SLC25A21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)6.66258280
2protoporphyrinogen IX biosynthetic process (GO:0006782)6.54006366
3heme biosynthetic process (GO:0006783)5.83269632
4heme metabolic process (GO:0042168)5.40525887
5cysteine metabolic process (GO:0006534)5.37967051
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.32817304
7L-phenylalanine catabolic process (GO:0006559)5.32817304
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.27817250
9L-phenylalanine metabolic process (GO:0006558)5.27817250
10aromatic amino acid family catabolic process (GO:0009074)5.16739035
11tryptophan catabolic process (GO:0006569)5.03303978
12indole-containing compound catabolic process (GO:0042436)5.03303978
13indolalkylamine catabolic process (GO:0046218)5.03303978
14porphyrin-containing compound biosynthetic process (GO:0006779)5.02962018
15tryptophan metabolic process (GO:0006568)4.74941376
16porphyrin-containing compound metabolic process (GO:0006778)4.69866411
17tetrapyrrole biosynthetic process (GO:0033014)4.63553758
18kynurenine metabolic process (GO:0070189)4.62688437
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.43018359
20glyoxylate metabolic process (GO:0046487)4.28248841
21bile acid biosynthetic process (GO:0006699)4.15566360
22serine family amino acid catabolic process (GO:0009071)4.14505000
23imidazole-containing compound metabolic process (GO:0052803)4.09961853
24glycine metabolic process (GO:0006544)4.07080918
25sulfur amino acid catabolic process (GO:0000098)4.03381871
26serine family amino acid metabolic process (GO:0009069)4.02679915
27high-density lipoprotein particle remodeling (GO:0034375)3.95930527
28serine family amino acid biosynthetic process (GO:0009070)3.93147118
29urea metabolic process (GO:0019627)3.92687295
30urea cycle (GO:0000050)3.92687295
31* lysine catabolic process (GO:0006554)3.91719449
32* lysine metabolic process (GO:0006553)3.91719449
33folic acid metabolic process (GO:0046655)3.90001795
34blood coagulation, intrinsic pathway (GO:0007597)3.88269656
35cofactor catabolic process (GO:0051187)3.88236772
36DNA deamination (GO:0045006)3.87246987
37amino-acid betaine metabolic process (GO:0006577)3.86479409
38aromatic amino acid family metabolic process (GO:0009072)3.79652003
39cellular biogenic amine catabolic process (GO:0042402)3.78424241
40amine catabolic process (GO:0009310)3.78424241
41alpha-linolenic acid metabolic process (GO:0036109)3.78206903
42protein-cofactor linkage (GO:0018065)3.72737872
43regulation of protein activation cascade (GO:2000257)3.70964215
44ethanol oxidation (GO:0006069)3.69915006
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.69573877
46homocysteine metabolic process (GO:0050667)3.69485300
47very-low-density lipoprotein particle assembly (GO:0034379)3.69045594
48nitrogen cycle metabolic process (GO:0071941)3.68900456
49* alpha-amino acid catabolic process (GO:1901606)3.68599730
50water-soluble vitamin biosynthetic process (GO:0042364)3.68474309
51peptidyl-glutamic acid carboxylation (GO:0017187)3.68150414
52protein carboxylation (GO:0018214)3.68150414
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.65632763
54maturation of 5.8S rRNA (GO:0000460)3.63703649
55cellular ketone body metabolic process (GO:0046950)3.62548956
56indolalkylamine metabolic process (GO:0006586)3.59671408
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.59512027
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.59512027
59NADH dehydrogenase complex assembly (GO:0010257)3.59512027
60NAD biosynthetic process (GO:0009435)3.58069615
61ATP synthesis coupled proton transport (GO:0015986)3.56801794
62energy coupled proton transport, down electrochemical gradient (GO:0015985)3.56801794
63one-carbon metabolic process (GO:0006730)3.54614795
64nicotinamide nucleotide biosynthetic process (GO:0019359)3.53186715
65pyridine nucleotide biosynthetic process (GO:0019363)3.53186715
66bile acid metabolic process (GO:0008206)3.52732531
67negative regulation of fibrinolysis (GO:0051918)3.50543313
68response to nitrosative stress (GO:0051409)3.50531845
69protein complex biogenesis (GO:0070271)3.49813999
70drug transmembrane transport (GO:0006855)3.49670959
71urate metabolic process (GO:0046415)3.49612301
72regulation of complement activation (GO:0030449)3.48187715
73reverse cholesterol transport (GO:0043691)3.47348667
74mitochondrial respiratory chain complex assembly (GO:0033108)3.46273769
75plasma lipoprotein particle assembly (GO:0034377)3.39605345
76regulation of fibrinolysis (GO:0051917)3.39269553
77response to pheromone (GO:0019236)3.39105181
78protein autoprocessing (GO:0016540)3.38649558
79mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36392874
80proteasome assembly (GO:0043248)3.33632320
81* cellular amino acid catabolic process (GO:0009063)3.32323548
82heme transport (GO:0015886)3.32265641
83one-carbon compound transport (GO:0019755)3.31798518
84folic acid-containing compound biosynthetic process (GO:0009396)3.30910637
85erythrocyte maturation (GO:0043249)3.28787694
86cellular glucuronidation (GO:0052695)3.27990179
87tetrapyrrole metabolic process (GO:0033013)3.27846058
88behavioral response to nicotine (GO:0035095)3.27212303
89plasma lipoprotein particle remodeling (GO:0034369)3.26674923
90protein-lipid complex remodeling (GO:0034368)3.26674923
91macromolecular complex remodeling (GO:0034367)3.26674923
92pseudouridine synthesis (GO:0001522)3.26536479
93regulation of cholesterol esterification (GO:0010872)3.26218078
94DNA double-strand break processing (GO:0000729)3.25422385
95glutamate metabolic process (GO:0006536)3.24876579
96respiratory chain complex IV assembly (GO:0008535)3.24307204
97drug transport (GO:0015893)3.23005836
98complement activation, alternative pathway (GO:0006957)3.22841081
99establishment of protein localization to mitochondrial membrane (GO:0090151)3.22784737
100replication fork processing (GO:0031297)3.19910010
101sulfur amino acid metabolic process (GO:0000096)3.19257229
102chromatin remodeling at centromere (GO:0031055)3.17884864
103response to mercury ion (GO:0046689)3.16129155
104regulation of triglyceride catabolic process (GO:0010896)3.15452354
105tyrosine metabolic process (GO:0006570)3.15423925
106aldehyde catabolic process (GO:0046185)3.14599777
107bile acid and bile salt transport (GO:0015721)3.13894077
108centriole replication (GO:0007099)3.13828730
109coenzyme catabolic process (GO:0009109)3.13422058
110phospholipid efflux (GO:0033700)3.13190933
111DNA replication checkpoint (GO:0000076)3.11375315
112tetrahydrofolate metabolic process (GO:0046653)3.09947551
113pigment metabolic process (GO:0042440)3.08552622
114arginine metabolic process (GO:0006525)3.08013310
115ketone body metabolic process (GO:1902224)3.07800228
116negative regulation of telomere maintenance (GO:0032205)3.07698630
117peptidyl-histidine modification (GO:0018202)3.07335000
118benzene-containing compound metabolic process (GO:0042537)3.07169286
119negative regulation of DNA-dependent DNA replication (GO:2000104)3.06683709
120sulfur amino acid biosynthetic process (GO:0000097)3.06433389
121valine metabolic process (GO:0006573)3.06348050
122synapsis (GO:0007129)3.05268306
123short-chain fatty acid metabolic process (GO:0046459)3.04688336
124termination of RNA polymerase III transcription (GO:0006386)3.04309152
125transcription elongation from RNA polymerase III promoter (GO:0006385)3.04309152
126nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03376188
127regulation of nuclear cell cycle DNA replication (GO:0033262)3.03241205
128cofactor biosynthetic process (GO:0051188)3.02648386
129carnitine metabolic process (GO:0009437)3.01750419
130somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01550796
131somatic hypermutation of immunoglobulin genes (GO:0016446)3.01550796
132pigment biosynthetic process (GO:0046148)3.01454108
133chaperone-mediated protein transport (GO:0072321)2.97016205
134exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96550219
135platelet dense granule organization (GO:0060155)2.95722199
136CENP-A containing nucleosome assembly (GO:0034080)2.94188054
137regulation of mitotic spindle checkpoint (GO:1903504)2.91658380
138regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91658380
139cullin deneddylation (GO:0010388)2.88071615
140epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.87413228
141preassembly of GPI anchor in ER membrane (GO:0016254)2.87249137
142intracellular protein transmembrane import (GO:0044743)2.84378246
143epithelial cilium movement (GO:0003351)2.83900687
144cytochrome complex assembly (GO:0017004)2.81833855
145tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81776527
146RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81776527
147tRNA processing (GO:0008033)2.79097565
148reciprocal meiotic recombination (GO:0007131)2.77750364
149reciprocal DNA recombination (GO:0035825)2.77750364
150mannosylation (GO:0097502)2.77475132
151electron transport chain (GO:0022900)2.77148128
152nonmotile primary cilium assembly (GO:0035058)2.74905518
153respiratory electron transport chain (GO:0022904)2.74739070
154recombinational repair (GO:0000725)2.74304445
155protein deneddylation (GO:0000338)2.73521488
156mitochondrial RNA metabolic process (GO:0000959)2.72284045
157double-strand break repair via homologous recombination (GO:0000724)2.71664835
158L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66229187
159protein neddylation (GO:0045116)2.62220593
160histone exchange (GO:0043486)2.61746007
161rRNA modification (GO:0000154)2.61576911
162nucleobase biosynthetic process (GO:0046112)2.61031891
163rRNA catabolic process (GO:0016075)2.60815189
164RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58704012
165resolution of meiotic recombination intermediates (GO:0000712)2.58468991
166purine nucleobase biosynthetic process (GO:0009113)2.58175796
167somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.57291891
168somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.57291891
169isotype switching (GO:0045190)2.57291891
170tRNA modification (GO:0006400)2.57036838
171regulation of glucokinase activity (GO:0033131)2.56807810
172regulation of hexokinase activity (GO:1903299)2.56807810
173ubiquinone biosynthetic process (GO:0006744)2.56775390
174regulation of mitochondrial translation (GO:0070129)2.55470033
175DNA catabolic process, exonucleolytic (GO:0000738)2.55402667
176tRNA metabolic process (GO:0006399)2.54705437
177maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.53276789
178meiotic chromosome segregation (GO:0045132)2.53226815
179regulation of cilium movement (GO:0003352)2.52937026
180regulation of meiosis I (GO:0060631)2.51143662
181protein K6-linked ubiquitination (GO:0085020)2.49872858
182axoneme assembly (GO:0035082)2.49464877
183intraciliary transport (GO:0042073)2.47550886
184ubiquinone metabolic process (GO:0006743)2.45976183
185ATP biosynthetic process (GO:0006754)2.44556485
186base-excision repair, AP site formation (GO:0006285)2.43532125
187branched-chain amino acid catabolic process (GO:0009083)2.43465890
188nucleotide transmembrane transport (GO:1901679)2.43322288
189L-fucose catabolic process (GO:0042355)2.41801136
190fucose catabolic process (GO:0019317)2.41801136
191L-fucose metabolic process (GO:0042354)2.41801136
192kinetochore assembly (GO:0051382)2.41222982
193protein import into peroxisome matrix (GO:0016558)2.40958461
194detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.40106163
195cilium morphogenesis (GO:0060271)2.38815077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.45579121
2E2F7_22180533_ChIP-Seq_HELA_Human5.66840342
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.79120842
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.77929608
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.18419545
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.02532012
