277_abnormal_respiratory_mucosa0.73665898
158MP0001919_abnormal_reproductive_system0.72659201
159MP0001727_abnormal_embryo_implantation0.71998457
160MP0001929_abnormal_gametogenesis0.70367112
161MP0005266_abnormal_metabolism0.70191199
162MP0002693_abnormal_pancreas_physiology0.69757605
163MP0008873_increased_physiological_sensi0.69579055
164MP0000371_diluted_coat_color0.67164097
165MP0005166_decreased_susceptibility_to0.66499566
166MP0002210_abnormal_sex_determination0.65604411
167MP0001533_abnormal_skeleton_physiology0.65290847
168MP0004947_skin_inflammation0.64755806

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)4.69758183
2Hepatic necrosis (HP:0002605)4.62862977
3Hepatocellular necrosis (HP:0001404)4.48668037
4Agammaglobulinemia (HP:0004432)4.42655327
5Abnormal mitochondria in muscle tissue (HP:0008316)4.19671691
6Acute necrotizing encephalopathy (HP:0006965)4.18558300
7Increased muscle lipid content (HP:0009058)4.16529322
8Acute encephalopathy (HP:0006846)4.04604098
9Mitochondrial inheritance (HP:0001427)3.97761288
10Abnormality of glycolipid metabolism (HP:0010969)3.93226371
11Abnormality of liposaccharide metabolism (HP:0010968)3.93226371
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.93226371
13* Increased CSF lactate (HP:0002490)3.61346729
14Vacuolated lymphocytes (HP:0001922)3.59817988
15Increased serum pyruvate (HP:0003542)3.58725293
16Abnormality of glycolysis (HP:0004366)3.58725293
17Progressive macrocephaly (HP:0004481)3.53448716
18Increased intramyocellular lipid droplets (HP:0012240)3.42978149
19Abnormality of fatty-acid metabolism (HP:0004359)3.40815247
20Myoglobinuria (HP:0002913)3.35925730
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26545536
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26545536
23Abnormality of alanine metabolism (HP:0010916)3.24615876
24Hyperalaninemia (HP:0003348)3.24615876
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.24615876
26Microvesicular hepatic steatosis (HP:0001414)3.24110423
27Recurrent bronchitis (HP:0002837)3.23412597
28IgM deficiency (HP:0002850)3.21537612
29Increased cerebral lipofuscin (HP:0011813)3.20857163
30* Lactic acidosis (HP:0003128)3.20160608
31Hyperglycinuria (HP:0003108)3.15515433
32Increased neuronal autofluorescent lipopigment (HP:0002074)3.08585028
33Recurrent sinusitis (HP:0011108)3.07766400
34Dicarboxylic aciduria (HP:0003215)2.96190432
35Abnormality of dicarboxylic acid metabolism (HP:0010995)2.96190432
36Lipid accumulation in hepatocytes (HP:0006561)2.92638918
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.89708934
38Exercise-induced myalgia (HP:0003738)2.89678626
39Neuroendocrine neoplasm (HP:0100634)2.87029884
40Generalized aminoaciduria (HP:0002909)2.87026455
41Leukodystrophy (HP:0002415)2.82813339
42Oligomenorrhea (HP:0000876)2.79488110
43Pheochromocytoma (HP:0002666)2.79148022
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.74957645
45Ragged-red muscle fibers (HP:0003200)2.72672416
46Rhabdomyolysis (HP:0003201)2.71200565
47Respiratory failure (HP:0002878)2.71072569
48Abnormality of glycine metabolism (HP:0010895)2.69966302
49Abnormality of serine family amino acid metabolism (HP:0010894)2.69966302
50Increased hepatocellular lipid droplets (HP:0006565)2.68805523
51Cerebral edema (HP:0002181)2.68691363
52Multiple enchondromatosis (HP:0005701)2.67733116
53Increased serum lactate (HP:0002151)2.66973509
543-Methylglutaconic aciduria (HP:0003535)2.64732204
55Colitis (HP:0002583)2.62690787
