ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	peptidyl-arginine omega-N-methylation (GO:0035247)	4.92083630
2	establishment of integrated proviral latency (GO:0075713)	4.71280517
3	cullin deneddylation (GO:0010388)	4.61784421
4	protein deneddylation (GO:0000338)	4.58343204
5	viral mRNA export from host cell nucleus (GO:0046784)	4.39889167
6	establishment of viral latency (GO:0019043)	4.30686251
7	COPI coating of Golgi vesicle (GO:0048205)	4.22645168
8	Golgi transport vesicle coating (GO:0048200)	4.22645168
9	peptidyl-arginine methylation (GO:0018216)	4.18355561
10	peptidyl-arginine N-methylation (GO:0035246)	4.18355561
11	histone arginine methylation (GO:0034969)	4.11674235
12	de novo posttranslational protein folding (GO:0051084)	3.87477535
13	positive regulation of mitochondrial fission (GO:0090141)	3.85148855
14	de novo protein folding (GO:0006458)	3.82142834
15	DNA strand elongation involved in DNA replication (GO:0006271)	3.73839845
16	metallo-sulfur cluster assembly (GO:0031163)	3.72909575
17	iron-sulfur cluster assembly (GO:0016226)	3.72909575
18	DNA strand elongation (GO:0022616)	3.70622807
19	protein maturation by protein folding (GO:0022417)	3.69818074
20	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.65569685
21	formation of translation preinitiation complex (GO:0001731)	3.61680676
22	mitochondrial fusion (GO:0008053)	3.58601458
23	DNA ligation (GO:0006266)	3.56550832
24	tRNA methylation (GO:0030488)	3.55273815
25	tRNA aminoacylation for protein translation (GO:0006418)	3.51076816
26	proteasome assembly (GO:0043248)	3.47848120
27	proline biosynthetic process (GO:0006561)	3.46881352
28	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.44931088
29	negative regulation of ligase activity (GO:0051352)	3.44448411
30	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.44448411
31	amino acid activation (GO:0043038)	3.43967369
32	tRNA aminoacylation (GO:0043039)	3.43967369
33	ribosome assembly (GO:0042255)	3.43398886
34	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.41742144
35	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.40877948
36	glycolytic process (GO:0006096)	3.37216828
37	DNA unwinding involved in DNA replication (GO:0006268)	3.35599092
38	telomere maintenance via semi-conservative replication (GO:0032201)	3.31047523
39	DNA replication initiation (GO:0006270)	3.23441239
40	mitotic nuclear envelope reassembly (GO:0007084)	3.22086054
41	nuclear envelope reassembly (GO:0031468)	3.22086054
42	pentose-phosphate shunt (GO:0006098)	3.19502595
43	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.13975391
44	spliceosomal snRNP assembly (GO:0000387)	3.10944357
45	mitotic metaphase plate congression (GO:0007080)	3.07544320
46	NADPH regeneration (GO:0006740)	3.06920678
47	mitotic nuclear envelope disassembly (GO:0007077)	3.04336404
48	IMP biosynthetic process (GO:0006188)	3.00010221
49	nucleobase-containing small molecule interconversion (GO:0015949)	2.96293667
50	L-serine metabolic process (GO:0006563)	2.95808434
51	positive regulation of ligase activity (GO:0051351)	2.95343791
52	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.91382728
53	regulation of spindle organization (GO:0090224)	2.91258382
54	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.90245273
55	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.87977224
56	ncRNA 3-end processing (GO:0043628)	2.84648941
57	regulation of cellular amino acid metabolic process (GO:0006521)	2.84452402
58	dosage compensation (GO:0007549)	2.84368181
59	regulation of mitochondrial translation (GO:0070129)	2.84324383
60	maturation of 5.8S rRNA (GO:0000460)	2.82666477
61	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.80620405
62	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.80262600
63	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.80262600
64	rRNA modification (GO:0000154)	2.79438535
65	tricarboxylic acid cycle (GO:0006099)	2.79300732
66	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.79264426
67	ribosome biogenesis (GO:0042254)	2.77756399
68	polyamine biosynthetic process (GO:0006596)	2.77596998
69	nuclear envelope disassembly (GO:0051081)	2.76482537
70	membrane disassembly (GO:0030397)	2.76482537
71	UV protection (GO:0009650)	2.76465288
72	regulation of ligase activity (GO:0051340)	2.75508591
73	tRNA modification (GO:0006400)	2.74819002
74	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.74596537
