SLC25A20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.82504771
2L-phenylalanine catabolic process (GO:0006559)5.82504771
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.61817217
4L-phenylalanine metabolic process (GO:0006558)5.61817217
5aromatic amino acid family catabolic process (GO:0009074)5.31743483
6serine family amino acid catabolic process (GO:0009071)5.22783018
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.18079907
8amino-acid betaine metabolic process (GO:0006577)5.15793374
9kynurenine metabolic process (GO:0070189)4.95180315
10glyoxylate metabolic process (GO:0046487)4.93163498
11fatty acid beta-oxidation (GO:0006635)4.91121458
12regulation of triglyceride catabolic process (GO:0010896)4.89505494
13tryptophan catabolic process (GO:0006569)4.88419342
14indole-containing compound catabolic process (GO:0042436)4.88419342
15indolalkylamine catabolic process (GO:0046218)4.88419342
16regulation of sequestering of triglyceride (GO:0010889)4.85826713
17alpha-linolenic acid metabolic process (GO:0036109)4.83832933
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.81351845
19urea metabolic process (GO:0019627)4.71630722
20urea cycle (GO:0000050)4.71630722
21lysine catabolic process (GO:0006554)4.69139365
22lysine metabolic process (GO:0006553)4.69139365
23sulfur amino acid catabolic process (GO:0000098)4.68294261
24bile acid biosynthetic process (GO:0006699)4.65272944
25tryptophan metabolic process (GO:0006568)4.60430818
26cysteine metabolic process (GO:0006534)4.58858735
27fatty acid oxidation (GO:0019395)4.57309366
28biotin metabolic process (GO:0006768)4.53254730
29* fatty acid transmembrane transport (GO:1902001)4.49583487
30lipid oxidation (GO:0034440)4.48807997
31fatty acid catabolic process (GO:0009062)4.47589017
32cellular ketone body metabolic process (GO:0046950)4.47226501
33nitrogen cycle metabolic process (GO:0071941)4.45834496
34carnitine metabolic process (GO:0009437)4.44305166
35acetyl-CoA metabolic process (GO:0006084)4.43748416
36glycine metabolic process (GO:0006544)4.36815126
37negative regulation of fatty acid biosynthetic process (GO:0045717)4.36040910
38homocysteine metabolic process (GO:0050667)4.35152641
39* carnitine shuttle (GO:0006853)4.32266963
40acylglycerol homeostasis (GO:0055090)4.23735344
41triglyceride homeostasis (GO:0070328)4.23735344
42bile acid metabolic process (GO:0008206)4.20023953
43monocarboxylic acid catabolic process (GO:0072329)4.17644772
44branched-chain amino acid catabolic process (GO:0009083)4.15912445
45alpha-amino acid catabolic process (GO:1901606)4.11850524
46high-density lipoprotein particle remodeling (GO:0034375)4.09557569
47regulation of fibrinolysis (GO:0051917)4.07844821
48short-chain fatty acid metabolic process (GO:0046459)4.06721339
49negative regulation of fibrinolysis (GO:0051918)4.06316328
50aromatic amino acid family metabolic process (GO:0009072)4.02816263
51epoxygenase P450 pathway (GO:0019373)4.00348388
52serine family amino acid metabolic process (GO:0009069)3.99282753
53ethanol oxidation (GO:0006069)3.94011019
54positive regulation of fatty acid beta-oxidation (GO:0032000)3.92406187
55organic acid catabolic process (GO:0016054)3.89844198
56carboxylic acid catabolic process (GO:0046395)3.89844198
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.89717261
58regulation of protein activation cascade (GO:2000257)3.89268759
59cellular amino acid catabolic process (GO:0009063)3.88546957
602-oxoglutarate metabolic process (GO:0006103)3.87612012
61antigen processing and presentation of endogenous antigen (GO:0019883)3.86116269
62peptidyl-glutamic acid carboxylation (GO:0017187)3.84720184
63protein carboxylation (GO:0018214)3.84720184
64bile acid and bile salt transport (GO:0015721)3.84217743
65ketone body metabolic process (GO:1902224)3.83718789
66regulation of bile acid biosynthetic process (GO:0070857)3.83403674
67NADH metabolic process (GO:0006734)3.82642599
68plasma lipoprotein particle clearance (GO:0034381)3.81886455
69coenzyme catabolic process (GO:0009109)3.80835034
70complement activation, alternative pathway (GO:0006957)3.80129119
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.78056883
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.76744214
73tyrosine metabolic process (GO:0006570)3.76007441
74regulation of cholesterol esterification (GO:0010872)3.72468862
75regulation of cholesterol metabolic process (GO:0090181)3.65955593
76aspartate family amino acid catabolic process (GO:0009068)3.64573398
77regulation of complement activation (GO:0030449)3.62181136
78branched-chain amino acid metabolic process (GO:0009081)3.62077527
79negative regulation of lipase activity (GO:0060192)3.61010194
80plasma lipoprotein particle remodeling (GO:0034369)3.59191759
81protein-lipid complex remodeling (GO:0034368)3.59191759
82macromolecular complex remodeling (GO:0034367)3.59191759
83positive regulation of lipid catabolic process (GO:0050996)3.58685228
84positive regulation of fatty acid oxidation (GO:0046321)3.57319258
85reverse cholesterol transport (GO:0043691)3.55208397
86serine family amino acid biosynthetic process (GO:0009070)3.51670291
87phospholipid efflux (GO:0033700)3.48162093
88amine catabolic process (GO:0009310)3.45463205
89cellular biogenic amine catabolic process (GO:0042402)3.45463205
90phospholipid homeostasis (GO:0055091)3.45014957
91positive regulation of triglyceride lipase activity (GO:0061365)3.44621455
92positive regulation of lipoprotein lipase activity (GO:0051006)3.44621455
93negative regulation of fatty acid metabolic process (GO:0045922)3.44378358
94indolalkylamine metabolic process (GO:0006586)3.40485406
