ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	6.60604516
2	nuclear pore organization (GO:0006999)	5.76966020
3	DNA replication initiation (GO:0006270)	5.43951653
4	regulation of translational fidelity (GO:0006450)	4.94297486
5	pore complex assembly (GO:0046931)	4.93807047
6	homocysteine metabolic process (GO:0050667)	4.77141476
7	DNA replication checkpoint (GO:0000076)	4.59078772
8	synapsis (GO:0007129)	4.39963337
9	proline biosynthetic process (GO:0006561)	4.23807435
10	DNA strand elongation involved in DNA replication (GO:0006271)	4.18949456
11	mitotic nuclear envelope disassembly (GO:0007077)	4.16429520
12	regulation of centriole replication (GO:0046599)	4.16333739
13	telomere maintenance via semi-conservative replication (GO:0032201)	4.09145892
14	DNA strand elongation (GO:0022616)	4.08271636
15	DNA unwinding involved in DNA replication (GO:0006268)	4.01459949
16	DNA topological change (GO:0006265)	3.89103741
17	regulation of histone H3-K27 methylation (GO:0061085)	3.80568144
18	mitotic chromosome condensation (GO:0007076)	3.77625152
19	proteasome assembly (GO:0043248)	3.77141733
20	membrane disassembly (GO:0030397)	3.75964873
21	nuclear envelope disassembly (GO:0051081)	3.75964873
22	nucleosome disassembly (GO:0006337)	3.72187575
23	protein-DNA complex disassembly (GO:0032986)	3.72187575
24	meiotic chromosome segregation (GO:0045132)	3.66149669
25	regulation of histone H3-K4 methylation (GO:0051569)	3.63144848
26	TOR signaling (GO:0031929)	3.62835438
27	binding of sperm to zona pellucida (GO:0007339)	3.61572928
28	ribosome assembly (GO:0042255)	3.61094514
29	mitotic sister chromatid segregation (GO:0000070)	3.59733916
30	formation of translation preinitiation complex (GO:0001731)	3.59672032
31	male meiosis (GO:0007140)	3.53014862
32	COPI coating of Golgi vesicle (GO:0048205)	3.51810881
33	Golgi transport vesicle coating (GO:0048200)	3.51810881
34	telomere maintenance via recombination (GO:0000722)	3.50983595
35	diterpenoid biosynthetic process (GO:0016102)	3.49210182
36	regulation of centrosome cycle (GO:0046605)	3.48298916
37	sister chromatid segregation (GO:0000819)	3.46614939
38	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.42703847
39	terpenoid biosynthetic process (GO:0016114)	3.41773780
40	tRNA aminoacylation for protein translation (GO:0006418)	3.39813689
41	gas transport (GO:0015669)	3.34982783
42	protein export from nucleus (GO:0006611)	3.32221307
43	resolution of meiotic recombination intermediates (GO:0000712)	3.29649432
44	amino acid activation (GO:0043038)	3.27854231
45	tRNA aminoacylation (GO:0043039)	3.27854231
46	folic acid-containing compound biosynthetic process (GO:0009396)	3.26006562
47	mitotic recombination (GO:0006312)	3.25194448
48	regulation of translational elongation (GO:0006448)	3.20920118
49	rRNA modification (GO:0000154)	3.20645755
50	mRNA cleavage (GO:0006379)	3.15627246
51	rRNA methylation (GO:0031167)	3.15455413
52	regulation of mitotic spindle organization (GO:0060236)	3.14650866
53	nucleobase-containing small molecule interconversion (GO:0015949)	3.11495231
54	DNA synthesis involved in DNA repair (GO:0000731)	3.10326222
55	poly(A)+ mRNA export from nucleus (GO:0016973)	3.09364718
56	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.07976968
57	regulation of RNA export from nucleus (GO:0046831)	3.05349475
58	maturation of 5.8S rRNA (GO:0000460)	3.04978214
59	ribosome biogenesis (GO:0042254)	3.03673134
60	viral mRNA export from host cell nucleus (GO:0046784)	2.99439166
61	regulation of oxidative phosphorylation (GO:0002082)	2.99362355
62	chromosome organization involved in meiosis (GO:0070192)	2.96833005
63	regulation of centrosome duplication (GO:0010824)	2.95406900
64	regulation of oxidative stress-induced neuron death (GO:1903203)	2.94020064
65	nuclear envelope organization (GO:0006998)	2.92516121
66	regulation of hydrogen peroxide-induced cell death (GO:1903205)	2.88915261
67	folic acid metabolic process (GO:0046655)	2.87846867
68	glutamine family amino acid biosynthetic process (GO:0009084)	2.87607709
69	oxygen transport (GO:0015671)	2.84419794
70	erythrocyte maturation (GO:0043249)	2.82795704
71	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	2.81583924
72	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.80476770
73	DNA conformation change (GO:0071103)	2.80419914
74	chromosome segregation (GO:0007059)	2.79734522
75	DNA duplex unwinding (GO:0032508)	2.78290416
76	definitive hemopoiesis (GO:0060216)	2.74663605
77	chromosome condensation (GO:0030261)	2.74478398
78	DNA geometric change (GO:0032392)	2.73468203
79	telomere maintenance via telomere lengthening (GO:0010833)	2.72736449
80	midgut development (GO:0007494)	2.71490695
81	sperm-egg recognition (GO:0035036)	2.71317288
82	sulfur amino acid biosynthetic process (GO:0000097)	2.70147798
83	telomere maintenance (GO:0000723)	2.70032218
84	telomere organization (GO:0032200)	2.68070053
85	protoporphyrinogen IX metabolic process (GO:0046501)	2.67279723
86	tetrahydrofolate metabolic process (GO:0046653)	2.65656390
87	negative regulation of translational initiation (GO:0045947)	2.64767734
88	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.64745883
89	iron ion import (GO:0097286)	2.62273077
90	ribonucleoprotein complex biogenesis (GO:0022613)	2.61955124
91	oxidative phosphorylation (GO:0006119)	2.61681629
92	mRNA export from nucleus (GO:0006406)	2.60077987
93	DNA catabolic process, exonucleolytic (GO:0000738)	2.59937574
94	regulation of nucleobase-containing compound transport (GO:0032239)	2.58889421
95	purine nucleobase biosynthetic process (GO:0009113)	2.57842296
96	IMP biosynthetic process (GO:0006188)	2.57782469
97	proline metabolic process (GO:0006560)	2.55312004
98	positive regulation of ligase activity (GO:0051351)	2.53184005
99	negative regulation of protein acetylation (GO:1901984)	2.52758519
100	histone exchange (GO:0043486)	2.52679832

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	9.23732008
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.72646182
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.57883854
4	ZNF263_19887448_ChIP-Seq_K562_Human	3.21829802
5	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.14735999
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.12866825
7	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.00460412
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.97491742
9	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.80482887
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.75249954
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.57453311
12	AR_21909140_ChIP-Seq_LNCAP_Human	2.54832017
13	DCP1A_22483619_ChIP-Seq_HELA_Human	2.44142615
14	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.39752262
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.36348808
16	XRN2_22483619_ChIP-Seq_HELA_Human	2.28008826
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.15122019
18	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.13080705
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.10295523
20	KDM5A_27292631_Chip-Seq_BREAST_Human	2.05397124
21	NCOR1_26117541_ChIP-Seq_K562_Human	2.03929693
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.94897332
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.92974908
24	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.90555905
25	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.89717810
26	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.89345978
27	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.80879553