56Panhypogammaglobulinemia (HP:0003139)2.62236040
57Progressive muscle weakness (HP:0003323)2.61661044
58Progressive inability to walk (HP:0002505)2.61069918
59IgG deficiency (HP:0004315)2.59459917
60Chromsome breakage (HP:0040012)2.55640689
61Petechiae (HP:0000967)2.54349801
62Abnormality of the preputium (HP:0100587)2.54062809
63Chronic otitis media (HP:0000389)2.53579480
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.52115881
65Reticulocytopenia (HP:0001896)2.51888968
66Type I transferrin isoform profile (HP:0003642)2.50151724
67Renal Fanconi syndrome (HP:0001994)2.49744046
68Mediastinal lymphadenopathy (HP:0100721)2.49592505
69Lymphopenia (HP:0001888)2.49023372
70Exercise intolerance (HP:0003546)2.47185069
71Obstructive lung disease (HP:0006536)2.46919599
72Chronic obstructive pulmonary disease (HP:0006510)2.46919599
73Tinnitus (HP:0000360)2.43493576
74Birth length less than 3rd percentile (HP:0003561)2.42787045
75Abnormality of macrophages (HP:0004311)2.41168376
76Focal motor seizures (HP:0011153)2.40470030
77Agnosia (HP:0010524)2.39065891
78Methylmalonic aciduria (HP:0012120)2.38706829
79Papilloma (HP:0012740)2.38055330
80Verrucae (HP:0200043)2.38055330
81Abnormal number of erythroid precursors (HP:0012131)2.37665694
82Optic disc pallor (HP:0000543)2.35889738
83Chronic sinusitis (HP:0011109)2.35820194
84Abnormality of cells of the lymphoid lineage (HP:0012140)2.35335636
85Aplasia/Hypoplasia of the sacrum (HP:0008517)2.34600925
86Recurrent bacterial skin infections (HP:0005406)2.33507283
87Recurrent viral infections (HP:0004429)2.33175036
88Nausea (HP:0002018)2.30446964
89Aplastic anemia (HP:0001915)2.29571975
90IgA deficiency (HP:0002720)2.29490431
91Recurrent abscess formation (HP:0002722)2.28849597
92Increased serum ferritin (HP:0003281)2.27849725
93Autoimmune thrombocytopenia (HP:0001973)2.27810715
94Pancytopenia (HP:0001876)2.25561265
95Stomatitis (HP:0010280)2.24931189
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.23075828
97Thyroid-stimulating hormone excess (HP:0002925)2.21924516
98Systemic lupus erythematosus (HP:0002725)2.20350651
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15337366
100Abnormal protein N-linked glycosylation (HP:0012347)2.15337366
101Abnormal protein glycosylation (HP:0012346)2.15337366
102Abnormal glycosylation (HP:0012345)2.15337366
103Cerebral hypomyelination (HP:0006808)2.15076417
104Inflammation of the large intestine (HP:0002037)2.13808674
105Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12571508
106Degeneration of the lateral corticospinal tracts (HP:0002314)2.12571508
107Abnormality of cells of the erythroid lineage (HP:0012130)2.12556417
108Abnormality of chromosome stability (HP:0003220)2.11988891
109Meckel diverticulum (HP:0002245)2.11772762
110Sensory axonal neuropathy (HP:0003390)2.11445962
111Respiratory difficulties (HP:0002880)2.11276293
112Abnormality of T cell physiology (HP:0011840)2.10619211
113Combined immunodeficiency (HP:0005387)2.10194523
114CNS demyelination (HP:0007305)2.09982576
115Aplasia/Hypoplasia of the uvula (HP:0010293)2.09862413
116Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.09175095
117Mutism (HP:0002300)2.07974553
118Central scotoma (HP:0000603)2.07667670
119Loss of speech (HP:0002371)2.07411604
120Recurrent fungal infections (HP:0002841)2.06333485
121Bone marrow hypocellularity (HP:0005528)2.05663946
122Recurrent lower respiratory tract infections (HP:0002783)2.05553892
123Reduced antithrombin III activity (HP:0001976)2.03619856
