SLC25A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a protein that localizes to the mitochondrial inner membrane and likely functions as a transporter of small molecules such as ornithine. This gene is located between the protocadherin beta and gamma gene clusters on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.47188925
2plasma membrane fusion (GO:0045026)9.47027808
3epithelial cilium movement (GO:0003351)9.12952017
4spermatid development (GO:0007286)8.97380331
5motile cilium assembly (GO:0044458)8.65512141
6reproduction (GO:0000003)8.59411199
7piRNA metabolic process (GO:0034587)8.01747643
8negative regulation of inclusion body assembly (GO:0090084)7.57207071
9regulation of cilium movement (GO:0003352)7.51669266
10cilium movement (GO:0003341)7.46918731
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.14044232
12male meiosis (GO:0007140)7.04677530
13synaptonemal complex organization (GO:0070193)6.87515430
14single fertilization (GO:0007338)6.85509543
15synaptonemal complex assembly (GO:0007130)6.63237072
16sperm capacitation (GO:0048240)6.45324342
17spermatogenesis (GO:0007283)6.21454680
18male gamete generation (GO:0048232)6.18992594
19regulation of inclusion body assembly (GO:0090083)6.02354207
20fertilization (GO:0009566)5.91740963
21ventricular system development (GO:0021591)5.77206327
22gamete generation (GO:0007276)5.66816709
23organic cation transport (GO:0015695)5.58642496
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.19489715
25calcium ion-dependent exocytosis (GO:0017156)5.13388049
26microtubule depolymerization (GO:0007019)5.10978406
27germ cell development (GO:0007281)5.06195380
28DNA methylation involved in gamete generation (GO:0043046)5.00910549
29cell recognition (GO:0008037)4.83756320
30seminiferous tubule development (GO:0072520)4.80286332
31male meiosis I (GO:0007141)4.72972839
32chromosome organization involved in meiosis (GO:0070192)4.64608173
33regulation of microtubule-based movement (GO:0060632)4.63895297
34multicellular organismal reproductive process (GO:0048609)4.45738549
35chromosome condensation (GO:0030261)4.37759646
36microtubule severing (GO:0051013)4.30349795
37meiotic nuclear division (GO:0007126)4.28628239
38DNA packaging (GO:0006323)4.26505341
39protein refolding (GO:0042026)4.22746904
40protein localization to cilium (GO:0061512)4.12609190
41left/right pattern formation (GO:0060972)4.11373103
42sequestering of actin monomers (GO:0042989)3.90887100
43spermatid nucleus differentiation (GO:0007289)3.89613006
44glycerol ether metabolic process (GO:0006662)3.86926608
45meiotic cell cycle (GO:0051321)3.83643943
46chaperone-mediated protein complex assembly (GO:0051131)3.75512658
47meiosis I (GO:0007127)3.72150293
48intraciliary transport (GO:0042073)3.71461529
49genitalia morphogenesis (GO:0035112)3.63568176
50multicellular organismal development (GO:0007275)3.58991344
51ether metabolic process (GO:0018904)3.53701018
52nuclear pore complex assembly (GO:0051292)3.50430444
53regulation of spindle checkpoint (GO:0090231)3.49169530
54mitotic sister chromatid cohesion (GO:0007064)3.47692507
55amino-acid betaine transport (GO:0015838)3.46316269
56carnitine transport (GO:0015879)3.46316269
57interferon-gamma secretion (GO:0072643)3.45724250
58carnitine transmembrane transport (GO:1902603)3.45317716
59protein polyglutamylation (GO:0018095)3.39732478
60monoubiquitinated protein deubiquitination (GO:0035520)3.27667323
61pore complex assembly (GO:0046931)3.14991972
62gene silencing by RNA (GO:0031047)3.14816993
63protein-DNA complex disassembly (GO:0032986)3.09766448
64nucleosome disassembly (GO:0006337)3.09766448
65nucleus organization (GO:0006997)3.08099135
66RNA destabilization (GO:0050779)3.07744632
67cilium organization (GO:0044782)3.06690659
68single strand break repair (GO:0000012)3.06492198
69regulation of protein polyubiquitination (GO:1902914)3.06394943
70synapsis (GO:0007129)3.05923147
71GTP biosynthetic process (GO:0006183)2.97860016
72nucleoside diphosphate phosphorylation (GO:0006165)2.97711482
73cilium assembly (GO:0042384)2.96148747
