ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of synapse maturation (GO:0090129)	4.81658448
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.65470061
3	L-phenylalanine catabolic process (GO:0006559)	4.65470061
4	cerebellar granule cell differentiation (GO:0021707)	4.55888407
5	synaptic vesicle maturation (GO:0016188)	4.40453835
6	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.35815978
7	L-phenylalanine metabolic process (GO:0006558)	4.35815978
8	amino acid import (GO:0043090)	4.32807601
9	locomotory exploration behavior (GO:0035641)	4.29551273
10	potassium ion homeostasis (GO:0055075)	4.26450947
11	cell communication by electrical coupling (GO:0010644)	4.26192264
12	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.11573811
13	aromatic amino acid family catabolic process (GO:0009074)	4.08555626
14	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	4.08410704
15	axon ensheathment in central nervous system (GO:0032291)	4.06874835
16	central nervous system myelination (GO:0022010)	4.06874835
17	alpha-linolenic acid metabolic process (GO:0036109)	4.06434559
18	cytoskeletal anchoring at plasma membrane (GO:0007016)	4.00301230
19	potassium ion import (GO:0010107)	3.96536921
20	neuromuscular process controlling balance (GO:0050885)	3.95925254
21	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.92924165
22	cellular sodium ion homeostasis (GO:0006883)	3.89859455
23	glutamate metabolic process (GO:0006536)	3.89344545
24	dicarboxylic acid biosynthetic process (GO:0043650)	3.86432038
25	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.82168943
26	glutamate secretion (GO:0014047)	3.79829205
27	gamma-aminobutyric acid transport (GO:0015812)	3.79271669
28	vocalization behavior (GO:0071625)	3.78764860
29	bile acid biosynthetic process (GO:0006699)	3.77890491
30	positive regulation of dendritic spine development (GO:0060999)	3.76974263
31	kynurenine metabolic process (GO:0070189)	3.72470938
32	regulation of ARF protein signal transduction (GO:0032012)	3.72046992
33	neuronal ion channel clustering (GO:0045161)	3.70617542
34	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.70184355
35	regulation of synaptic plasticity (GO:0048167)	3.70160584
36	postsynaptic membrane organization (GO:0001941)	3.66025073
37	regulation of synapse maturation (GO:0090128)	3.63120217
38	indolalkylamine catabolic process (GO:0046218)	3.59635389
39	tryptophan catabolic process (GO:0006569)	3.59635389
40	indole-containing compound catabolic process (GO:0042436)	3.59635389
41	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.55924798
42	synaptic vesicle endocytosis (GO:0048488)	3.55361717
43	regulation of voltage-gated calcium channel activity (GO:1901385)	3.52956032
44	neurotransmitter-gated ion channel clustering (GO:0072578)	3.47905393
45	synaptic vesicle exocytosis (GO:0016079)	3.45138476
46	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.44470003
47	high-density lipoprotein particle remodeling (GO:0034375)	3.43661650
48	neurotransmitter secretion (GO:0007269)	3.43143699
49	regulation of glutamate receptor signaling pathway (GO:1900449)	3.42866061
50	negative regulation of dendrite morphogenesis (GO:0050774)	3.41646997
51	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.41075963
52	regulation of neurotransmitter secretion (GO:0046928)	3.40277551
53	cell communication involved in cardiac conduction (GO:0086065)	3.37438577
54	cerebellar Purkinje cell layer development (GO:0021680)	3.32575126
55	urea metabolic process (GO:0019627)	3.32300339
56	urea cycle (GO:0000050)	3.32300339
57	cellular ketone body metabolic process (GO:0046950)	3.30707280
58	glyoxylate metabolic process (GO:0046487)	3.29921535
59	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.29067138
60	tryptophan metabolic process (GO:0006568)	3.29029552
61	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.24705038
62	regulation of dendritic spine morphogenesis (GO:0061001)	3.24117925
63	regulation of neuronal synaptic plasticity (GO:0048168)	3.23523599
64	cysteine metabolic process (GO:0006534)	3.23080978
65	dicarboxylic acid catabolic process (GO:0043649)	3.22283641
66	regulation of excitatory postsynaptic membrane potential (GO:0060079)	3.21025285
67	bile acid metabolic process (GO:0008206)	3.18885026
68	regulation of long-term neuronal synaptic plasticity (GO:0048169)	3.18762752
69	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	3.18684182
70	activation of protein kinase A activity (GO:0034199)	3.17330968
71	regulation of vesicle fusion (GO:0031338)	3.12783063
72	regulation of synaptic vesicle exocytosis (GO:2000300)	3.12563686
73	sulfur amino acid catabolic process (GO:0000098)	3.12386266
74	negative regulation of fibrinolysis (GO:0051918)	3.12148667
75	dendritic spine organization (GO:0097061)	3.11478226
76	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.10490596
77	positive regulation of neurotransmitter transport (GO:0051590)	3.08792699
78	regulation of synapse structural plasticity (GO:0051823)	3.08442209
79	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.07382926
80	exploration behavior (GO:0035640)	3.06512987
81	lysine metabolic process (GO:0006553)	3.05248741
82	lysine catabolic process (GO:0006554)	3.05248741
83	complement activation, alternative pathway (GO:0006957)	3.04810338
84	nitrogen cycle metabolic process (GO:0071941)	3.03706323
85	reverse cholesterol transport (GO:0043691)	3.03071943
86	alpha-amino acid catabolic process (GO:1901606)	3.02997456
87	regulation of neurotransmitter transport (GO:0051588)	3.02144053
88	cellular modified amino acid catabolic process (GO:0042219)	3.01710222
89	regulation of fibrinolysis (GO:0051917)	3.01164010
90	layer formation in cerebral cortex (GO:0021819)	2.99890191
91	regulation of protein activation cascade (GO:2000257)	2.98763145
92	regulation of dendritic spine development (GO:0060998)	2.98667371
93	serine family amino acid catabolic process (GO:0009071)	2.98643428
94	positive regulation of neurotransmitter secretion (GO:0001956)	2.98064638
95	acidic amino acid transport (GO:0015800)	2.96551346
96	regulation of postsynaptic membrane potential (GO:0060078)	2.95335914
97	positive regulation of dendrite development (GO:1900006)	2.95049375
98	protein carboxylation (GO:0018214)	2.93640037
99	peptidyl-glutamic acid carboxylation (GO:0017187)	2.93640037
100	dendritic spine morphogenesis (GO:0060997)	2.92405391
101	cellular amino acid catabolic process (GO:0009063)	2.90646760
102	protein-lipid complex remodeling (GO:0034368)	2.89804576
103	macromolecular complex remodeling (GO:0034367)	2.89804576
104	plasma lipoprotein particle remodeling (GO:0034369)	2.89804576
105	regulation of synaptic vesicle transport (GO:1902803)	2.88723526
106	protein localization to synapse (GO:0035418)	2.87200958
107	neuron-neuron synaptic transmission (GO:0007270)	2.86501565
108	short-chain fatty acid metabolic process (GO:0046459)	2.85708079
109	aromatic amino acid family metabolic process (GO:0009072)	2.84841486
110	regulation of cholesterol esterification (GO:0010872)	2.84692767
111	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.84590106
112	negative regulation of cholesterol transport (GO:0032375)	2.84212991
113	negative regulation of sterol transport (GO:0032372)	2.84212991
114	neuron cell-cell adhesion (GO:0007158)	2.83682514
115	ketone body metabolic process (GO:1902224)	2.83252899
116	cell migration in hindbrain (GO:0021535)	2.83139693
117	synaptic transmission, glutamatergic (GO:0035249)	2.81531397
118	mating behavior (GO:0007617)	2.80857722
119	dicarboxylic acid transport (GO:0006835)	2.80748533
120	coenzyme catabolic process (GO:0009109)	2.80484102
121	regulation of triglyceride catabolic process (GO:0010896)	2.78947639
122	cellular potassium ion homeostasis (GO:0030007)	2.78676205
123	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	2.78344784
124	regulation of synaptic transmission (GO:0050804)	2.77060514
125	regulation of complement activation (GO:0030449)	2.76503292
126	neuronal action potential propagation (GO:0019227)	2.76022066
127	neuromuscular process (GO:0050905)	2.75132030
128	aspartate family amino acid catabolic process (GO:0009068)	2.74821043
129	regulation of cholesterol homeostasis (GO:2000188)	2.74023574
130	regulation of bile acid biosynthetic process (GO:0070857)	2.74004098
131	acylglycerol homeostasis (GO:0055090)	2.73596805
132	triglyceride homeostasis (GO:0070328)	2.73596805
133	alanine transport (GO:0032328)	2.73244162
134	tyrosine metabolic process (GO:0006570)	2.73107331
135	L-amino acid import (GO:0043092)	2.73041295
136	sodium ion export (GO:0071436)	2.72882328
137	cerebellar Purkinje cell differentiation (GO:0021702)	2.72448330
138	drug catabolic process (GO:0042737)	2.72135098
139	neurotransmitter transport (GO:0006836)	2.71117765
140	neurotransmitter uptake (GO:0001504)	2.70829903
141	regulation of neurotransmitter levels (GO:0001505)	2.70816156
142	long-term memory (GO:0007616)	2.69954472
143	amino-acid betaine metabolic process (GO:0006577)	2.69339891
144	chemosensory behavior (GO:0007635)	2.68785137
145	pyrimidine nucleobase catabolic process (GO:0006208)	2.67930865
146	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.67313351
147	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.66120665
148	glutamate receptor signaling pathway (GO:0007215)	2.65623985
149	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.64084585
150	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.63155039
151	positive regulation of membrane potential (GO:0045838)	2.63030293
152	regulation of cell communication by electrical coupling (GO:0010649)	2.62611143
153	regulation of dendrite morphogenesis (GO:0048814)	2.62502341
154	L-glutamate transport (GO:0015813)	2.62217496
155	membrane depolarization (GO:0051899)	2.61879330
156	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.61367046
157	glycine transport (GO:0015816)	2.60649417
158	neuromuscular synaptic transmission (GO:0007274)	2.60628097
159	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.59803219
160	membrane depolarization during action potential (GO:0086010)	2.58301881
161	establishment of synaptic vesicle localization (GO:0097480)	2.56227035
162	synaptic vesicle transport (GO:0048489)	2.56227035
163	vesicle docking involved in exocytosis (GO:0006904)	2.54820172

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.75218571
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.91714962
3	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.36814196
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.75573927
5	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.64538300
6	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.43710783
7	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.40174985
8	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.37660189
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.36668465
10	DROSHA_22980978_ChIP-Seq_HELA_Human	2.33546025
11	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.21906410
12	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.21644305
13	* RARB_27405468_Chip-Seq_BRAIN_Mouse	2.19680736
14	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.17455157
15	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.17455157
16	REST_21632747_ChIP-Seq_MESCs_Mouse	2.13718267
17	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.11747431