124Methylmalonic acidemia (HP:0002912)2.02868075
125Hyperventilation (HP:0002883)2.01297984
126Hypertensive crisis (HP:0100735)2.00466871
127Hepatosplenomegaly (HP:0001433)2.00431868
128Abnormality of the ileum (HP:0001549)1.99754996
129Abnormality of B cell number (HP:0010975)1.99498006
130B lymphocytopenia (HP:0010976)1.99498006
131Congenital stationary night blindness (HP:0007642)1.99401550
132Poor head control (HP:0002421)1.99122581
133Recurrent pneumonia (HP:0006532)1.98215707
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97997487
135Emphysema (HP:0002097)1.97462003
136Gastrointestinal inflammation (HP:0004386)1.96948012
137* Lethargy (HP:0001254)1.96851514
138Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.96601174
139Abnormality of the anterior horn cell (HP:0006802)1.96280839
140Degeneration of anterior horn cells (HP:0002398)1.96280839
141Neutropenia (HP:0001875)1.94294716
142Abnormal trabecular bone morphology (HP:0100671)1.94231946
143Emotional lability (HP:0000712)1.93239982
144Meningitis (HP:0001287)1.92718168
145Leukopenia (HP:0001882)1.92682615
146Hypomagnesemia (HP:0002917)1.92423716
147Exertional dyspnea (HP:0002875)1.90956214
148Cellulitis (HP:0100658)1.90229452
149Albinism (HP:0001022)1.89201305
150Cerebral hemorrhage (HP:0001342)1.88181705
151Rough bone trabeculation (HP:0100670)1.87583032
152Muscle stiffness (HP:0003552)1.87503361
153Abnormal rod and cone electroretinograms (HP:0008323)1.87472528
154Abnormality of urine glucose concentration (HP:0011016)1.86997401
155Glycosuria (HP:0003076)1.86997401
156Neoplasm of head and neck (HP:0012288)1.86802430
157Esophageal neoplasm (HP:0100751)1.86802430
158Increased IgM level (HP:0003496)1.86690105
159Hyperammonemia (HP:0001987)1.85726824
160Recurrent cutaneous fungal infections (HP:0011370)1.85527098
161Chronic mucocutaneous candidiasis (HP:0002728)1.85527098
162Recurrent otitis media (HP:0000403)1.83845704
163Myokymia (HP:0002411)1.81158599
164Abnormality of magnesium homeostasis (HP:0004921)1.80469298

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.73474632
2VRK23.41803587
3CDC73.13519253
4PDK33.07514959
5PDK43.07514959
6BCKDK3.07346940
7OXSR13.01118577
8PBK2.68212327
9BLK2.24106760
10SYK2.10393138
11SRPK12.08512596
12CSF1R2.07750201
13STK392.05332127
14ZAK2.05226608
15CDK192.04285652
16PIM21.94140686
17PRKCH1.72995616
18MATK1.72916509
19PINK11.68704456
20TTK1.62997867
21VRK11.62802183
22MAP3K131.51017496
23TSSK61.50696654
24PDK21.49975775
25TLK11.49775030
26PLK41.48592009
27CAMK1D1.46927477
28WNK41.46387432
29BMPR21.42096551
30BUB11.41895496
31ARAF1.41793917
32CASK1.40960852
33LMTK21.40128403
34JAK31.39021795
35MAP3K141.37643042
36MAP3K111.37638590
37PHKG11.37369350
38PHKG21.37369350
39PRPF4B1.36648101
40BTK1.35145799
41CCNB11.33588452
42IRAK41.33202747
43KIT1.32626400
44NME21.31272078
45ABL21.30562468
46NUAK11.29874033
47OBSCN1.28045319
48NEK11.27379865
49PKN11.24402879
50PRKCQ1.18918205
51CDK41.17976270
52MAP2K71.17279702
53ATR1.16208255
54SGK2231.15438092
55SGK4941.15438092
56FES1.14846145
57PDK11.13869364
58SIK31.11946491
59EIF2AK11.11806863
60ACVR1B1.11608996
61JAK11.10868130
62SIK21.10373086
63TXK1.08417925
64CHEK21.07415752
65GRK51.06347460
66LYN1.04800456
67CSNK1G31.04238015
68PLK11.03948379
69GRK71.03097784
70NME11.02723928
71MAP2K31.01897734
72SMG11.01623240
73DAPK10.98705669
74KDR0.96728294
75WEE10.94575405
76RIPK40.92855800
77GRK60.92559083
78TNIK0.90806681
79TAOK20.88582182
80BRAF0.87802952
81PTK2B0.85982639
82IKBKB0.84882438