74microtubule-based movement (GO:0007018)2.91265145
75negative regulation of organelle assembly (GO:1902116)2.87000002
76axoneme assembly (GO:0035082)2.84221894
77cellular component assembly involved in morphogenesis (GO:0010927)2.83552454
78polyol catabolic process (GO:0046174)2.79694260
79centriole assembly (GO:0098534)2.79508844
80meiotic cell cycle process (GO:1903046)2.78924381
81regulation of cilium assembly (GO:1902017)2.78478304
82cilium morphogenesis (GO:0060271)2.75935306
83alditol metabolic process (GO:0019400)2.75519905
84UTP biosynthetic process (GO:0006228)2.75339446
85centriole replication (GO:0007099)2.74585008
86protein K11-linked deubiquitination (GO:0035871)2.67970066
87nuclear pore organization (GO:0006999)2.66691807
88peptidyl-glutamic acid modification (GO:0018200)2.65617984
89gene silencing (GO:0016458)2.61822506
90fusion of sperm to egg plasma membrane (GO:0007342)12.6002036
91sperm motility (GO:0030317)12.4008724
92sperm-egg recognition (GO:0035036)11.2012810
93acrosome assembly (GO:0001675)11.0654890
94acrosome reaction (GO:0007340)11.0344393
95cell wall macromolecule catabolic process (GO:0016998)10.4430999
96cell wall macromolecule metabolic process (GO:0044036)10.4430999
97multicellular organism reproduction (GO:0032504)10.4262735
98cilium or flagellum-dependent cell motility (GO:0001539)10.3450256
99binding of sperm to zona pellucida (GO:0007339)10.2044594
100cell-cell recognition (GO:0009988)10.0648222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.19076001
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.84901218
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.73446417
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.69412393
5CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.60828337
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37404317
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.19531167
8VDR_22108803_ChIP-Seq_LS180_Human2.17979687
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.03764662
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00447753
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.9845644
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.99766783
13ZNF274_21170338_ChIP-Seq_K562_Hela1.97714001
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93562141
15ELK4_26923725_Chip-Seq_MESODERM_Mouse1.90404379
16RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87491519
17STAT1_17558387_ChIP-Seq_HELA_Human1.81321041
18* WDR5_24793694_ChIP-Seq_LNCAP_Human1.80432613
19TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.77171120
20GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.60537885
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60323096
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53479091
23CBP_20019798_ChIP-Seq_JUKART_Human1.53479091
24RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.53438347
25FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52544548
26GATA3_21867929_ChIP-Seq_CD8_Mouse1.52183599
27MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46769142
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.44156820
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36905502
30TAL1_26923725_Chip-Seq_HPCs_Mouse1.34040257
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31963424
32FLI1_21867929_ChIP-Seq_TH2_Mouse1.31851460
33SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29439257
34LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.26804758
35FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26520043
36SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.26271388
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.25998438
38KDM2B_26808549_Chip-Seq_REH_Human1.24995698
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24810933
40REST_21632747_ChIP-Seq_MESCs_Mouse1.23921141
41ERG_20517297_ChIP-Seq_VCAP_Human1.23746629
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22683971
43GF1_26923725_Chip-Seq_HPCs_Mouse1.20824057
44SOX2_22085726_ChIP-Seq_NPCs_Mouse1.19365680
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.18935029
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18856661
47RUNX1_26923725_Chip-Seq_HPCs_Mouse1.17928632
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.15602540
49P53_21459846_ChIP-Seq_SAOS-2_Human1.15472488
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13625392
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12099753
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10225631
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09289529
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.08507498
55RARA_24833708_ChIP-Seq_LIVER_Mouse1.07164849
56SOX9_26525672_Chip-Seq_HEART_Mouse1.06940795
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05920902
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05158387
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.05111604
60KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.03759794
61ESET_19884257_ChIP-Seq_ESCs_Mouse1.03380002
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03289377
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03289377
64CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00623162
65GATA3_21867929_ChIP-Seq_TH1_Mouse1.00262620
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99233922
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98565343
68PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98147006
69CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97666054
70EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97411683
71RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96443275
72SPI1_26923725_Chip-Seq_HPCs_Mouse0.96396121
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95649339
74* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95065507
75NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94272298
76P53_22387025_ChIP-Seq_ESCs_Mouse0.94202147
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94159484
78RNF2_27304074_Chip-Seq_NSC_Mouse0.93863056
79EZH2_27294783_Chip-Seq_NPCs_Mouse0.92580761
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91555569
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91188832
82OCT4_18555785_Chip-Seq_ESCs_Mouse0.90864977
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90801367
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89060837
85RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89041001
86GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88939813
87* YY1_22570637_ChIP-Seq_MALME-3M_Human0.88447144
88CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88263150
89STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87070424
90MYC_27129775_Chip-Seq_CORNEA_Mouse0.85820509
91NFYB_21822215_ChIP-Seq_K562_Human0.85614003
92* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.85568922
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84895983
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84641101
95SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84578423
96BCAT_22108803_ChIP-Seq_LS180_Human0.83564104
97P300_18555785_Chip-Seq_ESCs_Mouse0.83496144
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83396739
99CBX2_27304074_Chip-Seq_ESCs_Mouse0.82889037
100CMYC_18555785_Chip-Seq_ESCs_Mouse0.82829770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.55272015
2MP0001929_abnormal_gametogenesis5.08962963
3MP0008877_abnormal_DNA_methylation4.37282331
4MP0002210_abnormal_sex_determination3.23345865
5MP0002161_abnormal_fertility/fecundity2.95741189
6MP0001145_abnormal_male_reproductive2.77574485
7MP0000653_abnormal_sex_gland2.36115219
8MP0004233_abnormal_muscle_weight2.21169141
9MP0002160_abnormal_reproductive_system2.15634338
10MP0005410_abnormal_fertilization15.0798085
11MP0002139_abnormal_hepatobiliary_system1.91778286
12MP0005670_abnormal_white_adipose1.72196242
13MP0002653_abnormal_ependyma_morphology1.71450881
14MP0003646_muscle_fatigue1.62850631
15MP0005623_abnormal_meninges_morphology1.55115457
16MP0005076_abnormal_cell_differentiation1.41477184
17MP0008058_abnormal_DNA_repair1.32049116
18MP0008057_abnormal_DNA_replication1.30468941
19MP0003115_abnormal_respiratory_system1.29059083
20MP0005389_reproductive_system_phenotype1.27516185
21MP0005647_abnormal_sex_gland1.21072807
22MP0010094_abnormal_chromosome_stability1.20407789
23MP0004510_myositis1.10165417
24MP0008007_abnormal_cellular_replicative1.09545279
25MP0002282_abnormal_trachea_morphology1.01337429
26MP0001765_abnormal_ion_homeostasis0.96399629
27MP0009046_muscle_twitch0.95678078
28MP0005423_abnormal_somatic_nervous0.91328556
29MP0002234_abnormal_pharynx_morphology0.90731293
30MP0002877_abnormal_melanocyte_morpholog0.89472715
31MP0001986_abnormal_taste_sensitivity0.83633594
32MP0000015_abnormal_ear_pigmentation0.82886721
33MP0003329_amyloid_beta_deposits0.77750992
34MP0005310_abnormal_salivary_gland0.75497085
35MP0003787_abnormal_imprinting0.74963502
36MP0001873_stomach_inflammation0.74890823
37MP0003183_abnormal_peptide_metabolism0.74429582
38MP0003111_abnormal_nucleus_morphology0.73204372
39MP0002254_reproductive_system_inflammat0.72992495
40MP0003077_abnormal_cell_cycle0.66209576
41MP0002138_abnormal_hepatobiliary_system0.65978045
42MP0000678_abnormal_parathyroid_gland0.60088199
43MP0003786_premature_aging0.59408744
44MP0000604_amyloidosis0.58440187
45MP0000358_abnormal_cell_content/0.56994582
46MP0010307_abnormal_tumor_latency0.55792024
47MP0000569_abnormal_digit_pigmentation0.55079209
48MP0005365_abnormal_bile_salt0.53851670
49MP0005253_abnormal_eye_physiology0.52460573
50MP0008995_early_reproductive_senescence0.52196841
51MP0002876_abnormal_thyroid_physiology0.51298913
52MP0006072_abnormal_retinal_apoptosis0.50662939
53MP0004264_abnormal_extraembryonic_tissu0.50576021
54MP0005397_hematopoietic_system_phenotyp0.50382969
55MP0001545_abnormal_hematopoietic_system0.50382969
56MP0005391_vision/eye_phenotype0.49920777
57MP0001293_anophthalmia0.49348423
58MP0008569_lethality_at_weaning0.49037061
59MP0009278_abnormal_bone_marrow0.46640977
60MP0001984_abnormal_olfaction0.45288729
61MP0002697_abnormal_eye_size0.45249758
62MP0005636_abnormal_mineral_homeostasis0.44677731
63MP0002693_abnormal_pancreas_physiology0.44200783
64MP0009053_abnormal_anal_canal0.43828876
65MP0001529_abnormal_vocalization0.43796717
66MP0001730_embryonic_growth_arrest0.43738717
67MP0000313_abnormal_cell_death0.43370303
68MP0002084_abnormal_developmental_patter0.42298013
69MP0004043_abnormal_pH_regulation0.42236068
70MP0002332_abnormal_exercise_endurance0.41890753
71MP0001672_abnormal_embryogenesis/_devel0.41282623
72MP0005380_embryogenesis_phenotype0.41282623
73MP0003890_abnormal_embryonic-extraembry0.41070235
74MP0003943_abnormal_hepatobiliary_system0.41042352
75MP0004270_analgesia0.40732353
76MP0004808_abnormal_hematopoietic_stem0.38875191
77MP0003693_abnormal_embryo_hatching0.37772763
78MP0009672_abnormal_birth_weight0.37766621
79MP0003861_abnormal_nervous_system0.37678871
80MP0002928_abnormal_bile_duct0.37622131
81MP0001324_abnormal_eye_pigmentation0.37521005
82MP0003942_abnormal_urinary_system0.37011882
83MP0001919_abnormal_reproductive_system0.36922609
84MP0002177_abnormal_outer_ear0.36602121
85MP0004197_abnormal_fetal_growth/weight/0.35999161
86MP0002272_abnormal_nervous_system0.35276528
87MP0003948_abnormal_gas_homeostasis0.35141522
88MP0004957_abnormal_blastocyst_morpholog0.34202340
89MP0008932_abnormal_embryonic_tissue0.33910650
90MP0005408_hypopigmentation0.33666279
91MP0006036_abnormal_mitochondrial_physio0.32604129
92MP0002152_abnormal_brain_morphology0.31947843
93MP0001697_abnormal_embryo_size0.31935973
94MP0002169_no_abnormal_phenotype0.31341180
95MP0002088_abnormal_embryonic_growth/wei0.31316612
96MP0003984_embryonic_growth_retardation0.31227524
97MP0002873_normal_phenotype0.31193818
98MP0002405_respiratory_system_inflammati0.31153091
99MP0009703_decreased_birth_body0.30745153
100MP0001764_abnormal_homeostasis0.30243817

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.31633927
2Chronic bronchitis (HP:0004469)8.13541088
3Abnormal respiratory motile cilium morphology (HP:0005938)8.06493423
4Abnormal respiratory epithelium morphology (HP:0012253)8.06493423
5Rhinitis (HP:0012384)7.14339463
6Infertility (HP:0000789)6.59230339
7Nasal polyposis (HP:0100582)6.19036320
8Abnormal ciliary motility (HP:0012262)6.15635410
9Nephronophthisis (HP:0000090)5.01501946
10Abnormality of the nasal mucosa (HP:0000433)4.93795370
11Bronchitis (HP:0012387)4.67561208
12Bronchiectasis (HP:0002110)4.40790342
13Abnormality of the renal medulla (HP:0100957)3.79868543
14Male infertility (HP:0003251)3.72352075
15Abnormal spermatogenesis (HP:0008669)3.62061617
16Medial flaring of the eyebrow (HP:0010747)3.47511773
17Recurrent otitis media (HP:0000403)3.14531684
18Impulsivity (HP:0100710)2.84553395
19Gonadotropin excess (HP:0000837)2.83755064
20Molar tooth sign on MRI (HP:0002419)2.80674483
21Abnormality of midbrain morphology (HP:0002418)2.80674483
22Tubular atrophy (HP:0000092)2.78536984
23Recurrent sinusitis (HP:0011108)2.65773343
24Abnormality of the lower motor neuron (HP:0002366)2.64151201
25Gait imbalance (HP:0002141)2.52924110
26Tubulointerstitial nephritis (HP:0001970)2.46854212
27Congenital primary aphakia (HP:0007707)2.44187903
28Azoospermia (HP:0000027)2.42606555
29Postaxial foot polydactyly (HP:0001830)2.36918487
30Recurrent bronchitis (HP:0002837)2.36907955
31Amyotrophic lateral sclerosis (HP:0007354)2.31086365
32Heterotopia (HP:0002282)2.25501543
33Nephrogenic diabetes insipidus (HP:0009806)2.21836432
34Fibular hypoplasia (HP:0003038)2.15632705
35Tubulointerstitial abnormality (HP:0001969)2.10520583
36Aplasia/Hypoplasia of the lens (HP:0008063)2.09789510
37Stage 5 chronic kidney disease (HP:0003774)2.08327111
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.2087062
39Absent/shortened dynein arms (HP:0200106)11.8415991
40Dynein arm defect of respiratory motile cilia (HP:0012255)11.8415991
41Abnormality of the renal cortex (HP:0011035)1.97476966
42Poor coordination (HP:0002370)1.94793521
43Renal dysplasia (HP:0000110)1.94721866
44Microglossia (HP:0000171)1.93151205
45Double outlet right ventricle (HP:0001719)1.92601709
46Congenital malformation of the right heart (HP:0011723)1.92601709
47Postaxial hand polydactyly (HP:0001162)1.92550792
48Abnormal gallbladder physiology (HP:0012438)1.92053080
49Cholecystitis (HP:0001082)1.92053080
50Abnormal drinking behavior (HP:0030082)1.91197197
51Polydipsia (HP:0001959)1.91197197
52Congenital hepatic fibrosis (HP:0002612)1.85000885
53Easy fatigability (HP:0003388)1.79958652
54Facial cleft (HP:0002006)1.79057821
55Impaired proprioception (HP:0010831)1.77934842
56Ectopic kidney (HP:0000086)1.68985976
57Vaginal atresia (HP:0000148)1.68827792
58Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68560224
59Tubulointerstitial fibrosis (HP:0005576)1.68363285
6011 pairs of ribs (HP:0000878)1.67976211
61Oculomotor apraxia (HP:0000657)1.67683008
62Median cleft lip (HP:0000161)1.65230244
63Dyschromatopsia (HP:0007641)1.63966847
64Short ribs (HP:0000773)1.63565241
65Exercise-induced myalgia (HP:0003738)1.63296544
66Aplasia/Hypoplasia of the tongue (HP:0010295)1.63285594
67Selective tooth agenesis (HP:0001592)1.61294513
68Genital tract atresia (HP:0001827)1.61077413
69Bell-shaped thorax (HP:0001591)1.53658257
70Decreased central vision (HP:0007663)1.51086471
71Spastic tetraparesis (HP:0001285)1.50569504
72Abnormality of renal excretion (HP:0011036)1.50308431
73Absent frontal sinuses (HP:0002688)1.48911033
74True hermaphroditism (HP:0010459)1.48778055
75Short thorax (HP:0010306)1.48446599
76Cystic liver disease (HP:0006706)1.47621664
77Myoglobinuria (HP:0002913)1.46791723
78Hemiparesis (HP:0001269)1.45172874
79Breast carcinoma (HP:0003002)1.43899348
80Pancreatic fibrosis (HP:0100732)1.42345094
81Bifid tongue (HP:0010297)1.40278726
82Choroideremia (HP:0001139)1.38730507
83Abnormality of the neuromuscular junction (HP:0003398)1.36495781
84Fatigable weakness (HP:0003473)1.36495781
85Bile duct proliferation (HP:0001408)1.36313554
86Abnormal biliary tract physiology (HP:0012439)1.36313554
87Attenuation of retinal blood vessels (HP:0007843)1.34691594
88Bony spicule pigmentary retinopathy (HP:0007737)1.32934868
89Upper motor neuron abnormality (HP:0002127)1.31548384
90Sloping forehead (HP:0000340)1.31290096
91Sclerocornea (HP:0000647)1.29141596
92Nephropathy (HP:0000112)1.28951213
93Abnormality of ocular smooth pursuit (HP:0000617)1.28363291
94Anencephaly (HP:0002323)1.27879972
95Aplasia/Hypoplasia of the fibula (HP:0006492)1.27465431
96Vascular calcification (HP:0004934)1.23602247
97Short femoral neck (HP:0100864)1.21807843
98Preaxial hand polydactyly (HP:0001177)1.20548774
99Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.20236287
100Absent epiphyses (HP:0010577)1.20236287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.73137543
2PDK36.73137543
3TESK15.97962806
4PRKD35.63551145
5ICK5.55146977
6PDK25.37437598
7MUSK3.10705643
8PNCK2.39213441
9FRK1.99686843
10PTK2B1.68729743
11MAPK151.66436950
12NEK21.64427228
13WNK41.59451595
14STK381.47204249
15STK391.25225021
16PASK1.22587491
17PDK10.99598856
18DYRK1B0.97793768
19DYRK30.88327795
20CAMK1G0.87697008
21TTK0.85029173
22IRAK10.83604163
23MAPKAPK50.77263480
24PINK10.67536875
25CCNB10.66962884
26PRPF4B0.63463322
27CHEK20.63226444
28CDC70.59940576
29WNK10.59852474
30PIM10.56453574
31RPS6KB10.56044474
32ERBB40.54981985
33TSSK60.54213503
34TESK20.53496746
35NEK60.52870143
36ATR0.52857042
37ATM0.52493672
38PDPK10.47082316
39PLK30.46991040
40MAP3K140.46391365
41CHEK10.44890690
42MTOR0.38633799
43BRAF0.38518441
44IRAK20.38429786
45PRKCZ0.37034159
46MAP3K100.35454298
47CHUK0.34931673
48BMPR1B0.32904398
49IKBKB0.32707281
50PIM20.31941200
51RPS6KA60.31740584
52RPS6KA20.31730421
53RPS6KL10.31268839
54RPS6KC10.31268839
55RPS6KA10.31215926
56MST40.31117790
57PKN10.29180876
58TYRO30.26999940
59PLK40.26796926
60MAP2K70.26748728
61CDK120.26614245
62STK30.26263306
63BCKDK0.25036495
64PRKCG0.24616877
65PLK10.24093771
66EIF2AK20.23669950
67PAK10.23231387
68SRPK10.23133090
69ARAF0.22892257
70MAP3K40.22606136
71IKBKE0.22448373
72MARK10.21104513
73BRSK10.20734593
74PRKAA10.20170444
75AURKA0.18691938
76MARK30.18689295
77MAPK110.16668762
78NTRK20.16575845
79SGK20.14741349
80YES10.13818092
81BRSK20.12730214
82CSNK2A20.12219797
83BUB10.11949979
84BCR0.11685675
85EEF2K0.11273813
86PRKDC0.11163194
87GSK3B0.11040619
88WEE10.10934150
89RPS6KA50.09719718
90MAPK70.09395698
91CSNK1D0.09305041
92CSNK2A10.09222528
93CDK20.08174394
94CDK10.07807287
95PTK60.06465475
96MAPK80.06310666
97STK38L0.06173180
98AKT30.05550709
99PAK20.05446402
100TBK10.05248264

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.06861021
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.95715778
3Pyruvate metabolism_Homo sapiens_hsa006203.82140119
4Fatty acid biosynthesis_Homo sapiens_hsa000612.91114870
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.84040262
6Glucagon signaling pathway_Homo sapiens_hsa049222.80781725
7Propanoate metabolism_Homo sapiens_hsa006402.62138067
8Amphetamine addiction_Homo sapiens_hsa050312.43625949
9Fanconi anemia pathway_Homo sapiens_hsa034602.36263197
10Selenocompound metabolism_Homo sapiens_hsa004502.35255117
11Basal transcription factors_Homo sapiens_hsa030222.13362607
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.10218115
13Linoleic acid metabolism_Homo sapiens_hsa005912.06994957
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.98350926
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90645665
16Antigen processing and presentation_Homo sapiens_hsa046121.79464954
17Oocyte meiosis_Homo sapiens_hsa041141.71341430
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.70293463
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.59077166
20PPAR signaling pathway_Homo sapiens_hsa033201.56866662
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.56602058
22RNA transport_Homo sapiens_hsa030131.52620818
23mRNA surveillance pathway_Homo sapiens_hsa030151.51689405
24Phenylalanine metabolism_Homo sapiens_hsa003601.50591973
25Glycerolipid metabolism_Homo sapiens_hsa005611.43959714
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37776447
27Legionellosis_Homo sapiens_hsa051341.37177109
28Taste transduction_Homo sapiens_hsa047421.31404333
29Huntingtons disease_Homo sapiens_hsa050161.27307051
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25506333
31Non-homologous end-joining_Homo sapiens_hsa034501.24580908
32Systemic lupus erythematosus_Homo sapiens_hsa053221.24468805
33Dorso-ventral axis formation_Homo sapiens_hsa043201.23134768
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21164193
35Purine metabolism_Homo sapiens_hsa002301.20717288
36Fatty acid degradation_Homo sapiens_hsa000711.20716817
37Long-term potentiation_Homo sapiens_hsa047201.17575197
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.07723817
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05744791
40Carbon metabolism_Homo sapiens_hsa012001.05663600
41Pentose phosphate pathway_Homo sapiens_hsa000301.00542626
42Fatty acid metabolism_Homo sapiens_hsa012120.99632265
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.97659157
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95518614
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.95313945
46Renin secretion_Homo sapiens_hsa049240.92812988
47ABC transporters_Homo sapiens_hsa020100.88645072
48Fructose and mannose metabolism_Homo sapiens_hsa000510.87848372
49Fat digestion and absorption_Homo sapiens_hsa049750.87759519
50Alcoholism_Homo sapiens_hsa050340.85952668
51Cardiac muscle contraction_Homo sapiens_hsa042600.84587890
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84022480
53Pyrimidine metabolism_Homo sapiens_hsa002400.81747307
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81515938
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77964995
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72389928
57N-Glycan biosynthesis_Homo sapiens_hsa005100.71598951
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71338375
59Viral carcinogenesis_Homo sapiens_hsa052030.70883538
60Protein export_Homo sapiens_hsa030600.68907992
61Thyroid hormone synthesis_Homo sapiens_hsa049180.67573551
62RNA degradation_Homo sapiens_hsa030180.67553230
63Glutathione metabolism_Homo sapiens_hsa004800.65879126
64Cocaine addiction_Homo sapiens_hsa050300.65367986
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.64582647
66Sulfur metabolism_Homo sapiens_hsa009200.64428136
67Estrogen signaling pathway_Homo sapiens_hsa049150.64288263
68Insulin secretion_Homo sapiens_hsa049110.62580439
69Ether lipid metabolism_Homo sapiens_hsa005650.58390531
70Hedgehog signaling pathway_Homo sapiens_hsa043400.56155295
71Tyrosine metabolism_Homo sapiens_hsa003500.55683246
72Epstein-Barr virus infection_Homo sapiens_hsa051690.52093050
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50612877
74Cell cycle_Homo sapiens_hsa041100.49022982
75Vibrio cholerae infection_Homo sapiens_hsa051100.48510884
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.47611708
77Insulin resistance_Homo sapiens_hsa049310.45938303
78Biosynthesis of amino acids_Homo sapiens_hsa012300.43006167
79B cell receptor signaling pathway_Homo sapiens_hsa046620.42087352
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39894599
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39714207
82Type II diabetes mellitus_Homo sapiens_hsa049300.39466874
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37883615
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35156592
85Influenza A_Homo sapiens_hsa051640.34513335
86Homologous recombination_Homo sapiens_hsa034400.34176550
87Calcium signaling pathway_Homo sapiens_hsa040200.33569268
88Metabolic pathways_Homo sapiens_hsa011000.33328270
89Arachidonic acid metabolism_Homo sapiens_hsa005900.33019365
90Circadian entrainment_Homo sapiens_hsa047130.32038267
91Synaptic vesicle cycle_Homo sapiens_hsa047210.30878235
92AMPK signaling pathway_Homo sapiens_hsa041520.29780069
93Collecting duct acid secretion_Homo sapiens_hsa049660.29771656
94Basal cell carcinoma_Homo sapiens_hsa052170.29688953
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28236125
96Measles_Homo sapiens_hsa051620.27548841
97HTLV-I infection_Homo sapiens_hsa051660.26657604
98Endocytosis_Homo sapiens_hsa041440.25210231
99Dopaminergic synapse_Homo sapiens_hsa047280.23957489
100Toxoplasmosis_Homo sapiens_hsa051450.23924466

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