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.81954884
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.56354804
9* ZNF274_21170338_ChIP-Seq_K562_Hela3.28590588
10LXR_22158963_ChIP-Seq_LIVER_Mouse3.26073218
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11504734
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.03722035
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86250574
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.80114037
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.76654418
16GATA1_22025678_ChIP-Seq_K562_Human2.58257388
17VDR_22108803_ChIP-Seq_LS180_Human2.57649896
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.53684358
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.35745040
20IGF1R_20145208_ChIP-Seq_DFB_Human2.27762724
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25490599
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24640727
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.21877747
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.14165428
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13517957
26EWS_26573619_Chip-Seq_HEK293_Human2.07009669
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04956527
28AR_21909140_ChIP-Seq_LNCAP_Human2.01976262
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00473486
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.97507779
31FUS_26573619_Chip-Seq_HEK293_Human1.94271410
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.93867192
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93077207
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89405876
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88447106
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85036502
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73961340
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72881523
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72585104
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70599534
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.66611581
42SCL_19346495_ChIP-Seq_HPC-7_Human1.66009174
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.65286490
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63490477
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62690069
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61852469
47VDR_23849224_ChIP-Seq_CD4+_Human1.61755624
48* GATA1_19941827_ChIP-Seq_MEL_Mouse1.61480745
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.60786505
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60603309
51GATA1_22383799_ChIP-Seq_G1ME_Mouse1.56309790
52TAF15_26573619_Chip-Seq_HEK293_Human1.54280553
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54248488
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54062317
55DCP1A_22483619_ChIP-Seq_HELA_Human1.53651798
56* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52876100
57GBX2_23144817_ChIP-Seq_PC3_Human1.51218107
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49415463
59TP53_22573176_ChIP-Seq_HFKS_Human1.48202887
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46689940
61FOXP3_21729870_ChIP-Seq_TREG_Human1.46305535
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45597606
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45527983
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44486936
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43249206
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.42941824
67* GABP_19822575_ChIP-Seq_HepG2_Human1.42194954
68P300_19829295_ChIP-Seq_ESCs_Human1.41409201
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39365079
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37925798
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.37710194
72TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.37176998
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33977690
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33208854
75ER_23166858_ChIP-Seq_MCF-7_Human1.32747605
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31814875
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30353480
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30107816
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27577549
80XRN2_22483619_ChIP-Seq_HELA_Human1.24956037
81KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24276673
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21566853
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20061882
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.20061882
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16245079
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.16057848
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15652932
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15609245
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15447123
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15129247
91MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11820204
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.11284610
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10612214
94GATA1_19941826_ChIP-Seq_K562_Human1.10039679
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.08604824
96IRF1_19129219_ChIP-ChIP_H3396_Human1.07038756
97AR_20517297_ChIP-Seq_VCAP_Human1.06857511
98CBP_20019798_ChIP-Seq_JUKART_Human1.06326138
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06326138
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06112328
101SOX2_19829295_ChIP-Seq_ESCs_Human1.06073711
102NANOG_19829295_ChIP-Seq_ESCs_Human1.06073711
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05978871
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05442126
105* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05431050
106EZH2_22144423_ChIP-Seq_EOC_Human1.04982727
107NCOR_22424771_ChIP-Seq_293T_Human1.02939807
108MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01889987
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00852273
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.00097396
111* GATA3_21878914_ChIP-Seq_MCF-7_Human1.00023124
112ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99291394
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98772435
114CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96495750
115KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95469146
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95270092
117HOXB7_26014856_ChIP-Seq_BT474_Human0.94923220
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94601728
119* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94176764
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93958803
121CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92612622
122IRF8_22096565_ChIP-ChIP_GC-B_Human0.92465768
123ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91617705
124FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90258996
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89390681
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89352897
127KDM5A_27292631_Chip-Seq_BREAST_Human0.88446519
128RNF2_27304074_Chip-Seq_NSC_Mouse0.88228955
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88185811
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88018971
131MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86846825
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86445252
133SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86422459
134STAT3_23295773_ChIP-Seq_U87_Human0.86369903
135TCF4_22108803_ChIP-Seq_LS180_Human0.86046478
136RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85922667
137MYC_18940864_ChIP-ChIP_HL60_Human0.85368083
138GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84074504
139STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83316839
140HTT_18923047_ChIP-ChIP_STHdh_Human0.80639291
141CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79819778
142TTF2_22483619_ChIP-Seq_HELA_Human0.79006125
143ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76143315
144KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75803410
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75782672
146ELK1_19687146_ChIP-ChIP_HELA_Human0.75210882
147TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74827087
148NANOG_18555785_ChIP-Seq_MESCs_Mouse0.74361153
149LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.72689850
150CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.72566640
151* HNF4A_19822575_ChIP-Seq_HepG2_Human0.72470117
152RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.71422010
153ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71103040
154GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69082211
155IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.68815663
156SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68110564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.76610113
2MP0003656_abnormal_erythrocyte_physiolo5.75856273
3MP0005360_urolithiasis5.74256348
4MP0003806_abnormal_nucleotide_metabolis5.12113456
5MP0005085_abnormal_gallbladder_physiolo4.91316700
6MP0004147_increased_porphyrin_level4.55967931
7MP0005365_abnormal_bile_salt4.39768930
8MP0008875_abnormal_xenobiotic_pharmacok3.68522862
9MP0008877_abnormal_DNA_methylation3.08287575
10MP0003252_abnormal_bile_duct2.58748580
11MP0003186_abnormal_redox_activity2.55800045
12MP0010329_abnormal_lipoprotein_level2.53478555
13MP0006054_spinal_hemorrhage2.46734560
14MP0005083_abnormal_biliary_tract2.44872480
15MP0005332_abnormal_amino_acid2.35732263
16MP0003195_calcinosis2.28099761
17MP0006072_abnormal_retinal_apoptosis2.21466263
18MP0009840_abnormal_foam_cell2.19481059
19MP0009697_abnormal_copulation2.19256242
20MP0002837_dystrophic_cardiac_calcinosis2.13900194
21MP0001764_abnormal_homeostasis2.07969820
22MP0000372_irregular_coat_pigmentation2.06120316
23MP0003136_yellow_coat_color2.03409329
24MP0001529_abnormal_vocalization2.02278616
25MP0002138_abnormal_hepatobiliary_system2.00417598
26MP0002132_abnormal_respiratory_system2.00184355
27MP0005551_abnormal_eye_electrophysiolog1.89898318
28MP0005636_abnormal_mineral_homeostasis1.83677677
29MP0008995_early_reproductive_senescence1.82198280
30MP0000609_abnormal_liver_physiology1.81883387
31MP0001666_abnormal_nutrient_absorption1.81613180
32MP0005645_abnormal_hypothalamus_physiol1.76537163
33MP0003787_abnormal_imprinting1.75354211
34MP0006036_abnormal_mitochondrial_physio1.74996003
35MP0005319_abnormal_enzyme/_coenzyme1.72823914
36MP0004019_abnormal_vitamin_homeostasis1.67251891
37MP0005253_abnormal_eye_physiology1.65011036
38MP0001545_abnormal_hematopoietic_system1.64196820
39MP0005397_hematopoietic_system_phenotyp1.64196820
40MP0004133_heterotaxia1.63324522
41MP0002160_abnormal_reproductive_system1.60633754
42MP0002653_abnormal_ependyma_morphology1.60158282
43MP0003868_abnormal_feces_composition1.54622701
44MP0006276_abnormal_autonomic_nervous1.50487572
45MP0003646_muscle_fatigue1.48304413
46MP0001984_abnormal_olfaction1.47916564
47MP0005584_abnormal_enzyme/coenzyme_acti1.47091925
48MP0002396_abnormal_hematopoietic_system1.46287048
49MP0009764_decreased_sensitivity_to1.44495184
50MP0003111_abnormal_nucleus_morphology1.41176445
51MP0002118_abnormal_lipid_homeostasis1.39270395
52MP0009046_muscle_twitch1.37767801
53MP0003191_abnormal_cellular_cholesterol1.37111761
54MP0001293_anophthalmia1.34765179
55MP0008058_abnormal_DNA_repair1.33674429
56MP0008789_abnormal_olfactory_epithelium1.32673798
57MP0000631_abnormal_neuroendocrine_gland1.31218314
58MP0003890_abnormal_embryonic-extraembry1.30903544
59MP0010094_abnormal_chromosome_stability1.30706661
60MP0003693_abnormal_embryo_hatching1.30461350
61MP0002638_abnormal_pupillary_reflex1.30315895
62MP0004142_abnormal_muscle_tone1.27775032
63MP0009643_abnormal_urine_homeostasis1.26657074
64MP0002234_abnormal_pharynx_morphology1.26592613
65MP0003121_genomic_imprinting1.25960842
66MP0002163_abnormal_gland_morphology1.25417559
67MP0005389_reproductive_system_phenotype1.21766158
68MP0008932_abnormal_embryonic_tissue1.20036410
69MP0001485_abnormal_pinna_reflex1.19624094
70MP0004885_abnormal_endolymph1.17335613
71MP0003937_abnormal_limbs/digits/tail_de1.16541845
72MP0005646_abnormal_pituitary_gland1.15703099
73MP0001929_abnormal_gametogenesis1.14940057
74MP0000598_abnormal_liver_morphology1.14880349
75MP0003880_abnormal_central_pattern1.13862285
76MP0002210_abnormal_sex_determination1.13094494
77MP0006035_abnormal_mitochondrial_morpho1.08725955
78MP0005647_abnormal_sex_gland1.08616102
79MP0009745_abnormal_behavioral_response1.08428292
80MP0003119_abnormal_digestive_system1.08201502
81MP0001968_abnormal_touch/_nociception1.05967671
82MP0002272_abnormal_nervous_system1.03879393
83MP0003698_abnormal_male_reproductive1.02551953
84MP0003718_maternal_effect1.02112168
85MP0000427_abnormal_hair_cycle1.01631115
86MP0008469_abnormal_protein_level1.00591687
87MP0004145_abnormal_muscle_electrophysio1.00179945
88MP0005379_endocrine/exocrine_gland_phen1.00177861
89MP0004043_abnormal_pH_regulation0.97627492
90MP0002751_abnormal_autonomic_nervous0.97413746
91MP0005174_abnormal_tail_pigmentation0.97371289
92MP0000653_abnormal_sex_gland0.97169974
93MP0002736_abnormal_nociception_after0.95627113
94MP0001188_hyperpigmentation0.94801344
95MP0008057_abnormal_DNA_replication0.93714616
96MP0001145_abnormal_male_reproductive0.92066221
97MP0005410_abnormal_fertilization0.90789351
98MP0003283_abnormal_digestive_organ0.90516934
99MP0001986_abnormal_taste_sensitivity0.88896086
100MP0005195_abnormal_posterior_eye0.87950435
101MP0005376_homeostasis/metabolism_phenot0.87218878
102MP0003077_abnormal_cell_cycle0.86440482
103MP0002095_abnormal_skin_pigmentation0.86244211
104MP0005075_abnormal_melanosome_morpholog0.85988503
105MP0009763_increased_sensitivity_to0.85821407
106MP0004742_abnormal_vestibular_system0.85809798
107MP0003122_maternal_imprinting0.85724880
108MP0001324_abnormal_eye_pigmentation0.85469335
109MP0003567_abnormal_fetal_cardiomyocyte0.85176014
110MP0003011_delayed_dark_adaptation0.84899745
111MP0005670_abnormal_white_adipose0.84690972
112MP0004957_abnormal_blastocyst_morpholog0.83655202
113MP0005499_abnormal_olfactory_system0.81979963
114MP0005394_taste/olfaction_phenotype0.81979963
115MP0001853_heart_inflammation0.80481338
116MP0000647_abnormal_sebaceous_gland0.79091687
117MP0000566_synostosis0.78963974
118MP0000490_abnormal_crypts_of0.78417307
119MP0001919_abnormal_reproductive_system0.77902577
120MP0002557_abnormal_social/conspecific_i0.76343626
121MP0005408_hypopigmentation0.74359168
122MP0008872_abnormal_physiological_respon0.73782531
123MP0005451_abnormal_body_composition0.72889125
124MP0009642_abnormal_blood_homeostasis0.71643608
125MP0005464_abnormal_platelet_physiology0.69889863
126MP0003724_increased_susceptibility_to0.69162106
127MP0005266_abnormal_metabolism0.68530283
128MP0008007_abnormal_cellular_replicative0.68159921
129MP0004215_abnormal_myocardial_fiber0.67528970
130MP0002254_reproductive_system_inflammat0.64380129
131MP0005220_abnormal_exocrine_pancreas0.60717912
132MP0003786_premature_aging0.60491006
133MP0008775_abnormal_heart_ventricle0.58150372
134MP0009765_abnormal_xenobiotic_induced0.57310952
135MP0008260_abnormal_autophagy0.57302667
136MP0002102_abnormal_ear_morphology0.56514394
137MP0002136_abnormal_kidney_physiology0.56474929
138MP0005395_other_phenotype0.52844801
139MP0000689_abnormal_spleen_morphology0.52650616
140MP0005377_hearing/vestibular/ear_phenot0.52506365
141MP0003878_abnormal_ear_physiology0.52506365
142MP0002876_abnormal_thyroid_physiology0.50309502
143MP0001661_extended_life_span0.49953639
144MP0006292_abnormal_olfactory_placode0.49773430
145MP0000604_amyloidosis0.49417479
146MP0009333_abnormal_splenocyte_physiolog0.47139654
147MP0001756_abnormal_urination0.46789367
148MP0002722_abnormal_immune_system0.46595457
149MP0005084_abnormal_gallbladder_morpholo0.45513684
150MP0002078_abnormal_glucose_homeostasis0.43258200
151MP0001915_intracranial_hemorrhage0.41124693
152MP0002429_abnormal_blood_cell0.40512568
153MP0000358_abnormal_cell_content/0.40312468
154MP0002398_abnormal_bone_marrow0.40208123
155MP0005334_abnormal_fat_pad0.39787797
156MP0009931_abnormal_skin_appearance0.38516271
157MP0001119_abnormal_female_reproductive0.37288075
158MP0000313_abnormal_cell_death0.36307890
159MP0008873_increased_physiological_sensi0.34832736
160MP0002938_white_spotting0.32772573
161MP0002019_abnormal_tumor_incidence0.32367095
162MP0002970_abnormal_white_adipose0.32290602
163MP0009053_abnormal_anal_canal0.32116209
164MP0003638_abnormal_response/metabolism_0.31485700

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)9.07273696
2Poikilocytosis (HP:0004447)5.31781548
3Intrahepatic cholestasis (HP:0001406)5.10092700
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.06764499
5Acanthocytosis (HP:0001927)5.05257200
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.71724986
7Hyperbilirubinemia (HP:0002904)4.67384871
8Prolonged partial thromboplastin time (HP:0003645)4.50916494
9Hypobetalipoproteinemia (HP:0003563)4.43140499
10Reticulocytosis (HP:0001923)4.35463591
11Deep venous thrombosis (HP:0002625)4.19609988
12Abnormal number of erythroid precursors (HP:0012131)3.97946144
13Pancreatic cysts (HP:0001737)3.91113507
14Xanthomatosis (HP:0000991)3.90600731
15Hyperammonemia (HP:0001987)3.90600328
16Pancreatic fibrosis (HP:0100732)3.81486243
17Abnormality of pyrimidine metabolism (HP:0004353)3.78690072
18Hyperlipoproteinemia (HP:0010980)3.66397914
19Hyperglycinemia (HP:0002154)3.56164484
20Molar tooth sign on MRI (HP:0002419)3.52240688
21Abnormality of midbrain morphology (HP:0002418)3.52240688
22Abnormality of cells of the erythroid lineage (HP:0012130)3.49223352
23True hermaphroditism (HP:0010459)3.46713249
24Abnormality of reticulocytes (HP:0004312)3.32904304
25Nephronophthisis (HP:0000090)3.29803806
26Hyperglycinuria (HP:0003108)3.28639402
27Hypolipoproteinemia (HP:0010981)3.28032360
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.26714078
29Abnormality of methionine metabolism (HP:0010901)3.26424035
30Joint hemorrhage (HP:0005261)3.25631037
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.23475786
32Abnormality of serine family amino acid metabolism (HP:0010894)3.21596414
33Abnormality of glycine metabolism (HP:0010895)3.21596414
34Ketosis (HP:0001946)3.19156741
35Acute necrotizing encephalopathy (HP:0006965)3.18518032
36Cholelithiasis (HP:0001081)3.05304918
37Abnormality of glutamine family amino acid metabolism (HP:0010902)3.03796748
38Increased serum ferritin (HP:0003281)3.02171034
39Hypochromic microcytic anemia (HP:0004840)3.00759480
40Abnormality of serum amino acid levels (HP:0003112)2.97669409
41Medial flaring of the eyebrow (HP:0010747)2.97553671
42Increased CSF lactate (HP:0002490)2.96216087
43Birth length less than 3rd percentile (HP:0003561)2.96189264
44Abnormality of iron homeostasis (HP:0011031)2.95248422
45Hepatocellular carcinoma (HP:0001402)2.94092407
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.91546908
47Abnormality of transition element cation homeostasis (HP:0011030)2.90669206
48Mitochondrial inheritance (HP:0001427)2.89597418
49Abnormal gallbladder morphology (HP:0012437)2.88966851
50Delayed CNS myelination (HP:0002188)2.85140859
51Type II lissencephaly (HP:0007260)2.83264326
52Complement deficiency (HP:0004431)2.79704185
53Abnormality of fatty-acid metabolism (HP:0004359)2.79219522
54Abnormality of nucleobase metabolism (HP:0010932)2.79199323
55Progressive macrocephaly (HP:0004481)2.79066361
56Metabolic acidosis (HP:0001942)2.78530401
57Abnormality of the renal medulla (HP:0100957)2.77710398
58Hypoalphalipoproteinemia (HP:0003233)2.76297980
59Brushfield spots (HP:0001088)2.74776777
60Nausea (HP:0002018)2.74126083
61Abnormal mitochondria in muscle tissue (HP:0008316)2.74102009
62Fat malabsorption (HP:0002630)2.73487227
63Colon cancer (HP:0003003)2.72645360
64Abnormality of the labia minora (HP:0012880)2.71715574
65Abnormality of the renal cortex (HP:0011035)2.70155133
66Hypoglycemic coma (HP:0001325)2.67953543
67Abnormal gallbladder physiology (HP:0012438)2.65088223
68Cholecystitis (HP:0001082)2.65088223
69Congenital stationary night blindness (HP:0007642)2.64024790
70Dicarboxylic aciduria (HP:0003215)2.61164163
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.61164163
72Abnormality of the common coagulation pathway (HP:0010990)2.60633691
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.59603372
74Lethargy (HP:0001254)2.57308657
75Conjugated hyperbilirubinemia (HP:0002908)2.55625782
76Increased hepatocellular lipid droplets (HP:0006565)2.55308115
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.52225841
78Diaphragmatic weakness (HP:0009113)2.50471159
79Cerebral edema (HP:0002181)2.48947007
80Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47632021
81Abnormality of the intrinsic pathway (HP:0010989)2.47259813
82Lipid accumulation in hepatocytes (HP:0006561)2.47029542
83Polycythemia (HP:0001901)2.45153572
84Cystic liver disease (HP:0006706)2.44423837
85Pendular nystagmus (HP:0012043)2.42639177
86Ketoacidosis (HP:0001993)2.38978318
87Chromsome breakage (HP:0040012)2.38738158
88Epidermoid cyst (HP:0200040)2.36164873
89Chronic hepatic failure (HP:0100626)2.35173758
90Congenital primary aphakia (HP:0007707)2.31160750
91Abnormality of purine metabolism (HP:0004352)2.29453949
92Gait imbalance (HP:0002141)2.28391904
93Sclerocornea (HP:0000647)2.27673131
94Hypercholesterolemia (HP:0003124)2.27287852
95Abnormality of the gallbladder (HP:0005264)2.27035239
96Methylmalonic acidemia (HP:0002912)2.26635620
97Generalized aminoaciduria (HP:0002909)2.25205991
983-Methylglutaconic aciduria (HP:0003535)2.25160000
99Steatorrhea (HP:0002570)2.24412373
100Vomiting (HP:0002013)2.24054616
101Meckel diverticulum (HP:0002245)2.22828159
102Abnormality of the ileum (HP:0001549)2.22609442
103Prolonged bleeding time (HP:0003010)2.22511860
104Reticulocytopenia (HP:0001896)2.20485559
105Nephrogenic diabetes insipidus (HP:0009806)2.19946477
106Opisthotonus (HP:0002179)2.19515032
107Reduced antithrombin III activity (HP:0001976)2.18604007
108Epistaxis (HP:0000421)2.17703709
109Anencephaly (HP:0002323)2.15237304
110Proximal tubulopathy (HP:0000114)2.14646659
111Microcytic anemia (HP:0001935)2.13645388
112Hepatic necrosis (HP:0002605)2.12861162
113Oral leukoplakia (HP:0002745)2.11707808
114Aplasia/Hypoplasia of the tongue (HP:0010295)2.11672886
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11670138
116Abnormality of alanine metabolism (HP:0010916)2.11670138
117Hyperalaninemia (HP:0003348)2.11670138
118Petechiae (HP:0000967)2.07149243
119Abolished electroretinogram (ERG) (HP:0000550)2.06598027
120Optic disc pallor (HP:0000543)2.05404758
121Hypoplasia of the pons (HP:0012110)2.05115919
122Abnormality of the pons (HP:0007361)2.04962519
123Cerebellar dysplasia (HP:0007033)2.04019566
124Sloping forehead (HP:0000340)2.03708162
125Gout (HP:0001997)2.01798494
126Abnormality of complement system (HP:0005339)2.01107708
127Increased serum lactate (HP:0002151)2.00237247
128Tubular atrophy (HP:0000092)1.99443375
129Abnormality of urine glucose concentration (HP:0011016)1.99296822
130Glycosuria (HP:0003076)1.99296822
131Abnormal biliary tract physiology (HP:0012439)1.99211972
132Bile duct proliferation (HP:0001408)1.99211972
133Attenuation of retinal blood vessels (HP:0007843)1.99010720
134Spastic diplegia (HP:0001264)1.98819653
135Cerebral palsy (HP:0100021)1.97816043
136Paralysis (HP:0003470)1.97194821
137Abnormality of chromosome stability (HP:0003220)1.97115665
138Acute encephalopathy (HP:0006846)1.96961425
139Postaxial foot polydactyly (HP:0001830)1.96763102
140Absent thumb (HP:0009777)1.96140780
141Ileus (HP:0002595)1.95707543
142Osteomalacia (HP:0002749)1.94587073
143Genital tract atresia (HP:0001827)1.93086245
144Furrowed tongue (HP:0000221)1.92394861
145Renal Fanconi syndrome (HP:0001994)1.92305436
146Lactic acidosis (HP:0003128)1.90720994
147Lissencephaly (HP:0001339)1.89439165
148Methylmalonic aciduria (HP:0012120)1.88635278
149Abnormal rod and cone electroretinograms (HP:0008323)1.87954167
150Confusion (HP:0001289)1.87772648
151Elevated hepatic transaminases (HP:0002910)1.87700901
152Renal cortical cysts (HP:0000803)1.87038094
153Congenital hepatic fibrosis (HP:0002612)1.86832598
154Duplicated collecting system (HP:0000081)1.86428907
155Vaginal atresia (HP:0000148)1.85235705
156Aplastic anemia (HP:0001915)1.83861037
157Abnormality of the renal collecting system (HP:0004742)1.82455481
158Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81692012
159Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81692012
160Abnormality of the preputium (HP:0100587)1.80735109
161Hepatocellular necrosis (HP:0001404)1.80196181
162Abnormal protein N-linked glycosylation (HP:0012347)1.77957002
163Abnormal protein glycosylation (HP:0012346)1.77957002
164Abnormal glycosylation (HP:0012345)1.77957002
165Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77957002
166Dandy-Walker malformation (HP:0001305)1.77513246
167Congenital, generalized hypertrichosis (HP:0004540)1.76418523
168Aplasia/Hypoplasia of the spleen (HP:0010451)1.76137646
169Poor coordination (HP:0002370)1.75642838
170Hypothermia (HP:0002045)1.75104123
171Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74704185
172Triphalangeal thumb (HP:0001199)1.74597639
173Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74346962
174Large for gestational age (HP:0001520)1.74338745
175Male pseudohermaphroditism (HP:0000037)1.73376574
176Dynein arm defect of respiratory motile cilia (HP:0012255)1.72983728
177Absent/shortened dynein arms (HP:0200106)1.72983728
178Abnormal drinking behavior (HP:0030082)1.72923171
179Polydipsia (HP:0001959)1.72923171
180Aplasia/Hypoplasia of the tibia (HP:0005772)1.71697769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.66117692
2BCKDK4.10894392
3FRK3.80266401
4BMPR1B3.60339686
5NME23.53079446
6STK162.87041163
7WNK32.85140473
8VRK22.58858383
9SIK12.53849912
10NUAK12.49387371
11CDC72.42339981
12VRK12.41761362
13ACVR1B2.33007869
14ZAK2.19707312
15MAP4K22.14662522
16WNK42.08126545
17WEE12.06702222
18ADRBK22.00492465
19BUB11.94558844
20DYRK31.93739362
21TRIM281.85563228
22TLK11.85471045
23SRPK11.83949949
24CDK81.83789969
25KDR1.81613513
26PLK31.79540487
27BRSK21.78933966
28PIM21.74581967
29FLT31.74235255
30MKNK21.66185994
31MST41.59526219
32MAPK111.57889923
33NEK11.54253091
34MAP3K41.48446521
35NEK21.44663315
36ABL21.43626703
37TSSK61.43421722
38TYK21.41111642
39TAOK31.32421442
40PASK1.31236024
41EIF2AK31.30448511
42MAP3K111.27357755
43SIK31.27197286
44DYRK21.24349390
45MAPK131.23591987
46BRSK11.22528716
47TTK1.18571579
48ATR1.17838033
49PINK11.16067149
50STK41.15006751
51RPS6KA41.12909288
52IRAK31.12690704
53TAF11.12652016
54PBK1.11584366
55CDK41.11149514
56PLK41.07853852
57OXSR11.07072725
58MAPKAPK51.05212885
59STK391.02348126
60PNCK0.98738635
61PLK10.97775988
62AURKB0.96429557
63FGFR40.95960984
64PLK20.92865407
65JAK20.90569675
66CASK0.90013570
67KIT0.87908165
68EIF2AK20.87740336
69CDK70.87309480
70STK30.84341166
71STK100.81178923
72CDK190.80739693
73PIM10.79475349
74TBK10.79415018
75ERBB20.78503891
76MAP2K30.77107668
77INSRR0.76255286
78STK38L0.76132261
79MAP4K10.73877065
80CHEK20.73484961
81TGFBR20.72177607
82RPS6KA50.71820128
83PIK3CG0.71697753
84AURKA0.71522100
85ERBB30.71392430
86MAPK120.70854772
87CSNK1G10.69226434
88PDK20.68513024
89CAMKK20.67941891
90CSNK2A10.67398811
91PRKCG0.66794612
92TNIK0.66102724
93TAOK20.65511440
94TEC0.65442648
95IKBKB0.63725259
96PAK30.63381735
97CSNK1G20.63300132
98BCR0.63258387
99CCNB10.62718114
100CSNK1G30.62582671
101BLK0.61886496
102MAP3K100.61283515
103FGFR20.60468837
104MAP2K70.60441681
105MAPKAPK30.59117944
106PRKCI0.57417024
107MUSK0.55433347
108GRK10.55107392
109NEK90.54844326
110PRKCE0.54560299
111TGFBR10.54454426
112ATM0.54331838
113LYN0.54017631
114MAP2K40.51996721
115CSNK2A20.51881103
116MAP3K80.51862879
117BRAF0.51451543
118LIMK10.51159416
119IRAK10.50993390
120CSNK1A1L0.50948504
121ADRBK10.50933706
122MKNK10.50432223
123MAPK40.50401854
124CDK60.49323996
125JAK30.48422046
126CAMK1D0.48216462
127SCYL20.48102486
128NME10.47888569
129ERBB40.46631507
130ERN10.46297450
131NLK0.42026459
132DAPK20.41007051
133CHEK10.40404040
134TXK0.40207247
135MST1R0.39994529
136PHKG20.39626470
137PHKG10.39626470
138PRKAA20.39063775
139CSF1R0.36876405
140NTRK30.36283493
141TIE10.35741917
142GRK60.35675207
143IKBKE0.34316654
144AKT20.34171547
145PRKACG0.33961617
146MAP3K140.33613254
147AKT30.33329855
148CSNK1A10.32647618
149CSNK1E0.30871856
150PRKACA0.29839284

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.33216270
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.28791001
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.75087097
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34162371
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.31564760
6Fatty acid degradation_Homo sapiens_hsa000712.15472841
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14027650
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13235925
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.12848633
10Peroxisome_Homo sapiens_hsa041462.11180185
11Arginine biosynthesis_Homo sapiens_hsa002202.09389398
12Nitrogen metabolism_Homo sapiens_hsa009102.08840645
13Tryptophan metabolism_Homo sapiens_hsa003802.05413346
14DNA replication_Homo sapiens_hsa030302.02780759
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.98539295
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97895467
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97885057
18One carbon pool by folate_Homo sapiens_hsa006701.93785903
19Complement and coagulation cascades_Homo sapiens_hsa046101.90170587
20Phototransduction_Homo sapiens_hsa047441.87770162
21Folate biosynthesis_Homo sapiens_hsa007901.86768915
22Sulfur relay system_Homo sapiens_hsa041221.82974199
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.82372653
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.81123900
25Propanoate metabolism_Homo sapiens_hsa006401.79297613
26Caffeine metabolism_Homo sapiens_hsa002321.78754460
27Selenocompound metabolism_Homo sapiens_hsa004501.76846077
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72469744
29beta-Alanine metabolism_Homo sapiens_hsa004101.69965530
30Chemical carcinogenesis_Homo sapiens_hsa052041.65689218
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.62251453
32Butanoate metabolism_Homo sapiens_hsa006501.61600434
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58467989
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53487683
35Fatty acid metabolism_Homo sapiens_hsa012121.50889260
36Retinol metabolism_Homo sapiens_hsa008301.44785398
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44771471
38Alzheimers disease_Homo sapiens_hsa050101.44220038
39Histidine metabolism_Homo sapiens_hsa003401.41328822
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40273145
41Pyruvate metabolism_Homo sapiens_hsa006201.38158471
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38026634
43PPAR signaling pathway_Homo sapiens_hsa033201.36063200
44Vitamin B6 metabolism_Homo sapiens_hsa007501.32785692
45Pyrimidine metabolism_Homo sapiens_hsa002401.31957501
46Biosynthesis of amino acids_Homo sapiens_hsa012301.24580617
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24530900
48ABC transporters_Homo sapiens_hsa020101.24345025
49Carbon metabolism_Homo sapiens_hsa012001.16928323
50Sulfur metabolism_Homo sapiens_hsa009201.11604010
51Pentose phosphate pathway_Homo sapiens_hsa000301.11131220
52Mismatch repair_Homo sapiens_hsa034301.10297634
53Phenylalanine metabolism_Homo sapiens_hsa003601.10013152
54Arginine and proline metabolism_Homo sapiens_hsa003301.09302967
55Glutathione metabolism_Homo sapiens_hsa004801.08599190
56Cardiac muscle contraction_Homo sapiens_hsa042601.06920723
57Proteasome_Homo sapiens_hsa030501.05958576
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.05778390
59Fatty acid elongation_Homo sapiens_hsa000621.03827161
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03713372
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02418576
62Vitamin digestion and absorption_Homo sapiens_hsa049771.02019949
63Staphylococcus aureus infection_Homo sapiens_hsa051501.00779899
64Nicotine addiction_Homo sapiens_hsa050330.99894346
65Bile secretion_Homo sapiens_hsa049760.99817633
66Ribosome_Homo sapiens_hsa030100.99722328
67Starch and sucrose metabolism_Homo sapiens_hsa005000.99131364
68Tyrosine metabolism_Homo sapiens_hsa003500.98053750
69Base excision repair_Homo sapiens_hsa034100.92657823
70Homologous recombination_Homo sapiens_hsa034400.92500102
71Ether lipid metabolism_Homo sapiens_hsa005650.86354446
72RNA polymerase_Homo sapiens_hsa030200.86313021
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85611964
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82418175
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81513177
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79635807
77Metabolic pathways_Homo sapiens_hsa011000.78833801
78Fat digestion and absorption_Homo sapiens_hsa049750.76715660
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76443300
80Nucleotide excision repair_Homo sapiens_hsa034200.76227288
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74990849
82Olfactory transduction_Homo sapiens_hsa047400.74101491
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72190259
84Systemic lupus erythematosus_Homo sapiens_hsa053220.68746040
85Steroid biosynthesis_Homo sapiens_hsa001000.68249866
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64540517
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.62191048
88Taste transduction_Homo sapiens_hsa047420.59606873
89Regulation of autophagy_Homo sapiens_hsa041400.58676782
90Fanconi anemia pathway_Homo sapiens_hsa034600.57523234
91Fatty acid biosynthesis_Homo sapiens_hsa000610.56876836
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56185596
93Purine metabolism_Homo sapiens_hsa002300.55853456
94Lysine degradation_Homo sapiens_hsa003100.54850584
95Collecting duct acid secretion_Homo sapiens_hsa049660.54036577
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52741448
97Non-homologous end-joining_Homo sapiens_hsa034500.52081302
98Spliceosome_Homo sapiens_hsa030400.51608185
99Arachidonic acid metabolism_Homo sapiens_hsa005900.49379750
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48785977
101Parkinsons disease_Homo sapiens_hsa050120.47992896
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44020954
103mRNA surveillance pathway_Homo sapiens_hsa030150.42969596
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41422883
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41076597
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41039360
107Cell cycle_Homo sapiens_hsa041100.39848406
108Oocyte meiosis_Homo sapiens_hsa041140.39392372
109Oxidative phosphorylation_Homo sapiens_hsa001900.39264436
110Linoleic acid metabolism_Homo sapiens_hsa005910.39015162
111RNA transport_Homo sapiens_hsa030130.34194246
112Glycerolipid metabolism_Homo sapiens_hsa005610.30815296
113Huntingtons disease_Homo sapiens_hsa050160.26623543
114Fructose and mannose metabolism_Homo sapiens_hsa000510.23209426
115Basal transcription factors_Homo sapiens_hsa030220.22248881
116Galactose metabolism_Homo sapiens_hsa000520.21610785
117RNA degradation_Homo sapiens_hsa030180.20338770
118Protein export_Homo sapiens_hsa030600.18689895
119p53 signaling pathway_Homo sapiens_hsa041150.18145552
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14544598

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