83TAOK30.84866688
84AURKA0.84492229
85MAP3K80.82311596
86TRIM280.81523852
87CAMK1G0.81513313
88STK160.78340978
89TESK20.78161764
90LCK0.76241369
91PIM10.76161882
92CSNK1G10.75762467
93PLK30.74968688
94TRIB30.74160309
95SGK20.73602939
96AURKB0.73135825
97CHEK10.72970586
98RPS6KB20.72952210
99EIF2AK30.72700455
100TBK10.71821077
101MAPK110.71780835
102PAK60.70210770
103PDPK10.69628260
104STK40.68129813
105SIK10.67902638
106SGK30.65558154
107CLK10.65177100
108EPHB10.64477097
109WNK10.64462590
110CDK70.63171647
111RPS6KA50.62114694
112STK240.61784748
113CSNK1G20.61264353
114MAPK120.60727050
115ALK0.60667594
116PRKAA20.59614452
117MAP3K70.59183981
118ZAP700.58270626
119CSNK2A10.57837058
120IRAK30.57807822
121RPS6KA40.55239919
122BRSK20.55055434
123CSNK1A1L0.54206338
124EIF2AK20.51195455
125MARK30.51015145
126MAPKAPK30.49591759
127MST40.49190036
128MKNK10.49109867
129TEC0.48580989
130TGFBR10.47986960
131CDK50.47924174
132MAPK70.47272453
133CDK80.46687982
134CSNK2A20.45920802
135STK100.45731213
136TYK20.45338892
137MAP2K60.45066829
138CAMK10.45035465
139ATM0.44994153
140MAP4K20.44168437
141ERN10.43260868
142HCK0.42183597
143IKBKE0.41898904
144ADRBK20.40856324
145PRKCD0.40520929
146PRKD20.40379607
147TNK20.39916440
148GRK10.39507185
149ITK0.39437444
150FGR0.39310330
151MAPKAPK50.38986732
152LIMK10.38312348
153JAK20.37807371
154CDK30.37770798
155RAF10.37302210
156BMPR1B0.37253159
157BCR0.37244343
158PAK10.37180091
159WNK30.36572978
160CHUK0.36154775
161BRSK10.35491940
162MAP3K120.35428179

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.19621199
2Propanoate metabolism_Homo sapiens_hsa006404.06017425
3Oxidative phosphorylation_Homo sapiens_hsa001903.64674511
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.49097794
5Primary immunodeficiency_Homo sapiens_hsa053403.40064060
6Parkinsons disease_Homo sapiens_hsa050123.27600892
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01229679
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.78247907
9Alzheimers disease_Homo sapiens_hsa050102.48718485
10Fatty acid metabolism_Homo sapiens_hsa012122.38506869
11Fatty acid degradation_Homo sapiens_hsa000712.26209978
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.25267153
13Pyruvate metabolism_Homo sapiens_hsa006202.24222588
14Fatty acid elongation_Homo sapiens_hsa000622.23514937
15Huntingtons disease_Homo sapiens_hsa050162.11710086
16Carbon metabolism_Homo sapiens_hsa012002.08859468
17B cell receptor signaling pathway_Homo sapiens_hsa046622.02042002
18Fatty acid biosynthesis_Homo sapiens_hsa000611.93078543
19Spliceosome_Homo sapiens_hsa030401.92251256
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86860723
21Fanconi anemia pathway_Homo sapiens_hsa034601.82849270
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.78399178
23One carbon pool by folate_Homo sapiens_hsa006701.70026641
24Cardiac muscle contraction_Homo sapiens_hsa042601.68994801
25Nucleotide excision repair_Homo sapiens_hsa034201.65223956
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62985800
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.60111460
28Other glycan degradation_Homo sapiens_hsa005111.56992199
29RNA transport_Homo sapiens_hsa030131.53262947
30Lysosome_Homo sapiens_hsa041421.42949708
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42741591
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.40273575
33Antigen processing and presentation_Homo sapiens_hsa046121.35659736
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32197977