28	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.80346108
29	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.78849129
30	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.76093148
31	GABP_19822575_ChIP-Seq_HepG2_Human	1.75483843
32	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.71105466
33	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.68148794
34	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.67882640
35	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.66677740
36	TTF2_22483619_ChIP-Seq_HELA_Human	1.66085716
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.65905088
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.65261946
39	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.60835970
40	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.58110593
41	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.57003207
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.55261884
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.53506182
44	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.43606027
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.41739196
46	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.41084021
47	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.37490640
48	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.37014828
49	TFEB_21752829_ChIP-Seq_HELA_Human	1.34054536
50	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.34000431
51	GATA1_19941826_ChIP-Seq_K562_Human	1.31364759
52	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31132984
53	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.30857987
54	MYC_22102868_ChIP-Seq_BL_Human	1.29843721
55	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.27783814
56	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.27071023
57	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.26763125
58	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.25294276
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22080110
60	GATA1_22025678_ChIP-Seq_K562_Human	1.21935572
61	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.20936335
62	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.19993858
63	CHD1_26751641_Chip-Seq_LNCaP_Human	1.19501306
64	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18325112
65	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16904588
66	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.15486028
67	CIITA_25753668_ChIP-Seq_RAJI_Human	1.15461670
68	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.14163982
69	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13317340
70	SCL_19346495_ChIP-Seq_HPC-7_Human	1.12502092
71	ELF5_23300383_ChIP-Seq_T47D_Human	1.12333675
72	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.12013067
73	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.10274452
74	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.05161254
75	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.04246205
76	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.03089067
77	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.02968959
78	GATA2_19941826_ChIP-Seq_K562_Human	1.02616464
79	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.01534362
80	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.00901691
81	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.00677119
82	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.99910749
83	SPI1_23127762_ChIP-Seq_K562_Human	0.99589870
84	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.96181463
85	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.94918730
86	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.94759300
87	VDR_21846776_ChIP-Seq_THP-1_Human	0.94038658
88	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.92518367
89	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.92323812
90	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.91498172
91	MYC_18940864_ChIP-ChIP_HL60_Human	0.90218041
92	RACK7_27058665_Chip-Seq_MCF-7_Human	0.90065583
93	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.89793832
94	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.89296148
95	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.84215926
96	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.83861341
97	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.83497747
98	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.81869857
99	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.80498731
100	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.80382049

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	3.89149231
2	MP0008995_early_reproductive_senescence	3.81622887
3	MP0004957_abnormal_blastocyst_morpholog	3.37329842
4	MP0004147_increased_porphyrin_level	3.37127507
5	MP0008057_abnormal_DNA_replication	3.29191374
6	MP0005410_abnormal_fertilization	3.11747755
7	MP0003111_abnormal_nucleus_morphology	3.10112891
8	MP0008058_abnormal_DNA_repair	3.10009415
9	MP0003693_abnormal_embryo_hatching	3.07799584
10	MP0002132_abnormal_respiratory_system	3.03362672
11	MP0003786_premature_aging	2.95851179
12	MP0005451_abnormal_body_composition	2.88503140
13	MP0003077_abnormal_cell_cycle	2.59604816
14	MP0005083_abnormal_biliary_tract	2.58544646
15	MP0002160_abnormal_reproductive_system	2.53756395
16	MP0009697_abnormal_copulation	2.47173013
17	MP0006035_abnormal_mitochondrial_morpho	2.15044529
18	MP0008932_abnormal_embryonic_tissue	2.10817055
19	MP0006036_abnormal_mitochondrial_physio	1.97631402
20	MP0004233_abnormal_muscle_weight	1.92331407
21	MP0003718_maternal_effect	1.90268911
22	MP0002877_abnormal_melanocyte_morpholog	1.81761632
23	MP0001929_abnormal_gametogenesis	1.80473516
24	MP0001661_extended_life_span	1.77474478
25	MP0003315_abnormal_perineum_morphology	1.77299203
26	MP0010307_abnormal_tumor_latency	1.77004366
27	MP0005646_abnormal_pituitary_gland	1.70923790
28	MP0008007_abnormal_cellular_replicative	1.68736971
29	MP0000372_irregular_coat_pigmentation	1.67585754
30	MP0000678_abnormal_parathyroid_gland	1.62124347
31	MP0005058_abnormal_lysosome_morphology	1.56336827
32	MP0003136_yellow_coat_color	1.56095254
33	MP0002210_abnormal_sex_determination	1.53601211
34	MP0002009_preneoplasia	1.49419497
35	MP0004264_abnormal_extraembryonic_tissu	1.46832913
36	MP0004381_abnormal_hair_follicle	1.45869011
37	MP0003698_abnormal_male_reproductive	1.40012970
38	MP0003656_abnormal_erythrocyte_physiolo	1.36910647
39	MP0001697_abnormal_embryo_size	1.34274378
40	MP0000350_abnormal_cell_proliferation	1.33449479
41	MP0002080_prenatal_lethality	1.31420316
42	MP0000358_abnormal_cell_content/	1.30838630
43	MP0005076_abnormal_cell_differentiation	1.30371513
44	MP0005408_hypopigmentation	1.29934834
45	MP0001672_abnormal_embryogenesis/_devel	1.28168099
46	MP0005380_embryogenesis_phenotype	1.28168099
47	MP0010234_abnormal_vibrissa_follicle	1.27130307
48	MP0001730_embryonic_growth_arrest	1.26174897
49	MP0005389_reproductive_system_phenotype	1.24003044
50	MP0003806_abnormal_nucleotide_metabolis	1.23149722
51	MP0005187_abnormal_penis_morphology	1.20854966
52	MP0000681_abnormal_thyroid_gland	1.19860144
53	MP0002088_abnormal_embryonic_growth/wei	1.19762217
54	MP0003984_embryonic_growth_retardation	1.19085525
55	MP0005397_hematopoietic_system_phenotyp	1.17115628
56	MP0001545_abnormal_hematopoietic_system	1.17115628
57	MP0000313_abnormal_cell_death	1.16635574
58	MP0001145_abnormal_male_reproductive	1.16503067
59	MP0008004_abnormal_stomach_pH	1.14768212
60	MP0004808_abnormal_hematopoietic_stem	1.13049663
61	MP0002396_abnormal_hematopoietic_system	1.11078179
62	MP0001727_abnormal_embryo_implantation	1.08948926
63	MP0000653_abnormal_sex_gland	1.08561849
64	MP0002086_abnormal_extraembryonic_tissu	1.08410335
65	MP0009780_abnormal_chondrocyte_physiolo	1.07856840
66	MP0001873_stomach_inflammation	1.03255282
67	MP0001881_abnormal_mammary_gland	1.00014652
68	MP0003942_abnormal_urinary_system	0.94638427
69	MP0002161_abnormal_fertility/fecundity	0.94387875
70	MP0002019_abnormal_tumor_incidence	0.89754337
71	MP0005360_urolithiasis	0.84107167
72	MP0001764_abnormal_homeostasis	0.83024135
73	MP0000647_abnormal_sebaceous_gland	0.81599640
74	MP0003123_paternal_imprinting	0.80989188
75	MP0005647_abnormal_sex_gland	0.78893072
76	MP0000462_abnormal_digestive_system	0.78188322
77	MP0002269_muscular_atrophy	0.77688101
78	MP0001919_abnormal_reproductive_system	0.76627964
79	MP0000377_abnormal_hair_follicle	0.76076990
80	MP0002249_abnormal_larynx_morphology	0.74758955
81	MP0003936_abnormal_reproductive_system	0.74630163
82	MP0003959_abnormal_lean_body	0.74051276
83	MP0003705_abnormal_hypodermis_morpholog	0.72234452
84	MP0003186_abnormal_redox_activity	0.72200909
85	MP0009672_abnormal_birth_weight	0.71480956
86	MP0008775_abnormal_heart_ventricle	0.71412983
87	MP0002796_impaired_skin_barrier	0.71283705
88	MP0005501_abnormal_skin_physiology	0.70686589
89	MP0003699_abnormal_female_reproductive	0.70496730
90	MP0002085_abnormal_embryonic_tissue	0.70419335
91	MP0002084_abnormal_developmental_patter	0.70326067
92	MP0003938_abnormal_ear_development	0.70000551
93	MP0000490_abnormal_crypts_of	0.69675088
94	MP0002970_abnormal_white_adipose	0.67573427
95	MP0000747_muscle_weakness	0.65437174
96	MP0000703_abnormal_thymus_morphology	0.65406046
97	MP0005171_absent_coat_pigmentation	0.65319411
98	MP0009931_abnormal_skin_appearance	0.65004653
99	MP0004782_abnormal_surfactant_physiolog	0.63663174
100	MP0000427_abnormal_hair_cycle	0.63257284

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperthyroidism (HP:0000836)	4.93859146
2	Truncus arteriosus (HP:0001660)	4.79113944
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.58289002
4	Chromsome breakage (HP:0040012)	4.56323914
5	Cholecystitis (HP:0001082)	4.03540006
6	Abnormal gallbladder physiology (HP:0012438)	4.03540006
7	Reticulocytosis (HP:0001923)	3.91342850
8	Birth length less than 3rd percentile (HP:0003561)	3.80555882
9	Hypoparathyroidism (HP:0000829)	3.72888805
10	Ankyloglossia (HP:0010296)	3.64950375
11	Concave nail (HP:0001598)	3.62403798
12	Abnormality of reticulocytes (HP:0004312)	3.25568844
13	Bowel incontinence (HP:0002607)	3.20076445
14	Abnormal large intestine physiology (HP:0012700)	3.19035784
15	Seborrheic dermatitis (HP:0001051)	3.11585162
16	Abnormality of the tricuspid valve (HP:0001702)	3.09912314
17	Abnormality of the preputium (HP:0100587)	3.09249657
18	Sparse lateral eyebrow (HP:0005338)	3.01695392
19	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.01490167
20	Abnormality of glycolysis (HP:0004366)	2.94361238
21	Cerebellar dysplasia (HP:0007033)	2.89707079
22	Hypertensive crisis (HP:0100735)	2.84519027
23	Septate vagina (HP:0001153)	2.83191015
24	Increased serum pyruvate (HP:0003542)	2.81068667
25	Abnormality of chromosome stability (HP:0003220)	2.78018884
26	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.72673604
27	Abnormality of cochlea (HP:0000375)	2.68937966
28	Homocystinuria (HP:0002156)	2.68030422
29	Abnormality of homocysteine metabolism (HP:0010919)	2.68030422
30	Pheochromocytoma (HP:0002666)	2.62653440
31	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.53097426
32	Deep philtrum (HP:0002002)	2.53000422
33	Abnormality of oral frenula (HP:0000190)	2.49426515
34	Abnormality of the carotid arteries (HP:0005344)	2.47594118
35	Myelodysplasia (HP:0002863)	2.46534743
36	Meckel diverticulum (HP:0002245)	2.45790660
37	Polycythemia (HP:0001901)	2.45474924
38	Ileus (HP:0002595)	2.43701167
39	Duodenal stenosis (HP:0100867)	2.43682696
40	Small intestinal stenosis (HP:0012848)	2.43682696
41	Abnormality of the ileum (HP:0001549)	2.40385222
42	Breech presentation (HP:0001623)	2.37716275
43	Patellar dislocation (HP:0002999)	2.36032904
44	Relative macrocephaly (HP:0004482)	2.31036747
45	Acute myeloid leukemia (HP:0004808)	2.30113340
46	Microvesicular hepatic steatosis (HP:0001414)	2.25074374
47	Reduced antithrombin III activity (HP:0001976)	2.24601020
48	Ureteral duplication (HP:0000073)	2.20807475
49	Resting tremor (HP:0002322)	2.19036255
50	Poikilocytosis (HP:0004447)	2.18960932
51	Progressive muscle weakness (HP:0003323)	2.18607509
52	Pallor (HP:0000980)	2.18323816
53	Abnormality of DNA repair (HP:0003254)	2.17887966
54	Facial hemangioma (HP:0000329)	2.16935207
55	Premature ovarian failure (HP:0008209)	2.16215666
56	Ragged-red muscle fibers (HP:0003200)	2.15513957
57	Sandal gap (HP:0001852)	2.15072195
58	Acute encephalopathy (HP:0006846)	2.14339660
59	Increased nuchal translucency (HP:0010880)	2.14174148
60	Neuroendocrine neoplasm (HP:0100634)	2.13707048
61	Increased connective tissue (HP:0009025)	2.12832391
62	Atelectasis (HP:0100750)	2.11521017
63	Abnormal hemoglobin (HP:0011902)	2.08536518
64	Self-mutilation (HP:0000742)	2.03550169
65	Lipid accumulation in hepatocytes (HP:0006561)	2.03519379
66	Cafe-au-lait spot (HP:0000957)	2.03431509
67	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.02053914
68	Meningioma (HP:0002858)	2.00002056
69	Duplicated collecting system (HP:0000081)	1.96368574
70	Premature skin wrinkling (HP:0100678)	1.96363074
71	Abnormally folded helix (HP:0008544)	1.94953279
72	Hyperammonemia (HP:0001987)	1.94701851
73	Acanthocytosis (HP:0001927)	1.94676590
74	Flat cornea (HP:0007720)	1.94536442
75	Abnormal mitochondria in muscle tissue (HP:0008316)	1.93771130
76	Ventricular fibrillation (HP:0001663)	1.93613009
77	Sloping forehead (HP:0000340)	1.92252991
78	Short middle phalanx of the 5th finger (HP:0004220)	1.92197485
79	Overlapping toe (HP:0001845)	1.90612910
80	Secondary amenorrhea (HP:0000869)	1.90293061
81	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.89409135
82	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.88383638
83	Tinnitus (HP:0000360)	1.87271484
84	Aplastic anemia (HP:0001915)	1.86838423
85	Reticulocytopenia (HP:0001896)	1.86712609
86	Cerebral edema (HP:0002181)	1.86237180
87	Cholelithiasis (HP:0001081)	1.85719658
88	Adenoma sebaceum (HP:0009720)	1.85387437
89	Angiofibromas (HP:0010615)	1.85387437
90	Morphological abnormality of the inner ear (HP:0011390)	1.84032172
91	Hypoplasia of the uterus (HP:0000013)	1.83513260
92	Colitis (HP:0002583)	1.83022009
93	J-shaped sella turcica (HP:0002680)	1.82948340
94	Short chin (HP:0000331)	1.82701206
95	Abnormality of pyrimidine metabolism (HP:0004353)	1.79649362
96	Cerebral hypomyelination (HP:0006808)	1.79640897
97	Overfolded helix (HP:0000396)	1.79549662
98	Entropion (HP:0000621)	1.77555391
99	Hyperbilirubinemia (HP:0002904)	1.77383146
100	Arteriovenous malformation (HP:0100026)	1.77037357

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	3.39177597
2	PINK1	3.31965837
3	SCYL2	3.15914826
4	BUB1	2.95689150
5	NME2	2.89926307
6	PBK	2.67785073
7	CLK1	2.63924057
8	EEF2K	2.55132795
9	MARK3	2.54556618
10	TTK	2.43672600
11	IRAK3	2.38810427
12	PLK4	2.18715724
13	RPS6KB2	2.18044701
14	NEK2	2.09368355
15	CDC7	2.09341849
16	SRPK1	2.05545394
17	BRSK2	1.94538995
18	MST4	1.94326764
19	KSR2	1.88701327
20	TSSK6	1.88381757
21	WEE1	1.87875801
22	TRIB3	1.86693014
23	BMPR2	1.84895073
24	NEK1	1.81950513
25	ZAK	1.79525455
26	EIF2AK3	1.77206988
27	CCNB1	1.72035309
28	PDK2	1.71262248
29	RIPK4	1.67706608
30	MAPKAPK3	1.53267528
31	NME1	1.51654692
32	RPS6KA5	1.39182231
33	TLK1	1.32393107
34	RAF1	1.28680763
35	PKN2	1.28616011
36	ICK	1.23819393
37	BRSK1	1.21598704
38	MUSK	1.20648319
39	MAP3K2	1.18657292
40	CDK12	1.16764688
41	ATR	1.13317526
42	CHEK2	1.09920589
43	MAP3K8	1.09889100
44	MAP3K10	1.04785432
45	ILK	1.04039257
46	MST1R	1.00671112
47	LATS1	0.95411225
48	SIK1	0.90181877
49	NEK6	0.89308665
50	PLK1	0.89074280
51	AURKB	0.88083330
52	MAPKAPK5	0.86791366
53	CDK7	0.84719798
54	MTOR	0.82043854
55	RPS6KB1	0.81191208
56	BMX	0.78233105
57	RPS6KA4	0.76976957
58	ATM	0.75524806
59	MAP2K7	0.73727430
60	CHEK1	0.73264560
61	MAP2K1	0.72970309
62	LATS2	0.72519055
63	MKNK1	0.71696807
64	RET	0.71565152
65	CDK1	0.68123065
66	ALK	0.66790420
67	PAK1	0.64271739
68	STK3	0.64102956
69	AURKA	0.61272786
70	MYLK	0.60917570
71	CDK3	0.59770902
72	MAP3K1	0.57338963
73	NTRK3	0.56740034
74	CDK2	0.56612329
75	KSR1	0.54226505
76	PTK6	0.53701203
77	WNK4	0.53645980
78	STK4	0.51865505
79	CSNK1E	0.50746276
80	PRKCI	0.49221455
81	LRRK2	0.48895942
82	AKT2	0.48614904
83	PIK3CG	0.48313059
84	CSNK2A2	0.46973147
85	CSNK1A1L	0.46370453
86	CSNK1G3	0.44550822
87	PAK4	0.42186187
88	CSNK2A1	0.41847758
89	PLK3	0.41221562
90	JAK2	0.36281980
91	PAK2	0.35325218
92	EIF2AK2	0.35321058
93	YES1	0.34852637
94	CDK14	0.32887923
95	MAPK10	0.31921180
96	TRPM7	0.30166320
97	BTK	0.26852565
98	GSK3B	0.26194064
99	BRAF	0.25495248
100	STK10	0.25462587

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.05912993
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.73986818
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.36125201
4	Mismatch repair_Homo sapiens_hsa03430	3.10520632
5	RNA transport_Homo sapiens_hsa03013	2.62255796
6	One carbon pool by folate_Homo sapiens_hsa00670	2.56050463
7	Homologous recombination_Homo sapiens_hsa03440	2.41319380
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.32888752
9	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.30161559
10	Cell cycle_Homo sapiens_hsa04110	2.16254844
11	Spliceosome_Homo sapiens_hsa03040	2.15469826
12	Arginine biosynthesis_Homo sapiens_hsa00220	2.03294730
13	Nucleotide excision repair_Homo sapiens_hsa03420	2.01097373
14	Proteasome_Homo sapiens_hsa03050	1.94612297
15	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.88249823
16	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.82154492
17	Pentose phosphate pathway_Homo sapiens_hsa00030	1.80180761
18	Ribosome_Homo sapiens_hsa03010	1.74660742
19	Base excision repair_Homo sapiens_hsa03410	1.74322916
20	Pyruvate metabolism_Homo sapiens_hsa00620	1.68973519
21	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.63265934
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.59373554
23	Basal transcription factors_Homo sapiens_hsa03022	1.58702912
24	mRNA surveillance pathway_Homo sapiens_hsa03015	1.58217175
25	Carbon metabolism_Homo sapiens_hsa01200	1.58142695
26	RNA polymerase_Homo sapiens_hsa03020	1.52075536
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.49746811
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.48063328
29	Thyroid cancer_Homo sapiens_hsa05216	1.34042658
30	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.33048773
31	Olfactory transduction_Homo sapiens_hsa04740	1.30346907
32	Oocyte meiosis_Homo sapiens_hsa04114	1.28746952
33	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.21223646
34	RNA degradation_Homo sapiens_hsa03018	1.20417036
35	Purine metabolism_Homo sapiens_hsa00230	1.18188007
36	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.16222925
37	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.14742443
38	Steroid biosynthesis_Homo sapiens_hsa00100	1.10874720
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.10128778
40	Apoptosis_Homo sapiens_hsa04210	1.08566692
41	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.08552314
42	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.08349286
43	Nitrogen metabolism_Homo sapiens_hsa00910	1.06189446
44	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.05983818
45	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.04674030
46	Acute myeloid leukemia_Homo sapiens_hsa05221	1.03038138
47	Propanoate metabolism_Homo sapiens_hsa00640	1.01515071
48	Butanoate metabolism_Homo sapiens_hsa00650	0.96913281
49	Alcoholism_Homo sapiens_hsa05034	0.95454369
50	Gap junction_Homo sapiens_hsa04540	0.94737781
51	Parkinsons disease_Homo sapiens_hsa05012	0.86277750
52	Viral carcinogenesis_Homo sapiens_hsa05203	0.85064172
53	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.83733773
54	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.82724959
55	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.82639153
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81940930
57	Glutathione metabolism_Homo sapiens_hsa00480	0.81153248
58	Non-small cell lung cancer_Homo sapiens_hsa05223	0.77096152
59	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.73649049
60	Other glycan degradation_Homo sapiens_hsa00511	0.73033812
61	Huntingtons disease_Homo sapiens_hsa05016	0.69968103
62	mTOR signaling pathway_Homo sapiens_hsa04150	0.68794427
63	p53 signaling pathway_Homo sapiens_hsa04115	0.68489084
64	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.62443033
65	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.62171881
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.57984387
67	Insulin signaling pathway_Homo sapiens_hsa04910	0.57111934
68	Oxidative phosphorylation_Homo sapiens_hsa00190	0.56686379
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.53625920
70	Metabolic pathways_Homo sapiens_hsa01100	0.52343121
71	ErbB signaling pathway_Homo sapiens_hsa04012	0.50566537
72	Lysine degradation_Homo sapiens_hsa00310	0.50362543
73	Endometrial cancer_Homo sapiens_hsa05213	0.50327521
74	VEGF signaling pathway_Homo sapiens_hsa04370	0.48559547
75	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.48307654
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47907627
77	Hepatitis B_Homo sapiens_hsa05161	0.44708480
78	Prostate cancer_Homo sapiens_hsa05215	0.44188172
79	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.41657137
80	Small cell lung cancer_Homo sapiens_hsa05222	0.41171718
81	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.40037311
82	Sulfur relay system_Homo sapiens_hsa04122	0.39033288
83	Alzheimers disease_Homo sapiens_hsa05010	0.38945302
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.36888468
85	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.35484697
86	Glioma_Homo sapiens_hsa05214	0.35443322
87	Pancreatic cancer_Homo sapiens_hsa05212	0.31887782
88	MicroRNAs in cancer_Homo sapiens_hsa05206	0.30482103
89	Fatty acid elongation_Homo sapiens_hsa00062	0.30478522
90	Bladder cancer_Homo sapiens_hsa05219	0.30104398
91	Renal cell carcinoma_Homo sapiens_hsa05211	0.29655032
92	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.28713081
93	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.27687797
94	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.27035828
95	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.26130519
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.24613889
97	Galactose metabolism_Homo sapiens_hsa00052	0.22004364
98	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.21819268
99	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.21790251
100	AMPK signaling pathway_Homo sapiens_hsa04152	0.21645265

SLC25A24P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »