SLC25A28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1valine metabolic process (GO:0006573)5.24092657
2oxaloacetate metabolic process (GO:0006107)4.78080985
3response to peptidoglycan (GO:0032494)4.71949785
4cellular response to type I interferon (GO:0071357)4.44847155
5type I interferon signaling pathway (GO:0060337)4.44847155
6response to type I interferon (GO:0034340)4.39633771
7negative regulation of interleukin-12 production (GO:0032695)4.36926378
82-oxoglutarate metabolic process (GO:0006103)4.34290209
9macrophage activation involved in immune response (GO:0002281)4.24117240
10lysine catabolic process (GO:0006554)4.23939820
11lysine metabolic process (GO:0006553)4.23939820
12regulation of T-helper 1 cell differentiation (GO:0045625)4.16679859
13NIK/NF-kappaB signaling (GO:0038061)4.06327906
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04022296
15negative regulation of cell killing (GO:0031342)4.04022296
16negative regulation of erythrocyte differentiation (GO:0045647)4.03903184
17regulation of gamma-delta T cell differentiation (GO:0045586)3.96629367
18cysteine metabolic process (GO:0006534)3.95841230
19sulfur amino acid catabolic process (GO:0000098)3.93581401
20regulation of vitamin D biosynthetic process (GO:0060556)3.86029872
21lipopolysaccharide-mediated signaling pathway (GO:0031663)3.83557659
22L-phenylalanine metabolic process (GO:0006558)3.82167274
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.82167274
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.78186665
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.78186665
26modulation by symbiont of host immune response (GO:0052553)3.78186665
27positive regulation by symbiont of host defense response (GO:0052509)3.78186665
28modulation by symbiont of host defense response (GO:0052031)3.78186665
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.78186665
30carnitine shuttle (GO:0006853)3.73692025
31mannose metabolic process (GO:0006013)3.73232410
32defense response to protozoan (GO:0042832)3.71964205
33serine family amino acid catabolic process (GO:0009071)3.71839314
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.67664971
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.67664971
36positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.65315496
37germinal center formation (GO:0002467)3.65043922
38immunoglobulin mediated immune response (GO:0016064)3.62477252
39detection of other organism (GO:0098543)3.62127797
40glycine metabolic process (GO:0006544)3.58779250
41response to muramyl dipeptide (GO:0032495)3.58532955
42interferon-gamma-mediated signaling pathway (GO:0060333)3.57040250
43response to protozoan (GO:0001562)3.56700612
44detection of bacterium (GO:0016045)3.53683145
45regulation of interferon-alpha production (GO:0032647)3.51956425
46negative regulation of cytokine production involved in immune response (GO:0002719)3.49861895
47L-phenylalanine catabolic process (GO:0006559)3.49763483
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.49763483
49fatty acid transmembrane transport (GO:1902001)3.48483951
50tricarboxylic acid metabolic process (GO:0072350)3.47404345
51fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.47377255
52T-helper 1 type immune response (GO:0042088)3.45919899
53neutrophil activation involved in immune response (GO:0002283)3.45875140
54regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.44424207
55regulation of dendritic cell antigen processing and presentation (GO:0002604)3.44403748
56negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.43989436
57negative regulation of cholesterol transport (GO:0032375)3.43650453
58negative regulation of sterol transport (GO:0032372)3.43650453
59positive regulation of type 2 immune response (GO:0002830)3.43404427
60regulation of gamma-delta T cell activation (GO:0046643)3.41575359
61myeloid dendritic cell differentiation (GO:0043011)3.38394431
62biotin metabolic process (GO:0006768)3.36829692
63succinate metabolic process (GO:0006105)3.36089538
64amino-acid betaine metabolic process (GO:0006577)3.35020740
65carnitine transport (GO:0015879)3.33801866
66amino-acid betaine transport (GO:0015838)3.33801866
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33119077
68negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.31241678
69positive regulation of histone deacetylation (GO:0031065)3.31115411
70ribosomal small subunit assembly (GO:0000028)3.30924906
71regulation of T-helper 2 cell differentiation (GO:0045628)3.29777909
72positive regulation of gamma-delta T cell activation (GO:0046645)3.26523816
73antigen processing and presentation of endogenous antigen (GO:0019883)3.24041045
74carnitine transmembrane transport (GO:1902603)3.23147807
75regulation of type I interferon-mediated signaling pathway (GO:0060338)3.21836767
76serine family amino acid metabolic process (GO:0009069)3.18996845
77positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.18840828
78creatine metabolic process (GO:0006600)3.18702883
79nucleotide salvage (GO:0043173)3.18593530
80regulation of interferon-beta biosynthetic process (GO:0045357)3.17279126
81regulation of chronic inflammatory response (GO:0002676)3.16554743
82positive regulation of interferon-alpha production (GO:0032727)3.13972282
83cellular ketone body metabolic process (GO:0046950)3.13556134
84branched-chain amino acid metabolic process (GO:0009081)3.10053359
85regulation of vitamin metabolic process (GO:0030656)3.09373002
86regulation of cholesterol homeostasis (GO:2000188)3.08036220
87leukocyte aggregation (GO:0070486)3.06857864
88carnitine metabolic process (GO:0009437)3.05930364
89triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.05463114
90regulation of chemokine biosynthetic process (GO:0045073)3.05410119
91detection of external biotic stimulus (GO:0098581)3.05243676
92aspartate family amino acid catabolic process (GO:0009068)3.05223098
93regulation of type 2 immune response (GO:0002828)3.05108983
94positive regulation of chemokine biosynthetic process (GO:0045080)3.04719620
95purine nucleotide salvage (GO:0032261)3.04480145
96regulation of antigen processing and presentation (GO:0002577)3.03048200
97regulation of podosome assembly (GO:0071801)3.03036620
98myeloid dendritic cell activation (GO:0001773)3.02368511
99regulation of cytokine secretion involved in immune response (GO:0002739)3.01846166
100aromatic amino acid family catabolic process (GO:0009074)2.99508008
101positive regulation of triglyceride biosynthetic process (GO:0010867)2.98519520
102homocysteine metabolic process (GO:0050667)2.98161599
103JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.97731650
104positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.95260118
105kynurenine metabolic process (GO:0070189)2.94442151
106detection of molecule of bacterial origin (GO:0032490)2.94082507
107regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93646063
108fatty acid homeostasis (GO:0055089)2.93047376
109negative regulation of T cell mediated immunity (GO:0002710)2.92992967
110mucosal-associated lymphoid tissue development (GO:0048537)2.92859015
111Peyers patch development (GO:0048541)2.92859015
112nuclear pore complex assembly (GO:0051292)2.92278788
113quaternary ammonium group transport (GO:0015697)2.90782012
114IMP biosynthetic process (GO:0006188)2.88784170
115regulation of T cell tolerance induction (GO:0002664)2.88627243
116regulation of triglyceride biosynthetic process (GO:0010866)2.87458847
117myeloid cell activation involved in immune response (GO:0002275)2.87457431
118fructose metabolic process (GO:0006000)2.85952841
119positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.85755698
120negative regulation of fatty acid biosynthetic process (GO:0045717)2.85686239
121NADH metabolic process (GO:0006734)2.85683210
122regulation of T-helper cell differentiation (GO:0045622)2.85630826
123fatty acid oxidation (GO:0019395)2.83816657
124T cell migration (GO:0072678)2.82577042
125regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.82494263
1264-hydroxyproline metabolic process (GO:0019471)2.82469466
127negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.82452434
128regulation of fatty acid beta-oxidation (GO:0031998)2.82381771
129positive regulation of antigen processing and presentation (GO:0002579)2.81689128
130urea metabolic process (GO:0019627)2.80818552
131urea cycle (GO:0000050)2.80818552
132negative regulation of production of molecular mediator of immune response (GO:0002701)2.80173744
133alpha-amino acid catabolic process (GO:1901606)2.79240329
134cellular response to interferon-gamma (GO:0071346)2.79194778
135negative regulation of lipid transport (GO:0032369)2.78718884
136positive regulation of triglyceride metabolic process (GO:0090208)2.78175221
137drug transmembrane transport (GO:0006855)2.78096471
138fatty acid beta-oxidation (GO:0006635)2.77207758
139negative regulation of myeloid cell apoptotic process (GO:0033033)2.76854185
140cellular modified amino acid catabolic process (GO:0042219)2.76155316
141activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.76087354
142epithelial cell differentiation involved in prostate gland development (GO:0060742)2.75666150
143lipid oxidation (GO:0034440)2.74744838
144positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.73963831
145one-carbon metabolic process (GO:0006730)2.73921010
146high-density lipoprotein particle remodeling (GO:0034375)2.73755167
147macrophage activation (GO:0042116)2.73537356
148IMP metabolic process (GO:0046040)2.72292826
149positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.71540868
150activation of MAPKKK activity (GO:0000185)2.70328987
151nitrogen cycle metabolic process (GO:0071941)2.70076724
152positive regulation of T-helper cell differentiation (GO:0045624)2.69353416
153cellular amino acid catabolic process (GO:0009063)2.69302040
154detection of biotic stimulus (GO:0009595)2.68762166
155negative regulation of viral genome replication (GO:0045071)2.68203576
156dendritic cell differentiation (GO:0097028)2.68091431
157negative regulation of innate immune response (GO:0045824)2.67604069
158folic acid-containing compound biosynthetic process (GO:0009396)2.67545699
159positive regulation of nuclease activity (GO:0032075)2.67295921
160embryonic placenta development (GO:0001892)2.66651466
161granulocyte activation (GO:0036230)2.65422412
162negative regulation of fatty acid metabolic process (GO:0045922)2.65273627
163regulation of interleukin-12 production (GO:0032655)2.64748327
164cellular response to lipopolysaccharide (GO:0071222)2.63766976
165mature B cell differentiation involved in immune response (GO:0002313)2.63352218
166regulation of tolerance induction (GO:0002643)2.63157041
167maternal placenta development (GO:0001893)2.62532856
168regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.62121726
169regulation of fatty acid biosynthetic process (GO:0042304)2.61497310
170positive regulation of interferon-beta production (GO:0032728)2.61490304
171pentose-phosphate shunt (GO:0006098)2.61487356
172response to interferon-gamma (GO:0034341)2.60949628
173response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.60432449
174response to host immune response (GO:0052572)2.60432449
175tryptophan catabolic process (GO:0006569)2.60328230
176indole-containing compound catabolic process (GO:0042436)2.60328230
177indolalkylamine catabolic process (GO:0046218)2.60328230
178ketone body metabolic process (GO:1902224)2.59956509
179negative regulation of lymphocyte mediated immunity (GO:0002707)2.59777693
180cellular response to molecule of bacterial origin (GO:0071219)2.59273600
181regulation of necroptotic process (GO:0060544)2.56474214
182positive regulation of NF-kappaB import into nucleus (GO:0042346)2.56337374
183regulation of triglyceride catabolic process (GO:0010896)2.56092140
184CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.54660063
185short-chain fatty acid metabolic process (GO:0046459)2.54564477
186negative regulation of nitric oxide biosynthetic process (GO:0045019)2.54511006
187negative regulation of interleukin-6 production (GO:0032715)2.54185365
188modulation by symbiont of host cellular process (GO:0044068)2.54120225
189galactose catabolic process (GO:0019388)2.53585682
190tryptophan metabolic process (GO:0006568)2.52769032
191cellular response to osmotic stress (GO:0071470)2.51747623
192urate metabolic process (GO:0046415)2.49732593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.29568623
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.62690884
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.60853685
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.34237835
5MYC_22102868_ChIP-Seq_BL_Human3.10435055
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.07917249
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.95536390
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69614182
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.67168993
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.63638347
11VDR_21846776_ChIP-Seq_THP-1_Human2.54269856
12GATA1_22025678_ChIP-Seq_K562_Human2.39415884
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28383860
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27348154
15* TCF7_22412390_ChIP-Seq_EML_Mouse2.21916006
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.20573544
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.15047630
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13341726
19KDM2B_26808549_Chip-Seq_DND41_Human2.03809638
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99035308
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98726025
22LXR_22292898_ChIP-Seq_THP-1_Human1.97666104
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97388118
24* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.89997772
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.83198284
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80381312
27SCL_19346495_ChIP-Seq_HPC-7_Human1.78980593
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76356376
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.75895022
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75718081
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74382412
32ZNF263_19887448_ChIP-Seq_K562_Human1.70500742
33* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67174551
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66680024
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66418704
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63483890
37RUNX_20019798_ChIP-Seq_JUKART_Human1.58788840
38MAF_26560356_Chip-Seq_TH1_Human1.58565967
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56054561
40GATA1_22383799_ChIP-Seq_G1ME_Mouse1.55078709
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.52725763
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.52101181
43UTX_26944678_Chip-Seq_JUKART_Human1.51174175
44* MAF_26560356_Chip-Seq_TH2_Human1.51013969
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50413453
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49550307
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46001067
48* GATA1_19941827_ChIP-Seq_MEL_Mouse1.45874481
49* RACK7_27058665_Chip-Seq_MCF-7_Human1.45029971
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44634350
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44352300
52* P68_20966046_ChIP-Seq_HELA_Human1.44202482
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43244987
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42752678
55VDR_24787735_ChIP-Seq_THP-1_Human1.41333971
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.40909995
57CTCF_21964334_ChIP-Seq_BJAB-B_Human1.40804228
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40672636
59KDM2B_26808549_Chip-Seq_K562_Human1.38799590
60* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37340807
61* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36302905
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.36263506
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33769440
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32741807
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32507313
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32034965
67MYB_26560356_Chip-Seq_TH1_Human1.31203058
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.30805394
69NCOR1_26117541_ChIP-Seq_K562_Human1.30150803
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29784118
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27601173
72VDR_24763502_ChIP-Seq_THP-1_Human1.27485542
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27237125
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.27184427
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27137793
76* ATF3_27146783_Chip-Seq_COLON_Human1.27091646
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25863676
78E2F7_22180533_ChIP-Seq_HELA_Human1.25601189
79* CREB1_26743006_Chip-Seq_LNCaP_Human1.25185215
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25061682
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.23359221
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22775704
83* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22611479
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22320983
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.21843117
86* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19564755
87* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19200357
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18935129
89BCOR_27268052_Chip-Seq_Bcells_Human1.17791510
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17509935
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17436545
92* SA1_27219007_Chip-Seq_ERYTHROID_Human1.16951005
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16297752
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16030627
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15897993
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15298972
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12907972
98MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12717444
99* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12440310
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12396955
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12164636
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.11953201
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11508503
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10481271
105CTCF_21964334_Chip-Seq_Bcells_Human1.09313172
106SPI1_23127762_ChIP-Seq_K562_Human1.08469591
107CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07668036
108* PU_27001747_Chip-Seq_BMDM_Mouse1.05938129
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04860755
110SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03718984
111STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03253776
112NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03220629
113SA1_27219007_Chip-Seq_Bcells_Human1.02687876
114DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02568004
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02223029
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01833818
117TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01175610
118* KDM5A_27292631_Chip-Seq_BREAST_Human1.00355260
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99535959
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.99088486
121* PHF8_20622854_ChIP-Seq_HELA_Human0.99018896
122* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98653760
123GATA1_19941826_ChIP-Seq_K562_Human0.98210386
124FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98073682
125BCL6_27268052_Chip-Seq_Bcells_Human0.97970894
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97885481
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97767154
128* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97614363
129KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97505052
130P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97493217
131EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96775517
132IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96615902
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96305537
134FOXM1_23109430_ChIP-Seq_U2OS_Human0.96072695
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95574777
136* SPI1_23547873_ChIP-Seq_NB4_Human0.94988703
137* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94574734
138* SMC4_20622854_ChIP-Seq_HELA_Human0.93174552
139MYB_26560356_Chip-Seq_TH2_Human0.92329049
140* TP63_22573176_ChIP-Seq_HFKS_Human0.91275774
141* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90744381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.98342321
2MP0003724_increased_susceptibility_to3.67277035
3MP0006082_CNS_inflammation3.58548352
4MP0003283_abnormal_digestive_organ3.57446570
5MP0005360_urolithiasis3.40368815
6MP0009840_abnormal_foam_cell3.30634577
7MP0003191_abnormal_cellular_cholesterol3.28207998
8MP0001835_abnormal_antigen_presentation3.13227735
9MP0009785_altered_susceptibility_to3.00683320
10MP0003252_abnormal_bile_duct2.95735226
11MP0005085_abnormal_gallbladder_physiolo2.93109591
12MP0005365_abnormal_bile_salt2.86585342
13MP0002148_abnormal_hypersensitivity_rea2.83836838
14MP0005000_abnormal_immune_tolerance2.73483359
15MP0003303_peritoneal_inflammation2.69935254
16MP0002419_abnormal_innate_immunity2.49879621
17MP0009278_abnormal_bone_marrow2.45486920
18MP0003646_muscle_fatigue2.33971246
19MP0005671_abnormal_response_to2.33745367
20MP0002723_abnormal_immune_serum2.18760717
21MP0001545_abnormal_hematopoietic_system2.17260161
22MP0005397_hematopoietic_system_phenotyp2.17260161
23MP0001533_abnormal_skeleton_physiology2.11135097
24MP0002837_dystrophic_cardiac_calcinosis2.10024741
25MP0002452_abnormal_antigen_presenting2.09132704
26MP0002396_abnormal_hematopoietic_system2.01030725
27MP0002909_abnormal_adrenal_gland2.00108508
28MP0004947_skin_inflammation1.98893247
29MP0003075_altered_response_to1.98665677
30MP0010329_abnormal_lipoprotein_level1.95033138
31MP0003705_abnormal_hypodermis_morpholog1.90970676
32MP0003172_abnormal_lysosome_physiology1.90892093
33MP0002420_abnormal_adaptive_immunity1.90310830
34MP0003300_gastrointestinal_ulcer1.89674324
35MP0001819_abnormal_immune_cell1.89625987
36MP0002254_reproductive_system_inflammat1.89445715
37MP0008875_abnormal_xenobiotic_pharmacok1.86030489
38MP0004130_abnormal_muscle_cell1.84680843
39MP0004510_myositis1.83415495
40MP0009764_decreased_sensitivity_to1.75317526
41MP0001666_abnormal_nutrient_absorption1.72664741
42MP0010352_gastrointestinal_tract_polyps1.69940961
43MP0005332_abnormal_amino_acid1.69849614
44MP0002405_respiratory_system_inflammati1.68408661
45MP0003763_abnormal_thymus_physiology1.63034315
46MP0003690_abnormal_glial_cell1.62104715
47MP0004185_abnormal_adipocyte_glucose1.61995735
48MP0009333_abnormal_splenocyte_physiolog1.60995627
49MP0002138_abnormal_hepatobiliary_system1.58919756
50MP0005666_abnormal_adipose_tissue1.58790817
51MP0003868_abnormal_feces_composition1.57651527
52MP0000609_abnormal_liver_physiology1.57300174
53MP0000343_altered_response_to1.51217596
54MP0003453_abnormal_keratinocyte_physiol1.47322447
55MP0002118_abnormal_lipid_homeostasis1.46313254
56MP0005166_decreased_susceptibility_to1.43668212
57MP0009672_abnormal_birth_weight1.42985657
58MP0000858_altered_metastatic_potential1.41565407
59MP0000716_abnormal_immune_system1.41550020
60MP0008961_abnormal_basal_metabolism1.40834007
61MP0002332_abnormal_exercise_endurance1.40735580
62MP0009643_abnormal_urine_homeostasis1.37183261
63MP0008004_abnormal_stomach_pH1.36958953
64MP0001873_stomach_inflammation1.36054445
65MP0003693_abnormal_embryo_hatching1.35797857
66MP0005220_abnormal_exocrine_pancreas1.34877891
67MP0008260_abnormal_autophagy1.34317274
68MP0002998_abnormal_bone_remodeling1.31330124
69MP0004019_abnormal_vitamin_homeostasis1.31296834
70MP0003448_altered_tumor_morphology1.30255261
71MP0004808_abnormal_hematopoietic_stem1.27414295
72MP0004043_abnormal_pH_regulation1.27327767
73MP0000465_gastrointestinal_hemorrhage1.26111141
74MP0005451_abnormal_body_composition1.24295105
75MP0006036_abnormal_mitochondrial_physio1.22103910
76MP0005319_abnormal_enzyme/_coenzyme1.21589129
77MP0003183_abnormal_peptide_metabolism1.21463066
78MP0004264_abnormal_extraembryonic_tissu1.21122933
79MP0002078_abnormal_glucose_homeostasis1.17391891
80MP0002693_abnormal_pancreas_physiology1.15735062
81MP0000747_muscle_weakness1.13937776
82MP0005334_abnormal_fat_pad1.12270214
83MP0003195_calcinosis1.11952265
84MP0005083_abnormal_biliary_tract1.11682364
85MP0002166_altered_tumor_susceptibility1.11563342
86MP0005164_abnormal_response_to1.09719630
87MP0002429_abnormal_blood_cell1.08892364
88MP0001765_abnormal_ion_homeostasis1.08601912
89MP0003866_abnormal_defecation1.04469642
90MP0005375_adipose_tissue_phenotype1.03682704
91MP0003566_abnormal_cell_adhesion1.02194637
92MP0005464_abnormal_platelet_physiology0.99939427
93MP0000598_abnormal_liver_morphology0.99677040
94MP0001663_abnormal_digestive_system0.98661048
95MP0002933_joint_inflammation0.98030915
96MP0001944_abnormal_pancreas_morphology0.97751489
97MP0004883_abnormal_blood_vessel0.97698755
98MP0001851_eye_inflammation0.97475490
99MP0005390_skeleton_phenotype0.96164078
100MP0003828_pulmonary_edema0.95694674
101MP0001853_heart_inflammation0.95200198
102MP0004036_abnormal_muscle_relaxation0.95141170
103MP0000685_abnormal_immune_system0.94568255
104MP0005330_cardiomyopathy0.92269320
105MP0003091_abnormal_cell_migration0.91738360
106MP0005167_abnormal_blood-brain_barrier0.90910369
107MP0003436_decreased_susceptibility_to0.90807429
108MP0003656_abnormal_erythrocyte_physiolo0.90646898
109MP0005584_abnormal_enzyme/coenzyme_acti0.89888998
110MP0005310_abnormal_salivary_gland0.89514760
111MP0009763_increased_sensitivity_to0.89509219
112MP0010630_abnormal_cardiac_muscle0.88907326
113MP0008469_abnormal_protein_level0.88304815
114MP0005647_abnormal_sex_gland0.87174376
115MP0001501_abnormal_sleep_pattern0.86376547
116MP0003329_amyloid_beta_deposits0.86352022
117MP0000689_abnormal_spleen_morphology0.86185479
118MP0002019_abnormal_tumor_incidence0.85627969
119MP0008874_decreased_physiological_sensi0.83917917
120MP0005058_abnormal_lysosome_morphology0.83558435
121MP0010155_abnormal_intestine_physiology0.83259552
122MP0005636_abnormal_mineral_homeostasis0.82904444
123MP0005670_abnormal_white_adipose0.82848536
124MP0002132_abnormal_respiratory_system0.82571244
125MP0002136_abnormal_kidney_physiology0.81953531
126MP0008057_abnormal_DNA_replication0.81800373
127MP0001845_abnormal_inflammatory_respons0.81092244
128MP0001764_abnormal_homeostasis0.80366311
129MP0000920_abnormal_myelination0.80306817
130MP0001800_abnormal_humoral_immune0.79586747
131MP0000490_abnormal_crypts_of0.78165194
132MP0002398_abnormal_bone_marrow0.78075390
133MP0010234_abnormal_vibrissa_follicle0.78002471
134MP0005387_immune_system_phenotype0.76991858
135MP0001790_abnormal_immune_system0.76991858
136MP0001756_abnormal_urination0.76603765
137MP0005023_abnormal_wound_healing0.76309420
138MP0000249_abnormal_blood_vessel0.75713687
139MP0005535_abnormal_body_temperature0.75192997
140MP0002269_muscular_atrophy0.74734101
141MP0010307_abnormal_tumor_latency0.74358877
142MP0005165_increased_susceptibility_to0.73885818
143MP0005025_abnormal_response_to0.73207721
144MP0009642_abnormal_blood_homeostasis0.73142068
145MP0002971_abnormal_brown_adipose0.72545369
146MP0005410_abnormal_fertilization0.72451533
147MP0009765_abnormal_xenobiotic_induced0.71464224
148MP0000703_abnormal_thymus_morphology0.71414787
149MP0000604_amyloidosis0.70453991
150MP0003279_aneurysm0.67722879
151MP0004087_abnormal_muscle_fiber0.67334933
152MP0005076_abnormal_cell_differentiation0.65808627
153MP0003806_abnormal_nucleotide_metabolis0.65617681
154MP0002086_abnormal_extraembryonic_tissu0.65538487
155MP0002722_abnormal_immune_system0.65188203
156MP0003045_fibrosis0.64240213
157MP0000538_abnormal_urinary_bladder0.64056732
158MP0001542_abnormal_bone_strength0.63552335
159MP0006054_spinal_hemorrhage0.62244716
160MP0005381_digestive/alimentary_phenotyp0.60366730
161MP0003795_abnormal_bone_structure0.59530192

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)4.81021191
2Abnormality of glycosphingolipid metabolism (HP:0004343)4.81021191
3Abnormality of glycolipid metabolism (HP:0010969)4.81021191
4Orchitis (HP:0100796)4.60205492
5Eczematoid dermatitis (HP:0000976)4.56221931
6Myositis (HP:0100614)4.52077158
7Recurrent bacterial skin infections (HP:0005406)4.45789836
8Optic neuritis (HP:0100653)4.43881532
9Retrobulbar optic neuritis (HP:0100654)4.43881532
10Abnormality of macrophages (HP:0004311)4.40479125
11Hyperglycinuria (HP:0003108)4.21873637
12Recurrent abscess formation (HP:0002722)4.15778999
13Systemic lupus erythematosus (HP:0002725)3.97652707
14Stomatitis (HP:0010280)3.95796907
15Mediastinal lymphadenopathy (HP:0100721)3.60906792
16Loss of speech (HP:0002371)3.53392364
17Hyperammonemia (HP:0001987)3.42084461
18Recurrent gram-negative bacterial infections (HP:0005420)3.34376187
19Hyperglycinemia (HP:0002154)3.29604796
20Abnormality of glycine metabolism (HP:0010895)3.25511311
21Abnormality of serine family amino acid metabolism (HP:0010894)3.25511311
22Elevated erythrocyte sedimentation rate (HP:0003565)3.24848249
23Keratoconjunctivitis sicca (HP:0001097)3.20100334
24Gout (HP:0001997)3.16654055
25Abnormality of aromatic amino acid family metabolism (HP:0004338)3.14480556
26Increased IgE level (HP:0003212)3.13262303
27Vasculitis (HP:0002633)3.10505034
28Keratoconjunctivitis (HP:0001096)3.09804215
29Ketosis (HP:0001946)2.99481758
30Prolonged bleeding time (HP:0003010)2.98837799
31Urinary glycosaminoglycan excretion (HP:0003541)2.97828403
32Mucopolysacchariduria (HP:0008155)2.97828403
33Impaired platelet aggregation (HP:0003540)2.96478439
34Abnormal platelet function (HP:0011869)2.96478439
35Hyperlipoproteinemia (HP:0010980)2.96183363
36Recurrent fungal infections (HP:0002841)2.94851546
37Ketoacidosis (HP:0001993)2.92821053
38Asymmetric septal hypertrophy (HP:0001670)2.92186000
39Recurrent skin infections (HP:0001581)2.89158476
40Abnormality of monocarboxylic acid metabolism (HP:0010996)2.87301169
41Obstructive lung disease (HP:0006536)2.84476370
42Chronic obstructive pulmonary disease (HP:0006510)2.84476370
43Pili torti (HP:0003777)2.80743373
44Sensorimotor neuropathy (HP:0007141)2.80727980
45Pulmonary infiltrates (HP:0002113)2.80578887
46Meningitis (HP:0001287)2.80192372
47Abnormality of the thoracic spine (HP:0100711)2.79818030
48Abnormal hair laboratory examination (HP:0003328)2.78993342
49Gastrointestinal infarctions (HP:0005244)2.78721951
50Abnormality of polysaccharide metabolism (HP:0011012)2.78371149
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.78371149
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.78371149
53Increased cerebral lipofuscin (HP:0011813)2.78119608
54High anterior hairline (HP:0009890)2.75563307
55Nuclear cataract (HP:0100018)2.75133709
56Polycythemia (HP:0001901)2.73684823
57Disinhibition (HP:0000734)2.73554340
58Nasal polyposis (HP:0100582)2.72806522
59Joint hemorrhage (HP:0005261)2.71886927
60Xanthomatosis (HP:0000991)2.71605984
61Deep venous thrombosis (HP:0002625)2.69666356
62Myoglobinuria (HP:0002913)2.68086393
63Gingivitis (HP:0000230)2.67661060
64Amyloidosis (HP:0011034)2.65653392
65Recurrent viral infections (HP:0004429)2.64753995
66Autoimmune thrombocytopenia (HP:0001973)2.64211962
67Neurofibrillary tangles (HP:0002185)2.63524697
68Interstitial pulmonary disease (HP:0006530)2.62473040
69Spastic diplegia (HP:0001264)2.62464283
70Back pain (HP:0003418)2.61626219
71Thrombocytosis (HP:0001894)2.60077499
72Gastrointestinal stroma tumor (HP:0100723)2.55924979
73Bundle branch block (HP:0011710)2.55857985
74Hemoptysis (HP:0002105)2.52770685
75Abnormality of purine metabolism (HP:0004352)2.52232148
76Vacuolated lymphocytes (HP:0001922)2.52199878
77Neuronal loss in central nervous system (HP:0002529)2.51210722
78Mutism (HP:0002300)2.50388420
79Axonal loss (HP:0003447)2.50084605
80Colitis (HP:0002583)2.50041607
81Late onset (HP:0003584)2.49191735
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.48667597
83Abnormality of glutamine family amino acid metabolism (HP:0010902)2.47424909
84Increased IgM level (HP:0003496)2.46583162
85Glomerulonephritis (HP:0000099)2.46310844
86Ragged-red muscle fibers (HP:0003200)2.45884089
87Abnormality of the nasal mucosa (HP:0000433)2.45149162
88Encephalitis (HP:0002383)2.42622160
89Abnormality of fatty-acid metabolism (HP:0004359)2.42124877
90Rhabdomyolysis (HP:0003201)2.42098721
91Gangrene (HP:0100758)2.40667015
92Visual hallucinations (HP:0002367)2.37946016
93Hypobetalipoproteinemia (HP:0003563)2.37596422
94Purpura (HP:0000979)2.36239615
95Epidermoid cyst (HP:0200040)2.34022845
96Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33536287
97Dicarboxylic aciduria (HP:0003215)2.33536287
98Hypergammaglobulinemia (HP:0010702)2.33536135
99Exercise-induced myalgia (HP:0003738)2.32223771
100Recurrent cutaneous fungal infections (HP:0011370)2.31401335
101Chronic mucocutaneous candidiasis (HP:0002728)2.31401335
102Supranuclear gaze palsy (HP:0000605)2.28356096
103Cellulitis (HP:0100658)2.28168728
104Arterial thrombosis (HP:0004420)2.24164447
105Urticaria (HP:0001025)2.23893948
106Ventricular tachycardia (HP:0004756)2.23611435
107Myocardial infarction (HP:0001658)2.23200304
108Abnormality of nucleobase metabolism (HP:0010932)2.22739084
109Neoplasm of the oral cavity (HP:0100649)2.22579157
110Atrioventricular block (HP:0001678)2.20389995
111Spontaneous hematomas (HP:0007420)2.20324460
112Increased neuronal autofluorescent lipopigment (HP:0002074)2.14523028
113Subacute progressive viral hepatitis (HP:0006572)2.14166516
114Abnormality of cells of the erythroid lineage (HP:0012130)2.13661041
115Abnormality of the intrinsic pathway (HP:0010989)2.13423578
116Global brain atrophy (HP:0002283)2.11478574
117Episodic fever (HP:0001954)2.11413942
118Polygenic inheritance (HP:0010982)2.09859771
119Emphysema (HP:0002097)2.09713431
120Cerebral inclusion bodies (HP:0100314)2.09248426
121Abnormality of the fingertips (HP:0001211)2.09210911
122Pulmonary embolism (HP:0002204)2.08558510
123Autoimmune hemolytic anemia (HP:0001890)2.07756132
124Abnormality of complement system (HP:0005339)2.06583960
125Acne (HP:0001061)2.06573796
126Intrahepatic cholestasis (HP:0001406)2.05699239
127Petechiae (HP:0000967)2.05520983
128Abnormality of iron homeostasis (HP:0011031)2.05390465
129Hepatocellular carcinoma (HP:0001402)2.04816069
130Progressive muscle weakness (HP:0003323)2.04549303
131Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.04511346
132Exercise-induced muscle cramps (HP:0003710)2.03971685
133Abnormal number of erythroid precursors (HP:0012131)2.03492777
134Heart block (HP:0012722)2.03063590
135Pustule (HP:0200039)2.02508126
136Limb hypertonia (HP:0002509)2.02202290
137Hypolipoproteinemia (HP:0010981)2.01712766
138Menorrhagia (HP:0000132)2.00962223
139Hypochromic anemia (HP:0001931)2.00738552
140Abnormal delayed hypersensitivity skin test (HP:0002963)2.00320772
141Slow saccadic eye movements (HP:0000514)2.00131284
142Hyperuricemia (HP:0002149)1.97738875
143Increased purine levels (HP:0004368)1.97738875
144Colon cancer (HP:0003003)1.96988756
145Restrictive lung disease (HP:0002091)1.96915316
146Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96167934
147Hypoalphalipoproteinemia (HP:0003233)1.95477649
148Long toe (HP:0010511)1.94770153
149Hematochezia (HP:0002573)1.94241685
150Polyneuropathy (HP:0001271)1.93753474
151Hemiplegia (HP:0002301)1.93751657
152Glomerulopathy (HP:0100820)1.93244178
153Abnormality of the pleura (HP:0002103)1.93204212
154Hypoglycemic coma (HP:0001325)1.92764410
155Progressive neurologic deterioration (HP:0002344)1.92248982
156Chest pain (HP:0100749)1.92216657
157Cubitus valgus (HP:0002967)1.92193210
158Basal ganglia calcification (HP:0002135)1.91274937
159Dysmetric saccades (HP:0000641)1.91204635
160Epistaxis (HP:0000421)1.91180049
161Vertigo (HP:0002321)1.90807843
162Apathy (HP:0000741)1.89829199
163Parakeratosis (HP:0001036)1.89597344
164Anorexia (HP:0002039)1.89457704
165Prolonged partial thromboplastin time (HP:0003645)1.88178237
166Increased serum ferritin (HP:0003281)1.87916364
167Papilloma (HP:0012740)1.86980329
168Verrucae (HP:0200043)1.86980329
169Abnormality of the Achilles tendon (HP:0005109)1.84254761
170Gastrointestinal inflammation (HP:0004386)1.83395978
171IgM deficiency (HP:0002850)1.83245976
172Inflammation of the large intestine (HP:0002037)1.81757188
173Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79978476
174Neonatal onset (HP:0003623)1.78966372
175Malnutrition (HP:0004395)1.76040979
176Abnormal atrioventricular conduction (HP:0005150)1.75849385
177Dysostosis multiplex (HP:0000943)1.75817441
178Ulnar deviation of the wrist (HP:0003049)1.74637188
179Meningioma (HP:0002858)1.74522666
180Ulnar bowing (HP:0003031)1.74105689
181Metabolic acidosis (HP:0001942)1.73939436
182Complement deficiency (HP:0004431)1.73307438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.86270378
2PRPF4B3.50830267
3PKN23.39705137
4ICK3.38257331
5PRKD22.84865127
6BRD42.79147959
7MAP3K142.74433944
8RIPK12.54438069
9LATS12.34905758
10TAOK22.32365402
11ERN12.13558098
12BLK2.10655356
13MAP3K132.04457567
14IKBKE2.01920264
15MAP2K32.01481894
16TAOK31.93517766
17PTK61.88297135
18MAP4K11.86656060
19MAP3K101.86158501
20CSK1.79973730
21GRK61.79899933
22PINK11.77684184
23GRK71.74382549
24TAOK11.70493490
25BCKDK1.70045713
26KSR21.66405177
27EEF2K1.64526990
28IKBKB1.62307081
29TTN1.57060177
30NME21.56206977
31PDK41.53648260
32PDK31.53648260
33MAP3K21.51188558
34NEK21.50537542
35BMX1.45876025
36FGR1.43014571
37CDK41.42858505
38DDR21.40934006
39PRKCH1.40093824
40JAK31.36470502
41FES1.34978320
42SIK31.34343542
43MATK1.33767557
44CDC42BPA1.32128406
45IRAK31.30421431
46NTRK31.23423255
47TXK1.21907919
48MAP3K61.21718525
49PDPK11.21514987
50STK111.20567094
51PDK11.19698713
52MOS1.18058719
53IRAK21.16419171
54SIK21.15323972
55TGFBR21.14593103
56PIM11.13896033
57BMPR21.13280891
58MAP3K11.11248084
59SIK11.10433096
60RAF11.09101861
61MAP3K71.08484991
62JAK21.05810946
63LRRK21.05639296
64BTK1.03346161
65STK381.01776673
66CSNK1A1L0.91838023
67MAP3K110.90937154
68PIM20.90363351
69LYN0.89259466
70MARK20.88069774
71CSNK1G10.86632017
72CSNK1G30.85915802
73MST1R0.85410342
74TNK20.84671681
75CAMKK10.82703129
76FLT30.82149414
77EPHB10.81248680
78ALK0.80075751
79ZAP700.78726987
80SYK0.78534581
81CHUK0.78119061
82TYK20.77721227
83CAMK1D0.77704944
84RIPK40.77625777
85MTOR0.75866977
86IRAK10.75431570
87LCK0.75232304
88FGFR40.70367547
89MAPK120.70000289
90TIE10.69566139
91MAPK70.68745322
92STK100.67360534
93GSK3A0.67079931
94RET0.67024142
95ITK0.66644998
96MAP3K80.65462019
97HIPK20.64761814
98CDK70.63564159
99SCYL20.63416337
100DAPK20.63226142
101CSNK1G20.62318626
102TYRO30.62168738
103MAPK40.61549551
104IRAK40.59846176
105MAP3K30.59750354
106CAMKK20.59376272
107KIT0.59251901
108CDK60.58446839
109CSF1R0.56951153
110PRKD30.56759622
111SMG10.56630791
112PRKAA10.56207609
113CDK120.55541944
114TESK10.53762806
115HCK0.51486256
116RPS6KC10.50044852
117RPS6KL10.50044852
118PRKAA20.49212697
119CAMK1G0.48710535
120ARAF0.47566978
121SGK30.47306971
122PDK20.46853000
123MARK30.46673212
124TBK10.46658525
125PKN10.44897757
126NUAK10.44104354
127ABL20.43298078
128EPHA30.40527710
129RPS6KA10.39662205
130JAK10.39552967
131MUSK0.39197718
132FGFR30.38664555
133DMPK0.37860116
134MAPK110.36167202
135WNK40.35367908
136FRK0.34923544
137RPS6KA60.34490790
138MAP2K60.33914670
139RPS6KB10.32980433
140BRSK20.32796855
141FYN0.32030513
142SGK10.31359417
143DYRK1B0.30606890
144PDGFRA0.29776832
145RPS6KA20.29249946
146MAP3K50.29073274
147PRKCQ0.28471583
148MAPKAPK20.28160982
149PAK60.27818916

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21380754
2Nitrogen metabolism_Homo sapiens_hsa009103.07958783
3Arginine biosynthesis_Homo sapiens_hsa002202.76019726
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67064301
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.66173110
6Allograft rejection_Homo sapiens_hsa053302.63636819
7Fatty acid degradation_Homo sapiens_hsa000712.62381328
8Leishmaniasis_Homo sapiens_hsa051402.60145232
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.27955947
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26967763
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.24214645
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.17686817
13Autoimmune thyroid disease_Homo sapiens_hsa053202.17680317
14Graft-versus-host disease_Homo sapiens_hsa053322.17441607
15Asthma_Homo sapiens_hsa053102.15907833
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.06007980
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05200062
18TNF signaling pathway_Homo sapiens_hsa046682.03395320
19Malaria_Homo sapiens_hsa051442.03287092
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.99933360
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96561636
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.95221461
23Tuberculosis_Homo sapiens_hsa051521.90290577
24Carbon metabolism_Homo sapiens_hsa012001.89459835
25Pertussis_Homo sapiens_hsa051331.86129675
26Influenza A_Homo sapiens_hsa051641.83771566
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.83224242
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78446077
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77919412
30Sulfur relay system_Homo sapiens_hsa041221.76858023
31Rheumatoid arthritis_Homo sapiens_hsa053231.74988372
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74684384
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71954462
34African trypanosomiasis_Homo sapiens_hsa051431.70910198
35Tryptophan metabolism_Homo sapiens_hsa003801.69551712
36Type I diabetes mellitus_Homo sapiens_hsa049401.67132766
37PPAR signaling pathway_Homo sapiens_hsa033201.66310044
38Toxoplasmosis_Homo sapiens_hsa051451.65052851
39Biosynthesis of amino acids_Homo sapiens_hsa012301.63605132
40Fat digestion and absorption_Homo sapiens_hsa049751.63344168
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.62376314
42Dorso-ventral axis formation_Homo sapiens_hsa043201.59405345
43Propanoate metabolism_Homo sapiens_hsa006401.58974047
44Legionellosis_Homo sapiens_hsa051341.56113841
45Measles_Homo sapiens_hsa051621.53692645
46Selenocompound metabolism_Homo sapiens_hsa004501.50939001
47beta-Alanine metabolism_Homo sapiens_hsa004101.48733604
48Acute myeloid leukemia_Homo sapiens_hsa052211.48601773
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48399865
50Herpes simplex infection_Homo sapiens_hsa051681.44640914
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.43839604
52Fatty acid metabolism_Homo sapiens_hsa012121.41119767
53Lysosome_Homo sapiens_hsa041421.40047851
54Pyruvate metabolism_Homo sapiens_hsa006201.39361723
55ABC transporters_Homo sapiens_hsa020101.38051901
56Hepatitis C_Homo sapiens_hsa051601.35527670
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.34620118
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32721786
59Salmonella infection_Homo sapiens_hsa051321.32450287
60Bile secretion_Homo sapiens_hsa049761.31948849
61Primary immunodeficiency_Homo sapiens_hsa053401.31781695
62Insulin resistance_Homo sapiens_hsa049311.29963525
63Viral myocarditis_Homo sapiens_hsa054161.29533184
64Chemokine signaling pathway_Homo sapiens_hsa040621.28904151
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27847392
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27544033
67Butanoate metabolism_Homo sapiens_hsa006501.27167507
68Glucagon signaling pathway_Homo sapiens_hsa049221.27006045
69T cell receptor signaling pathway_Homo sapiens_hsa046601.25895132
70Hematopoietic cell lineage_Homo sapiens_hsa046401.25169133
71Lysine degradation_Homo sapiens_hsa003101.24786277
72Pentose phosphate pathway_Homo sapiens_hsa000301.24545764
73Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24022705
74Adipocytokine signaling pathway_Homo sapiens_hsa049201.23658816
75Starch and sucrose metabolism_Homo sapiens_hsa005001.23320756
76B cell receptor signaling pathway_Homo sapiens_hsa046621.22578449
77Antigen processing and presentation_Homo sapiens_hsa046121.21153257
78Non-small cell lung cancer_Homo sapiens_hsa052231.20856651
79Vitamin B6 metabolism_Homo sapiens_hsa007501.20333925
80Histidine metabolism_Homo sapiens_hsa003401.18453258
81Cysteine and methionine metabolism_Homo sapiens_hsa002701.17148820
82Hepatitis B_Homo sapiens_hsa051611.14493949
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11004007
84Cyanoamino acid metabolism_Homo sapiens_hsa004601.08476769
85Drug metabolism - other enzymes_Homo sapiens_hsa009831.07280216
86Complement and coagulation cascades_Homo sapiens_hsa046101.05581342
87mTOR signaling pathway_Homo sapiens_hsa041501.05362815
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02439582
89Peroxisome_Homo sapiens_hsa041461.00977609
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00812883
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00002586
92Shigellosis_Homo sapiens_hsa051310.97621304
93Folate biosynthesis_Homo sapiens_hsa007900.94076612
94Arginine and proline metabolism_Homo sapiens_hsa003300.93629752
95Galactose metabolism_Homo sapiens_hsa000520.93448029
96Glycerolipid metabolism_Homo sapiens_hsa005610.93255912
97Phagosome_Homo sapiens_hsa041450.92745147
98Insulin signaling pathway_Homo sapiens_hsa049100.91874135
99Phenylalanine metabolism_Homo sapiens_hsa003600.89979536
100N-Glycan biosynthesis_Homo sapiens_hsa005100.89140685
101Amoebiasis_Homo sapiens_hsa051460.88815322
102Other glycan degradation_Homo sapiens_hsa005110.86248989
103Apoptosis_Homo sapiens_hsa042100.86136906
104Endometrial cancer_Homo sapiens_hsa052130.85682320
105Long-term potentiation_Homo sapiens_hsa047200.85140092
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83585511
107Fructose and mannose metabolism_Homo sapiens_hsa000510.83568547
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83549607
109Prolactin signaling pathway_Homo sapiens_hsa049170.79803479
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79527236
111Staphylococcus aureus infection_Homo sapiens_hsa051500.78206716
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76933362
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75470657
114Chronic myeloid leukemia_Homo sapiens_hsa052200.73768456
115Pancreatic cancer_Homo sapiens_hsa052120.71784758
116Epstein-Barr virus infection_Homo sapiens_hsa051690.71730839
117Notch signaling pathway_Homo sapiens_hsa043300.71577158
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.67394961
119Bladder cancer_Homo sapiens_hsa052190.65568020
120Fatty acid biosynthesis_Homo sapiens_hsa000610.63471977
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63073147
122Type II diabetes mellitus_Homo sapiens_hsa049300.63065009
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.61556009
124Vitamin digestion and absorption_Homo sapiens_hsa049770.61111213
125HTLV-I infection_Homo sapiens_hsa051660.57830084
126AMPK signaling pathway_Homo sapiens_hsa041520.57107004
127DNA replication_Homo sapiens_hsa030300.56385965
128Glioma_Homo sapiens_hsa052140.55434171
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55325865
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.54204430
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53238522
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52581361
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51425480
134MAPK signaling pathway_Homo sapiens_hsa040100.51320686
135VEGF signaling pathway_Homo sapiens_hsa043700.50583260
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49550325
137Endocytosis_Homo sapiens_hsa041440.49301620
138Platelet activation_Homo sapiens_hsa046110.47578443
139Renal cell carcinoma_Homo sapiens_hsa052110.46704008
140Estrogen signaling pathway_Homo sapiens_hsa049150.46096724
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.46081144
142Tyrosine metabolism_Homo sapiens_hsa003500.44578982
143Inositol phosphate metabolism_Homo sapiens_hsa005620.44462168
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.42722959
145Thyroid hormone synthesis_Homo sapiens_hsa049180.42453968
146Ribosome_Homo sapiens_hsa030100.41870496
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41611565
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39106527
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37467209
150Caffeine metabolism_Homo sapiens_hsa002320.36792966
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35949076
152HIF-1 signaling pathway_Homo sapiens_hsa040660.35404471
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.34788562
154Sulfur metabolism_Homo sapiens_hsa009200.34512879
155FoxO signaling pathway_Homo sapiens_hsa040680.34056576
156ErbB signaling pathway_Homo sapiens_hsa040120.33328501
157Viral carcinogenesis_Homo sapiens_hsa052030.32997723
158Amphetamine addiction_Homo sapiens_hsa050310.32985960
159One carbon pool by folate_Homo sapiens_hsa006700.32946962
160GnRH signaling pathway_Homo sapiens_hsa049120.32831597
161Insulin secretion_Homo sapiens_hsa049110.32199195
162Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31795666
163Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31226469
164Osteoclast differentiation_Homo sapiens_hsa043800.30619486
165Sphingolipid metabolism_Homo sapiens_hsa006000.30310643
166Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30025326
167Choline metabolism in cancer_Homo sapiens_hsa052310.29181809
168Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28736832
169Pancreatic secretion_Homo sapiens_hsa049720.25715260
170Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25117110
171Prion diseases_Homo sapiens_hsa050200.24569391
172Collecting duct acid secretion_Homo sapiens_hsa049660.18919235

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