SLC25A38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the mitochondrial carrier family. The encoded protein is required during erythropoiesis and is important for the biosynthesis of heme. Mutations in this gene are the cause of autosomal congenital sideroblastic anemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.57422978
2central nervous system myelination (GO:0022010)9.57422978
3fatty acid elongation (GO:0030497)8.16463023
4ensheathment of neurons (GO:0007272)6.15102083
5axon ensheathment (GO:0008366)6.15102083
6myelination (GO:0042552)6.12936073
7protoporphyrinogen IX metabolic process (GO:0046501)5.92009922
8protoporphyrinogen IX biosynthetic process (GO:0006782)5.80527276
9cholesterol biosynthetic process (GO:0006695)5.77852825
10sterol biosynthetic process (GO:0016126)5.03359320
11long-chain fatty acid biosynthetic process (GO:0042759)4.89647121
12glycerophospholipid catabolic process (GO:0046475)4.89549806
13myelin maintenance (GO:0043217)4.57231695
14response to methylmercury (GO:0051597)4.53562269
15isoprenoid biosynthetic process (GO:0008299)4.50790312
16establishment of mitochondrion localization (GO:0051654)4.34956579
17creatine metabolic process (GO:0006600)4.22461143
18ribosomal small subunit assembly (GO:0000028)4.19515114
19heme transport (GO:0015886)4.15767373
20* heme biosynthetic process (GO:0006783)4.14860746
21long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.13491466
22negative regulation of neurotransmitter secretion (GO:0046929)4.07560298
23ribosomal large subunit biogenesis (GO:0042273)4.04922274
24L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.02082927
25peptidyl-cysteine modification (GO:0018198)3.89557393
26L-phenylalanine catabolic process (GO:0006559)3.87823928
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.87823928
28fatty-acyl-CoA biosynthetic process (GO:0046949)3.87249789
29* porphyrin-containing compound biosynthetic process (GO:0006779)3.81185010
30pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.76525575
31* heme metabolic process (GO:0042168)3.74829758
32adhesion of symbiont to host cell (GO:0044650)3.74091995
33virion attachment to host cell (GO:0019062)3.74091995
34activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.72119038
35GPI anchor biosynthetic process (GO:0006506)3.70446187
36amino acid salvage (GO:0043102)3.68787954
37L-methionine salvage (GO:0071267)3.68787954
38L-methionine biosynthetic process (GO:0071265)3.68787954
39response to lead ion (GO:0010288)3.68233258
40amyloid precursor protein metabolic process (GO:0042982)3.65686054
41long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.65404719
42formation of translation preinitiation complex (GO:0001731)3.63245338
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.61726072
44L-phenylalanine metabolic process (GO:0006558)3.61726072
45proteasome assembly (GO:0043248)3.61227937
46rRNA modification (GO:0000154)3.58351868
47substantia nigra development (GO:0021762)3.55599638
48L-serine metabolic process (GO:0006563)3.55435607
49ribonucleoprotein complex biogenesis (GO:0022613)3.55373856
50ribosome biogenesis (GO:0042254)3.55246438
51fatty-acyl-CoA metabolic process (GO:0035337)3.54063576
52oligodendrocyte differentiation (GO:0048709)3.53173047
53preassembly of GPI anchor in ER membrane (GO:0016254)3.49388384
54GPI anchor metabolic process (GO:0006505)3.46874499
55positive regulation of cellular amine metabolic process (GO:0033240)3.44368053
56establishment of integrated proviral latency (GO:0075713)3.43564947
57* tetrapyrrole biosynthetic process (GO:0033014)3.41783526
58regulation of collateral sprouting (GO:0048670)3.40218334
59* porphyrin-containing compound metabolic process (GO:0006778)3.39283108
60iron coordination entity transport (GO:1901678)3.38166174
61negative regulation of neurotransmitter transport (GO:0051589)3.36193236
62very long-chain fatty acid metabolic process (GO:0000038)3.36123307
63ribosomal small subunit biogenesis (GO:0042274)3.35735837
64regulation of mitochondrial translation (GO:0070129)3.35079929
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.33556658
66apical protein localization (GO:0045176)3.32008910
67ribosome assembly (GO:0042255)3.30925457
68acyl-CoA biosynthetic process (GO:0071616)3.30644275
69thioester biosynthetic process (GO:0035384)3.30644275
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29530309
71maturation of SSU-rRNA (GO:0030490)3.28822918
72DNA ligation (GO:0006266)3.27630653
73DNA strand elongation involved in DNA replication (GO:0006271)3.26166037
74pyrimidine nucleotide catabolic process (GO:0006244)3.25829859
75nuclear envelope reassembly (GO:0031468)3.25208672
76mitotic nuclear envelope reassembly (GO:0007084)3.25208672
77viral transcription (GO:0019083)3.22092465
78asymmetric protein localization (GO:0008105)3.22005825
79negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.20580947
80membrane tubulation (GO:0097320)3.18882787
81response to redox state (GO:0051775)3.18222127
82chaperone-mediated protein transport (GO:0072321)3.18160928
83DNA strand elongation (GO:0022616)3.17203233
84protein neddylation (GO:0045116)3.16782572
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15306159
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14300770
87astrocyte development (GO:0014002)3.12876650
88telomere maintenance via semi-conservative replication (GO:0032201)3.12280869
89translational termination (GO:0006415)3.09444376
90translational elongation (GO:0006414)3.05312734
91pseudouridine synthesis (GO:0001522)3.04019923
92serine family amino acid biosynthetic process (GO:0009070)3.03229658
93axon development (GO:0061564)3.02905356
94histone H2B ubiquitination (GO:0033523)3.02692357
95termination of RNA polymerase III transcription (GO:0006386)3.01960890
96transcription elongation from RNA polymerase III promoter (GO:0006385)3.01960890
97SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.00086339
98import into cell (GO:0098657)2.98827042
99establishment of viral latency (GO:0019043)2.98689869
100ribonucleoprotein complex disassembly (GO:0032988)2.97933734
101negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.95980143
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95640816
103microtubule polymerization or depolymerization (GO:0031109)2.94571479
104glutathione biosynthetic process (GO:0006750)2.94356120
105transcription from mitochondrial promoter (GO:0006390)2.94238962
106respiratory electron transport chain (GO:0022904)2.94191135
107protein palmitoylation (GO:0018345)2.92995927
108base-excision repair (GO:0006284)2.92915171
109nucleotide transmembrane transport (GO:1901679)2.92722964
110ATP synthesis coupled proton transport (GO:0015986)2.91382151
111energy coupled proton transport, down electrochemical gradient (GO:0015985)2.91382151
112translational initiation (GO:0006413)2.90736109
113adhesion of symbiont to host (GO:0044406)2.90313641
114metallo-sulfur cluster assembly (GO:0031163)2.90219156
115iron-sulfur cluster assembly (GO:0016226)2.90219156
116positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90057961
117protein targeting to ER (GO:0045047)2.89506330
118GDP-mannose metabolic process (GO:0019673)2.89107758
119cotranslational protein targeting to membrane (GO:0006613)2.88832291
120positive regulation of action potential (GO:0045760)2.88602306
121cysteine metabolic process (GO:0006534)2.88427233
122pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88048113
123negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.86862156
124negative regulation of ligase activity (GO:0051352)2.86666263
125negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86666263
126acetyl-CoA metabolic process (GO:0006084)2.86476715
127rRNA methylation (GO:0031167)2.85789934
128amyloid precursor protein catabolic process (GO:0042987)2.85429270
129nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85101482
130pyrimidine-containing compound transmembrane transport (GO:0072531)2.85060793
131cellular component biogenesis (GO:0044085)2.84130618
132electron transport chain (GO:0022900)2.84122195
133anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82901605
134sphingosine metabolic process (GO:0006670)2.82114253
135rRNA transcription (GO:0009303)2.81423572
136eye photoreceptor cell differentiation (GO:0001754)2.80719052
137photoreceptor cell differentiation (GO:0046530)2.80719052
138deoxyribonucleotide catabolic process (GO:0009264)2.80067595
139deoxyribose phosphate catabolic process (GO:0046386)2.79653176
140leukocyte migration involved in inflammatory response (GO:0002523)2.78935807
141protein localization to endoplasmic reticulum (GO:0070972)2.78811141
142DNA topological change (GO:0006265)2.77306890
143acyl-CoA metabolic process (GO:0006637)2.77212997
144thioester metabolic process (GO:0035383)2.77212997
145regulation of lipoprotein metabolic process (GO:0050746)2.76663635
146proline biosynthetic process (GO:0006561)2.76209606
147establishment of protein localization to endoplasmic reticulum (GO:0072599)2.75599892
148pentose-phosphate shunt (GO:0006098)2.75550714
149positive regulation of oligodendrocyte differentiation (GO:0048714)2.75457709
150regulation of cellular amino acid metabolic process (GO:0006521)2.75360377
151glycosylceramide metabolic process (GO:0006677)2.75351207
152translation (GO:0006412)2.75319924
153glutathione derivative biosynthetic process (GO:1901687)2.75075082
154glutathione derivative metabolic process (GO:1901685)2.75075082
155rRNA processing (GO:0006364)2.73146624
156protein targeting to mitochondrion (GO:0006626)2.72556160
157valine metabolic process (GO:0006573)2.72447262
158DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72366249
159negative regulation of cell size (GO:0045792)2.72329042
160NADPH regeneration (GO:0006740)2.71853441
161negative regulation of acute inflammatory response (GO:0002674)2.71027444
162spliceosomal snRNP assembly (GO:0000387)2.70220208
163signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.68719900
164signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.68719900
165signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.68719900
166intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68476464
167signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68476464
168signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66397225
169signal transduction involved in DNA damage checkpoint (GO:0072422)2.66397225
170glycine metabolic process (GO:0006544)2.65770239
171tRNA aminoacylation for protein translation (GO:0006418)2.65537420
172negative regulation of mRNA processing (GO:0050686)2.65283215
173regulation of helicase activity (GO:0051095)2.63796258
174positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.63765829
175viral life cycle (GO:0019058)2.63535556
176rRNA metabolic process (GO:0016072)2.61047506
177peptidyl-arginine omega-N-methylation (GO:0035247)2.59445428
178folic acid metabolic process (GO:0046655)2.58770014
179negative regulation of RNA splicing (GO:0033119)2.58136487
180signal transduction involved in cell cycle checkpoint (GO:0072395)2.57575847
181positive regulation of ligase activity (GO:0051351)2.57427191
182tRNA aminoacylation (GO:0043039)2.55718043
183amino acid activation (GO:0043038)2.55718043
184telomere maintenance via recombination (GO:0000722)2.54012958
185histone H2A acetylation (GO:0043968)2.53026529
186mitochondrial DNA metabolic process (GO:0032042)2.53016130
187regulation of translational fidelity (GO:0006450)2.52400460
188regulation of translation in response to stress (GO:0043555)2.52377076
189folic acid-containing compound biosynthetic process (GO:0009396)2.51710858
190telomere maintenance via telomere lengthening (GO:0010833)2.50887213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.46995141
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.06093964
3E2F7_22180533_ChIP-Seq_HELA_Human4.38552279
4CREB1_15753290_ChIP-ChIP_HEK293T_Human3.95738962
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.87233409
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.61017565
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.49534570
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.42412795
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23521776
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.17480498
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.16476545
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.15359857
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.95566543
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.69035476
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52485946
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47192682
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26265136
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.17672996
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10550389
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10368459
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03815186
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.00670121
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.95620107
24* MYC_22102868_ChIP-Seq_BL_Human1.94473592
25GATA1_22025678_ChIP-Seq_K562_Human1.91769271
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90786293
27ZFX_18555785_ChIP-Seq_MESCs_Mouse1.87885218
28VDR_23849224_ChIP-Seq_CD4+_Human1.75117101
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74008950
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.69785070
31TTF2_22483619_ChIP-Seq_HELA_Human1.67336494
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65055384
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.63945933
34STAT1_20625510_ChIP-Seq_HELA_Human1.57598305
35XRN2_22483619_ChIP-Seq_HELA_Human1.57230870
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.56637567
37* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56294455
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56252127
39GATA1_19941826_ChIP-Seq_K562_Human1.56243403
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.56148565
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54928200
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.54135177
43IRF1_19129219_ChIP-ChIP_H3396_Human1.54063553
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50616942
45CIITA_25753668_ChIP-Seq_RAJI_Human1.47848871
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46761421
47DCP1A_22483619_ChIP-Seq_HELA_Human1.46326945
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40942167
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40847555
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39722662
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39003289
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37348075
53* CTCF_20526341_ChIP-Seq_ESCs_Human1.35580091
54EOMES_21245162_ChIP-Seq_HESCs_Human1.35139058
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34475783
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33833189
57GABP_19822575_ChIP-Seq_HepG2_Human1.33711335
58* TFEB_21752829_ChIP-Seq_HELA_Human1.33190120
59VDR_21846776_ChIP-Seq_THP-1_Human1.31985585
60* YY1_22570637_ChIP-Seq_MALME-3M_Human1.29766796
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29255504
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29217996
63SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.27829017
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26935777
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.26074652
66SOX17_20123909_ChIP-Seq_XEN_Mouse1.25285104
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.25066672
68* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24938088
69NANOG_20526341_ChIP-Seq_ESCs_Human1.23503856
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21695751
71FOXP3_21729870_ChIP-Seq_TREG_Human1.21154198
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.21126084
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18659608
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18542403
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17656756
76LXR_22158963_ChIP-Seq_LIVER_Mouse1.16992459
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15880098
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11019897
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10624588
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09996192
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08940188
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08439506
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08344501
84* GATA1_19941827_ChIP-Seq_MEL_Mouse1.07816475
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07500037
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07315140
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06886081
88AR_21909140_ChIP-Seq_LNCAP_Human1.04702426
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03839571
90ZNF263_19887448_ChIP-Seq_K562_Human1.01558375
91ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99837193
92SPI1_23547873_ChIP-Seq_NB4_Human0.99626181
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99612486
94UTX_26944678_Chip-Seq_JUKART_Human0.98766867
95TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98749439
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98432952
97NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97143608
98* BCOR_27268052_Chip-Seq_Bcells_Human0.96704981
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95409753
100MAF_26560356_Chip-Seq_TH1_Human0.95116884
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.95026153
102HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94941496
103* OCT4_20526341_ChIP-Seq_ESCs_Human0.94461737
104GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93779678
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93764650
106FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93104977
107MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92866999
108TAF15_26573619_Chip-Seq_HEK293_Human0.92415369
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90590591
110MAF_26560356_Chip-Seq_TH2_Human0.90274356
111* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90007702
112CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89705826
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89618139
114KDM5A_27292631_Chip-Seq_BREAST_Human0.88957402
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88672182
116P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.87169604
117* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87006779
118KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86643309
119MYC_18940864_ChIP-ChIP_HL60_Human0.86420770
120* TET1_21451524_ChIP-Seq_MESCs_Mouse0.86296529
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86180635
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85654258
123* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85475157
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84622327
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.83694663
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83439360
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83439360
128VDR_22108803_ChIP-Seq_LS180_Human0.83149952
129FOXP1_21924763_ChIP-Seq_HESCs_Human0.80286676
130GATA1_26923725_Chip-Seq_HPCs_Mouse0.80032386
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77931694
132* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77645338
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.76478607
134SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76262983
135ELK1_19687146_ChIP-ChIP_HELA_Human0.76003066
136EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.75954451
137TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.74875257
138SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74689098
139* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74491351
140SA1_27219007_Chip-Seq_Bcells_Human0.73307116
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73256349
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.73120408
143SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72106639
144NCOR_22424771_ChIP-Seq_293T_Human0.71953889

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.21996878
2MP0004147_increased_porphyrin_level5.11196403
3MP0000920_abnormal_myelination5.05366222
4MP0003656_abnormal_erythrocyte_physiolo5.03296419
5MP0005451_abnormal_body_composition4.07861914
6MP0008058_abnormal_DNA_repair3.66524687
7MP0003111_abnormal_nucleus_morphology3.63128853
8MP0003693_abnormal_embryo_hatching3.53601508
9MP0003950_abnormal_plasma_membrane3.13414365
10MP0001529_abnormal_vocalization2.97890306
11MP0003329_amyloid_beta_deposits2.95266810
12MP0003077_abnormal_cell_cycle2.77764907
13MP0001905_abnormal_dopamine_level2.58492538
14MP0003786_premature_aging2.57033037
15MP0010094_abnormal_chromosome_stability2.52864052
16MP0003763_abnormal_thymus_physiology2.41996816
17MP0002139_abnormal_hepatobiliary_system2.31636011
18MP0009840_abnormal_foam_cell2.19786869
19MP0003690_abnormal_glial_cell2.14031384
20MP0003718_maternal_effect2.11228147
21MP0004270_analgesia2.04565256
22MP0009697_abnormal_copulation2.01396575
23MP0002396_abnormal_hematopoietic_system1.99692126
24MP0004142_abnormal_muscle_tone1.99262982
25MP0008007_abnormal_cellular_replicative1.93166468
26MP0008260_abnormal_autophagy1.88230692
27MP0005360_urolithiasis1.82476795
28MP0000604_amyloidosis1.78385547
29MP0004381_abnormal_hair_follicle1.76575560
30MP0005083_abnormal_biliary_tract1.74788562
31MP0001545_abnormal_hematopoietic_system1.74505934
32MP0005397_hematopoietic_system_phenotyp1.74505934
33MP0005410_abnormal_fertilization1.73766121
34MP0008875_abnormal_xenobiotic_pharmacok1.72457894
35MP0002229_neurodegeneration1.72256269
36MP0001485_abnormal_pinna_reflex1.72171590
37MP0000350_abnormal_cell_proliferation1.70664544
38MP0003634_abnormal_glial_cell1.69732276
39MP0003136_yellow_coat_color1.67523171
40MP0003632_abnormal_nervous_system1.66589737
41MP0004885_abnormal_endolymph1.64961906
42MP0000313_abnormal_cell_death1.58131087
43MP0008057_abnormal_DNA_replication1.57529311
44MP0001873_stomach_inflammation1.52675694
45MP0000703_abnormal_thymus_morphology1.52401726
46MP0003186_abnormal_redox_activity1.50302523
47MP0006036_abnormal_mitochondrial_physio1.50239428
48MP0001764_abnormal_homeostasis1.48517889
49MP0005408_hypopigmentation1.46401911
50MP0002398_abnormal_bone_marrow1.45708072
51MP0001853_heart_inflammation1.45110934
52MP0004043_abnormal_pH_regulation1.44394027
53MP0008995_early_reproductive_senescence1.43094650
54MP0001661_extended_life_span1.42650479
55MP0003880_abnormal_central_pattern1.42520403
56MP0005332_abnormal_amino_acid1.42366948
57MP0002272_abnormal_nervous_system1.40166075
58MP0000490_abnormal_crypts_of1.38839889
59MP0004742_abnormal_vestibular_system1.38781826
60MP0002722_abnormal_immune_system1.36827251
61MP0000689_abnormal_spleen_morphology1.35354787
62MP0003195_calcinosis1.33377285
63MP0002019_abnormal_tumor_incidence1.33054703
64MP0002080_prenatal_lethality1.31914270
65MP0004185_abnormal_adipocyte_glucose1.31845083
66MP0005085_abnormal_gallbladder_physiolo1.30604683
67MP0000747_muscle_weakness1.27961992
68MP0006082_CNS_inflammation1.27436623
69MP0009278_abnormal_bone_marrow1.27007893
70MP0001697_abnormal_embryo_size1.19934693
71MP0008932_abnormal_embryonic_tissue1.17668989
72MP0009672_abnormal_birth_weight1.12614310
73MP0005501_abnormal_skin_physiology1.12161758
74MP0000358_abnormal_cell_content/1.11435727
75MP0002429_abnormal_blood_cell1.10578055
76MP0001672_abnormal_embryogenesis/_devel1.10519825
77MP0005380_embryogenesis_phenotype1.10519825
78MP0001348_abnormal_lacrimal_gland1.08040732
79MP0000751_myopathy1.05959258
80MP0004808_abnormal_hematopoietic_stem1.05359329
81MP0005636_abnormal_mineral_homeostasis1.01753900
82MP0004782_abnormal_surfactant_physiolog1.01393961
83MP0005330_cardiomyopathy1.01370898
84MP0004233_abnormal_muscle_weight1.00041720
85MP0002653_abnormal_ependyma_morphology0.99755557
86MP0000465_gastrointestinal_hemorrhage0.99353110
87MP0000678_abnormal_parathyroid_gland0.98979276
88MP0001346_abnormal_lacrimal_gland0.98387982
89MP0001881_abnormal_mammary_gland0.97694523
90MP0008961_abnormal_basal_metabolism0.97350719
91MP0003984_embryonic_growth_retardation0.96497750
92MP0002163_abnormal_gland_morphology0.96434927
93MP0005409_darkened_coat_color0.95739124
94MP0002822_catalepsy0.94467149
95MP0000716_abnormal_immune_system0.92442605
96MP0002088_abnormal_embryonic_growth/wei0.91182937
97MP0009333_abnormal_splenocyte_physiolog0.91084559
98MP0005584_abnormal_enzyme/coenzyme_acti0.91031912
99MP0001486_abnormal_startle_reflex0.90774276
100MP0005365_abnormal_bile_salt0.90232458
101MP0000462_abnormal_digestive_system0.89864684
102MP0003011_delayed_dark_adaptation0.89493429
103MP0005464_abnormal_platelet_physiology0.89465367
104MP0000598_abnormal_liver_morphology0.88646041
105MP0001851_eye_inflammation0.88574719
106MP0005319_abnormal_enzyme/_coenzyme0.88546262
107MP0002118_abnormal_lipid_homeostasis0.83753314
108MP0009765_abnormal_xenobiotic_induced0.83632087
109MP0008789_abnormal_olfactory_epithelium0.82988153
110MP0005621_abnormal_cell_physiology0.82977248
111MP0003937_abnormal_limbs/digits/tail_de0.82868161
112MP0005384_cellular_phenotype0.82489527
113MP0002420_abnormal_adaptive_immunity0.81305861
114MP0002734_abnormal_mechanical_nocicepti0.80675064
115MP0000613_abnormal_salivary_gland0.80417312
116MP0001819_abnormal_immune_cell0.80330843
117MP0002086_abnormal_extraembryonic_tissu0.79818730
118MP0001727_abnormal_embryo_implantation0.79794291
119MP0002102_abnormal_ear_morphology0.79427702
120MP0001986_abnormal_taste_sensitivity0.79212549
121MP0000955_abnormal_spinal_cord0.78916681
122MP0003938_abnormal_ear_development0.77312301
123MP0002405_respiratory_system_inflammati0.76938274
124MP0002269_muscular_atrophy0.76654120
125MP0003631_nervous_system_phenotype0.76505993
126MP0009785_altered_susceptibility_to0.76066480
127MP0003436_decreased_susceptibility_to0.75606103
128MP0001849_ear_inflammation0.74958817
129MP0003221_abnormal_cardiomyocyte_apopto0.74262807
130MP0002085_abnormal_embryonic_tissue0.74201408
131MP0002752_abnormal_somatic_nervous0.74177822
132MP0000749_muscle_degeneration0.72420389
133MP0001730_embryonic_growth_arrest0.71067001
134MP0002066_abnormal_motor_capabilities/c0.70994111
135MP0000383_abnormal_hair_follicle0.70837850
136MP0005379_endocrine/exocrine_gland_phen0.70763092
137MP0005075_abnormal_melanosome_morpholog0.70181321
138MP0002084_abnormal_developmental_patter0.68725163
139MP0005000_abnormal_immune_tolerance0.68600020
140MP0002138_abnormal_hepatobiliary_system0.67980783
141MP0000778_abnormal_nervous_system0.67276761
142MP0002064_seizures0.66656022
143MP0005058_abnormal_lysosome_morphology0.66194245
144MP0000750_abnormal_muscle_regeneration0.65538981
145MP0005171_absent_coat_pigmentation0.65126612
146MP0001800_abnormal_humoral_immune0.64142838
147MP0001666_abnormal_nutrient_absorption0.63733191
148MP0002882_abnormal_neuron_morphology0.63503941
149MP0010678_abnormal_skin_adnexa0.63405936
150MP0001963_abnormal_hearing_physiology0.63165061
151MP0006035_abnormal_mitochondrial_morpho0.61202895
152MP0001243_abnormal_dermal_layer0.60769797
153MP0009046_muscle_twitch0.60414870
154MP0005195_abnormal_posterior_eye0.60189674
155MP0000579_abnormal_nail_morphology0.59618966
156MP0000685_abnormal_immune_system0.58962188
157MP0000467_abnormal_esophagus_morphology0.57552058
158MP0001970_abnormal_pain_threshold0.57005843
159MP0004924_abnormal_behavior0.56093314
160MP0005386_behavior/neurological_phenoty0.56093314
161MP0000372_irregular_coat_pigmentation0.55620577
162MP0000609_abnormal_liver_physiology0.54775816
163MP0005395_other_phenotype0.53520508
164MP0005266_abnormal_metabolism0.53383452
165MP0002132_abnormal_respiratory_system0.51593905
166MP0003191_abnormal_cellular_cholesterol0.51442503
167MP0009643_abnormal_urine_homeostasis0.51279351
168MP0004957_abnormal_blastocyst_morpholog0.50516654

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.77897295
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.77897295
3Abnormality of the heme biosynthetic pathway (HP:0010472)5.22794774
4Abnormality of glycolysis (HP:0004366)5.18864300
5Increased serum pyruvate (HP:0003542)5.18864300
6Neurofibrillary tangles (HP:0002185)4.99998982
7Microvesicular hepatic steatosis (HP:0001414)4.98589433
8Parakeratosis (HP:0001036)4.85679889
9Cerebral hypomyelination (HP:0006808)4.82648436
10Sensory axonal neuropathy (HP:0003390)4.77776864
11Abnormality of the corticospinal tract (HP:0002492)4.32011424
12Exercise-induced myalgia (HP:0003738)4.23873393
13Exercise-induced muscle cramps (HP:0003710)3.86153758
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.77800882
15Cerebral inclusion bodies (HP:0100314)3.54920649
16Spastic paraparesis (HP:0002313)3.53039886
17Peripheral hypomyelination (HP:0007182)3.51033619
18Muscle stiffness (HP:0003552)3.35254202
19Aplastic anemia (HP:0001915)3.31513269
20Acanthocytosis (HP:0001927)3.27139499
21Calf muscle hypertrophy (HP:0008981)3.26487141
22Reduced antithrombin III activity (HP:0001976)3.17016209
23Cerebral hemorrhage (HP:0001342)3.16797210
24Abnormality of aromatic amino acid family metabolism (HP:0004338)3.15857581
25Paralysis (HP:0003470)3.15302268
263-Methylglutaconic aciduria (HP:0003535)3.15193188
27Leukodystrophy (HP:0002415)3.12549307
28Muscle hypertrophy of the lower extremities (HP:0008968)3.11765284
29Poikilocytosis (HP:0004447)3.11217581
30Cholecystitis (HP:0001082)3.06771857
31Abnormal gallbladder physiology (HP:0012438)3.06771857
32Acute necrotizing encephalopathy (HP:0006965)3.02729298
33Hepatocellular necrosis (HP:0001404)3.02637592
34Ragged-red muscle fibers (HP:0003200)2.96341361
35Posterior subcapsular cataract (HP:0007787)2.95523270
36Congenital ichthyosiform erythroderma (HP:0007431)2.90805971
37Acute encephalopathy (HP:0006846)2.85089441
38Rough bone trabeculation (HP:0100670)2.83422942
39Ileus (HP:0002595)2.83306334
40Progressive external ophthalmoplegia (HP:0000590)2.82303303
41Mitochondrial inheritance (HP:0001427)2.80407301
42Spastic gait (HP:0002064)2.78362265
43Renal Fanconi syndrome (HP:0001994)2.76254769
44CNS hypomyelination (HP:0003429)2.74623432
45Onion bulb formation (HP:0003383)2.73528204
46Intrahepatic cholestasis (HP:0001406)2.71942714
47Hypoplastic pelvis (HP:0008839)2.67449056
48Abnormal gallbladder morphology (HP:0012437)2.66603127
49Brushfield spots (HP:0001088)2.65731786
50Premature ovarian failure (HP:0008209)2.64402419
51Delusions (HP:0000746)2.61949322
52Multiple enchondromatosis (HP:0005701)2.57514017
53Type I transferrin isoform profile (HP:0003642)2.55092062
54Abnormal mitochondria in muscle tissue (HP:0008316)2.54895578
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.54695501
56Abnormal auditory evoked potentials (HP:0006958)2.53856073
57Abnormality of the left ventricular outflow tract (HP:0011103)2.52892446
58Subaortic stenosis (HP:0001682)2.52892446
59Progressive muscle weakness (HP:0003323)2.51745320
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51401324
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51401324
62Hepatic necrosis (HP:0002605)2.50294117
63Hypoglycemic seizures (HP:0002173)2.48912333
64Cholelithiasis (HP:0001081)2.48576685
65Increased hepatocellular lipid droplets (HP:0006565)2.42207077
66Abnormality of reticulocytes (HP:0004312)2.42088247
67Diaphragmatic weakness (HP:0009113)2.40349714
68Increased CSF lactate (HP:0002490)2.39261970
69Supranuclear gaze palsy (HP:0000605)2.38908874
70Postnatal microcephaly (HP:0005484)2.38305809
71Abnormality of the umbilical cord (HP:0010881)2.37948404
72Paraparesis (HP:0002385)2.35971851
73Pancytopenia (HP:0001876)2.34563777
74Hepatosplenomegaly (HP:0001433)2.34468673
75Hypoglycemic coma (HP:0001325)2.34315228
76Neuroendocrine neoplasm (HP:0100634)2.31984993
77Petechiae (HP:0000967)2.30226732
78Secondary amenorrhea (HP:0000869)2.30063206
79Pheochromocytoma (HP:0002666)2.29470243
80Abnormal protein glycosylation (HP:0012346)2.28994827
81Abnormal glycosylation (HP:0012345)2.28994827
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28994827
83Abnormal protein N-linked glycosylation (HP:0012347)2.28994827
84Autoamputation (HP:0001218)2.28137101
85Partial agenesis of the corpus callosum (HP:0001338)2.28007179
86Hyperglycinuria (HP:0003108)2.27481157
87Cerebral edema (HP:0002181)2.24318832
88Lipid accumulation in hepatocytes (HP:0006561)2.23925316
89Erythroderma (HP:0001019)2.23127375
90Hypoplasia of the thymus (HP:0000778)2.22403388
91Myopathic facies (HP:0002058)2.21859524
92Progressive macrocephaly (HP:0004481)2.18971656
93Rhabdomyolysis (HP:0003201)2.18651466
94Poor suck (HP:0002033)2.18458173
95Abnormal number of erythroid precursors (HP:0012131)2.18455958
96Akinesia (HP:0002304)2.16527002
97Abnormality of cells of the erythroid lineage (HP:0012130)2.16034200
98Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15845420
99Oral leukoplakia (HP:0002745)2.15644849
100Seborrheic dermatitis (HP:0001051)2.15640389
101Slow saccadic eye movements (HP:0000514)2.14875749
102Pallor (HP:0000980)2.13853924
103Hyperbilirubinemia (HP:0002904)2.12947967
104Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12291565
105Hyperglycinemia (HP:0002154)2.12119144
106Increased muscle lipid content (HP:0009058)2.11852837
107Renal cortical cysts (HP:0000803)2.11197553
108Reticulocytosis (HP:0001923)2.11174310
109Deep venous thrombosis (HP:0002625)2.10430616
110CNS demyelination (HP:0007305)2.10397474
111Trismus (HP:0000211)2.10360678
112Premature skin wrinkling (HP:0100678)2.10093935
113Abnormality of fatty-acid metabolism (HP:0004359)2.09926706
114Hyperlipoproteinemia (HP:0010980)2.09114124
115Intention tremor (HP:0002080)2.05496339
116Distal lower limb muscle weakness (HP:0009053)2.04383125
117Respiratory failure (HP:0002878)2.03595550
118Reticulocytopenia (HP:0001896)2.03204718
119Exercise intolerance (HP:0003546)2.02827459
120Aplasia/Hypoplasia of the thymus (HP:0010515)2.01713948
121Increased serum lactate (HP:0002151)2.01404165
122Macrocytic anemia (HP:0001972)1.99170898
123Cerebral palsy (HP:0100021)1.97481935
124Entropion (HP:0000621)1.97464384
125Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96113167
126Dicarboxylic aciduria (HP:0003215)1.96113167
127Abnormality of glycine metabolism (HP:0010895)1.95728760
128Abnormality of serine family amino acid metabolism (HP:0010894)1.95728760
129Hypobetalipoproteinemia (HP:0003563)1.95286511
130Abnormality of serum amino acid levels (HP:0003112)1.95246862
131Asymmetric septal hypertrophy (HP:0001670)1.95087518
132Confusion (HP:0001289)1.94531601
133Abnormal trabecular bone morphology (HP:0100671)1.93366299
134Dysmetria (HP:0001310)1.93291651
135Subcapsular cataract (HP:0000523)1.92895938
136Methylmalonic acidemia (HP:0002912)1.91606080
137Absent septum pellucidum (HP:0001331)1.91574895
138Acute hepatic failure (HP:0006554)1.91465504
139Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89959164
140Abnormal cartilage morphology (HP:0002763)1.89608434
141Thickened helices (HP:0000391)1.88908294
142Neck muscle weakness (HP:0000467)1.88376658
143IgM deficiency (HP:0002850)1.88028124
144Increased intramyocellular lipid droplets (HP:0012240)1.87798125
145Exertional dyspnea (HP:0002875)1.86840282
146Xanthomatosis (HP:0000991)1.86653460
147Dry hair (HP:0011359)1.85994709
148Adrenal hypoplasia (HP:0000835)1.84923173
149Abnormal hemoglobin (HP:0011902)1.84771209
150Testicular atrophy (HP:0000029)1.84535074
151Hypertensive crisis (HP:0100735)1.84145611
152Abnormality of the fetal cardiovascular system (HP:0010948)1.83850582
153Abnormal umbilical cord blood vessels (HP:0011403)1.83850582
154Single umbilical artery (HP:0001195)1.83850582
155Breast hypoplasia (HP:0003187)1.82937854
156Termporal pattern (HP:0011008)1.81603023
157Insidious onset (HP:0003587)1.81603023
158Spastic tetraparesis (HP:0001285)1.80755326
159Death in infancy (HP:0001522)1.80021452
160Barrel-shaped chest (HP:0001552)1.78048814
161Anteriorly placed anus (HP:0001545)1.77864732
162Birth length less than 3rd percentile (HP:0003561)1.77345761
163Morphological abnormality of the pyramidal tract (HP:0002062)1.76732716
164Stridor (HP:0010307)1.76092148
165Abnormality of methionine metabolism (HP:0010901)1.75562834
166Abnormality of the gallbladder (HP:0005264)1.74998773
167Lethargy (HP:0001254)1.74698662
168Segmental peripheral demyelination/remyelination (HP:0003481)1.74226554
169Prolonged neonatal jaundice (HP:0006579)1.73210884
170Lactic acidosis (HP:0003128)1.73001500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.26173968
2OXSR14.55029665
3VRK24.03797736
4CDK193.74892804
5SMG13.23749715
6PBK3.09405508
7SCYL23.06379032
8EPHB12.75794548
9WNK42.72899204
10SRPK12.57402782
11BCR2.46538667
12MET2.31517203
13LIMK12.19468615
14CDC72.15000286
15TESK22.13224136
16CSNK1G32.13217791
17ERN12.12793630
18BUB12.12422570
19CDK81.95294839
20PKN11.88321766
21MAPKAPK51.85354438
22TLK11.85179432
23ICK1.83464026
24TRIM281.70138309
25WNK11.69435733
26MST41.67946836
27ARAF1.66678328
28CSNK1A1L1.65290135
29NME21.63877760
30CSNK1G11.61506725
31FGR1.59853439
32NUAK11.59358519
33ZAK1.59105374
34EIF2AK11.53899843
35STK161.52572839
36TESK11.45626102
37DYRK21.45344422
38GRK61.43921449
39PLK41.43520684
40CSNK1G21.42479483
41PRPF4B1.38601949
42CCNB11.33671151
43UHMK11.31065346
44TSSK61.22285440
45NTRK11.20613309
46TNIK1.18187986
47CLK11.14990940
48ERBB41.13030499
49ROCK21.12240868
50NME11.12219755
51EIF2AK21.10178678
52TAF11.08066156
53DAPK11.07068500
54RPS6KA51.05955745
55STK101.05083005
56SIK31.04838576
57CDK41.04398931
58PNCK1.02693820
59AURKA1.02681099
60BCKDK1.01374413
61ABL21.00598449
62RPS6KB21.00144748
63NEK60.99667567
64TBK10.96108335
65TAOK20.95996636
66PLK10.93694977
67CDK140.90962009
68PAK60.90093813
69CDK90.89530967
70PLK30.87678018
71VRK10.87526575
72CAMK2G0.87455662
73PASK0.86151332
74CAMK2D0.84985328
75ATR0.83771467
76PRKCQ0.80009547
77CAMK2B0.79998252
78PIM10.79647562
79CDK11A0.79204142
80DYRK30.78987671
81MAP3K100.78857588
82CDK150.78622369
83NEK10.77707658
84BMPR1B0.76720168
85BRAF0.74472708
86MAPK110.74283154
87LRRK20.73087389
88MAP2K30.71366820
89AURKB0.70754854
90IKBKE0.70356090
91PAK10.70095655
92MAP3K80.70072810
93PIK3CG0.69126125
94CDK180.67865153
95CHEK10.64992719
96RPS6KA40.64398913
97PDK20.64209166
98KSR20.63850019
99WEE10.63461965
100TYK20.62623089
101STK40.61777327
102MAP3K140.59430029
103PAK40.58860842
104MOS0.58340139
105TRPM70.58162065
106TAOK10.57473937
107MAP2K20.57152918
108IRAK30.56698781
109RAF10.55922277
110MAP3K30.53188923
111MAP3K110.53089917
112PRKCI0.52751088
113PDPK10.52613160
114BRSK10.52176155
115MAP3K130.51686908
116MUSK0.51633292
117MARK20.50726088
118PINK10.49768232
119ITK0.49176698
120CSNK2A10.47966024
121CDK60.47635516
122CSF1R0.47104260
123DMPK0.46190847
124CSNK1D0.46004642
125PRKD10.45942493
126FES0.45904399
127MAP4K10.42940963
128PIM20.42819385
129AKT20.39156049
130CDK50.37860265
131TRIB30.37166364
132MAPKAPK20.36817173
133ZAP700.36465836
134KDR0.36188785
135CDK20.36110752
136TEC0.35862131
137BTK0.35443033
138CSNK1A10.34885780
139ALK0.34814825
140CHEK20.34083133
141EIF2AK30.33638167
142CAMK2A0.33356253
143LCK0.32423347
144MKNK10.30321713
145ABL10.30013039
146OBSCN0.28857398
147NEK20.28694282
148FGFR20.28298382
149PRKACB0.27645365
150SGK4940.25498137
151SGK2230.25498137
152TAOK30.25399261
153CDK70.24680502
154CSNK2A20.23288395
155IKBKB0.22145868
156PAK30.21325347
157TTK0.21079672
158FYN0.20717791
159MELK0.18887017
160LATS20.17787167

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.18259033
2Fatty acid elongation_Homo sapiens_hsa000624.00945759
3Steroid biosynthesis_Homo sapiens_hsa001003.90259729
4Vitamin B6 metabolism_Homo sapiens_hsa007503.53199139
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.16139934
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.81583793
7Oxidative phosphorylation_Homo sapiens_hsa001902.63543103
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.61400953
9Protein export_Homo sapiens_hsa030602.58058341
10Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.55306486
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.43298153
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36260553
13Ether lipid metabolism_Homo sapiens_hsa005652.29571208
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.28779097
15Parkinsons disease_Homo sapiens_hsa050122.14182700
16RNA polymerase_Homo sapiens_hsa030202.13115112
17Proteasome_Homo sapiens_hsa030502.11072414
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.10571532
19Folate biosynthesis_Homo sapiens_hsa007902.05821825
20Sulfur metabolism_Homo sapiens_hsa009201.79433423
21Histidine metabolism_Homo sapiens_hsa003401.74018687
22Sulfur relay system_Homo sapiens_hsa041221.73779476
23Ribosome_Homo sapiens_hsa030101.71136431
24Butanoate metabolism_Homo sapiens_hsa006501.70513665
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.57736126
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56495839
27Arginine and proline metabolism_Homo sapiens_hsa003301.52334146
28Linoleic acid metabolism_Homo sapiens_hsa005911.52101362
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50631555
30Alzheimers disease_Homo sapiens_hsa050101.48864800
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46834859
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39608353
33Glutathione metabolism_Homo sapiens_hsa004801.37037000
34Huntingtons disease_Homo sapiens_hsa050161.36912198
35Basal transcription factors_Homo sapiens_hsa030221.32114685
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30038037
37Sphingolipid metabolism_Homo sapiens_hsa006001.27418057
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27073881
39Peroxisome_Homo sapiens_hsa041461.22485348
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18044982
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.13240036
42Primary immunodeficiency_Homo sapiens_hsa053401.12597882
43Propanoate metabolism_Homo sapiens_hsa006401.08868622
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.04222217
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98659152
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95543918
47Fatty acid metabolism_Homo sapiens_hsa012120.94210922
48mRNA surveillance pathway_Homo sapiens_hsa030150.94000155
49Fructose and mannose metabolism_Homo sapiens_hsa000510.93649949
50Metabolic pathways_Homo sapiens_hsa011000.92483357
51Galactose metabolism_Homo sapiens_hsa000520.89415340
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88337723
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87155914
54Pyruvate metabolism_Homo sapiens_hsa006200.86115086
55Pentose phosphate pathway_Homo sapiens_hsa000300.83300280
56N-Glycan biosynthesis_Homo sapiens_hsa005100.79207162
57Pyrimidine metabolism_Homo sapiens_hsa002400.77182984
58Chemical carcinogenesis_Homo sapiens_hsa052040.76310741
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.76273314
60beta-Alanine metabolism_Homo sapiens_hsa004100.75293184
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.73649353
62Herpes simplex infection_Homo sapiens_hsa051680.68514247
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68232107
64Fanconi anemia pathway_Homo sapiens_hsa034600.68143077
65Fatty acid degradation_Homo sapiens_hsa000710.67920078
66Systemic lupus erythematosus_Homo sapiens_hsa053220.67572528
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66169192
68Tryptophan metabolism_Homo sapiens_hsa003800.65277545
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65196079
70Tyrosine metabolism_Homo sapiens_hsa003500.64519223
71Retinol metabolism_Homo sapiens_hsa008300.63996375
72Non-homologous end-joining_Homo sapiens_hsa034500.62461314
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.62386331
74Nucleotide excision repair_Homo sapiens_hsa034200.61953479
75Cardiac muscle contraction_Homo sapiens_hsa042600.60846348
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60799427
77DNA replication_Homo sapiens_hsa030300.60544323
78p53 signaling pathway_Homo sapiens_hsa041150.58886803
79Arachidonic acid metabolism_Homo sapiens_hsa005900.58618009
80Homologous recombination_Homo sapiens_hsa034400.58291648
81Regulation of autophagy_Homo sapiens_hsa041400.57751487
82Epstein-Barr virus infection_Homo sapiens_hsa051690.56953627
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55889766
84Spliceosome_Homo sapiens_hsa030400.55744108
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.54383635
86Caffeine metabolism_Homo sapiens_hsa002320.50629120
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50508554
88Lysine degradation_Homo sapiens_hsa003100.50252739
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48800928
90Acute myeloid leukemia_Homo sapiens_hsa052210.48778025
91Biosynthesis of amino acids_Homo sapiens_hsa012300.45964578
92Thyroid cancer_Homo sapiens_hsa052160.44835861
93Carbon metabolism_Homo sapiens_hsa012000.42809701
94Renal cell carcinoma_Homo sapiens_hsa052110.42234835
95Fat digestion and absorption_Homo sapiens_hsa049750.41507383
96Complement and coagulation cascades_Homo sapiens_hsa046100.41066254
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39906375
98Purine metabolism_Homo sapiens_hsa002300.39670160
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.39137648
100Vitamin digestion and absorption_Homo sapiens_hsa049770.38650741
101Selenocompound metabolism_Homo sapiens_hsa004500.37410013
102Viral carcinogenesis_Homo sapiens_hsa052030.36790272
103Malaria_Homo sapiens_hsa051440.36679728
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35271094
105Apoptosis_Homo sapiens_hsa042100.34869808
106Mismatch repair_Homo sapiens_hsa034300.33936403
107Cell cycle_Homo sapiens_hsa041100.32895081
108Oocyte meiosis_Homo sapiens_hsa041140.32058155
109Glycerolipid metabolism_Homo sapiens_hsa005610.31760859
110Phenylalanine metabolism_Homo sapiens_hsa003600.29671490
111Shigellosis_Homo sapiens_hsa051310.28708592
112ABC transporters_Homo sapiens_hsa020100.28511571
113Axon guidance_Homo sapiens_hsa043600.26755428
114Starch and sucrose metabolism_Homo sapiens_hsa005000.26752096
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26499330
116One carbon pool by folate_Homo sapiens_hsa006700.26099810
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.24499614
118Tight junction_Homo sapiens_hsa045300.24304723
119Collecting duct acid secretion_Homo sapiens_hsa049660.23947633
120Endocytosis_Homo sapiens_hsa041440.22931372
121Alcoholism_Homo sapiens_hsa050340.21710143
122Base excision repair_Homo sapiens_hsa034100.20673665
123Autoimmune thyroid disease_Homo sapiens_hsa053200.19770052
124RNA transport_Homo sapiens_hsa030130.18692375
125Arginine biosynthesis_Homo sapiens_hsa002200.18312587
126PPAR signaling pathway_Homo sapiens_hsa033200.16479414
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15420538
128RNA degradation_Homo sapiens_hsa030180.13960382
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12506581

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