18	* SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.11029797
19	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.07122254
20	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.05333253
21	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.96550284
22	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.96087036
23	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.96082797
24	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.88028385
25	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.87991230
26	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.86344079
27	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.82744431
28	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.81908355
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.78734191
30	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.77439054
31	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.74788559
32	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.73441676
33	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.72789366
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.71244452
35	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.70442460
36	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.69448685
37	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.68459823
38	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.67862962
39	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.65788058
40	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.61207067
41	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.58940905
42	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.52335291
43	AR_21572438_ChIP-Seq_LNCaP_Human	1.49065739
44	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.48180157
45	SMC4_20622854_ChIP-Seq_HELA_Human	1.45771796
46	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.38431464
47	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.36983330
48	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.35769506
49	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.35693814
50	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.35225758
51	CREB1_26743006_Chip-Seq_LNCaP_Human	1.34200545
52	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.33852144
53	RACK7_27058665_Chip-Seq_MCF-7_Human	1.33636725
54	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.33472014
55	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.32076691
56	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.31785278
57	* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.30995320
58	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.29991090
59	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.29813788
60	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.29722794
61	P68_20966046_ChIP-Seq_HELA_Human	1.29197883
62	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.28846251
63	KDM2B_26808549_Chip-Seq_DND41_Human	1.27892070
64	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.23245854
65	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.21464406
66	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.21045738
67	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.20565927
68	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.19719466
69	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.18982339
70	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.14492918
71	SMAD4_21799915_ChIP-Seq_A2780_Human	1.13772450
72	TAF15_26573619_Chip-Seq_HEK293_Human	1.11480878
73	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.08398029
74	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.08287800
75	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.07772126
76	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.07752065
77	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.07057496
78	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.06709356
79	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.06537038
80	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.06192580
81	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.05721073
82	KDM2B_26808549_Chip-Seq_K562_Human	1.05702905
83	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.04023885
84	AR_19668381_ChIP-Seq_PC3_Human	1.03899843
85	OCT4_19829295_ChIP-Seq_ESCs_Human	1.03641948
86	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.03387584
87	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.03299314
88	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.02514559
89	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.01624762
90	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.01124579
91	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00876463
92	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.00831977
93	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.00676882
94	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.99992890
95	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.99711046
96	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.98862562
97	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.98251454
98	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.97513945
99	ZNF263_19887448_ChIP-Seq_K562_Human	0.97455988
100	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.96719295
101	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.95407565
102	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.95300705
103	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.95033377
104	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.94756240
105	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.94283745
106	* GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.93386815
