SLC25A37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1porphyrin-containing compound metabolic process (GO:0006778)9.48695221
2erythrocyte maturation (GO:0043249)9.39641576
3heme metabolic process (GO:0042168)8.86574616
4hemoglobin metabolic process (GO:0020027)8.63183151
5response to methylmercury (GO:0051597)6.95250493
6erythrocyte development (GO:0048821)6.90138802
7negative regulation of cell killing (GO:0031342)6.23087109
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.23087109
9tetrapyrrole metabolic process (GO:0033013)6.07761600
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.97417646
11response to lead ion (GO:0010288)5.70419346
12positive regulation by organism of defense response of other organism involved in symbiotic interact5.70049637
13modulation by symbiont of host immune response (GO:0052553)5.70049637
14positive regulation by symbiont of host defense response (GO:0052509)5.70049637
15modulation by symbiont of host defense response (GO:0052031)5.70049637
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.70049637
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.70049637
18response to insecticide (GO:0017085)5.40971189
19regulation of B cell receptor signaling pathway (GO:0050855)5.35711762
20erythrocyte differentiation (GO:0030218)5.20267862
21microglial cell activation (GO:0001774)5.10409055
22myeloid cell development (GO:0061515)4.95989553
23pigment biosynthetic process (GO:0046148)4.94603381
24detection of molecule of bacterial origin (GO:0032490)4.94362586
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.77856129
26oxygen transport (GO:0015671)4.69538897
27neutrophil activation involved in immune response (GO:0002283)4.68043944
28macrophage activation involved in immune response (GO:0002281)4.66663885
29very-low-density lipoprotein particle assembly (GO:0034379)4.62557013
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.53865336
31detection of other organism (GO:0098543)4.49717607
32negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.49097783
33antigen processing and presentation of endogenous antigen (GO:0019883)4.47963694
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.44379743
35regulation of response to osmotic stress (GO:0047484)4.43508723
36regulation of gamma-delta T cell activation (GO:0046643)4.41848712
37response to arsenic-containing substance (GO:0046685)4.36791340
38cellular extravasation (GO:0045123)4.35390345
39detection of external biotic stimulus (GO:0098581)4.33625932
40neutrophil mediated immunity (GO:0002446)4.26272616
41negative regulation of lymphocyte mediated immunity (GO:0002707)4.26175793
42regulation of cytokine secretion involved in immune response (GO:0002739)4.20097243
43regulation of gamma-delta T cell differentiation (GO:0045586)4.20056145
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.17757530
45plasma lipoprotein particle assembly (GO:0034377)4.14537082
46pigment metabolic process (GO:0042440)4.12486792
47detection of bacterium (GO:0016045)4.10393913
48macrophage activation (GO:0042116)4.06903071
49response to interleukin-15 (GO:0070672)4.01831738
50iron ion import (GO:0097286)3.92310093
51response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.89864506
52response to host immune response (GO:0052572)3.89864506
53negative regulation of interleukin-12 production (GO:0032695)3.88163160
54leukocyte aggregation (GO:0070486)3.85822497
55neutrophil activation (GO:0042119)3.85600943
56regulation of interferon-beta biosynthetic process (GO:0045357)3.85303358
57negative regulation of T cell mediated immunity (GO:0002710)3.83741592
58response to peptidoglycan (GO:0032494)3.82991419
59negative regulation of viral entry into host cell (GO:0046597)3.81005608
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.80791112
61myeloid leukocyte mediated immunity (GO:0002444)3.76874353
62bicarbonate transport (GO:0015701)3.75724880
63embryonic hemopoiesis (GO:0035162)3.74042383
64protein-lipid complex assembly (GO:0065005)3.73252647
65regulation of DNA endoreduplication (GO:0032875)3.73195930
66detection of biotic stimulus (GO:0009595)3.72631618
67leukocyte migration involved in inflammatory response (GO:0002523)3.72141417
68definitive hemopoiesis (GO:0060216)3.68760000
69mitotic sister chromatid segregation (GO:0000070)3.64320759
70respiratory burst (GO:0045730)3.63099479
71positive regulation of granulocyte differentiation (GO:0030854)3.62713355
72response to host (GO:0075136)3.59780548
73response to host defenses (GO:0052200)3.59780548
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.59780548
75negative regulation of erythrocyte differentiation (GO:0045647)3.57571119
76myeloid cell activation involved in immune response (GO:0002275)3.57047716
77negative regulation of leukocyte mediated immunity (GO:0002704)3.56076071
78sister chromatid segregation (GO:0000819)3.55355079
79one-carbon compound transport (GO:0019755)3.54811286
80L-alpha-amino acid transmembrane transport (GO:1902475)3.53001293
81B cell receptor signaling pathway (GO:0050853)3.49373754
82megakaryocyte development (GO:0035855)3.48055563
83platelet formation (GO:0030220)3.47862002
84cellular response to interleukin-15 (GO:0071350)3.46435580
85negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.45846406
86regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.45837553
87granulocyte activation (GO:0036230)3.44378063
88positive thymic T cell selection (GO:0045059)3.42642172
89negative T cell selection (GO:0043383)3.37340304
90negative thymic T cell selection (GO:0045060)3.35872845
913-UTR-mediated mRNA stabilization (GO:0070935)3.30900716
92positive regulation of erythrocyte differentiation (GO:0045648)3.30472529
93DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.30255211
94mitotic chromosome condensation (GO:0007076)3.29800948
95actin filament capping (GO:0051693)3.29039499
96regulation of B cell differentiation (GO:0045577)3.28511366
97positive T cell selection (GO:0043368)3.27123461
98regulation of mast cell degranulation (GO:0043304)3.21091524
99positive regulation of B cell differentiation (GO:0045579)3.19705031
100regulation of necroptotic process (GO:0060544)3.18664181
101leukocyte degranulation (GO:0043299)3.17770740
102regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11539959
103negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.09397027
104regulation of erythrocyte differentiation (GO:0045646)3.06455571
105negative regulation of T-helper cell differentiation (GO:0045623)3.04957355
106negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.04957355
107activated T cell proliferation (GO:0050798)3.04935603
108protein localization to chromosome, centromeric region (GO:0071459)3.03769077
109response to type I interferon (GO:0034340)3.03211077
110type I interferon signaling pathway (GO:0060337)3.01838437
111cellular response to type I interferon (GO:0071357)3.01838437
112antigen processing and presentation via MHC class Ib (GO:0002475)3.00629658
113regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.98248751
114regulation of mast cell activation involved in immune response (GO:0033006)2.96432032
115regulation of myeloid leukocyte mediated immunity (GO:0002886)2.94757330
116hepatocyte apoptotic process (GO:0097284)2.94716432
117chromatin assembly (GO:0031497)2.94520232
118regulation of platelet aggregation (GO:0090330)2.93954128
119regulation of viral entry into host cell (GO:0046596)2.93853861
120positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.92847397
121positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.92847397
122positive regulation of mitotic sister chromatid separation (GO:1901970)2.92847397
123granulocyte differentiation (GO:0030851)2.91277243
124immunoglobulin mediated immune response (GO:0016064)2.90982893
125DNA damage response, signal transduction resulting in transcription (GO:0042772)2.90570377
126positive regulation of interferon-alpha production (GO:0032727)2.90222170
127regulation of mast cell activation (GO:0033003)2.89999983
128positive regulation of mast cell activation (GO:0033005)2.89905588
129negative regulation of adaptive immune response (GO:0002820)2.87628941
130protein localization to kinetochore (GO:0034501)2.86934278
131dendritic cell migration (GO:0036336)2.86046165
132gas transport (GO:0015669)2.85700130
133positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.84553283
134cofactor biosynthetic process (GO:0051188)2.84317183
135production of molecular mediator involved in inflammatory response (GO:0002532)2.84178219
136negative regulation of B cell mediated immunity (GO:0002713)2.84112985
137negative regulation of immunoglobulin mediated immune response (GO:0002890)2.84112985
138heme transport (GO:0015886)2.83880167
139positive regulation of chromosome segregation (GO:0051984)2.73861216
140nucleosome assembly (GO:0006334)2.63943896
141negative regulation of actin filament depolymerization (GO:0030835)2.59105433
142DNA unwinding involved in DNA replication (GO:0006268)2.58645878
143plasma lipoprotein particle organization (GO:0071827)2.57270503
144cellular response to dexamethasone stimulus (GO:0071549)2.54241005
145antibacterial humoral response (GO:0019731)2.50565743
146kinetochore organization (GO:0051383)2.49297090
147cytoskeletal anchoring at plasma membrane (GO:0007016)2.49087411
148innate immune response in mucosa (GO:0002227)2.48294016
149water-soluble vitamin biosynthetic process (GO:0042364)2.47432476
150response to dexamethasone (GO:0071548)2.47221551
151protein-lipid complex subunit organization (GO:0071825)2.43445126
152microtubule depolymerization (GO:0007019)2.42449484
153nucleosome organization (GO:0034728)2.40856763
154antimicrobial humoral response (GO:0019730)2.40128113
155hemopoiesis (GO:0030097)2.33477839
156positive regulation of gamma-delta T cell activation (GO:0046645)2.32756636
157meiotic chromosome segregation (GO:0045132)2.32386271
158regulation of histone H3-K9 methylation (GO:0051570)2.31609512
159angiogenesis involved in wound healing (GO:0060055)2.30621536
160attachment of spindle microtubules to kinetochore (GO:0008608)2.29399593
161embryonic retina morphogenesis in camera-type eye (GO:0060059)2.29144528
162ovulation from ovarian follicle (GO:0001542)2.28835907
163cysteine metabolic process (GO:0006534)2.27414674
164regulation of alpha-beta T cell proliferation (GO:0046640)2.26284744
165mitotic sister chromatid cohesion (GO:0007064)2.20237294
166chromatin assembly or disassembly (GO:0006333)2.19139553
167DNA replication initiation (GO:0006270)2.15191570
168protein autoprocessing (GO:0016540)2.14619131
169lipopolysaccharide biosynthetic process (GO:0009103)2.14237601
170DNA replication checkpoint (GO:0000076)2.14162516
171histone H3-K36 demethylation (GO:0070544)2.12611568
172RNA stabilization (GO:0043489)2.11551373
173mRNA stabilization (GO:0048255)2.11551373
174chromosome condensation (GO:0030261)2.10972468
175positive regulation of histone deacetylation (GO:0031065)2.10636271
176lipopolysaccharide metabolic process (GO:0008653)2.10509546
177purine-containing compound salvage (GO:0043101)2.10093405
178defense response to Gram-positive bacterium (GO:0050830)2.09213114
179negative regulation of actin filament polymerization (GO:0030837)2.08922100
180hyaluronan metabolic process (GO:0030212)2.08758172
181response to folic acid (GO:0051593)2.08659106
182regulation of stem cell maintenance (GO:2000036)2.07475781
183protoporphyrinogen IX metabolic process (GO:0046501)18.6774203
184protoporphyrinogen IX biosynthetic process (GO:0006782)17.3821570
185porphyrin-containing compound biosynthetic process (GO:0006779)11.9374833
186heme biosynthetic process (GO:0006783)11.2947709
187tetrapyrrole biosynthetic process (GO:0033014)10.6355266

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.07385416
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.48270454
3GATA1_22025678_ChIP-Seq_K562_Human5.15421286
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.52156307
5* GATA1_19941826_ChIP-Seq_K562_Human4.00042841
6TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.75528350
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.44172159
8SCL_19346495_ChIP-Seq_HPC-7_Human3.41194580
9GATA1_19941827_ChIP-Seq_MEL_Mouse3.39742405
10KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse3.29425912
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05236567
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.84158356
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.76604634
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.61634848
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.52509053
16* GATA2_19941826_ChIP-Seq_K562_Human2.45875360
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.44242378
18GATA1_22383799_ChIP-Seq_G1ME_Mouse2.43437701
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42302972
20MYC_22102868_ChIP-Seq_BL_Human2.36162139
21* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18203787
22VDR_21846776_ChIP-Seq_THP-1_Human2.08648383
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.08482032
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98424067
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.98423845
26GATA3_27048872_Chip-Seq_THYMUS_Human1.91982011
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.86749725
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83927793
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75481333
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72563799
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71707044
32VDR_24787735_ChIP-Seq_THP-1_Human1.68503899
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.67019031
34* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65321528
35MAF_26560356_Chip-Seq_TH1_Human1.60425879
36GATA2_22383799_ChIP-Seq_G1ME_Mouse1.56027914
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54499141
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52521838
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.51641572
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51598651
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50718237
42TCF7_22412390_ChIP-Seq_EML_Mouse1.48992711
43* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48378548
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.47030878
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46315894
46* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45561314
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43608965
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.43116578
49UTX_26944678_Chip-Seq_JUKART_Human1.42747360
50GATA3_26560356_Chip-Seq_TH2_Human1.42660832
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41766998
52* NCOR1_26117541_ChIP-Seq_K562_Human1.40454029
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39750570
54VDR_24763502_ChIP-Seq_THP-1_Human1.37940641
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37465793
56* IRF8_27001747_Chip-Seq_BMDM_Mouse1.36053014
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35722802
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35230433
59AR_21909140_ChIP-Seq_LNCAP_Human1.33954947
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33898019
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31249153
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29353877
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28351212
64* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27614556
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26603257
66KDM2B_26808549_Chip-Seq_DND41_Human1.24108495
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22147345
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22126942
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22090741
70MYB_26560356_Chip-Seq_TH2_Human1.21081427
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20001408
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18944936
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18803185
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.18358223
75* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17192458
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16071558
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15183404
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14474657
79ZNF263_19887448_ChIP-Seq_K562_Human1.14029200
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13552713
81MYB_26560356_Chip-Seq_TH1_Human1.13354237
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12906995
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12059451
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11569017
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.11086653
86* ELK3_25401928_ChIP-Seq_HUVEC_Human1.08036862
87* LXR_22158963_ChIP-Seq_LIVER_Mouse1.07932017
88FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07703261
89GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06139310
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05464567
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02361588
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01903131
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00525338
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00036034
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00028680
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99459983
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98969552
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96023354
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95450645
100FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95382849
101SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94751571
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93456568
103CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92222875
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90817787
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90049603
106SPI1_23127762_ChIP-Seq_K562_Human0.90008943
107* SMRT_27268052_Chip-Seq_Bcells_Human0.89695798
108RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89616083
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89044150
110MAF_26560356_Chip-Seq_TH2_Human0.88761316
111GATA6_25053715_ChIP-Seq_YYC3_Human0.87733150
112HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87090893
113CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86773573
114ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85969720
115TFEB_21752829_ChIP-Seq_HELA_Human0.85367376
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85279820
117SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85014494
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.84861592
119SPI1_23547873_ChIP-Seq_NB4_Human0.84410015
120RUNX_20019798_ChIP-Seq_JUKART_Human0.83278800
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81775904
122KDM5A_27292631_Chip-Seq_BREAST_Human0.79777497
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79755836
124ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78996121
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78915470
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78886755
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78737685
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78406697
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77148920
130GATA3_26560356_Chip-Seq_TH1_Human0.76357911
131CIITA_25753668_ChIP-Seq_RAJI_Human0.76065321
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75607875
133NELFA_20434984_ChIP-Seq_ESCs_Mouse0.74038870
134PU_27001747_Chip-Seq_BMDM_Mouse0.72792835
135PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71261031
136* FOXO3_23340844_ChIP-Seq_DLD1_Human0.71227783
137* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71169907
138FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.70822032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level9.13350037
2MP0003724_increased_susceptibility_to4.38381289
3MP0005083_abnormal_biliary_tract3.30601306
4MP0003111_abnormal_nucleus_morphology2.69405155
5MP0001545_abnormal_hematopoietic_system2.53390351
6MP0005397_hematopoietic_system_phenotyp2.53390351
7MP0005451_abnormal_body_composition2.50357457
8MP0000569_abnormal_digit_pigmentation2.46452737
9MP0003763_abnormal_thymus_physiology2.21499929
10MP0000685_abnormal_immune_system2.08633866
11MP0003172_abnormal_lysosome_physiology2.02170291
12MP0005464_abnormal_platelet_physiology2.01820518
13MP0004381_abnormal_hair_follicle2.00151379
14MP0003656_abnormal_erythrocyte_physiolo10.3695581
15MP0002396_abnormal_hematopoietic_system1.93666000
16MP0010094_abnormal_chromosome_stability1.91842749
17MP0002139_abnormal_hepatobiliary_system1.78108541
18MP0002398_abnormal_bone_marrow1.77825540
19MP0010307_abnormal_tumor_latency1.76729332
20MP0003077_abnormal_cell_cycle1.75050744
21MP0003303_peritoneal_inflammation1.73111621
22MP0004883_abnormal_blood_vessel1.70416967
23MP0006082_CNS_inflammation1.67038110
24MP0005636_abnormal_mineral_homeostasis1.66893560
25MP0009278_abnormal_bone_marrow1.61368581
26MP0004808_abnormal_hematopoietic_stem1.57462986
27MP0003828_pulmonary_edema1.57455050
28MP0003300_gastrointestinal_ulcer1.56315568
29MP0000689_abnormal_spleen_morphology1.54698190
30MP0002722_abnormal_immune_system1.50013534
31MP0002148_abnormal_hypersensitivity_rea1.49366833
32MP0000015_abnormal_ear_pigmentation1.48471628
33MP0005310_abnormal_salivary_gland1.44660323
34MP0001533_abnormal_skeleton_physiology1.43702863
35MP0005076_abnormal_cell_differentiation1.43549642
36MP0003866_abnormal_defecation1.39305065
37MP0005075_abnormal_melanosome_morpholog1.39203891
38MP0003221_abnormal_cardiomyocyte_apopto1.37062360
39MP0005360_urolithiasis1.36927469
40MP0008057_abnormal_DNA_replication1.35264811
41MP0002429_abnormal_blood_cell1.34842894
42MP0005164_abnormal_response_to1.28014856
43MP0005387_immune_system_phenotype1.24778845
44MP0001790_abnormal_immune_system1.24778845
45MP0000490_abnormal_crypts_of1.24084030
46MP0003705_abnormal_hypodermis_morpholog1.22471829
47MP0003787_abnormal_imprinting1.21391241
48MP0005671_abnormal_response_to1.20858942
49MP0002332_abnormal_exercise_endurance1.19795051
50MP0003693_abnormal_embryo_hatching1.17893333
51MP0005085_abnormal_gallbladder_physiolo1.17886643
52MP0009931_abnormal_skin_appearance1.14012300
53MP0001800_abnormal_humoral_immune1.13383332
54MP0004130_abnormal_muscle_cell1.13363982
55MP0010352_gastrointestinal_tract_polyps1.11559787
56MP0005025_abnormal_response_to1.11106195
57MP0002166_altered_tumor_susceptibility1.10166218
58MP0000609_abnormal_liver_physiology1.09818402
59MP0009764_decreased_sensitivity_to1.09708647
60MP0003436_decreased_susceptibility_to1.09674746
61MP0002277_abnormal_respiratory_mucosa1.09536914
62MP0005174_abnormal_tail_pigmentation1.08329350
63MP0002405_respiratory_system_inflammati1.08247330
64MP0002877_abnormal_melanocyte_morpholog1.06880142
65MP0001835_abnormal_antigen_presentation1.06668797
66MP0000350_abnormal_cell_proliferation1.04313431
67MP0004947_skin_inflammation1.03186000
68MP0001851_eye_inflammation1.03177903
69MP0000716_abnormal_immune_system1.01904114
70MP0002019_abnormal_tumor_incidence1.01323828
71MP0000703_abnormal_thymus_morphology1.00366956
72MP0003191_abnormal_cellular_cholesterol1.00183435
73MP0002452_abnormal_antigen_presenting0.99817955
74MP0005501_abnormal_skin_physiology0.99106814
75MP0008995_early_reproductive_senescence0.97222213
76MP0009333_abnormal_splenocyte_physiolog0.96252432
77MP0002419_abnormal_innate_immunity0.95317475
78MP0005000_abnormal_immune_tolerance0.94221847
79MP0002420_abnormal_adaptive_immunity0.93894638
80MP0001819_abnormal_immune_cell0.92703126
81MP0009053_abnormal_anal_canal0.92010253
82MP0009765_abnormal_xenobiotic_induced0.88686308
83MP0008770_decreased_survivor_rate0.88111353
84MP0003186_abnormal_redox_activity0.88068827
85MP0009763_increased_sensitivity_to0.88032144
86MP0000598_abnormal_liver_morphology0.87994052
87MP0000313_abnormal_cell_death0.87879914
88MP0003045_fibrosis0.85265174
89MP0006054_spinal_hemorrhage0.84625503
90MP0004484_altered_response_of0.83883239
91MP0003690_abnormal_glial_cell0.83804920
92MP0000858_altered_metastatic_potential0.83422775
93MP0002723_abnormal_immune_serum0.81220476
94MP0009785_altered_susceptibility_to0.80803711
95MP0003646_muscle_fatigue0.80433555
96MP0003566_abnormal_cell_adhesion0.79388095
97MP0010329_abnormal_lipoprotein_level0.78029499
98MP0001663_abnormal_digestive_system0.77768600
99MP0002086_abnormal_extraembryonic_tissu0.77155076
100MP0003183_abnormal_peptide_metabolism0.76793659
101MP0002006_tumorigenesis0.76416373
102MP0008775_abnormal_heart_ventricle0.76389269
103MP0004957_abnormal_blastocyst_morpholog0.75355317
104MP0001845_abnormal_inflammatory_respons0.74045788
105MP0010155_abnormal_intestine_physiology0.71314899
106MP0008872_abnormal_physiological_respon0.70012897
107MP0008469_abnormal_protein_level0.69445541
108MP0005621_abnormal_cell_physiology0.69345406
109MP0005376_homeostasis/metabolism_phenot0.69201924
110MP0005023_abnormal_wound_healing0.66920696
111MP0002998_abnormal_bone_remodeling0.66852328
112MP0004264_abnormal_extraembryonic_tissu0.66512526
113MP0008874_decreased_physiological_sensi0.65373601
114MP0003252_abnormal_bile_duct0.65357677
115MP0000465_gastrointestinal_hemorrhage0.65026825
116MP0008260_abnormal_autophagy0.63351751
117MP0002132_abnormal_respiratory_system0.62894160
118MP0009840_abnormal_foam_cell0.62727415
119MP0004510_myositis0.62315639
120MP0002095_abnormal_skin_pigmentation0.62074093
121MP0002928_abnormal_bile_duct0.61699487
122MP0001853_heart_inflammation0.61413992
123MP0000343_altered_response_to0.61319061
124MP0005365_abnormal_bile_salt0.61108323
125MP0002080_prenatal_lethality0.60569345
126MP0001730_embryonic_growth_arrest0.60469343
127MP0001191_abnormal_skin_condition0.60386301
128MP0000371_diluted_coat_color0.59441064
129MP0004197_abnormal_fetal_growth/weight/0.59420724
130MP0005319_abnormal_enzyme/_coenzyme0.59172481
131MP0006036_abnormal_mitochondrial_physio0.58972620
132MP0003984_embryonic_growth_retardation0.58531608
133MP0009643_abnormal_urine_homeostasis0.58022505
134MP0005377_hearing/vestibular/ear_phenot0.57219391
135MP0003878_abnormal_ear_physiology0.57219391
136MP0002088_abnormal_embryonic_growth/wei0.56524407
137MP0008877_abnormal_DNA_methylation0.56518214
138MP0001666_abnormal_nutrient_absorption0.55601901
139MP0001243_abnormal_dermal_layer0.55562086
140MP0005384_cellular_phenotype0.54414328
141MP0000604_amyloidosis0.53966456
142MP0000249_abnormal_blood_vessel0.49596346
143MP0003448_altered_tumor_morphology0.47649566
144MP0005266_abnormal_metabolism0.47358574

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)9.93763563
2Acanthocytosis (HP:0001927)8.94901619
3Reticulocytosis (HP:0001923)8.13939917
4Cholelithiasis (HP:0001081)6.61968800
5Abnormal gallbladder morphology (HP:0012437)5.96413171
6Paralysis (HP:0003470)5.51120175
7Diaphragmatic weakness (HP:0009113)5.46068962
8Abnormality of reticulocytes (HP:0004312)5.39693641
9Hypochromic anemia (HP:0001931)5.26395222
10Hyperbilirubinemia (HP:0002904)5.19174842
11Myositis (HP:0100614)5.00011107
12Osteomalacia (HP:0002749)4.84216437
13Orchitis (HP:0100796)4.82960108
14Optic neuritis (HP:0100653)4.71063306
15Retrobulbar optic neuritis (HP:0100654)4.71063306
16Insomnia (HP:0100785)4.45755780
17Microcytic anemia (HP:0001935)4.31436245
18Abnormality of the gallbladder (HP:0005264)4.16331755
19Stomatitis (HP:0010280)3.93918022
20Elevated erythrocyte sedimentation rate (HP:0003565)3.93855370
21Cutaneous photosensitivity (HP:0000992)3.92784920
22Abnormality of macrophages (HP:0004311)3.91626363
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.80711943
24Abnormal gallbladder physiology (HP:0012438)3.76706133
25Cholecystitis (HP:0001082)3.76706133
26Keratoconjunctivitis sicca (HP:0001097)3.74636074
27Recurrent skin infections (HP:0001581)3.66331634
28Spontaneous hematomas (HP:0007420)3.56907156
29Obstructive lung disease (HP:0006536)3.51938770
30Chronic obstructive pulmonary disease (HP:0006510)3.51938770
31Keratoconjunctivitis (HP:0001096)3.49019263
32Gingivitis (HP:0000230)3.48543573
33Polycythemia (HP:0001901)3.47414401
34Encephalitis (HP:0002383)3.34794911
35Recurrent cutaneous fungal infections (HP:0011370)3.29137716
36Chronic mucocutaneous candidiasis (HP:0002728)3.29137716
