SLC25A34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC25A34 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)8.25745293
2cardiac myofibril assembly (GO:0055003)7.59164499
3positive regulation of glycolytic process (GO:0045821)7.38777236
4myofibril assembly (GO:0030239)6.75020838
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.72703146
6tricarboxylic acid cycle (GO:0006099)6.62153501
7negative regulation of potassium ion transmembrane transport (GO:1901380)6.20502745
8regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.13276793
9cardiac muscle contraction (GO:0060048)6.03246864
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.00609382
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.79479774
12regulation of glucokinase activity (GO:0033131)5.78002248
13regulation of hexokinase activity (GO:1903299)5.78002248
14regulation of actin filament-based movement (GO:1903115)5.63767335
15cardiac muscle cell development (GO:0055013)5.57541698
16carnitine shuttle (GO:0006853)5.56270772
17muscle filament sliding (GO:0030049)5.54679179
18actin-myosin filament sliding (GO:0033275)5.54679179
19regulation of relaxation of muscle (GO:1901077)5.50993574
20bundle of His cell to Purkinje myocyte communication (GO:0086069)5.44030883
21regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.41825495
22plasma membrane repair (GO:0001778)5.39435646
23regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.30519557
24adult heart development (GO:0007512)5.29457285
25cardiac cell development (GO:0055006)5.23341264
26ventricular cardiac muscle cell action potential (GO:0086005)5.22971485
27lactate metabolic process (GO:0006089)5.11526144
28actomyosin structure organization (GO:0031032)5.03718404
29negative regulation of gluconeogenesis (GO:0045721)5.02241808
30fatty acid transmembrane transport (GO:1902001)4.97870003
31regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.97408269
32regulation of type B pancreatic cell apoptotic process (GO:2000674)4.96200768
33ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.95154163
34cardiac muscle hypertrophy (GO:0003300)4.94248945
35cardiac muscle tissue morphogenesis (GO:0055008)4.92868106
36regulation of skeletal muscle contraction (GO:0014819)4.89493404
37positive regulation of respiratory burst (GO:0060267)4.82322427
38regulation of acyl-CoA biosynthetic process (GO:0050812)4.81267550
392-oxoglutarate metabolic process (GO:0006103)4.75638191
40endocrine pancreas development (GO:0031018)4.75340549
41negative regulation of protein oligomerization (GO:0032460)4.71318007
42fatty acid homeostasis (GO:0055089)4.68165478
43striated muscle hypertrophy (GO:0014897)4.67676329
44heart trabecula formation (GO:0060347)4.64925428
45regulation of sarcomere organization (GO:0060297)4.64330577
46actin-mediated cell contraction (GO:0070252)4.57899776
47striated muscle contraction (GO:0006941)4.56579392
48regulation of sequestering of triglyceride (GO:0010889)4.48545273
49regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.48204855
50cell communication involved in cardiac conduction (GO:0086065)4.47404187
51NADH metabolic process (GO:0006734)4.46674960
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.45315318
53regulation of striated muscle contraction (GO:0006942)4.41862688
54muscle tissue morphogenesis (GO:0060415)4.38089108
55negative regulation of acute inflammatory response (GO:0002674)4.37507235
56regulation of coenzyme metabolic process (GO:0051196)4.36482250
57regulation of cofactor metabolic process (GO:0051193)4.36482250
58fatty acid beta-oxidation (GO:0006635)4.34128042
59regulation of the force of heart contraction (GO:0002026)4.32754798
60regulation of cell communication by electrical coupling (GO:0010649)4.32203058
61carnitine transmembrane transport (GO:1902603)4.31663166
62regulation of energy homeostasis (GO:2000505)4.31452915
63lysine catabolic process (GO:0006554)4.28253213
64lysine metabolic process (GO:0006553)4.28253213
65sarcoplasmic reticulum calcium ion transport (GO:0070296)4.24128716
66aspartate family amino acid catabolic process (GO:0009068)4.19899402
67nitric oxide mediated signal transduction (GO:0007263)4.17903212
68muscle hypertrophy (GO:0014896)4.15169863
69heart process (GO:0003015)4.13918432
70heart contraction (GO:0060047)4.13918432
71regulation of membrane repolarization (GO:0060306)4.12237078
72regulation of cardiac muscle cell contraction (GO:0086004)4.11852542
73amino-acid betaine transport (GO:0015838)4.10466161
74carnitine transport (GO:0015879)4.10466161
75positive regulation of glycogen biosynthetic process (GO:0045725)4.09555037
76regulation of glycolytic process (GO:0006110)3.98825825
77regulation of fatty acid oxidation (GO:0046320)3.95826201
78creatine metabolic process (GO:0006600)3.95425654
79cell communication by electrical coupling (GO:0010644)3.94986405
80mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.94870641
81response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.91295385
82mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.85591621
83regulation of cardiac muscle contraction (GO:0055117)3.84013905
84kidney morphogenesis (GO:0060993)3.80720770
85respiratory electron transport chain (GO:0022904)3.78657668
86positive regulation of peptide hormone secretion (GO:0090277)3.70902016
87relaxation of cardiac muscle (GO:0055119)3.68276217
88ketone body metabolic process (GO:1902224)3.67992917
89electron transport chain (GO:0022900)3.66877844
90energy coupled proton transport, down electrochemical gradient (GO:0015985)3.66810388
91ATP synthesis coupled proton transport (GO:0015986)3.66810388
92negative regulation of cytosolic calcium ion concentration (GO:0051481)3.65706492
93fatty acid catabolic process (GO:0009062)3.64893145
94oxygen transport (GO:0015671)3.64459117
95cardiac muscle cell action potential involved in contraction (GO:0086002)3.64306210
96positive regulation of glycogen metabolic process (GO:0070875)3.62094150
97cardiac muscle adaptation (GO:0014887)3.61966944
98cardiac muscle hypertrophy in response to stress (GO:0014898)3.61966944
99muscle hypertrophy in response to stress (GO:0003299)3.61966944
100regulation of heart rate (GO:0002027)3.61937878
101positive regulation of insulin secretion (GO:0032024)3.61426518
102regulation of sulfur metabolic process (GO:0042762)3.60136740
103cardiac muscle cell action potential (GO:0086001)3.60103490
104positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.59070498
105fatty acid oxidation (GO:0019395)3.55840623
106positive regulation of peptide secretion (GO:0002793)3.55832625
107inositol phosphate catabolic process (GO:0071545)3.55487310
108chemosensory behavior (GO:0007635)3.54997387
109water-soluble vitamin biosynthetic process (GO:0042364)3.54491149
110oxidative phosphorylation (GO:0006119)3.53721327
111tricarboxylic acid metabolic process (GO:0072350)3.52446661
112lipid oxidation (GO:0034440)3.50262528
113regulation of ATPase activity (GO:0043462)3.50025679
114regulation of ATP catabolic process (GO:1903289)3.50025679
115succinate metabolic process (GO:0006105)3.49186846
116actin filament-based movement (GO:0030048)3.47352992
117dendritic spine morphogenesis (GO:0060997)3.46056940
118oxaloacetate metabolic process (GO:0006107)3.45621649
119positive regulation of heart rate (GO:0010460)3.44229813
120insulin secretion (GO:0030073)3.39652795
121regulation of heart contraction (GO:0008016)3.39378698
122negative regulation of potassium ion transport (GO:0043267)3.38385320
123acetyl-CoA metabolic process (GO:0006084)3.34784171
124short-chain fatty acid metabolic process (GO:0046459)3.33666163
125phasic smooth muscle contraction (GO:0014821)3.33422395
126positive regulation of heart contraction (GO:0045823)3.32656267
127cellular ketone body metabolic process (GO:0046950)3.29706824
128branched-chain amino acid catabolic process (GO:0009083)3.29146225
129regulation of cellular carbohydrate catabolic process (GO:0043471)3.28186376
130regulation of carbohydrate catabolic process (GO:0043470)3.28186376
131behavioral response to nicotine (GO:0035095)3.21519612
132inositol phosphate dephosphorylation (GO:0046855)3.19180773
133phosphorylated carbohydrate dephosphorylation (GO:0046838)3.19180773
134respiratory chain complex IV assembly (GO:0008535)3.09149586
135negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.07160584
136negative regulation of hormone biosynthetic process (GO:0032353)3.03105078
137regulation of feeding behavior (GO:0060259)2.97121977
138L-fucose catabolic process (GO:0042355)2.96658353
139fucose catabolic process (GO:0019317)2.96658353
140L-fucose metabolic process (GO:0042354)2.96658353
141adaptation of signaling pathway (GO:0023058)2.90391075
142calcium ion import (GO:0070509)2.90135772
143glandular epithelial cell differentiation (GO:0002067)2.87875610
144regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.87848871
145polyol catabolic process (GO:0046174)2.87101564
146positive regulation of protein autophosphorylation (GO:0031954)2.86606321
147positive regulation of hormone secretion (GO:0046887)2.86168582
148positive regulation of growth hormone secretion (GO:0060124)2.84392256
149positive regulation of cellular carbohydrate metabolic process (GO:0010676)2.80580571
150response to pheromone (GO:0019236)2.79853038
151dentate gyrus development (GO:0021542)2.78125264
152prostate gland growth (GO:0060736)2.76024484
153signal peptide processing (GO:0006465)2.74898017
154regulation of insulin secretion (GO:0050796)2.70591017
155keratinocyte development (GO:0003334)2.67443177
156negative regulation of glycogen metabolic process (GO:0070874)2.67417983
157adult feeding behavior (GO:0008343)2.66150491
158detection of calcium ion (GO:0005513)2.64307155
159positive regulation of vasodilation (GO:0045909)2.63524040
160brain morphogenesis (GO:0048854)2.62582819
161kynurenine metabolic process (GO:0070189)2.62099843
162peristalsis (GO:0030432)2.61292301
163positive regulation of carbohydrate metabolic process (GO:0045913)2.58081327
164type B pancreatic cell development (GO:0003323)2.57101132
165negative regulation of hormone metabolic process (GO:0032351)2.56934691
166cytochrome complex assembly (GO:0017004)2.56237113
167indole-containing compound catabolic process (GO:0042436)2.55888920
168indolalkylamine catabolic process (GO:0046218)2.55888920
169tryptophan catabolic process (GO:0006569)2.55888920
170positive regulation of meiosis (GO:0045836)2.55351417
171regulation of peptide hormone secretion (GO:0090276)2.54649993
172peptide hormone secretion (GO:0030072)2.54062756
173peptide hormone processing (GO:0016486)2.53031364
174startle response (GO:0001964)2.51817877
175regulation of peptide secretion (GO:0002791)2.48915612
176establishment of protein localization to Golgi (GO:0072600)2.48876989
177fructose metabolic process (GO:0006000)2.46657461
178positive regulation of glucose metabolic process (GO:0010907)2.46439770
179protein targeting to Golgi (GO:0000042)2.46425556
180peptide secretion (GO:0002790)2.46003396
181response to gravity (GO:0009629)2.45093231
182xenobiotic catabolic process (GO:0042178)2.45006124
183detection of light stimulus involved in visual perception (GO:0050908)2.43466156
184detection of light stimulus involved in sensory perception (GO:0050962)2.43466156
185regulation of respiratory burst (GO:0060263)2.41832161
186protein localization to Golgi apparatus (GO:0034067)2.41316522
187membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.39671231
188neuron fate determination (GO:0048664)2.36697037
189negative regulation of neurological system process (GO:0031645)2.36651189
190positive regulation of meiotic cell cycle (GO:0051446)2.35681390
191cellular response to leptin stimulus (GO:0044320)2.34896169
192indolalkylamine metabolic process (GO:0006586)2.33661454
193carbohydrate phosphorylation (GO:0046835)2.32928706
194glycerophospholipid catabolic process (GO:0046475)2.32246857
195positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.31661332
196axoneme assembly (GO:0035082)2.31431092
197regulation of hormone secretion (GO:0046883)2.31103939

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.27341352
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.67723384
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.91129000
4EP300_21415370_ChIP-Seq_HL-1_Mouse3.88314430
5* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.80373475
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.80216621
7TBX20_22328084_ChIP-Seq_HEART_Mouse3.40468164
8TBX20_22080862_ChIP-Seq_HEART_Mouse3.40468164
9RXR_22158963_ChIP-Seq_LIVER_Mouse3.01777485
10VDR_22108803_ChIP-Seq_LS180_Human2.99667375
11ZNF274_21170338_ChIP-Seq_K562_Hela2.99001970
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.97925632
13ZNF263_19887448_ChIP-Seq_K562_Human2.91936178
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.85922414
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.76065010
16GBX2_23144817_ChIP-Seq_PC3_Human2.66851785
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.66659318
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.64825425
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.60273865
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.52889080
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37937673
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35013768
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34037047
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33456515
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16498466
26MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.14903602
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03561881
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.01817798
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.94482697
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84703459
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84521374
32IGF1R_20145208_ChIP-Seq_DFB_Human1.82559540
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.79093875
34ER_23166858_ChIP-Seq_MCF-7_Human1.78825381
35P300_19829295_ChIP-Seq_ESCs_Human1.77745500
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.75248182
37CLOCK_20551151_ChIP-Seq_293T_Human1.72120332
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71702690
39PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.71415398
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71258214
41GATA4_21415370_ChIP-Seq_HL-1_Mouse1.69851808
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68981207
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68435985
44EZH2_22144423_ChIP-Seq_EOC_Human1.67550914
45SMAD4_21799915_ChIP-Seq_A2780_Human1.66730315
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.61028397
47AR_25329375_ChIP-Seq_VCAP_Human1.59842076
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54717860
49FUS_26573619_Chip-Seq_HEK293_Human1.52907356
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52234937
51CBP_20019798_ChIP-Seq_JUKART_Human1.52234937
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50216337
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.49023600
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.48467368
55REST_21632747_ChIP-Seq_MESCs_Mouse1.47152047
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46529303
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.46283824
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45064950
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44739959
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42926740
61TAF15_26573619_Chip-Seq_HEK293_Human1.42148541
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41669903
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.41219790
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41084941
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40901202
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40100408
67STAT3_23295773_ChIP-Seq_U87_Human1.39826747
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38489996
69TP53_22573176_ChIP-Seq_HFKS_Human1.38369963
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38192797
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37274414
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35265503
73SOX2_19829295_ChIP-Seq_ESCs_Human1.34606427
74NANOG_19829295_ChIP-Seq_ESCs_Human1.34606427
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33688495
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.32832325
77EWS_26573619_Chip-Seq_HEK293_Human1.32348239
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31357096
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.31134568
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30867036
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30016167
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29814826
83CDX2_22108803_ChIP-Seq_LS180_Human1.29449561
84DROSHA_22980978_ChIP-Seq_HELA_Human1.29244897
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.29230425
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28978293
87NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.27659883
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.27212003
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27212003
90TCF4_23295773_ChIP-Seq_U87_Human1.26812471
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25747404
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.25305791
93P53_22387025_ChIP-Seq_ESCs_Mouse1.24496822
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24385665
95TCF4_22108803_ChIP-Seq_LS180_Human1.23300342
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23112528
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23085601
98PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22976917
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22847761
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22563457
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.22295905
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21949523
103HTT_18923047_ChIP-ChIP_STHdh_Human1.21191170
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21054747
105FOXA2_19822575_ChIP-Seq_HepG2_Human1.19970066
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19176258
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17493366
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17488829
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17048369
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.16297898
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.16232170
112* LXR_22292898_ChIP-Seq_THP-1_Human1.15864500
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.15603883
114OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15489217
115STAT3_18555785_Chip-Seq_ESCs_Mouse1.12175932
116NCOR_22424771_ChIP-Seq_293T_Human1.11446617
117SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10665726
118GATA2_21666600_ChIP-Seq_HMVEC_Human1.10141713
119* CTCF_27219007_Chip-Seq_Bcells_Human1.09977153
120EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09959519
121REST_18959480_ChIP-ChIP_MESCs_Mouse1.09795345
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09639521
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09639521
124TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09455187
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08621068
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08447921
127TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08202448
128FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07441969
129AR_20517297_ChIP-Seq_VCAP_Human1.06601052
130CMYC_18555785_Chip-Seq_ESCs_Mouse1.06486971
131SOX2_21211035_ChIP-Seq_LN229_Gbm1.06302440
132GATA1_19941826_ChIP-Seq_K562_Human1.06102558
133MYC_19829295_ChIP-Seq_ESCs_Human1.05913533
134SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05408530
135* TP63_22573176_ChIP-Seq_HFKS_Human1.05372783
136E2F1_18555785_Chip-Seq_ESCs_Mouse1.04472307
137MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04194545
138RUNX2_22187159_ChIP-Seq_PCA_Human1.04027567
139MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03079600
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02319353
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01565567
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01309423
143GATA1_22025678_ChIP-Seq_K562_Human1.01131856
144CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01024869
145SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01024646
146PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00619896
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99709070
148STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99144066
149RACK7_27058665_Chip-Seq_MCF-7_Human0.97985618
150P68_20966046_ChIP-Seq_HELA_Human0.95035201
151RUNX1_27514584_Chip-Seq_MCF-7_Human0.92581221
152GATA2_19941826_ChIP-Seq_K562_Human0.92567921
153* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92404273
154TRIM28_21343339_ChIP-Seq_HEK293_Human0.91729918
155KDM2B_26808549_Chip-Seq_DND41_Human0.90959904
156GATA1_19941827_ChIP-Seq_MEL_Mouse0.89841175
157NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87420669
158SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84817265
159ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84128805
160CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82528989
161SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82344247
162ESR1_21235772_ChIP-Seq_MCF-7_Human0.81947218
163* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81919215
164ELK3_25401928_ChIP-Seq_HUVEC_Human0.81210517
165ATF3_27146783_Chip-Seq_COLON_Human0.81085179
166RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81065054
167ISL1_27105846_Chip-Seq_CPCs_Mouse0.80528043
168AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80132247
169SMC3_22415368_ChIP-Seq_MEFs_Mouse0.79911207
170OCT4_20526341_ChIP-Seq_ESCs_Human0.79185626
171SMAD3_21741376_ChIP-Seq_HESCs_Human0.79047035
172EGR1_19032775_ChIP-ChIP_M12_Human0.78984429
173SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.78933119
174SPI1_20517297_ChIP-Seq_HL60_Human0.77456734
175BCOR_27268052_Chip-Seq_Bcells_Human0.76956497
176SMAD4_21741376_ChIP-Seq_HESCs_Human0.76219263
177HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.75931745
178KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75257312
179BCAT_22108803_ChIP-Seq_LS180_Human0.74712226
180LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74174856
181DNAJC2_21179169_ChIP-ChIP_NT2_Human0.73824223
182BCL6_27268052_Chip-Seq_Bcells_Human0.73030851
183GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72056679
184GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72016585
185SMC4_20622854_ChIP-Seq_HELA_Human0.71939091
186MTF2_20144788_ChIP-Seq_MESCs_Mouse0.70182710
187FOXO3_23340844_ChIP-Seq_DLD1_Human0.70092347
188SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69226002
189CREB1_26743006_Chip-Seq_LNCaP_Human0.69137740
190KDM2B_26808549_Chip-Seq_K562_Human0.69027848
191GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.68967468
192WT1_25993318_ChIP-Seq_PODOCYTE_Human0.68844123
193FOXH1_21741376_ChIP-Seq_ESCs_Human0.68683636
194BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68234286
195UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.67722675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.22540204
2MP0003646_muscle_fatigue5.87642283
3MP0004084_abnormal_cardiac_muscle5.41408348
4MP0000751_myopathy4.90175259
5MP0004215_abnormal_myocardial_fiber4.67688506
6MP0004036_abnormal_muscle_relaxation3.94207844
7MP0005330_cardiomyopathy3.75308560
8MP0000749_muscle_degeneration3.41866683
9MP0003283_abnormal_digestive_organ3.17870624
10MP0002972_abnormal_cardiac_muscle2.99657547
11MP0004087_abnormal_muscle_fiber2.85155032
12MP0008775_abnormal_heart_ventricle2.84405210
13MP0003137_abnormal_impulse_conducting2.80522837
14MP0004130_abnormal_muscle_cell2.72154839
15MP0000750_abnormal_muscle_regeneration2.59515291
16MP0003787_abnormal_imprinting2.57858749
17MP0001544_abnormal_cardiovascular_syste2.57148170
18MP0005385_cardiovascular_system_phenoty2.57148170
19MP0002163_abnormal_gland_morphology2.48999389
20MP0005620_abnormal_muscle_contractility2.47719756
21MP0010630_abnormal_cardiac_muscle2.44167852
22MP0006138_congestive_heart_failure2.41874657
23MP0004484_altered_response_of2.39867959
24MP0001944_abnormal_pancreas_morphology2.22307482
25MP0002693_abnormal_pancreas_physiology2.22159470
26MP0002106_abnormal_muscle_physiology2.20711315
27MP0002269_muscular_atrophy2.13799642
28MP0005379_endocrine/exocrine_gland_phen2.10657412
29MP0004085_abnormal_heartbeat2.06878142
30MP0003828_pulmonary_edema2.00888568
31MP0008877_abnormal_DNA_methylation1.97148859
32MP0006072_abnormal_retinal_apoptosis1.95773175
33MP0006036_abnormal_mitochondrial_physio1.87392246
34MP0003221_abnormal_cardiomyocyte_apopto1.83481392
35MP0005670_abnormal_white_adipose1.82283049
36MP0005666_abnormal_adipose_tissue1.80979465
37MP0003122_maternal_imprinting1.79892549
38MP0005645_abnormal_hypothalamus_physiol1.78942055
39MP0005369_muscle_phenotype1.78103935
40MP0001986_abnormal_taste_sensitivity1.78055702
41MP0002102_abnormal_ear_morphology1.76769201
42MP0008872_abnormal_physiological_respon1.74526245
43MP0009046_muscle_twitch1.73944401
44MP0002638_abnormal_pupillary_reflex1.73346408
45MP0000747_muscle_weakness1.73136973
46MP0003011_delayed_dark_adaptation1.72519635
47MP0010234_abnormal_vibrissa_follicle1.71923850
48MP0000759_abnormal_skeletal_muscle1.71492323
49MP0004510_myositis1.70559810
50MP0001984_abnormal_olfaction1.65250686
51MP0002876_abnormal_thyroid_physiology1.63614845
52MP0004885_abnormal_endolymph1.62501836
53MP0004142_abnormal_muscle_tone1.54703599
54MP0009745_abnormal_behavioral_response1.54418073
55MP0002277_abnormal_respiratory_mucosa1.52524949
56MP0004145_abnormal_muscle_electrophysio1.50270864
57MP0000427_abnormal_hair_cycle1.48462342
58MP0005551_abnormal_eye_electrophysiolog1.47422261
59MP0004270_analgesia1.47133787
60MP0002938_white_spotting1.45089697
61MP0002127_abnormal_cardiovascular_syste1.42949366
62MP0005253_abnormal_eye_physiology1.42020579
63MP0005220_abnormal_exocrine_pancreas1.41408531
64MP0004233_abnormal_muscle_weight1.41300563
65MP0001501_abnormal_sleep_pattern1.33143530
66MP0002332_abnormal_exercise_endurance1.32588269
67MP0002064_seizures1.30948725
68MP0005085_abnormal_gallbladder_physiolo1.30283567
69MP0002928_abnormal_bile_duct1.29822788
70MP0005646_abnormal_pituitary_gland1.27872193
71MP0005360_urolithiasis1.27502811
72MP0003806_abnormal_nucleotide_metabolis1.27296808
73MP0000569_abnormal_digit_pigmentation1.25796639
74MP0003950_abnormal_plasma_membrane1.23784533
75MP0002272_abnormal_nervous_system1.20800749
76MP0001968_abnormal_touch/_nociception1.18760059
77MP0000343_altered_response_to1.17893013
78MP0005375_adipose_tissue_phenotype1.16458239
79MP0005448_abnormal_energy_balance1.15551878
80MP0004185_abnormal_adipocyte_glucose1.15537557
81MP0005165_increased_susceptibility_to1.15349565
82MP0010368_abnormal_lymphatic_system1.11621790
83MP0000631_abnormal_neuroendocrine_gland1.07095418
84MP0005075_abnormal_melanosome_morpholog1.06703163
85MP0001756_abnormal_urination1.05630048
86MP0000372_irregular_coat_pigmentation1.05597558
87MP0002138_abnormal_hepatobiliary_system1.04488476
88MP0006035_abnormal_mitochondrial_morpho1.02387676
89MP0002557_abnormal_social/conspecific_i1.01417356
90MP0004043_abnormal_pH_regulation1.01342662
91MP0000266_abnormal_heart_morphology1.00838052
92MP0005636_abnormal_mineral_homeostasis1.00513294
93MP0003279_aneurysm1.00151393
94MP0000516_abnormal_urinary_system0.99855695
95MP0005367_renal/urinary_system_phenotyp0.99855695
96MP0009840_abnormal_foam_cell0.97944957
97MP0001764_abnormal_homeostasis0.97741202
98MP0000230_abnormal_systemic_arterial0.97225403
99MP0003567_abnormal_fetal_cardiomyocyte0.96647639
100MP0001440_abnormal_grooming_behavior0.95831005
101MP0003633_abnormal_nervous_system0.95599363
102MP0002254_reproductive_system_inflammat0.95268364
103MP0002139_abnormal_hepatobiliary_system0.93011477
104MP0003123_paternal_imprinting0.92466384
105MP0005332_abnormal_amino_acid0.90997751
106MP0003121_genomic_imprinting0.89833244
107MP0002234_abnormal_pharynx_morphology0.89804220
108MP0003705_abnormal_hypodermis_morpholog0.89570636
109MP0005266_abnormal_metabolism0.89384558
110MP0002160_abnormal_reproductive_system0.89266047
111MP0002734_abnormal_mechanical_nocicepti0.89146376
112MP0002572_abnormal_emotion/affect_behav0.89015997
113MP0003953_abnormal_hormone_level0.87710361
114MP0004133_heterotaxia0.87189145
115MP0005365_abnormal_bile_salt0.87041638
116MP0001905_abnormal_dopamine_level0.86401857
117MP0003195_calcinosis0.83798174
118MP0005451_abnormal_body_composition0.83628080
119MP0005319_abnormal_enzyme/_coenzyme0.82780960
120MP0002229_neurodegeneration0.82263281
121MP0003045_fibrosis0.80020886
122MP0001485_abnormal_pinna_reflex0.79637998
123MP0005389_reproductive_system_phenotype0.77293535
124MP0001486_abnormal_startle_reflex0.77279817
125MP0003252_abnormal_bile_duct0.76957783
126MP0004134_abnormal_chest_morphology0.76551685
127MP0001970_abnormal_pain_threshold0.74367606
128MP0002128_abnormal_blood_circulation0.74181560
129MP0002971_abnormal_brown_adipose0.73826646
130MP0002118_abnormal_lipid_homeostasis0.73086560
131MP0002108_abnormal_muscle_morphology0.72623696
132MP0008875_abnormal_xenobiotic_pharmacok0.72243570
133MP0005083_abnormal_biliary_tract0.70522466
134MP0002909_abnormal_adrenal_gland0.69770935
135MP0002078_abnormal_glucose_homeostasis0.66562522
136MP0010329_abnormal_lipoprotein_level0.65348467
137MP0005535_abnormal_body_temperature0.61967123
138MP0000003_abnormal_adipose_tissue0.61836992
139MP0003566_abnormal_cell_adhesion0.61570478
140MP0002822_catalepsy0.61247757
141MP0005623_abnormal_meninges_morphology0.60431589
142MP0004147_increased_porphyrin_level0.57756519
143MP0008961_abnormal_basal_metabolism0.57411464
144MP0005584_abnormal_enzyme/coenzyme_acti0.56085575
145MP0001879_abnormal_lymphatic_vessel0.54840880
146MP0009643_abnormal_urine_homeostasis0.51946358
147MP0005187_abnormal_penis_morphology0.51828350
148MP0000767_abnormal_smooth_muscle0.49696494
149MP0005334_abnormal_fat_pad0.49274184
150MP0009780_abnormal_chondrocyte_physiolo0.48126416
151MP0000013_abnormal_adipose_tissue0.45795649
152MP0003191_abnormal_cellular_cholesterol0.45487038
153MP0009384_cardiac_valve_regurgitation0.45362217
154MP0005167_abnormal_blood-brain_barrier0.43849542
155MP0000609_abnormal_liver_physiology0.41322418
156MP0001765_abnormal_ion_homeostasis0.36568160
157MP0009115_abnormal_fat_cell0.35687523
158MP0005595_abnormal_vascular_smooth0.33236083
159MP0003656_abnormal_erythrocyte_physiolo0.32944057
160MP0008438_abnormal_cutaneous_collagen0.31713697
161MP0005376_homeostasis/metabolism_phenot0.31515625
162MP0001853_heart_inflammation0.31510479
163MP0004924_abnormal_behavior0.30164651
164MP0005386_behavior/neurological_phenoty0.30164651
165MP0004272_abnormal_basement_membrane0.30095536

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.71702580
2Ventricular tachycardia (HP:0004756)6.79306935
3Hypoglycemic seizures (HP:0002173)6.62664600
4Calf muscle hypertrophy (HP:0008981)5.99880646
5Atrial fibrillation (HP:0005110)5.82893896
6Primary atrial arrhythmia (HP:0001692)5.43834260
7Muscle hypertrophy of the lower extremities (HP:0008968)5.39777108
8Exercise-induced myalgia (HP:0003738)5.25671432
9Supraventricular tachycardia (HP:0004755)5.25308513
10Exercise-induced muscle cramps (HP:0003710)5.23696950
11Muscle fiber splitting (HP:0003555)5.23597792
12Supraventricular arrhythmia (HP:0005115)5.14073292
13Lipoatrophy (HP:0100578)5.11400823
14Hyperglycemia (HP:0003074)5.05400004
15Myoglobinuria (HP:0002913)4.99162179
16Right ventricular cardiomyopathy (HP:0011663)4.95983988
17Abnormality of the pancreatic islet cells (HP:0006476)4.95978859
18Abnormality of endocrine pancreas physiology (HP:0012093)4.95978859
19Abnormality of the calf musculature (HP:0001430)4.83710937
20Bundle branch block (HP:0011710)4.65722029
21Syncope (HP:0001279)4.61919508
22Symptomatic seizures (HP:0011145)4.58685771
23Palpitations (HP:0001962)4.51758219
24Hyporeflexia of lower limbs (HP:0002600)4.51557805
25Dilated cardiomyopathy (HP:0001644)4.38955384
26Subaortic stenosis (HP:0001682)4.22961609
27Abnormality of the left ventricular outflow tract (HP:0011103)4.22961609
28Heart block (HP:0012722)4.08041151
29Atrioventricular block (HP:0001678)4.07657676
30Prolonged QT interval (HP:0001657)4.00794491
31Abnormal atrioventricular conduction (HP:0005150)3.83934175
32Asymmetric septal hypertrophy (HP:0001670)3.80242055
33Ventricular arrhythmia (HP:0004308)3.76015214
34Increased connective tissue (HP:0009025)3.75502971
35Rhabdomyolysis (HP:0003201)3.74801280
36EMG: myopathic abnormalities (HP:0003458)3.69909466
37Late onset (HP:0003584)3.64316341
38Ketoacidosis (HP:0001993)3.64229624
39Hypoglycemic coma (HP:0001325)3.48433524
40Hypomagnesemia (HP:0002917)3.48037544
41Prominent metopic ridge (HP:0005487)3.45442265
42Ventricular fibrillation (HP:0001663)3.39479749
43Abnormality of fatty-acid metabolism (HP:0004359)3.35704735
44Hepatic necrosis (HP:0002605)3.30447733
45Difficulty running (HP:0009046)3.25356796
46Abnormality of the metopic suture (HP:0005556)3.18790346
47Myotonia (HP:0002486)3.16229061
48Hemiparesis (HP:0001269)3.16107865
49Abnormality of dicarboxylic acid metabolism (HP:0010995)3.11698611
50Dicarboxylic aciduria (HP:0003215)3.11698611
51Neoplasm of the adrenal cortex (HP:0100641)3.08524072
52Ketosis (HP:0001946)3.03248158
53Hypothermia (HP:0002045)2.99206592
54Abnormal mitochondria in muscle tissue (HP:0008316)2.88467605
55Abnormal drinking behavior (HP:0030082)2.88128317
56Polydipsia (HP:0001959)2.88128317
57Abnormal EKG (HP:0003115)2.82816897
58Muscle fiber inclusion bodies (HP:0100299)2.79569209
59Acute necrotizing encephalopathy (HP:0006965)2.79215555
60Increased muscle lipid content (HP:0009058)2.76678556
61EEG with generalized epileptiform discharges (HP:0011198)2.76643825
62Hypsarrhythmia (HP:0002521)2.76582798
63Epileptiform EEG discharges (HP:0011182)2.75288974
64Cerebral edema (HP:0002181)2.74967101
65Hyperventilation (HP:0002883)2.72164133
66Hepatocellular necrosis (HP:0001404)2.71393821
67Left ventricular hypertrophy (HP:0001712)2.70735190
68Hyperglycinuria (HP:0003108)2.68659088
69Abnormality of magnesium homeostasis (HP:0004921)2.67471954
70Nemaline bodies (HP:0003798)2.67457475
71Difficulty climbing stairs (HP:0003551)2.66853506
72Acute encephalopathy (HP:0006846)2.66748813
73Insulin-resistant diabetes mellitus (HP:0000831)2.64998045
74Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.60352424
75Palmoplantar keratoderma (HP:0000982)2.59732540
76Testicular atrophy (HP:0000029)2.59344300
77Distal lower limb muscle weakness (HP:0009053)2.57252740
78Hyperammonemia (HP:0001987)2.53855140
79Abnormality of the renal cortex (HP:0011035)2.52717364
80Pancreatic cysts (HP:0001737)2.51262366
81Type I diabetes mellitus (HP:0100651)2.48193034
82Conjunctival hamartoma (HP:0100780)2.42961760
83Generalized aminoaciduria (HP:0002909)2.42112702
84Congenital stationary night blindness (HP:0007642)2.41029045
85Pancreatic islet-cell hyperplasia (HP:0004510)2.40849577
86Hepatoblastoma (HP:0002884)2.40041291
87Limb-girdle muscle atrophy (HP:0003797)2.39526077
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.37501795
89Enlarged penis (HP:0000040)2.33574658
90Mitochondrial inheritance (HP:0001427)2.31638121
91Progressive macrocephaly (HP:0004481)2.31047617
92Increased circulating renin level (HP:0000848)2.30483107
93Hematochezia (HP:0002573)2.29815193
94Muscle stiffness (HP:0003552)2.28534982
95Febrile seizures (HP:0002373)2.28055876
96Thyroiditis (HP:0100646)2.27767827
97Increased intramyocellular lipid droplets (HP:0012240)2.27572011
98Molar tooth sign on MRI (HP:0002419)2.26693780
99Abnormality of midbrain morphology (HP:0002418)2.26693780
100Abnormality of glycine metabolism (HP:0010895)2.26507991
101Abnormality of serine family amino acid metabolism (HP:0010894)2.26507991
102Ragged-red muscle fibers (HP:0003200)2.25500300
103Hyperinsulinemic hypoglycemia (HP:0000825)2.25275449
104Lactic acidosis (HP:0003128)2.24864331
105Increased variability in muscle fiber diameter (HP:0003557)2.23534550
106Increased CSF lactate (HP:0002490)2.21689538
107Gaze-evoked nystagmus (HP:0000640)2.21675844
108Dysmetric saccades (HP:0000641)2.20980344
109Progressive inability to walk (HP:0002505)2.20308809
110Nephronophthisis (HP:0000090)2.18534068
111Pancreatic fibrosis (HP:0100732)2.16688458
112Pheochromocytoma (HP:0002666)2.15901707
113Abnormal rod and cone electroretinograms (HP:0008323)2.15412438
114Abnormal pancreas size (HP:0012094)2.15073842
115Downturned corners of mouth (HP:0002714)2.10483058
116Broad-based gait (HP:0002136)2.08419265
117Polyuria (HP:0000103)2.08190317
118Respiratory failure (HP:0002878)2.07843918
119Tongue fasciculations (HP:0001308)2.05921448
120Areflexia of lower limbs (HP:0002522)2.04688269
121Tetany (HP:0001281)2.03847756
122Sudden cardiac death (HP:0001645)2.02972249
123Hamartoma of the eye (HP:0010568)2.01629933
124Neoplasm of head and neck (HP:0012288)1.99845450
125Esophageal neoplasm (HP:0100751)1.99845450
126Congestive heart failure (HP:0001635)1.99467003
127Nausea (HP:0002018)1.99247028
128Furrowed tongue (HP:0000221)1.98604924
129Renal cortical cysts (HP:0000803)1.95387249
130Abnormality of skeletal muscle fiber size (HP:0012084)1.94609852
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94495230
132Abnormality of alanine metabolism (HP:0010916)1.94495230
133Hyperalaninemia (HP:0003348)1.94495230
134Exercise intolerance (HP:0003546)1.94394423
135Distal lower limb amyotrophy (HP:0008944)1.94179191
136True hermaphroditism (HP:0010459)1.93937603
137Abnormality of the renal medulla (HP:0100957)1.93387966
138Neuroendocrine neoplasm (HP:0100634)1.92274143
139Metabolic acidosis (HP:0001942)1.91516176
140Intestinal atresia (HP:0011100)1.91038266
141Large for gestational age (HP:0001520)1.90108082
142Hypoalphalipoproteinemia (HP:0003233)1.90062176
143Methylmalonic acidemia (HP:0002912)1.87422889
144Abnormality of the foot musculature (HP:0001436)1.87137892
145Severe muscular hypotonia (HP:0006829)1.85787325
146Abnormality of renin-angiotensin system (HP:0000847)1.85576742
147Muscular hypotonia of the trunk (HP:0008936)1.85116296
148Neoplasm of the adrenal gland (HP:0100631)1.84935115
149Proximal tubulopathy (HP:0000114)1.84809194
150Cholelithiasis (HP:0001081)1.84492375
151Neck muscle weakness (HP:0000467)1.84228968
152Lethargy (HP:0001254)1.84186113
153Inability to walk (HP:0002540)1.83938236
154Athetosis (HP:0002305)1.83714498
155Lymphangioma (HP:0100764)1.83016008
156Hypoalbuminemia (HP:0003073)1.82507705
157Abnormal albumin level (HP:0012116)1.82507705
158Attenuation of retinal blood vessels (HP:0007843)1.82207175
159Foot dorsiflexor weakness (HP:0009027)1.80544176
160Decreased circulating renin level (HP:0003351)1.80352166
161Facial diplegia (HP:0001349)1.78085727
162Agitation (HP:0000713)1.77841720
163Abnormal urine output (HP:0012590)1.77192975
164Muscle fibrillation (HP:0010546)1.76008665
165Delayed CNS myelination (HP:0002188)1.75264797
166Focal seizures (HP:0007359)1.74052084
167Enlarged kidneys (HP:0000105)1.72366779
168Abolished electroretinogram (ERG) (HP:0000550)1.68468760
169Hypokalemia (HP:0002900)1.68068661
170Methylmalonic aciduria (HP:0012120)1.66994730
171Abnormality of urine glucose concentration (HP:0011016)1.66570566
172Glycosuria (HP:0003076)1.66570566
173Type II lissencephaly (HP:0007260)1.66386008
174Ulnar claw (HP:0001178)1.66030115
175Dialeptic seizures (HP:0011146)1.65016028
176Abnormality of vitamin B metabolism (HP:0004340)1.61068753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.74000323
2TTN5.92253892
3LMTK24.38035212
4PHKG13.90520873
5PHKG23.90520873
6FGFR23.68602147
7MYLK3.62077545
8PDK33.56147252
9PDK43.56147252
10BCKDK3.41686061
11OBSCN3.04666101
12PKN22.84731547
13TRIB32.84350137
14DMPK2.71404495
15PIK3CA2.33145713
16PDK22.26422981
17MUSK2.25614302
18PINK12.21342262
19BMPR1B2.19895708
20ADRBK22.17453158
21ACVR1B2.11052436
22NEK12.05668455
23DAPK22.05281099
24TIE12.01565597
25TNIK1.86126683
26GRK11.74654307
27NUAK11.69569270
28PASK1.66690610
29WNK31.65680968
30MAP4K21.64199814
31PAK31.54237579
32STK241.53124991
33CASK1.53081452
34GRK71.46750459
35OXSR11.46686592
36WNK41.43404385
37NLK1.36804873
38PRKD11.34252099
39MAP2K61.33775468
40CAMK2D1.28574337
41MAP3K41.19045635
42FGFR31.18969171
43INSRR1.11384601
44MAP3K71.09894620
45TAOK31.09153809
46RIPK11.07339962
47MST41.07018607
48NTRK31.05389367
49MAPK121.04733175
50STK38L1.03391661
51CAMKK21.03364599
52STK31.01754379
53CSNK1G11.01488462
54PRKAA20.96509149
55STK40.96284664
56PRKAA10.95282773
57STK160.93303904
58TLK10.92626564
59ROCK10.91777435
60MAPK130.90285932
61SIK10.89126321
62MAP3K50.85104307
63PKN10.84850857
64ILK0.84651678
65MAP3K20.84216903
66CDC42BPA0.83649324
67CAMK40.81920542
68STK380.78750758
69MAPKAPK30.76732942
70FLT30.76675608
71HIPK20.75571636
72PDGFRA0.74990673
73DAPK30.73158238
74PRKCG0.72263727
75STK110.71454272
76EPHB10.70300078
77PIK3CG0.69188790
78CSNK1G30.67968679
79ADRBK10.66598638
80CSNK1G20.65289118
81MAP2K30.65079280
82TXK0.63565137
83ERBB30.63350716
84TGFBR20.62205819
85CAMK2A0.61747670
86KDR0.60380220
87WNK10.57976244
88RPS6KC10.57180880
89RPS6KL10.57180880
90FGFR40.57092592
91ROCK20.55403201
92PDPK10.55059295
93CAMK10.54355807
94TRPM70.54292995
95IRAK10.54165755
96IKBKB0.54054469
97MAP2K70.53725609
98MARK10.52017301
99TRIM280.51875673
100PRKCE0.51282302
101MAP3K30.51269862
102PTK60.50337776
103PLK20.50133504
104PRKACG0.49672108
105TGFBR10.49254946
106PRKACB0.48959725
107RPS6KA60.48658395
108ZAK0.47871217
109CSNK1A1L0.47107115
110PLK30.46830951
111ERN10.44098943
112TNK20.43609796
113PDK10.43583370
114STK390.43224220
115PNCK0.41803699
116PRKACA0.41446722
117PRKCH0.41257690
118ICK0.40960647
119PRKCZ0.40182370
120SGK4940.39794107
121SGK2230.39794107
122CSNK1A10.39705279
123SGK30.39667988
124PTK2B0.39181211
125CAMK2G0.37919564
126JAK10.36229633
127NTRK20.34741452
128NEK90.34403558
129CAMK1D0.34060108
130MKNK20.32223308
131CDK30.31646386
132LATS10.31210520
133EPHA30.31008607
134PRKCA0.30932364
135DYRK20.30630512
136AKT20.29953515
137CSNK1D0.28392655
138NME20.27756553
139GSK3A0.27245856
140RPS6KA10.26976285
141RET0.26880692
142ITK0.26864268
143MAPK110.26515005
144PRKG20.26350363
145FER0.24930833
146RPS6KA50.24557256
147MAPK70.23183829
148CAMK1G0.23003623
149JAK20.22157630
150TAOK10.21602396
151SGK10.20608205
152MTOR0.20252211
153EPHB20.19200514
154MAP3K10.18501486
155MAP2K40.18420616
156PRKD30.17895808
157SGK20.17121301
158RPS6KA30.16193166
159PAK60.14148463
160PRKG10.13647705
161PRKD20.12808536

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.25298163
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.35161608
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.27549384
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.75819198
5Propanoate metabolism_Homo sapiens_hsa006403.68592630
6Fatty acid degradation_Homo sapiens_hsa000713.46608181
7Cardiac muscle contraction_Homo sapiens_hsa042603.34838737
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.94579620
9Dilated cardiomyopathy_Homo sapiens_hsa054142.84002998
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.70881141
11Fatty acid metabolism_Homo sapiens_hsa012122.63826103
12Carbon metabolism_Homo sapiens_hsa012002.50993793
13Parkinsons disease_Homo sapiens_hsa050122.49323344
14Oxidative phosphorylation_Homo sapiens_hsa001902.47256976
15Regulation of autophagy_Homo sapiens_hsa041402.23711711
16Butanoate metabolism_Homo sapiens_hsa006502.15845118
17Protein export_Homo sapiens_hsa030602.14333278
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.11952102
19Pyruvate metabolism_Homo sapiens_hsa006202.04137766
20Linoleic acid metabolism_Homo sapiens_hsa005911.84330558
21Alzheimers disease_Homo sapiens_hsa050101.83144391
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77059282
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76017702
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75967604
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71287166
26PPAR signaling pathway_Homo sapiens_hsa033201.70915197
27Phototransduction_Homo sapiens_hsa047441.60364901
28Tryptophan metabolism_Homo sapiens_hsa003801.59929460
29Fatty acid elongation_Homo sapiens_hsa000621.56169486
30Arginine biosynthesis_Homo sapiens_hsa002201.53245748
31Type I diabetes mellitus_Homo sapiens_hsa049401.49658279
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46581378
33Huntingtons disease_Homo sapiens_hsa050161.45538850
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29219219