107	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.92525515
108	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.92364207
109	HTT_18923047_ChIP-ChIP_STHdh_Human	0.92007520
110	CTCF_27219007_Chip-Seq_Bcells_Human	0.91792716
111	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91097187
112	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.91008828
113	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.90269907
114	STAT3_23295773_ChIP-Seq_U87_Human	0.89350781
115	AR_25329375_ChIP-Seq_VCAP_Human	0.88865830
116	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.88480324
117	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.88043577
118	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.86925720
119	SA1_27219007_Chip-Seq_Bcells_Human	0.85536327
120	* ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.84430885
121	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.84101550
122	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.83991045
123	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.83816243
124	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.83815148
125	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.83384651
126	CLOCK_20551151_ChIP-Seq_293T_Human	0.83339502
127	* TCF7_22412390_ChIP-Seq_EML_Mouse	0.82978024
128	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.82912539
129	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.82835142
130	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.82468159
131	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.82101229
132	P300_19829295_ChIP-Seq_ESCs_Human	0.82020348
133	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.81627717
134	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.81170251
135	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.80675639
136	RXR_22108803_ChIP-Seq_LS180_Human	0.80522016
137	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.80018752
138	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.79809317
139	AHR_22903824_ChIP-Seq_MCF-7_Human	0.79748458
140	BCAT_22108803_ChIP-Seq_LS180_Human	0.79725548
141	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.79590521
142	KLF4_19829295_ChIP-Seq_ESCs_Human	0.79540351
143	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.78304877
144	LXR_22292898_ChIP-Seq_THP-1_Human	0.76893612
145	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.75539806
146	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.75125786
147	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.74398182
148	* TCF4_23295773_ChIP-Seq_U87_Human	0.74375913

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	5.18016750
2	MP0002139_abnormal_hepatobiliary_system	5.05860781
3	MP0005360_urolithiasis	4.42052794
4	MP0005085_abnormal_gallbladder_physiolo	3.99149301
5	MP0005365_abnormal_bile_salt	3.80035022
6	MP0002822_catalepsy	3.13449689
7	MP0008875_abnormal_xenobiotic_pharmacok	3.07917981
8	MP0003635_abnormal_synaptic_transmissio	3.06458802
9	MP0003880_abnormal_central_pattern	2.83889131
10	MP0004270_analgesia	2.59304100
11	MP0009745_abnormal_behavioral_response	2.56568621
12	MP0002063_abnormal_learning/memory/cond	2.47753886
13	MP0010329_abnormal_lipoprotein_level	2.45488364
14	MP0002064_seizures	2.37672905
15	MP0003252_abnormal_bile_duct	2.32939577
16	MP0009046_muscle_twitch	2.08797456
17	MP0001486_abnormal_startle_reflex	2.02496060
18	MP0002572_abnormal_emotion/affect_behav	1.98773809
19	MP0003329_amyloid_beta_deposits	1.97096485
20	MP0005423_abnormal_somatic_nervous	1.92753908
21	MP0005332_abnormal_amino_acid	1.90624071
22	MP0001968_abnormal_touch/_nociception	1.85050307
23	MP0009780_abnormal_chondrocyte_physiolo	1.83527569
24	MP0002272_abnormal_nervous_system	1.83393538
25	MP0003123_paternal_imprinting	1.79762492
26	MP0005083_abnormal_biliary_tract	1.78771239
27	MP0003195_calcinosis	1.74645496
28	MP0001501_abnormal_sleep_pattern	1.64955275
29	MP0002734_abnormal_mechanical_nocicepti	1.61506202
30	MP0003690_abnormal_glial_cell	1.57985816
31	MP0002909_abnormal_adrenal_gland	1.56573065
32	MP0002118_abnormal_lipid_homeostasis	1.55204410
33	MP0004885_abnormal_endolymph	1.55029782
34	MP0003806_abnormal_nucleotide_metabolis	1.50231425
35	MP0001666_abnormal_nutrient_absorption	1.49045565
36	MP0000566_synostosis	1.47591977
37	MP0009840_abnormal_foam_cell	1.46969666
38	MP0001440_abnormal_grooming_behavior	1.42859214
39	MP0008569_lethality_at_weaning	1.41576924
40	MP0001346_abnormal_lacrimal_gland	1.40920810
41	MP0000751_myopathy	1.40792391
42	MP0005646_abnormal_pituitary_gland	1.40114564
43	MP0000604_amyloidosis	1.34849989
44	MP0005623_abnormal_meninges_morphology	1.34163115
45	MP0003705_abnormal_hypodermis_morpholog	1.33276638
46	MP0002736_abnormal_nociception_after	1.32205016
47	MP0003633_abnormal_nervous_system	1.30408715
48	MP0003868_abnormal_feces_composition	1.30265379
49	MP0005584_abnormal_enzyme/coenzyme_acti	1.28355174
50	MP0004858_abnormal_nervous_system	1.26105204
51	MP0005535_abnormal_body_temperature	1.25365314
52	MP0002067_abnormal_sensory_capabilities	1.25274086
53	MP0002733_abnormal_thermal_nociception	1.24377607
54	MP0004130_abnormal_muscle_cell	1.24168771
55	MP0002249_abnormal_larynx_morphology	1.22185364
56	MP0002557_abnormal_social/conspecific_i	1.18906520
57	MP0003879_abnormal_hair_cell	1.18477847
58	MP0004924_abnormal_behavior	1.17783809
59	MP0005386_behavior/neurological_phenoty	1.17783809
60	MP0003075_altered_response_to	1.16599510
61	MP0004019_abnormal_vitamin_homeostasis	1.16285216
62	MP0003283_abnormal_digestive_organ	1.15954366
63	MP0003122_maternal_imprinting	1.15269755
64	MP0008872_abnormal_physiological_respon	1.14266656
65	MP0005409_darkened_coat_color	1.14245979
