SLC25A26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mitochondrial carriers, including SLC25A26, are a family of transport proteins found mostly in the inner membranes of mitochondria. They shuttle metabolites and cofactors through the mitochondrial membrane (Agrimi et al., 2004 [PubMed 14674884]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)8.11084218
2chaperone-mediated protein transport (GO:0072321)7.13567307
3maintenance of protein location in nucleus (GO:0051457)6.92594675
4somite rostral/caudal axis specification (GO:0032525)6.68669720
5negative regulation of epidermis development (GO:0045683)6.48214489
6regulation of response to osmotic stress (GO:0047484)6.47935537
7regulation of mammary gland epithelial cell proliferation (GO:0033599)6.25843401
8negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.06038428
9protein localization to kinetochore (GO:0034501)5.92704751
10negative regulation of telomerase activity (GO:0051974)5.79712588
11regulation of nuclear cell cycle DNA replication (GO:0033262)5.74217147
12muscle organ morphogenesis (GO:0048644)5.61061679
13negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.58263600
14cytidine metabolic process (GO:0046087)5.52988350
15cytidine catabolic process (GO:0006216)5.52988350
16cytidine deamination (GO:0009972)5.52988350
17negative regulation of cell cycle G2/M phase transition (GO:1902750)5.48311750
18regulation of telomere maintenance via telomerase (GO:0032210)5.39538558
19rRNA transcription (GO:0009303)5.38258646
20histone H4-K5 acetylation (GO:0043981)5.36403611
21histone H4-K8 acetylation (GO:0043982)5.36403611
22regulation of cilium movement (GO:0003352)5.31982809
23regulation of MHC class I biosynthetic process (GO:0045343)5.26052057
24energy coupled proton transport, down electrochemical gradient (GO:0015985)5.19152109
25ATP synthesis coupled proton transport (GO:0015986)5.19152109
26negative regulation of epidermal cell differentiation (GO:0045605)5.15798890
27quinone metabolic process (GO:1901661)5.12058481
28rRNA methylation (GO:0031167)5.11193751
29notochord development (GO:0030903)5.09668927
30response to dietary excess (GO:0002021)5.05943349
31histone H4-K12 acetylation (GO:0043983)4.97533944
32phenol-containing compound catabolic process (GO:0019336)4.97210966
33hormone catabolic process (GO:0042447)4.92452140
34coenzyme catabolic process (GO:0009109)4.90067935
35rRNA modification (GO:0000154)4.80073137
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.71881567
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.70955038
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.67920640
39negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.66530015
40DNA deamination (GO:0045006)4.60353825
41tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.58615302
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.58615302
43mitotic sister chromatid segregation (GO:0000070)4.55854693
44protein complex biogenesis (GO:0070271)4.47017666
45primitive streak formation (GO:0090009)4.30654154
46cullin deneddylation (GO:0010388)4.29355983
47protein localization to chromosome, centromeric region (GO:0071459)4.28659923
48regulation of apoptotic process involved in morphogenesis (GO:1902337)4.23133439
49DNA replication-dependent nucleosome organization (GO:0034723)4.22019251
50DNA replication-dependent nucleosome assembly (GO:0006335)4.22019251
51regulation of translation in response to stress (GO:0043555)4.19488783
52establishment of protein localization to mitochondrial membrane (GO:0090151)4.18860477
53negative regulation of telomere maintenance (GO:0032205)4.18831664
54mitochondrial respiratory chain complex assembly (GO:0033108)4.16293612
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.15319790
56heterochromatin organization (GO:0070828)4.14722582
57mitochondrial respiratory chain complex I assembly (GO:0032981)4.13535048
58NADH dehydrogenase complex assembly (GO:0010257)4.13535048
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.13535048
60respiratory chain complex IV assembly (GO:0008535)4.12861010
61cellular modified amino acid catabolic process (GO:0042219)4.10295112
62cytochrome complex assembly (GO:0017004)4.05436940
63histone H4-K16 acetylation (GO:0043984)4.02911033
64branching involved in mammary gland duct morphogenesis (GO:0060444)4.02641407
65DNA replication checkpoint (GO:0000076)4.00278312
66interferon-gamma production (GO:0032609)3.99734885
67positive regulation of DNA-dependent DNA replication (GO:2000105)3.98467968
68protein neddylation (GO:0045116)3.94958696
69water-soluble vitamin biosynthetic process (GO:0042364)3.93954732
70cell fate commitment involved in formation of primary germ layer (GO:0060795)3.93423544
71pyrimidine ribonucleoside catabolic process (GO:0046133)3.88200505
72protein deneddylation (GO:0000338)3.85555211
73pseudouridine synthesis (GO:0001522)3.85079759
74respiratory electron transport chain (GO:0022904)3.81270696
75cardiovascular system development (GO:0072358)3.78365589
76electron transport chain (GO:0022900)3.78095450
77DNA damage response, detection of DNA damage (GO:0042769)3.76145718
78epoxygenase P450 pathway (GO:0019373)3.74845935
79regulation of telomerase activity (GO:0051972)3.68620640
80mitochondrion distribution (GO:0048311)3.68317055
81microtubule severing (GO:0051013)3.67287903
82chromatin assembly (GO:0031497)3.67154688
83biotin metabolic process (GO:0006768)3.66729448
84intestinal epithelial cell development (GO:0060576)3.66082757
85transepithelial transport (GO:0070633)3.63296367
86transcription from mitochondrial promoter (GO:0006390)3.61909770
87GDP-mannose metabolic process (GO:0019673)3.58913790
88proline transport (GO:0015824)3.58154072
89termination of RNA polymerase III transcription (GO:0006386)3.57497679
90transcription elongation from RNA polymerase III promoter (GO:0006385)3.57497679
91negative regulation of potassium ion transmembrane transport (GO:1901380)3.57389171
92regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.53441039
93response to pheromone (GO:0019236)3.52584648
94sister chromatid segregation (GO:0000819)3.52561654
95maintenance of protein localization in organelle (GO:0072595)3.51907692
96arachidonic acid secretion (GO:0050482)3.51239056
97icosanoid secretion (GO:0032309)3.51239056
98ribosome biogenesis (GO:0042254)3.41928248
99intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.36543532
100omega-hydroxylase P450 pathway (GO:0097267)3.35679222
101intracellular protein transmembrane import (GO:0044743)3.34023565
102retinoic acid receptor signaling pathway (GO:0048384)3.30660285
103positive regulation of protein deacetylation (GO:0090312)3.28077896
104protein polyglutamylation (GO:0018095)3.25121971
105detection of temperature stimulus (GO:0016048)3.24274083
106negative regulation of interleukin-2 production (GO:0032703)3.23111887
107proteasome assembly (GO:0043248)3.22316403
108regulation of microtubule-based movement (GO:0060632)3.21757083
109regulation of telomere maintenance (GO:0032204)3.18070072
110calcium-mediated signaling using intracellular calcium source (GO:0035584)3.13956294
111cell wall macromolecule catabolic process (GO:0016998)3.13467662
112protein-cofactor linkage (GO:0018065)3.12657419
113positive regulation of digestive system process (GO:0060456)3.12656850
114negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.10775372
115viral transcription (GO:0019083)3.10093841
116trophectodermal cell differentiation (GO:0001829)3.08882820
117translational termination (GO:0006415)3.08594717
118behavioral response to nicotine (GO:0035095)3.07469667
119nuclear pore complex assembly (GO:0051292)3.07059794
120primary alcohol catabolic process (GO:0034310)3.04773912
121ribosomal small subunit assembly (GO:0000028)3.01363355
122positive regulation of gluconeogenesis (GO:0045722)3.00916279
123cotranslational protein targeting to membrane (GO:0006613)3.00020501
124ribosomal small subunit biogenesis (GO:0042274)2.99698651
125SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.98960772
126bone trabecula formation (GO:0060346)2.98439399
127translational elongation (GO:0006414)2.98398859
128apoptotic DNA fragmentation (GO:0006309)2.96076351
129formation of translation preinitiation complex (GO:0001731)2.95670053
130platelet dense granule organization (GO:0060155)2.94122085
131mitochondrial DNA replication (GO:0006264)2.94073112
132ATP biosynthetic process (GO:0006754)2.93491425
133cellular component biogenesis (GO:0044085)2.93204069
134vitamin A metabolic process (GO:0006776)2.93197367
135protein targeting to ER (GO:0045047)2.92347632
136translation (GO:0006412)2.92000189
137regulation of gene silencing by miRNA (GO:0060964)2.91947565
138regulation of gene silencing by RNA (GO:0060966)2.91947565
139preassembly of GPI anchor in ER membrane (GO:0016254)2.88377413
140hydrogen ion transmembrane transport (GO:1902600)2.86691262
141negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82881329
142tRNA processing (GO:0008033)2.80750670
143chromatin remodeling at centromere (GO:0031055)2.80600971
144protein localization to endoplasmic reticulum (GO:0070972)2.79623099
145purine nucleoside triphosphate biosynthetic process (GO:0009145)2.79601242
146aerobic respiration (GO:0009060)2.76956065
147establishment of protein localization to endoplasmic reticulum (GO:0072599)2.76825063
148peptidyl-histidine modification (GO:0018202)2.76817071
149regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.76365357
150regulation of mitotic spindle checkpoint (GO:1903504)2.76365357
151histone H2A acetylation (GO:0043968)2.75270993
152L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74619765
153purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.73795787
154maturation of 5.8S rRNA (GO:0000460)2.72520474
155proton transport (GO:0015992)2.70875314
156mitochondrion morphogenesis (GO:0070584)2.70386364
157cell wall macromolecule metabolic process (GO:0044036)2.70218954
158protein targeting to mitochondrion (GO:0006626)2.69067175
159hydrogen transport (GO:0006818)2.67770851
160peroxisome fission (GO:0016559)2.66511982
161DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.66398260
162RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66153926
163piRNA metabolic process (GO:0034587)2.65283219
164CENP-A containing nucleosome assembly (GO:0034080)2.65026605
165somatic diversification of immune receptors via somatic mutation (GO:0002566)2.62406717
166somatic hypermutation of immunoglobulin genes (GO:0016446)2.62406717
167positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62252509
168replication fork processing (GO:0031297)2.61762656
169ribosomal large subunit biogenesis (GO:0042273)2.61058468
170establishment of protein localization to mitochondrion (GO:0072655)2.61003822
171signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.59323918
172signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.59323918
173signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.59323918
174regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.59105943
175otic vesicle formation (GO:0030916)2.56494558
176rRNA processing (GO:0006364)2.55561655
177fucose catabolic process (GO:0019317)2.55088441
178L-fucose metabolic process (GO:0042354)2.55088441
179L-fucose catabolic process (GO:0042355)2.55088441
180mannosylation (GO:0097502)2.54887616
181rRNA metabolic process (GO:0016072)2.54190035
182signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.54136920
183intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.54136920
184negative regulation of membrane potential (GO:0045837)2.53836828
185pantothenate metabolic process (GO:0015939)2.52319994
186L-methionine salvage (GO:0071267)2.50433524
187L-methionine biosynthetic process (GO:0071265)2.50433524
188amino acid salvage (GO:0043102)2.50433524
189serine family amino acid catabolic process (GO:0009071)2.48632688
190polyketide metabolic process (GO:0030638)12.3479773
191doxorubicin metabolic process (GO:0044598)12.3479773
192daunorubicin metabolic process (GO:0044597)12.3479773

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.90973975
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.90973975
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.90973975
4BP1_19119308_ChIP-ChIP_Hs578T_Human6.64527380
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.55803230
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.33573562
7GABP_17652178_ChIP-ChIP_JURKAT_Human4.16853830
8E2F7_22180533_ChIP-Seq_HELA_Human3.40821364
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.38457034
10ZNF274_21170338_ChIP-Seq_K562_Hela3.24279158
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.93816682
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.93755210
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.92723377
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.79669380
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59561497
16VDR_22108803_ChIP-Seq_LS180_Human2.53709803
17* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.50009255
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.49989720
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.49831075
20ELK1_19687146_ChIP-ChIP_HELA_Human2.42679010
21* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.41415824
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40414339
23VDR_23849224_ChIP-Seq_CD4+_Human2.40111699
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37953923
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34749757
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22341671
27NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.20902831
28FUS_26573619_Chip-Seq_HEK293_Human2.18852671
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11680659
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08114768
31* SRF_21415370_ChIP-Seq_HL-1_Mouse2.02590499
32NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.00429179
33EWS_26573619_Chip-Seq_HEK293_Human1.97986140
34NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.97979988
35IGF1R_20145208_ChIP-Seq_DFB_Human1.94048741
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.94039028
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.93380477
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92864551
39MYC_18940864_ChIP-ChIP_HL60_Human1.85845909
40IRF1_19129219_ChIP-ChIP_H3396_Human1.80289178
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.79407197
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76837294
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73633781
44ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.72391811
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72248431
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72207858
47POU5F1_16518401_ChIP-PET_MESCs_Mouse1.70560419
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68762331
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67316211
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66408145
51P300_19829295_ChIP-Seq_ESCs_Human1.65818676
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65277264
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62965284
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.61388093
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57300830
56TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.56721164
57TAF15_26573619_Chip-Seq_HEK293_Human1.54402539
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54101487
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53799001
60* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52704047
61GBX2_23144817_ChIP-Seq_PC3_Human1.50194195
62* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.49209316
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47216545
64* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46259034
65* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44905988
66* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.44245615
67* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.44194124
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43062123
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42587385
70E2F1_17053090_ChIP-ChIP_MCF-7_Human1.41713820
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41633268
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41029328
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39608893
74* YY1_21170310_ChIP-Seq_MESCs_Mouse1.38560854
75PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.37968342
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36802830
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.33977647
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32921912
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31921764
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29114032
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28808080
82* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.28225601
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27755839
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27505712
85* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27174591
86TP53_22573176_ChIP-Seq_HFKS_Human1.26415726
87CDX2_20551321_ChIP-Seq_CACO-2_Human1.26271904
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.24474701
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23597724
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23269999
91GABP_19822575_ChIP-Seq_HepG2_Human1.20391344
92NANOG_19829295_ChIP-Seq_ESCs_Human1.19885358
93SOX2_19829295_ChIP-Seq_ESCs_Human1.19885358
94* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19523329
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18974907
96* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.18830396
97* NANOG_16518401_ChIP-PET_MESCs_Mouse1.16522361
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12655978
99HTT_18923047_ChIP-ChIP_STHdh_Human1.12530646
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11544518
101AR_20517297_ChIP-Seq_VCAP_Human1.11454018
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11291147
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10486674
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.08736207
105FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08736207
106DCP1A_22483619_ChIP-Seq_HELA_Human1.08644180
107TTF2_22483619_ChIP-Seq_HELA_Human1.07839351
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07732078
109ER_23166858_ChIP-Seq_MCF-7_Human1.07250512
110HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05234973
111NANOG_16153702_ChIP-ChIP_HESCs_Human1.05212454
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.05197830
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04538809
114BCAT_22108803_ChIP-Seq_LS180_Human1.03465458
115NCOR_22424771_ChIP-Seq_293T_Human1.02968526
116CBP_20019798_ChIP-Seq_JUKART_Human1.02589722
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02589722
118EST1_17652178_ChIP-ChIP_JURKAT_Human1.01745726
119RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00890957
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99848717
121THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98919851
122PHF8_20622853_ChIP-Seq_HELA_Human0.98217675
123BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97952757
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.97267540
125EZH2_22144423_ChIP-Seq_EOC_Human0.96162576
126* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96009802
127EZH2_27294783_Chip-Seq_NPCs_Mouse0.94776659
128ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94707031
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94351347
130RBPJ_21746931_ChIP-Seq_IB4_Human0.93293963
131NFE2_27457419_Chip-Seq_LIVER_Mouse0.92995316
132STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92873304
133* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92281781
134FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92027786
135AR_25329375_ChIP-Seq_VCAP_Human0.91228032
136AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91177642
137PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90811270
138POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90689840
139ETV1_20927104_ChIP-Seq_GIST48_Human0.90550461
140ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89807197
141TP53_22127205_ChIP-Seq_IMR90_Human0.89585234
142KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89408891
143* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89161418
144GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88675743
145TCF4_22108803_ChIP-Seq_LS180_Human0.88672535
146CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88306259
147* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87369190
148GATA3_21878914_ChIP-Seq_MCF-7_Human0.86626391
149HOXB7_26014856_ChIP-Seq_BT474_Human0.86367540
150FOXP3_21729870_ChIP-Seq_TREG_Human0.80478561
151SMC4_20622854_ChIP-Seq_HELA_Human0.79842320
152SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77944251
153TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.77157619
154SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77018604
155CTCF_21964334_Chip-Seq_Bcells_Human0.76614607
156ETS1_20019798_ChIP-Seq_JURKAT_Human0.76189104
157SCL_19346495_ChIP-Seq_HPC-7_Human0.75222717
158TBX3_20139965_ChIP-Seq_ESCs_Mouse0.75146996
159NCOR1_26117541_ChIP-Seq_K562_Human0.74082358
160TBX3_20139965_ChIP-Seq_MESCs_Mouse0.73673848
161* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.73642959
162ELK1_22589737_ChIP-Seq_MCF10A_Human0.73059312
163SOX2_16153702_ChIP-ChIP_HESCs_Human0.72503764
164ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.71057221
165KLF4_18555785_ChIP-Seq_MESCs_Mouse0.70805605
166* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.69937934
167HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.69393080
168RNF2_27304074_Chip-Seq_NSC_Mouse0.68278195
169EOMES_21245162_ChIP-Seq_HESCs_Human0.68096714
170KAP1_27257070_Chip-Seq_ESCs_Mouse0.67370538
171ESET_19884257_ChIP-Seq_ESCs_Mouse0.67039058
172ELF1_20517297_ChIP-Seq_JURKAT_Human0.66579202
173CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.66127219
174SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.65986592
175SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.64372107
176KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.64031995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.37408392
2MP0002254_reproductive_system_inflammat4.60666638
3MP0006292_abnormal_olfactory_placode4.44760423
4MP0004264_abnormal_extraembryonic_tissu4.05854176
5MP0005394_taste/olfaction_phenotype3.66449291
6MP0005499_abnormal_olfactory_system3.66449291
7MP0005075_abnormal_melanosome_morpholog3.40230272
8MP0002638_abnormal_pupillary_reflex3.31087335
9MP0003890_abnormal_embryonic-extraembry3.29421230
10MP0004858_abnormal_nervous_system3.17655712
11MP0002332_abnormal_exercise_endurance3.12124334
12MP0006072_abnormal_retinal_apoptosis3.06240681
13MP0003646_muscle_fatigue2.93269809
14MP0006035_abnormal_mitochondrial_morpho2.83384035
15MP0008877_abnormal_DNA_methylation2.76936211
16MP0003122_maternal_imprinting2.73664799
17MP0004957_abnormal_blastocyst_morpholog2.73020733
18MP0002102_abnormal_ear_morphology2.65996235
19MP0008057_abnormal_DNA_replication2.50508096
20MP0002837_dystrophic_cardiac_calcinosis2.43517064
21MP0000372_irregular_coat_pigmentation2.35372566
22MP0008058_abnormal_DNA_repair2.20905739
23MP0005257_abnormal_intraocular_pressure2.18274121
24MP0003718_maternal_effect2.17007409
25MP0002938_white_spotting2.15055628
26MP0003195_calcinosis2.04466308
27MP0002127_abnormal_cardiovascular_syste2.02902212
28MP0000678_abnormal_parathyroid_gland2.02445714
29MP0005551_abnormal_eye_electrophysiolog1.99778758
30MP0003121_genomic_imprinting1.98298393
31MP0003938_abnormal_ear_development1.97709106
32MP0003787_abnormal_imprinting1.93389942
33MP0002277_abnormal_respiratory_mucosa1.89394673
34MP0001529_abnormal_vocalization1.85843131
35MP0003705_abnormal_hypodermis_morpholog1.84722491
36MP0001986_abnormal_taste_sensitivity1.83505711
37MP0002653_abnormal_ependyma_morphology1.81572550
38MP0009379_abnormal_foot_pigmentation1.72892974
39MP0004142_abnormal_muscle_tone1.71866104
40MP0004043_abnormal_pH_regulation1.71574048
41MP0008961_abnormal_basal_metabolism1.71387652
42MP0000762_abnormal_tongue_morphology1.71128589
43MP0003186_abnormal_redox_activity1.68463163
44MP0008875_abnormal_xenobiotic_pharmacok1.68143694
45MP0005084_abnormal_gallbladder_morpholo1.67179078
46MP0005646_abnormal_pituitary_gland1.62296457
47MP0003137_abnormal_impulse_conducting1.61673296
48* MP0005380_embryogenesis_phenotype1.59234091
49* MP0001672_abnormal_embryogenesis/_devel1.59234091
50MP0010352_gastrointestinal_tract_polyps1.58435860
51MP0001968_abnormal_touch/_nociception1.56667343
52MP0008789_abnormal_olfactory_epithelium1.53838765
53MP0003183_abnormal_peptide_metabolism1.51721900
54MP0004381_abnormal_hair_follicle1.51608193
55MP0001984_abnormal_olfaction1.51477488
56MP0000049_abnormal_middle_ear1.47725437
57MP0001485_abnormal_pinna_reflex1.46628117
58MP0000750_abnormal_muscle_regeneration1.46168696
59MP0000749_muscle_degeneration1.45950162
60MP0003880_abnormal_central_pattern1.44918057
61MP0002160_abnormal_reproductive_system1.44627758
62* MP0002088_abnormal_embryonic_growth/wei1.43566935
63MP0005266_abnormal_metabolism1.42738233
64* MP0003984_embryonic_growth_retardation1.42426574
65MP0002736_abnormal_nociception_after1.41405561
66MP0010030_abnormal_orbit_morphology1.39802419
67MP0005379_endocrine/exocrine_gland_phen1.38914570
68MP0002163_abnormal_gland_morphology1.38701531
69MP0003123_paternal_imprinting1.38659984
70MP0003693_abnormal_embryo_hatching1.37967640
71MP0001764_abnormal_homeostasis1.30302508
72MP0002932_abnormal_joint_morphology1.29769344
73MP0002876_abnormal_thyroid_physiology1.29516968
74MP0002272_abnormal_nervous_system1.29095166
75MP0005389_reproductive_system_phenotype1.28770011
76MP0006036_abnormal_mitochondrial_physio1.28234089
77MP0004147_increased_porphyrin_level1.27558408
78MP0009745_abnormal_behavioral_response1.27464626
79MP0002269_muscular_atrophy1.25447096
80MP0009046_muscle_twitch1.25401637
81MP0002233_abnormal_nose_morphology1.25166910
82MP0008995_early_reproductive_senescence1.21758121
83MP0004145_abnormal_muscle_electrophysio1.19902326
84MP0005174_abnormal_tail_pigmentation1.19394881
85MP0001293_anophthalmia1.18041016
86MP0003567_abnormal_fetal_cardiomyocyte1.16931440
87MP0002092_abnormal_eye_morphology1.13232852
88MP0000631_abnormal_neuroendocrine_gland1.12320774
89MP0000350_abnormal_cell_proliferation1.11042189
90MP0001905_abnormal_dopamine_level1.10366519
91MP0002970_abnormal_white_adipose1.07329191
92MP0005195_abnormal_posterior_eye1.07328028
93MP0001849_ear_inflammation1.06749739
94MP0005645_abnormal_hypothalamus_physiol1.06506470
95MP0001501_abnormal_sleep_pattern1.06056965
96MP0002114_abnormal_axial_skeleton1.05408777
97MP0002085_abnormal_embryonic_tissue1.05302740
98MP0002095_abnormal_skin_pigmentation1.03838832
99MP0003315_abnormal_perineum_morphology1.03397361
100MP0003077_abnormal_cell_cycle1.02979912
101MP0002210_abnormal_sex_determination1.02076939
102MP0002086_abnormal_extraembryonic_tissu1.01721593
103MP0006082_CNS_inflammation0.98667915
104MP0003136_yellow_coat_color0.96466338
105MP0005330_cardiomyopathy0.96023104
106MP0001348_abnormal_lacrimal_gland0.95915280
107MP0001929_abnormal_gametogenesis0.94718532
108MP0001919_abnormal_reproductive_system0.94473330
109MP0002396_abnormal_hematopoietic_system0.93723361
110MP0003755_abnormal_palate_morphology0.93622052
111MP0003950_abnormal_plasma_membrane0.92430032
112MP0000428_abnormal_craniofacial_morphol0.92378943
113MP0002249_abnormal_larynx_morphology0.92045342
114MP0006276_abnormal_autonomic_nervous0.91928322
115MP0005332_abnormal_amino_acid0.91473339
116MP0002234_abnormal_pharynx_morphology0.91341631
117MP0004885_abnormal_endolymph0.91141136
118MP0001324_abnormal_eye_pigmentation0.88840377
119MP0004742_abnormal_vestibular_system0.87505536
120MP0000653_abnormal_sex_gland0.87084479
121MP0001486_abnormal_startle_reflex0.86470689
122MP0003119_abnormal_digestive_system0.86419128
123MP0003878_abnormal_ear_physiology0.86187586
124MP0005377_hearing/vestibular/ear_phenot0.86187586
125MP0001145_abnormal_male_reproductive0.85307196
126MP0004215_abnormal_myocardial_fiber0.84769681
127MP0004133_heterotaxia0.84648706
128MP0002098_abnormal_vibrissa_morphology0.84643957
129MP0002084_abnormal_developmental_patter0.84104324
130MP0003111_abnormal_nucleus_morphology0.83953774
131MP0000432_abnormal_head_morphology0.83449820
132MP0005410_abnormal_fertilization0.83333326
133MP0002572_abnormal_emotion/affect_behav0.83249446
134MP0000647_abnormal_sebaceous_gland0.83014751
135MP0005423_abnormal_somatic_nervous0.82735838
136MP0008770_decreased_survivor_rate0.82448964
137MP0002557_abnormal_social/conspecific_i0.81628987
138MP0005391_vision/eye_phenotype0.81049960
139MP0003698_abnormal_male_reproductive0.80233570
140MP0002132_abnormal_respiratory_system0.80041591
141MP0000759_abnormal_skeletal_muscle0.79871945
142MP0002796_impaired_skin_barrier0.79118658
143MP0002752_abnormal_somatic_nervous0.78669441
144MP0010094_abnormal_chromosome_stability0.78040363
145MP0003935_abnormal_craniofacial_develop0.77181168
146MP0005671_abnormal_response_to0.76746119
147MP0001119_abnormal_female_reproductive0.76126130
148MP0009764_decreased_sensitivity_to0.73118054
149MP0001730_embryonic_growth_arrest0.72472847
150MP0002734_abnormal_mechanical_nocicepti0.71894009
151MP0008932_abnormal_embryonic_tissue0.71480019
152MP0005508_abnormal_skeleton_morphology0.70241917
153MP0002751_abnormal_autonomic_nervous0.69945230
154MP0005248_abnormal_Harderian_gland0.68861200
155MP0004085_abnormal_heartbeat0.67938061
156MP0009115_abnormal_fat_cell0.66108200
157MP0000313_abnormal_cell_death0.65616484
158MP0004084_abnormal_cardiac_muscle0.64850586
159MP0000358_abnormal_cell_content/0.64372077
160MP0001697_abnormal_embryo_size0.63398899
161MP0003786_premature_aging0.63169697
162MP0003937_abnormal_limbs/digits/tail_de0.61824599
163MP0008872_abnormal_physiological_respon0.61535502
164MP0005253_abnormal_eye_physiology0.61118998
165MP0004087_abnormal_muscle_fiber0.60755556
166MP0002925_abnormal_cardiovascular_devel0.60547780
167MP0004197_abnormal_fetal_growth/weight/0.58274490
168MP0002116_abnormal_craniofacial_bone0.58015905
169MP0010630_abnormal_cardiac_muscle0.57862429
170* MP0002080_prenatal_lethality0.57261191
171MP0000383_abnormal_hair_follicle0.57205719
172MP0000490_abnormal_crypts_of0.57205682
173MP0003806_abnormal_nucleotide_metabolis0.56956389

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.52274810
2Hypochromic microcytic anemia (HP:0004840)5.69547257
3Multiple enchondromatosis (HP:0005701)5.64385359
4Hepatoblastoma (HP:0002884)5.10197600
5Rib fusion (HP:0000902)4.66110163
6Testicular atrophy (HP:0000029)4.48995732
7Abnormality of the lower motor neuron (HP:0002366)4.42119901
8Mitochondrial inheritance (HP:0001427)3.99237644
9Increased hepatocellular lipid droplets (HP:0006565)3.97687283
10Ependymoma (HP:0002888)3.95704585
11Lipid accumulation in hepatocytes (HP:0006561)3.88377933
12Acute necrotizing encephalopathy (HP:0006965)3.86520899
13Increased CSF lactate (HP:0002490)3.86441185
14Ragged-red muscle fibers (HP:0003200)3.84757433
15Methylmalonic acidemia (HP:0002912)3.82721319
16Neoplasm of striated muscle (HP:0009728)3.75623040
17Hepatocellular necrosis (HP:0001404)3.74454943
18Partial duplication of thumb phalanx (HP:0009944)3.70501456
19Hepatic necrosis (HP:0002605)3.56067871
20Nephroblastoma (Wilms tumor) (HP:0002667)3.52835033
21Rhabdomyosarcoma (HP:0002859)3.50863544
22Aplasia/Hypoplasia of the fovea (HP:0008060)3.47133792
23Hypoplasia of the fovea (HP:0007750)3.47133792
24Bifid tongue (HP:0010297)3.44719600
25Hyperinsulinemic hypoglycemia (HP:0000825)3.42494224
26Hyperglycinemia (HP:0002154)3.42340685
27Acute encephalopathy (HP:0006846)3.37788854
28Abnormal mitochondria in muscle tissue (HP:0008316)3.34979611
29Rectal fistula (HP:0100590)3.34948240
30Rectovaginal fistula (HP:0000143)3.34948240
31Progressive macrocephaly (HP:0004481)3.34209653
32Chromosomal breakage induced by crosslinking agents (HP:0003221)3.30357673
33Anomalous pulmonary venous return (HP:0010772)3.25870198
34Embryonal renal neoplasm (HP:0011794)3.24366892
35Renal Fanconi syndrome (HP:0001994)3.23643806
36Pancreatic fibrosis (HP:0100732)3.22609190
37Pancreatic cysts (HP:0001737)3.20479943
38Abnormality of the salivary glands (HP:0010286)3.20467011
39Partial duplication of the phalanx of hand (HP:0009999)3.18139742
40Methylmalonic aciduria (HP:0012120)3.15084186
41Progressive muscle weakness (HP:0003323)3.10702148
42Abnormality of midbrain morphology (HP:0002418)3.09819159
43Molar tooth sign on MRI (HP:0002419)3.09819159
44Abnormal lung lobation (HP:0002101)3.02146138
