SLC25A30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Although the outer mitochondrial membrane is permeable to many small metabolites, transport of solutes across the inner mitochondrial membrane is achieved by members of the mitochondrial carrier protein family, such as SLC25A30 (Haguenauer et al., 2005 [PubMed 15809292]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleoside transmembrane transport (GO:1901642)6.06382499
2interkinetic nuclear migration (GO:0022027)5.87605228
3alpha-linolenic acid metabolic process (GO:0036109)5.39227728
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.34816041
5L-phenylalanine catabolic process (GO:0006559)5.34816041
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.30199669
7L-phenylalanine metabolic process (GO:0006558)5.30199669
8muscle filament sliding (GO:0030049)5.20318307
9actin-myosin filament sliding (GO:0033275)5.20318307
10glyoxylate metabolic process (GO:0046487)5.12649302
11fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.02739832
12aromatic amino acid family catabolic process (GO:0009074)4.99975057
13striatum development (GO:0021756)4.99598281
14cysteine metabolic process (GO:0006534)4.89199950
15bile acid biosynthetic process (GO:0006699)4.83119232
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.77391018
17kynurenine metabolic process (GO:0070189)4.76188165
18negative regulation of fibrinolysis (GO:0051918)4.76075226
19tryptophan catabolic process (GO:0006569)4.69979394
20indole-containing compound catabolic process (GO:0042436)4.69979394
21indolalkylamine catabolic process (GO:0046218)4.69979394
22cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.68528489
23tryptophan metabolic process (GO:0006568)4.68270852
24sarcoplasmic reticulum calcium ion transport (GO:0070296)4.64204898
25lysine catabolic process (GO:0006554)4.63231873
26lysine metabolic process (GO:0006553)4.63231873
27positive regulation of action potential (GO:0045760)4.61457935
28response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.57940718
29protein carboxylation (GO:0018214)4.56223138
30peptidyl-glutamic acid carboxylation (GO:0017187)4.56223138
31complement activation, alternative pathway (GO:0006957)4.50323120
32sulfur amino acid catabolic process (GO:0000098)4.43750819
33urea cycle (GO:0000050)4.42139941
34urea metabolic process (GO:0019627)4.42139941
35actin-mediated cell contraction (GO:0070252)4.37529901
36regulation of protein activation cascade (GO:2000257)4.35247714
37high-density lipoprotein particle remodeling (GO:0034375)4.29085565
38serine family amino acid catabolic process (GO:0009071)4.27559492
39myofibril assembly (GO:0030239)4.22181232
40regulation of fibrinolysis (GO:0051917)4.21815129
41regulation of relaxation of muscle (GO:1901077)4.18965934
42regulation of skeletal muscle contraction (GO:0014819)4.15614454
43platelet dense granule organization (GO:0060155)4.15127411
44regulation of complement activation (GO:0030449)4.09257945
45cellular glucuronidation (GO:0052695)4.08506420
46amino-acid betaine metabolic process (GO:0006577)4.06845735
47sarcomere organization (GO:0045214)4.06558663
48homocysteine metabolic process (GO:0050667)4.06372899
49outflow tract septum morphogenesis (GO:0003148)4.04310937
50neuronal action potential (GO:0019228)4.03664405
51bile acid metabolic process (GO:0008206)4.00957278
52nitrogen cycle metabolic process (GO:0071941)3.98012872
53negative regulation of cholesterol transport (GO:0032375)3.94466216
54negative regulation of sterol transport (GO:0032372)3.94466216
55response to inactivity (GO:0014854)3.94198096
56plasma lipoprotein particle clearance (GO:0034381)3.92493049
57urate metabolic process (GO:0046415)3.89559990
58reverse cholesterol transport (GO:0043691)3.84220571
59glycine metabolic process (GO:0006544)3.79201899
60regulation of cholesterol homeostasis (GO:2000188)3.76982723
61regulation of triglyceride catabolic process (GO:0010896)3.76581457
62drug transmembrane transport (GO:0006855)3.74126889
63behavioral response to nicotine (GO:0035095)3.72326658
64serine family amino acid metabolic process (GO:0009069)3.72309793
65phospholipid efflux (GO:0033700)3.70134268
66phospholipid homeostasis (GO:0055091)3.68928430
67nucleoside transport (GO:0015858)3.66900881
68plasma lipoprotein particle remodeling (GO:0034369)3.65112360
69protein-lipid complex remodeling (GO:0034368)3.65112360
70macromolecular complex remodeling (GO:0034367)3.65112360
71aromatic amino acid family metabolic process (GO:0009072)3.65047206
72glucuronate metabolic process (GO:0019585)3.64809862
73uronic acid metabolic process (GO:0006063)3.64809862
74cellular modified amino acid catabolic process (GO:0042219)3.62710810
75ethanol oxidation (GO:0006069)3.61944973
76positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.60108298
77regulation of cholesterol esterification (GO:0010872)3.58975293
78skeletal muscle adaptation (GO:0043501)3.57857633
79acylglycerol homeostasis (GO:0055090)3.57649708
80triglyceride homeostasis (GO:0070328)3.57649708
81positive regulation of fatty acid beta-oxidation (GO:0032000)3.57248371
82dicarboxylic acid biosynthetic process (GO:0043650)3.56710665
83regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.54865376
84skeletal muscle contraction (GO:0003009)3.54662369
85tyrosine metabolic process (GO:0006570)3.53034220
86regulation of glucokinase activity (GO:0033131)3.50948450
87regulation of hexokinase activity (GO:1903299)3.50948450
88thrombin receptor signaling pathway (GO:0070493)3.50869771
89benzene-containing compound metabolic process (GO:0042537)3.50577787
90alpha-amino acid catabolic process (GO:1901606)3.48963525
91positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.48755433
92fibrinolysis (GO:0042730)3.47027203
93reflex (GO:0060004)3.45141177
94valine metabolic process (GO:0006573)3.44409806
952-oxoglutarate metabolic process (GO:0006103)3.42082835
96plasma lipoprotein particle assembly (GO:0034377)3.41703775
97response to nitrosative stress (GO:0051409)3.38622414
98positive regulation of lipid catabolic process (GO:0050996)3.36893249
99cholesterol efflux (GO:0033344)3.36148040
100fatty acid transmembrane transport (GO:1902001)3.35947901
101adult heart development (GO:0007512)3.35814708
102lipoprotein metabolic process (GO:0042157)3.35367198
103cardiac myofibril assembly (GO:0055003)3.35034648
104regulation of action potential (GO:0098900)3.34560153
105indolalkylamine metabolic process (GO:0006586)3.32812550
106negative regulation of leukocyte chemotaxis (GO:0002689)3.32323880
107glutamate metabolic process (GO:0006536)3.31589868
108protein-lipid complex assembly (GO:0065005)3.30340851
109glomerular filtration (GO:0003094)3.29379384
110bile acid and bile salt transport (GO:0015721)3.28652676
111low-density lipoprotein particle clearance (GO:0034383)3.28137907
112serotonin metabolic process (GO:0042428)3.25225750
113regulation of fatty acid beta-oxidation (GO:0031998)3.25216681
114drug catabolic process (GO:0042737)3.25030501
115primary amino compound metabolic process (GO:1901160)3.23991988
116striated muscle contraction (GO:0006941)3.23483841
117creatine metabolic process (GO:0006600)3.23285517
118cellular amino acid catabolic process (GO:0009063)3.22604656
119fatty acid oxidation (GO:0019395)3.21639075
120acetyl-CoA metabolic process (GO:0006084)3.21546276
121serine family amino acid biosynthetic process (GO:0009070)3.20880943
122carnitine metabolic process (GO:0009437)3.20573341
123cholesterol homeostasis (GO:0042632)3.20407040
124fatty acid beta-oxidation (GO:0006635)3.20269585
125epoxygenase P450 pathway (GO:0019373)3.20042876
126negative regulation of Rho protein signal transduction (GO:0035024)3.19634970
127sterol homeostasis (GO:0055092)3.19294771
128regulation of striated muscle contraction (GO:0006942)3.17887663
129response to muscle activity (GO:0014850)3.17550553
130relaxation of cardiac muscle (GO:0055119)3.16929281
131acute-phase response (GO:0006953)3.14433582
132lipid oxidation (GO:0034440)3.14206593
133opsonization (GO:0008228)3.13464929
134drug transport (GO:0015893)3.11686407
135ubiquinone biosynthetic process (GO:0006744)3.09470117
136carnitine shuttle (GO:0006853)3.06726903
137very-low-density lipoprotein particle assembly (GO:0034379)3.06327428
138short-chain fatty acid metabolic process (GO:0046459)3.06220185
139regulation of cholesterol metabolic process (GO:0090181)3.04653923
140regulation of energy homeostasis (GO:2000505)3.04595044
141regulation of sequestering of triglyceride (GO:0010889)3.03096394
142aldehyde catabolic process (GO:0046185)3.02342080
143indole-containing compound metabolic process (GO:0042430)3.01700110
144glandular epithelial cell development (GO:0002068)3.01102358
145adrenergic receptor signaling pathway (GO:0071875)3.00650864
146aspartate family amino acid catabolic process (GO:0009068)3.00108426
147regulation of cholesterol biosynthetic process (GO:0045540)2.99869394
148cellular biogenic amine catabolic process (GO:0042402)2.99463133
149amine catabolic process (GO:0009310)2.99463133
150nucleus localization (GO:0051647)2.97059695
151positive regulation of heart rate (GO:0010460)2.96679768
152actin filament-based movement (GO:0030048)2.93695171
153regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.90502502
154neuronal action potential propagation (GO:0019227)2.89842645
155actomyosin structure organization (GO:0031032)2.86125785
156response to caffeine (GO:0031000)2.85840604
157striated muscle atrophy (GO:0014891)2.85146150
158ubiquinone metabolic process (GO:0006743)2.84099902
159regulation of the force of heart contraction (GO:0002026)2.82979540
160muscle contraction (GO:0006936)2.81904345
161cardiac muscle contraction (GO:0060048)2.81309649
162renal filtration (GO:0097205)2.79660914
163regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.79230831
164retinoic acid receptor signaling pathway (GO:0048384)2.77053089
165regulation of hippo signaling (GO:0035330)2.76277046
166positive regulation of protein kinase C signaling (GO:0090037)2.76271019
167intestinal cholesterol absorption (GO:0030299)2.76064273
168positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.75297963
169cellular response to ATP (GO:0071318)2.74973554
170regulation of actin filament-based movement (GO:1903115)2.72717855
171alanine transport (GO:0032328)2.72004139
172skeletal muscle tissue regeneration (GO:0043403)2.71147813
173regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.70198920
174embryonic digestive tract development (GO:0048566)2.70085521
175cardiac muscle cell differentiation (GO:0055007)2.68923172
176cardiac muscle tissue morphogenesis (GO:0055008)2.68600800
177regulation of cell communication by electrical coupling (GO:0010649)2.63677455
178regulation of sarcomere organization (GO:0060297)2.63245606
179muscle system process (GO:0003012)2.62962828
180cardiac muscle hypertrophy (GO:0003300)2.59410352
181cilium or flagellum-dependent cell motility (GO:0001539)2.58261856
182quinone biosynthetic process (GO:1901663)2.57211991
183muscle tissue morphogenesis (GO:0060415)2.56463276
184detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55900070
185negative regulation of chondrocyte differentiation (GO:0032331)2.55115923
186growth hormone receptor signaling pathway (GO:0060396)2.54342371
187regulation of cardiac muscle contraction (GO:0055117)2.53911301
188cell morphogenesis involved in neuron differentiation (GO:0048667)2.51034306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.51799524
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.98493179
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.48573157
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse5.12908763
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.82995157
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.60070831
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.81366345
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.77726029
9EZH2_22144423_ChIP-Seq_EOC_Human3.32115429
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.20004176
11GBX2_23144817_ChIP-Seq_PC3_Human2.99147813
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92380363
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.88418911
14ZNF274_21170338_ChIP-Seq_K562_Hela2.82566556
15VDR_22108803_ChIP-Seq_LS180_Human2.79668309
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73604305
17* CLOCK_20551151_ChIP-Seq_293T_Human2.67907378
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50269469
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.49369033
20* IRF8_22096565_ChIP-ChIP_GC-B_Human2.29439072
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24809829
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24630718
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.18754512
24PIAS1_25552417_ChIP-Seq_VCAP_Human2.11543462
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08339245
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07309735
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.02185771
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.99343341
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91367973
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.89211658
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88972216
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.84610025
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78737419
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.78443256
35* ER_23166858_ChIP-Seq_MCF-7_Human1.76424424
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71966052
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71899967
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71832158
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.70900163
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.70275559
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67029205
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66662169
43IGF1R_20145208_ChIP-Seq_DFB_Human1.63413144
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61303407
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.60931547
46TAF15_26573619_Chip-Seq_HEK293_Human1.60673544
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59151691
48STAT3_23295773_ChIP-Seq_U87_Human1.58064573
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.57595932
50BCAT_22108803_ChIP-Seq_LS180_Human1.56018450
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55957212
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54076966
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51114104
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49016107
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47592637
56P300_19829295_ChIP-Seq_ESCs_Human1.47142016
57* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46601888
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46590313
59* FOXO3_23340844_ChIP-Seq_DLD1_Human1.45817026
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45599870
61AR_21572438_ChIP-Seq_LNCaP_Human1.45180597
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43105025
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43073377
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43031940
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42839340
66AR_25329375_ChIP-Seq_VCAP_Human1.41774555
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40850004
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40789671
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40009319
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39772550
71AHR_22903824_ChIP-Seq_MCF-7_Human1.39126647
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38851008
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38622703
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.37376910
75TCF4_23295773_ChIP-Seq_U87_Human1.37142792
76SMAD4_21799915_ChIP-Seq_A2780_Human1.36258255
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.35670482
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.35597278
79TP53_16413492_ChIP-PET_HCT116_Human1.32329111
80IRF8_27001747_Chip-Seq_BMDM_Mouse1.32163939
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30843819
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30668039
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30299152
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.30246639
85EWS_26573619_Chip-Seq_HEK293_Human1.29840022
86FUS_26573619_Chip-Seq_HEK293_Human1.27811291
87MYC_22102868_ChIP-Seq_BL_Human1.27003532
88ESR1_21235772_ChIP-Seq_MCF-7_Human1.25145027
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24325527
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23035572
91SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21533137
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20977987
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20753982
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.20104764
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.19991838
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19858807
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.19424882
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19047738
99IRF8_21731497_ChIP-ChIP_J774_Mouse1.18835336
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.18179701
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16535199
102SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13354490
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13026484
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.12745669
105PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12429193
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12275925
107DROSHA_22980978_ChIP-Seq_HELA_Human1.11723564
108* SMAD4_21741376_ChIP-Seq_EPCs_Human1.11391240
109SOX2_19829295_ChIP-Seq_ESCs_Human1.11332525
110NANOG_19829295_ChIP-Seq_ESCs_Human1.11332525
111RXR_22108803_ChIP-Seq_LS180_Human1.10592300
112HNF4A_19822575_ChIP-Seq_HepG2_Human1.09645959
113P53_22387025_ChIP-Seq_ESCs_Mouse1.09589700
114AR_21909140_ChIP-Seq_LNCAP_Human1.09417885
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.09115281
116ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09038028
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08223857
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07720741
119* TCF4_22108803_ChIP-Seq_LS180_Human1.05822363
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05680791
121E2F1_18555785_Chip-Seq_ESCs_Mouse1.05315009
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05256450
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05256450
124TCF7_22412390_ChIP-Seq_EML_Mouse1.04994440
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04870217
126SOX2_21211035_ChIP-Seq_LN229_Gbm1.04132730
127* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03953740
128FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03380784
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03118529
130CJUN_26792858_Chip-Seq_BT549_Human1.03015142
131CBX2_27304074_Chip-Seq_ESCs_Mouse1.02636119
132ELK3_25401928_ChIP-Seq_HUVEC_Human1.02606466
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02408768
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01943786
135STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01691702
136GATA6_25053715_ChIP-Seq_YYC3_Human1.01654022
137CBP_20019798_ChIP-Seq_JUKART_Human1.01337184
138IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01337184
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00545591
140ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00469742
141RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99765199
142IRF1_19129219_ChIP-ChIP_H3396_Human0.99661451
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99558358
144TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99540143
145* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99195145
146ATF3_27146783_Chip-Seq_COLON_Human0.99136222
147CDX2_22108803_ChIP-Seq_LS180_Human0.99023708
148THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98871901
149IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98795242
150STAT3_18555785_Chip-Seq_ESCs_Mouse0.98113500
151PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97728658
152GATA4_25053715_ChIP-Seq_YYC3_Human0.97633314
153KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97344314
154SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97176004
155SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97176004
156FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96644334
157BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95978604
158* MYB_26560356_Chip-Seq_TH1_Human0.95115141
159TP53_22573176_ChIP-Seq_HFKS_Human0.94961694
160ZNF263_19887448_ChIP-Seq_K562_Human0.94114757
161BP1_19119308_ChIP-ChIP_Hs578T_Human0.92300342
162* MAF_26560356_Chip-Seq_TH1_Human0.91215060
163KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91070403
164* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90625044
165SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87194154
166TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84540339
167ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84412781
168CDX2_20551321_ChIP-Seq_CACO-2_Human0.82956070
169P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82914484
170MYB_26560356_Chip-Seq_TH2_Human0.81898867
171UTX_26944678_Chip-Seq_JUKART_Human0.81391528
172TRIM28_21343339_ChIP-Seq_HEK293_Human0.81181547
173GATA1_22025678_ChIP-Seq_K562_Human0.80286597
174* PU_27001747_Chip-Seq_BMDM_Mouse0.79497798
175* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78740016
176GATA2_21666600_ChIP-Seq_HMVEC_Human0.78376315
177VDR_21846776_ChIP-Seq_THP-1_Human0.76940196
178RUNX1_22412390_ChIP-Seq_EML_Mouse0.76163345
179FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.75513873
180POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75405593
181GATA2_19941826_ChIP-Seq_K562_Human0.75237732
182RUNX_20019798_ChIP-Seq_JUKART_Human0.74315718
183NCOR1_26117541_ChIP-Seq_K562_Human0.73925148
184PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72350800
185RACK7_27058665_Chip-Seq_MCF-7_Human0.72052240
186RXRA_24833708_ChIP-Seq_LIVER_Mouse0.71324914
187SOX2_20726797_ChIP-Seq_SW620_Human0.69724680
188* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68593077
189* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68593077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.43852321
2MP0005360_urolithiasis5.81233451
3MP0003646_muscle_fatigue4.83448082
4MP0005365_abnormal_bile_salt4.62068104
5MP0010030_abnormal_orbit_morphology4.47335191
6MP0005085_abnormal_gallbladder_physiolo4.42698376
7MP0004145_abnormal_muscle_electrophysio4.10792839
8MP0000569_abnormal_digit_pigmentation4.06816216
9MP0005248_abnormal_Harderian_gland3.74463910
10MP0008875_abnormal_xenobiotic_pharmacok3.62471960
11MP0003252_abnormal_bile_duct3.31358019
12MP0003806_abnormal_nucleotide_metabolis3.13661313
13MP0002837_dystrophic_cardiac_calcinosis3.12890888
14MP0004084_abnormal_cardiac_muscle3.10218376
15MP0004036_abnormal_muscle_relaxation3.01657380
16MP0003136_yellow_coat_color3.01206586
17MP0010329_abnormal_lipoprotein_level2.72948303
18MP0009840_abnormal_foam_cell2.72316434
19MP0004215_abnormal_myocardial_fiber2.60857227
20MP0000749_muscle_degeneration2.56677242
21MP0002332_abnormal_exercise_endurance2.52399701
22MP0000751_myopathy2.42523449
23MP0004484_altered_response_of2.40721284
24MP0005083_abnormal_biliary_tract2.34677798
25MP0003705_abnormal_hypodermis_morpholog2.33292332
26MP0003191_abnormal_cellular_cholesterol2.32831898
27MP0005332_abnormal_amino_acid2.22339813
28MP0005620_abnormal_muscle_contractility2.19499145
29MP0002138_abnormal_hepatobiliary_system2.10979752
30MP0004019_abnormal_vitamin_homeostasis2.07512613
31MP0005174_abnormal_tail_pigmentation2.06889529
32MP0000609_abnormal_liver_physiology2.01847550
33MP0002106_abnormal_muscle_physiology1.98763867
34MP0003195_calcinosis1.94088038
35MP0008775_abnormal_heart_ventricle1.89920079
36MP0003300_gastrointestinal_ulcer1.75464358
37MP0002876_abnormal_thyroid_physiology1.71895983
38MP0001666_abnormal_nutrient_absorption1.71326219
39MP0002972_abnormal_cardiac_muscle1.70955535
40MP0004087_abnormal_muscle_fiber1.64570764
41MP0005369_muscle_phenotype1.61703518
42MP0002102_abnormal_ear_morphology1.58218381
43MP0005319_abnormal_enzyme/_coenzyme1.56943678
44MP0002118_abnormal_lipid_homeostasis1.55789103
45MP0002282_abnormal_trachea_morphology1.52267064
46MP0005330_cardiomyopathy1.50739113
47MP0006138_congestive_heart_failure1.50204623
48MP0009643_abnormal_urine_homeostasis1.49253351
49MP0000747_muscle_weakness1.47124569
50MP0002269_muscular_atrophy1.45847939
51MP0005171_absent_coat_pigmentation1.43726296
52MP0005266_abnormal_metabolism1.42039334
53MP0003436_decreased_susceptibility_to1.40811950
54MP0001986_abnormal_taste_sensitivity1.38897147
55MP0000750_abnormal_muscle_regeneration1.36412344
56MP0010352_gastrointestinal_tract_polyps1.35014299
57MP0009764_decreased_sensitivity_to1.34147315
58MP0001984_abnormal_olfaction1.34134201
59MP0003011_delayed_dark_adaptation1.33446569
60MP0000759_abnormal_skeletal_muscle1.33363900
61MP0008438_abnormal_cutaneous_collagen1.32860002
62MP0001544_abnormal_cardiovascular_syste1.32330757
63MP0005385_cardiovascular_system_phenoty1.32330757
64MP0000598_abnormal_liver_morphology1.28984956
65MP0005084_abnormal_gallbladder_morpholo1.28113197
66MP0002249_abnormal_larynx_morphology1.27274947
67MP0010234_abnormal_vibrissa_follicle1.27141967
68MP0005584_abnormal_enzyme/coenzyme_acti1.26358643
69MP0000613_abnormal_salivary_gland1.25048265
70MP0003186_abnormal_redox_activity1.22514157
71MP0003137_abnormal_impulse_conducting1.22405414
72MP0003880_abnormal_central_pattern1.21835583
73MP0004947_skin_inflammation1.20336007
74MP0002971_abnormal_brown_adipose1.19336990
75MP0005058_abnormal_lysosome_morphology1.17386868
76MP0000230_abnormal_systemic_arterial1.16900984
77MP0004142_abnormal_muscle_tone1.15344342
78MP0003868_abnormal_feces_composition1.13240027
79MP0005595_abnormal_vascular_smooth1.11605892
80MP0005451_abnormal_body_composition1.10878990
81MP0003566_abnormal_cell_adhesion1.10593245
82MP0008469_abnormal_protein_level1.08675086
83MP0005464_abnormal_platelet_physiology1.07170981
84MP0009763_increased_sensitivity_to1.06178687
85MP0005551_abnormal_eye_electrophysiolog1.04824686
86MP0002136_abnormal_kidney_physiology1.04602746
87MP0004085_abnormal_heartbeat1.03034339
88MP0005647_abnormal_sex_gland1.02907399
89MP0005023_abnormal_wound_healing1.02342271
90MP0003453_abnormal_keratinocyte_physiol1.01527923
91MP0000534_abnormal_ureter_morphology0.99777717
92MP0003878_abnormal_ear_physiology0.99251205
93MP0005377_hearing/vestibular/ear_phenot0.99251205
94MP0004510_myositis0.98854423
95MP0002127_abnormal_cardiovascular_syste0.98422478
96MP0009053_abnormal_anal_canal0.98045217
97MP0003950_abnormal_plasma_membrane0.97968028
98MP0010368_abnormal_lymphatic_system0.97668716
99MP0001764_abnormal_homeostasis0.97166058
100MP0003283_abnormal_digestive_organ0.95903867
101MP0002254_reproductive_system_inflammat0.95187511
102MP0006082_CNS_inflammation0.93873471
103MP0005636_abnormal_mineral_homeostasis0.92598554
104MP0004043_abnormal_pH_regulation0.91122014
105MP0001756_abnormal_urination0.90065844
106MP0001853_heart_inflammation0.89855633
107MP0002166_altered_tumor_susceptibility0.89280796
108MP0002928_abnormal_bile_duct0.88841599
109MP0003656_abnormal_erythrocyte_physiolo0.88584430
110MP0001485_abnormal_pinna_reflex0.88188703
111MP0000604_amyloidosis0.86646946
112MP0004885_abnormal_endolymph0.86556618
113MP0009384_cardiac_valve_regurgitation0.85100942
114MP0005076_abnormal_cell_differentiation0.84684404
115MP0010630_abnormal_cardiac_muscle0.83772559
116MP0005408_hypopigmentation0.83739257
117MP0004233_abnormal_muscle_weight0.83347381
118MP0001915_intracranial_hemorrhage0.81719088
119MP0001845_abnormal_inflammatory_respons0.81264919
120MP0004742_abnormal_vestibular_system0.80887272
121MP0009278_abnormal_bone_marrow0.79573488
122MP0001661_extended_life_span0.79475374
123MP0003091_abnormal_cell_migration0.78309212
124MP0010307_abnormal_tumor_latency0.77870835
125MP0001835_abnormal_antigen_presentation0.77009049
126MP0004130_abnormal_muscle_cell0.76544468
127MP0000427_abnormal_hair_cycle0.76022680
128MP0003959_abnormal_lean_body0.75603415
129MP0000685_abnormal_immune_system0.74517363
130MP0009642_abnormal_blood_homeostasis0.73926001
131MP0009697_abnormal_copulation0.72941141
132MP0005397_hematopoietic_system_phenotyp0.72224892
133MP0001545_abnormal_hematopoietic_system0.72224892
134MP0000372_irregular_coat_pigmentation0.71196649
135MP0005253_abnormal_eye_physiology0.71142025
136MP0002419_abnormal_innate_immunity0.70802878
137MP0005670_abnormal_white_adipose0.70660493
138MP0001533_abnormal_skeleton_physiology0.70574617
139MP0003828_pulmonary_edema0.69947534
140MP0002108_abnormal_muscle_morphology0.69364087
141MP0002168_other_aberrant_phenotype0.68855016
142MP0009785_altered_susceptibility_to0.68551050
143MP0000858_altered_metastatic_potential0.67811749
144MP0005666_abnormal_adipose_tissue0.67674436
145MP0006036_abnormal_mitochondrial_physio0.67206283
146MP0002006_tumorigenesis0.66746190
147MP0009765_abnormal_xenobiotic_induced0.66580852
148MP0005645_abnormal_hypothalamus_physiol0.66489148
149MP0005025_abnormal_response_to0.65995512
150MP0005220_abnormal_exocrine_pancreas0.65816344
151MP0002060_abnormal_skin_morphology0.64169864
152MP0002067_abnormal_sensory_capabilities0.63032474
153MP0005166_decreased_susceptibility_to0.62846068
154MP0003279_aneurysm0.62482970
155MP0003303_peritoneal_inflammation0.62201844
156MP0000013_abnormal_adipose_tissue0.61498795
157MP0005197_abnormal_uvea_morphology0.60485222
158MP0005167_abnormal_blood-brain_barrier0.60385824
159MP0001800_abnormal_humoral_immune0.60384502
160MP0003724_increased_susceptibility_to0.59067495
161MP0002796_impaired_skin_barrier0.58998026
162MP0000249_abnormal_blood_vessel0.58953805
163MP0000383_abnormal_hair_follicle0.58790035
164MP0003045_fibrosis0.58535061
165MP0000371_diluted_coat_color0.58351155
166MP0002135_abnormal_kidney_morphology0.58140057
167MP0001501_abnormal_sleep_pattern0.57896441
168MP0010155_abnormal_intestine_physiology0.57712386
169MP0005275_abnormal_skin_tensile0.57639896
170MP0001216_abnormal_epidermal_layer0.55447559
171MP0005334_abnormal_fat_pad0.54947915
172MP0008873_increased_physiological_sensi0.54062224
173MP0005376_homeostasis/metabolism_phenot0.54059446
174MP0002452_abnormal_antigen_presenting0.53879680
175MP0002932_abnormal_joint_morphology0.53523542
176MP0005000_abnormal_immune_tolerance0.52703346
177MP0001881_abnormal_mammary_gland0.52292659
178MP0004883_abnormal_blood_vessel0.52183327
179MP0002234_abnormal_pharynx_morphology0.52116731
180MP0001873_stomach_inflammation0.52088137

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.04799816
2Abnormal pancreas size (HP:0012094)5.87608432
3Deep venous thrombosis (HP:0002625)5.77090052
4Nemaline bodies (HP:0003798)5.70211643
5Intrahepatic cholestasis (HP:0001406)5.68107158
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.64745446
7Xanthomatosis (HP:0000991)5.52010331
8Muscle hypertrophy of the lower extremities (HP:0008968)5.36014868
9Abnormality of monocarboxylic acid metabolism (HP:0010996)5.18446778
10Hypobetalipoproteinemia (HP:0003563)4.80014030
11Calf muscle hypertrophy (HP:0008981)4.73385734
12Annular pancreas (HP:0001734)4.64573886
13Abnormality of aromatic amino acid family metabolism (HP:0004338)4.63598388
14Complement deficiency (HP:0004431)4.59254800
15Type 1 muscle fiber predominance (HP:0003803)4.30238591
16Prolonged partial thromboplastin time (HP:0003645)4.26333221
17Exercise-induced myalgia (HP:0003738)4.14897079
18Abnormality of the common coagulation pathway (HP:0010990)4.07921937
19Hyporeflexia of lower limbs (HP:0002600)3.97558303
20Bundle branch block (HP:0011710)3.95140852
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.91280758
22Epidermoid cyst (HP:0200040)3.89674130
23Subaortic stenosis (HP:0001682)3.79212325
24Abnormality of the left ventricular outflow tract (HP:0011103)3.79212325
25Hyperlipoproteinemia (HP:0010980)3.72216346
26Exercise-induced muscle cramps (HP:0003710)3.70503652
27Hypolipoproteinemia (HP:0010981)3.70371585
28Joint hemorrhage (HP:0005261)3.67739755
29Sudden death (HP:0001699)3.63883750
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.63149204
31Large for gestational age (HP:0001520)3.61808175
32Abnormality of the calf musculature (HP:0001430)3.61123434
33Myocardial infarction (HP:0001658)3.57333861
34Abnormality of complement system (HP:0005339)3.57204101
35Hyperammonemia (HP:0001987)3.53974972
36Heart block (HP:0012722)3.52702270
37Asymmetric septal hypertrophy (HP:0001670)3.43148997
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.41736303
39Muscle fiber splitting (HP:0003555)3.41561877
40Fat malabsorption (HP:0002630)3.39126545
41EMG: myopathic abnormalities (HP:0003458)3.37785008
42Atrioventricular block (HP:0001678)3.36787374
43Abnormality of aspartate family amino acid metabolism (HP:0010899)3.31979223
44Hypoalphalipoproteinemia (HP:0003233)3.31166012
45Abnormality of alanine metabolism (HP:0010916)3.25355870
46Hyperalaninemia (HP:0003348)3.25355870
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.25355870
48Pancreatic cysts (HP:0001737)3.23125168
49Anophthalmia (HP:0000528)3.19555976
50Hyperglycinemia (HP:0002154)3.19130146
51Bicornuate uterus (HP:0000813)3.15171573
52Recurrent gram-negative bacterial infections (HP:0005420)3.12653044
53Hyperglycinuria (HP:0003108)3.11738486
54Abnormality of the renal cortex (HP:0011035)3.10956737
55Abnormal atrioventricular conduction (HP:0005150)3.10766017
56Abnormality of serine family amino acid metabolism (HP:0010894)3.07048012
57Abnormality of glycine metabolism (HP:0010895)3.07048012
58Ketosis (HP:0001946)3.06891722
59Spastic diplegia (HP:0001264)3.05599757
60Esophageal varix (HP:0002040)3.03838952
61Abnormality of fatty-acid metabolism (HP:0004359)3.02445375
62Atrial fibrillation (HP:0005110)3.00686981
63Rimmed vacuoles (HP:0003805)2.99668883
64Hepatocellular carcinoma (HP:0001402)2.99232804
65Hypercholesterolemia (HP:0003124)2.98306478
66Distal arthrogryposis (HP:0005684)2.97001289
67Primary atrial arrhythmia (HP:0001692)2.96136089
68Congenital sensorineural hearing impairment (HP:0008527)2.95824366
69Tubular atrophy (HP:0000092)2.93536926
70Syncope (HP:0001279)2.90801547
71Hypoglycemic coma (HP:0001325)2.90058344
72Abnormality of methionine metabolism (HP:0010901)2.87630366
73Abnormality of purine metabolism (HP:0004352)2.86295553
74Abnormality of nucleobase metabolism (HP:0010932)2.83647974
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.79828927
76Abnormality of the intrinsic pathway (HP:0010989)2.79570565
77Abnormality of pyrimidine metabolism (HP:0004353)2.78352816
78Lipoatrophy (HP:0100578)2.77397771
79Systemic lupus erythematosus (HP:0002725)2.77220099
80Supraventricular tachycardia (HP:0004755)2.75516358
81Supraventricular arrhythmia (HP:0005115)2.68324228
82Ventricular tachycardia (HP:0004756)2.68279056
83Areflexia of lower limbs (HP:0002522)2.64928479
84Gout (HP:0001997)2.61587151
85Polydipsia (HP:0001959)2.60698452
86Abnormal drinking behavior (HP:0030082)2.60698452
87Pancreatic fibrosis (HP:0100732)2.59676862
88Vascular calcification (HP:0004934)2.59244232
89Skin nodule (HP:0200036)2.53534263
90Steatorrhea (HP:0002570)2.49218834
91Myoglobinuria (HP:0002913)2.48616989
92Type II lissencephaly (HP:0007260)2.48144366
93Cardiovascular calcification (HP:0011915)2.45737327
94Cholecystitis (HP:0001082)2.43775540
95Abnormal gallbladder physiology (HP:0012438)2.43775540
96Acanthocytosis (HP:0001927)2.43530309
97Abnormality of iron homeostasis (HP:0011031)2.38296724
98Hyperbilirubinemia (HP:0002904)2.37574359
99Congenital stationary night blindness (HP:0007642)2.36299725
100Abnormality of transition element cation homeostasis (HP:0011030)2.36142774
101Ventricular fibrillation (HP:0001663)2.35132790
102Upper motor neuron abnormality (HP:0002127)2.33995482
103Increased mean platelet volume (HP:0011877)2.33872299
104Hyperventilation (HP:0002883)2.33271689
105Spontaneous abortion (HP:0005268)2.32256574
106Abnormal cartilage morphology (HP:0002763)2.32231674
107EMG: neuropathic changes (HP:0003445)2.30654071
108Generalized muscle weakness (HP:0003324)2.30445479
109Hydroxyprolinuria (HP:0003080)2.29436188
110Abnormality of proline metabolism (HP:0010907)2.29436188
111Broad nasal tip (HP:0000455)2.28564845
112Abnormality of the renal medulla (HP:0100957)2.27155894
113Conjugated hyperbilirubinemia (HP:0002908)2.26517738
114True hermaphroditism (HP:0010459)2.26087051
115Molar tooth sign on MRI (HP:0002419)2.25809587
116Abnormality of midbrain morphology (HP:0002418)2.25809587
117Genetic anticipation (HP:0003743)2.25385435
118Left ventricular hypertrophy (HP:0001712)2.24762377
119Gingival bleeding (HP:0000225)2.24480915
120Ventricular arrhythmia (HP:0004308)2.24304251
121Nephritis (HP:0000123)2.24248092
122Abnormality of the pons (HP:0007361)2.23009090
123Frequent falls (HP:0002359)2.22017851
124Malnutrition (HP:0004395)2.21690092
125Ulnar deviation of the wrist (HP:0003049)2.21310121
126Myotonia (HP:0002486)2.21223559
127Menorrhagia (HP:0000132)2.18500512
128Glomerulonephritis (HP:0000099)2.17393601
129Nephronophthisis (HP:0000090)2.16856810
130Polyuria (HP:0000103)2.15582515
131Hypoplasia of the pons (HP:0012110)2.15531616
132Abnormal platelet volume (HP:0011876)2.14211287
133Dilated cardiomyopathy (HP:0001644)2.13839847
134Rhabdomyolysis (HP:0003201)2.13706117
135Neck muscle weakness (HP:0000467)2.13050290
136Increased serum ferritin (HP:0003281)2.12836954
137Mitral stenosis (HP:0001718)2.12064299
138Thrombophlebitis (HP:0004418)2.11766557
139Tubulointerstitial fibrosis (HP:0005576)2.10515184
140Hemorrhage of the eye (HP:0011885)2.10235814
141Severe muscular hypotonia (HP:0006829)2.09120363
142Hyperkalemia (HP:0002153)2.08637925
143Ketoacidosis (HP:0001993)2.08178381
144Difficulty running (HP:0009046)2.03558364
145Attenuation of retinal blood vessels (HP:0007843)2.02950738
146Abnormality of serum amino acid levels (HP:0003112)2.01305626
147Myopathic facies (HP:0002058)2.00015700
148Decreased circulating renin level (HP:0003351)1.97164519
149Proximal tubulopathy (HP:0000114)1.97116802
150Axonal loss (HP:0003447)1.94625695
151Toxemia of pregnancy (HP:0100603)1.94071365
152Nausea (HP:0002018)1.93434921
153Sensorimotor neuropathy (HP:0007141)1.92598824
154Neonatal onset (HP:0003623)1.92231213
155Tetraparesis (HP:0002273)1.91001763
156Peritonitis (HP:0002586)1.90991401
157Metabolic acidosis (HP:0001942)1.90942431
158Abnormal enzyme/coenzyme activity (HP:0012379)1.90842545
159Cholelithiasis (HP:0001081)1.90705947
160Facial diplegia (HP:0001349)1.90674532
161Hemiparesis (HP:0001269)1.89813655
162Progressive cerebellar ataxia (HP:0002073)1.89070937
163Rickets (HP:0002748)1.86006822
164Abnormal gallbladder morphology (HP:0012437)1.84942228
165Gaze-evoked nystagmus (HP:0000640)1.83935828
166Muscular dystrophy (HP:0003560)1.83688085
167Glomerulosclerosis (HP:0000096)1.83447518
168Generalized aminoaciduria (HP:0002909)1.83372931
169Abnormality of the Achilles tendon (HP:0005109)1.82205657
170Abnormal urine output (HP:0012590)1.81571917
171Increased purine levels (HP:0004368)1.80637862
172Hyperuricemia (HP:0002149)1.80637862
173Focal segmental glomerulosclerosis (HP:0000097)1.79585552
174Hypochromic microcytic anemia (HP:0004840)1.79469375
175Inability to walk (HP:0002540)1.78950117
176Pancreatitis (HP:0001733)1.78798993
177Palpitations (HP:0001962)1.78520859
178Abnormality of potassium homeostasis (HP:0011042)1.77916274
179Absent phalangeal crease (HP:0006109)1.77704878
180Prolonged QT interval (HP:0001657)1.77463452
181Protuberant abdomen (HP:0001538)1.76864142
182Hemiplegia (HP:0002301)1.76521168
183Pheochromocytoma (HP:0002666)1.76452165
184Delayed CNS myelination (HP:0002188)1.76423581
185Hematochezia (HP:0002573)1.75501899
186Fair hair (HP:0002286)1.73172953
187Abnormal biliary tract physiology (HP:0012439)1.73077483
188Alkalosis (HP:0001948)1.72450958
189Autoimmune thrombocytopenia (HP:0001973)1.72349619
190Reticulocytosis (HP:0001923)1.70696137
191Abnormality of alkaline phosphatase activity (HP:0004379)1.69123694
192Abnormality of the vasculature of the conjunctiva (HP:0008054)1.67945566
193Elevated alkaline phosphatase (HP:0003155)1.67262413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.46580958
2PINK13.73243522
3PNCK3.58553442
4ERN13.00594228
5PKN22.65102705
6PHKG12.60687493
7PHKG22.60687493
8FGFR42.56515249
9BMPR1B2.56329607
10TRIB32.52287103
11MAP3K102.37936819
12RIPK12.35912730
13SIK12.30499020
14TYK22.28934468
15STK102.12461944
16LATS12.08099239
17TTN2.07483851
18EEF2K2.07140085
19BCKDK2.05589106
20ADRBK22.04097879
21EPHA22.03356894
22MAP3K142.00715229
23TNIK1.91366175
24TAOK31.81193995
25PIK3CA1.78495268
26MST1R1.77410340
27ERBB41.75741345
28FLT31.72013905
29TBK11.69609570
30MAP4K11.67627820
31PTK61.66897120
32CAMKK21.66454779
33GRK71.66164498
34LRRK21.65624766
35JAK11.63976852
36GRK11.63152339
37BMX1.61362813
38NEK91.60877288
39NLK1.60543748
40TGFBR21.57516421
41SCYL21.54407711
42MAP3K31.52389293
43MAPK151.50792118
44MAP2K31.48764024
45CDK121.44996452
46CDK61.42882320
47STK31.35045190
48AKT31.33991357
49MUSK1.32341543
50PDGFRA1.28741656
51FRK1.25523920
52MAPKAPK31.23132498
53PIM11.22260713
54PIK3CG1.16427820
55MET1.15379098
56CSF1R1.12863909
57MAPK111.11469800
58GRK61.10953202
59TGFBR11.09662820
60JAK31.09110054
61DAPK21.06972812
62ITK1.06751437
63CAMK1D1.05290738
64JAK21.04562209
65TIE11.03268268
66MAP2K41.02071018
67PTK2B1.00329669
68PAK30.99099565
69INSRR0.98722521
70DMPK0.98026906
71CSK0.97855143
72MAPK130.97301607
73EPHB10.92525258
74CHUK0.91433270
75SGK20.90547748
76FGFR30.90436108
77IKBKB0.89478631
78PTK20.87023345
79IKBKE0.84184565
80MTOR0.83825316
81DYRK1B0.83767274
82MAPK120.81949445
83PRKAA10.81463043
84ADRBK10.80058796
85RPS6KA40.79193449
86BRSK20.79022120
87WNK30.78132159
88MAP3K70.77587853
89MYLK0.76262969
90ABL20.75402510
91MAP3K80.75382588
92ZAP700.74490495
93RPS6KB20.74115726
94TRPM70.73885165
95MAP2K20.72563719
96WNK10.71982908
97PAK20.71926765
98TSSK60.71498304
99BTK0.70496450
100MOS0.70372769
101KIT0.69147751
102CDK40.68046082
103CAMK1G0.67906163
104GSK3A0.66229260
105KDR0.66079400
106CASK0.65557779
107MAP3K20.64524605
108MARK30.63265272
109CAMK10.62817695
110PIM20.61999620
111MAP2K60.61221778
112EGFR0.60706630
113CAMK40.60270030
114MAPK40.59927373
115NEK20.59215506
116MARK10.56940577
117MAP3K40.56897905
118IRAK10.55748924
119TXK0.55035577
120STK390.54757076
121PDK20.54586467
122STK240.54527343
123EPHA30.54175515
124TYRO30.54143853
125PRKCE0.53909004
126MAP3K110.53387105
127WNK40.53265425
128NUAK10.52939126
129PRKCQ0.52130849
130CAMK2D0.52094231
131SGK2230.51813105
132SGK4940.51813105
133ACVR1B0.50559799
134PDGFRB0.50154983
135MAP4K20.49956320
136PRKACA0.49590233
137TEC0.48653958
138HCK0.48390909
139MATK0.47222797
140STK38L0.46972642
141SGK30.44827586
142MAP2K10.44541368
143IGF1R0.43728504
144ABL10.43646722
145OXSR10.42370257
146PRKAA20.42048132
147NEK10.41972237
148STK40.41328183
149STK110.40770835
150NTRK30.40228569
151TNK20.39140392
152PDK30.38863843
153PDK40.38863843
154BLK0.38173486
155RET0.36729908
156RPS6KA60.36723387
157PRKG10.36689945
158INSR0.36529148
159MAPK70.35692500
160SYK0.34961189
161PAK40.34734498
162PRKACG0.34045774
163FER0.33988301
164CAMK2A0.33830773
165FGFR10.32958471
166PRKCG0.32447914
167LCK0.32376182
168PDK10.31615857
169ROCK10.31341726
170ERBB20.30543066

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.94562687
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.63369293
3Nitrogen metabolism_Homo sapiens_hsa009103.48809193
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96378084
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.84869077
6Complement and coagulation cascades_Homo sapiens_hsa046102.65889467
7Arginine biosynthesis_Homo sapiens_hsa002202.60636083
8Fatty acid degradation_Homo sapiens_hsa000712.59597333
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51131578
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.42675644
11Linoleic acid metabolism_Homo sapiens_hsa005912.39168570
12Tryptophan metabolism_Homo sapiens_hsa003802.38885915
13Dilated cardiomyopathy_Homo sapiens_hsa054142.36273173
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34470815
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10650758
16PPAR signaling pathway_Homo sapiens_hsa033202.10047939
17Cardiac muscle contraction_Homo sapiens_hsa042602.08076124
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03194150
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00303524
20Staphylococcus aureus infection_Homo sapiens_hsa051501.99559168
21Peroxisome_Homo sapiens_hsa041461.99353204
22Fatty acid metabolism_Homo sapiens_hsa012121.86298678
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.82926470
24Selenocompound metabolism_Homo sapiens_hsa004501.82325295
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.80998199
26Caffeine metabolism_Homo sapiens_hsa002321.80884627
27Chemical carcinogenesis_Homo sapiens_hsa052041.75701576
28Propanoate metabolism_Homo sapiens_hsa006401.74372845
29Butanoate metabolism_Homo sapiens_hsa006501.73630466
30Circadian rhythm_Homo sapiens_hsa047101.73527075
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67907009
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.63622919
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.62455508
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60035437
35Phototransduction_Homo sapiens_hsa047441.55098320
36Retinol metabolism_Homo sapiens_hsa008301.52826131
37beta-Alanine metabolism_Homo sapiens_hsa004101.51678717
38Calcium signaling pathway_Homo sapiens_hsa040201.50111152
39Bile secretion_Homo sapiens_hsa049761.45377733
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45138024
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37977610
42Starch and sucrose metabolism_Homo sapiens_hsa005001.34331934
43Histidine metabolism_Homo sapiens_hsa003401.33930559
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31046766
45Pyruvate metabolism_Homo sapiens_hsa006201.27197766
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.24581126
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.23695147
48Ovarian steroidogenesis_Homo sapiens_hsa049131.22479855
49Carbon metabolism_Homo sapiens_hsa012001.21594879
50Biosynthesis of amino acids_Homo sapiens_hsa012301.16995003
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14746701
52Lysine degradation_Homo sapiens_hsa003101.14668800
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14286070
54Phenylalanine metabolism_Homo sapiens_hsa003601.13935719
55ABC transporters_Homo sapiens_hsa020101.12084457
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04310593
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.03220938
58Oxytocin signaling pathway_Homo sapiens_hsa049211.02451128
59Sulfur metabolism_Homo sapiens_hsa009200.99923570
60Ether lipid metabolism_Homo sapiens_hsa005650.98494498
61One carbon pool by folate_Homo sapiens_hsa006700.96377759
62Insulin secretion_Homo sapiens_hsa049110.95729084
63Regulation of autophagy_Homo sapiens_hsa041400.93909003
64Salivary secretion_Homo sapiens_hsa049700.92403064
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91282481
66Glucagon signaling pathway_Homo sapiens_hsa049220.90612448
67Vitamin digestion and absorption_Homo sapiens_hsa049770.90517197
68Tyrosine metabolism_Homo sapiens_hsa003500.88126093
69Pentose phosphate pathway_Homo sapiens_hsa000300.88052337
70Fat digestion and absorption_Homo sapiens_hsa049750.87020502
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86674079
72Glutathione metabolism_Homo sapiens_hsa004800.86667059
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84299469
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83484285
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82510624
76Folate biosynthesis_Homo sapiens_hsa007900.81876767
77Renin secretion_Homo sapiens_hsa049240.80418254
78Steroid biosynthesis_Homo sapiens_hsa001000.77981780
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75836944
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73144274
81Fatty acid biosynthesis_Homo sapiens_hsa000610.72498151
82Arachidonic acid metabolism_Homo sapiens_hsa005900.72151743
83Fatty acid elongation_Homo sapiens_hsa000620.70742254
84Sulfur relay system_Homo sapiens_hsa041220.70447729
85Arginine and proline metabolism_Homo sapiens_hsa003300.69302998
86Platelet activation_Homo sapiens_hsa046110.65416709
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.64801790
88Glycerolipid metabolism_Homo sapiens_hsa005610.63535118
89Taste transduction_Homo sapiens_hsa047420.60513219
90Gastric acid secretion_Homo sapiens_hsa049710.59961721
91Serotonergic synapse_Homo sapiens_hsa047260.57816164
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56981068
93Insulin resistance_Homo sapiens_hsa049310.53615032
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.52488393
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.52107610
96Circadian entrainment_Homo sapiens_hsa047130.51700268
97Mineral absorption_Homo sapiens_hsa049780.51190783
98Olfactory transduction_Homo sapiens_hsa047400.48964106
99Legionellosis_Homo sapiens_hsa051340.48872328
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48702197
101Prion diseases_Homo sapiens_hsa050200.47409567
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46664068
103Insulin signaling pathway_Homo sapiens_hsa049100.45048531
104Leishmaniasis_Homo sapiens_hsa051400.43124043
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42880128
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42456489
107African trypanosomiasis_Homo sapiens_hsa051430.41688701
108Morphine addiction_Homo sapiens_hsa050320.40636026
109cAMP signaling pathway_Homo sapiens_hsa040240.40437886
110Vitamin B6 metabolism_Homo sapiens_hsa007500.40330915
111FoxO signaling pathway_Homo sapiens_hsa040680.39808918
112Long-term depression_Homo sapiens_hsa047300.39270256
113Systemic lupus erythematosus_Homo sapiens_hsa053220.39012302
114MAPK signaling pathway_Homo sapiens_hsa040100.38921725
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38921428
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38451381
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38375703
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38215583
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37394567
120Non-small cell lung cancer_Homo sapiens_hsa052230.36862164
121Dorso-ventral axis formation_Homo sapiens_hsa043200.34516710
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.32782081
123Amoebiasis_Homo sapiens_hsa051460.30965544
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.30962006
125Bladder cancer_Homo sapiens_hsa052190.30956930
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30545263
127Pertussis_Homo sapiens_hsa051330.29319537
128Small cell lung cancer_Homo sapiens_hsa052220.28165433
129Toxoplasmosis_Homo sapiens_hsa051450.25623070
130Malaria_Homo sapiens_hsa051440.25098385
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24200045
132Hepatitis C_Homo sapiens_hsa051600.22527084
133Osteoclast differentiation_Homo sapiens_hsa043800.22442383
134Lysosome_Homo sapiens_hsa041420.22185140
135Fructose and mannose metabolism_Homo sapiens_hsa000510.19961061
136Apoptosis_Homo sapiens_hsa042100.18007989
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17527157
138Chronic myeloid leukemia_Homo sapiens_hsa052200.17287380
139Galactose metabolism_Homo sapiens_hsa000520.16624968
140Antigen processing and presentation_Homo sapiens_hsa046120.16186529
141Metabolic pathways_Homo sapiens_hsa011000.15639435
142NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15556182
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13988007
144TNF signaling pathway_Homo sapiens_hsa046680.13154647
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.12777410
146AMPK signaling pathway_Homo sapiens_hsa041520.12129098
147RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10501557
148Leukocyte transendothelial migration_Homo sapiens_hsa046700.10378432
149Proteoglycans in cancer_Homo sapiens_hsa052050.09606868
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09007614

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