35PPAR signaling pathway_Homo sapiens_hsa033201.30903707
36Graft-versus-host disease_Homo sapiens_hsa053321.30092985
37Butanoate metabolism_Homo sapiens_hsa006501.28875652
38Type I diabetes mellitus_Homo sapiens_hsa049401.23370117
39RNA polymerase_Homo sapiens_hsa030201.23167458
40Proteasome_Homo sapiens_hsa030501.22509337
41Collecting duct acid secretion_Homo sapiens_hsa049661.17778900
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14858581
43Staphylococcus aureus infection_Homo sapiens_hsa051501.14723091
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13176788
45Legionellosis_Homo sapiens_hsa051341.12824352
46Vitamin B6 metabolism_Homo sapiens_hsa007501.11737904
47Pentose phosphate pathway_Homo sapiens_hsa000301.11310149
48Phototransduction_Homo sapiens_hsa047441.10152201
49Leishmaniasis_Homo sapiens_hsa051401.09745523
50Glycerolipid metabolism_Homo sapiens_hsa005611.04624788
51Cell cycle_Homo sapiens_hsa041101.03012227
52Sulfur metabolism_Homo sapiens_hsa009201.01526647
53beta-Alanine metabolism_Homo sapiens_hsa004101.00953095
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.00775648
55Herpes simplex infection_Homo sapiens_hsa051680.99942539
56Peroxisome_Homo sapiens_hsa041460.99911918
57Biosynthesis of amino acids_Homo sapiens_hsa012300.98376244
58Epstein-Barr virus infection_Homo sapiens_hsa051690.98143856
59Base excision repair_Homo sapiens_hsa034100.97274745
60Systemic lupus erythematosus_Homo sapiens_hsa053220.96721614
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95643064
62Basal transcription factors_Homo sapiens_hsa030220.95242437
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93767817
64Synaptic vesicle cycle_Homo sapiens_hsa047210.92724602
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88171638
66Morphine addiction_Homo sapiens_hsa050320.83563976
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83098098
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82985394
69Tuberculosis_Homo sapiens_hsa051520.82069591
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82063388
71Glutathione metabolism_Homo sapiens_hsa004800.82052767
72Osteoclast differentiation_Homo sapiens_hsa043800.71680656
73Hematopoietic cell lineage_Homo sapiens_hsa046400.69199119
74Sulfur relay system_Homo sapiens_hsa041220.69107088
75Autoimmune thyroid disease_Homo sapiens_hsa053200.68918416
76Selenocompound metabolism_Homo sapiens_hsa004500.68704773
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68152763
78T cell receptor signaling pathway_Homo sapiens_hsa046600.66835843
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.66571689
80Folate biosynthesis_Homo sapiens_hsa007900.66368174
81Fructose and mannose metabolism_Homo sapiens_hsa000510.65383799
82Influenza A_Homo sapiens_hsa051640.64401848
83Homologous recombination_Homo sapiens_hsa034400.63861975
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.63704250
85Ribosome_Homo sapiens_hsa030100.60445520
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59319178
87Metabolic pathways_Homo sapiens_hsa011000.58847800
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57485493
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57350301
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56379430
91Pertussis_Homo sapiens_hsa051330.55362778
92Apoptosis_Homo sapiens_hsa042100.53514767
93Olfactory transduction_Homo sapiens_hsa047400.52854173
94Calcium signaling pathway_Homo sapiens_hsa040200.51328797
95Viral myocarditis_Homo sapiens_hsa054160.51171613
96Renin secretion_Homo sapiens_hsa049240.50739156
97Purine metabolism_Homo sapiens_hsa002300.49814249
98Nicotine addiction_Homo sapiens_hsa050330.48451534
99Salivary secretion_Homo sapiens_hsa049700.48081620
100TNF signaling pathway_Homo sapiens_hsa046680.47951189
101mRNA surveillance pathway_Homo sapiens_hsa030150.47415642
102GABAergic synapse_Homo sapiens_hsa047270.46893935
103DNA replication_Homo sapiens_hsa030300.46469665
104Circadian entrainment_Homo sapiens_hsa047130.46131842
105Chemokine signaling pathway_Homo sapiens_hsa040620.45887366
106Asthma_Homo sapiens_hsa053100.45776672
107Mismatch repair_Homo sapiens_hsa034300.45165972
108Sphingolipid metabolism_Homo sapiens_hsa006000.44976784
109Insulin signaling pathway_Homo sapiens_hsa049100.44592784
110N-Glycan biosynthesis_Homo sapiens_hsa005100.42895776
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42035975
112Protein export_Homo sapiens_hsa030600.41991834
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41899681
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41768542
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.41599315
116p53 signaling pathway_Homo sapiens_hsa041150.41572158
117Phagosome_Homo sapiens_hsa041450.41279502
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41134184
119Steroid biosynthesis_Homo sapiens_hsa001000.40972838
120Toxoplasmosis_Homo sapiens_hsa051450.40838894
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40640139
122Shigellosis_Homo sapiens_hsa051310.40149557
123Allograft rejection_Homo sapiens_hsa053300.40052828
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38476724
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.38054998
126Bladder cancer_Homo sapiens_hsa052190.37284248
127Glutamatergic synapse_Homo sapiens_hsa047240.36873976
128Viral carcinogenesis_Homo sapiens_hsa052030.36461042
129Vibrio cholerae infection_Homo sapiens_hsa051100.36134556
130AMPK signaling pathway_Homo sapiens_hsa041520.35941937
131Galactose metabolism_Homo sapiens_hsa000520.35890721
132HTLV-I infection_Homo sapiens_hsa051660.35720336
133Rheumatoid arthritis_Homo sapiens_hsa053230.32961254
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30494514
135Glucagon signaling pathway_Homo sapiens_hsa049220.30263644
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.30214305
137Regulation of autophagy_Homo sapiens_hsa041400.29876360
138Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29809552
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29743638
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29456761
141Inositol phosphate metabolism_Homo sapiens_hsa005620.28270541
142Taste transduction_Homo sapiens_hsa047420.26606555
143Pyrimidine metabolism_Homo sapiens_hsa002400.25939958
144Ether lipid metabolism_Homo sapiens_hsa005650.23994300
145Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22002938
146Long-term depression_Homo sapiens_hsa047300.20665257
147Measles_Homo sapiens_hsa051620.20263364
148Non-homologous end-joining_Homo sapiens_hsa034500.19807255
149Long-term potentiation_Homo sapiens_hsa047200.18051381
150Cyanoamino acid metabolism_Homo sapiens_hsa004600.18047551
151Cholinergic synapse_Homo sapiens_hsa047250.17206506
152cAMP signaling pathway_Homo sapiens_hsa040240.16739767
153RNA degradation_Homo sapiens_hsa030180.15871125
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15393856
155Serotonergic synapse_Homo sapiens_hsa047260.15136389

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