35beta-Alanine metabolism_Homo sapiens_hsa004101.24531165
36Biosynthesis of amino acids_Homo sapiens_hsa012301.23600108
37Starch and sucrose metabolism_Homo sapiens_hsa005001.22456562
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22249924
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21939496
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21235913
41Ether lipid metabolism_Homo sapiens_hsa005651.21047864
42Viral myocarditis_Homo sapiens_hsa054161.19918182
43Peroxisome_Homo sapiens_hsa041461.18577885
44Collecting duct acid secretion_Homo sapiens_hsa049661.18483334
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14478851
46Lysine degradation_Homo sapiens_hsa003101.07227761
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98632581
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98368068
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96402700
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95644145
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.95033932
52Nitrogen metabolism_Homo sapiens_hsa009100.94854228
53Insulin resistance_Homo sapiens_hsa049310.93083749
54Mineral absorption_Homo sapiens_hsa049780.91917236
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87573543
56Arginine and proline metabolism_Homo sapiens_hsa003300.86470204
57Phenylalanine metabolism_Homo sapiens_hsa003600.82851308
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.82723279
59Glucagon signaling pathway_Homo sapiens_hsa049220.81209184
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80099469
61Fatty acid biosynthesis_Homo sapiens_hsa000610.78450565
62Circadian entrainment_Homo sapiens_hsa047130.77299260
63Arachidonic acid metabolism_Homo sapiens_hsa005900.74793344
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.74790193
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72767374
66Bile secretion_Homo sapiens_hsa049760.71027107
67mTOR signaling pathway_Homo sapiens_hsa041500.69482330
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68552038
69Nicotine addiction_Homo sapiens_hsa050330.67841305
70Salivary secretion_Homo sapiens_hsa049700.67292021
71Vitamin B6 metabolism_Homo sapiens_hsa007500.66202764
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66047877
73Insulin signaling pathway_Homo sapiens_hsa049100.65925363
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65137126
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64843752
76Fat digestion and absorption_Homo sapiens_hsa049750.64218606
77Taste transduction_Homo sapiens_hsa047420.62583672
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62394561
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62151781
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58003606
81AMPK signaling pathway_Homo sapiens_hsa041520.56938652
82Olfactory transduction_Homo sapiens_hsa047400.56736814
83GABAergic synapse_Homo sapiens_hsa047270.55067319
84Galactose metabolism_Homo sapiens_hsa000520.53643428
85Type II diabetes mellitus_Homo sapiens_hsa049300.52851635
86Fructose and mannose metabolism_Homo sapiens_hsa000510.50117671
87Tyrosine metabolism_Homo sapiens_hsa003500.49756622
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.49581187
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49561490
90Amphetamine addiction_Homo sapiens_hsa050310.48539176
91Morphine addiction_Homo sapiens_hsa050320.46512639
92Serotonergic synapse_Homo sapiens_hsa047260.45337447
93Calcium signaling pathway_Homo sapiens_hsa040200.44607867
94Dopaminergic synapse_Homo sapiens_hsa047280.44380548
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44302638
96Vitamin digestion and absorption_Homo sapiens_hsa049770.42353708
97Glutamatergic synapse_Homo sapiens_hsa047240.42003203
98Glycerolipid metabolism_Homo sapiens_hsa005610.39121258
99HIF-1 signaling pathway_Homo sapiens_hsa040660.37441277
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37120046
101Metabolic pathways_Homo sapiens_hsa011000.36499523
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35429920
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34727569
104One carbon pool by folate_Homo sapiens_hsa006700.34507968
105Caffeine metabolism_Homo sapiens_hsa002320.33853512
106Focal adhesion_Homo sapiens_hsa045100.33592035
107ABC transporters_Homo sapiens_hsa020100.33520152
108Synaptic vesicle cycle_Homo sapiens_hsa047210.33255856
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32510857
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.32072565
111Histidine metabolism_Homo sapiens_hsa003400.32070479
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.31576778
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30946146
114Sulfur metabolism_Homo sapiens_hsa009200.30372951
115Basal transcription factors_Homo sapiens_hsa030220.30029621
116Gastric acid secretion_Homo sapiens_hsa049710.29607510
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29246051
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25714029
119cAMP signaling pathway_Homo sapiens_hsa040240.25425972
120Renin secretion_Homo sapiens_hsa049240.25186604
121Oxytocin signaling pathway_Homo sapiens_hsa049210.23273552
122Insulin secretion_Homo sapiens_hsa049110.23214982
123ECM-receptor interaction_Homo sapiens_hsa045120.19992829
124Chemical carcinogenesis_Homo sapiens_hsa052040.19005495
125Pentose phosphate pathway_Homo sapiens_hsa000300.17768948
126Tight junction_Homo sapiens_hsa045300.16989486
127Complement and coagulation cascades_Homo sapiens_hsa046100.15493649
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14299565
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14232658
130Amoebiasis_Homo sapiens_hsa051460.12139913
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.11388493
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.10368864
133Ovarian steroidogenesis_Homo sapiens_hsa049130.09783943
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07942121
135Selenocompound metabolism_Homo sapiens_hsa004500.07428545
136Pancreatic secretion_Homo sapiens_hsa049720.06779370
137Glutathione metabolism_Homo sapiens_hsa004800.05891250
138Circadian rhythm_Homo sapiens_hsa047100.05872570
139Dorso-ventral axis formation_Homo sapiens_hsa043200.05757445
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05564660
141Retinol metabolism_Homo sapiens_hsa008300.04228881
142Adherens junction_Homo sapiens_hsa045200.03138475

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