45True hermaphroditism (HP:0010459)2.98612329
46Hypoplasia of the pons (HP:0012110)2.94360368
47Abnormality of cells of the erythroid lineage (HP:0012130)2.93519246
48Trismus (HP:0000211)2.93385369
49Vaginal fistula (HP:0004320)2.92433701
50Fused cervical vertebrae (HP:0002949)2.91991854
51Intestinal fistula (HP:0100819)2.90643646
52Hyperventilation (HP:0002883)2.88101517
53Global brain atrophy (HP:0002283)2.86525786
54Abnormal cartilage morphology (HP:0002763)2.86047361
55Difficulty running (HP:0009046)2.85797062
56Chromsome breakage (HP:0040012)2.84201036
57Abnormal number of erythroid precursors (HP:0012131)2.82423184
58Abnormality of the pons (HP:0007361)2.79836721
59Preauricular pit (HP:0004467)2.78706393
60Periauricular skin pits (HP:0100277)2.78706393
61Increased serum lactate (HP:0002151)2.74432596
62Abnormality of the pulmonary veins (HP:0011718)2.74066827
633-Methylglutaconic aciduria (HP:0003535)2.73963135
64Amyotrophic lateral sclerosis (HP:0007354)2.73687711
65Horizontal nystagmus (HP:0000666)2.73576795
66Tetraplegia (HP:0002445)2.71315324
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68594051
68Abnormality of alanine metabolism (HP:0010916)2.68594051
69Hyperalaninemia (HP:0003348)2.68594051
70Abnormality of the astrocytes (HP:0100707)2.65643508
71Astrocytoma (HP:0009592)2.65643508
72Sensory axonal neuropathy (HP:0003390)2.65581904
73Nasolacrimal duct obstruction (HP:0000579)2.64866190
74Increased intramyocellular lipid droplets (HP:0012240)2.61560259
75Aplasia/hypoplasia of the humerus (HP:0006507)2.58818062
76Abnormality of the fovea (HP:0000493)2.57695441
77Abnormality of glycolysis (HP:0004366)2.54902544
78Increased serum pyruvate (HP:0003542)2.54902544
79Medial flaring of the eyebrow (HP:0010747)2.53367301
80Reduced antithrombin III activity (HP:0001976)2.52164809
81Increased connective tissue (HP:0009025)2.52118682
82Exertional dyspnea (HP:0002875)2.52039420
83Progressive external ophthalmoplegia (HP:0000590)2.51663379
84Short humerus (HP:0005792)2.50963134
85Preauricular skin tag (HP:0000384)2.48664816
86Microvesicular hepatic steatosis (HP:0001414)2.48053593
87Impulsivity (HP:0100710)2.47869777
88Abnormality of serum amino acid levels (HP:0003112)2.47294707
89Generalized hypotonia (HP:0001290)2.44828504
90Cerebral edema (HP:0002181)2.43236798
91Lactic acidosis (HP:0003128)2.43137582
92Congenital, generalized hypertrichosis (HP:0004540)2.43120418
93Abnormality of glycine metabolism (HP:0010895)2.42292248
94Abnormality of serine family amino acid metabolism (HP:0010894)2.42292248
95Nephronophthisis (HP:0000090)2.42156365
96Colon cancer (HP:0003003)2.39790856
97Abnormality of chromosome segregation (HP:0002916)2.39295876
98Congenital stationary night blindness (HP:0007642)2.38693508
99Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37584192
100Hypochromic anemia (HP:0001931)2.36587461
101CNS demyelination (HP:0007305)2.35861256
102Premature ovarian failure (HP:0008209)2.35343584
103Dyskinesia (HP:0100660)2.34673144
104Abnormality of small intestinal villus morphology (HP:0011472)2.30683328
105Villous atrophy (HP:0011473)2.30683328
106Sclerocornea (HP:0000647)2.30374699
107Shawl scrotum (HP:0000049)2.28284481
108Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26725181
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.25747923
110Increased muscle lipid content (HP:0009058)2.25255051
111Tongue fasciculations (HP:0001308)2.25187138
112Aplasia/Hypoplasia of the macula (HP:0008059)2.23002828
113Malnutrition (HP:0004395)2.22727504
114Optic disc pallor (HP:0000543)2.22691443
115Hyperglycinuria (HP:0003108)2.22529033
116Abnormality of the vitamin B12 metabolism (HP:0004341)2.20437167
117Large earlobe (HP:0009748)2.20215108
118Stenosis of the external auditory canal (HP:0000402)2.19952423
119Skin pits (HP:0100276)2.19856015
120Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.19139569
121Abnormality of urine glucose concentration (HP:0011016)2.19041198
122Glycosuria (HP:0003076)2.19041198
123Abnormality of vitamin B metabolism (HP:0004340)2.19008933
124Neurodegeneration (HP:0002180)2.18897005
125Abnormality of the phalanges of the hallux (HP:0010057)2.18892679
126Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18834455
127Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18834455
128Microretrognathia (HP:0000308)2.17309115
129Hypobetalipoproteinemia (HP:0003563)2.16008760
130Abolished electroretinogram (ERG) (HP:0000550)2.14728236
131Muscle fibrillation (HP:0010546)2.13817695
132Supernumerary spleens (HP:0009799)2.13422596
133Ventricular tachycardia (HP:0004756)2.13396347
134Skin tags (HP:0010609)2.12217813
135Respiratory failure (HP:0002878)2.11987865
136Concave nail (HP:0001598)2.10119071
137Abnormality of the pubic bones (HP:0003172)2.08415055
138Septo-optic dysplasia (HP:0100842)2.08094452
139Respiratory difficulties (HP:0002880)2.07719403
140Cheilitis (HP:0100825)2.07119568
141Aplasia/Hypoplasia affecting the retina (HP:0008061)2.07029795
142Abnormality of renal resorption (HP:0011038)2.06372896
143Abnormality of the musculature of the hand (HP:0001421)2.05907617
144Lethargy (HP:0001254)2.05862715
145Delayed CNS myelination (HP:0002188)2.05182635
146Upper limb muscle weakness (HP:0003484)2.04604966
147Neoplasm of the heart (HP:0100544)2.04078402
148Exercise-induced muscle cramps (HP:0003710)2.04035777
149Abnormality of the phalanges of the 2nd finger (HP:0009541)2.03048118
150Aplasia/Hypoplasia of the sternum (HP:0006714)2.03020266
151Congenital primary aphakia (HP:0007707)2.02789397
152Pseudobulbar signs (HP:0002200)2.02098137
153Abnormality of the labia minora (HP:0012880)1.99630915
154Gait imbalance (HP:0002141)1.99404193
155Abnormality of the lacrimal duct (HP:0011481)1.97650180
156Abnormal biliary tract physiology (HP:0012439)1.97328637
157Bile duct proliferation (HP:0001408)1.97328637
158Meckel diverticulum (HP:0002245)1.96968227
159Brushfield spots (HP:0001088)1.96844225
160Glossoptosis (HP:0000162)1.96708138
161Fasciculations (HP:0002380)1.93979110
162Exercise intolerance (HP:0003546)1.93781691
163Duplication of thumb phalanx (HP:0009942)1.93764427
164Hypopigmentation of the fundus (HP:0007894)1.93140657
165Abnormality of the renal medulla (HP:0100957)1.92782376
166Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92486876
167Chronic hepatic failure (HP:0100626)1.91794958
168Glioma (HP:0009733)1.90306771
169Hypoplastic scapulae (HP:0000882)1.89651313
170Aplasia/Hypoplasia of the scapulae (HP:0006713)1.89651313
171Hemiparesis (HP:0001269)1.89565737
