ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis (GO:0007140)	9.82499157
2	regulation of meiosis I (GO:0060631)	9.00727571
3	meiotic nuclear division (GO:0007126)	8.55085608
4	chromosome organization involved in meiosis (GO:0070192)	8.55055526
5	male meiosis I (GO:0007141)	7.81977654
6	histone H3-K9 demethylation (GO:0033169)	7.27917756
7	meiotic chromosome segregation (GO:0045132)	6.65121100
8	meiosis I (GO:0007127)	6.61481663
9	gene silencing by RNA (GO:0031047)	6.44328544
10	meiotic cell cycle process (GO:1903046)	6.15972449
11	histone H3-K36 demethylation (GO:0070544)	6.14122878
12	DNA alkylation (GO:0006305)	6.08082563
13	DNA methylation (GO:0006306)	6.08082563
14	positive regulation of meiosis (GO:0045836)	5.82481734
15	reciprocal meiotic recombination (GO:0007131)	5.73167420
16	reciprocal DNA recombination (GO:0035825)	5.73167420
17	oogenesis (GO:0048477)	5.61172152
18	positive regulation of meiotic cell cycle (GO:0051446)	5.45277286
19	DNA synthesis involved in DNA repair (GO:0000731)	5.32213041
20	negative regulation of meiosis (GO:0045835)	5.31512251
21	attachment of spindle microtubules to kinetochore (GO:0008608)	5.28623240
22	positive regulation of translational initiation (GO:0045948)	5.04540170
23	positive regulation of cellular response to oxidative stress (GO:1900409)	4.94776468
24	positive regulation of response to oxidative stress (GO:1902884)	4.94776468
25	resolution of meiotic recombination intermediates (GO:0000712)	4.93702015
26	sister chromatid cohesion (GO:0007062)	4.89607273
27	nuclear pore complex assembly (GO:0051292)	4.77545271
28	nuclear pore organization (GO:0006999)	4.77484448
29	oocyte maturation (GO:0001556)	4.75788425
30	DNA replication checkpoint (GO:0000076)	4.71160327
31	female gamete generation (GO:0007292)	4.69352521
32	DNA methylation or demethylation (GO:0044728)	4.69186699
33	gene silencing (GO:0016458)	4.51423630
34	mitotic chromosome condensation (GO:0007076)	4.40394743
35	regulation of meiosis (GO:0040020)	4.39208217
36	heterochromatin organization (GO:0070828)	4.33342226
37	kinetochore organization (GO:0051383)	4.32561486
38	regulation of DNA endoreduplication (GO:0032875)	4.29258557
39	meiotic cell cycle (GO:0051321)	4.27095375
40	negative regulation of gene silencing (GO:0060969)	4.20004298
41	synapsis (GO:0007129)	4.15184322
42	oocyte development (GO:0048599)	4.13781909
43	kinetochore assembly (GO:0051382)	4.06863314
44	chromatin remodeling at centromere (GO:0031055)	4.04665524
45	regulation of double-strand break repair via homologous recombination (GO:0010569)	4.00062025
46	DNA modification (GO:0006304)	3.96262803
47	protein K6-linked ubiquitination (GO:0085020)	3.94982275
48	regulation of transcription from RNA polymerase I promoter (GO:0006356)	3.91864316
49	proteasome assembly (GO:0043248)	3.89977919
50	histone exchange (GO:0043486)	3.87481828
51	DNA replication-dependent nucleosome organization (GO:0034723)	3.85631204
52	DNA replication-dependent nucleosome assembly (GO:0006335)	3.85631204
53	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	3.77040471
54	germ cell development (GO:0007281)	3.65300723
55	mitotic metaphase plate congression (GO:0007080)	3.64717770
56	regulation of meiotic cell cycle (GO:0051445)	3.54405500
57	metaphase plate congression (GO:0051310)	3.54370968
58	histone lysine demethylation (GO:0070076)	3.53967105
59	pore complex assembly (GO:0046931)	3.49269814
60	negative regulation of meiotic cell cycle (GO:0051447)	3.48633164
61	chromosome organization (GO:0051276)	3.48306711
62	DNA biosynthetic process (GO:0071897)	3.45907874
63	histone demethylation (GO:0016577)	3.44648671
64	embryonic body morphogenesis (GO:0010172)	3.44626258
65	regulation of histone H3-K9 methylation (GO:0051570)	3.43330249
66	DNA replication-independent nucleosome organization (GO:0034724)	3.43128244
67	DNA replication-independent nucleosome assembly (GO:0006336)	3.43128244
68	male gamete generation (GO:0048232)	3.43075773
69	nuclear division (GO:0000280)	3.42982763
70	spermatogenesis (GO:0007283)	3.42824884
71	regulation of chromosome segregation (GO:0051983)	3.39541784
72	negative regulation of inclusion body assembly (GO:0090084)	3.38901204
73	histone H2A acetylation (GO:0043968)	3.36419608
74	CENP-A containing nucleosome assembly (GO:0034080)	3.34894221
75	mitotic spindle assembly checkpoint (GO:0007094)	3.33629535
76	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.33077670
77	mitotic spindle checkpoint (GO:0071174)	3.31529052
78	sex differentiation (GO:0007548)	3.29053907
79	negative regulation of chromosome segregation (GO:0051985)	3.27974590
80	spindle assembly checkpoint (GO:0071173)	3.27833298
81	gamete generation (GO:0007276)	3.27492442
82	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.25707800
83	negative regulation of sister chromatid segregation (GO:0033046)	3.25707800
84	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.25707800
85	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.25707800
86	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.24007180
87	spindle checkpoint (GO:0031577)	3.21656870
88	reproductive system development (GO:0061458)	3.20125402
89	protein dealkylation (GO:0008214)	3.18415247
90	protein demethylation (GO:0006482)	3.18415247
91	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.18140292
92	negative regulation of nuclear division (GO:0051784)	3.15938067
93	organelle fission (GO:0048285)	3.14679116
94	genitalia morphogenesis (GO:0035112)	3.12711032
95	regulation of double-strand break repair (GO:2000779)	3.12264359
96	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.09613814
97	regulation of sister chromatid segregation (GO:0033045)	3.08957849
98	regulation of mitotic sister chromatid separation (GO:0010965)	3.08957849
99	regulation of mitotic sister chromatid segregation (GO:0033047)	3.08957849
100	fertilization (GO:0009566)	3.08943210
101	DNA packaging (GO:0006323)	3.08584785
102	monoubiquitinated protein deubiquitination (GO:0035520)	3.06587371
103	mitotic nuclear envelope disassembly (GO:0007077)	3.04540902
104	chromosome segregation (GO:0007059)	3.04531492
105	negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)	3.02501162
106	spermatid development (GO:0007286)	3.02495875
107	histone H4-K16 acetylation (GO:0043984)	3.02434005
108	mitotic sister chromatid cohesion (GO:0007064)	3.01615743
109	histone H4-K12 acetylation (GO:0043983)	3.01005757
110	microtubule depolymerization (GO:0007019)	2.99931596
111	protein localization to chromosome (GO:0034502)	2.99690424
112	binding of sperm to zona pellucida (GO:0007339)	2.98178961
113	regulation of centriole replication (GO:0046599)	2.96043766
114	chromatin assembly or disassembly (GO:0006333)	2.91796003
115	body morphogenesis (GO:0010171)	2.91005565
116	membrane disassembly (GO:0030397)	2.90488487
117	nuclear envelope disassembly (GO:0051081)	2.90488487
118	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.89832862
119	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.88193892
120	mRNA export from nucleus (GO:0006406)	2.85878849
121	histone H4-K5 acetylation (GO:0043981)	2.84020325
122	histone H4-K8 acetylation (GO:0043982)	2.84020325
123	interkinetic nuclear migration (GO:0022027)	2.77403871
124	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.68058289
125	regulation of female receptivity (GO:0045924)	2.67508119
126	protein maturation by protein folding (GO:0022417)	2.66916736
127	sperm-egg recognition (GO:0035036)	2.66884746
128	protein refolding (GO:0042026)	2.59719584
129	piRNA metabolic process (GO:0034587)	16.2090756
130	DNA methylation involved in gamete generation (GO:0043046)	12.7554366
131	synaptonemal complex assembly (GO:0007130)	12.3809906
132	synaptonemal complex organization (GO:0070193)	11.5320689

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	8.79920979
2	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	6.76253615
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.51902986
4	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.65549138
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.95277562
6	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.54670384
7	AR_21909140_ChIP-Seq_LNCAP_Human	3.23682037
8	IGF1R_20145208_ChIP-Seq_DFB_Human	3.20644605
9	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	3.12027606
10	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.09849849
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.98752600
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.70254670
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.50837454
14	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.45307715
15	MYCN_18555785_ChIP-Seq_MESCs_Mouse	2.39635254
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.25958567
17	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.23313335
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.21968659
19	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.21763651
20	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.18944590
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.17164705
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.12389658
23	ZNF274_21170338_ChIP-Seq_K562_Hela	2.02514361
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.01914861
25	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.88633681
26	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.87940181
27	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.84735851
28	RNF2_27304074_Chip-Seq_NSC_Mouse	1.83547372
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.81294887
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.80636413
31	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.78185579
32	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.78185579
33	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.78185579
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.78169915
35	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.75079292
36	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.66200175
37	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.66038987
38	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.61080370
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.59581525
40	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.59013814
41	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.57796310
42	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.56036288
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.55022231
44	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.53416050
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.53224685
46	DCP1A_22483619_ChIP-Seq_HELA_Human	1.53027890
47	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.49070114
48	* RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.47872423
49	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.47256761
50	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.47177154
51	ER_23166858_ChIP-Seq_MCF-7_Human	1.44847630
52	XRN2_22483619_ChIP-Seq_HELA_Human	1.43870433
53	GABP_19822575_ChIP-Seq_HepG2_Human	1.40528338
54	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.40246239
55	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.39873921
56	ERA_21632823_ChIP-Seq_H3396_Human	1.37858098
57	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.34481531
58	KDM5A_27292631_Chip-Seq_BREAST_Human	1.32960028
59	* RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.29879614
60	FOXP3_21729870_ChIP-Seq_TREG_Human	1.27749787
61	GATA3_26560356_Chip-Seq_TH1_Human	1.23056468
62	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.22953323
63	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.22070152
64	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21527817
65	TTF2_22483619_ChIP-Seq_HELA_Human	1.18835910
66	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.16068508
67	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.14261430
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.09010358
69	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.06875965
70	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.06803535
71	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.05840748
72	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.02238540
73	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.99762404
74	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.99378395
75	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.96791983
76	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.96452196
77	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.95021606
78	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.94707683
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93733969
80	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.92505978
81	TAF15_26573619_Chip-Seq_HEK293_Human	0.91780901
82	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.91574492
83	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90929677
84	* RUNX2_22187159_ChIP-Seq_PCA_Human	0.90632015
85	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.90302758
86	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.90013074
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.89865564
88	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.89440144
89	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.89299184
90	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.88417892
91	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.88366279
92	PHF8_20622854_ChIP-Seq_HELA_Human	0.88167999
93	SMC4_20622854_ChIP-Seq_HELA_Human	0.87387522
94	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.87130544
95	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.86032759
96	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.85781013
97	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.85668215
98	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.85639794
99	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.85634801
100	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.85068987
101	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.84254419
102	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.83322764
103	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.83308742
104	ELK1_19687146_ChIP-ChIP_HELA_Human	0.82594534
105	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.81551452
106	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.81184777
107	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.81137588
108	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.81081132
109	FUS_26573619_Chip-Seq_HEK293_Human	0.80649518
110	EWS_26573619_Chip-Seq_HEK293_Human	0.80551935
111	* MYC_18940864_ChIP-ChIP_HL60_Human	0.80143596
112	PHF8_20622853_ChIP-Seq_HELA_Human	0.79966544
113	HTT_18923047_ChIP-ChIP_STHdh_Human	0.79076112
114	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.77869859
115	STAT3_23295773_ChIP-Seq_U87_Human	0.77299720
116	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.77293294
117	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.77214470
118	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.77129210
119	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.76227231
120	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.76136766
121	TFEB_21752829_ChIP-Seq_HELA_Human	0.75352260
122	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.75216721
123	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.75100005
124	* SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.73026058
125	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.72367855
126	CIITA_25753668_ChIP-Seq_RAJI_Human	0.72064862
127	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.71012629
128	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.69981963
129	HOXB7_26014856_ChIP-Seq_BT474_Human	0.69229396
130	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.68233274
131	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.67645462
132	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.63354139
133	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.62394887
134	ETV1_20927104_ChIP-Seq_GIST48_Human	0.62104076
135	CDX2_22108803_ChIP-Seq_LS180_Human	0.62095929
136	OCT4_19829295_ChIP-Seq_ESCs_Human	0.60633242
137	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.60550501
138	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.60423454
139	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.59278183
140	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.59170462
141	RBPJ_21746931_ChIP-Seq_IB4_Human	0.58911654
142	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.58894274

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008995_early_reproductive_senescence	5.85858748
2	* MP0002210_abnormal_sex_determination	4.59359698
3	MP0010094_abnormal_chromosome_stability	4.14011077
4	* MP0001929_abnormal_gametogenesis	4.08816463
5	MP0003786_premature_aging	3.97175746
6	MP0008058_abnormal_DNA_repair	3.73290647
7	* MP0001145_abnormal_male_reproductive	3.60961735
8	* MP0000653_abnormal_sex_gland	3.40588070
9	MP0008057_abnormal_DNA_replication	3.39493845
10	MP0003123_paternal_imprinting	3.34599839
11	* MP0003698_abnormal_male_reproductive	3.20363468
12	MP0003111_abnormal_nucleus_morphology	3.05816802
13	MP0000678_abnormal_parathyroid_gland	2.84545227
14	MP0003693_abnormal_embryo_hatching	2.84079245
15	MP0003077_abnormal_cell_cycle	2.57943751
16	MP0004957_abnormal_blastocyst_morpholog	2.50942172
17	MP0005410_abnormal_fertilization	2.24564540
18	MP0008004_abnormal_stomach_pH	2.18216078
19	* MP0002161_abnormal_fertility/fecundity	2.02052529
20	MP0008877_abnormal_DNA_methylation	11.1547995
21	MP0001119_abnormal_female_reproductive	1.98401245
22	MP0008007_abnormal_cellular_replicative	1.87228578
23	MP0003718_maternal_effect	1.75974780
24	MP0008932_abnormal_embryonic_tissue	1.72986044
25	MP0003121_genomic_imprinting	1.70180970
26	MP0001730_embryonic_growth_arrest	1.63322381
27	MP0008789_abnormal_olfactory_epithelium	1.55880889
28	MP0003699_abnormal_female_reproductive	1.53001101
29	MP0003890_abnormal_embryonic-extraembry	1.39705897
30	MP0002160_abnormal_reproductive_system	1.39562503
31	MP0000350_abnormal_cell_proliferation	1.39363497
32	MP0004808_abnormal_hematopoietic_stem	1.31569065
33	MP0003787_abnormal_imprinting	1.20671118
34	MP0006035_abnormal_mitochondrial_morpho	1.19439244
35	MP0001188_hyperpigmentation	1.17654743
36	MP0010352_gastrointestinal_tract_polyps	1.17085650
37	MP0010307_abnormal_tumor_latency	1.16137268
38	MP0000015_abnormal_ear_pigmentation	1.09078774
39	MP0005647_abnormal_sex_gland	1.06141170
40	MP0005058_abnormal_lysosome_morphology	1.06035346
41	MP0001697_abnormal_embryo_size	1.03511066
42	MP0005174_abnormal_tail_pigmentation	1.03059197
43	MP0003183_abnormal_peptide_metabolism	1.01654154
44	MP0005380_embryogenesis_phenotype	0.98265847
45	MP0001672_abnormal_embryogenesis/_devel	0.98265847
46	MP0002085_abnormal_embryonic_tissue	0.97998428
47	MP0005394_taste/olfaction_phenotype	0.97465037
48	MP0005499_abnormal_olfactory_system	0.97465037
49	MP0005409_darkened_coat_color	0.94280803
50	MP0003315_abnormal_perineum_morphology	0.93418000
51	MP0000313_abnormal_cell_death	0.91995423
52	MP0000013_abnormal_adipose_tissue	0.88187558
53	MP0005389_reproductive_system_phenotype	0.87675460
54	MP0002084_abnormal_developmental_patter	0.87594851
55	MP0009672_abnormal_birth_weight	0.86837871
56	MP0003984_embryonic_growth_retardation	0.85281338
57	MP0004197_abnormal_fetal_growth/weight/	0.85086123
58	MP0009379_abnormal_foot_pigmentation	0.84188541
59	MP0003878_abnormal_ear_physiology	0.83537408
60	MP0005377_hearing/vestibular/ear_phenot	0.83537408
61	MP0002019_abnormal_tumor_incidence	0.82998361
62	MP0001984_abnormal_olfaction	0.82211984
63	MP0003646_muscle_fatigue	0.79735515
64	MP0002088_abnormal_embryonic_growth/wei	0.79123362
65	MP0002249_abnormal_larynx_morphology	0.78279307
66	MP0002080_prenatal_lethality	0.75734759
67	MP0006036_abnormal_mitochondrial_physio	0.73507959
68	MP0003936_abnormal_reproductive_system	0.72168115
69	MP0003941_abnormal_skin_development	0.72131068
70	MP0010030_abnormal_orbit_morphology	0.70876612
71	MP0001661_extended_life_span	0.69996426
72	MP0005623_abnormal_meninges_morphology	0.68242081
73	MP0000358_abnormal_cell_content/	0.68008226
74	MP0005423_abnormal_somatic_nervous	0.67710123
75	MP0003943_abnormal_hepatobiliary_system	0.66944537
76	MP0005395_other_phenotype	0.66391969
77	MP0005076_abnormal_cell_differentiation	0.66021417
78	MP0003938_abnormal_ear_development	0.65235296
79	MP0005451_abnormal_body_composition	0.64982616
80	MP0002653_abnormal_ependyma_morphology	0.64288506
81	MP0000427_abnormal_hair_cycle	0.63238101
82	MP0002086_abnormal_extraembryonic_tissu	0.62015305
83	MP0003937_abnormal_limbs/digits/tail_de	0.58889494
84	MP0001915_intracranial_hemorrhage	0.56005670
85	MP0000778_abnormal_nervous_system	0.54493403
86	MP0004019_abnormal_vitamin_homeostasis	0.53263679
87	MP0001243_abnormal_dermal_layer	0.53151971
88	MP0009703_decreased_birth_body	0.51910435
89	MP0009697_abnormal_copulation	0.51368530
90	MP0003119_abnormal_digestive_system	0.50244952
91	MP0005621_abnormal_cell_physiology	0.50179001
92	MP0002095_abnormal_skin_pigmentation	0.49283373
93	MP0002971_abnormal_brown_adipose	0.49243627
94	MP0005384_cellular_phenotype	0.47447216
95	MP0001299_abnormal_eye_distance/	0.46282844
96	MP0004036_abnormal_muscle_relaxation	0.45679544
97	MP0001986_abnormal_taste_sensitivity	0.45366227
98	MP0010368_abnormal_lymphatic_system	0.44866127
99	MP0001293_anophthalmia	0.44753728
100	MP0006292_abnormal_olfactory_placode	0.43515424
101	MP0001502_abnormal_circadian_rhythm	0.42481068
102	MP0002269_muscular_atrophy	0.42253624
103	MP0008260_abnormal_autophagy	0.42014587
104	MP0002116_abnormal_craniofacial_bone	0.41737533
105	MP0002282_abnormal_trachea_morphology	0.40347488
106	MP0003861_abnormal_nervous_system	0.39311763
107	MP0009250_abnormal_appendicular_skeleto	0.38994037
108	MP0003221_abnormal_cardiomyocyte_apopto	0.38782448
109	MP0000647_abnormal_sebaceous_gland	0.35150918
110	MP0000631_abnormal_neuroendocrine_gland	0.35032430
111	MP0002114_abnormal_axial_skeleton	0.34900962
112	MP0003567_abnormal_fetal_cardiomyocyte	0.34622441
113	MP0003115_abnormal_respiratory_system	0.32939472
114	MP0004185_abnormal_adipocyte_glucose	0.32210558
115	MP0002108_abnormal_muscle_morphology	0.31684792
116	MP0002396_abnormal_hematopoietic_system	0.29142470
117	MP0000579_abnormal_nail_morphology	0.28392431
118	MP0000703_abnormal_thymus_morphology	0.28215681
119	MP0001919_abnormal_reproductive_system	0.28170553
120	MP0003632_abnormal_nervous_system	0.27884541
121	MP0001177_atelectasis	0.27855409
122	MP0002092_abnormal_eye_morphology	0.27139310
123	MP0000516_abnormal_urinary_system	0.26324816
124	MP0005367_renal/urinary_system_phenotyp	0.26324816
125	MP0000383_abnormal_hair_follicle	0.26081921
126	MP0003755_abnormal_palate_morphology	0.26014755
127	MP0000432_abnormal_head_morphology	0.25699129
128	MP0002233_abnormal_nose_morphology	0.25502676
129	MP0001849_ear_inflammation	0.24328543
130	MP0000537_abnormal_urethra_morphology	0.24107371
131	MP0000613_abnormal_salivary_gland	0.24014362
132	MP0000569_abnormal_digit_pigmentation	0.23656608
133	MP0003705_abnormal_hypodermis_morpholog	0.22947274
134	MP0002139_abnormal_hepatobiliary_system	0.22924926
135	MP0002075_abnormal_coat/hair_pigmentati	0.22879175
136	MP0004233_abnormal_muscle_weight	0.22357219
137	MP0005266_abnormal_metabolism	0.21966943
138	MP0010678_abnormal_skin_adnexa	0.21873102
139	MP0001727_abnormal_embryo_implantation	0.21599668
140	MP0006072_abnormal_retinal_apoptosis	0.21335577

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal spermatogenesis (HP:0008669)	9.49077112
2	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	5.54084394
3	Degeneration of the lateral corticospinal tracts (HP:0002314)	5.54084394
4	Abnormality of the lower motor neuron (HP:0002366)	5.47981483
5	Gonadotropin excess (HP:0000837)	5.03812494
6	Chromsome breakage (HP:0040012)	4.81631694
7	Tubulointerstitial nephritis (HP:0001970)	4.62149714
8	Short nail (HP:0001799)	4.20715843
9	Abnormality of the corticospinal tract (HP:0002492)	4.15295845
10	Abnormality of the labia minora (HP:0012880)	4.12422311
11	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.10920681
12	Facial hemangioma (HP:0000329)	4.08628071
13	Horizontal nystagmus (HP:0000666)	4.06999183
14	Broad distal phalanx of finger (HP:0009836)	3.88572171
15	Papillary thyroid carcinoma (HP:0002895)	3.72446189
16	Rimmed vacuoles (HP:0003805)	3.70957209
17	Birth length less than 3rd percentile (HP:0003561)	3.65264354
18	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.61794226
19	Breast hypoplasia (HP:0003187)	3.54260004
20	Spontaneous abortion (HP:0005268)	3.51139063
21	Male infertility (HP:0003251)	3.43048631
22	Carpal bone hypoplasia (HP:0001498)	3.39734349
23	Shoulder girdle muscle weakness (HP:0003547)	3.37804093
24	Amyotrophic lateral sclerosis (HP:0007354)	3.31315767
25	Supernumerary spleens (HP:0009799)	3.26662471
26	Impulsivity (HP:0100710)	3.24089786
27	Impaired vibration sensation in the lower limbs (HP:0002166)	3.18969589
28	Abnormality of chromosome stability (HP:0003220)	3.16239622
29	Upper motor neuron abnormality (HP:0002127)	3.15632986
30	Capillary hemangiomas (HP:0005306)	3.07671637
31	Hyperpituitarism (HP:0010514)	3.04521170
32	Ectopic kidney (HP:0000086)	3.00195608
33	Large hands (HP:0001176)	2.96866298
34	11 pairs of ribs (HP:0000878)	2.90618946
35	Peripheral hypomyelination (HP:0007182)	2.89415074
36	Type I transferrin isoform profile (HP:0003642)	2.88799815
37	Ankle contracture (HP:0006466)	2.88337464
38	Oligodactyly (hands) (HP:0001180)	2.84894338
39	Abnormal glycosylation (HP:0012345)	2.81534553
40	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.81534553
41	Abnormal protein N-linked glycosylation (HP:0012347)	2.81534553
42	Abnormal protein glycosylation (HP:0012346)	2.81534553
43	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.71030676
44	Vertebral arch anomaly (HP:0008438)	2.69831685
45	Infertility (HP:0000789)	2.68976961
46	Resting tremor (HP:0002322)	2.66981838
47	Absent radius (HP:0003974)	2.60838146
48	Shawl scrotum (HP:0000049)	2.60273255
49	Absent thumb (HP:0009777)	2.60093401
50	Patellar aplasia (HP:0006443)	2.59725022
51	Abnormality of DNA repair (HP:0003254)	2.58354673
52	Oligodactyly (HP:0012165)	2.56803926
53	Fibular hypoplasia (HP:0003038)	2.55239378
54	Selective tooth agenesis (HP:0001592)	2.55047014
55	Abnormality of the anterior horn cell (HP:0006802)	2.52662533
56	Degeneration of anterior horn cells (HP:0002398)	2.52662533
57	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.51012412
58	Absent/shortened dynein arms (HP:0200106)	2.51012412
59	Progressive external ophthalmoplegia (HP:0000590)	2.50932474
60	Absent forearm bone (HP:0003953)	2.50868555
61	Aplasia involving forearm bones (HP:0009822)	2.50868555
62	Rhabdomyosarcoma (HP:0002859)	2.49677216
63	Meckel diverticulum (HP:0002245)	2.48032266
64	Scotoma (HP:0000575)	2.47293757
65	Bundle branch block (HP:0011710)	2.44922813
66	Sandal gap (HP:0001852)	2.44798748
67	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.44253970
68	Short tibia (HP:0005736)	2.42500372
69	Pelvic girdle muscle weakness (HP:0003749)	2.36584990
70	Menstrual irregularities (HP:0000858)	2.35867446
71	Premature ovarian failure (HP:0008209)	2.35753340
72	Facial cleft (HP:0002006)	2.35293144
73	Aplasia/Hypoplasia of the patella (HP:0006498)	2.34005206
74	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.33258186
75	Abnormality of alanine metabolism (HP:0010916)	2.33258186
76	Hyperalaninemia (HP:0003348)	2.33258186
77	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.32431738
78	Short thumb (HP:0009778)	2.31520214
79	Non-midline cleft lip (HP:0100335)	2.31100261
80	Abnormal lung lobation (HP:0002101)	2.31016525
81	Duplicated collecting system (HP:0000081)	2.27661212
82	Thyroid carcinoma (HP:0002890)	2.26915457
83	Abnormal respiratory motile cilium physiology (HP:0012261)	2.25726121
84	Abnormality of the ileum (HP:0001549)	2.25344837
85	Colon cancer (HP:0003003)	2.24092633
86	Hypoplastic iliac wings (HP:0002866)	2.23699777
87	Wrist flexion contracture (HP:0001239)	2.21355325
88	Horseshoe kidney (HP:0000085)	2.19799432
89	Abnormality of the preputium (HP:0100587)	2.19549670
90	Small intestinal stenosis (HP:0012848)	2.17493846
91	Duodenal stenosis (HP:0100867)	2.17493846
92	Urinary urgency (HP:0000012)	2.15290821
93	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.14914030
94	Spastic gait (HP:0002064)	2.14559818
95	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.10909865
96	Lip pit (HP:0100267)	2.04949078
97	Rhinitis (HP:0012384)	2.04624778
98	Impaired vibratory sensation (HP:0002495)	2.04611431
99	Abnormal biliary tract morphology (HP:0012440)	2.03384657
100	Medulloblastoma (HP:0002885)	2.02667833
101	Abnormality of chromosome segregation (HP:0002916)	2.02030856
102	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.01715631
103	Chronic bronchitis (HP:0004469)	2.00760689
104	Nephroblastoma (Wilms tumor) (HP:0002667)	2.00414621
105	Hand muscle atrophy (HP:0009130)	2.00288896
106	Limb-girdle muscle weakness (HP:0003325)	2.00013678
107	Azoospermia (HP:0000027)	10.7697854
108	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.98496054
109	Abnormality of the hip-girdle musculature (HP:0001445)	1.96485339
110	Abnormality of the musculature of the pelvis (HP:0001469)	1.96485339
111	Decreased subcutaneous fat (HP:0001002)	1.95842855
112	Abnormality of the renal medulla (HP:0100957)	1.94774823
113	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.93764807
114	Osteomalacia (HP:0002749)	1.93424501
115	Breast carcinoma (HP:0003002)	1.92567414
116	Tubulointerstitial abnormality (HP:0001969)	1.90779821
117	Abnormality of the dental root (HP:0006486)	1.90110587
118	Taurodontia (HP:0000679)	1.90110587
119	Abnormality of permanent molar morphology (HP:0011071)	1.90110587
120	Metaphyseal cupping (HP:0003021)	1.89687255
121	Nephronophthisis (HP:0000090)	1.89669160
122	Abnormality of dentin (HP:0010299)	1.86393871
123	Neoplasm of striated muscle (HP:0009728)	1.84769940
124	Ependymoma (HP:0002888)	1.84154143
125	Abnormality of cochlea (HP:0000375)	1.83156150
126	Abnormality of the renal collecting system (HP:0004742)	1.83085401
127	Long foot (HP:0001833)	1.82468910
128	Abnormality of lateral ventricle (HP:0030047)	1.82237785
129	Medial flaring of the eyebrow (HP:0010747)	1.81769258
130	Embryonal renal neoplasm (HP:0011794)	1.81692440
131	Cafe-au-lait spot (HP:0000957)	1.81497664
132	Missing ribs (HP:0000921)	1.81177291
133	Intellectual disability, profound (HP:0002187)	1.80189857
134	Proximal placement of thumb (HP:0009623)	1.79979898
135	Anteriorly placed anus (HP:0001545)	1.78052679
136	External ophthalmoplegia (HP:0000544)	1.77415256
137	Volvulus (HP:0002580)	1.77357859
138	Hypergonadotropic hypogonadism (HP:0000815)	1.77155128
139	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.77010486
140	Heterotopia (HP:0002282)	1.76998337
141	Sloping forehead (HP:0000340)	1.75350925
142	Abnormality of the phalanges of the hallux (HP:0010057)	1.75307271
143	Increased nuchal translucency (HP:0010880)	1.75088140
144	Widely spaced teeth (HP:0000687)	1.74431213
145	Abnormality of molar (HP:0011077)	1.72879536
146	Abnormality of molar morphology (HP:0011070)	1.72879536
147	Urinary bladder sphincter dysfunction (HP:0002839)	1.72756945
148	Abnormality of the aortic arch (HP:0012303)	1.72480227
149	Multicystic kidney dysplasia (HP:0000003)	1.71827424
150	Urethral obstruction (HP:0000796)	1.71812782
151	Loss of speech (HP:0002371)	1.70959377
152	Enlarged penis (HP:0000040)	1.69576330
153	Abnormality of the carotid arteries (HP:0005344)	1.68977603
154	Biliary tract neoplasm (HP:0100574)	1.67546253
155	Glioma (HP:0009733)	1.66127355
156	Abnormality of the duodenum (HP:0002246)	1.65709186
157	Truncal obesity (HP:0001956)	1.64634975

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	7.39719945
2	CDK19	7.07804159
3	CDC7	5.95633287
4	MET	4.98949770
5	CDK12	3.70869772
6	MST1R	3.20621181
7	WEE1	2.99779436
8	OXSR1	2.79850905
9	PDK4	2.76672601
10	PDK3	2.76672601
11	CAMK1G	2.76496943
12	NEK2	2.76276300
13	TTK	2.61198131
14	FGR	2.34487603
15	BRSK2	2.27159184
16	BMX	2.23931865
17	PLK1	2.19812796
18	PLK4	2.17894665
19	STK38L	2.17167129
20	NEK1	1.97314223
21	CSF1R	1.81447345
22	PBK	1.81339236
23	NEK9	1.78649939
24	STK16	1.74201165
25	PRKD3	1.69606474
26	BUB1	1.67044049
27	ATR	1.57094441
28	PDK2	1.55610806
29	CHEK1	1.54462025
30	MELK	1.50343498
31	BRSK1	1.47778238
32	CHEK2	1.41930241
33	MAP3K4	1.32176569
34	PLK3	1.31441074
35	BRD4	1.31222173
36	MAP3K6	1.30671400
37	ATM	1.28321172
38	IRAK3	1.26201940
39	CDK8	1.21645984
40	STK3	1.20577785
41	TESK1	1.20074005
42	STK24	1.14554875
43	BMPR1B	1.14070751
44	PDGFRB	1.12277308
45	EIF2AK1	1.09925449
46	CDK7	1.09146537
47	MKNK2	1.05889144
48	AURKB	1.04091964
49	DYRK3	1.03840870
50	PTK2	0.98224771
51	TYRO3	0.96309209
52	CCNB1	0.87476028
53	SRPK1	0.87062072
54	PLK2	0.84666426
55	MAP3K10	0.82359072
56	CDK2	0.80366736
57	BMPR2	0.78856280
58	CDK1	0.77429975
59	IRAK1	0.77372941
60	TGFBR1	0.77230770
61	CDC42BPA	0.74823490
62	CDK4	0.74752232
63	LATS2	0.74609121
64	ZAK	0.74380944
65	LATS1	0.73275226
66	RPS6KB1	0.71139941
67	KSR1	0.70752668
68	PINK1	0.69539039
69	AURKA	0.66487455
70	STK4	0.66064918
71	CASK	0.65831935
72	EGFR	0.64156888
73	MAP3K5	0.64073877
74	MKNK1	0.63159976
75	MAP3K13	0.61172589
76	STK39	0.60421897
77	PASK	0.60370605
78	MAP2K2	0.60053255
79	CDK6	0.59765900
80	PDPK1	0.58894051
81	CDK3	0.58857207
82	CDK9	0.58211573
83	MOS	0.57026610
84	IRAK2	0.56479305
85	MAP3K2	0.56469492
86	KSR2	0.55060410
87	STK11	0.53692306
88	BCR	0.52699373
89	LIMK1	0.51702683
90	SGK1	0.50714862
91	PDK1	0.50084775
92	CDK11A	0.48822297
93	MAP3K9	0.48344915
94	NEK6	0.47366564
95	CLK1	0.45842030
96	PRKDC	0.44430699
97	ICK	0.43957427
98	EIF2AK3	0.43398736
99	PRKCI	0.42971866
100	PKN2	0.42415300
101	WNK1	0.40522156
102	PTK2B	0.39691137
103	MAPK11	0.39259252
104	AKT3	0.37312151
105	ARAF	0.37201605
106	GSK3B	0.36952296
107	MAP3K8	0.36808804
108	MTOR	0.35956805
109	WNK3	0.35915751
110	BRAF	0.34948157
111	CSNK1D	0.34783740
112	MAP2K7	0.34207407
113	CSNK2A2	0.33653519
114	MARK3	0.33536753
115	SCYL2	0.33320459
116	IGF1R	0.32841466
117	DYRK1A	0.32626609
118	MAPK7	0.32497013
119	CSNK1E	0.31724114
120	CSNK2A1	0.30654025
121	MAPK8	0.30443153
122	STK10	0.30204822
123	CSNK1G1	0.29568424
124	TSSK6	0.28178865
125	MAP3K12	0.27402057
126	TAOK1	0.26580325
127	TAOK3	0.26308721
128	WNK4	0.25495069
129	VRK1	0.24747912
130	MAP2K4	0.24152686
131	PRKCZ	0.23857269
132	RET	0.22368239
133	CAMK1	0.21926264
134	NTRK3	0.21667991
135	RAF1	0.21663642
136	MAPK14	0.21635971
137	PNCK	0.21486975
138	STK38	0.21372194
139	PAK4	0.20996814
140	MARK1	0.20141244
141	CDK15	0.17362537
142	TAOK2	0.16999309
143	AKT2	0.16753512
144	CDK5	0.16375561
145	TAF1	0.14979034
146	YES1	0.14607337
147	ROCK1	0.14031246
148	CDK18	0.13399049
149	MAPK1	0.13215417
150	MAPK3	0.11155968

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	5.38820355
2	Basal transcription factors_Homo sapiens_hsa03022	4.93639179
3	Homologous recombination_Homo sapiens_hsa03440	4.32971099
4	DNA replication_Homo sapiens_hsa03030	4.01373270
5	Sulfur relay system_Homo sapiens_hsa04122	3.78929272
6	Mismatch repair_Homo sapiens_hsa03430	3.65014017
7	Cell cycle_Homo sapiens_hsa04110	3.57611927
8	RNA transport_Homo sapiens_hsa03013	3.43233982
9	Fanconi anemia pathway_Homo sapiens_hsa03460	3.10334447
10	mRNA surveillance pathway_Homo sapiens_hsa03015	2.98655601
11	RNA polymerase_Homo sapiens_hsa03020	2.96511456
12	Non-homologous end-joining_Homo sapiens_hsa03450	2.77517209
13	Nucleotide excision repair_Homo sapiens_hsa03420	2.73853516
14	Spliceosome_Homo sapiens_hsa03040	2.48170845
15	Proteasome_Homo sapiens_hsa03050	2.45386495
16	RNA degradation_Homo sapiens_hsa03018	2.41507988
17	Oocyte meiosis_Homo sapiens_hsa04114	2.30798304
18	Base excision repair_Homo sapiens_hsa03410	2.22736645
19	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.80420982
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.78183014
21	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.74796355
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.68436143
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.66551080
24	p53 signaling pathway_Homo sapiens_hsa04115	1.64214185
25	One carbon pool by folate_Homo sapiens_hsa00670	1.62920236
26	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.44738864
27	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.35037120
28	Purine metabolism_Homo sapiens_hsa00230	1.26310652
29	Herpes simplex infection_Homo sapiens_hsa05168	1.19156611
30	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.12188597
31	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.11754360
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.05229813
33	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.96622284
34	Linoleic acid metabolism_Homo sapiens_hsa00591	0.95102617
35	Protein export_Homo sapiens_hsa03060	0.90767448
36	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.90705070
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.86129650
38	ErbB signaling pathway_Homo sapiens_hsa04012	0.84116496
39	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83837531
40	Thyroid cancer_Homo sapiens_hsa05216	0.79532253
41	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.77582513
42	Lysine degradation_Homo sapiens_hsa00310	0.73243143
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71735476
44	Retinol metabolism_Homo sapiens_hsa00830	0.69725343
45	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.67682755
46	Pentose phosphate pathway_Homo sapiens_hsa00030	0.64613900
47	Influenza A_Homo sapiens_hsa05164	0.62587622
48	Choline metabolism in cancer_Homo sapiens_hsa05231	0.62164181
49	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.60882900
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.60001430
51	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58525315
52	Viral carcinogenesis_Homo sapiens_hsa05203	0.58367033
53	Legionellosis_Homo sapiens_hsa05134	0.56885904
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55524392
55	* HTLV-I infection_Homo sapiens_hsa05166	0.52256284
56	MicroRNAs in cancer_Homo sapiens_hsa05206	0.52136098
57	Fatty acid elongation_Homo sapiens_hsa00062	0.52090334
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.50682036
59	Phenylalanine metabolism_Homo sapiens_hsa00360	0.48073256
60	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.48046005
61	Prion diseases_Homo sapiens_hsa05020	0.46860882
62	Pyruvate metabolism_Homo sapiens_hsa00620	0.46408817
63	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.46226981
64	Hippo signaling pathway_Homo sapiens_hsa04390	0.45532732
65	Peroxisome_Homo sapiens_hsa04146	0.41496858
66	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.40572236
67	Circadian rhythm_Homo sapiens_hsa04710	0.40458176
68	Huntingtons disease_Homo sapiens_hsa05016	0.40054819
69	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39454820
70	Pancreatic cancer_Homo sapiens_hsa05212	0.38140357
71	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.37877662
72	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.37653005
73	Adherens junction_Homo sapiens_hsa04520	0.37345467
74	ABC transporters_Homo sapiens_hsa02010	0.35852678
75	FoxO signaling pathway_Homo sapiens_hsa04068	0.34829782
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34728691
77	Endometrial cancer_Homo sapiens_hsa05213	0.33585838
78	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.32493007
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.32343080
80	Tight junction_Homo sapiens_hsa04530	0.31727388
81	Small cell lung cancer_Homo sapiens_hsa05222	0.29776233
82	Glutathione metabolism_Homo sapiens_hsa00480	0.28965360
83	Notch signaling pathway_Homo sapiens_hsa04330	0.27830938
84	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.26846268
85	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.24095221
86	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.22426971
87	MAPK signaling pathway_Homo sapiens_hsa04010	0.20748331
88	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.19867244
89	Endocytosis_Homo sapiens_hsa04144	0.19222550
90	Glucagon signaling pathway_Homo sapiens_hsa04922	0.19104005
91	Antigen processing and presentation_Homo sapiens_hsa04612	0.19046124
92	Amoebiasis_Homo sapiens_hsa05146	0.18841880
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.18023375
94	Colorectal cancer_Homo sapiens_hsa05210	0.17770729
95	Shigellosis_Homo sapiens_hsa05131	0.15149002
96	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.14771534
97	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.13994687
98	Type II diabetes mellitus_Homo sapiens_hsa04930	0.13091711
99	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.12258365
100	Regulation of autophagy_Homo sapiens_hsa04140	0.11949715
101	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.11821777
102	Fat digestion and absorption_Homo sapiens_hsa04975	0.11618391
103	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.10823810
104	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.09463319
105	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.09152594
106	Pathways in cancer_Homo sapiens_hsa05200	0.08176967
107	Apoptosis_Homo sapiens_hsa04210	0.07653298
108	Wnt signaling pathway_Homo sapiens_hsa04310	0.06468356
109	AMPK signaling pathway_Homo sapiens_hsa04152	0.06225252
110	Olfactory transduction_Homo sapiens_hsa04740	0.05879558
111	Protein digestion and absorption_Homo sapiens_hsa04974	0.05263698
112	Propanoate metabolism_Homo sapiens_hsa00640	0.04758834
113	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.04634522
114	Renal cell carcinoma_Homo sapiens_hsa05211	0.04405187
115	Metabolic pathways_Homo sapiens_hsa01100	0.04393382
116	Carbon metabolism_Homo sapiens_hsa01200	0.03933530
117	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.03288928
118	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.02934670
119	Prostate cancer_Homo sapiens_hsa05215	0.02010781
120	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.00843979
121	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.00527973
122	mTOR signaling pathway_Homo sapiens_hsa04150	0.00101875
123	Folate biosynthesis_Homo sapiens_hsa00790	-0.0766274
124	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	-0.0753099
125	Steroid biosynthesis_Homo sapiens_hsa00100	-0.0680734
126	Long-term potentiation_Homo sapiens_hsa04720	-0.0671912
127	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.0640071
128	VEGF signaling pathway_Homo sapiens_hsa04370	-0.0629692
129	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	-0.0624992
130	Vitamin digestion and absorption_Homo sapiens_hsa04977	-0.0436591
131	HIF-1 signaling pathway_Homo sapiens_hsa04066	-0.0427847
132	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	-0.0402550
133	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.0341883
134	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	-0.0119689
135	Basal cell carcinoma_Homo sapiens_hsa05217	-0.0109580
136	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	-0.0036915

SLC25A31

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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