75	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.74596537
76	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.74596537
77	mitochondrial DNA metabolic process (GO:0032042)	2.74254360
78	base-excision repair (GO:0006284)	2.74245620
79	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.73983779
80	regulation of mitotic spindle organization (GO:0060236)	2.73761194
81	purine ribonucleotide transport (GO:0015868)	2.73173115
82	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.72580974
83	regulation of translational fidelity (GO:0006450)	2.71569347
84	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.71552637
85	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.71517315
86	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.71457522
87	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.71457522
88	DNA double-strand break processing (GO:0000729)	2.70724905
89	monosaccharide biosynthetic process (GO:0046364)	2.70342785
90	snRNA processing (GO:0016180)	2.69329230
91	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.69110095
92	gluconeogenesis (GO:0006094)	2.66929615
93	telomere maintenance via recombination (GO:0000722)	2.65020237
94	lipopolysaccharide biosynthetic process (GO:0009103)	2.64934776
95	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.63661491
96	DNA catabolic process, exonucleolytic (GO:0000738)	2.63659716
97	7-methylguanosine mRNA capping (GO:0006370)	2.63584128
98	regulation of coenzyme metabolic process (GO:0051196)	2.63213798
99	regulation of cofactor metabolic process (GO:0051193)	2.63213798
100	base-excision repair, AP site formation (GO:0006285)	2.61596042

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.35483665
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.80770402
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.75596780
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.69010802
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.57338457
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.48855307
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.46416032
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.12132844
9	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.10879722
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.91372087
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.81529698
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.69753777
13	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.69538533
14	DCP1A_22483619_ChIP-Seq_HELA_Human	2.53232633
15	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.51197221
16	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.47552825
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.45052381
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.39778541
19	XRN2_22483619_ChIP-Seq_HELA_Human	2.39165586
20	GABP_19822575_ChIP-Seq_HepG2_Human	2.34861202
21	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	2.25605233
22	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.21518343
23	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.17164838
24	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.12457548
25	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.12338702
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12177664
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.08754394
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.05425772
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.05414257
30	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	2.03770761
31	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.02067937
32	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.00736900
33	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.99791415
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.91492550
35	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.91163924
36	CIITA_25753668_ChIP-Seq_RAJI_Human	1.89418906
37	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.85834873
38	FOXP3_21729870_ChIP-Seq_TREG_Human	1.85822977
39	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.85087403
40	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.84675782
41	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.81995515
42	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.75829506
43	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.75730380
44	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.74528058
45	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.74485083
46	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.72645667
47	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.66165337
48	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.64989770
49	TTF2_22483619_ChIP-Seq_HELA_Human	1.63248554
50	KDM5A_27292631_Chip-Seq_BREAST_Human	1.60203726
51	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.57888303
52	MYC_22102868_ChIP-Seq_BL_Human	1.54009216
53	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53601960
54	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.50185532
55	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.49909130
56	VDR_21846776_ChIP-Seq_THP-1_Human	1.47677050
57	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.44629469
58	TFEB_21752829_ChIP-Seq_HELA_Human	1.40614436
59	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.36760606
60	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.33087011
61	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32595521
62	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.32237809
63	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.31288628
64	ZNF263_19887448_ChIP-Seq_K562_Human	1.30624730
65	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.29519220
66	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.27292617
67	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.27076421
68	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.20996443
69	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.19920918
70	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.19875235
71	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.19835365
72	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.18251380
73	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17937594
74	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.17866141
75	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.17339890
76	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.14892016
77	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.09651528
78	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.06507418
79	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.04027152
80	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.03981575
81	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.03246464
82	AR_21909140_ChIP-Seq_LNCAP_Human	1.03032527
83	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.02016158
84	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.01490156
85	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.00646634
86	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.99612095
87	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.98584862
88	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.98549565
89	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.97692641
90	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.96801823
91	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.96018493
92	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.94581632
93	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.94062543
94	SPI1_23547873_ChIP-Seq_NB4_Human	0.93047325
95	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.92634974
96	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.92449501
97	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.91883790
98	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.88892822
99	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.87526845
100	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.86750744

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	4.85150229
2	MP0010094_abnormal_chromosome_stability	4.47995270
3	MP0008058_abnormal_DNA_repair	4.15509427
4	MP0003111_abnormal_nucleus_morphology	3.73412995
5	MP0003693_abnormal_embryo_hatching	3.47692869
6	MP0003221_abnormal_cardiomyocyte_apopto	3.27672459
7	MP0003077_abnormal_cell_cycle	3.08119844
8	MP0006035_abnormal_mitochondrial_morpho	2.95522444
9	MP0003806_abnormal_nucleotide_metabolis	2.83550898
10	MP0001529_abnormal_vocalization	2.77348139
11	MP0008007_abnormal_cellular_replicative	2.58835904
12	MP0008932_abnormal_embryonic_tissue	2.55371486
13	MP0009697_abnormal_copulation	2.52888424
14	MP0008260_abnormal_autophagy	2.46751821
15	MP0003656_abnormal_erythrocyte_physiolo	2.24281836
16	MP0000358_abnormal_cell_content/	2.13320011