172Malignant neoplasm of the central nervous system (HP:0100836)1.89535587
173Tubulointerstitial nephritis (HP:0001970)1.89427755
174Macrocytic anemia (HP:0001972)1.87518944
175Ketoacidosis (HP:0001993)1.86504962
176Carpal bone hypoplasia (HP:0001498)1.86065054
177Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85455624
178Dicarboxylic aciduria (HP:0003215)1.85455624
179Type II lissencephaly (HP:0007260)1.85443967
180Nephrogenic diabetes insipidus (HP:0009806)1.84794076
181Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.84771753
182Patent foramen ovale (HP:0001655)1.83970357
183Abnormality of methionine metabolism (HP:0010901)1.83190153
184Aplasia/Hypoplasia of the tongue (HP:0010295)1.82352261
185Generalized aminoaciduria (HP:0002909)1.81739196
186Renal cortical cysts (HP:0000803)1.79890032
187Poor head control (HP:0002421)1.77436682
188Aplasia/hypoplasia of the uterus (HP:0008684)1.76299755
189Abnormality of the renal cortex (HP:0011035)1.76267012
190Leukodystrophy (HP:0002415)1.75794520
191Cystic liver disease (HP:0006706)1.70846757
192Type I transferrin isoform profile (HP:0003642)1.70616244
193Poor suck (HP:0002033)1.70354175
194Attenuation of retinal blood vessels (HP:0007843)1.69363338
195Decreased muscle mass (HP:0003199)1.67128292
196Genital tract atresia (HP:0001827)1.65095999
197Abnormal glycosylation (HP:0012345)1.62475605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.24548550
2GRK55.68572500
3GRK64.40654832
4ERN14.03560994
5GRK13.39540424
6ADRBK23.34245283
7FRK3.14780459
8MAP4K23.05581042
9VRK22.91172305
10GRK72.90056092
11ZAK2.86998877
12TTK2.81157281
13STK162.71915855
14CSF1R2.69615455
15MAPK72.55635474
16TGFBR22.54582203
17NUAK12.53142115
18TYRO32.49969809
19BMPR1B2.47986583
20WNK32.44160539
21MOS2.39843421
22INSRR2.29012229
23TLK12.15647413
24WNK12.14590840
25MATK2.09657801
26STK102.06701310
27VRK12.05044218
28EIF2AK32.03811744
29MST41.91644948
30PINK11.90180487
31CAMK41.49553650
32TXK1.47738399
33PRKG21.44339146
34NTRK11.43906200
35CASK1.43744055
36CDK71.43019063
37PLK31.38846295
38MAP2K41.38625251
39ACVR1B1.38003937
40MARK21.37868062
41TRIM281.34404548
42TGFBR11.34402877
43BRSK21.34175898
44TNIK1.33031064
45MKNK21.31361979
46ADRBK11.29606055
47TAF11.27719272
48TSSK61.25050554
49EPHA21.21341716
50MAP3K41.19237565
51SRPK11.17682726
52CHEK21.14368314
53MAPK121.09307791
54MAP2K61.08173144
55PLK11.07777983
56MKNK11.06841986
57PBK1.06240851
58HIPK21.05677779
59CSNK1G11.00621744
60MAPKAPK31.00522025
61PLK40.98908630
62OXSR10.98770012
63AKT30.97889907
64PASK0.96480062
65CSNK1G30.95755924
66CSNK1G20.94058649
67WNK40.92664945
68MAP3K70.90473806
69MAPKAPK50.90238077
70STK390.89046512
71MAPK130.87717469
72AKT20.87327117
73MAP2K70.83736845
74PAK40.83028567
75ERBB30.82521567
76PDK40.78121356
77PDK30.78121356
78TIE10.76790285
79PKN10.74904820
80FGFR30.74123257
81PLK20.71533589
82MUSK0.70748394
83PRKCE0.69979104
84CSNK1A1L0.67076895
85RPS6KA50.66267152
86DYRK30.66046956
87BUB10.65896716
88MAP3K100.65774257
89CHEK10.64929360
90LATS20.63978138
91STK30.63363267
92PNCK0.63226364
93STK38L0.62845349
94TAOK30.61367579
95ATR0.60471632
96NME20.57663336
97MAP3K90.56147058
98ABL20.55573720
99AURKA0.54617010
100PIM10.51657829
101FGFR20.50514657
102BCKDK0.48289561
103CAMK2A0.48204403
104PRKCQ0.47536529
105CSNK2A10.47329811
106RPS6KB20.47142140
107EIF2AK10.47094072
108ALK0.44651531
109NEK20.44633405
110LMTK20.43941380
111NME10.43215899
112CSK0.42049902
113EIF2AK20.41752549
114TEC0.41488011
115CSNK1A10.40464266
116CSNK2A20.40399985
117MTOR0.40303460
118PRKCI0.39016341
119BCR0.38911946
120IGF1R0.38599934
121STK240.38045451
122TAOK20.37919556
123CDK20.35663086
124MAPK150.35488224
125MARK30.35161013
126WEE10.35151813
127LIMK10.35143058
128PIM20.34722024
129PDK20.34231721
130CSNK1E0.34229061
131CDK40.34136700
132NEK10.33064378
133CCNB10.33056992
134AURKB0.30095128
135MAPK100.29843541
136PRKCD0.28612510
137CDC70.28135507
138MAPK40.27925910
139PRKD20.27109034
140ITK0.25090851
141PRKCG0.24599975
142TNK20.23368854
143PRKACA0.23074483
144PAK10.23020930
145DYRK1A0.21460487
146ATM0.21323184
147TAOK10.20794321
148PRKACG0.20508438
149PRKAA10.19358407
150CDK10.19348138
151PRKACB0.18581833
152ERBB20.18525264
153EPHA40.17053268
154GSK3B0.16167936
155OBSCN0.15801753
156PHKG10.15257648
157PHKG20.15257648
158DYRK20.15050135
159PAK30.13436616
160STK380.12268345
161CDK190.12099832
162CDK150.11787511
163INSR0.11704911
164MAPK140.10828345
165CDK11A0.10685282
166MAPK10.10554140
167PTK20.10548990
168IKBKB0.10003156
169RPS6KA30.09353676
170PRKAA20.08632578
171CDK180.07854585
172TTN0.07819229

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.04549339
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.76221046
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.05216955
4Fructose and mannose metabolism_Homo sapiens_hsa000513.66797006
5Proteasome_Homo sapiens_hsa030503.13370414
6Protein export_Homo sapiens_hsa030602.82836213
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.79562913
8Arachidonic acid metabolism_Homo sapiens_hsa005902.57063197
9Galactose metabolism_Homo sapiens_hsa000522.53958361
10Linoleic acid metabolism_Homo sapiens_hsa005912.34246163
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.20536932
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.10372490
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00300157
14Ribosome_Homo sapiens_hsa030101.90642095
15Sulfur metabolism_Homo sapiens_hsa009201.84084304
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83768792
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.83411391
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82709554
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68687315
20Phototransduction_Homo sapiens_hsa047441.50055002
21Selenocompound metabolism_Homo sapiens_hsa004501.41914008
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40918738
23RNA transport_Homo sapiens_hsa030131.39548149
24Butanoate metabolism_Homo sapiens_hsa006501.36926107
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36209308
26Chemical carcinogenesis_Homo sapiens_hsa052041.36178271
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29782397
28RNA polymerase_Homo sapiens_hsa030201.27520846
29Cardiac muscle contraction_Homo sapiens_hsa042601.23488270
30Carbon metabolism_Homo sapiens_hsa012001.22975477
31Thyroid cancer_Homo sapiens_hsa052161.22325922
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20771067
33Purine metabolism_Homo sapiens_hsa002301.18069172
34Nucleotide excision repair_Homo sapiens_hsa034201.11914979
35Ether lipid metabolism_Homo sapiens_hsa005651.11691058
