SLC25A32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the P(I/L)W subfamily of mitochondrial carrier family transport proteins. The encoded protein transports folate across the inner mitochondrial membrane. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)4.89809298
2proteasome assembly (GO:0043248)4.67006908
3regulation of translational termination (GO:0006449)4.51495286
4rRNA methylation (GO:0031167)4.21644046
5glycine metabolic process (GO:0006544)4.02334669
6transcription from mitochondrial promoter (GO:0006390)4.00638421
7rRNA modification (GO:0000154)4.00478014
8somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.97932308
9somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.97932308
10isotype switching (GO:0045190)3.97932308
11L-phenylalanine metabolic process (GO:0006558)3.93481667
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.93481667
13serine family amino acid biosynthetic process (GO:0009070)3.90517931
14L-phenylalanine catabolic process (GO:0006559)3.83736861
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.83736861
16cysteine metabolic process (GO:0006534)3.82756492
17maturation of 5.8S rRNA (GO:0000460)3.80517049
18one-carbon metabolic process (GO:0006730)3.74414795
19mitochondrial RNA metabolic process (GO:0000959)3.73035941
20cullin deneddylation (GO:0010388)3.72210059
21protein deneddylation (GO:0000338)3.65875279
22* folic acid metabolic process (GO:0046655)3.65633512
23tRNA aminoacylation for protein translation (GO:0006418)3.65086816
24tRNA aminoacylation (GO:0043039)3.61931438
25amino acid activation (GO:0043038)3.61931438
26tetrahydrofolate metabolic process (GO:0046653)3.61273195
27L-serine metabolic process (GO:0006563)3.59264975
28pore complex assembly (GO:0046931)3.57805602
29pteridine-containing compound biosynthetic process (GO:0042559)3.55990940
30mitotic metaphase plate congression (GO:0007080)3.53533567
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.49909063
32pseudouridine synthesis (GO:0001522)3.47143110
33aromatic amino acid family catabolic process (GO:0009074)3.46782479
34serine family amino acid metabolic process (GO:0009069)3.46110303
35urea cycle (GO:0000050)3.45869874
36urea metabolic process (GO:0019627)3.45869874
37somatic recombination of immunoglobulin gene segments (GO:0016447)3.45074074
38negative regulation of fibrinolysis (GO:0051918)3.41759266
39alpha-linolenic acid metabolic process (GO:0036109)3.33429705
40regulation of centriole replication (GO:0046599)3.31875617
41metaphase plate congression (GO:0051310)3.31643693
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27459835
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.26510002
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.25732982
45somatic diversification of immunoglobulins (GO:0016445)3.22103262
46RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.21926381
47serine family amino acid catabolic process (GO:0009071)3.21489844
48* folic acid-containing compound metabolic process (GO:0006760)3.19094572
49sulfur amino acid catabolic process (GO:0000098)3.18871962
50protein carboxylation (GO:0018214)3.17539158
51peptidyl-glutamic acid carboxylation (GO:0017187)3.17539158
52kynurenine metabolic process (GO:0070189)3.16491510
53nitrogen cycle metabolic process (GO:0071941)3.16386545
54transcription elongation from RNA polymerase I promoter (GO:0006362)3.16029847
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15911673
56protein K6-linked ubiquitination (GO:0085020)3.15146329
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.13380121
58termination of RNA polymerase I transcription (GO:0006363)3.13225994
59DNA double-strand break processing (GO:0000729)3.11574745
60ribonucleoprotein complex disassembly (GO:0032988)3.11479862
61indole-containing compound catabolic process (GO:0042436)3.10425794
62indolalkylamine catabolic process (GO:0046218)3.10425794
63tryptophan catabolic process (GO:0006569)3.10425794
64double-strand break repair via nonhomologous end joining (GO:0006303)3.10136142
65non-recombinational repair (GO:0000726)3.10136142
66lysine catabolic process (GO:0006554)3.08812381
67lysine metabolic process (GO:0006553)3.08812381
68nucleobase biosynthetic process (GO:0046112)3.08631798
69bile acid biosynthetic process (GO:0006699)3.08344743
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05998419
71positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.04911925
72positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.04911925
73positive regulation of mitotic sister chromatid separation (GO:1901970)3.04911925
74regulation of protein activation cascade (GO:2000257)3.03353145
75purine nucleobase biosynthetic process (GO:0009113)3.02844899
76establishment of chromosome localization (GO:0051303)3.02203369
77negative regulation of ligase activity (GO:0051352)3.01274116
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01274116
79valine metabolic process (GO:0006573)3.01088397
80protein localization to chromosome, centromeric region (GO:0071459)3.00200825
81regulation of fibrinolysis (GO:0051917)2.97598290
82tryptophan metabolic process (GO:0006568)2.97290095
83imidazole-containing compound metabolic process (GO:0052803)2.94744903
84nuclear pore complex assembly (GO:0051292)2.94272673
85positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93125099
86regulation of cellular amino acid metabolic process (GO:0006521)2.90892652
87antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.88638217
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.88638217
89rRNA processing (GO:0006364)2.87154652
90COPII vesicle coating (GO:0048208)2.87018893
91peptidyl-histidine modification (GO:0018202)2.86309721
92mitotic nuclear envelope disassembly (GO:0007077)2.85709771
93homocysteine metabolic process (GO:0050667)2.85545594
94organelle disassembly (GO:1903008)2.84159179
95regulation of complement activation (GO:0030449)2.83591033
96transcription initiation from RNA polymerase I promoter (GO:0006361)2.83510305
97nuclear pore organization (GO:0006999)2.83451278
98DNA catabolic process, exonucleolytic (GO:0000738)2.83132511
99intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.82773055
100signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.82773055
101signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82364880
102signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82364880
103signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82364880
104fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.82030652
105* pteridine-containing compound metabolic process (GO:0042558)2.81916959
106deoxyribonucleotide biosynthetic process (GO:0009263)2.80725580
107protein K11-linked ubiquitination (GO:0070979)2.80708129
108regulation of DNA endoreduplication (GO:0032875)2.80600309
109DNA deamination (GO:0045006)2.80048962
110regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.80036775
111regulation of mitotic spindle checkpoint (GO:1903504)2.80036775
112positive regulation of ligase activity (GO:0051351)2.79952379
113response to pheromone (GO:0019236)2.79828173
114DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.79713129
115mitotic sister chromatid cohesion (GO:0007064)2.79645610
116magnesium ion transport (GO:0015693)2.78459920
117complement activation, alternative pathway (GO:0006957)2.78446777
118signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78424854
119signal transduction involved in DNA damage checkpoint (GO:0072422)2.78424854
120tRNA metabolic process (GO:0006399)2.78032235
121amino-acid betaine metabolic process (GO:0006577)2.77872459
122signal transduction involved in cell cycle checkpoint (GO:0072395)2.77740000
123glyoxylate metabolic process (GO:0046487)2.77508473
124nucleobase-containing small molecule interconversion (GO:0015949)2.76955697
125dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.76622540
126rRNA metabolic process (GO:0016072)2.75808495
127high-density lipoprotein particle remodeling (GO:0034375)2.75453355
128ER overload response (GO:0006983)2.75391600
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.74032332
130sulfur amino acid biosynthetic process (GO:0000097)2.73120888
131bile acid metabolic process (GO:0008206)2.72443230
132regulation of mitochondrial translation (GO:0070129)2.72429615
133attachment of spindle microtubules to kinetochore (GO:0008608)2.72345934
1347-methylguanosine mRNA capping (GO:0006370)2.70229898
135establishment of integrated proviral latency (GO:0075713)2.69612495
136mitochondrial DNA replication (GO:0006264)2.69123412
137regulation of centrosome cycle (GO:0046605)2.69056370
138formation of translation preinitiation complex (GO:0001731)2.68538642
139somatic hypermutation of immunoglobulin genes (GO:0016446)2.68385799
140somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68385799
141DNA replication-dependent nucleosome assembly (GO:0006335)2.68214516
142DNA replication-dependent nucleosome organization (GO:0034723)2.68214516
143ribosome assembly (GO:0042255)2.66826750
144membrane disassembly (GO:0030397)2.66312779
145nuclear envelope disassembly (GO:0051081)2.66312779
146aromatic amino acid family metabolic process (GO:0009072)2.64561030
147regulation of ubiquitin-protein transferase activity (GO:0051438)2.64230472
148response to X-ray (GO:0010165)2.64095042
149UDP-N-acetylglucosamine metabolic process (GO:0006047)2.63166293
150negative regulation of sterol transport (GO:0032372)2.62870634
151negative regulation of cholesterol transport (GO:0032375)2.62870634
152regulation of cholesterol homeostasis (GO:2000188)2.62507072
153negative regulation of fatty acid biosynthetic process (GO:0045717)2.60481453
154bile acid and bile salt transport (GO:0015721)2.58587509
155triglyceride homeostasis (GO:0070328)2.58464353
156acylglycerol homeostasis (GO:0055090)2.58464353
157ribosome biogenesis (GO:0042254)2.57014584
158sulfur amino acid metabolic process (GO:0000096)2.56750659
159nucleoside salvage (GO:0043174)2.55308676
1602-oxoglutarate metabolic process (GO:0006103)2.53812991
161tyrosine metabolic process (GO:0006570)2.51320756
162pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.50208183
163alpha-amino acid catabolic process (GO:1901606)2.50156339
164regulation of triglyceride catabolic process (GO:0010896)2.49782925
165IMP biosynthetic process (GO:0006188)2.49748040
166cellular glucuronidation (GO:0052695)2.48411791
167pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.47802183
168UMP metabolic process (GO:0046049)2.47802183
169pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.47802183
170UMP biosynthetic process (GO:0006222)2.47802183
171ethanol oxidation (GO:0006069)2.46597055
172IMP metabolic process (GO:0046040)2.46399114
173alpha-amino acid biosynthetic process (GO:1901607)2.45154798
174protein localization to kinetochore (GO:0034501)2.44526167
175DNA replication initiation (GO:0006270)2.42955256
176pantothenate metabolic process (GO:0015939)2.41764454
177protein-lipid complex remodeling (GO:0034368)2.40523224
178macromolecular complex remodeling (GO:0034367)2.40523224
179plasma lipoprotein particle remodeling (GO:0034369)2.40523224
180regulation of spindle organization (GO:0090224)2.40501682
181methionine metabolic process (GO:0006555)2.38830497
182plasma lipoprotein particle clearance (GO:0034381)2.38491334
183AMP metabolic process (GO:0046033)2.37622277
184plasma lipoprotein particle assembly (GO:0034377)2.37588775
185urate metabolic process (GO:0046415)2.35071351
186reverse cholesterol transport (GO:0043691)2.33247363
187maturation of SSU-rRNA (GO:0030490)2.32949253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.65594696
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.68139768
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.27959843
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22868416
5* RXR_22158963_ChIP-Seq_LIVER_Mouse3.16553378
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.89371291
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.71512193
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.46870009
9AR_21909140_ChIP-Seq_LNCAP_Human2.39911864
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.33654716
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29085838
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27206397
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.24575634
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.24419154
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.21829558
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19985872
17* GABP_17652178_ChIP-ChIP_JURKAT_Human2.16243321
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09891219
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97123446
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97001220
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.94486965
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90332202
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88734873
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88062384
25* VDR_23849224_ChIP-Seq_CD4+_Human1.87082605
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84740036
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.83910239
28* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83788628
29MYC_22102868_ChIP-Seq_BL_Human1.83643600
30* ETS1_20019798_ChIP-Seq_JURKAT_Human1.76867980
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75244629
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.72801961
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.70391506
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68571820
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68471696
36GATA1_22025678_ChIP-Seq_K562_Human1.67668596
37* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63113160
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58802562
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58587542
40XRN2_22483619_ChIP-Seq_HELA_Human1.55489841
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55140949
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54831841
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54522776
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.54071009
45DCP1A_22483619_ChIP-Seq_HELA_Human1.53844246
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52671879
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49028595
48FOXP3_21729870_ChIP-Seq_TREG_Human1.47023432
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46513238
50* GABP_19822575_ChIP-Seq_HepG2_Human1.46207402
51EWS_26573619_Chip-Seq_HEK293_Human1.43524499
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.42720610
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42419055
54* MYC_18940864_ChIP-ChIP_HL60_Human1.41768644
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41458972
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.40529054
57CLOCK_20551151_ChIP-Seq_293T_Human1.40397412
58ELK1_19687146_ChIP-ChIP_HELA_Human1.40073686
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39865509
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39803874
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38617209
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36453735
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.35709075
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34893103
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33995870
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31818310
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.30220494
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29362959
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29323206
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29264919
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28773850
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25679495
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25207076
74KDM5A_27292631_Chip-Seq_BREAST_Human1.24965752
75* ELK1_22589737_ChIP-Seq_MCF10A_Human1.24534281
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22547619
77* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22313902
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18471412
79BRD4_25478319_ChIP-Seq_HGPS_Human1.18062298
80ELF5_23300383_ChIP-Seq_T47D_Human1.16901763
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15527600
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14149447
83* TFEB_21752829_ChIP-Seq_HELA_Human1.14127905
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12979925
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11175067
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10621332
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09316310
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07781742
89MYB_26560356_Chip-Seq_TH1_Human1.07525198
90ZNF274_21170338_ChIP-Seq_K562_Hela1.06566678
91* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05977946
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05932037
93SPI1_23547873_ChIP-Seq_NB4_Human1.02494902
94TTF2_22483619_ChIP-Seq_HELA_Human1.01415842
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00147326
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00061071
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98269717
98* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98193718
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.97911899
100* SRF_21415370_ChIP-Seq_HL-1_Mouse0.97889276
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97107217
102MYB_26560356_Chip-Seq_TH2_Human0.96996337
103HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96919239
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.96507518
105VDR_21846776_ChIP-Seq_THP-1_Human0.96329538
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96132154
107FUS_26573619_Chip-Seq_HEK293_Human0.95415112
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95085560
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93990031
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93199639
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93104040
112* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92909443
113MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92727942
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92696650
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92696650
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91787341
117E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91746158
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91538631
119ATF3_27146783_Chip-Seq_COLON_Human0.91506780
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91499336
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90933555
122UTX_26944678_Chip-Seq_JUKART_Human0.89844527
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89550963
124GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89527449
125NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89014243
126NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88640885
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87988903
128MAF_26560356_Chip-Seq_TH1_Human0.87674163
129CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86340525
130STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85044717
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84910506
132ZNF263_19887448_ChIP-Seq_K562_Human0.84591613
133NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84358548
134YY1_21170310_ChIP-Seq_MESCs_Mouse0.83828891
135EZH2_27294783_Chip-Seq_NPCs_Mouse0.82738811
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82716420
137SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81621705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.62933731
2MP0002139_abnormal_hepatobiliary_system4.61890746
3MP0005365_abnormal_bile_salt4.07530619
4MP0003806_abnormal_nucleotide_metabolis3.67527727
5MP0005085_abnormal_gallbladder_physiolo3.54576252
6MP0003950_abnormal_plasma_membrane3.21579046
7MP0003786_premature_aging2.97274058
8MP0008875_abnormal_xenobiotic_pharmacok2.91161020
9MP0003693_abnormal_embryo_hatching2.52112659
10MP0003252_abnormal_bile_duct2.48313988
11MP0009840_abnormal_foam_cell2.37288400
12MP0008932_abnormal_embryonic_tissue2.11262098
13MP0010234_abnormal_vibrissa_follicle2.07991730
14MP0004957_abnormal_blastocyst_morpholog1.97674004
15MP0010329_abnormal_lipoprotein_level1.92340450
16MP0003221_abnormal_cardiomyocyte_apopto1.86412735
17MP0003705_abnormal_hypodermis_morpholog1.81474974
18MP0002396_abnormal_hematopoietic_system1.78979290
19MP0000609_abnormal_liver_physiology1.78508995
20MP0005083_abnormal_biliary_tract1.75294428
21MP0003656_abnormal_erythrocyte_physiolo1.74258805
22MP0002102_abnormal_ear_morphology1.66019213
23MP0010352_gastrointestinal_tract_polyps1.65831772
24MP0001666_abnormal_nutrient_absorption1.57337570
25MP0006035_abnormal_mitochondrial_morpho1.55012044
26MP0000358_abnormal_cell_content/1.54813888
27MP0010094_abnormal_chromosome_stability1.53268570
28MP0005332_abnormal_amino_acid1.50638428
29MP0003186_abnormal_redox_activity1.49542680
30MP0003111_abnormal_nucleus_morphology1.46817773
31MP0005379_endocrine/exocrine_gland_phen1.45305433
32MP0003077_abnormal_cell_cycle1.44950877
33MP0006072_abnormal_retinal_apoptosis1.44481471
34MP0002332_abnormal_exercise_endurance1.44437805
35MP0005319_abnormal_enzyme/_coenzyme1.43859070
36MP0000427_abnormal_hair_cycle1.43740458
37MP0003300_gastrointestinal_ulcer1.39125825
38MP0003868_abnormal_feces_composition1.36986305
39MP0001529_abnormal_vocalization1.35168983
40MP0003718_maternal_effect1.34190358
41MP0003763_abnormal_thymus_physiology1.33306580
42MP0002254_reproductive_system_inflammat1.32318567
43MP0006054_spinal_hemorrhage1.31548923
44MP0001697_abnormal_embryo_size1.28785790
45MP0001853_heart_inflammation1.28684651
46MP0002132_abnormal_respiratory_system1.28619915
47MP0000685_abnormal_immune_system1.28319755
48MP0000598_abnormal_liver_morphology1.27971861
49MP0003191_abnormal_cellular_cholesterol1.27520048
50MP0010307_abnormal_tumor_latency1.27336438
51MP0001727_abnormal_embryo_implantation1.26092790
52MP0003436_decreased_susceptibility_to1.24421565
53MP0008438_abnormal_cutaneous_collagen1.24151269
54MP0002163_abnormal_gland_morphology1.22477834
55MP0002138_abnormal_hepatobiliary_system1.21785684
56MP0001348_abnormal_lacrimal_gland1.20707440
57MP0002837_dystrophic_cardiac_calcinosis1.20638047
58MP0000013_abnormal_adipose_tissue1.19595257
59MP0002166_altered_tumor_susceptibility1.18529756
60MP0001672_abnormal_embryogenesis/_devel1.17481399
61MP0005380_embryogenesis_phenotype1.17481399
62MP0009333_abnormal_splenocyte_physiolog1.17306232
63MP0003890_abnormal_embryonic-extraembry1.17216200
64MP0000372_irregular_coat_pigmentation1.14865582
65MP0002160_abnormal_reproductive_system1.14053550
66MP0005023_abnormal_wound_healing1.13508267
67MP0009780_abnormal_chondrocyte_physiolo1.13094548
68MP0005220_abnormal_exocrine_pancreas1.12515729
69MP0008057_abnormal_DNA_replication1.09695635
70MP0002118_abnormal_lipid_homeostasis1.08457463
71MP0008007_abnormal_cellular_replicative1.07901610
72MP0003984_embryonic_growth_retardation1.07266623
73MP0001730_embryonic_growth_arrest1.06034300
74MP0005397_hematopoietic_system_phenotyp1.05914946
75MP0001545_abnormal_hematopoietic_system1.05914946
76MP0000569_abnormal_digit_pigmentation1.05183913
77MP0002088_abnormal_embryonic_growth/wei1.04566988
78MP0002877_abnormal_melanocyte_morpholog1.03035653
79MP0004808_abnormal_hematopoietic_stem1.02351484
80MP0000490_abnormal_crypts_of1.01678159
81MP0008469_abnormal_protein_level1.00286804
82MP0000689_abnormal_spleen_morphology0.99478373
83MP0009697_abnormal_copulation0.99338636
84MP0000350_abnormal_cell_proliferation0.98792423
85MP0005389_reproductive_system_phenotype0.98441009
86MP0009763_increased_sensitivity_to0.97969614
87MP0001191_abnormal_skin_condition0.97435253
88MP0001542_abnormal_bone_strength0.96857102
89MP0000313_abnormal_cell_death0.96380502
90MP0002019_abnormal_tumor_incidence0.96076954
91MP0001835_abnormal_antigen_presentation0.96048536
92MP0004215_abnormal_myocardial_fiber0.95934622
93MP0005464_abnormal_platelet_physiology0.95764339
94MP0008877_abnormal_DNA_methylation0.94960932
95MP0002398_abnormal_bone_marrow0.93937782
96MP0001800_abnormal_humoral_immune0.93910423
97MP0001764_abnormal_homeostasis0.93268835
98MP0005384_cellular_phenotype0.92253787
99MP0002722_abnormal_immune_system0.92106238
100MP0002086_abnormal_extraembryonic_tissu0.91619131
101MP0004185_abnormal_adipocyte_glucose0.90700499
102MP0006036_abnormal_mitochondrial_physio0.89339445
103MP0005408_hypopigmentation0.88748431
104MP0003195_calcinosis0.88523228
105MP0009643_abnormal_urine_homeostasis0.88185845
106MP0005451_abnormal_body_composition0.87099117
107MP0005076_abnormal_cell_differentiation0.87004903
108MP0003724_increased_susceptibility_to0.85854010
109MP0005621_abnormal_cell_physiology0.85431170
110MP0010368_abnormal_lymphatic_system0.84961684
111MP0002009_preneoplasia0.84566783
112MP0005670_abnormal_white_adipose0.84410791
113MP0005671_abnormal_response_to0.83978716
114MP0002405_respiratory_system_inflammati0.83585957
115MP0001243_abnormal_dermal_layer0.83214936
116MP0001919_abnormal_reproductive_system0.82752503
117MP0002084_abnormal_developmental_patter0.82576758
118MP0002933_joint_inflammation0.82443416
119MP0000465_gastrointestinal_hemorrhage0.82380883
120MP0005584_abnormal_enzyme/coenzyme_acti0.82026868
121MP0001845_abnormal_inflammatory_respons0.81559418
122MP0004233_abnormal_muscle_weight0.81142556
123MP0006082_CNS_inflammation0.80957534
124MP0001661_extended_life_span0.80898317
125MP0009384_cardiac_valve_regurgitation0.80481240
126MP0008058_abnormal_DNA_repair0.80441393
127MP0004019_abnormal_vitamin_homeostasis0.80348464
128MP0005666_abnormal_adipose_tissue0.80238507
129MP0005257_abnormal_intraocular_pressure0.80176645
130MP0004197_abnormal_fetal_growth/weight/0.79947572
131MP0004272_abnormal_basement_membrane0.79340061
132MP0001873_stomach_inflammation0.78461659
133MP0005266_abnormal_metabolism0.78360435
134MP0000371_diluted_coat_color0.78315966
135MP0001216_abnormal_epidermal_layer0.77903803
136MP0010155_abnormal_intestine_physiology0.77560668
137MP0002006_tumorigenesis0.77483871
138MP0002429_abnormal_blood_cell0.76663240
139MP0002060_abnormal_skin_morphology0.76323105
140MP0002452_abnormal_antigen_presenting0.76203236
141MP0000716_abnormal_immune_system0.75753248
142MP0001188_hyperpigmentation0.74617294
143MP0004947_skin_inflammation0.74549345
144MP0002723_abnormal_immune_serum0.73837838
145MP0003943_abnormal_hepatobiliary_system0.73662625
146MP0009764_decreased_sensitivity_to0.73511514
147MP0005395_other_phenotype0.72089083
148MP0000703_abnormal_thymus_morphology0.71817625
149MP0001533_abnormal_skeleton_physiology0.71731946
150MP0001881_abnormal_mammary_gland0.71586707
151MP0004134_abnormal_chest_morphology0.70832074
152MP0002080_prenatal_lethality0.70272665
153MP0010678_abnormal_skin_adnexa0.70232564
154MP0001929_abnormal_gametogenesis0.70158309
155MP0000647_abnormal_sebaceous_gland0.69972483
156MP0001119_abnormal_female_reproductive0.69792596
157MP0003937_abnormal_limbs/digits/tail_de0.68907451
158MP0002210_abnormal_sex_determination0.67565449
159MP0005165_increased_susceptibility_to0.66089920
160MP0004782_abnormal_surfactant_physiolog0.65937017
161MP0005084_abnormal_gallbladder_morpholo0.65436850
162MP0000015_abnormal_ear_pigmentation0.63572579
163MP0002177_abnormal_outer_ear0.63084003
164MP0000627_abnormal_mammary_gland0.62441875

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.76335656
2Hypobetalipoproteinemia (HP:0003563)4.71574178
3Intrahepatic cholestasis (HP:0001406)4.67469823
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.62933604
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.62253940
6Xanthomatosis (HP:0000991)4.19328232
7Prolonged partial thromboplastin time (HP:0003645)3.65827413
8Hypolipoproteinemia (HP:0010981)3.53092509
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.38649336
10Abnormality of the intrinsic pathway (HP:0010989)3.33461571
11Cutaneous melanoma (HP:0012056)3.33052558
12Chromsome breakage (HP:0040012)3.24192697
13Abnormality of chromosome stability (HP:0003220)3.23070006
14Abnormal protein glycosylation (HP:0012346)3.22747904
15Abnormal glycosylation (HP:0012345)3.22747904
16Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.22747904
17Abnormal protein N-linked glycosylation (HP:0012347)3.22747904
18Abnormality of the common coagulation pathway (HP:0010990)3.19111743
19Hyperammonemia (HP:0001987)3.17425868
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.14348203
21Abnormality of the preputium (HP:0100587)3.07848823
22Hypoglycemic coma (HP:0001325)3.04074795
23Hyperlipoproteinemia (HP:0010980)3.01763535
24Abnormality of methionine metabolism (HP:0010901)2.94047435
25Hypoalphalipoproteinemia (HP:0003233)2.93836988
26Tongue fasciculations (HP:0001308)2.90214643
27Microvesicular hepatic steatosis (HP:0001414)2.90038864
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.89676269
29Abnormality of sulfur amino acid metabolism (HP:0004339)2.87082777
30Myocardial infarction (HP:0001658)2.83561724
31Abnormality of pyrimidine metabolism (HP:0004353)2.82878030
32Fat malabsorption (HP:0002630)2.82807698
33Progressive inability to walk (HP:0002505)2.77261670
34Type I transferrin isoform profile (HP:0003642)2.75233844
35Complement deficiency (HP:0004431)2.72812968
36Increased serum lactate (HP:0002151)2.72812956
37Abnormality of the anterior horn cell (HP:0006802)2.71771140
38Degeneration of anterior horn cells (HP:0002398)2.71771140
39Meckel diverticulum (HP:0002245)2.70572744
40Abnormal cartilage morphology (HP:0002763)2.65900464
41Progressive external ophthalmoplegia (HP:0000590)2.64260383
42Sensory axonal neuropathy (HP:0003390)2.61848701
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60128784
44Hepatocellular carcinoma (HP:0001402)2.59253884
45Acanthocytosis (HP:0001927)2.58309621
46Increased hepatocellular lipid droplets (HP:0006565)2.58274579
47Hyperglycinemia (HP:0002154)2.56147582
48Abnormality of the ileum (HP:0001549)2.55292901
49Hyperglycinuria (HP:0003108)2.54375277
50Ketosis (HP:0001946)2.52817326
51Entropion (HP:0000621)2.52750924
52Hyperbilirubinemia (HP:0002904)2.51161437
53Epidermoid cyst (HP:0200040)2.48802917
54Progressive muscle weakness (HP:0003323)2.48434141
55Abnormality of glycine metabolism (HP:0010895)2.47683812
56Abnormality of serine family amino acid metabolism (HP:0010894)2.47683812
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.46689197
58Increased CSF lactate (HP:0002490)2.45279359
59Birth length less than 3rd percentile (HP:0003561)2.44345423
60Abnormality of glutamine family amino acid metabolism (HP:0010902)2.43293478
61Joint hemorrhage (HP:0005261)2.42722515
62Abnormality of serum amino acid levels (HP:0003112)2.42701024
63Abnormality of the pons (HP:0007361)2.39373260
64Lipid accumulation in hepatocytes (HP:0006561)2.33263154
65Multiple enchondromatosis (HP:0005701)2.32514800
66Duodenal stenosis (HP:0100867)2.31946687
67Small intestinal stenosis (HP:0012848)2.31946687
68Thrombocytosis (HP:0001894)2.31734269
69Upper limb muscle weakness (HP:0003484)2.30770772
70Abnormality of nucleobase metabolism (HP:0010932)2.30177577
71Hypokinesia (HP:0002375)2.27684254
72Spastic diplegia (HP:0001264)2.24821952
73Conjugated hyperbilirubinemia (HP:0002908)2.23994032
74Oral leukoplakia (HP:0002745)2.22889952
75Acute encephalopathy (HP:0006846)2.21916449
76Acute necrotizing encephalopathy (HP:0006965)2.20633368
77Muscle fibrillation (HP:0010546)2.20032252
78Rough bone trabeculation (HP:0100670)2.19995564
79Myelodysplasia (HP:0002863)2.19256890
80Renal cortical cysts (HP:0000803)2.19148099
81Abnormality of fatty-acid metabolism (HP:0004359)2.17751764
82Progressive macrocephaly (HP:0004481)2.16637284
83Hypercholesterolemia (HP:0003124)2.16024102
843-Methylglutaconic aciduria (HP:0003535)2.14313977
85Abnormality of complement system (HP:0005339)2.11786987
86Rhabdomyosarcoma (HP:0002859)2.11028067
87Protrusio acetabuli (HP:0003179)2.10023447
88Posterior subcapsular cataract (HP:0007787)2.08636286
89Spontaneous abortion (HP:0005268)2.07647023
90Poikiloderma (HP:0001029)2.07604957
91Abnormality of the umbilical cord (HP:0010881)2.06064279
92Breast carcinoma (HP:0003002)2.04931907
93Abnormality of purine metabolism (HP:0004352)2.03827350
94Clubbing of toes (HP:0100760)2.03468832
95Beaking of vertebral bodies (HP:0004568)2.02838252
96Lactic acidosis (HP:0003128)2.02048096
97Abnormality of iron homeostasis (HP:0011031)2.01497346
98Abnormal mitochondria in muscle tissue (HP:0008316)1.99994696
99Poikilocytosis (HP:0004447)1.99730171
100Ureteral duplication (HP:0000073)1.99437638
101Steatorrhea (HP:0002570)1.99336827
102Increased mean platelet volume (HP:0011877)1.98661972
103Abnormality of glycolysis (HP:0004366)1.98496867
104Metaphyseal dysplasia (HP:0100255)1.98110198
105Abnormality of the duodenum (HP:0002246)1.97365867
106Shoulder girdle muscle weakness (HP:0003547)1.97282899
107Abnormality of transition element cation homeostasis (HP:0011030)1.96377275
108Hypoplasia of the pons (HP:0012110)1.95528671
109Abnormal foot bone ossification (HP:0010675)1.95499216
110Thrombophlebitis (HP:0004418)1.94712904
111Sloping forehead (HP:0000340)1.94041705
112Ependymoma (HP:0002888)1.93323984
113Aplastic anemia (HP:0001915)1.93214655
114Pancytopenia (HP:0001876)1.92282521
115Hypothermia (HP:0002045)1.92128817
116Abnormality of T cell physiology (HP:0011840)1.91778565
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90946118
118Abnormal platelet volume (HP:0011876)1.90185125
119Gingival bleeding (HP:0000225)1.89800559
120Glioma (HP:0009733)1.89238406
121Hypergonadotropic hypogonadism (HP:0000815)1.89141223
122Breast hypoplasia (HP:0003187)1.88824763
123Methylmalonic acidemia (HP:0002912)1.88430547
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88350622
125Postnatal microcephaly (HP:0005484)1.87542445
126Skin nodule (HP:0200036)1.87448372
127Neoplasm of the peripheral nervous system (HP:0100007)1.87251645
128Abnormality of the heme biosynthetic pathway (HP:0010472)1.85743623
129Sparse eyelashes (HP:0000653)1.85148767
130Hyperglycemia (HP:0003074)1.85064288
131Prominent metopic ridge (HP:0005487)1.84698654
132Abnormality of the hip-girdle musculature (HP:0001445)1.83928797
133Abnormality of the musculature of the pelvis (HP:0001469)1.83928797
134Adrenal hypoplasia (HP:0000835)1.83810645
135Abnormal umbilical cord blood vessels (HP:0011403)1.82885379
136Single umbilical artery (HP:0001195)1.82885379
137Abnormality of the fetal cardiovascular system (HP:0010948)1.82885379
138Cupped ribs (HP:0000887)1.81753133
139Abnormality of the carotid arteries (HP:0005344)1.81222906
140Deep philtrum (HP:0002002)1.80775509
141Carpal bone hypoplasia (HP:0001498)1.80620786
142Insidious onset (HP:0003587)1.80428406
143Termporal pattern (HP:0011008)1.80428406
144Orthostatic hypotension (HP:0001278)1.79432788
145Tetraparesis (HP:0002273)1.78997698
146Delayed CNS myelination (HP:0002188)1.78884981
147Secondary amenorrhea (HP:0000869)1.78751968
148Cerebral edema (HP:0002181)1.78433298
149Abnormality of the Achilles tendon (HP:0005109)1.77616883
150Mitochondrial inheritance (HP:0001427)1.76347191
151Increased serum pyruvate (HP:0003542)1.75104024
152Pelvic girdle muscle weakness (HP:0003749)1.74478488
153Arteriovenous malformation (HP:0100026)1.74293028
154Ketoacidosis (HP:0001993)1.73567992
155IgG deficiency (HP:0004315)1.73457959
156Brittle hair (HP:0002299)1.73455442
157Abnormality of T cell number (HP:0011839)1.72669253
158Abnormality of the astrocytes (HP:0100707)1.72616012
159Astrocytoma (HP:0009592)1.72616012
160Abnormality of alanine metabolism (HP:0010916)1.72580342
161Hyperalaninemia (HP:0003348)1.72580342
162Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72580342
163Pancreatitis (HP:0001733)1.72323801
164Delayed gross motor development (HP:0002194)1.72278944
165Abnormal tarsal ossification (HP:0008369)1.72205573
166Irregular epiphyses (HP:0010582)1.72014026
167Osteolytic defects of the hand bones (HP:0009699)1.71827647
168Osteolytic defects of the phalanges of the hand (HP:0009771)1.71827647
169Melanoma (HP:0002861)1.71779448
170Peritonitis (HP:0002586)1.71597735
171T lymphocytopenia (HP:0005403)1.71524476
172Abnormality of T cells (HP:0002843)1.71055213
173IgM deficiency (HP:0002850)1.70670328
174Reticulocytosis (HP:0001923)1.70586458
175Increased serum ferritin (HP:0003281)1.67506030
176Megaloblastic anemia (HP:0001889)1.66844106
177Epistaxis (HP:0000421)1.65795671
178Abnormality of dicarboxylic acid metabolism (HP:0010995)1.65751343
179Dicarboxylic aciduria (HP:0003215)1.65751343
180Reduced antithrombin III activity (HP:0001976)1.64369036
181Squamous cell carcinoma (HP:0002860)1.64183268
182Microretrognathia (HP:0000308)1.63215535
183Abnormality of subcutaneous fat tissue (HP:0001001)1.62704976
184Reduced subcutaneous adipose tissue (HP:0003758)1.62117578
185Esophageal varix (HP:0002040)1.61690638
186Hypertriglyceridemia (HP:0002155)1.60586843
187Cervical subluxation (HP:0003308)1.60194912
188Lethargy (HP:0001254)1.59613581
189Pustule (HP:0200039)1.58202787

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.65989069
2MST43.52429356
3TSSK63.19725573
4SCYL22.65167059
5EIF2AK12.63411800
6FLT32.44026379
7PKN22.40638662
8BCKDK2.39816578
9WEE12.39507622
10BRSK22.29975774
11TESK22.27470260
12CDC72.26677857
13SIK32.22578557
14ERBB32.13689877
15TRIB32.07830756
16MAP4K12.04754712
17STK102.04268202
18BCR2.01623461
19ACVR1B1.98712972
20TAOK31.97449945
21NME21.95909110
22MAP2K31.92489601
23BUB11.89609956
24IRAK31.84454230
25RPS6KA41.79408971
26MAP3K121.70582266
27LATS11.70437529
28EIF2AK31.68777247
29ERN11.67710282
30FRK1.67081990
31EIF2AK21.61159177
32ZAP701.56158209
33MKNK21.56076214
34BMPR21.55491723
35MAP3K31.51412986
36EEF2K1.50031409
37KDR1.47012228
38JAK31.46713936
39ZAK1.46684514
40NEK21.44539748
41PBK1.40911166
42MAP4K21.37664037
43SIK11.35418944
44STK31.32968648
45LRRK21.32342287
46MAP3K41.29172608
47TYK21.27543077
48MAP3K101.22306686
49BMPR1B1.20129904
50PDK21.19275131
51MAP2K71.17711935
52FGFR41.16348907
53ERBB41.15097156
54PLK21.13566723
55PIM21.13058568
56LIMK11.11745108
57MAP3K81.09578452
58STK391.09563247
59GRK11.09498593
60MAP3K141.09240996
61RPS6KB21.08864731
62CLK11.07059963
63TGFBR11.06860802
64CDK41.06609795
65TAF11.05910001
66TEC1.05239794
67VRK11.03312085
68NEK91.01611518
69STK38L0.99973019
70AURKB0.98632724
71PLK10.98115497
72MST1R0.97392071
73VRK20.93963773
74MAP3K110.92606795
75PASK0.92257458
76PRKCI0.91068263
77PIM10.90883948
78CSNK1A1L0.89444856
79TTK0.89301445
80MAP3K60.88924536
81NEK10.87647710
82CDK70.85949690
83CSF1R0.85861886
84PLK40.85055120
85STK240.84709446
86CSNK1G30.82634551
87STK160.81958463
88SRPK10.81421324
89RAF10.81083563
90ARAF0.80171724
91GRK60.79504438
92TAOK10.79323225
93AKT30.79183193
94RIPK10.78221670
95CDK60.77061651
96CDK120.76587381
97CSNK1G10.74919337
98PAK40.71063708
99ITK0.70627320
100MELK0.69744466
101BRAF0.68544897
102TBK10.68046070
103IKBKB0.65160055
104ABL20.64914531
105TXK0.64834639
106PAK20.64026703
107MAPK110.63794548
108PLK30.63069621
109MAP3K50.62528434
110JAK20.59879915
111TTN0.59783889
112DYRK30.59335712
113KIT0.57906846
114RPS6KA50.57421698
115KSR10.55936784
116NUAK10.53677819
117CHEK20.53634913
118ALK0.53234388
119MARK30.52797212
120CHEK10.52025157
121BRSK10.51675319
122CDK80.51064399
123PIK3CG0.49078411
124PDGFRA0.48679161
125ATR0.48605735
126CSNK1G20.48219813
127MKNK10.46901901
128MAPKAPK30.46887127
129PRKG20.46504153
130MOS0.45748947
131TLK10.44944219
132LCK0.44085538
133TIE10.43742028
134TGFBR20.43346020
135DDR20.42648939
136STK40.42406686
137BTK0.41366198
138AURKA0.41209146
139MUSK0.40188045
140ATM0.39354503
141CCNB10.38367361
142WNK40.38003361
143TRPM70.36526113
144BRD40.35243844
145MET0.33747096
146CHUK0.33324055
147CAMKK20.30020611
148MAPKAPK50.28673502

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.98884847
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.56462208
3One carbon pool by folate_Homo sapiens_hsa006702.49320736
4Nitrogen metabolism_Homo sapiens_hsa009102.47378822
5Selenocompound metabolism_Homo sapiens_hsa004502.23056565
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.08936267
7Folate biosynthesis_Homo sapiens_hsa007902.04560393
8Arginine biosynthesis_Homo sapiens_hsa002202.02608838
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01481034
10Caffeine metabolism_Homo sapiens_hsa002322.01080052
11DNA replication_Homo sapiens_hsa030302.00548922
12Drug metabolism - other enzymes_Homo sapiens_hsa009831.98112524
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92389827
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90356097
15Complement and coagulation cascades_Homo sapiens_hsa046101.82965211
16Fatty acid degradation_Homo sapiens_hsa000711.79271651
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78591734
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75385667
19Tryptophan metabolism_Homo sapiens_hsa003801.63030360
20Sulfur relay system_Homo sapiens_hsa041221.62089914
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.60838791
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58689233
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52531688
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49524851
25Vitamin B6 metabolism_Homo sapiens_hsa007501.48025514
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46056433
27Biosynthesis of amino acids_Homo sapiens_hsa012301.45011099
28Mismatch repair_Homo sapiens_hsa034301.41112436
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39984846
30Peroxisome_Homo sapiens_hsa041461.37014636
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35995677
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35214745
33RNA transport_Homo sapiens_hsa030131.34842865
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29753231
35Pentose phosphate pathway_Homo sapiens_hsa000301.28414798
36Propanoate metabolism_Homo sapiens_hsa006401.26884186
37PPAR signaling pathway_Homo sapiens_hsa033201.22887333
38mRNA surveillance pathway_Homo sapiens_hsa030151.22180391
39Fatty acid metabolism_Homo sapiens_hsa012121.21951813
40Nucleotide excision repair_Homo sapiens_hsa034201.21386169
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19793295
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19326804
43Carbon metabolism_Homo sapiens_hsa012001.16544593
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15482484
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.14965935
46Chemical carcinogenesis_Homo sapiens_hsa052041.14610917
47Ribosome_Homo sapiens_hsa030101.13474145
48Pyrimidine metabolism_Homo sapiens_hsa002401.10990673
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09767788
50Proteasome_Homo sapiens_hsa030501.07979811
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07839207
52beta-Alanine metabolism_Homo sapiens_hsa004101.05962675
53Shigellosis_Homo sapiens_hsa051311.05141682
54Starch and sucrose metabolism_Homo sapiens_hsa005001.01698658
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01238466
56Oocyte meiosis_Homo sapiens_hsa041140.99526216
57Cell cycle_Homo sapiens_hsa041100.99410218
58Staphylococcus aureus infection_Homo sapiens_hsa051500.98556163
59RNA polymerase_Homo sapiens_hsa030200.95598816
60Histidine metabolism_Homo sapiens_hsa003400.93460168
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.93436287
62Pyruvate metabolism_Homo sapiens_hsa006200.92674832
63Base excision repair_Homo sapiens_hsa034100.92422372
64Butanoate metabolism_Homo sapiens_hsa006500.92283109
65Retinol metabolism_Homo sapiens_hsa008300.89261814
66Sulfur metabolism_Homo sapiens_hsa009200.89213285
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.86875224
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86068189
69Non-homologous end-joining_Homo sapiens_hsa034500.86043246
70Systemic lupus erythematosus_Homo sapiens_hsa053220.85757525
71Epstein-Barr virus infection_Homo sapiens_hsa051690.83661404
72p53 signaling pathway_Homo sapiens_hsa041150.83184259
73Spliceosome_Homo sapiens_hsa030400.80858500
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80470161
75Homologous recombination_Homo sapiens_hsa034400.79134918
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78825018
77RNA degradation_Homo sapiens_hsa030180.76071341
78Vibrio cholerae infection_Homo sapiens_hsa051100.74353181
79Antigen processing and presentation_Homo sapiens_hsa046120.73831181
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72427849
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70610913
82Phenylalanine metabolism_Homo sapiens_hsa003600.69809572
83Protein export_Homo sapiens_hsa030600.69149225
84Arginine and proline metabolism_Homo sapiens_hsa003300.68450959
85Lysine degradation_Homo sapiens_hsa003100.68225825
86TGF-beta signaling pathway_Homo sapiens_hsa043500.68014451
87Fat digestion and absorption_Homo sapiens_hsa049750.67226182
88Oxidative phosphorylation_Homo sapiens_hsa001900.64479145
89Tyrosine metabolism_Homo sapiens_hsa003500.63709379
90Sphingolipid metabolism_Homo sapiens_hsa006000.63455300
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63311712
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63259417
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62997135
94Glutathione metabolism_Homo sapiens_hsa004800.61183541
95Hepatitis B_Homo sapiens_hsa051610.60776291
96Basal transcription factors_Homo sapiens_hsa030220.59317002
97Vitamin digestion and absorption_Homo sapiens_hsa049770.58929991
98Primary immunodeficiency_Homo sapiens_hsa053400.57974630
99Bile secretion_Homo sapiens_hsa049760.57004400
100Fatty acid elongation_Homo sapiens_hsa000620.56022609
101Regulation of autophagy_Homo sapiens_hsa041400.55285522
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55075958
103Legionellosis_Homo sapiens_hsa051340.51831524
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51063108
105Alcoholism_Homo sapiens_hsa050340.51010417
106ABC transporters_Homo sapiens_hsa020100.50796650
107Circadian rhythm_Homo sapiens_hsa047100.49324519
108Viral carcinogenesis_Homo sapiens_hsa052030.49211126
109Apoptosis_Homo sapiens_hsa042100.48595729
110Herpes simplex infection_Homo sapiens_hsa051680.47468820
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.40864961
112Metabolic pathways_Homo sapiens_hsa011000.39762389
113Collecting duct acid secretion_Homo sapiens_hsa049660.39069821
114TNF signaling pathway_Homo sapiens_hsa046680.37894296
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37890578
116Melanoma_Homo sapiens_hsa052180.36792661
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36769767
118Rheumatoid arthritis_Homo sapiens_hsa053230.34449437
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34420964
120Fanconi anemia pathway_Homo sapiens_hsa034600.34214365
121Glycerolipid metabolism_Homo sapiens_hsa005610.33779925
122Galactose metabolism_Homo sapiens_hsa000520.33768457
123Parkinsons disease_Homo sapiens_hsa050120.33260889
124HTLV-I infection_Homo sapiens_hsa051660.32983686
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32579570
126Insulin resistance_Homo sapiens_hsa049310.30675796
127Thyroid cancer_Homo sapiens_hsa052160.30110826
128Purine metabolism_Homo sapiens_hsa002300.29817222
129Measles_Homo sapiens_hsa051620.29491657
130Small cell lung cancer_Homo sapiens_hsa052220.29303578
131Steroid biosynthesis_Homo sapiens_hsa001000.28428052
132N-Glycan biosynthesis_Homo sapiens_hsa005100.28386112
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.27351203
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21421499
135Phototransduction_Homo sapiens_hsa047440.20931807
136Hippo signaling pathway_Homo sapiens_hsa043900.19843438
137Type I diabetes mellitus_Homo sapiens_hsa049400.18181762
138Huntingtons disease_Homo sapiens_hsa050160.17805261
139Hematopoietic cell lineage_Homo sapiens_hsa046400.17799898
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15140346
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.13903568
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13849443
143Influenza A_Homo sapiens_hsa051640.13235725
144Colorectal cancer_Homo sapiens_hsa052100.12858426

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