17	MP0008789_abnormal_olfactory_epithelium	2.09029544
18	MP0005394_taste/olfaction_phenotype	2.08841481
19	MP0005499_abnormal_olfactory_system	2.08841481
20	MP0003786_premature_aging	2.07946787
21	MP0006036_abnormal_mitochondrial_physio	2.06877094
22	MP0004957_abnormal_blastocyst_morpholog	2.02290134
23	MP0005058_abnormal_lysosome_morphology	1.93735777
24	MP0001730_embryonic_growth_arrest	1.80226273
25	MP0000749_muscle_degeneration	1.67894702
26	MP0003186_abnormal_redox_activity	1.67458456
27	MP0004233_abnormal_muscle_weight	1.65787305
28	MP0000350_abnormal_cell_proliferation	1.57925638
29	MP0002877_abnormal_melanocyte_morpholog	1.56889847
30	MP0000313_abnormal_cell_death	1.54640808
31	MP0009333_abnormal_splenocyte_physiolog	1.51764430
32	MP0005330_cardiomyopathy	1.49773254
33	MP0001727_abnormal_embryo_implantation	1.49715203
34	MP0000751_myopathy	1.47878163
35	MP0003315_abnormal_perineum_morphology	1.45972162
36	MP0002080_prenatal_lethality	1.38492113
37	MP0001849_ear_inflammation	1.38282381
38	MP0003191_abnormal_cellular_cholesterol	1.38113473
39	MP0002269_muscular_atrophy	1.28689758
40	MP0000750_abnormal_muscle_regeneration	1.26771489
41	MP0005384_cellular_phenotype	1.22987731
42	MP0009840_abnormal_foam_cell	1.18611954
43	MP0001661_extended_life_span	1.13777428
44	MP0005501_abnormal_skin_physiology	1.13020143
45	MP0000747_muscle_weakness	1.12342627
46	MP0002653_abnormal_ependyma_morphology	1.11143023
47	MP0005380_embryogenesis_phenotype	1.10354046
48	MP0001672_abnormal_embryogenesis/_devel	1.10354046
49	MP0003718_maternal_effect	1.08104790
50	MP0002019_abnormal_tumor_incidence	1.07503831
51	MP0001764_abnormal_homeostasis	1.07241732
52	MP0005621_abnormal_cell_physiology	1.06280405
53	MP0002332_abnormal_exercise_endurance	1.04705454
54	MP0003329_amyloid_beta_deposits	1.04523019
55	MP0009278_abnormal_bone_marrow	1.04297718
56	MP0000343_altered_response_to	1.03962600
57	MP0000604_amyloidosis	0.96078388
58	MP0001853_heart_inflammation	0.90208748
59	MP0003984_embryonic_growth_retardation	0.89742714
60	MP0003137_abnormal_impulse_conducting	0.87008890
61	MP0000490_abnormal_crypts_of	0.85336972
62	MP0001270_distended_abdomen	0.82632312
63	MP0002396_abnormal_hematopoietic_system	0.80779049
64	MP0001697_abnormal_embryo_size	0.78626519
65	MP0002088_abnormal_embryonic_growth/wei	0.78229804
66	MP0002090_abnormal_vision	0.78204819
67	MP0005623_abnormal_meninges_morphology	0.78189804
68	MP0005266_abnormal_metabolism	0.78168918
69	MP0002132_abnormal_respiratory_system	0.77543898
70	MP0001545_abnormal_hematopoietic_system	0.77259622
71	MP0005397_hematopoietic_system_phenotyp	0.77259622
72	MP0000858_altered_metastatic_potential	0.76219080
73	MP0002722_abnormal_immune_system	0.75448077
74	MP0003303_peritoneal_inflammation	0.73264438
75	MP0005584_abnormal_enzyme/coenzyme_acti	0.72426302
76	MP0005187_abnormal_penis_morphology	0.70733247
77	MP0003385_abnormal_body_wall	0.70479479
78	MP0009763_increased_sensitivity_to	0.68982732
79	MP0000689_abnormal_spleen_morphology	0.68062169
80	MP0002970_abnormal_white_adipose	0.67601140
81	MP0010307_abnormal_tumor_latency	0.66847118
82	MP0000372_irregular_coat_pigmentation	0.64894575
83	MP0002085_abnormal_embryonic_tissue	0.62915232
84	MP0008873_increased_physiological_sensi	0.62827925
85	MP0006082_CNS_inflammation	0.61987027
86	MP0005645_abnormal_hypothalamus_physiol	0.61833242
87	MP0002084_abnormal_developmental_patter	0.60512020
88	MP0001915_intracranial_hemorrhage	0.59759893
89	MP0005165_increased_susceptibility_to	0.59249780
90	MP0001243_abnormal_dermal_layer	0.58429747
91	MP0002086_abnormal_extraembryonic_tissu	0.58335828
92	MP0000759_abnormal_skeletal_muscle	0.58297303
93	MP0004197_abnormal_fetal_growth/weight/	0.57902175
94	MP0002429_abnormal_blood_cell	0.55899377
95	MP0002751_abnormal_autonomic_nervous	0.55797594
96	MP0005319_abnormal_enzyme/_coenzyme	0.55505692
97	MP0000598_abnormal_liver_morphology	0.55130415
98	MP0004808_abnormal_hematopoietic_stem	0.55098281
99	MP0005423_abnormal_somatic_nervous	0.54737101
100	MP0009785_altered_susceptibility_to	0.54514805

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Microvesicular hepatic steatosis (HP:0001414)	4.75675045
2	Cholecystitis (HP:0001082)	4.51534807
3	Abnormal gallbladder physiology (HP:0012438)	4.51534807
4	Abnormality of glycolysis (HP:0004366)	4.06473265
5	Progressive external ophthalmoplegia (HP:0000590)	3.99016692
6	Cortical dysplasia (HP:0002539)	3.75168741
7	Increased serum pyruvate (HP:0003542)	3.72344123
8	Ragged-red muscle fibers (HP:0003200)	3.65212960
9	Progressive muscle weakness (HP:0003323)	3.64822084
10	Abnormality of the anterior horn cell (HP:0006802)	3.34683674
11	Degeneration of anterior horn cells (HP:0002398)	3.34683674
12	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.99912103
13	Reticulocytosis (HP:0001923)	2.80761370
14	Squamous cell carcinoma (HP:0002860)	2.67896394
15	Exercise-induced muscle cramps (HP:0003710)	2.63604094
16	Termporal pattern (HP:0011008)	2.57910146
17	Insidious onset (HP:0003587)	2.57910146
18	Loss of speech (HP:0002371)	2.57727865
19	Abnormal protein N-linked glycosylation (HP:0012347)	2.57478925
20	Abnormal protein glycosylation (HP:0012346)	2.57478925
21	Abnormal glycosylation (HP:0012345)	2.57478925
22	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.57478925
23	Reduced antithrombin III activity (HP:0001976)	2.57428752
24	Type I transferrin isoform profile (HP:0003642)	2.56423905
25	Cholelithiasis (HP:0001081)	2.53806698
26	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.52649976
27	Abnormal number of erythroid precursors (HP:0012131)	2.50845940
28	Rough bone trabeculation (HP:0100670)	2.50121476
29	Hepatocellular necrosis (HP:0001404)	2.48865232
30	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.41601150
31	Autoamputation (HP:0001218)	2.40175765
32	Increased intramyocellular lipid droplets (HP:0012240)	2.38827953
33	Abnormality of the motor neurons (HP:0002450)	2.37958754
34	Abnormal neuron morphology (HP:0012757)	2.37958754
35	Exercise intolerance (HP:0003546)	2.36270557
36	Abnormality of alanine metabolism (HP:0010916)	2.32184904
37	Hyperalaninemia (HP:0003348)	2.32184904
38	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32184904
39	Increased serum lactate (HP:0002151)	2.29413511
40	Increased muscle lipid content (HP:0009058)	2.24306837
41	Poikiloderma (HP:0001029)	2.22787878
42	Retinal dysplasia (HP:0007973)	2.22315294
43	Upper limb muscle weakness (HP:0003484)	2.21415002
44	Thoracic kyphosis (HP:0002942)	2.21281699
45	Hepatic necrosis (HP:0002605)	2.20626805
46	Entropion (HP:0000621)	2.18512162
47	Abnormal mitochondria in muscle tissue (HP:0008316)	2.17545739
48	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.15127856
49	Abnormal gallbladder morphology (HP:0012437)	2.14900068
50	High anterior hairline (HP:0009890)	2.14159575
51	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.13234538
52	Lactic acidosis (HP:0003128)	2.12785104
53	Progressive hearing impairment (HP:0001730)	2.12589362
54	Postnatal microcephaly (HP:0005484)	2.11421237
55	Hyperacusis (HP:0010780)	2.10599934
56	Diminished motivation (HP:0000745)	2.10216240
57	Emotional lability (HP:0000712)	2.04828978
58	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.02441852
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.02441852
60	Abnormality of reticulocytes (HP:0004312)	2.02366070
61	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.01526013
62	Athetosis (HP:0002305)	2.00467736
63	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.00353551
64	Apathy (HP:0000741)	1.99076310
65	Insomnia (HP:0100785)	1.97199119
66	Esophageal neoplasm (HP:0100751)	1.96247664
67	Neoplasm of head and neck (HP:0012288)	1.96247664
68	Myoglobinuria (HP:0002913)	1.94502337
69	Rhabdomyolysis (HP:0003201)	1.94046892
70	Combined immunodeficiency (HP:0005387)	1.93667612
71	Opisthotonus (HP:0002179)	1.92574475
72	Abnormality of fatty-acid metabolism (HP:0004359)	1.91127521
73	Abnormal trabecular bone morphology (HP:0100671)	1.91021866
74	Sensory axonal neuropathy (HP:0003390)	1.90214914
75	Hypoplasia of the brainstem (HP:0002365)	1.87711633
76	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.87711633
77	Neuronal loss in central nervous system (HP:0002529)	1.85924044
78	Upper motor neuron abnormality (HP:0002127)	1.85894204
79	Multiple enchondromatosis (HP:0005701)	1.84512350
80	Death in infancy (HP:0001522)	1.84403360
81	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.82571860
82	Hand muscle atrophy (HP:0009130)	1.81505312
83	Severe combined immunodeficiency (HP:0004430)	1.79901557
84	Abnormality of cells of the erythroid lineage (HP:0012130)	1.79387940
85	Limb-girdle muscle atrophy (HP:0003797)	1.78370138
86	Prolonged neonatal jaundice (HP:0006579)	1.77487697
87	Abnormality of liposaccharide metabolism (HP:0010968)	1.74984801
88	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.74984801
89	Abnormality of glycolipid metabolism (HP:0010969)	1.74984801
90	Hepatosplenomegaly (HP:0001433)	1.72706955
91	Secondary amenorrhea (HP:0000869)	1.71746867
92	Aplastic anemia (HP:0001915)	1.70338763
93	Abnormality of the columella (HP:0009929)	1.69739555
94	Mitochondrial inheritance (HP:0001427)	1.69147743
95	Increased CSF lactate (HP:0002490)	1.67735613
96	Upper limb amyotrophy (HP:0009129)	1.67711684
97	Distal upper limb amyotrophy (HP:0007149)	1.67711684
98	Abnormality of the gallbladder (HP:0005264)	1.66354029
99	Hyperammonemia (HP:0001987)	1.66047511
100	Progressive microcephaly (HP:0000253)	1.64955052

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	4.28650298
2	PIM2	3.44879398
3	PBK	3.40987465
4	VRK2	3.34118851
5	MAP4K2	2.95949774
6	BCKDK	2.90589444
7	BUB1	2.80144383
8	TESK2	2.65624484
9	ARAF	2.41870584
10	TSSK6	2.25683495
11	MAP2K7	2.13251344
12	BCR	2.10480941
13	NEK1	2.09799797
14	CSNK1G3	2.05740760
15	SRPK1	2.04884902
16	LIMK1	1.94640961
17	TESK1	1.90010987
18	IRAK3	1.89812365
19	CSNK1A1L	1.86911447
20	SIK3	1.83875322
21	TRIM28	1.82828834
22	RAF1	1.76480763
23	SMG1	1.75473425
24	CLK1	1.67364024
25	RPS6KA4	1.62095819
26	CCNB1	1.61727352
27	CSNK1G2	1.31785306
28	CSNK1G1	1.27876539
29	SCYL2	1.26888299
30	FLT3	1.25521585
31	TTK	1.23505031
32	DAPK1	1.23362433
33	VRK1	1.20963139
34	PKN2	1.20463724
35	EIF2AK1	1.19442848
36	CDC7	1.15316838
37	ICK	1.12903347
38	DYRK3	1.12137607
39	PAK4	1.11119280
40	MAP3K4	1.10575837
41	ATR	1.08659654
42	PAK6	1.07155237
43	ERBB3	1.03089893
44	KSR2	1.00743589
45	AURKA	0.99906565
46	BRAF	0.91486559
47	KDR	0.87059742
48	ERN1	0.86511558
49	PLK1	0.85349791
50	CDK14	0.81795180
51	STK10	0.81522664
52	KSR1	0.80836745
53	CDK7	0.75292281
54	AURKB	0.71524294
55	CDK18	0.69612482
56	MAP3K8	0.67481614
57	PDK2	0.67125722
58	PRPF4B	0.66541866
59	TAOK2	0.64000795
60	PAK2	0.63520452
61	CDK11A	0.62937461
62	RPS6KA5	0.61938502
63	CDK15	0.61536491
64	CHEK1	0.61218678
65	LMTK2	0.60544577
66	MAP3K5	0.60387040
67	AKT2	0.59941006
68	MST4	0.56781956
69	PAK1	0.54743429
70	PLK3	0.53186761
71	ABL2	0.52105294
72	CDK4	0.49698172
73	MST1R	0.49075152
74	BRSK1	0.47795201
75	PLK4	0.47317523
76	ATM	0.44197063
77	EPHA3	0.43963007
78	BRD4	0.43509050
79	CDK9	0.41657943
80	MAP3K10	0.41469741
81	EPHA2	0.41240995
82	DAPK3	0.40690300
83	PINK1	0.40551407
84	MOS	0.38690063
85	MAP3K11	0.38536964
86	TTN	0.36525913
87	PRKCI	0.35514141
88	LRRK2	0.34862976
89	IRAK4	0.34776314
90	EIF2AK3	0.34318964
91	CSNK2A1	0.33853125
92	TAOK3	0.32956563
93	CHEK2	0.32672946
94	NEK9	0.30639072
95	MAPK11	0.28681486
96	CDK2	0.28345063
97	BLK	0.28235169
98	CDK6	0.26563498
99	CSNK2A2	0.25942005
100	MARK3	0.25562385

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.64246008
2	Proteasome_Homo sapiens_hsa03050	3.35758101
3	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.26793765
4	Base excision repair_Homo sapiens_hsa03410	3.23346027
5	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.80086961
6	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.71970251
7	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.66438848
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.56639001
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.55940028
10	Mismatch repair_Homo sapiens_hsa03430	2.39362135
11	Carbon metabolism_Homo sapiens_hsa01200	2.28551408
12	Spliceosome_Homo sapiens_hsa03040	2.24588087
13	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.07425178
14	RNA transport_Homo sapiens_hsa03013	2.04352759
15	Pentose phosphate pathway_Homo sapiens_hsa00030	2.02587612
16	RNA polymerase_Homo sapiens_hsa03020	2.00548005
17	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.99534839
18	Fatty acid elongation_Homo sapiens_hsa00062	1.97351254
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.87753320
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.82581083
21	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.64083696
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.61809687
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.56818587
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.56275297
25	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.55778726
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.54872645
27	Homologous recombination_Homo sapiens_hsa03440	1.54857143
28	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.54571975
29	Sulfur relay system_Homo sapiens_hsa04122	1.53702847
30	Cell cycle_Homo sapiens_hsa04110	1.51945996
31	Pyruvate metabolism_Homo sapiens_hsa00620	1.48075416
32	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.44701805
33	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.40302644
34	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.30950314
35	mRNA surveillance pathway_Homo sapiens_hsa03015	1.17199771
36	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.16578381
37	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.08247398
38	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.05321344
39	Peroxisome_Homo sapiens_hsa04146	1.04129808
40	Galactose metabolism_Homo sapiens_hsa00052	1.01197758
41	Purine metabolism_Homo sapiens_hsa00230	1.01009316
42	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.99589850
43	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.99581634
44	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.98710509
45	Vibrio cholerae infection_Homo sapiens_hsa05110	0.94195024
46	Selenocompound metabolism_Homo sapiens_hsa00450	0.93880293
47	Shigellosis_Homo sapiens_hsa05131	0.93035704
48	Parkinsons disease_Homo sapiens_hsa05012	0.92937472
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.90241518
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.89598700
51	Sulfur metabolism_Homo sapiens_hsa00920	0.89289677
52	Glutathione metabolism_Homo sapiens_hsa00480	0.88533882
53	Bladder cancer_Homo sapiens_hsa05219	0.87508787
54	Arginine and proline metabolism_Homo sapiens_hsa00330	0.85398206
55	Steroid biosynthesis_Homo sapiens_hsa00100	0.79171391
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.73774195
57	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.71460396
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.70551244
59	One carbon pool by folate_Homo sapiens_hsa00670	0.66868913
60	Legionellosis_Homo sapiens_hsa05134	0.66557156
61	p53 signaling pathway_Homo sapiens_hsa04115	0.66440219
62	Alcoholism_Homo sapiens_hsa05034	0.65078637
63	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.64572777
64	Oxidative phosphorylation_Homo sapiens_hsa00190	0.64077295
65	Lysosome_Homo sapiens_hsa04142	0.63613805
66	Oocyte meiosis_Homo sapiens_hsa04114	0.63534088
67	Viral carcinogenesis_Homo sapiens_hsa05203	0.61196214
68	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.61146769
69	Huntingtons disease_Homo sapiens_hsa05016	0.58185616
70	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.57266676
71	Metabolic pathways_Homo sapiens_hsa01100	0.55437872
72	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53074668
73	Salmonella infection_Homo sapiens_hsa05132	0.52071032
74	Basal transcription factors_Homo sapiens_hsa03022	0.51733198
75	RNA degradation_Homo sapiens_hsa03018	0.51493484
76	Apoptosis_Homo sapiens_hsa04210	0.49454325
77	Propanoate metabolism_Homo sapiens_hsa00640	0.49118779
78	Herpes simplex infection_Homo sapiens_hsa05168	0.46700466
79	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.45851076
80	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.45658951
81	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45011776
82	Viral myocarditis_Homo sapiens_hsa05416	0.44465789
83	Hepatitis B_Homo sapiens_hsa05161	0.44014342
84	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.42655793
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42398985
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.41831498
87	Phagosome_Homo sapiens_hsa04145	0.35689534
88	Arginine biosynthesis_Homo sapiens_hsa00220	0.35153870
89	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.32400696
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.28056124
91	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.27775814
92	Alzheimers disease_Homo sapiens_hsa05010	0.27630466
93	Butanoate metabolism_Homo sapiens_hsa00650	0.27194991
94	Protein export_Homo sapiens_hsa03060	0.25919951
95	Phenylalanine metabolism_Homo sapiens_hsa00360	0.25265019
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.21729580
97	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.19415858
98	Lysine degradation_Homo sapiens_hsa00310	0.18577383
99	Collecting duct acid secretion_Homo sapiens_hsa04966	0.16957602
100	Influenza A_Homo sapiens_hsa05164	0.16854985

SLC25A1P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »