SLC25A22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.57575543
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.57575543
3sodium ion export (GO:0071436)5.46702149
4positive regulation of synapse maturation (GO:0090129)5.41955202
5L-phenylalanine metabolic process (GO:0006558)5.35141940
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.35141940
7cellular potassium ion homeostasis (GO:0030007)5.16987595
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.03066737
9regulation of synaptic vesicle transport (GO:1902803)4.94261360
10aromatic amino acid family catabolic process (GO:0009074)4.88399809
11regulation of neuronal synaptic plasticity (GO:0048168)4.73962979
12kynurenine metabolic process (GO:0070189)4.53904240
13alpha-linolenic acid metabolic process (GO:0036109)4.51997170
14synaptic vesicle endocytosis (GO:0048488)4.50624080
15bile acid biosynthetic process (GO:0006699)4.49583607
16urea metabolic process (GO:0019627)4.43470330
17urea cycle (GO:0000050)4.43470330
18neuronal ion channel clustering (GO:0045161)4.37001079
19high-density lipoprotein particle remodeling (GO:0034375)4.35028036
20layer formation in cerebral cortex (GO:0021819)4.33173120
21indole-containing compound catabolic process (GO:0042436)4.31130609
22indolalkylamine catabolic process (GO:0046218)4.31130609
23tryptophan catabolic process (GO:0006569)4.31130609
24cerebellar granule cell differentiation (GO:0021707)4.23148606
25amino acid import (GO:0043090)4.16525003
26exploration behavior (GO:0035640)4.14206621
27dicarboxylic acid biosynthetic process (GO:0043650)4.12467986
28negative regulation of fibrinolysis (GO:0051918)4.07153001
29regulation of long-term neuronal synaptic plasticity (GO:0048169)4.06905481
30regulation of synapse structural plasticity (GO:0051823)4.06876923
31neurotransmitter transport (GO:0006836)4.06230814
32glyoxylate metabolic process (GO:0046487)4.03181302
33nitrogen cycle metabolic process (GO:0071941)4.02754346
34tryptophan metabolic process (GO:0006568)3.99609262
35regulation of ARF protein signal transduction (GO:0032012)3.99577461
36cell migration in hindbrain (GO:0021535)3.93422277
37regulation of synapse maturation (GO:0090128)3.92022436
38cellular ketone body metabolic process (GO:0046950)3.91608612
39glutamate metabolic process (GO:0006536)3.91416126
40complement activation, alternative pathway (GO:0006957)3.89576684
41ionotropic glutamate receptor signaling pathway (GO:0035235)3.89361051
42regulation of protein activation cascade (GO:2000257)3.86513139
43L-amino acid import (GO:0043092)3.84999175
44protein localization to synapse (GO:0035418)3.83940908
45sulfur amino acid catabolic process (GO:0000098)3.83850369
46regulation of fibrinolysis (GO:0051917)3.83627119
47regulation of synaptic plasticity (GO:0048167)3.83313874
48bile acid metabolic process (GO:0008206)3.83285148
49cysteine metabolic process (GO:0006534)3.82257459
50peptidyl-glutamic acid carboxylation (GO:0017187)3.82091128
51protein carboxylation (GO:0018214)3.82091128
52lysine catabolic process (GO:0006554)3.81019268
53lysine metabolic process (GO:0006553)3.81019268
54establishment of mitochondrion localization (GO:0051654)3.80655541
55cytoskeletal anchoring at plasma membrane (GO:0007016)3.79689541
56reverse cholesterol transport (GO:0043691)3.78978066
57regulation of cholesterol esterification (GO:0010872)3.75826444
58dendritic spine organization (GO:0097061)3.75484535
59neuromuscular process controlling balance (GO:0050885)3.73602415
60regulation of triglyceride catabolic process (GO:0010896)3.73134512
61positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.73017230
62macromolecular complex remodeling (GO:0034367)3.70592343
63plasma lipoprotein particle remodeling (GO:0034369)3.70592343
64protein-lipid complex remodeling (GO:0034368)3.70592343
65positive regulation of membrane potential (GO:0045838)3.70480343
66serine family amino acid catabolic process (GO:0009071)3.69236857
67synaptic vesicle maturation (GO:0016188)3.69034767
68positive regulation of dendritic spine development (GO:0060999)3.68966427
69protein retention in ER lumen (GO:0006621)3.67907210
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66455966
71regulation of neurotransmitter levels (GO:0001505)3.64672609
72negative regulation of cholesterol transport (GO:0032375)3.64137394
73negative regulation of sterol transport (GO:0032372)3.64137394
74regulation of short-term neuronal synaptic plasticity (GO:0048172)3.59828172
75postsynaptic membrane organization (GO:0001941)3.58750889
76regulation of complement activation (GO:0030449)3.57491804
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.56429176
78negative regulation of synaptic transmission, GABAergic (GO:0032229)3.56426302
79regulation of glutamate receptor signaling pathway (GO:1900449)3.55452808
80mitochondrion transport along microtubule (GO:0047497)3.55320282
81establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.55320282
82fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.54193833
83phospholipid efflux (GO:0033700)3.54188452
84triglyceride homeostasis (GO:0070328)3.54153626
85acylglycerol homeostasis (GO:0055090)3.54153626
86alpha-amino acid catabolic process (GO:1901606)3.52769903
87positive regulation of dendritic spine morphogenesis (GO:0061003)3.50564395
88synaptic transmission, glutamatergic (GO:0035249)3.50017213
89pyrimidine nucleobase catabolic process (GO:0006208)3.46654815
90locomotory exploration behavior (GO:0035641)3.46475177
91aromatic amino acid family metabolic process (GO:0009072)3.46243399
92dendritic spine morphogenesis (GO:0060997)3.44188955
93positive regulation of neurotransmitter transport (GO:0051590)3.43211158
94coenzyme catabolic process (GO:0009109)3.41342052
95glutamate secretion (GO:0014047)3.39721668
96regulation of vesicle fusion (GO:0031338)3.38981539
97homocysteine metabolic process (GO:0050667)3.37431274
98tyrosine metabolic process (GO:0006570)3.37187873
99regulation of cholesterol homeostasis (GO:2000188)3.36533490
100cholesterol efflux (GO:0033344)3.34989307
101ketone body metabolic process (GO:1902224)3.34697663
102regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34669986
103amino-acid betaine metabolic process (GO:0006577)3.33195735
104drug catabolic process (GO:0042737)3.33038977
105potassium ion homeostasis (GO:0055075)3.32865888
106regulation of neurotransmitter secretion (GO:0046928)3.32145447
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31968138
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31699025
109maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.31235273
110cellular modified amino acid catabolic process (GO:0042219)3.29785215
111plasma lipoprotein particle clearance (GO:0034381)3.28962470
112cellular amino acid catabolic process (GO:0009063)3.28496392
113positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.26241783
114positive regulation of neurotransmitter secretion (GO:0001956)3.26207879
115cell communication by electrical coupling (GO:0010644)3.26024490
116gamma-aminobutyric acid transport (GO:0015812)3.24610190
117neuron cell-cell adhesion (GO:0007158)3.22270091
118positive regulation of lipid catabolic process (GO:0050996)3.21737658
119nucleobase catabolic process (GO:0046113)3.18955606
120positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.18564780
121cerebellar Purkinje cell layer development (GO:0021680)3.17828537
122long-term memory (GO:0007616)3.16172064
123neuronal action potential propagation (GO:0019227)3.12926997
124arginine metabolic process (GO:0006525)3.11441072
125bile acid and bile salt transport (GO:0015721)3.08677390
126regulation of postsynaptic membrane potential (GO:0060078)3.08609262
127regulation of dendritic spine morphogenesis (GO:0061001)3.06373337
128aspartate family amino acid catabolic process (GO:0009068)3.05065375
129dicarboxylic acid catabolic process (GO:0043649)3.04348744
130synaptic vesicle docking involved in exocytosis (GO:0016081)3.03952385
131vocalization behavior (GO:0071625)3.03775728
132synaptic vesicle transport (GO:0048489)3.03293230
133establishment of synaptic vesicle localization (GO:0097480)3.03293230
134central nervous system myelination (GO:0022010)3.03291933
135axon ensheathment in central nervous system (GO:0032291)3.03291933
136neurotransmitter-gated ion channel clustering (GO:0072578)3.03084678
1372-oxoglutarate metabolic process (GO:0006103)3.01843642
138exogenous drug catabolic process (GO:0042738)3.01266155
139regulation of bile acid biosynthetic process (GO:0070857)3.01081164
140negative regulation of dendrite morphogenesis (GO:0050774)3.00876597
141regulation of voltage-gated calcium channel activity (GO:1901385)3.00109250
142* dicarboxylic acid transport (GO:0006835)2.98650964
143synaptic vesicle exocytosis (GO:0016079)2.98425191
144neuron-neuron synaptic transmission (GO:0007270)2.97772211
145proline biosynthetic process (GO:0006561)2.96449252
146neurotransmitter secretion (GO:0007269)2.96309628
147plasma lipoprotein particle assembly (GO:0034377)2.96059382
148indolalkylamine metabolic process (GO:0006586)2.95729610
149negative regulation of microtubule polymerization (GO:0031115)2.93119105
150low-density lipoprotein particle remodeling (GO:0034374)2.92996155
151phospholipid homeostasis (GO:0055091)2.91594751
152regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90430646
153benzene-containing compound metabolic process (GO:0042537)2.89725411
154negative regulation of lipase activity (GO:0060192)2.89001138
155acetyl-CoA metabolic process (GO:0006084)2.87922830
156imidazole-containing compound metabolic process (GO:0052803)2.87698369
157regulation of neurotransmitter transport (GO:0051588)2.86137941
158mating behavior (GO:0007617)2.85398341
159glutamate receptor signaling pathway (GO:0007215)2.85147463
160neuromuscular process controlling posture (GO:0050884)2.84945998
161regulation of synaptic transmission (GO:0050804)2.83820324
162alanine transport (GO:0032328)2.82557499
163regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.79894399
164cytolysis (GO:0019835)2.79599260
165vesicle docking involved in exocytosis (GO:0006904)2.78852487
166short-chain fatty acid metabolic process (GO:0046459)2.78417453
167cerebellar Purkinje cell differentiation (GO:0021702)2.78372508
168organic acid catabolic process (GO:0016054)2.77374473
169carboxylic acid catabolic process (GO:0046395)2.77374473
170regulation of ARF GTPase activity (GO:0032312)2.76698566
171positive regulation of fatty acid biosynthetic process (GO:0045723)2.75711424
172activation of protein kinase A activity (GO:0034199)2.75378701
173regulation of synaptic vesicle exocytosis (GO:2000300)2.74973021
174glycine metabolic process (GO:0006544)2.74867571
175positive regulation of fatty acid beta-oxidation (GO:0032000)2.74684246
176ethanol oxidation (GO:0006069)2.73556823
177auditory behavior (GO:0031223)2.72177509
178positive regulation of dendrite development (GO:1900006)2.72003024
179regulation of dendrite morphogenesis (GO:0048814)2.70091357
180mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.69950667
181peptidyl-tyrosine autophosphorylation (GO:0038083)2.69935334
182activation of Rac GTPase activity (GO:0032863)2.65716473
183neuromuscular synaptic transmission (GO:0007274)2.65710274
184neuromuscular process (GO:0050905)2.65086403
185regulation of dendritic spine development (GO:0060998)2.65017767
186potassium ion import (GO:0010107)2.64410594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.23015632
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.10085177
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.24732756
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.94556368
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.61197820
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.23182946
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.19114959
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.13013207
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.93360104
10EZH2_22144423_ChIP-Seq_EOC_Human2.83055799
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.36190564
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.15863202
13* P68_20966046_ChIP-Seq_HELA_Human2.14538981
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13899711
15SRY_22984422_ChIP-ChIP_TESTIS_Rat2.05476386
16TET1_21451524_ChIP-Seq_MESCs_Mouse2.02205233
17REST_21632747_ChIP-Seq_MESCs_Mouse2.00484175
18DROSHA_22980978_ChIP-Seq_HELA_Human1.98632466
19* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95050579
20RARB_27405468_Chip-Seq_BRAIN_Mouse1.94950613
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88600092
22RACK7_27058665_Chip-Seq_MCF-7_Human1.87739791
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87614141
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.86084148
25* KDM2B_26808549_Chip-Seq_DND41_Human1.85467412
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80473452
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79750358
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79278276
29* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78216905
30VDR_21846776_ChIP-Seq_THP-1_Human1.78203946
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77585351
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.75640843
33* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72845482
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72472498
35* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.70849978
36* ELK3_25401928_ChIP-Seq_HUVEC_Human1.68827772
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.66751739
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62333232
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62333232
40* SA1_27219007_Chip-Seq_ERYTHROID_Human1.61050697
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.60324344
42SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.59637913
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59378389
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.54383666
45* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54323305
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53619935
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53223708
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51076320
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51024189
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.50548465
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.48799049
52* MYC_22102868_ChIP-Seq_BL_Human1.48311921
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47770793
54GBX2_23144817_ChIP-Seq_PC3_Human1.46588188
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45136926
56TCF7_22412390_ChIP-Seq_EML_Mouse1.43419411
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42606063
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40601244
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.37393489
60* KDM2B_26808549_Chip-Seq_JURKAT_Human1.37273132
61FOXA2_19822575_ChIP-Seq_HepG2_Human1.36834216
62* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36578402
63* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36065535
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34237103
65* LXR_22292898_ChIP-Seq_THP-1_Human1.34191126
66OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.31760084
67SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.31511366
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29673623
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29345280
70* BCOR_27268052_Chip-Seq_Bcells_Human1.24116271
71PHF8_20622854_ChIP-Seq_HELA_Human1.23932512
72RARA_24833708_ChIP-Seq_LIVER_Mouse1.23754546
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22987378
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22468372
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22416322
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20012500
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19939277
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19724554
79SA1_27219007_Chip-Seq_Bcells_Human1.19233874
80* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18681118
81OCT4_19829295_ChIP-Seq_ESCs_Human1.17824686
82CTCF_20526341_ChIP-Seq_ESCs_Human1.17471309
83* FOXP1_21924763_ChIP-Seq_HESCs_Human1.14689872
84KDM2B_26808549_Chip-Seq_K562_Human1.13834612
85P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13778779
86* BCL6_27268052_Chip-Seq_Bcells_Human1.12520432
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12089555
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11856140
89* TP53_22127205_ChIP-Seq_IMR90_Human1.11712495
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.10914714
91JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.10150347
92EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09945346
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09040750
94RARB_24833708_ChIP-Seq_LIVER_Mouse1.08146349
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.08046762
96* E2F1_20622854_ChIP-Seq_HELA_Human1.06978096
97EZH2_27304074_Chip-Seq_ESCs_Mouse1.06959560
98XRN2_22483619_ChIP-Seq_HELA_Human1.05083463
99* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02787975
100* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02578127
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02526161
102* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02108956
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01838137
104* CTCF_27219007_Chip-Seq_Bcells_Human1.01581773
105HTT_18923047_ChIP-ChIP_STHdh_Human1.01580996
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99035661
107AR_21572438_ChIP-Seq_LNCaP_Human0.98821181
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98668324
109GATA1_22025678_ChIP-Seq_K562_Human0.97919911
110ZNF263_19887448_ChIP-Seq_K562_Human0.97844907
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96673786
112HNF4A_19822575_ChIP-Seq_HepG2_Human0.94853326
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92583080
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.90447447
115NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86650105
116SOX2_21211035_ChIP-Seq_LN229_Gbm0.85976585
117SMC4_20622854_ChIP-Seq_HELA_Human0.85895980
118AR_19668381_ChIP-Seq_PC3_Human0.85534008
119* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82751627
120KLF4_19829295_ChIP-Seq_ESCs_Human0.82002484
121TET1_21490601_ChIP-Seq_MESCs_Mouse0.80770909
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79342140
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78660373
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.78347447
125RING1B_27294783_Chip-Seq_ESCs_Mouse0.78105437
126* CREB1_26743006_Chip-Seq_LNCaP_Human0.77954512
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77462037
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.74993106
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74864661
130SMAD4_21799915_ChIP-Seq_A2780_Human0.72415427
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.72361551
132CLOCK_20551151_ChIP-Seq_293T_Human0.71917670
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68989611
134CTBP2_25329375_ChIP-Seq_LNCAP_Human0.68683324
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.68105282
136RXRA_24833708_ChIP-Seq_LIVER_Mouse0.67076253
137EGR1_19032775_ChIP-ChIP_M12_Human0.67059814
138WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.66769375
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.65858515
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65524302
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.64503438
142AR_25329375_ChIP-Seq_VCAP_Human0.64335925
143NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63676936
144TAF15_26573619_Chip-Seq_HEK293_Human0.63042553
145* MYC_27129775_Chip-Seq_CORNEA_Mouse0.62455682
146* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.62226591
147HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.61489083
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.61466606
149GATA1_19941826_ChIP-Seq_K562_Human0.61389163

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.10799360
2MP0005360_urolithiasis5.83231436
3MP0005085_abnormal_gallbladder_physiolo4.88010090
4MP0005365_abnormal_bile_salt4.68828647
5MP0004859_abnormal_synaptic_plasticity4.22329158
6MP0008875_abnormal_xenobiotic_pharmacok3.88390823
7MP0010329_abnormal_lipoprotein_level3.09241583
8MP0003252_abnormal_bile_duct2.91374849
9MP0009840_abnormal_foam_cell2.64677726
10MP0003635_abnormal_synaptic_transmissio2.39677336
11MP0005083_abnormal_biliary_tract2.35560376
12MP0002822_catalepsy2.30004280
13MP0003806_abnormal_nucleotide_metabolis2.20640281
14MP0005332_abnormal_amino_acid2.11638028
15MP0003329_amyloid_beta_deposits2.11151212
16MP0004270_analgesia2.07638964
17MP0003195_calcinosis2.00395033
18MP0003123_paternal_imprinting1.98669681
19MP0001666_abnormal_nutrient_absorption1.94054907
20MP0002063_abnormal_learning/memory/cond1.92204069
21MP0009745_abnormal_behavioral_response1.89423922
22MP0003880_abnormal_central_pattern1.88025799
23MP0002118_abnormal_lipid_homeostasis1.84820001
24MP0003191_abnormal_cellular_cholesterol1.82546644
25MP0002064_seizures1.78988625
26MP0000604_amyloidosis1.74653861
27MP0001348_abnormal_lacrimal_gland1.72361656
28MP0000778_abnormal_nervous_system1.60835028
29MP0009046_muscle_twitch1.58798404
30MP0000609_abnormal_liver_physiology1.54536930
31MP0001968_abnormal_touch/_nociception1.53738436
32MP0002249_abnormal_larynx_morphology1.53158332
33MP0005584_abnormal_enzyme/coenzyme_acti1.49628243
34MP0004019_abnormal_vitamin_homeostasis1.48407940
35MP0002572_abnormal_emotion/affect_behav1.44775595
36MP0005423_abnormal_somatic_nervous1.44130851
37MP0009780_abnormal_chondrocyte_physiolo1.41734485
38MP0005623_abnormal_meninges_morphology1.41534845
39MP0002909_abnormal_adrenal_gland1.39374290
40MP0003868_abnormal_feces_composition1.38342898
41MP0002882_abnormal_neuron_morphology1.37859309
42MP0001501_abnormal_sleep_pattern1.37454723
43MP0005319_abnormal_enzyme/_coenzyme1.34672141
44MP0004858_abnormal_nervous_system1.34354656
45MP0004130_abnormal_muscle_cell1.33972755
46MP0005535_abnormal_body_temperature1.31678220
47MP0002272_abnormal_nervous_system1.25679425
48MP0002734_abnormal_mechanical_nocicepti1.25519379
49MP0005409_darkened_coat_color1.25351130
50MP0001905_abnormal_dopamine_level1.23527082
51MP0000566_synostosis1.23268979
52MP0001188_hyperpigmentation1.23253598
53MP0001346_abnormal_lacrimal_gland1.22336195
54MP0002152_abnormal_brain_morphology1.20961485
55MP0001440_abnormal_grooming_behavior1.19373929
56MP0001486_abnormal_startle_reflex1.18430923
57MP0003634_abnormal_glial_cell1.16936116
58MP0003122_maternal_imprinting1.16211489
59MP0003075_altered_response_to1.14348703
60MP0002837_dystrophic_cardiac_calcinosis1.12934902
61MP0008961_abnormal_basal_metabolism1.12826595
62MP0002735_abnormal_chemical_nociception1.12599912
63MP0002736_abnormal_nociception_after1.11246017
64MP0003879_abnormal_hair_cell1.09547833
65MP0002733_abnormal_thermal_nociception1.09494192
66MP0000920_abnormal_myelination1.08661216
67MP0000751_myopathy1.06784780
68MP0001764_abnormal_homeostasis1.06666796
69MP0003633_abnormal_nervous_system1.04893750
70MP0003690_abnormal_glial_cell1.04218821
71MP0008874_decreased_physiological_sensi1.03606687
72MP0000678_abnormal_parathyroid_gland1.02445502
73MP0001849_ear_inflammation1.02430698
74MP0008872_abnormal_physiological_respon1.01881899
75MP0002138_abnormal_hepatobiliary_system1.00562434
76MP0008569_lethality_at_weaning1.00179443
77MP0002078_abnormal_glucose_homeostasis0.99821364
78MP0010234_abnormal_vibrissa_follicle0.97434233
79MP0001529_abnormal_vocalization0.95726997
80MP0004811_abnormal_neuron_physiology0.95095249
81MP0005448_abnormal_energy_balance0.94752446
82MP0003656_abnormal_erythrocyte_physiolo0.93248170
83MP0001986_abnormal_taste_sensitivity0.92736009
84MP0005394_taste/olfaction_phenotype0.91006532
85MP0005499_abnormal_olfactory_system0.91006532
86MP0005386_behavior/neurological_phenoty0.90725792
87MP0004924_abnormal_behavior0.90725792
88MP0003861_abnormal_nervous_system0.90612035
89MP0002876_abnormal_thyroid_physiology0.90212374
90MP0002067_abnormal_sensory_capabilities0.89714223
91MP0004742_abnormal_vestibular_system0.88135831
92MP0002090_abnormal_vision0.88014471
93MP0001970_abnormal_pain_threshold0.86525471
94MP0000003_abnormal_adipose_tissue0.86311494
95MP0001963_abnormal_hearing_physiology0.83456250
96MP0001177_atelectasis0.82325377
97MP0001502_abnormal_circadian_rhythm0.82209237
98MP0003631_nervous_system_phenotype0.81916259
99MP0004510_myositis0.81880202
100MP0002069_abnormal_eating/drinking_beha0.81747810
101MP0003011_delayed_dark_adaptation0.81217682
102MP0005076_abnormal_cell_differentiation0.78352233
103MP0009672_abnormal_birth_weight0.77590985
104MP0002557_abnormal_social/conspecific_i0.77471283
105MP0004885_abnormal_endolymph0.76383587
106MP0002971_abnormal_brown_adipose0.76289566
107MP0002066_abnormal_motor_capabilities/c0.76226457
108MP0003705_abnormal_hypodermis_morpholog0.75666646
109MP0008260_abnormal_autophagy0.74787888
110MP0000579_abnormal_nail_morphology0.74741833
111MP0003787_abnormal_imprinting0.74352274
112MP0005551_abnormal_eye_electrophysiolog0.74313469
113MP0002089_abnormal_postnatal_growth/wei0.73198022
114MP0005670_abnormal_white_adipose0.72863481
115MP0002184_abnormal_innervation0.71091438
116MP0006276_abnormal_autonomic_nervous0.71044806
117MP0005646_abnormal_pituitary_gland0.70767286
118MP0000955_abnormal_spinal_cord0.70617820
119MP0009642_abnormal_blood_homeostasis0.70050586
120MP0001984_abnormal_olfaction0.70016440
121MP0009643_abnormal_urine_homeostasis0.68367810
122MP0005334_abnormal_fat_pad0.67953696
123MP0005166_decreased_susceptibility_to0.67518474
124MP0010769_abnormal_survival0.66788807
125MP0006035_abnormal_mitochondrial_morpho0.66642745
126MP0009764_decreased_sensitivity_to0.66351389
127MP0000598_abnormal_liver_morphology0.66138401
128MP0004142_abnormal_muscle_tone0.65834392
129MP0003953_abnormal_hormone_level0.65662018
130MP0005167_abnormal_blood-brain_barrier0.64765733
131MP0002229_neurodegeneration0.64389705
132MP0001943_abnormal_respiration0.64130861
133MP0005171_absent_coat_pigmentation0.63790608
134MP0006036_abnormal_mitochondrial_physio0.63642288
135MP0000537_abnormal_urethra_morphology0.63589462
136MP0000639_abnormal_adrenal_gland0.63398346
137MP0010768_mortality/aging0.62872077
138MP0003172_abnormal_lysosome_physiology0.62553656
139MP0005636_abnormal_mineral_homeostasis0.61603166
140MP0005084_abnormal_gallbladder_morpholo0.61151477
141MP0001299_abnormal_eye_distance/0.61063892
142MP0000747_muscle_weakness0.60644650
143MP0010770_preweaning_lethality0.60390232
144MP0002082_postnatal_lethality0.60390232
145MP0005410_abnormal_fertilization0.60237963
146MP0002752_abnormal_somatic_nervous0.59820385
147MP0002873_normal_phenotype0.59148482
148MP0002169_no_abnormal_phenotype0.58382376
149MP0003119_abnormal_digestive_system0.57964383
150MP0001731_abnormal_postnatal_growth0.57663252
151MP0002081_perinatal_lethality0.57191569

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.70667686
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.62330511
3Intrahepatic cholestasis (HP:0001406)4.99850385
4Xanthomatosis (HP:0000991)4.84052107
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.76099340
6Hypobetalipoproteinemia (HP:0003563)4.64705054
7Annular pancreas (HP:0001734)4.59419379
8Hyperlipoproteinemia (HP:0010980)4.49790663
9Prolonged partial thromboplastin time (HP:0003645)4.48479792
10Ankle clonus (HP:0011448)4.23837943
11Complement deficiency (HP:0004431)4.19107069
12Obstructive sleep apnea (HP:0002870)4.18483707
13Myokymia (HP:0002411)4.07822096
14Ketosis (HP:0001946)3.73808602
15Cerebral hypomyelination (HP:0006808)3.67459271
16Upper limb amyotrophy (HP:0009129)3.64172245
17Distal upper limb amyotrophy (HP:0007149)3.64172245
18Epidermoid cyst (HP:0200040)3.60908639
19Hyperammonemia (HP:0001987)3.59170836
20Insomnia (HP:0100785)3.56703546
21Hypolipoproteinemia (HP:0010981)3.54473298
22Hand muscle atrophy (HP:0009130)3.46741571
23Hyperglycinemia (HP:0002154)3.41886046
24Focal motor seizures (HP:0011153)3.30068883
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.28084673
26Abnormality of the common coagulation pathway (HP:0010990)3.26877474
27Hyperacusis (HP:0010780)3.26851671
28Hypoalphalipoproteinemia (HP:0003233)3.25810309
29Spastic gait (HP:0002064)3.18623305
30Abnormality of the lower motor neuron (HP:0002366)3.18450204
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.15159297
32Joint hemorrhage (HP:0005261)3.13355473
33Visual hallucinations (HP:0002367)3.12365609
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.06981538
35Hyperglycinuria (HP:0003108)3.06032539
36Turricephaly (HP:0000262)3.02445379
37Abnormality of serine family amino acid metabolism (HP:0010894)2.98264144
38Abnormality of glycine metabolism (HP:0010895)2.98264144
39Diplopia (HP:0000651)2.96129207
40Abnormality of binocular vision (HP:0011514)2.96129207
41Status epilepticus (HP:0002133)2.94794773
42Ketoacidosis (HP:0001993)2.94010798
43Neuronal loss in central nervous system (HP:0002529)2.90331300
44Abnormality of complement system (HP:0005339)2.88921314
45Akinesia (HP:0002304)2.83043351
46Focal seizures (HP:0007359)2.81184223
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.79845701
48Hypercholesterolemia (HP:0003124)2.78421231
49Abnormality of methionine metabolism (HP:0010901)2.75529904
50Hypoglycemic coma (HP:0001325)2.72623951
51Truncal ataxia (HP:0002078)2.72173799
52Delayed CNS myelination (HP:0002188)2.72120725
53Amblyopia (HP:0000646)2.69161206
54Ulnar bowing (HP:0003031)2.67429192
55Cholecystitis (HP:0001082)2.67413804
56Abnormal gallbladder physiology (HP:0012438)2.67413804
57Fat malabsorption (HP:0002630)2.66433282
58Delusions (HP:0000746)2.66316620
59Pointed chin (HP:0000307)2.63499146
60Gout (HP:0001997)2.62751546
61Neonatal onset (HP:0003623)2.62017073
62Peripheral hypomyelination (HP:0007182)2.57986977
63Spontaneous abortion (HP:0005268)2.56993155
64Atonic seizures (HP:0010819)2.56670802
65Torticollis (HP:0000473)2.55506965
66Impaired social interactions (HP:0000735)2.53923182
67Abnormal social behavior (HP:0012433)2.53923182
68Hyperbilirubinemia (HP:0002904)2.53573146
69Skin nodule (HP:0200036)2.52731427
70Abnormality of the intrinsic pathway (HP:0010989)2.52328805
71Conjugated hyperbilirubinemia (HP:0002908)2.51761431
72Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.51160721
73Lower limb amyotrophy (HP:0007210)2.47828316
74Febrile seizures (HP:0002373)2.47698097
75Urinary bladder sphincter dysfunction (HP:0002839)2.47512569
76Action tremor (HP:0002345)2.46083237
77Sleep apnea (HP:0010535)2.44518694
78Focal dystonia (HP:0004373)2.43667693
79Bronchomalacia (HP:0002780)2.40672930
80Hyperventilation (HP:0002883)2.40607804
81Urinary urgency (HP:0000012)2.40246860
82Testicular atrophy (HP:0000029)2.40205458
83Cholelithiasis (HP:0001081)2.37119504
84Poor eye contact (HP:0000817)2.36418523
85Craniofacial dystonia (HP:0012179)2.35019032
86Abnormal gallbladder morphology (HP:0012437)2.34862662
87Abnormality of fatty-acid metabolism (HP:0004359)2.34254297
88Tetraplegia (HP:0002445)2.32004006
89Generalized tonic-clonic seizures (HP:0002069)2.30896522
90Long palpebral fissure (HP:0000637)2.29283148
91Apathy (HP:0000741)2.28259894
92Shallow orbits (HP:0000586)2.26868127
93Papilledema (HP:0001085)2.26608027
94Sensorimotor neuropathy (HP:0007141)2.25808552
95Clonus (HP:0002169)2.24961648
96Absence seizures (HP:0002121)2.21069863
97Rapidly progressive (HP:0003678)2.19960528
98Progressive cerebellar ataxia (HP:0002073)2.19620307
99Stridor (HP:0010307)2.18473982
100Impaired vibration sensation in the lower limbs (HP:0002166)2.17985258
101Epileptic encephalopathy (HP:0200134)2.17313382
102Amyloidosis (HP:0011034)2.15986649
103Mitral stenosis (HP:0001718)2.14825995
104Diminished motivation (HP:0000745)2.14820193
105Postural instability (HP:0002172)2.14768452
106Metabolic acidosis (HP:0001942)2.14607685
107Bradykinesia (HP:0002067)2.14488725
108Supranuclear gaze palsy (HP:0000605)2.14261337
109Irritability (HP:0000737)2.13204164
110Abnormality of serum amino acid levels (HP:0003112)2.12621017
111Cerebral inclusion bodies (HP:0100314)2.12244134
112Achilles tendon contracture (HP:0001771)2.12122555
113Abnormality of purine metabolism (HP:0004352)2.11578789
114Abnormality of nucleobase metabolism (HP:0010932)2.11578146
115Abnormality of pyrimidine metabolism (HP:0004353)2.11576861
116Impaired smooth pursuit (HP:0007772)2.10553335
117Abnormality of the Achilles tendon (HP:0005109)2.09566647
118Broad distal phalanx of finger (HP:0009836)2.08619494
119Aplasia involving bones of the extremities (HP:0009825)2.08112081
120Aplasia involving bones of the upper limbs (HP:0009823)2.08112081
121Aplasia of the phalanges of the hand (HP:0009802)2.08112081
122Neurofibrillary tangles (HP:0002185)2.08099174
123Dysdiadochokinesis (HP:0002075)2.06737798
124Rigidity (HP:0002063)2.05323451
125Hepatocellular carcinoma (HP:0001402)2.02615782
126Mutism (HP:0002300)2.01102976
127Dysmetric saccades (HP:0000641)2.00986987
128Systemic lupus erythematosus (HP:0002725)2.00760490
129Distal sensory impairment (HP:0002936)2.00369590
130Depression (HP:0000716)1.98583676
131Limb dystonia (HP:0002451)1.96232760
132CNS hypomyelination (HP:0003429)1.94843079
133Intention tremor (HP:0002080)1.93984322
134Choreoathetosis (HP:0001266)1.92431819
135Late onset (HP:0003584)1.92209550
136Dialeptic seizures (HP:0011146)1.91975015
137Anxiety (HP:0000739)1.91859223
138Spinal canal stenosis (HP:0003416)1.91840680
139Acanthocytosis (HP:0001927)1.91727830
140Stereotypic behavior (HP:0000733)1.90751412
141Hemiplegia (HP:0002301)1.90187557
142Truncus arteriosus (HP:0001660)1.89934214
143Hypoglycemic seizures (HP:0002173)1.89934162
144Myocardial infarction (HP:0001658)1.88301242
145Global brain atrophy (HP:0002283)1.87925084
146Elfin facies (HP:0004428)1.86824573
147Spastic diplegia (HP:0001264)1.86408408
148Abnormal eating behavior (HP:0100738)1.85569982
149Hyperthyroidism (HP:0000836)1.85558180
150Dysmetria (HP:0001310)1.85478610
151Abnormality of the gallbladder (HP:0005264)1.85249382
152Spastic tetraparesis (HP:0001285)1.84248167
153Lower limb asymmetry (HP:0100559)1.83962655
154EEG with generalized epileptiform discharges (HP:0011198)1.83878373
155Hypsarrhythmia (HP:0002521)1.83679602
156Epileptiform EEG discharges (HP:0011182)1.83577840
157Scanning speech (HP:0002168)1.83247583
158Overriding aorta (HP:0002623)1.82864213
159Broad face (HP:0000283)1.81284855
160Distal lower limb amyotrophy (HP:0008944)1.81024505
161Abnormality of saccadic eye movements (HP:0000570)1.80645358
162Slow saccadic eye movements (HP:0000514)1.78684162
163Hammertoe (HP:0001765)1.78380867
164Lower limb muscle weakness (HP:0007340)1.77453531
165Growth hormone excess (HP:0000845)1.74848000
166Precocious puberty (HP:0000826)1.74531901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.63987423
2EPHA43.39004689
3DAPK23.29339971
4NTRK33.12257515
5MARK12.89840324
6MAP2K42.66205007
7MAP3K42.41335674
8KSR22.39547887
9BCKDK2.38521343
10MINK12.30844339
11PAK62.17584476
12TESK12.17256909
13CAMKK12.10432319
14ERN11.96208515
15FGFR41.81310856
16SMG11.73341796
17TRIB31.69588170
18PRKD31.67922180
19MAP2K71.67506201
20SIK11.65769388
21RIPK11.60993138
22NTRK21.53180308
23DAPK11.49814309
24SIK21.48544218
25TAOK11.48175390
26MAP3K131.47474074
27STK381.45756838
28EEF2K1.44787066
29NTRK11.41960367
30PKN21.34945196
31KSR11.33463938
32PINK11.31989211
33LATS21.29069663
34PRKCG1.23495942
35CDK51.18128961
36ARAF1.13760611
37BRSK11.13410244
38PHKG21.13128610
39PHKG11.13128610
40MAP3K71.09673153
41MAP3K21.09041123
42RET1.08472671
43GRK51.07947748
44BRAF1.05416436
45PRKCH1.01427386
46LIMK10.98232311
47CAMK2B0.98137835
48MAP3K120.97352761
49EPHA20.97276446
50PRKCZ0.91883041
51MST1R0.91819969
52SGK30.91649138
53NEK10.89850139
54IRAK20.89776670
55MAP3K10.88999880
56INSRR0.88230778
57RIPK40.88104685
58TYRO30.87749639
59PDK10.87702496
60CAMK10.86264044
61PDPK10.86161584
62NEK60.86122391
63IRAK30.83513953
64PRKD20.81363900
65PTK20.80549113
66PAK30.79776976
67ALK0.77682366
68LMTK20.75939291
69FES0.75635589
70CAMKK20.75189763
71TESK20.74993237
72MAPK120.74623808
73PRPF4B0.74447709
74STK110.74230429
75SGK2230.72624200
76SGK4940.72624200
77CAMK40.70885324
78ERBB40.70608282
79JAK20.70450333
80CAMK1G0.69950386
81MARK20.69842326
82RAF10.69129586
83SGK20.68338860
84MAPK110.66279515
85CDK120.65272972
86JAK10.63887890
87PRKG20.63022212
88MAPK100.62678720
89CAMK2A0.62042208
90MAP2K60.61399289
91BMX0.60718654
92CAMK2G0.60128705
93RPS6KA20.59065252
94TAOK30.58532529
95MAP2K10.58209230
96SIK30.57567453
97CDK190.57040675
98PRKACG0.56767854
99PLK20.56103232
100DAPK30.54583158
101CDK150.54104643
102ERBB20.52856015
103CSNK1G20.52707009
104CDK180.52440602
105TSSK60.51417735
106RPS6KA30.50477526
107PRKAA10.50337331
108PDGFRA0.50054211
109DYRK1B0.49975867
110ABL20.49016859
111PAK10.47881477
112ICK0.47814586
113PTK60.47687873
114SGK10.47444799
115MAP3K110.46891807
116AURKA0.46461179
117CDK140.46105900
118NME20.45412903
119DYRK1A0.45191111
120MTOR0.45075105
121PTK2B0.44677235
122CDK11A0.43089324
123TAOK20.42717850
124UHMK10.42372894
125GRK60.42247596
126MAP3K50.41064854
127TNK20.40911943
128PRKCI0.40548529
129PAK40.40039560
130MAPK130.39381842
131CAMK1D0.39247214
132FYN0.38840907
133MAPK80.37987159
134MAPK150.37268845
135PIM20.37041033
136MET0.33132079

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.01798243
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.91433644
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.86004198
4Arginine biosynthesis_Homo sapiens_hsa002203.17870485
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48965954
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.19909610
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.16392278
8Tryptophan metabolism_Homo sapiens_hsa003802.06968523
9Butanoate metabolism_Homo sapiens_hsa006502.06112277
10Complement and coagulation cascades_Homo sapiens_hsa046102.00388590
11Fatty acid degradation_Homo sapiens_hsa000711.99976305
12Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.88370124
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83609392
14Bile secretion_Homo sapiens_hsa049761.82567970
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77907259
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72673468
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72234433
18PPAR signaling pathway_Homo sapiens_hsa033201.64131748
19Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.58905778
20Fatty acid metabolism_Homo sapiens_hsa012121.50313099
21Propanoate metabolism_Homo sapiens_hsa006401.45236470
22Synaptic vesicle cycle_Homo sapiens_hsa047211.44818901
23Peroxisome_Homo sapiens_hsa041461.44391746
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.35363309
25Nicotine addiction_Homo sapiens_hsa050331.35010811
26Glioma_Homo sapiens_hsa052141.34996522
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32279992
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.31678413
29Vibrio cholerae infection_Homo sapiens_hsa051101.28234035
30beta-Alanine metabolism_Homo sapiens_hsa004101.24226929
31Caffeine metabolism_Homo sapiens_hsa002321.22803179
32ErbB signaling pathway_Homo sapiens_hsa040121.22554627
33Estrogen signaling pathway_Homo sapiens_hsa049151.21883524
34Melanogenesis_Homo sapiens_hsa049161.21160144
35VEGF signaling pathway_Homo sapiens_hsa043701.21035406
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20838563
37Phenylalanine metabolism_Homo sapiens_hsa003601.20344505
38GABAergic synapse_Homo sapiens_hsa047271.20046780
39Staphylococcus aureus infection_Homo sapiens_hsa051501.14248595
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13469377
41Pyruvate metabolism_Homo sapiens_hsa006201.13319932
42Chemical carcinogenesis_Homo sapiens_hsa052041.12499854
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.12470034
44Biosynthesis of amino acids_Homo sapiens_hsa012301.11609760
45Histidine metabolism_Homo sapiens_hsa003401.08840418
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07142178
47Gap junction_Homo sapiens_hsa045401.05628117
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.04470579
49Axon guidance_Homo sapiens_hsa043601.04190085
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.04127624
51cAMP signaling pathway_Homo sapiens_hsa040241.04125508
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02240922
53Fat digestion and absorption_Homo sapiens_hsa049751.01058454
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.00873247
55Carbon metabolism_Homo sapiens_hsa012001.00631962
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.00130052
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99345041
58Circadian entrainment_Homo sapiens_hsa047130.96749882
59Starch and sucrose metabolism_Homo sapiens_hsa005000.95893092
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94472304
61ABC transporters_Homo sapiens_hsa020100.94439729
62Retinol metabolism_Homo sapiens_hsa008300.93664116
63Glutamatergic synapse_Homo sapiens_hsa047240.93076458
64Tyrosine metabolism_Homo sapiens_hsa003500.92406741
65Inositol phosphate metabolism_Homo sapiens_hsa005620.92337742
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.92032835
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91705527
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91173871
69Olfactory transduction_Homo sapiens_hsa047400.90712904
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90418490
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.86383901
72Oocyte meiosis_Homo sapiens_hsa041140.85498273
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85048709
74Endocytosis_Homo sapiens_hsa041440.83079589
75Long-term potentiation_Homo sapiens_hsa047200.82882961
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81002624
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80372730
78Insulin secretion_Homo sapiens_hsa049110.79555365
79Morphine addiction_Homo sapiens_hsa050320.79227822
80Selenocompound metabolism_Homo sapiens_hsa004500.75504948
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74639199
82Amphetamine addiction_Homo sapiens_hsa050310.74620780
83Glycerolipid metabolism_Homo sapiens_hsa005610.73508363
84Salivary secretion_Homo sapiens_hsa049700.71280526
85Type II diabetes mellitus_Homo sapiens_hsa049300.71244538
86Notch signaling pathway_Homo sapiens_hsa043300.69074267
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67889412
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65685211
89AMPK signaling pathway_Homo sapiens_hsa041520.65276604
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63348013
91Hippo signaling pathway_Homo sapiens_hsa043900.62973428
92mTOR signaling pathway_Homo sapiens_hsa041500.62832373
93Prion diseases_Homo sapiens_hsa050200.61711719
94Dopaminergic synapse_Homo sapiens_hsa047280.61700930
95Pancreatic secretion_Homo sapiens_hsa049720.60520320
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.59680041
97Rap1 signaling pathway_Homo sapiens_hsa040150.59442808
98Fatty acid biosynthesis_Homo sapiens_hsa000610.58970097
99MAPK signaling pathway_Homo sapiens_hsa040100.58751697
100Collecting duct acid secretion_Homo sapiens_hsa049660.57782317
101Non-small cell lung cancer_Homo sapiens_hsa052230.57708981
102Sulfur metabolism_Homo sapiens_hsa009200.57211220
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56586635
104Cholinergic synapse_Homo sapiens_hsa047250.56275473
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55673117
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.55566433
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54875363
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54177014
109Endometrial cancer_Homo sapiens_hsa052130.53802948
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.53623699
111Lysine degradation_Homo sapiens_hsa003100.53263948
112Fatty acid elongation_Homo sapiens_hsa000620.53023854
113Glucagon signaling pathway_Homo sapiens_hsa049220.53012121
114Gastric acid secretion_Homo sapiens_hsa049710.52810734
115Chronic myeloid leukemia_Homo sapiens_hsa052200.51714596
116Pentose phosphate pathway_Homo sapiens_hsa000300.50966916
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50651914
118Serotonergic synapse_Homo sapiens_hsa047260.49628913
119Arginine and proline metabolism_Homo sapiens_hsa003300.47989131
120Choline metabolism in cancer_Homo sapiens_hsa052310.46795344
121Folate biosynthesis_Homo sapiens_hsa007900.46309603
122Wnt signaling pathway_Homo sapiens_hsa043100.45854702
123Vitamin B6 metabolism_Homo sapiens_hsa007500.44901380
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44669860
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43842346
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.43142948
127Sulfur relay system_Homo sapiens_hsa041220.41575833
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41368922
129Ras signaling pathway_Homo sapiens_hsa040140.40619969
130Cocaine addiction_Homo sapiens_hsa050300.40484022
131Oxytocin signaling pathway_Homo sapiens_hsa049210.39343518
132Renin secretion_Homo sapiens_hsa049240.39171531
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38294298
134Insulin resistance_Homo sapiens_hsa049310.37606757
135mRNA surveillance pathway_Homo sapiens_hsa030150.36994649
136Taste transduction_Homo sapiens_hsa047420.36278418
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36216361
138Vitamin digestion and absorption_Homo sapiens_hsa049770.36145163
139Alcoholism_Homo sapiens_hsa050340.35978786
140Calcium signaling pathway_Homo sapiens_hsa040200.35461689
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34977858
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.34671877
143GnRH signaling pathway_Homo sapiens_hsa049120.34099776
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33383972
145Fructose and mannose metabolism_Homo sapiens_hsa000510.32459527
146Long-term depression_Homo sapiens_hsa047300.30775449
147Insulin signaling pathway_Homo sapiens_hsa049100.30352447
148Thyroid hormone synthesis_Homo sapiens_hsa049180.29539967

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