66	MP0002735_abnormal_chemical_nociception	1.12166826
67	MP0001970_abnormal_pain_threshold	1.12033963
68	MP0008874_decreased_physiological_sensi	1.11816258
69	MP0004811_abnormal_neuron_physiology	1.11538934
70	MP0001348_abnormal_lacrimal_gland	1.09608166
71	MP0000955_abnormal_spinal_cord	1.05895934
72	MP0003631_nervous_system_phenotype	1.05766817
73	MP0000778_abnormal_nervous_system	1.05567923
74	MP0001502_abnormal_circadian_rhythm	1.03978253
75	MP0002066_abnormal_motor_capabilities/c	1.03242471
76	MP0003191_abnormal_cellular_cholesterol	1.02515429
77	MP0001984_abnormal_olfaction	1.01324744
78	MP0009379_abnormal_foot_pigmentation	1.01142063
79	MP0000609_abnormal_liver_physiology	0.98686282
80	MP0004142_abnormal_muscle_tone	0.97172598
81	MP0002090_abnormal_vision	0.95292756
82	MP0002089_abnormal_postnatal_growth/wei	0.95093177
83	MP0010234_abnormal_vibrissa_follicle	0.93360260
84	MP0004043_abnormal_pH_regulation	0.93243978
85	MP0003787_abnormal_imprinting	0.93141079
86	MP0000747_muscle_weakness	0.92360203
87	MP0002069_abnormal_eating/drinking_beha	0.92166593
88	MP0000579_abnormal_nail_morphology	0.91486283
89	MP0000920_abnormal_myelination	0.91469553
90	MP0005167_abnormal_blood-brain_barrier	0.90518405
91	MP0002876_abnormal_thyroid_physiology	0.89329160
92	MP0004742_abnormal_vestibular_system	0.89018237
93	MP0002184_abnormal_innervation	0.88940419
94	MP0005551_abnormal_eye_electrophysiolog	0.88462452
95	MP0001963_abnormal_hearing_physiology	0.88272441
96	MP0002882_abnormal_neuron_morphology	0.88089283
97	MP0001177_atelectasis	0.87815126
98	MP0000678_abnormal_parathyroid_gland	0.87619884
99	MP0008961_abnormal_basal_metabolism	0.86011929
100	MP0002837_dystrophic_cardiac_calcinosis	0.85821094
101	MP0005319_abnormal_enzyme/_coenzyme	0.84511167
102	MP0002229_neurodegeneration	0.83276029
103	MP0005670_abnormal_white_adipose	0.80959348
104	MP0003632_abnormal_nervous_system	0.79838648
105	MP0002078_abnormal_glucose_homeostasis	0.78208508
106	MP0006276_abnormal_autonomic_nervous	0.76995390
107	MP0003938_abnormal_ear_development	0.76932952
108	MP0004145_abnormal_muscle_electrophysio	0.74109987
109	MP0001485_abnormal_pinna_reflex	0.72034663
110	MP0003861_abnormal_nervous_system	0.69986105
111	MP0002152_abnormal_brain_morphology	0.67238474
112	MP0004085_abnormal_heartbeat	0.66982690
113	MP0005448_abnormal_energy_balance	0.66130275
114	MP0002138_abnormal_hepatobiliary_system	0.65915219
115	MP0004087_abnormal_muscle_fiber	0.65525638
116	MP0003137_abnormal_impulse_conducting	0.64526652
117	MP0001299_abnormal_eye_distance/	0.63555231
118	MP0010769_abnormal_survival	0.63089496
119	MP0000639_abnormal_adrenal_gland	0.62572108
120	MP0003953_abnormal_hormone_level	0.61115305
121	MP0003634_abnormal_glial_cell	0.61075746
122	MP0000462_abnormal_digestive_system	0.60835213
123	MP0001905_abnormal_dopamine_level	0.60647048
124	MP0009672_abnormal_birth_weight	0.59036418
125	MP0003183_abnormal_peptide_metabolism	0.58495504
126	MP0001943_abnormal_respiration	0.58287841
127	MP0010768_mortality/aging	0.58219514
128	MP0005647_abnormal_sex_gland	0.57786123
129	MP0000026_abnormal_inner_ear	0.57591890
130	MP0004233_abnormal_muscle_weight	0.57154889
131	MP0000534_abnormal_ureter_morphology	0.56990327
132	MP0005166_decreased_susceptibility_to	0.56974508
133	MP0005645_abnormal_hypothalamus_physiol	0.56806465
134	MP0004147_increased_porphyrin_level	0.56572946
135	MP0002971_abnormal_brown_adipose	0.55923301
136	MP0002082_postnatal_lethality	0.55763999
137	MP0010770_preweaning_lethality	0.55763999
138	MP0000759_abnormal_skeletal_muscle	0.55198726
139	MP0001764_abnormal_homeostasis	0.54525486
140	MP0000681_abnormal_thyroid_gland	0.54487199
141	MP0001529_abnormal_vocalization	0.53823423
142	MP0005187_abnormal_penis_morphology	0.53280453

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	5.28253815
2	Deep venous thrombosis (HP:0002625)	5.13276275
3	Focal motor seizures (HP:0011153)	4.85524289
4	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.71389988
5	Intrahepatic cholestasis (HP:0001406)	4.40939849
6	Obstructive sleep apnea (HP:0002870)	4.02976532
7	Hyperlipoproteinemia (HP:0010980)	3.99751027
8	Xanthomatosis (HP:0000991)	3.92589715
9	Prolonged partial thromboplastin time (HP:0003645)	3.89057305
10	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.75821059
11	Focal seizures (HP:0007359)	3.70625367
12	Abnormality of binocular vision (HP:0011514)	3.68555683
13	Diplopia (HP:0000651)	3.68555683
14	Hypobetalipoproteinemia (HP:0003563)	3.62674042
15	Complement deficiency (HP:0004431)	3.52168549
16	Annular pancreas (HP:0001734)	3.51944984
17	Visual hallucinations (HP:0002367)	3.32207750
18	Insomnia (HP:0100785)	3.32101842
19	Hyperglycinemia (HP:0002154)	3.30267428
20	Ketosis (HP:0001946)	3.28996451
21	Action tremor (HP:0002345)	3.26774660
22	Hyperammonemia (HP:0001987)	3.22340502
23	Status epilepticus (HP:0002133)	3.14630208
24	Epidermoid cyst (HP:0200040)	3.06380489
25	Hyperventilation (HP:0002883)	3.00960257
26	Delayed CNS myelination (HP:0002188)	2.97933833
27	Abnormality of serine family amino acid metabolism (HP:0010894)	2.92786019
28	Abnormality of glycine metabolism (HP:0010895)	2.92786019
29	Generalized tonic-clonic seizures (HP:0002069)	2.88860414
30	Torticollis (HP:0000473)	2.86592558
31	Progressive cerebellar ataxia (HP:0002073)	2.85282811
32	Impaired social interactions (HP:0000735)	2.83157756
33	Abnormal social behavior (HP:0012433)	2.83157756
34	Hyperglycinuria (HP:0003108)	2.82692802
35	Dysdiadochokinesis (HP:0002075)	2.82265987
36	Epileptic encephalopathy (HP:0200134)	2.81295927
37	Abnormality of the lower motor neuron (HP:0002366)	2.80442983
38	Hypolipoproteinemia (HP:0010981)	2.79393307
39	Poor eye contact (HP:0000817)	2.77691584
40	Postural instability (HP:0002172)	2.75381294
41	Focal dystonia (HP:0004373)	2.73209909
42	Bundle branch block (HP:0011710)	2.70767179
43	Hyperacusis (HP:0010780)	2.69011590
44	Neurofibrillary tangles (HP:0002185)	2.66706341
45	Intention tremor (HP:0002080)	2.66476491
46	Truncal ataxia (HP:0002078)	2.65648367
47	Absence seizures (HP:0002121)	2.64954525
48	Hypoalphalipoproteinemia (HP:0003233)	2.64497901
49	Cerebral hypomyelination (HP:0006808)	2.63473832
50	Ketoacidosis (HP:0001993)	2.63462266
51	Impaired vibration sensation in the lower limbs (HP:0002166)	2.62342829
52	Joint hemorrhage (HP:0005261)	2.59659486
53	Abnormality of the common coagulation pathway (HP:0010990)	2.59373370
54	Anxiety (HP:0000739)	2.59137128
55	Conjugated hyperbilirubinemia (HP:0002908)	2.58018286
56	Craniofacial dystonia (HP:0012179)	2.57195081
57	Akinesia (HP:0002304)	2.52501990
58	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.51731387
59	Papilledema (HP:0001085)	2.50520857
60	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.49865505
61	Supranuclear gaze palsy (HP:0000605)	2.49718019
62	Dysmetria (HP:0001310)	2.48683494
63	Hypoglycemic coma (HP:0001325)	2.48190512
64	Bronchomalacia (HP:0002780)	2.47433998
65	Gout (HP:0001997)	2.46262993
66	Peripheral hypomyelination (HP:0007182)	2.45299200
67	Aplasia involving bones of the extremities (HP:0009825)	2.43969819
68	Aplasia involving bones of the upper limbs (HP:0009823)	2.43969819
69	Aplasia of the phalanges of the hand (HP:0009802)	2.43969819
70	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.41624299
71	Febrile seizures (HP:0002373)	2.40507860
72	Sleep apnea (HP:0010535)	2.39555356
73	Limb dystonia (HP:0002451)	2.39367325
74	Cerebral inclusion bodies (HP:0100314)	2.37970528
75	Depression (HP:0000716)	2.37302698
76	Dialeptic seizures (HP:0011146)	2.36934287
77	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.34507605
78	Abnormal eating behavior (HP:0100738)	2.32239216
79	Neuronal loss in central nervous system (HP:0002529)	2.31062148
80	Lower limb amyotrophy (HP:0007210)	2.30792042
81	Neonatal onset (HP:0003623)	2.26955741
82	Fat malabsorption (HP:0002630)	2.25297651
83	Hypercholesterolemia (HP:0003124)	2.25285012
84	Abnormality of methionine metabolism (HP:0010901)	2.25018292
85	Atonic seizures (HP:0010819)	2.24886887
86	Abnormality of complement system (HP:0005339)	2.24787469
87	Urinary bladder sphincter dysfunction (HP:0002839)	2.23561884
88	Ankle clonus (HP:0011448)	2.22724460
89	Scanning speech (HP:0002168)	2.19576158
90	Gaze-evoked nystagmus (HP:0000640)	2.18014149
91	Rigidity (HP:0002063)	2.17752911
92	Clonus (HP:0002169)	2.17749392
93	Tetraplegia (HP:0002445)	2.17700655
94	Hemiplegia (HP:0002301)	2.16248867
95	Pointed chin (HP:0000307)	2.15089667
96	Impaired vibratory sensation (HP:0002495)	2.14687128
97	Heart block (HP:0012722)	2.14367603
98	Delusions (HP:0000746)	2.12822448
99	Sensorimotor neuropathy (HP:0007141)	2.12466338
100	Overriding aorta (HP:0002623)	2.10563586
101	Foot dorsiflexor weakness (HP:0009027)	2.09046814
102	Dysmetric saccades (HP:0000641)	2.08958369
103	Abnormal atrioventricular conduction (HP:0005150)	2.08363706
104	Broad-based gait (HP:0002136)	2.07646433
105	Hyperbilirubinemia (HP:0002904)	2.07246885
106	Spastic gait (HP:0002064)	2.06598032
107	Sudden death (HP:0001699)	2.05038444
108	Spontaneous abortion (HP:0005268)	2.03642020
109	Distal upper limb amyotrophy (HP:0007149)	2.03126553
110	Upper limb amyotrophy (HP:0009129)	2.03126553
111	Genetic anticipation (HP:0003743)	2.00430856
112	Abnormal gallbladder physiology (HP:0012438)	2.00320805
113	Cholecystitis (HP:0001082)	2.00320805
114	Skin nodule (HP:0200036)	1.99841986
115	Ventricular fibrillation (HP:0001663)	1.99640319
116	Hyperparathyroidism (HP:0000843)	1.99179888
117	Generalized myoclonic seizures (HP:0002123)	1.98909597
118	Hyporeflexia of lower limbs (HP:0002600)	1.98490711
119	Lower limb muscle weakness (HP:0007340)	1.97460159
120	Hyperthyroidism (HP:0000836)	1.97459059
121	Increased circulating renin level (HP:0000848)	1.96700905
122	Amblyopia (HP:0000646)	1.95401033
123	Shallow orbits (HP:0000586)	1.94942121
124	Apathy (HP:0000741)	1.94845100
125	Megalencephaly (HP:0001355)	1.94449378
126	Abnormality of the foot musculature (HP:0001436)	1.93790968
127	Mutism (HP:0002300)	1.93577364
128	Hypsarrhythmia (HP:0002521)	1.93359389
129	EEG with generalized epileptiform discharges (HP:0011198)	1.93319354
130	Epileptiform EEG discharges (HP:0011182)	1.92950669
131	Confusion (HP:0001289)	1.92138448
132	Stereotypic behavior (HP:0000733)	1.92017844
133	Truncus arteriosus (HP:0001660)	1.91485752
134	Spastic tetraparesis (HP:0001285)	1.91451084
135	Hypoglycemic seizures (HP:0002173)	1.90927721
136	Atrioventricular block (HP:0001678)	1.90877379
137	Abnormality of the intrinsic pathway (HP:0010989)	1.90776083
138	Lower limb asymmetry (HP:0100559)	1.90714229
139	Amyloidosis (HP:0011034)	1.90154397
140	Abnormality of the Achilles tendon (HP:0005109)	1.90012069
141	Bradykinesia (HP:0002067)	1.89490603
142	Exercise-induced myalgia (HP:0003738)	1.88659054
143	Abnormality of serum amino acid levels (HP:0003112)	1.86741307
144	Elfin facies (HP:0004428)	1.86434623
145	Abnormality of the periventricular white matter (HP:0002518)	1.86210283
146	Hammertoe (HP:0001765)	1.85869726
147	Urinary urgency (HP:0000012)	1.83733140
148	Turricephaly (HP:0000262)	1.83688601
149	Rapidly progressive (HP:0003678)	1.83629438
150	Drooling (HP:0002307)	1.83191931
151	Spinal canal stenosis (HP:0003416)	1.82394617
152	Athetosis (HP:0002305)	1.78855805
153	Choreoathetosis (HP:0001266)	1.75719659
154	Bowel incontinence (HP:0002607)	1.74871617

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	4.54264110
2	NTRK3	3.51509974
3	MAP3K9	3.21803777
4	DAPK2	3.07034773
5	MARK1	2.75532934
6	MAP3K4	2.54694356
7	MAP2K4	2.34487102
8	PAK6	2.23844454
9	PRKD3	2.20823327
10	MINK1	2.20483779
11	CAMKK1	2.18213516
12	NTRK2	2.07574800
13	KSR2	2.00745854
14	MAP2K7	1.97387290
15	NTRK1	1.67768591
16	TRIB3	1.67112692
17	STK38	1.60867641
18	EEF2K	1.60128208
19	PINK1	1.58445946
20	BCKDK	1.47272108
21	CDK5	1.38176791
22	SGK223	1.37028521
23	SGK494	1.37028521
24	TYRO3	1.30700516
25	KSR1	1.28782282
26	SGK3	1.26010687
27	SGK2	1.24148170
28	MAP3K13	1.23978893
29	PRKCG	1.21041018
30	DAPK1	1.19815786
31	TNIK	1.17560605
32	SIK2	1.16630850
33	SIK1	1.14275245
34	CAMK1G	1.14046429
35	MAP3K2	1.11162716
36	PHKG2	1.10170262
37	PHKG1	1.10170262
38	TAOK1	1.07961454
39	PRPF4B	1.07880110
40	MAP3K7	1.06059140
41	BRSK1	1.05810531
42	PRKCH	1.04998857
43	FES	1.03816021
44	CAMK1	1.00180812
45	FGFR2	0.98572946
46	RET	0.98251301
47	PDPK1	0.93519650
48	STK11	0.93440403
49	LMTK2	0.90976659
50	RIPK1	0.90927545
51	SMG1	0.90418767
52	BRAF	0.90093862
53	RIPK4	0.88895563
54	GRK5	0.88600628
55	PDK1	0.85826825
56	PRKCZ	0.83148766
57	CAMK2A	0.83093929
58	CAMKK2	0.81864033
59	INSRR	0.81176029
60	LIMK1	0.79957458
61	PAK3	0.78974640
62	ARAF	0.78107610
63	LATS2	0.77462737
64	UHMK1	0.77322864
65	PLK2	0.76591603
66	OXSR1	0.75959176
67	MAPK10	0.73854251
68	CDK19	0.73514224
69	TESK1	0.70941942
70	SGK1	0.70897751
71	FGFR4	0.69909585
72	WNK1	0.69634702
73	MAPK13	0.68561807
74	CAMK2G	0.67331111
75	MAP3K1	0.66534343
76	CAMK4	0.65766425
77	CAMK2B	0.65679764
78	CDK15	0.64907474
79	MARK2	0.63808057
80	PKN2	0.63707922
81	PNCK	0.63592744
82	PDGFRA	0.63464912
83	DAPK3	0.63460221
84	CDK18	0.62587836
85	CSNK1G2	0.62366628
86	CAMK1D	0.61606720
87	ALK	0.61170348
88	PRKG2	0.60665758
89	CDK14	0.59143021
90	MAP3K11	0.58554601
91	MAP3K12	0.58358749
92	ROCK2	0.57910838
93	RPS6KA3	0.57397490
94	CDK12	0.56827869
95	ICK	0.56601038
96	PTK2B	0.53865971
97	CDK11A	0.53282971
98	CAMK2D	0.51747977
99	ERBB2	0.51740275
100	PTK2	0.51359181
101	MAPK12	0.51270282
102	PRKACG	0.50406250
103	RAF1	0.48661838
104	CASK	0.48061593
105	DYRK1A	0.47951106
106	CDC42BPA	0.46922487
107	TNK2	0.46764986
108	IRAK2	0.46272900
109	ERBB4	0.46054719
110	FYN	0.45198704
111	DMPK	0.44958869
112	NEK1	0.43807271
113	AKT2	0.43545267
114	PKN1	0.43051689
115	MAP2K1	0.42256805
116	NEK6	0.41351232
117	MAPKAPK5	0.40793157
118	PRKAA1	0.39722053
119	ROCK1	0.39143869
120	EPHA2	0.37209488
121	TTN	0.37165458
122	MTOR	0.34518729
123	RPS6KA2	0.33360862
124	TAOK2	0.33000542

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	5.29054953
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.21676238
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.83087230
4	Arginine biosynthesis_Homo sapiens_hsa00220	2.78064842
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.15930096
6	Butanoate metabolism_Homo sapiens_hsa00650	2.09867840
7	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.05078890
8	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.92055538
9	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.86944018
10	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.85910995
11	Nicotine addiction_Homo sapiens_hsa05033	1.80191886
12	Fatty acid degradation_Homo sapiens_hsa00071	1.70779963
13	Bile secretion_Homo sapiens_hsa04976	1.69629144
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.68428716
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.60982413
16	GABAergic synapse_Homo sapiens_hsa04727	1.60250612
17	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.59815322
18	Complement and coagulation cascades_Homo sapiens_hsa04610	1.52184788
19	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.48962846
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.45604080
21	Fatty acid metabolism_Homo sapiens_hsa01212	1.45087586
22	Propanoate metabolism_Homo sapiens_hsa00640	1.39867712
23	PPAR signaling pathway_Homo sapiens_hsa03320	1.38480905
24	Olfactory transduction_Homo sapiens_hsa04740	1.37675610
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.36321456
26	Circadian entrainment_Homo sapiens_hsa04713	1.32772896
27	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25328565
28	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.23924980
29	Morphine addiction_Homo sapiens_hsa05032	1.21880468
30	Melanogenesis_Homo sapiens_hsa04916	1.20243109
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.19368674
32	Peroxisome_Homo sapiens_hsa04146	1.18894971
33	Long-term potentiation_Homo sapiens_hsa04720	1.17581957
34	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.16958145
35	Amphetamine addiction_Homo sapiens_hsa05031	1.16204400
36	beta-Alanine metabolism_Homo sapiens_hsa00410	1.15063581
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.12120039
38	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.11946820
39	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.08836959
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07063156
41	Salivary secretion_Homo sapiens_hsa04970	1.06543139
42	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.06433471
43	Insulin secretion_Homo sapiens_hsa04911	1.05312404
44	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.04491495
45	ErbB signaling pathway_Homo sapiens_hsa04012	1.03890701
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03574977
47	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.01232575
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94881056
49	Dopaminergic synapse_Homo sapiens_hsa04728	0.94805938
50	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.94329752
51	Gastric acid secretion_Homo sapiens_hsa04971	0.93386082
52	Histidine metabolism_Homo sapiens_hsa00340	0.90199138
53	VEGF signaling pathway_Homo sapiens_hsa04370	0.89998638
54	Cholinergic synapse_Homo sapiens_hsa04725	0.88463543
55	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.87933196
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.87392245
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87390941
58	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.86658710
59	Phenylalanine metabolism_Homo sapiens_hsa00360	0.86120370
60	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.83100069
61	Caffeine metabolism_Homo sapiens_hsa00232	0.81173602
62	Cocaine addiction_Homo sapiens_hsa05030	0.80403114
63	Retinol metabolism_Homo sapiens_hsa00830	0.78439432
64	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.78164071
65	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.77977355
66	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.76403144
67	Insulin signaling pathway_Homo sapiens_hsa04910	0.75838485
68	Axon guidance_Homo sapiens_hsa04360	0.74668127
69	ABC transporters_Homo sapiens_hsa02010	0.74265179
70	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.73529472
71	Tyrosine metabolism_Homo sapiens_hsa00350	0.72702072
72	Vibrio cholerae infection_Homo sapiens_hsa05110	0.72487847
73	Fatty acid elongation_Homo sapiens_hsa00062	0.72401803
74	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.71714590
75	Oocyte meiosis_Homo sapiens_hsa04114	0.69916188
76	Type II diabetes mellitus_Homo sapiens_hsa04930	0.69038727
77	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.68862355
78	Sulfur metabolism_Homo sapiens_hsa00920	0.68682920
79	Renin secretion_Homo sapiens_hsa04924	0.68666271
80	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.68231441
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.67799807
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.67079599
83	Carbon metabolism_Homo sapiens_hsa01200	0.66774282
84	AMPK signaling pathway_Homo sapiens_hsa04152	0.66126839
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65230833
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.63897217
87	Taste transduction_Homo sapiens_hsa04742	0.63805291
88	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.63678646
89	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.63168782
90	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.62883183
91	Long-term depression_Homo sapiens_hsa04730	0.61423610
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.60789501
93	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.59104019
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.58606020
95	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.58588014
96	Choline metabolism in cancer_Homo sapiens_hsa05231	0.58327998
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.57671438
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57572650
99	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.57081036
100	Tight junction_Homo sapiens_hsa04530	0.56373881
101	Rap1 signaling pathway_Homo sapiens_hsa04015	0.55366462
102	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.54264702
103	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.54070933
104	Prion diseases_Homo sapiens_hsa05020	0.52498297
105	GnRH signaling pathway_Homo sapiens_hsa04912	0.52286117
106	Glucagon signaling pathway_Homo sapiens_hsa04922	0.51992751
107	MAPK signaling pathway_Homo sapiens_hsa04010	0.51508982
108	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.49257527
109	Endometrial cancer_Homo sapiens_hsa05213	0.47600251
110	Wnt signaling pathway_Homo sapiens_hsa04310	0.47561197
111	Serotonergic synapse_Homo sapiens_hsa04726	0.46812457
112	mTOR signaling pathway_Homo sapiens_hsa04150	0.46408743
113	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.45655735
114	Lysine degradation_Homo sapiens_hsa00310	0.45059445
115	Ras signaling pathway_Homo sapiens_hsa04014	0.44782193
116	Endocytosis_Homo sapiens_hsa04144	0.44513449
117	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.43967247
118	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.43260936
119	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.43102616
120	Steroid biosynthesis_Homo sapiens_hsa00100	0.42602728
121	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.42568859
122	Mineral absorption_Homo sapiens_hsa04978	0.42448146
123	Arginine and proline metabolism_Homo sapiens_hsa00330	0.41500860
124	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.41454720
125	Hippo signaling pathway_Homo sapiens_hsa04390	0.41010464
126	Renal cell carcinoma_Homo sapiens_hsa05211	0.40711570
127	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.40018585
128	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.39832810
129	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.39762006
130	Gap junction_Homo sapiens_hsa04540	0.39567030
131	Glioma_Homo sapiens_hsa05214	0.39366317
132	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.38403973
133	Estrogen signaling pathway_Homo sapiens_hsa04915	0.37224057
134	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36878370
135	Non-small cell lung cancer_Homo sapiens_hsa05223	0.36424872
136	Circadian rhythm_Homo sapiens_hsa04710	0.36065131
137	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.35617327
138	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35473861
139	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.35067158
140	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.34023758
141	Pancreatic secretion_Homo sapiens_hsa04972	0.33844514

SLC25A23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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