95regulation of fatty acid oxidation (GO:0046320)3.39884735
96tricarboxylic acid cycle (GO:0006099)3.38108474
97urate metabolic process (GO:0046415)3.37975902
98cholesterol homeostasis (GO:0042632)3.37524017
99negative regulation of cholesterol transport (GO:0032375)3.36373385
100negative regulation of sterol transport (GO:0032372)3.36373385
101cellular glucuronidation (GO:0052695)3.36099606
102arginine metabolic process (GO:0006525)3.35667214
103exogenous drug catabolic process (GO:0042738)3.31195176
104drug catabolic process (GO:0042737)3.31193621
105sterol homeostasis (GO:0055092)3.31035655
106small molecule catabolic process (GO:0044282)3.29502651
107valine metabolic process (GO:0006573)3.28271015
108fat-soluble vitamin biosynthetic process (GO:0042362)3.23214095
109very-low-density lipoprotein particle assembly (GO:0034379)3.20274952
110plasma lipoprotein particle assembly (GO:0034377)3.09903664
111cholesterol efflux (GO:0033344)3.00900511
112detection of other organism (GO:0098543)2.97733252
113drug metabolic process (GO:0017144)2.92719849
114neutrophil activation involved in immune response (GO:0002283)2.90579699
115uronic acid metabolic process (GO:0006063)2.89683683
116glucuronate metabolic process (GO:0019585)2.89683683
117omega-hydroxylase P450 pathway (GO:0097267)2.89128859
118detection of bacterium (GO:0016045)2.88699496
119negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87520218
120negative regulation of cell killing (GO:0031342)2.87520218
121protein-lipid complex assembly (GO:0065005)2.87060201
122positive regulation of gamma-delta T cell activation (GO:0046645)2.81241940
123immunoglobulin mediated immune response (GO:0016064)2.75329437
124triglyceride catabolic process (GO:0019433)2.71330138
125oxaloacetate metabolic process (GO:0006107)2.68930660
126plasma lipoprotein particle organization (GO:0071827)2.67830366
127diacylglycerol metabolic process (GO:0046339)2.65252750
128angiotensin maturation (GO:0002003)2.64503378
129detection of external biotic stimulus (GO:0098581)2.63781677
130acute-phase response (GO:0006953)2.63138722
131acylglycerol catabolic process (GO:0046464)2.59289606
132neutral lipid catabolic process (GO:0046461)2.59289606
133low-density lipoprotein particle remodeling (GO:0034374)2.57947250
134lipoprotein transport (GO:0042953)2.57924753
135protein-lipid complex subunit organization (GO:0071825)2.57920192
136hormone catabolic process (GO:0042447)2.57706653
137regulation of B cell receptor signaling pathway (GO:0050855)2.57006305
138xenobiotic catabolic process (GO:0042178)2.55064165
139ethanol metabolic process (GO:0006067)2.54359318
140Arp2/3 complex-mediated actin nucleation (GO:0034314)2.51842400
141cytolysis (GO:0019835)2.45775125
142cytidine metabolic process (GO:0046087)2.43835436
143cytidine catabolic process (GO:0006216)2.43835436
144cytidine deamination (GO:0009972)2.43835436
145blood coagulation, intrinsic pathway (GO:0007597)2.41948764
146protein activation cascade (GO:0072376)2.39752773
147glycosphingolipid catabolic process (GO:0046479)2.36781203
148complement activation (GO:0006956)2.36103534
149fructose metabolic process (GO:0006000)2.36087099
150positive regulation of fatty acid biosynthetic process (GO:0045723)2.34775552
151antigen processing and presentation via MHC class Ib (GO:0002475)2.33469971
152very long-chain fatty acid metabolic process (GO:0000038)2.31696658

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.59009895
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.79992145
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.60347478
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.96807160
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.92599328
6IRF8_22096565_ChIP-ChIP_GC-B_Human5.31279028
7LXR_22158963_ChIP-Seq_LIVER_Mouse5.30453608
8BP1_19119308_ChIP-ChIP_Hs578T_Human5.12663710
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.57938306
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.31145341
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.23846924
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.34143194
13IRF8_21731497_ChIP-ChIP_J774_Mouse3.30232206
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.22743783
15* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.14689885
16KAP1_22055183_ChIP-Seq_ESCs_Mouse2.64175322
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52596760
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46434382
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34362573
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.28358217
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21290117
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21271234
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19891311
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13502320
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06154097
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98922955
27ZNF263_19887448_ChIP-Seq_K562_Human1.98093436
28SPI1_23547873_ChIP-Seq_NB4_Human1.92383908
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.91986650
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85673427
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.83950428
32* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.76466370
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76458582
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73976769
35MYB_26560356_Chip-Seq_TH2_Human1.73773326
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66190995
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63267713
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61317580
39RUNX_20019798_ChIP-Seq_JUKART_Human1.61218249
40SPI1_23127762_ChIP-Seq_K562_Human1.57568722
41VDR_24763502_ChIP-Seq_THP-1_Human1.54357256
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53014219
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49888152
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49000071
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46847630
46MYB_26560356_Chip-Seq_TH1_Human1.42885246
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40657005
48* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36761752
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36507688
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.36141187
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35826692
52MAF_26560356_Chip-Seq_TH1_Human1.34082898
53* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33808897
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33306660
55HTT_18923047_ChIP-ChIP_STHdh_Human1.32824235
56GATA3_27048872_Chip-Seq_THYMUS_Human1.32251829
57TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.30506566
58* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29798741
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28855490
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28131232
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28017195
62CLOCK_20551151_ChIP-Seq_293T_Human1.27576658
63UTX_26944678_Chip-Seq_JUKART_Human1.27147178
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24108240
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21313977
66* HNF4A_19822575_ChIP-Seq_HepG2_Human1.20981013
67SCL_19346495_ChIP-Seq_HPC-7_Human1.20850118
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19628938
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.19333018
70AR_21909140_ChIP-Seq_LNCAP_Human1.19284501
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18151942
72VDR_21846776_ChIP-Seq_THP-1_Human1.17639969
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16630077
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16018000
75GATA3_26560356_Chip-Seq_TH2_Human1.12365817
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12082974
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11773096
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08109678
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07854893
80* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07564970
81VDR_24787735_ChIP-Seq_THP-1_Human1.07277302
82BCL6_27268052_Chip-Seq_Bcells_Human1.07193382
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06085843
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.05791712
85RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04339499
86GATA1_19941826_ChIP-Seq_K562_Human1.01805476
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01308808
88* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99538731
89CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99427804
90* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98779084
91GATA4_25053715_ChIP-Seq_YYC3_Human0.98622989
92GATA2_21666600_ChIP-Seq_HMVEC_Human0.95554040
93GATA1_22025678_ChIP-Seq_K562_Human0.94954673
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94120014
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92641544
96* BCOR_27268052_Chip-Seq_Bcells_Human0.92506100
97PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91997876
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91797277
99* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91509228
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90264000
101MAF_26560356_Chip-Seq_TH2_Human0.90033027
102KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.89631511
103ELF1_20517297_ChIP-Seq_JURKAT_Human0.89368871
104GATA2_19941826_ChIP-Seq_K562_Human0.87159963
105SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86818229
106PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85198737
107PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83394518
108SPI1_20517297_ChIP-Seq_HL60_Human0.83060597
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82626871
110TFEB_21752829_ChIP-Seq_HELA_Human0.82282314
111PU_27001747_Chip-Seq_BMDM_Mouse0.82187477
112* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81700500
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81045425
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80969491
115* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80968049
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80280660
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.80156533
118* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.79692848
119IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78855052
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.78468083
121LXR_22292898_ChIP-Seq_THP-1_Human0.78444292
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77660465
123GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77396019
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76900986
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.76065102
126STAT1_20625510_ChIP-Seq_HELA_Human0.74000910
127ESET_19884257_ChIP-Seq_ESCs_Mouse0.73703304
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71184931
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70884796
130SALL1_21062744_ChIP-ChIP_HESCs_Human0.70862683
131HNFA_21074721_ChIP-Seq_CACO-2_Human0.70138047
132* SRF_21415370_ChIP-Seq_HL-1_Mouse0.69607335
133GATA6_21074721_ChIP-Seq_CACO-2_Human0.69526607
134STAT1_17558387_ChIP-Seq_HELA_Human0.68838474
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.68596187
136* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.67749748
137RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67730155
138PCGF2_27294783_Chip-Seq_ESCs_Mouse0.67715598
139FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.66997379
140ESR2_21235772_ChIP-Seq_MCF-7_Human0.66139648
141* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.65812876
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.65269076
143CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.64505167
144ESR1_20079471_ChIP-ChIP_T-47D_Human0.64460329
145CDX2_22108803_ChIP-Seq_LS180_Human0.64051299
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.63564702
147SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.63211535
148KAP1_27257070_Chip-Seq_ESCs_Mouse0.62638868
149* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.62529063
150PHF8_20622853_ChIP-Seq_HELA_Human0.61663307
151JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.61354453
152* RARA_24833708_ChIP-Seq_LIVER_Mouse0.61318883
153KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.59288825
154KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.59288825
155KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.59288825
156FOXO3_23340844_ChIP-Seq_DLD1_Human0.58923557
157* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.58630491
158CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.58547869
159* CEBPB_22108803_ChIP-Seq_LS180_Human0.58541415
160TBX20_22328084_ChIP-Seq_HEART_Mouse0.57989539
161TBX20_22080862_ChIP-Seq_HEART_Mouse0.57989539
162TP63_17297297_ChIP-ChIP_HaCaT_Human0.57787203
163SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.57508102
164FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.57495336
165PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.57310118
166PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.57287992
167SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.56919472
168CBP_21632823_ChIP-Seq_H3396_Human0.56822753
169* RARB_24833708_ChIP-Seq_LIVER_Mouse0.56750568
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.56273606
171Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.55851328
172SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.55314254
173CRX_20693478_ChIP-Seq_RETINA_Mouse0.55192391
174NFYA_21822215_ChIP-Seq_K562_Human0.54349861

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.53412321
2MP0005360_urolithiasis5.69181048
3MP0005085_abnormal_gallbladder_physiolo5.53010393
4MP0005365_abnormal_bile_salt5.36692224
5MP0008875_abnormal_xenobiotic_pharmacok4.17554879
6MP0003806_abnormal_nucleotide_metabolis4.07603526
7MP0005451_abnormal_body_composition3.47983419
8MP0009840_abnormal_foam_cell3.15865981
9MP0003252_abnormal_bile_duct3.01103470
10MP0010329_abnormal_lipoprotein_level3.00763623
11MP0005670_abnormal_white_adipose2.91603940
12MP0001835_abnormal_antigen_presentation2.73699602
13MP0005332_abnormal_amino_acid2.64607070
14MP0002837_dystrophic_cardiac_calcinosis2.41237225
15MP0009785_altered_susceptibility_to2.27229093
16MP0003646_muscle_fatigue2.22102693
17MP0002118_abnormal_lipid_homeostasis2.11483932
18MP0003195_calcinosis2.11288127
19MP0005666_abnormal_adipose_tissue2.11253319
20MP0003436_decreased_susceptibility_to2.08425703
21MP0005671_abnormal_response_to2.05509942
22MP0000609_abnormal_liver_physiology2.05064301
23MP0001666_abnormal_nutrient_absorption2.04926699
24MP0004019_abnormal_vitamin_homeostasis2.04657985
25MP0006082_CNS_inflammation2.00703306
26MP0005058_abnormal_lysosome_morphology1.97407388
27MP0005025_abnormal_response_to1.95315484
28MP0005464_abnormal_platelet_physiology1.93041022
29MP0002419_abnormal_innate_immunity1.91743991
30MP0004185_abnormal_adipocyte_glucose1.85448822
31MP0004130_abnormal_muscle_cell1.82609915
32MP0000685_abnormal_immune_system1.80275113
33MP0005083_abnormal_biliary_tract1.80186151
34MP0003191_abnormal_cellular_cholesterol1.77153031
35MP0001800_abnormal_humoral_immune1.77100166
36MP0005000_abnormal_immune_tolerance1.74284677
37MP0001790_abnormal_immune_system1.73137182
38MP0005387_immune_system_phenotype1.73137182
39MP0005319_abnormal_enzyme/_coenzyme1.68329520
40MP0006036_abnormal_mitochondrial_physio1.65453126
41MP0010155_abnormal_intestine_physiology1.62910257
42MP0003172_abnormal_lysosome_physiology1.60804322
43MP0003868_abnormal_feces_composition1.58111345
44MP0002148_abnormal_hypersensitivity_rea1.56587294
45MP0002971_abnormal_brown_adipose1.55372022
46MP0002723_abnormal_immune_serum1.55037313
47MP0003303_peritoneal_inflammation1.54335982
48MP0003718_maternal_effect1.53418663
49MP0001661_extended_life_span1.53334507
50MP0002452_abnormal_antigen_presenting1.50540361
51MP0002132_abnormal_respiratory_system1.44667491
52MP0001764_abnormal_homeostasis1.44202575
53MP0002166_altered_tumor_susceptibility1.42789489
54MP0001845_abnormal_inflammatory_respons1.42498958
55MP0002420_abnormal_adaptive_immunity1.41484239
56MP0001819_abnormal_immune_cell1.39722377
57MP0003186_abnormal_redox_activity1.37812396
58MP0005330_cardiomyopathy1.36986043
59MP0000604_amyloidosis1.36954506
60MP0009333_abnormal_splenocyte_physiolog1.36483529
61MP0002138_abnormal_hepatobiliary_system1.30685250
62MP0003075_altered_response_to1.28230519
63MP0005584_abnormal_enzyme/coenzyme_acti1.25696698
64MP0009643_abnormal_urine_homeostasis1.24303634
65MP0003300_gastrointestinal_ulcer1.23394829
66MP0003763_abnormal_thymus_physiology1.23169030
67MP0003011_delayed_dark_adaptation1.22757412
68MP0005647_abnormal_sex_gland1.22013678
69MP0001533_abnormal_skeleton_physiology1.18550492
70MP0009697_abnormal_copulation1.15728326
71MP0000343_altered_response_to1.15145838
72MP0004084_abnormal_cardiac_muscle1.14258827
73MP0003183_abnormal_peptide_metabolism1.13935785
74MP0005166_decreased_susceptibility_to1.12656475
75MP0003866_abnormal_defecation1.10195761
76MP0004215_abnormal_myocardial_fiber1.07693398
77MP0005266_abnormal_metabolism1.07415781
78MP0006035_abnormal_mitochondrial_morpho1.05265891
79MP0000716_abnormal_immune_system1.03982864
80MP0002405_respiratory_system_inflammati1.02955159
81MP0005375_adipose_tissue_phenotype0.99006987
82MP0004036_abnormal_muscle_relaxation0.97593202
83MP0004147_increased_porphyrin_level0.95439721
84MP0000858_altered_metastatic_potential0.94872141
85MP0006138_congestive_heart_failure0.94556302
86MP0002398_abnormal_bone_marrow0.94538146
87MP0000689_abnormal_spleen_morphology0.94022874
88MP0000566_synostosis0.93556838
89MP0005408_hypopigmentation0.92346425
90MP0004381_abnormal_hair_follicle0.92048201
91MP0002332_abnormal_exercise_endurance0.91677487
92MP0000598_abnormal_liver_morphology0.91415711
93MP0003221_abnormal_cardiomyocyte_apopto0.90818032
94MP0010368_abnormal_lymphatic_system0.90252545
95MP0005395_other_phenotype0.89777291
96MP0003950_abnormal_plasma_membrane0.87175736
97MP0002269_muscular_atrophy0.87149384
98MP0002722_abnormal_immune_system0.85806588
99MP0005165_increased_susceptibility_to0.84948890
100MP0004883_abnormal_blood_vessel0.84260475
101MP0005334_abnormal_fat_pad0.83893201
102MP0009763_increased_sensitivity_to0.82730832
103MP0002429_abnormal_blood_cell0.82151666
104MP0002078_abnormal_glucose_homeostasis0.82097082
105MP0009115_abnormal_fat_cell0.80932980
106MP0003705_abnormal_hypodermis_morpholog0.80272399
107MP0005376_homeostasis/metabolism_phenot0.80266244
108MP0000749_muscle_degeneration0.80080313
109MP0004947_skin_inflammation0.80037755
110MP0005397_hematopoietic_system_phenotyp0.79494833
111MP0001545_abnormal_hematopoietic_system0.79494833
112MP0002006_tumorigenesis0.79189664
113MP0005535_abnormal_body_temperature0.77929090
114MP0005164_abnormal_response_to0.77762672
115MP0000249_abnormal_blood_vessel0.76867931
116MP0005385_cardiovascular_system_phenoty0.76767735
117MP0001544_abnormal_cardiovascular_syste0.76767735
118MP0001851_eye_inflammation0.76090484
119MP0000372_irregular_coat_pigmentation0.75592192
120MP0004087_abnormal_muscle_fiber0.73096984
121MP0008260_abnormal_autophagy0.72987356
122MP0000579_abnormal_nail_morphology0.70899114
123MP0003656_abnormal_erythrocyte_physiolo0.69462263
124MP0008775_abnormal_heart_ventricle0.69038042
125MP0010630_abnormal_cardiac_muscle0.67747857
126MP0009642_abnormal_blood_homeostasis0.67444452
127MP0002796_impaired_skin_barrier0.67016120
128MP0005620_abnormal_muscle_contractility0.66964329
129MP0002254_reproductive_system_inflammat0.65805266
130MP0009764_decreased_sensitivity_to0.63200255
131MP0002876_abnormal_thyroid_physiology0.63076844
132MP0002970_abnormal_white_adipose0.62443193
133MP0002972_abnormal_cardiac_muscle0.62182698
134MP0005636_abnormal_mineral_homeostasis0.62034085
135MP0000750_abnormal_muscle_regeneration0.60023732
136MP0003137_abnormal_impulse_conducting0.57889911
137MP0001756_abnormal_urination0.57574969
138MP0002127_abnormal_cardiovascular_syste0.56737433
139MP0000462_abnormal_digestive_system0.56021891
140MP0008469_abnormal_protein_level0.52828629
141MP0000747_muscle_weakness0.52315149
142MP0005448_abnormal_energy_balance0.51552758
143MP0000751_myopathy0.48136726
144MP0003690_abnormal_glial_cell0.47788886
145MP0003828_pulmonary_edema0.46833242
146MP0004043_abnormal_pH_regulation0.46542690
147MP0002106_abnormal_muscle_physiology0.46469697
148MP0002060_abnormal_skin_morphology0.44912712
149MP0009765_abnormal_xenobiotic_induced0.44075633
150MP0003699_abnormal_female_reproductive0.43352374
151MP0003724_increased_susceptibility_to0.40820823
152MP0002136_abnormal_kidney_physiology0.39761268
153MP0000230_abnormal_systemic_arterial0.39664677

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)5.97680846
2Intrahepatic cholestasis (HP:0001406)5.62996570
3Hyperglycinemia (HP:0002154)5.35157389
4Abnormality of serine family amino acid metabolism (HP:0010894)5.34076655
5Abnormality of glycine metabolism (HP:0010895)5.34076655
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.17105409
7Xanthomatosis (HP:0000991)5.06425978
8Hypoglycemic coma (HP:0001325)4.87672618
9Deep venous thrombosis (HP:0002625)4.84289155
10Abnormality of fatty-acid metabolism (HP:0004359)4.77929147
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.72456250
12Hyperlipoproteinemia (HP:0010980)4.71566716
13* Hyperammonemia (HP:0001987)4.70533586
14Prolonged partial thromboplastin time (HP:0003645)4.66063133
15Hypoalphalipoproteinemia (HP:0003233)4.45003054
16Hypobetalipoproteinemia (HP:0003563)4.42971717
17* Abnormality of dicarboxylic acid metabolism (HP:0010995)4.29829425
18* Dicarboxylic aciduria (HP:0003215)4.29829425
19Hypolipoproteinemia (HP:0010981)4.19607682
20Ketosis (HP:0001946)4.19316670
21Recurrent gram-negative bacterial infections (HP:0005420)4.18649356
22Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.01025576
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.90666542
24Systemic lupus erythematosus (HP:0002725)3.87228000
25Abnormality of serum amino acid levels (HP:0003112)3.77306946
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.73121820
27Abnormality of methionine metabolism (HP:0010901)3.67132576
28Epidermoid cyst (HP:0200040)3.67081214
29Eczematoid dermatitis (HP:0000976)3.62736595
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.45135324
31* Lethargy (HP:0001254)3.38089024
32Cerebral edema (HP:0002181)3.36935041
33Gingival bleeding (HP:0000225)3.33444223
34Abnormality of glutamine family amino acid metabolism (HP:0010902)3.32157215
35Complement deficiency (HP:0004431)3.31083506
36Recurrent abscess formation (HP:0002722)3.28604604
37Ketoacidosis (HP:0001993)3.28260614
38Joint hemorrhage (HP:0005261)3.14119725
39Abnormality of macrophages (HP:0004311)3.10525463
40Generalized aminoaciduria (HP:0002909)3.09328280
41Renal cortical cysts (HP:0000803)3.06176557
42Myoglobinuria (HP:0002913)3.01828952
43Metabolic acidosis (HP:0001942)2.96457945
44Fat malabsorption (HP:0002630)2.89404385
45Proximal tubulopathy (HP:0000114)2.84132630
46Gout (HP:0001997)2.80649065
47* Rhabdomyolysis (HP:0003201)2.78126723
48Nausea (HP:0002018)2.76748398
49Abnormality of the common coagulation pathway (HP:0010990)2.70252578
50Abnormality of pyrimidine metabolism (HP:0004353)2.68675005
51Hypercholesterolemia (HP:0003124)2.66815873
52Abnormality of the intrinsic pathway (HP:0010989)2.66585055
53Hepatic necrosis (HP:0002605)2.65030533
54Abnormality of nucleobase metabolism (HP:0010932)2.64671274
55Recurrent bacterial skin infections (HP:0005406)2.63997504
56Abnormality of purine metabolism (HP:0004352)2.62669409
57Glomerulonephritis (HP:0000099)2.61128994
58Abnormality of glycolipid metabolism (HP:0010969)2.60324888
59Abnormality of liposaccharide metabolism (HP:0010968)2.60324888
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.60324888
61Vacuolated lymphocytes (HP:0001922)2.56163142
62Chronic obstructive pulmonary disease (HP:0006510)2.51980720
63Obstructive lung disease (HP:0006536)2.51980720
64Hyperglycemia (HP:0003074)2.51867749
65Conjugated hyperbilirubinemia (HP:0002908)2.50565236
66Myocardial infarction (HP:0001658)2.47930605
67Meningitis (HP:0001287)2.44307815
68Hyperuricemia (HP:0002149)2.40953621
69Increased purine levels (HP:0004368)2.40953621
70Delayed CNS myelination (HP:0002188)2.38307321
71Purpura (HP:0000979)2.37959261
72Vomiting (HP:0002013)2.36943426
73Cerebral palsy (HP:0100021)2.36362108
74Right ventricular cardiomyopathy (HP:0011663)2.34988559
75Epistaxis (HP:0000421)2.34833619
76Myositis (HP:0100614)2.32518888
77Spontaneous abortion (HP:0005268)2.32024890
78Recurrent fungal infections (HP:0002841)2.28857176
79Joint swelling (HP:0001386)2.28054634
80Gingivitis (HP:0000230)2.27258021
81Skin nodule (HP:0200036)2.26017092
82Amyloidosis (HP:0011034)2.24747033
83Gastrointestinal infarctions (HP:0005244)2.23590269
84Asymmetric septal hypertrophy (HP:0001670)2.21435516
85Hyperinsulinemic hypoglycemia (HP:0000825)2.20814342
86Abnormality of complement system (HP:0005339)2.18843128
87Abnormal cartilage morphology (HP:0002763)2.16337871
88Hyperbilirubinemia (HP:0002904)2.16110863
89Exercise-induced myalgia (HP:0003738)2.15016867
90Petechiae (HP:0000967)2.14553062
91Nemaline bodies (HP:0003798)2.14530087
92Steatorrhea (HP:0002570)2.14422022
93Elevated erythrocyte sedimentation rate (HP:0003565)2.13761002
94Hypochromic microcytic anemia (HP:0004840)2.13672330
95Increased muscle lipid content (HP:0009058)2.12020958
96Dysostosis multiplex (HP:0000943)2.10735608
97Sensorimotor neuropathy (HP:0007141)2.10067065
98Muscle fiber inclusion bodies (HP:0100299)2.09478952
99Muscle fiber splitting (HP:0003555)2.09095686
100Increased serum ferritin (HP:0003281)2.08939868
101Abnormality of urine glucose concentration (HP:0011016)2.08267713
102Glycosuria (HP:0003076)2.08267713
103Hepatocellular carcinoma (HP:0001402)2.08050410
104Orchitis (HP:0100796)2.07325178
105Acute encephalopathy (HP:0006846)2.07244743
106Abnormality of proline metabolism (HP:0010907)2.07043546
107Hydroxyprolinuria (HP:0003080)2.07043546
108Chronic diarrhea (HP:0002028)2.06557070
109Brushfield spots (HP:0001088)2.06330457
110Abnormality of iron homeostasis (HP:0011031)2.05603873
111Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.04512441
112Methylmalonic aciduria (HP:0012120)2.03142050
113Abnormality of T cell number (HP:0011839)2.02824500
114Granulocytopenia (HP:0001913)2.02416822
115Abnormality of glycolysis (HP:0004366)2.02325010
116Increased serum pyruvate (HP:0003542)2.02325010
117Malnutrition (HP:0004395)2.01218165
118Pancreatitis (HP:0001733)2.01153538
119Thrombophlebitis (HP:0004418)2.01135514
120Mucopolysacchariduria (HP:0008155)2.00954840
121Urinary glycosaminoglycan excretion (HP:0003541)2.00954840
122T lymphocytopenia (HP:0005403)2.00566188
123Autoimmune hemolytic anemia (HP:0001890)2.00139772
124Pulmonary embolism (HP:0002204)2.00093016
125Prolonged bleeding time (HP:0003010)1.99982690
126Recurrent skin infections (HP:0001581)1.99859718
127Vasculitis (HP:0002633)1.99836383
128Abnormality of lateral ventricle (HP:0030047)1.99618582
129Skin rash (HP:0000988)1.98645396
130Chest pain (HP:0100749)1.98524965
131Hypoglycemic seizures (HP:0002173)1.98408305
132Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98042492
133Abnormality of polysaccharide metabolism (HP:0011012)1.98042492
134Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98042492
135Hypertriglyceridemia (HP:0002155)1.97591583
136Vascular calcification (HP:0004934)1.97016893
137Lactic acidosis (HP:0003128)1.94561783
138Encephalitis (HP:0002383)1.94439712
139* Ventricular tachycardia (HP:0004756)1.93968932
140Sudden death (HP:0001699)1.92893070
141* Irritability (HP:0000737)1.92640802
142Periodontitis (HP:0000704)1.91998981
143Eosinophilia (HP:0001880)1.91001862
144Centrally nucleated skeletal muscle fibers (HP:0003687)1.88490088
145Nephritis (HP:0000123)1.88229477
146Hypoproteinemia (HP:0003075)1.87859630
147Abnormality of vitamin metabolism (HP:0100508)1.86906859
148Reduced antithrombin III activity (HP:0001976)1.86473875
149Urticaria (HP:0001025)1.86391878
150Abnormality of transition element cation homeostasis (HP:0011030)1.86206866
151Spontaneous hematomas (HP:0007420)1.85933844
152Autoimmune thrombocytopenia (HP:0001973)1.85587575
153Hemoptysis (HP:0002105)1.85507563
154Increased IgM level (HP:0003496)1.85353428
155Abnormal delayed hypersensitivity skin test (HP:0002963)1.84984329
156Palpitations (HP:0001962)1.84612720
157Hemorrhage of the eye (HP:0011885)1.84472908
158Respiratory distress (HP:0002098)1.83905694
159* Atrioventricular block (HP:0001678)1.81859935
160Esophageal varix (HP:0002040)1.81333760
161Hyporeflexia of lower limbs (HP:0002600)1.79793870
162* Elevated hepatic transaminases (HP:0002910)1.77749316
163Insulin-resistant diabetes mellitus (HP:0000831)1.77595401
164Abnormality of the gallbladder (HP:0005264)1.74465787
165Acute hepatic failure (HP:0006554)1.71277240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.53550407
2LATS13.49790947
3STK38L3.20104494
4RIPK43.16012740
5PDK43.01785660
6PDK33.01785660
7MAP4K12.60197903
8BLK2.51843525
9TXK2.49294487
10LATS22.41845147
11CDK122.34104755
12ERBB42.32147258
13MST1R2.20552540
14TESK22.19047977
15ZAP702.07550235
16FGFR42.06827396
17JAK32.02883082
18SIK11.95197411
19IRAK31.94710385
20INSRR1.93365720
21PINK11.92511477
22AKT31.92017214
23PDK21.90692336
24OBSCN1.88884871
25FES1.85542313
26PRKAA21.80010660
27SCYL21.74397409
28SYK1.73161357
29TTK1.68474232
30GRK61.65410387
31CSK1.60712362
32STK31.55934872
33TBK11.55639875
34EPHA21.54569300
35MUSK1.54089809
36CAMK1D1.53620349
37ZAK1.51163500
38MAPK111.47824532
39TTN1.46682657
40JAK11.43462498
41MAP3K141.43241956
42BUB11.41670029
43ITK1.41036895
44PRPF4B1.40754305
45KIT1.40351337
46BTK1.39925073
47MET1.37743000
48PIK3CA1.36079412
49PLK41.35489630
50TNK21.33368526
51ABL21.27195113
52TEC1.22213058
53LYN1.21100534
54PRKAA11.20970020
55TIE11.19530079
56MAPKAPK31.18910094
57CSF1R1.17988522
58MAP3K111.17578621
59LCK1.10065179
60PIM21.03894846
61MAP3K60.98695909
62TGFBR20.97146372
63PDK10.94882069
64IKBKE0.94301390
65TESK10.94256400
66HCK0.92441473
67IRAK40.91283197
68BMPR20.91092142
69STK40.90550123
70MAP3K130.89691126
71MAP2K30.88276500
72TAOK30.85934493
73PBK0.83552111
74FGFR30.83469870
75IKBKB0.82817049
76ERN10.82644491
77MAP3K10.82634714
78KDR0.82320826
79NEK10.81598382
80GRK10.81122176
81WEE10.80500995
82PRKG20.80341821
83MAP3K30.78946486
84TYK20.78759281
85DYRK30.78351004
86PIK3CG0.78349969
87CAMKK20.77940533
88LRRK20.77683712
89STK240.77387483
90MAPK70.77045067
91PHKG10.76224695
92PHKG20.76224695
93MAP2K40.75274524
94GRK70.73376412
95FLT30.72837242
96PRKCQ0.71545802
97MYLK0.70909301
98BRD40.70534053
99NME20.70350661
100MATK0.69347443
101RPS6KB20.68670982
102EIF2AK20.68178185
103FGR0.67701321
104MAPK120.67608051
105MAP2K20.67572715
106LMTK20.65578069
107KSR20.65267709
108NEK20.64530855
109ACVR1B0.64455983
110TRIB30.64433985
111STK380.64142826
112PKN10.64076901
113TAOK20.63319265
114CDK90.62355456
115MELK0.62113702
116MTOR0.59523570
117PAK30.58622129
118EPHA30.58546988
119DYRK1B0.57864927
120MAP3K50.57236845
121BRAF0.56123037
122MAP3K120.55913063
123TAOK10.55434001
124CDK60.54990352
125CDK40.53713770
126PIM10.53006280
127NLK0.52763418
128SRPK10.50377380
129EPHB10.49191107
130PLK10.48348656
131IGF1R0.48294898
132PRKACG0.47940301
133AURKB0.47216360
134EIF2AK30.46862794
135CAMK2G0.44479305
136PDPK10.44111188
137MAP3K20.43803058
138NEK90.43359880
139MAPK40.42799858
140STK160.42742782
141MAP2K10.41946999
142FYN0.41461761
143MAP3K70.40988113
144CAMK1G0.40530140
145MAP2K60.40505361
146GSK3A0.40143533
147CHEK20.39948490
148ICK0.39142025
149STK390.38615798
150FGFR20.38062117
151JAK20.36715382
152PRKD10.36597740
153IRAK10.36431341
154PRKCD0.35053496
155MAPKAPK20.35014424
156RPS6KC10.34348735
157IRAK20.34343915
158CDK70.34047319
159AKT20.33785999
160CAMK2D0.33638732
161TRPM70.32652830
162DYRK20.31085260

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.31339163
2Fatty acid degradation_Homo sapiens_hsa000713.21522957
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.08699696
4Propanoate metabolism_Homo sapiens_hsa006402.96530539
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.86452279
6Fatty acid metabolism_Homo sapiens_hsa012122.58703092
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.58364609
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48303996
9Tryptophan metabolism_Homo sapiens_hsa003802.45206684
10Butanoate metabolism_Homo sapiens_hsa006502.41288672
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40154499
12Arginine biosynthesis_Homo sapiens_hsa002202.40085631
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34405389
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.31791504
15Nitrogen metabolism_Homo sapiens_hsa009102.29923930
16PPAR signaling pathway_Homo sapiens_hsa033202.19549712
17Vitamin B6 metabolism_Homo sapiens_hsa007502.18453373
18Fatty acid elongation_Homo sapiens_hsa000622.13317263
19Peroxisome_Homo sapiens_hsa041462.04379997
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93715274
21beta-Alanine metabolism_Homo sapiens_hsa004101.92990621
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.92103319
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85697631
24Allograft rejection_Homo sapiens_hsa053301.84661758
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84244707
26Complement and coagulation cascades_Homo sapiens_hsa046101.80859989
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80723970
28Autoimmune thyroid disease_Homo sapiens_hsa053201.79505611
29Graft-versus-host disease_Homo sapiens_hsa053321.76898862
30Carbon metabolism_Homo sapiens_hsa012001.73960674
31Other glycan degradation_Homo sapiens_hsa005111.73466191
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66026775
33Pyruvate metabolism_Homo sapiens_hsa006201.65109153
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64285954
35Retinol metabolism_Homo sapiens_hsa008301.60650812
36Histidine metabolism_Homo sapiens_hsa003401.56775021
37Chemical carcinogenesis_Homo sapiens_hsa052041.55834179
38Primary immunodeficiency_Homo sapiens_hsa053401.47701472
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45601653
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.44878491
41Type I diabetes mellitus_Homo sapiens_hsa049401.42151341
42Leishmaniasis_Homo sapiens_hsa051401.41378639
43Biosynthesis of amino acids_Homo sapiens_hsa012301.40443625
44Sulfur metabolism_Homo sapiens_hsa009201.40008196
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.39247574
46Folate biosynthesis_Homo sapiens_hsa007901.35790752
47Asthma_Homo sapiens_hsa053101.34058057
48Caffeine metabolism_Homo sapiens_hsa002321.30632223
49Phenylalanine metabolism_Homo sapiens_hsa003601.29714660
50Antigen processing and presentation_Homo sapiens_hsa046121.29610293
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.28986519
52Tyrosine metabolism_Homo sapiens_hsa003501.24691514
53Selenocompound metabolism_Homo sapiens_hsa004501.22763642
54Arginine and proline metabolism_Homo sapiens_hsa003301.18542132
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.17008690
56Starch and sucrose metabolism_Homo sapiens_hsa005001.13230097
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.11876116
58Fatty acid biosynthesis_Homo sapiens_hsa000611.07679249
59Pentose phosphate pathway_Homo sapiens_hsa000301.07540855
60Fat digestion and absorption_Homo sapiens_hsa049751.05654005
61Viral myocarditis_Homo sapiens_hsa054161.05047319
62Staphylococcus aureus infection_Homo sapiens_hsa051501.03445230
63Vitamin digestion and absorption_Homo sapiens_hsa049771.02661749
64Bile secretion_Homo sapiens_hsa049761.00035471
65Glycerolipid metabolism_Homo sapiens_hsa005610.99961878
66Steroid biosynthesis_Homo sapiens_hsa001000.98587278
67Lysine degradation_Homo sapiens_hsa003100.98292444
68ABC transporters_Homo sapiens_hsa020100.96620974
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92068251
70Sulfur relay system_Homo sapiens_hsa041220.90744552
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89125406
72Lysosome_Homo sapiens_hsa041420.88669987
73Pertussis_Homo sapiens_hsa051330.85595507
74Rheumatoid arthritis_Homo sapiens_hsa053230.84040355
75Hematopoietic cell lineage_Homo sapiens_hsa046400.79818421
76Glutathione metabolism_Homo sapiens_hsa004800.79421373
77Renin-angiotensin system_Homo sapiens_hsa046140.78780309
78Osteoclast differentiation_Homo sapiens_hsa043800.77832640
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77665782
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75481763
81Tuberculosis_Homo sapiens_hsa051520.74846141
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72818257
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69999580
84Phagosome_Homo sapiens_hsa041450.68204066
85Metabolic pathways_Homo sapiens_hsa011000.68054091
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.67802060
87Linoleic acid metabolism_Homo sapiens_hsa005910.67726207
88Malaria_Homo sapiens_hsa051440.67342856
89One carbon pool by folate_Homo sapiens_hsa006700.66427429
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.64649480
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63380417
92Legionellosis_Homo sapiens_hsa051340.62107221
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.58233150
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55521239
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55301387
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51951397
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51908826
98B cell receptor signaling pathway_Homo sapiens_hsa046620.48223357
99Measles_Homo sapiens_hsa051620.44463555
100Oxidative phosphorylation_Homo sapiens_hsa001900.42407893
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.41982563
102Fructose and mannose metabolism_Homo sapiens_hsa000510.40637019
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.37948468
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37654221
105Toxoplasmosis_Homo sapiens_hsa051450.37413772
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36827963
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32959224
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31768527
109Regulation of autophagy_Homo sapiens_hsa041400.30535625
110Galactose metabolism_Homo sapiens_hsa000520.29682228
111Insulin resistance_Homo sapiens_hsa049310.28470531
112Parkinsons disease_Homo sapiens_hsa050120.28208428
113RNA polymerase_Homo sapiens_hsa030200.26533176
114AMPK signaling pathway_Homo sapiens_hsa041520.26375237
115Arachidonic acid metabolism_Homo sapiens_hsa005900.23468209
116Huntingtons disease_Homo sapiens_hsa050160.20456438
117Glucagon signaling pathway_Homo sapiens_hsa049220.17691020
118Ether lipid metabolism_Homo sapiens_hsa005650.12764476
119Ovarian steroidogenesis_Homo sapiens_hsa049130.11480763
120Pyrimidine metabolism_Homo sapiens_hsa002400.09328149
121Alzheimers disease_Homo sapiens_hsa050100.08717866
122Cardiac muscle contraction_Homo sapiens_hsa042600.07688589
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.05246291
124Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0892324
125Fanconi anemia pathway_Homo sapiens_hsa03460-0.0856499
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0758624
127Mineral absorption_Homo sapiens_hsa04978-0.0516472
128Purine metabolism_Homo sapiens_hsa00230-0.0270073
129Circadian rhythm_Homo sapiens_hsa04710-0.0243036
130Prion diseases_Homo sapiens_hsa05020-0.0226688
131Insulin signaling pathway_Homo sapiens_hsa04910-0.0027450

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