37Hepatocellular carcinoma (HP:0001402)3.24397688
38Meningitis (HP:0001287)3.24054229
39Ileus (HP:0002595)3.23480831
40Peritonitis (HP:0002586)3.23390533
41Abnormal hemoglobin (HP:0011902)3.17587700
42Leukocytosis (HP:0001974)3.09559019
43Slow saccadic eye movements (HP:0000514)3.05859987
44Pustule (HP:0200039)3.03866471
45Vasculitis (HP:0002633)3.01180962
46Urticaria (HP:0001025)2.95517825
47Arterial thrombosis (HP:0004420)2.93914547
48Chest pain (HP:0100749)2.92832565
49Abnormality of T cells (HP:0002843)2.85454173
50Anorexia (HP:0002039)2.75850866
51Abnormality of the fingertips (HP:0001211)2.61867729
52Increased serum ferritin (HP:0003281)2.59661184
53Prolonged bleeding time (HP:0003010)2.58410070
54Granulocytopenia (HP:0001913)2.58009993
55Hemoptysis (HP:0002105)2.57714081
56Petechiae (HP:0000967)2.56661769
57Toxemia of pregnancy (HP:0100603)2.56441437
58Abnormality of iron homeostasis (HP:0011031)2.54384790
59Subacute progressive viral hepatitis (HP:0006572)2.49298480
60Episodic fever (HP:0001954)2.48892220
61Inflammation of the large intestine (HP:0002037)2.48422877
62Pulmonary infiltrates (HP:0002113)2.47403057
63Pathologic fracture (HP:0002756)2.46419664
64Autoimmune thrombocytopenia (HP:0001973)2.44754675
65Renal tubular acidosis (HP:0001947)2.38666241
66Eosinophilia (HP:0001880)2.38609487
67Increased IgE level (HP:0003212)2.38426163
68Abnormal number of erythroid precursors (HP:0012131)2.37362499
69Postural instability (HP:0002172)2.36785641
70Gastrointestinal inflammation (HP:0004386)2.34244463
71Hyponatremia (HP:0002902)2.32323791
72Visual hallucinations (HP:0002367)2.31458041
73Viral hepatitis (HP:0006562)2.26511414
74Abnormality of transition element cation homeostasis (HP:0011030)2.25214098
75Nausea (HP:0002018)2.24116937
76Panhypogammaglobulinemia (HP:0003139)2.22959598
77Epistaxis (HP:0000421)2.20665010
78Pulmonary embolism (HP:0002204)2.20017556
79Abnormality of the peritoneum (HP:0002585)2.18633883
80Autoimmune hemolytic anemia (HP:0001890)2.15589479
81Abnormality of T cell physiology (HP:0011840)2.15239257
82Abnormality of sodium homeostasis (HP:0010931)2.11429527
83Nonimmune hydrops fetalis (HP:0001790)2.10054042
84Abnormal platelet volume (HP:0011876)2.08586616
85Abnormality of cells of the erythroid lineage (HP:0012130)2.06267925
86Generalized hyperpigmentation (HP:0007440)2.05945010
87Increased mean platelet volume (HP:0011877)2.04937632
88Acute hepatic failure (HP:0006554)2.03599538
89Keratitis (HP:0000491)2.02301101
90Global brain atrophy (HP:0002283)2.01231218
91Poikilocytosis (HP:0004447)12.7230263
92Abnormality of the heme biosynthetic pathway (HP:0010472)12.0987577
93Papilloma (HP:0012740)1.98400030
94Verrucae (HP:0200043)1.98400030
95Impaired platelet aggregation (HP:0003540)1.97437490
96Abnormal platelet function (HP:0011869)1.97437490
97Abnormality of eosinophils (HP:0001879)1.94880312
98Increased IgM level (HP:0003496)1.92725224
99Recurrent abscess formation (HP:0002722)1.92668355
100Recurrent bronchitis (HP:0002837)1.91795626
101Abnormality of the pleura (HP:0002103)1.91750511
102Gangrene (HP:0100758)1.89819402
103Confusion (HP:0001289)1.89372457
104Glomerulopathy (HP:0100820)1.89081526
105Lymphopenia (HP:0001888)1.87554329
106Recurrent viral infections (HP:0004429)1.87537858
107Sepsis (HP:0100806)1.85546846
108Acne (HP:0001061)1.82630562
109Onycholysis (HP:0001806)1.81472863
110Vertigo (HP:0002321)1.81362292
111Abnormality of cells of the lymphoid lineage (HP:0012140)1.80751184
112Hematochezia (HP:0002573)1.79949381
113Neoplasm of the tracheobronchial system (HP:0100552)1.79131304
114Cerebral palsy (HP:0100021)1.77676625
115Lower limb hyperreflexia (HP:0002395)1.77294200
116Short middle phalanx of the 5th finger (HP:0004220)1.76837485
117Cellulitis (HP:0100658)1.74466719
118Purpura (HP:0000979)1.73128160
119Deep venous thrombosis (HP:0002625)1.70973847
120High pitched voice (HP:0001620)1.69268790
121Basal cell carcinoma (HP:0002671)1.67381191
122Gingival bleeding (HP:0000225)1.65753953
123Birth length less than 3rd percentile (HP:0003561)1.64829697
124Joint hemorrhage (HP:0005261)1.64492563
125Recurrent bacterial skin infections (HP:0005406)1.63019946
126Eczematoid dermatitis (HP:0000976)1.63002453
127Recurrent gram-negative bacterial infections (HP:0005420)1.62203402
128Rickets (HP:0002748)1.56690267
129Hemorrhage of the eye (HP:0011885)1.56367468
130Hypertensive crisis (HP:0100735)1.53706164
131Menorrhagia (HP:0000132)1.51532522
132Hypertriglyceridemia (HP:0002155)1.50570597
133Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.47907145
134Neoplasm of the liver (HP:0002896)1.46128964
135Childhood onset (HP:0011463)1.45278308
136Thrombophlebitis (HP:0004418)1.41977666
137T lymphocytopenia (HP:0005403)1.41634110
138Broad palm (HP:0001169)1.39873431
139Cafe-au-lait spot (HP:0000957)1.39299005
140Recurrent sinusitis (HP:0011108)1.36117394
141Gastrointestinal infarctions (HP:0005244)1.35665427
142Splenomegaly (HP:0001744)1.34535319
143Recurrent fungal infections (HP:0002841)1.33866519
144Abnormal blistering of the skin (HP:0008066)1.32355356
145Macrocytic anemia (HP:0001972)1.31868845
146Prostate neoplasm (HP:0100787)1.31643797
147Abnormality of T cell number (HP:0011839)1.30747425
148Abnormality of the common coagulation pathway (HP:0010990)1.29374796
149Colitis (HP:0002583)1.28639882
150Mediastinal lymphadenopathy (HP:0100721)1.27613054
151Short 5th finger (HP:0009237)1.27601952
152Prominent nose (HP:0000448)1.27320508
153Osteomyelitis (HP:0002754)1.27186397
154Long eyelashes (HP:0000527)1.25234253
155Combined immunodeficiency (HP:0005387)1.24748420
156Long clavicles (HP:0000890)1.24726795
157IgM deficiency (HP:0002850)1.23989876
158Thin skin (HP:0000963)1.23770139
159Heterotopia (HP:0002282)1.22254100
160Poikiloderma (HP:0001029)1.20831272
161Entropion (HP:0000621)1.20680796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.60363693
2RIPK44.67424708
3CDK123.35601426
4STK43.33844170
5CDC72.90776191
6TLK12.89049909
7EEF2K2.50177605
8STK102.48011333
9FGR2.32236481
10MAP3K102.11424493
11BRSK12.06541626
12MAP4K12.05325864
13FES2.04020467
14NEK21.93777860
15ZAK1.84046619
16PRPF4B1.83588144
17PIM11.82721084
18PTK2B1.77630124
19GRK61.76553038
20TRPM71.75378636
21PKN21.71052992
22CDK61.57469633
23MAPK111.56932679
24TXK1.56894539
25TNK21.55072036
26SYK1.54537616
27EPHB11.50626234
28WNK11.49203026
29TRIB31.48865711
30MAP3K81.43776125
31MAP2K31.40499495
32CDK41.39403594
33KSR21.38133191
34MAP3K11.38098593
35BRD41.36043192
36TYK21.32473393
37ERN11.32334682
38SGK21.31010586
39TGFBR21.28340761
40MAP3K21.24818923
41STK31.23528778
42TAOK31.23207197
43NME21.22521351
44MAP3K131.22230685
45YES11.15171861
46IKBKE1.13803947
47RPS6KA51.13801682
48TAOK11.13322254
49BMPR21.12359034
50CAMK1D1.12290977
51GRK51.12109204
52AURKB1.10458575
53MARK21.09624115
54MAPKAPK31.04944533
55VRK11.04731456
56MELK1.03657286
57TEC1.03504361
58IRAK11.03091948
59PIK3CG1.01544317
60DYRK31.00644604
61JAK31.00438325
62CDK90.97667823
63MAP3K110.96115242
64MAP3K60.95690274
65KSR10.94204024
66FGFR30.94110776
67JAK20.93735746
68FLT30.93331911
69ITK0.92622419
70BRSK20.92551667
71LRRK20.88107180
72BMX0.87621082
73CLK10.86366097
74TBK10.86280932
75ERBB20.85844988
76FRK0.84306883
77MATK0.83297854
78LYN0.82364278
79SCYL20.81943640
80STK110.81639971
81RPS6KB20.80130943
82TTK0.77787801
83MAP3K70.77385800
84ATR0.77344684
85SIK20.77168824
86RAF10.76707711
87CHEK20.76302358
88IKBKB0.75222125
89IRAK20.73602894
90CHEK10.73418943
91SGK30.72994518
92MAP3K50.72816363
93HIPK20.71774268
94SGK4940.71554915
95SGK2230.71554915
96STK380.71378485
97CDC42BPA0.70752704
98MAP2K40.70126130
99ATM0.70096695
100PLK20.64675237
101KIT0.64421069
102PDK10.64059375
103ZAP700.63516024
104MAP3K140.63412604
105PRKAA10.63098301
106RPS6KA40.62561243
107NLK0.62090920
108CAMK1G0.61375729
109IRAK40.60897121
110IRAK30.60281271
111MAPKAPK20.59526146
112AURKA0.59024107
113JAK10.57750622
114SGK10.57445071
115TTN0.56475039
116CHUK0.55441505
117MARK30.55295796
118PRKD20.54221763
119SIK10.53559443
120DYRK1A0.53326092
121PRKAA20.53309071
122DYRK1B0.52309829
123BUB10.51819001
124PBK0.50799936
125NEK90.50535740
126PDPK10.49127290
127BLK0.48949740
128BTK0.48732338
129LCK0.48712654
130PLK10.48630192
131CSF1R0.48135664
132FYN0.48014933
133MAPK120.45571226
134MTOR0.45139699
135ABL20.44594149
136CSK0.44578452
137CSNK1D0.44305375
138PRKCQ0.44006290
139CDK20.43782464
140RPS6KC10.42168000
141RPS6KL10.42168000
142PTK60.41739038
143HCK0.41215450
144NEK10.41191243
145RET0.40877034
146RPS6KA60.40828719
147STK240.40362124
148MAP3K30.39720004
149TAOK20.39652097
150SIK30.35103561
151ADRBK10.34035425
152CAMKK20.33514322

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008608.08945513
2Systemic lupus erythematosus_Homo sapiens_hsa053225.00714733
3Vitamin B6 metabolism_Homo sapiens_hsa007504.21452496
4Alcoholism_Homo sapiens_hsa050342.32145552
5DNA replication_Homo sapiens_hsa030302.17917965
6Hematopoietic cell lineage_Homo sapiens_hsa046402.15996987
7Cell cycle_Homo sapiens_hsa041102.09133730
8ABC transporters_Homo sapiens_hsa020101.94918574
9Malaria_Homo sapiens_hsa051441.90436693
10Viral carcinogenesis_Homo sapiens_hsa052031.67376583
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60467490
12Chronic myeloid leukemia_Homo sapiens_hsa052201.52184841
13Graft-versus-host disease_Homo sapiens_hsa053321.51964163
14African trypanosomiasis_Homo sapiens_hsa051431.46827461
15Allograft rejection_Homo sapiens_hsa053301.38241931
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37303193
17Leishmaniasis_Homo sapiens_hsa051401.36713127
18Staphylococcus aureus infection_Homo sapiens_hsa051501.36435581
19Non-small cell lung cancer_Homo sapiens_hsa052231.35677542
20Herpes simplex infection_Homo sapiens_hsa051681.35069746
21One carbon pool by folate_Homo sapiens_hsa006701.32717436
22Autoimmune thyroid disease_Homo sapiens_hsa053201.29848596
23Complement and coagulation cascades_Homo sapiens_hsa046101.29461854
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28881751
25Small cell lung cancer_Homo sapiens_hsa052221.21875619
26B cell receptor signaling pathway_Homo sapiens_hsa046621.21198961
27Bladder cancer_Homo sapiens_hsa052191.20811402
28Prolactin signaling pathway_Homo sapiens_hsa049171.19855283
29Apoptosis_Homo sapiens_hsa042101.19852939
30VEGF signaling pathway_Homo sapiens_hsa043701.16054824
31Measles_Homo sapiens_hsa051621.15711769
32Caffeine metabolism_Homo sapiens_hsa002321.12181232
33Lysine degradation_Homo sapiens_hsa003101.11618456
34Renal cell carcinoma_Homo sapiens_hsa052111.11550486
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10965727
36Nitrogen metabolism_Homo sapiens_hsa009101.10446848
37Selenocompound metabolism_Homo sapiens_hsa004501.10210614
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.09407408
39Sulfur relay system_Homo sapiens_hsa041221.08452469
40Endometrial cancer_Homo sapiens_hsa052131.07303150
41Hepatitis B_Homo sapiens_hsa051611.04470736
42Pancreatic cancer_Homo sapiens_hsa052121.00573473
43Osteoclast differentiation_Homo sapiens_hsa043800.99941307
44Phagosome_Homo sapiens_hsa041450.99453910
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99339804
46p53 signaling pathway_Homo sapiens_hsa041150.98335551
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94284098
48Influenza A_Homo sapiens_hsa051640.93663930
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93427712
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.92627782
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90189179
52Inositol phosphate metabolism_Homo sapiens_hsa005620.89147214
53Primary immunodeficiency_Homo sapiens_hsa053400.88687982
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88408647
55Base excision repair_Homo sapiens_hsa034100.88182159
56Type I diabetes mellitus_Homo sapiens_hsa049400.87690445
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87604511
58Regulation of autophagy_Homo sapiens_hsa041400.83297235
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82565998
60Antigen processing and presentation_Homo sapiens_hsa046120.79060902
61Type II diabetes mellitus_Homo sapiens_hsa049300.78799641
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.78154129
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77941529
64Choline metabolism in cancer_Homo sapiens_hsa052310.77705651
65Notch signaling pathway_Homo sapiens_hsa043300.77056338
66Viral myocarditis_Homo sapiens_hsa054160.76068341
67Mismatch repair_Homo sapiens_hsa034300.75584480
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74335806
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71790976
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69902102
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69647013
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68261310
73Shigellosis_Homo sapiens_hsa051310.67505009
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66287647
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.66261475
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.65341541
77Fanconi anemia pathway_Homo sapiens_hsa034600.65239772
78Platelet activation_Homo sapiens_hsa046110.65214657
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.65189846
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65185415
81Prostate cancer_Homo sapiens_hsa052150.64666709
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64337367
83MicroRNAs in cancer_Homo sapiens_hsa052060.64222814
84Toxoplasmosis_Homo sapiens_hsa051450.63922886
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62826980
86Glutathione metabolism_Homo sapiens_hsa004800.62785776
87Endocytosis_Homo sapiens_hsa041440.62629486
88Hepatitis C_Homo sapiens_hsa051600.62401438
89ErbB signaling pathway_Homo sapiens_hsa040120.62350625
90HTLV-I infection_Homo sapiens_hsa051660.62152933
91Acute myeloid leukemia_Homo sapiens_hsa052210.61280984
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59915841
93FoxO signaling pathway_Homo sapiens_hsa040680.58173000
94GnRH signaling pathway_Homo sapiens_hsa049120.57304375
95Homologous recombination_Homo sapiens_hsa034400.57225449
96Glioma_Homo sapiens_hsa052140.56457025
97Nucleotide excision repair_Homo sapiens_hsa034200.55806638
98Colorectal cancer_Homo sapiens_hsa052100.54295580
99MAPK signaling pathway_Homo sapiens_hsa040100.54025379
100Salmonella infection_Homo sapiens_hsa051320.53015035
101Insulin resistance_Homo sapiens_hsa049310.52465433
102Collecting duct acid secretion_Homo sapiens_hsa049660.52064767
103Tuberculosis_Homo sapiens_hsa051520.51920012
104TNF signaling pathway_Homo sapiens_hsa046680.51727694
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.51187576
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.50370553
107Dorso-ventral axis formation_Homo sapiens_hsa043200.48923814
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48841435
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47931231
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47104790
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.45040640
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44199605
113Long-term potentiation_Homo sapiens_hsa047200.43638902
114Tryptophan metabolism_Homo sapiens_hsa003800.43210096
115Legionellosis_Homo sapiens_hsa051340.43153339
116Non-homologous end-joining_Homo sapiens_hsa034500.42833658
117Arginine biosynthesis_Homo sapiens_hsa002200.42493680
118Chemokine signaling pathway_Homo sapiens_hsa040620.42259114
119Pertussis_Homo sapiens_hsa051330.40852267
120mRNA surveillance pathway_Homo sapiens_hsa030150.40339927
121Rap1 signaling pathway_Homo sapiens_hsa040150.40071607
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.39619768
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38552524
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37811373
125T cell receptor signaling pathway_Homo sapiens_hsa046600.36388576
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36192170
127Epstein-Barr virus infection_Homo sapiens_hsa051690.35928694
128Bile secretion_Homo sapiens_hsa049760.35139237
129AMPK signaling pathway_Homo sapiens_hsa041520.34909919
130Pentose phosphate pathway_Homo sapiens_hsa000300.33894169
131Thyroid cancer_Homo sapiens_hsa052160.32141371
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.31695206
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31331375
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29855640
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28187568
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27168530
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26991837
138PPAR signaling pathway_Homo sapiens_hsa033200.26633025
139mTOR signaling pathway_Homo sapiens_hsa041500.23823337
140Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22907745
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.22792855
142HIF-1 signaling pathway_Homo sapiens_hsa040660.22356487
143Melanoma_Homo sapiens_hsa052180.22348394
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.22338893

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