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10478746
37Folate biosynthesis_Homo sapiens_hsa007901.08885419
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.03678208
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01558758
40Sulfur relay system_Homo sapiens_hsa041221.00835500
41mTOR signaling pathway_Homo sapiens_hsa041501.00777138
42Base excision repair_Homo sapiens_hsa034100.99955876
43Fanconi anemia pathway_Homo sapiens_hsa034600.98629871
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96320088
45Oxidative phosphorylation_Homo sapiens_hsa001900.96239454
46Ovarian steroidogenesis_Homo sapiens_hsa049130.95751482
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95563918
48RNA degradation_Homo sapiens_hsa030180.95438338
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95050357
50mRNA surveillance pathway_Homo sapiens_hsa030150.93962380
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92336845
52Caffeine metabolism_Homo sapiens_hsa002320.91786021
53Homologous recombination_Homo sapiens_hsa034400.91722756
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91554506
55Pentose phosphate pathway_Homo sapiens_hsa000300.90644899
56Non-homologous end-joining_Homo sapiens_hsa034500.89858638
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.89799155
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87574614
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86909707
60beta-Alanine metabolism_Homo sapiens_hsa004100.82892334
61Propanoate metabolism_Homo sapiens_hsa006400.82484119
62Tryptophan metabolism_Homo sapiens_hsa003800.81205971
63Collecting duct acid secretion_Homo sapiens_hsa049660.80851519
64Regulation of autophagy_Homo sapiens_hsa041400.80241983
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79942032
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.79770736
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79138998
68Parkinsons disease_Homo sapiens_hsa050120.78949916
69Steroid biosynthesis_Homo sapiens_hsa001000.78417943
70Biosynthesis of amino acids_Homo sapiens_hsa012300.76298443
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75623526
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74914005
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.72221365
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.70894630
75Nicotine addiction_Homo sapiens_hsa050330.69939707
76Inositol phosphate metabolism_Homo sapiens_hsa005620.67934999
77Cell cycle_Homo sapiens_hsa041100.66794882
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66486353
79One carbon pool by folate_Homo sapiens_hsa006700.65630906
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65456854
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.63500681
82Asthma_Homo sapiens_hsa053100.63163596
83Huntingtons disease_Homo sapiens_hsa050160.63036991
84DNA replication_Homo sapiens_hsa030300.62307276
85Basal transcription factors_Homo sapiens_hsa030220.61921944
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.60565114
87Metabolic pathways_Homo sapiens_hsa011000.60560365
88Other glycan degradation_Homo sapiens_hsa005110.59729232
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56590097
90Fatty acid elongation_Homo sapiens_hsa000620.55843063
91Fatty acid degradation_Homo sapiens_hsa000710.55515913
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55335200
93PPAR signaling pathway_Homo sapiens_hsa033200.52221973
94Mismatch repair_Homo sapiens_hsa034300.52056404
95Type I diabetes mellitus_Homo sapiens_hsa049400.51573833
96Choline metabolism in cancer_Homo sapiens_hsa052310.50629083
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50317884
98Alzheimers disease_Homo sapiens_hsa050100.49552487
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.49363978
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49263876
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48132548
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47930952
103Allograft rejection_Homo sapiens_hsa053300.47325331
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47060721
105Basal cell carcinoma_Homo sapiens_hsa052170.46718326
106Fatty acid metabolism_Homo sapiens_hsa012120.46317459
107Fatty acid biosynthesis_Homo sapiens_hsa000610.45489391
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.45382536
109Olfactory transduction_Homo sapiens_hsa047400.45329712
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.45042248
111Rheumatoid arthritis_Homo sapiens_hsa053230.44935749
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.44727551
113Autoimmune thyroid disease_Homo sapiens_hsa053200.43018896
114Nitrogen metabolism_Homo sapiens_hsa009100.41870005
115Spliceosome_Homo sapiens_hsa030400.41264982
116Glutathione metabolism_Homo sapiens_hsa004800.39914509
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39657177
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39631996
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39604172
120Retinol metabolism_Homo sapiens_hsa008300.39462848
121Graft-versus-host disease_Homo sapiens_hsa053320.38988546
122Fat digestion and absorption_Homo sapiens_hsa049750.38595066
123Hedgehog signaling pathway_Homo sapiens_hsa043400.36785153
124Vitamin digestion and absorption_Homo sapiens_hsa049770.36430469
125Pyrimidine metabolism_Homo sapiens_hsa002400.35174997
126Taste transduction_Homo sapiens_hsa047420.34845440
127Glycerolipid metabolism_Homo sapiens_hsa005610.34483467
128Pathways in cancer_Homo sapiens_hsa052000.33973200
129Peroxisome_Homo sapiens_hsa041460.33847255
130Rap1 signaling pathway_Homo sapiens_hsa040150.33350422
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32503182
132Pyruvate metabolism_Homo sapiens_hsa006200.32418061
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32120464
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30371420
135AMPK signaling pathway_Homo sapiens_hsa041520.30184823
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30113389
137Dilated cardiomyopathy_Homo sapiens_hsa054140.28803385
138Arginine and proline metabolism_Homo sapiens_hsa003300.28317773
139Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26258142
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25910445
141Primary immunodeficiency_Homo sapiens_hsa053400.25751316
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24528008
143p53 signaling pathway_Homo sapiens_hsa041150.23767784
144Morphine addiction_Homo sapiens_hsa050320.23584903
145Starch and sucrose metabolism_Homo sapiens_hsa005000.22524229

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