SLC25A39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SLC25 transporter or mitochondrial carrier family of proteins. Members of this family are encoded by the nuclear genome while their protein products are usually embedded in the inner mitochondrial membrane and exhibit wide-ranging substrate specificity. Although the encoded protein is currently considered an orphan transporter, this protein is related to other carriers known to transport amino acids. This protein may play a role in iron homeostasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.27012906
2L-phenylalanine metabolic process (GO:0006558)6.27012906
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.14304648
4L-phenylalanine catabolic process (GO:0006559)6.14304648
5oxygen transport (GO:0015671)5.96211821
6cysteine metabolic process (GO:0006534)5.52266277
7glyoxylate metabolic process (GO:0046487)5.50969464
8negative regulation of cell killing (GO:0031342)5.39584691
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.39584691
10aromatic amino acid family catabolic process (GO:0009074)5.34394711
11lysine metabolic process (GO:0006553)5.27203312
12lysine catabolic process (GO:0006554)5.27203312
13protoporphyrinogen IX metabolic process (GO:0046501)5.19078407
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.10048579
15positive regulation by organism of defense response of other organism involved in symbiotic interact5.10048579
16modulation by symbiont of host immune response (GO:0052553)5.10048579
17positive regulation by symbiont of host defense response (GO:0052509)5.10048579
18modulation by symbiont of host defense response (GO:0052031)5.10048579
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.10048579
20sulfur amino acid catabolic process (GO:0000098)5.05984746
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03709828
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.98295020
23neutrophil activation involved in immune response (GO:0002283)4.94803659
24hemoglobin metabolic process (GO:0020027)4.92811836
25serine family amino acid catabolic process (GO:0009071)4.87972346
26gas transport (GO:0015669)4.81254400
27glycine metabolic process (GO:0006544)4.67015905
28tryptophan catabolic process (GO:0006569)4.66805675
29indole-containing compound catabolic process (GO:0042436)4.66805675
30indolalkylamine catabolic process (GO:0046218)4.66805675
31kynurenine metabolic process (GO:0070189)4.66800596
32antigen processing and presentation of endogenous antigen (GO:0019883)4.66049694
33amino-acid betaine metabolic process (GO:0006577)4.61032855
34serine family amino acid metabolic process (GO:0009069)4.56254385
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.52227969
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.48113710
37alpha-linolenic acid metabolic process (GO:0036109)4.44076232
38tryptophan metabolic process (GO:0006568)4.43461972
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.43445596
40serine family amino acid biosynthetic process (GO:0009070)4.43126009
41homocysteine metabolic process (GO:0050667)4.33944930
42detection of bacterium (GO:0016045)4.33802867
43protoporphyrinogen IX biosynthetic process (GO:0006782)4.31628029
44bile acid biosynthetic process (GO:0006699)4.30605161
45urea metabolic process (GO:0019627)4.27967317
46urea cycle (GO:0000050)4.27967317
47detection of other organism (GO:0098543)4.26841993
483-UTR-mediated mRNA stabilization (GO:0070935)4.23191735
49positive regulation of gamma-delta T cell activation (GO:0046645)4.22863722
50modulation by virus of host process (GO:0019054)4.21628518
51aromatic amino acid family metabolic process (GO:0009072)4.06821544
52nitrogen cycle metabolic process (GO:0071941)4.02850415
53drug transmembrane transport (GO:0006855)4.02283068
54alpha-amino acid catabolic process (GO:1901606)4.00112636
55negative regulation of fibrinolysis (GO:0051918)3.99546143
56aspartate family amino acid catabolic process (GO:0009068)3.96653523
57erythrocyte maturation (GO:0043249)3.94802481
58negative regulation of phagocytosis (GO:0050765)3.94011594
59response to peptidoglycan (GO:0032494)3.91497551
60urate metabolic process (GO:0046415)3.88774161
61cellular modified amino acid catabolic process (GO:0042219)3.86630082
62carnitine metabolic process (GO:0009437)3.85715655
63cellular amino acid catabolic process (GO:0009063)3.83710354
64regulation of B cell receptor signaling pathway (GO:0050855)3.79524298
65high-density lipoprotein particle remodeling (GO:0034375)3.79320715
66respiratory burst (GO:0045730)3.77338215
67peptidyl-glutamic acid carboxylation (GO:0017187)3.76762475
68protein carboxylation (GO:0018214)3.76762475
69leukocyte aggregation (GO:0070486)3.75879744
70modulation by symbiont of host cellular process (GO:0044068)3.75528635
71fatty acid beta-oxidation (GO:0006635)3.73761030
72regulation of triglyceride catabolic process (GO:0010896)3.71155760
73cellular ketone body metabolic process (GO:0046950)3.68239104
74erythrocyte development (GO:0048821)3.67087735
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.66115640
76neutrophil activation (GO:0042119)3.65579760
77valine metabolic process (GO:0006573)3.65568357
782-oxoglutarate metabolic process (GO:0006103)3.64928007
79ethanol oxidation (GO:0006069)3.64690642
80bile acid metabolic process (GO:0008206)3.63364921
81regulation of protein activation cascade (GO:2000257)3.61894273
82regulation of fibrinolysis (GO:0051917)3.60694073
83aldehyde catabolic process (GO:0046185)3.60262886
84short-chain fatty acid metabolic process (GO:0046459)3.60040946
85negative regulation of cholesterol transport (GO:0032375)3.59264314
86negative regulation of sterol transport (GO:0032372)3.59264314
87tyrosine metabolic process (GO:0006570)3.59045537
88macrophage activation involved in immune response (GO:0002281)3.58857704
89complement activation, alternative pathway (GO:0006957)3.58804429
90drug transport (GO:0015893)3.58404848
91fatty acid oxidation (GO:0019395)3.56627881
92drug catabolic process (GO:0042737)3.54998735
93hepatocyte apoptotic process (GO:0097284)3.54548093
94acetyl-CoA metabolic process (GO:0006084)3.52017878
95GDP-mannose metabolic process (GO:0019673)3.51872213
96acylglycerol homeostasis (GO:0055090)3.51167910
97triglyceride homeostasis (GO:0070328)3.51167910
98carboxylic acid catabolic process (GO:0046395)3.49449530
99organic acid catabolic process (GO:0016054)3.49449530
100lipid oxidation (GO:0034440)3.47952528
101response to mercury ion (GO:0046689)3.47114103
102negative regulation of erythrocyte differentiation (GO:0045647)3.46983005
103cellular response to virus (GO:0098586)3.42932510
104fatty acid catabolic process (GO:0009062)3.42813443
105response to interleukin-15 (GO:0070672)3.42727808
106plasma lipoprotein particle clearance (GO:0034381)3.41597301
107benzene-containing compound metabolic process (GO:0042537)3.41367517
108positive regulation of Cdc42 GTPase activity (GO:0043089)3.40477255
109detection of external biotic stimulus (GO:0098581)3.39962923
110response to host immune response (GO:0052572)3.39847485
111response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.39847485
112negative regulation of lymphocyte mediated immunity (GO:0002707)3.39846087
113regulation of complement activation (GO:0030449)3.39426409
114glutamate metabolic process (GO:0006536)3.38934811
115granulocyte activation (GO:0036230)3.38424272
116branched-chain amino acid catabolic process (GO:0009083)3.35523605
117response to nitrosative stress (GO:0051409)3.34469987
118regulation of cholesterol homeostasis (GO:2000188)3.34432966
119regulation of mast cell degranulation (GO:0043304)3.33639695
120monocarboxylic acid catabolic process (GO:0072329)3.33121719
121reverse cholesterol transport (GO:0043691)3.32419967
122coenzyme catabolic process (GO:0009109)3.32030943
123L-serine metabolic process (GO:0006563)3.31293739
124regulation of interferon-beta biosynthetic process (GO:0045357)3.30610588
125proline metabolic process (GO:0006560)3.30520561
126viral protein processing (GO:0019082)3.30293484
127regulation of cholesterol esterification (GO:0010872)3.30126118
128cellular glucuronidation (GO:0052695)3.29907809
129tricarboxylic acid metabolic process (GO:0072350)3.28494241
130protein-lipid complex remodeling (GO:0034368)3.27466386
131macromolecular complex remodeling (GO:0034367)3.27466386
132plasma lipoprotein particle remodeling (GO:0034369)3.27466386
133branched-chain amino acid metabolic process (GO:0009081)3.26851284
134organic cation transport (GO:0015695)3.24830726
135indolalkylamine metabolic process (GO:0006586)3.22565938
136positive regulation of triglyceride lipase activity (GO:0061365)3.20723355
137positive regulation of lipoprotein lipase activity (GO:0051006)3.20723355
138ketone body metabolic process (GO:1902224)3.20114367
139folic acid metabolic process (GO:0046655)3.19862969
1404-hydroxyproline metabolic process (GO:0019471)3.19277501
141response to host (GO:0075136)3.19257933
142response to host defenses (GO:0052200)3.19257933
143response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.19257933
144positive regulation of fibroblast migration (GO:0010763)3.17796574
145amine catabolic process (GO:0009310)3.17601632
146cellular biogenic amine catabolic process (GO:0042402)3.17601632
147imidazole-containing compound metabolic process (GO:0052803)3.17383215
148exogenous drug catabolic process (GO:0042738)3.16754563
149regulation of platelet aggregation (GO:0090330)3.16667272
150negative regulation of fatty acid biosynthetic process (GO:0045717)3.15888768
151regulation of myeloid leukocyte mediated immunity (GO:0002886)3.14204729
152one-carbon metabolic process (GO:0006730)3.13284830
153cellular response to interleukin-15 (GO:0071350)3.12999772
154negative regulation of leukocyte mediated immunity (GO:0002704)3.10526321
155heme transport (GO:0015886)3.09421649
156pentose-phosphate shunt (GO:0006098)3.09320143
157positive regulation of granulocyte differentiation (GO:0030854)3.09257481
158sulfur amino acid metabolic process (GO:0000096)3.08844896
159negative regulation of interleukin-12 production (GO:0032695)3.08345413
160regulation of leukocyte degranulation (GO:0043300)3.06428733
161positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.04027462
162negative regulation of necroptotic process (GO:0060546)2.98749986
163leukocyte degranulation (GO:0043299)2.97544510
164regulation of mast cell activation involved in immune response (GO:0033006)2.94666570
165regulation of necroptotic process (GO:0060544)2.93645319
166myeloid cell activation involved in immune response (GO:0002275)2.92395741
167virion assembly (GO:0019068)2.92290414
168regulation of gamma-delta T cell activation (GO:0046643)2.91904344
169immunoglobulin mediated immune response (GO:0016064)2.91431769
170neutrophil mediated immunity (GO:0002446)2.88308263
171myeloid cell development (GO:0061515)2.88084284
172regulation of superoxide anion generation (GO:0032928)2.86540740
173detection of biotic stimulus (GO:0009595)2.86370644
174cellular extravasation (GO:0045123)2.83937253
175negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.83590626
176leukocyte migration involved in inflammatory response (GO:0002523)2.82943681
177negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78279943
178detection of molecule of bacterial origin (GO:0032490)2.74445510
179positive thymic T cell selection (GO:0045059)2.74413120
180regulation of chromatin binding (GO:0035561)2.73245902
181NADPH regeneration (GO:0006740)2.70890201
182* heme biosynthetic process (GO:0006783)2.69132665
183antigen processing and presentation via MHC class Ib (GO:0002475)2.65323778
184* porphyrin-containing compound biosynthetic process (GO:0006779)2.65251168
185deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65004140
186microglial cell activation (GO:0001774)2.64894861
187regulation of regulated secretory pathway (GO:1903305)2.62970328
188negative regulation of T cell mediated immunity (GO:0002710)2.62779414
189negative regulation of execution phase of apoptosis (GO:1900118)2.62630349
190regulation of gamma-delta T cell differentiation (GO:0045586)2.62397087
191regulation of T cell tolerance induction (GO:0002664)2.60351286
192negative regulation of glial cell proliferation (GO:0060253)2.58762773
193NIK/NF-kappaB signaling (GO:0038061)2.58228641
194thymic T cell selection (GO:0045061)2.56900356
195negative regulation of cAMP-mediated signaling (GO:0043951)2.56307750
196regulation of defense response to virus by virus (GO:0050690)2.56141426
197positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.55585178
198negative regulation of interleukin-6 production (GO:0032715)2.55564411
199macrophage activation (GO:0042116)2.54666526
200regulation of B cell differentiation (GO:0045577)2.52922821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.44134437
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.18556265
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.78063244
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.46135309
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.74511359
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.65609605
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.46585844
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09386630
9VDR_21846776_ChIP-Seq_THP-1_Human3.02288424
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.97191606
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.79049976
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42333863
13* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39373050
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.11989864
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.10680383
16MAF_26560356_Chip-Seq_TH1_Human2.07497073
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.06601833
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04617487
19VDR_24763502_ChIP-Seq_THP-1_Human2.00563323
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99641156
21* TCF7_22412390_ChIP-Seq_EML_Mouse1.98718226
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.96087839
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.95277271
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92947098
25* UTX_26944678_Chip-Seq_JUKART_Human1.90319261
26SPI1_23547873_ChIP-Seq_NB4_Human1.88193412
27* RUNX1_22412390_ChIP-Seq_EML_Mouse1.87955750
28KDM2B_26808549_Chip-Seq_DND41_Human1.87223107
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84656014
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82978913
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82759904
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82312065
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82197049
34GATA1_19941826_ChIP-Seq_K562_Human1.81256604
35SCL_19346495_ChIP-Seq_HPC-7_Human1.80517418
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.77618538
37MAF_26560356_Chip-Seq_TH2_Human1.77382878
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75089678
39E2F7_22180533_ChIP-Seq_HELA_Human1.74029699
40* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73142313
41* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69796371
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68954968
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65973113
44* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64839478
45* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63925199
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63580127
47ZNF263_19887448_ChIP-Seq_K562_Human1.62849850
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.62719184
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61924230
50SPI1_23127762_ChIP-Seq_K562_Human1.61331160
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60385953
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58159728
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.57433597
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56605004
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.53721942
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52502946
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52064529
58* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49258839
59* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47696892
60NCOR1_26117541_ChIP-Seq_K562_Human1.47246654
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.47139029
62CLOCK_20551151_ChIP-Seq_293T_Human1.41144939
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40745083
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39822511
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39446008
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37020713
67MYB_26560356_Chip-Seq_TH1_Human1.36646529
68* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36568124
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.36098366
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35735378
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35016791
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33391523
73* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32970745
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31998647
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30413164
76MYB_26560356_Chip-Seq_TH2_Human1.30235302
77TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.29650032
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29194022
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27897139
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27006923
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25530735
82STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25421849
83AR_21909140_ChIP-Seq_LNCAP_Human1.25130225
84ETS1_20019798_ChIP-Seq_JURKAT_Human1.24260546
85* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23397156
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21853084
87IRF8_27001747_Chip-Seq_BMDM_Mouse1.20524382
88* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19352447
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19149819
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18507726
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18441158
92* XRN2_22483619_ChIP-Seq_HELA_Human1.17435479
93DCP1A_22483619_ChIP-Seq_HELA_Human1.16946372
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16824235
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16645936
96* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16481344
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16271006
98GATA2_19941826_ChIP-Seq_K562_Human1.13637089
99SMC4_20622854_ChIP-Seq_HELA_Human1.11638143
100KDM2B_26808549_Chip-Seq_JURKAT_Human1.11564669
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11259545
102LXR_22292898_ChIP-Seq_THP-1_Human1.10694936
103FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09322090
104ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08739230
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08399775
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08076281
107FOXM1_23109430_ChIP-Seq_U2OS_Human1.06873145
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06061108
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05204948
110* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04213847
111* TET1_21451524_ChIP-Seq_MESCs_Mouse1.03718919
112GABP_19822575_ChIP-Seq_HepG2_Human1.03636453
113TFEB_21752829_ChIP-Seq_HELA_Human1.03278216
114* KDM2B_26808549_Chip-Seq_K562_Human1.03075611
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02963236
116GABP_17652178_ChIP-ChIP_JURKAT_Human1.02917868
117* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02212857
118EST1_17652178_ChIP-ChIP_JURKAT_Human1.02054262
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01910347
120* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01350138
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01045380
122CTCF_21964334_Chip-Seq_Bcells_Human0.99931936
123CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99753195
124SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99421840
125SRF_21415370_ChIP-Seq_HL-1_Mouse0.98687811
126* ATF3_27146783_Chip-Seq_COLON_Human0.98538024
127NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97697835
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97566681
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97059109
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95010861
131* RARA_24833708_ChIP-Seq_LIVER_Mouse0.93540800
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93423369
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93117740
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91502575
135SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91065742
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89599665
137HNF4A_19822575_ChIP-Seq_HepG2_Human0.88803820
138KDM5A_27292631_Chip-Seq_BREAST_Human0.88786296
139DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88684966
140* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88619024
141BCOR_27268052_Chip-Seq_Bcells_Human0.87968209
142* RACK7_27058665_Chip-Seq_MCF-7_Human0.87466240
143* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.87465578
144OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86386198
145P68_20966046_ChIP-Seq_HELA_Human0.84626638
146* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84103017
147GATA6_25053715_ChIP-Seq_YYC3_Human0.83989018
148GATA4_25053715_ChIP-Seq_YYC3_Human0.83699082
149PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83581177
150YY1_22570637_ChIP-Seq_MALME-3M_Human0.83451507
151* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83392103
152RARB_24833708_ChIP-Seq_LIVER_Mouse0.83298379
153BCL6_27268052_Chip-Seq_Bcells_Human0.82763411
154SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82420358
155STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81770989
156FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81114375
157ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81044384
158ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80014218
159* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.79376134
160GATA1_22025678_ChIP-Seq_K562_Human0.79322456
161TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79048243
162* FOXP1_21924763_ChIP-Seq_HESCs_Human0.78497379
163ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77965507
164ELF1_20517297_ChIP-Seq_JURKAT_Human0.77423920
165SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77368896
166* MYC_22102868_ChIP-Seq_BL_Human0.76848389
167PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76732484
168ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76648445
169PHF8_20622854_ChIP-Seq_HELA_Human0.76623862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.90419094
2MP0005360_urolithiasis6.37537162
3MP0005365_abnormal_bile_salt4.96476339
4MP0005085_abnormal_gallbladder_physiolo4.88045460
5MP0003806_abnormal_nucleotide_metabolis4.33215888
6MP0008875_abnormal_xenobiotic_pharmacok3.91850737
7MP0003436_decreased_susceptibility_to3.79588789
8MP0003303_peritoneal_inflammation3.25901074
9MP0009840_abnormal_foam_cell3.09468979
10MP0008260_abnormal_autophagy3.07925684
11MP0003252_abnormal_bile_duct3.04137393
12MP0005332_abnormal_amino_acid3.02011165
13MP0005083_abnormal_biliary_tract2.94158412
14MP0003724_increased_susceptibility_to2.94151992
15MP0003195_calcinosis2.90716403
16MP0010329_abnormal_lipoprotein_level2.75510399
17MP0002419_abnormal_innate_immunity2.50374909
18MP0005025_abnormal_response_to2.42294642
19MP0004019_abnormal_vitamin_homeostasis2.41721820
20MP0001666_abnormal_nutrient_absorption2.40597677
21MP0001835_abnormal_antigen_presentation2.38092083
22MP0000685_abnormal_immune_system2.34258538
23MP0005464_abnormal_platelet_physiology2.28661116
24MP0003763_abnormal_thymus_physiology2.19544320
25MP0002138_abnormal_hepatobiliary_system2.12728501
26MP0009333_abnormal_splenocyte_physiolog2.11114815
27MP0005387_immune_system_phenotype2.10116893
28MP0001790_abnormal_immune_system2.10116893
29MP0003191_abnormal_cellular_cholesterol2.08730382
30MP0002420_abnormal_adaptive_immunity2.08374212
31MP0003186_abnormal_redox_activity2.07570737
32MP0005000_abnormal_immune_tolerance2.07358718
33MP0001819_abnormal_immune_cell2.06720118
34MP0001800_abnormal_humoral_immune2.05372839
35MP0009643_abnormal_urine_homeostasis2.03431331
36MP0009785_altered_susceptibility_to2.00218985
37MP0005671_abnormal_response_to1.99937540
38MP0002398_abnormal_bone_marrow1.97729420
39MP0002723_abnormal_immune_serum1.93651787
40MP0009278_abnormal_bone_marrow1.93218222
41MP0000609_abnormal_liver_physiology1.92934423
42MP0005319_abnormal_enzyme/_coenzyme1.88957684
43MP0002405_respiratory_system_inflammati1.88696250
44MP0006082_CNS_inflammation1.85637152
45MP0002452_abnormal_antigen_presenting1.81868770
46MP0003866_abnormal_defecation1.79632086
47MP0003172_abnormal_lysosome_physiology1.79561558
48MP0002118_abnormal_lipid_homeostasis1.76310764
49MP0003705_abnormal_hypodermis_morpholog1.75883518
50MP0002396_abnormal_hematopoietic_system1.74632284
51MP0003878_abnormal_ear_physiology1.73081787
52MP0005377_hearing/vestibular/ear_phenot1.73081787
53MP0001545_abnormal_hematopoietic_system1.72360036
54MP0005397_hematopoietic_system_phenotyp1.72360036
55MP0003656_abnormal_erythrocyte_physiolo1.72111662
56MP0000490_abnormal_crypts_of1.70570692
57MP0002722_abnormal_immune_system1.68638401
58MP0004381_abnormal_hair_follicle1.66885165
59MP0006036_abnormal_mitochondrial_physio1.65087667
60MP0004947_skin_inflammation1.64628866
61MP0001764_abnormal_homeostasis1.64052617
62MP0000716_abnormal_immune_system1.63986188
63MP0005670_abnormal_white_adipose1.62661964
64MP0001533_abnormal_skeleton_physiology1.60570199
65MP0000703_abnormal_thymus_morphology1.60123738
66MP0005636_abnormal_mineral_homeostasis1.58590943
67MP0002429_abnormal_blood_cell1.57619828
68MP0000689_abnormal_spleen_morphology1.57485820
69MP0010155_abnormal_intestine_physiology1.56086874
70MP0000858_altered_metastatic_potential1.53515640
71MP0002148_abnormal_hypersensitivity_rea1.53320582
72MP0005075_abnormal_melanosome_morpholog1.47084201
73MP0001873_stomach_inflammation1.47081043
74MP0004043_abnormal_pH_regulation1.45867719
75MP0005584_abnormal_enzyme/coenzyme_acti1.44580492
76MP0001756_abnormal_urination1.37613356
77MP0001845_abnormal_inflammatory_respons1.36494089
78MP0004858_abnormal_nervous_system1.30607123
79MP0000598_abnormal_liver_morphology1.29214496
80MP0003868_abnormal_feces_composition1.25672602
81MP0003453_abnormal_keratinocyte_physiol1.25315637
82MP0005310_abnormal_salivary_gland1.25154042
83MP0005220_abnormal_exocrine_pancreas1.22193238
84MP0003183_abnormal_peptide_metabolism1.12044422
85MP0005410_abnormal_fertilization1.11928776
86MP0005076_abnormal_cell_differentiation1.11707670
87MP0001851_eye_inflammation1.10437056
88MP0003566_abnormal_cell_adhesion1.06760465
89MP0005451_abnormal_body_composition1.05263421
90MP0005666_abnormal_adipose_tissue1.00669552
91MP0004808_abnormal_hematopoietic_stem0.99490923
92MP0002136_abnormal_kidney_physiology0.98623434
93MP0002277_abnormal_respiratory_mucosa0.97977719
94MP0000465_gastrointestinal_hemorrhage0.97389264
95MP0000015_abnormal_ear_pigmentation0.97048237
96MP0003828_pulmonary_edema0.95431596
97MP0001849_ear_inflammation0.94664702
98MP0001765_abnormal_ion_homeostasis0.92166860
99MP0009931_abnormal_skin_appearance0.90814186
100MP0003075_altered_response_to0.89971460
101MP0006035_abnormal_mitochondrial_morpho0.89612002
102MP0005084_abnormal_gallbladder_morpholo0.87870206
103MP0002078_abnormal_glucose_homeostasis0.87630946
104MP0003011_delayed_dark_adaptation0.87443315
105MP0005266_abnormal_metabolism0.86817887
106MP0001663_abnormal_digestive_system0.86538540
107MP0004147_increased_porphyrin_level0.86444192
108MP0009642_abnormal_blood_homeostasis0.86304025
109MP0005058_abnormal_lysosome_morphology0.85290553
110MP0002019_abnormal_tumor_incidence0.83565322
111MP0009053_abnormal_anal_canal0.83531069
112MP0000313_abnormal_cell_death0.80894388
113MP0009763_increased_sensitivity_to0.80641451
114MP0003693_abnormal_embryo_hatching0.80003297
115MP0008469_abnormal_protein_level0.79431399
116MP0002653_abnormal_ependyma_morphology0.78776370
117MP0004264_abnormal_extraembryonic_tissu0.77348819
118MP0005376_homeostasis/metabolism_phenot0.77276812
119MP0000678_abnormal_parathyroid_gland0.74127022
120MP0004957_abnormal_blastocyst_morpholog0.73029178
121MP0008874_decreased_physiological_sensi0.71736349
122MP0009672_abnormal_birth_weight0.71236749
123MP0002971_abnormal_brown_adipose0.70045516
124MP0004510_myositis0.69437473
125MP0001661_extended_life_span0.68565221
126MP0003943_abnormal_hepatobiliary_system0.68288236
127MP0000358_abnormal_cell_content/0.67782608
128MP0002269_muscular_atrophy0.67267612
129MP0002998_abnormal_bone_remodeling0.66828055
130MP0002837_dystrophic_cardiac_calcinosis0.66797158
131MP0000343_altered_response_to0.66533659
132MP0010352_gastrointestinal_tract_polyps0.65977198
133MP0002166_altered_tumor_susceptibility0.65679500
134MP0005647_abnormal_sex_gland0.64718691
135MP0004883_abnormal_blood_vessel0.63585636
136MP0005408_hypopigmentation0.63037961
137MP0002332_abnormal_exercise_endurance0.62729598
138MP0010234_abnormal_vibrissa_follicle0.62003204
139MP0002970_abnormal_white_adipose0.61953560
140MP0005390_skeleton_phenotype0.59628638
141MP0005621_abnormal_cell_physiology0.59542648
142MP0004130_abnormal_muscle_cell0.59458987
143MP0005334_abnormal_fat_pad0.58885868
144MP0003646_muscle_fatigue0.58497724
145MP0009764_decreased_sensitivity_to0.56794210
146MP0002796_impaired_skin_barrier0.55563461
147MP0002135_abnormal_kidney_morphology0.55120674
148MP0005375_adipose_tissue_phenotype0.53471218
149MP0001944_abnormal_pancreas_morphology0.53102138
150MP0005023_abnormal_wound_healing0.53084924
151MP0001730_embryonic_growth_arrest0.52784806
152MP0003718_maternal_effect0.52418140
153MP0009697_abnormal_copulation0.51991869
154MP0009765_abnormal_xenobiotic_induced0.51826437
155MP0003959_abnormal_lean_body0.51045848
156MP0003111_abnormal_nucleus_morphology0.50970677
157MP0005501_abnormal_skin_physiology0.49577163
158MP0003221_abnormal_cardiomyocyte_apopto0.49519961
159MP0005395_other_phenotype0.49398673
160MP0005330_cardiomyopathy0.49003204
161MP0003300_gastrointestinal_ulcer0.48779633
162MP0004185_abnormal_adipocyte_glucose0.48602279
163MP0002928_abnormal_bile_duct0.48218957
164MP0003953_abnormal_hormone_level0.48066713
165MP0000604_amyloidosis0.44837971
166MP0003638_abnormal_response/metabolism_0.44274493
167MP0001929_abnormal_gametogenesis0.43671360
168MP0005535_abnormal_body_temperature0.43424057
169MP0010368_abnormal_lymphatic_system0.42912485
170MP0009115_abnormal_fat_cell0.39904782
171MP0008873_increased_physiological_sensi0.39897158
172MP0002132_abnormal_respiratory_system0.37386745
173MP0005448_abnormal_energy_balance0.37108688
174MP0000230_abnormal_systemic_arterial0.36307624
175MP0003283_abnormal_digestive_organ0.36024640
176MP0002080_prenatal_lethality0.35872114
177MP0000639_abnormal_adrenal_gland0.35442308

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)7.21256235
2Hypochromic anemia (HP:0001931)6.38431679
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.11480312
4Eczematoid dermatitis (HP:0000976)5.67321077
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.21074808
6Intrahepatic cholestasis (HP:0001406)5.08869571
7Microcytic anemia (HP:0001935)5.03633654
8Xanthomatosis (HP:0000991)4.84116828
9Recurrent abscess formation (HP:0002722)4.83849908
10Deep venous thrombosis (HP:0002625)4.75190827
11Abnormality of macrophages (HP:0004311)4.63257013
12Recurrent bacterial skin infections (HP:0005406)4.49787100
13Ketosis (HP:0001946)4.46695726
14Hypoglycemic coma (HP:0001325)4.45818398
15Hypobetalipoproteinemia (HP:0003563)4.43383837
16Hyperammonemia (HP:0001987)4.43128353
17Hyperglycinuria (HP:0003108)4.40898932
18Abnormal hemoglobin (HP:0011902)4.15373669
19Myositis (HP:0100614)4.14070556
20Abnormality of glycine metabolism (HP:0010895)4.05130771
21Abnormality of serine family amino acid metabolism (HP:0010894)4.05130771
22Hyperglycinemia (HP:0002154)4.01326387
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.00663655
24Gout (HP:0001997)3.94545916
25Urticaria (HP:0001025)3.94074364
26Abnormality of fatty-acid metabolism (HP:0004359)3.92774072
27Chronic obstructive pulmonary disease (HP:0006510)3.88327754
28Obstructive lung disease (HP:0006536)3.88327754
29Ketoacidosis (HP:0001993)3.81073531
30Prolonged partial thromboplastin time (HP:0003645)3.73929080
31Recurrent gram-negative bacterial infections (HP:0005420)3.73887080
32Orchitis (HP:0100796)3.71468851
33Hyperlipoproteinemia (HP:0010980)3.67623825
34Stomatitis (HP:0010280)3.61580038
35Hypolipoproteinemia (HP:0010981)3.57248648
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.55925345
37Increased IgE level (HP:0003212)3.51057750
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.50556963
39Elevated erythrocyte sedimentation rate (HP:0003565)3.49583277
40Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.48381512
41Prolonged bleeding time (HP:0003010)3.46679243
42Gastrointestinal infarctions (HP:0005244)3.44486368
43Abnormality of dicarboxylic acid metabolism (HP:0010995)3.44071419
44Dicarboxylic aciduria (HP:0003215)3.44071419
45Abnormality of pyrimidine metabolism (HP:0004353)3.42477701
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36895556
47Petechiae (HP:0000967)3.36088161
48Hypoalphalipoproteinemia (HP:0003233)3.28059934
49Complement deficiency (HP:0004431)3.26682433
50Abnormality of nucleobase metabolism (HP:0010932)3.25269759
51Generalized aminoaciduria (HP:0002909)3.24430884
52Polycythemia (HP:0001901)3.19960618
53Abnormality of purine metabolism (HP:0004352)3.16665788
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.12475676
55Hyperbilirubinemia (HP:0002904)3.11046407
56Proximal tubulopathy (HP:0000114)3.08769312
57Mediastinal lymphadenopathy (HP:0100721)3.04511747
58Late onset (HP:0003584)3.03686875
59Abnormality of methionine metabolism (HP:0010901)3.03294451
60Slow saccadic eye movements (HP:0000514)3.02336006
61Cellulitis (HP:0100658)3.02133758
62Optic neuritis (HP:0100653)2.99555716
63Retrobulbar optic neuritis (HP:0100654)2.99555716
64Toxemia of pregnancy (HP:0100603)2.97734675
65Fat malabsorption (HP:0002630)2.96819908
66Delayed CNS myelination (HP:0002188)2.96331799
67Gastrointestinal inflammation (HP:0004386)2.95670667
68Recurrent fungal infections (HP:0002841)2.95069597
69Lethargy (HP:0001254)2.94624323
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.92666986
71Meningitis (HP:0001287)2.91771496
72Abnormality of the common coagulation pathway (HP:0010990)2.91438878
73Metabolic acidosis (HP:0001942)2.88851447
74Abnormality of the intrinsic pathway (HP:0010989)2.87642774
75Gingivitis (HP:0000230)2.86645517
76Inflammation of the large intestine (HP:0002037)2.85037813
77Abnormality of serum amino acid levels (HP:0003112)2.83459639
78Pustule (HP:0200039)2.82900196
79Recurrent skin infections (HP:0001581)2.81988586
80Joint hemorrhage (HP:0005261)2.75161598
81Epidermoid cyst (HP:0200040)2.71038957
82Nausea (HP:0002018)2.70362673
83Hyperuricemia (HP:0002149)2.70138144
84Increased purine levels (HP:0004368)2.70138144
85Increased serum ferritin (HP:0003281)2.67714514
86Encephalitis (HP:0002383)2.67401806
87Episodic fever (HP:0001954)2.67247201
88Hepatocellular carcinoma (HP:0001402)2.62845232
89Abnormality of complement system (HP:0005339)2.61006341
90Hypoglycemic seizures (HP:0002173)2.59926401
91Cerebral edema (HP:0002181)2.59737560
92Malnutrition (HP:0004395)2.59485629
93Spontaneous hematomas (HP:0007420)2.50600721
94Vomiting (HP:0002013)2.49840336
95Abnormality of urine glucose concentration (HP:0011016)2.49424016
96Glycosuria (HP:0003076)2.49424016
97Anorexia (HP:0002039)2.47031945
98Hypercholesterolemia (HP:0003124)2.46175720
99Epistaxis (HP:0000421)2.45123846
100Gingival bleeding (HP:0000225)2.45121122
101Cholelithiasis (HP:0001081)2.39190979
102Alkalosis (HP:0001948)2.39063416
103Abnormal gallbladder physiology (HP:0012438)2.38987302
104Cholecystitis (HP:0001082)2.38987302
105Hyperinsulinemic hypoglycemia (HP:0000825)2.38058704
106Irritability (HP:0000737)2.37891187
107Vasculitis (HP:0002633)2.36600619
108Abnormal gallbladder morphology (HP:0012437)2.34838558
109Spastic diplegia (HP:0001264)2.34398994
110Myoglobinuria (HP:0002913)2.32277351
111Vascular calcification (HP:0004934)2.31914888
112Abnormal cartilage morphology (HP:0002763)2.30946270
113Osteomyelitis (HP:0002754)2.30244689
114Purpura (HP:0000979)2.27857264
115Increased IgM level (HP:0003496)2.27404800
116Hypertensive crisis (HP:0100735)2.27064913
117Chest pain (HP:0100749)2.25545193
118Keratoconjunctivitis sicca (HP:0001097)2.23775828
119Hepatosplenomegaly (HP:0001433)2.22946599
120Rhabdomyolysis (HP:0003201)2.21067614
121Steatorrhea (HP:0002570)2.20992207
122Pancreatitis (HP:0001733)2.15031944
123Poikilocytosis (HP:0004447)2.13849231
124Hepatic necrosis (HP:0002605)2.13623398
125Neonatal onset (HP:0003623)2.13281101
126Multiple enchondromatosis (HP:0005701)2.12126008
127Brushfield spots (HP:0001088)2.11366958
128Recurrent cutaneous fungal infections (HP:0011370)2.10747034
129Chronic mucocutaneous candidiasis (HP:0002728)2.10747034
130Abnormality of proline metabolism (HP:0010907)2.09351761
131Hydroxyprolinuria (HP:0003080)2.09351761
132Recurrent viral infections (HP:0004429)2.07809440
133Abnormality of reticulocytes (HP:0004312)2.06528090
134Cardiovascular calcification (HP:0011915)2.06019916
135Conjugated hyperbilirubinemia (HP:0002908)2.02384602
136Reticulocytosis (HP:0001923)2.02358260
137Enlarged kidneys (HP:0000105)2.02123635
138Hypertriglyceridemia (HP:0002155)2.00393189
139Keratoconjunctivitis (HP:0001096)2.00034162
140Abnormality of transition element cation homeostasis (HP:0011030)1.97926998
141Hyperphosphaturia (HP:0003109)1.97529666
142Skin nodule (HP:0200036)1.97306904
143Abnormal platelet volume (HP:0011876)1.97072509
144Abnormal enzyme/coenzyme activity (HP:0012379)1.96866107
145Metaphyseal cupping (HP:0003021)1.96551588
146Abnormality of T cell physiology (HP:0011840)1.96528162
147Rickets (HP:0002748)1.95727748
148Opisthotonus (HP:0002179)1.95536468
149Granulocytopenia (HP:0001913)1.95032550
150Ragged-red muscle fibers (HP:0003200)1.94729059
151Cutaneous photosensitivity (HP:0000992)1.94701245
152Lymphopenia (HP:0001888)1.94284268
153Abnormality of the gallbladder (HP:0005264)1.93894751
154Abnormality of the pericardium (HP:0001697)1.93215642
155Increased muscle lipid content (HP:0009058)1.92481224
156Acanthocytosis (HP:0001927)1.92475563
157Colitis (HP:0002583)1.92085235
158Ileus (HP:0002595)1.91000900
159Pallor (HP:0000980)1.90587046
160Abnormality of T cells (HP:0002843)1.88096713
161Symptomatic seizures (HP:0011145)1.87802066
162Abnormality of glycolipid metabolism (HP:0010969)1.87341963
163Abnormality of liposaccharide metabolism (HP:0010968)1.87341963
164Abnormality of glycosphingolipid metabolism (HP:0004343)1.87341963
165Hypergammaglobulinemia (HP:0010702)1.87238232
166Esophageal varix (HP:0002040)1.86916903
167Myocardial infarction (HP:0001658)1.86100005
168Gastrointestinal dysmotility (HP:0002579)1.86001679
169Panhypogammaglobulinemia (HP:0003139)1.84569884
170Nephrolithiasis (HP:0000787)1.84340224
171Hypochromic microcytic anemia (HP:0004840)1.84276167
172Sepsis (HP:0100806)1.83575208
173Insulin resistance (HP:0000855)1.83363032
174Abnormality of iron homeostasis (HP:0011031)1.81807321
175Abnormality of cells of the lymphoid lineage (HP:0012140)1.81700765
176Amyloidosis (HP:0011034)1.81697410
177Nasal polyposis (HP:0100582)1.81480930
178Severe visual impairment (HP:0001141)1.80480486
179Peritonitis (HP:0002586)1.80458668
180Arterial thrombosis (HP:0004420)1.79354692
181Skin ulcer (HP:0200042)1.79344976
182Pathologic fracture (HP:0002756)1.78229446
183Leukocytosis (HP:0001974)1.78040908
184Hypermelanotic macule (HP:0001034)1.76663375
185Splenomegaly (HP:0001744)1.74880983
186IgM deficiency (HP:0002850)1.74856930
187Increased cerebral lipofuscin (HP:0011813)1.73896635
188Glomerulopathy (HP:0100820)1.70567027
189Myopathic facies (HP:0002058)1.69912730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.81295666
2ERN13.49315828
3RIPK43.33635172
4TRIB33.23295962
5MAP4K13.03547105
6PDK32.69443270
7PDK42.69443270
8PKN22.68416019
9TAOK22.59780077
10IRAK42.55769087
11SMG12.48860086
12PRPF4B2.48707702
13EIF2AK12.41942291
14WNK42.37896825
15TESK12.32050615
16TNK22.27814273
17EPHB12.12595149
18FLT32.05894978
19NME21.98158660
20FGFR41.90057967
21SIK11.88300654
22EPHA21.87694933
23NEK11.84201883
24WNK31.84043529
25TESK21.78359860
26CSK1.72231655
27BUB11.69292903
28FES1.63048624
29MAP3K11.58971631
30KDR1.57814931
31WEE11.54809495
32PDK21.54343702
33MAP3K111.54169221
34BLK1.51459109
35SIK31.45834196
36FGR1.45297844
37MAP3K101.41938200
38HCK1.40179280
39KSR21.31937488
40STK38L1.31901433
41MAPKAPK31.28730292
42NEK21.26415340
43MAPK111.25789058
44MAPK151.24009313
45BTK1.23448357
46DYRK1B1.23073805
47STK161.22094607
48PRKD21.22045367
49MAP3K31.18556488
50MST1R1.16428840
51ICK1.16166095
52TTK1.16019218
53SCYL21.14759285
54MAP2K21.14674049
55MAP2K31.09187823
56ABL21.07625927
57JAK31.05658931
58PTK61.03774310
59NEK91.02763713
60PAK41.02346072
61PASK0.99944831
62DYRK30.99373900
63SYK0.95290988
64INSRR0.94072539
65MARK20.92189200
66MARK30.92165599
67PRKD30.91730091
68MAP3K80.91376560
69LRRK20.91375139
70TLK10.88915632
71IKBKE0.88836550
72MET0.87155080
73EIF2AK30.86821975
74EEF2K0.86209675
75PDPK10.85727272
76PTK2B0.84572085
77BRSK20.84007394
78PIK3CG0.82918024
79CDK40.82817204
80RPS6KB20.81931777
81ACVR1B0.81409760
82LYN0.80258698
83CDK190.79262174
84TAOK30.75572633
85HIPK20.72991030
86PDK10.72924169
87ERBB40.72358381
88PIM20.71135023
89AURKA0.70719475
90RPS6KA40.70533073
91PTK20.69353393
92STK380.68256005
93CDK120.66545889
94SIK20.64789266
95IRAK20.64761565
96MTOR0.64719545
97LCK0.64179344
98MAPKAPK20.63997076
99YES10.62682661
100TBK10.60336979
101MAP3K20.59699747
102GRK60.58021003
103ZAP700.58002252
104PINK10.57519431
105CDK70.57305038
106MYLK0.57071814
107PRKG20.56718080
108IRAK30.56681053
109AURKB0.55712215
110CDK60.54109513
111CSF1R0.52691508
112CLK10.52625268
113PLK10.52516969
114BRSK10.52329319
115RPS6KC10.51085370
116RPS6KL10.51085370
117CDC70.49506261
118IKBKB0.48125945
119LATS10.47981700
120STK100.46904218
121RAF10.46215095
122PIM10.45975168
123TYK20.45610275
124LMTK20.45594946
125STK40.44994639
126FRK0.43686995
127MAP2K60.43419598
128PRKCI0.42786887
129RIPK10.42595519
130MAP3K130.41162733
131PRKAA10.40457372
132RPS6KA20.40077624
133STK110.39607646
134SGK30.39321518
135ITK0.39258422
136TAOK10.38703930
137BRAF0.38589181
138JAK20.38179920
139DAPK30.37916401
140MAPK120.37441899
141GSK3A0.36935269
142FYN0.36385029
143MAP3K70.36157986
144RPS6KA60.35831619
145MAP2K10.35826556
146TGFBR10.35709875
147MAP3K50.35405208
148ARAF0.35079880
149TXK0.34013102
150PAK20.33224673
151ERBB20.32958702
152PAK10.32078997
153BMX0.31923110
154MATK0.31599898
155CSNK2A10.30375270
156RET0.28764945
157MAP3K140.28696938
158IRAK10.27906481
159JAK10.27890360

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.13358273
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.04905348
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.89194562
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78805011
5Fatty acid degradation_Homo sapiens_hsa000712.62021766
6Osteoclast differentiation_Homo sapiens_hsa043802.61834280
7Malaria_Homo sapiens_hsa051442.58751043
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56291420
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55738097
10Acute myeloid leukemia_Homo sapiens_hsa052212.55376144
11Nitrogen metabolism_Homo sapiens_hsa009102.42963903
12Tryptophan metabolism_Homo sapiens_hsa003802.36699602
13Propanoate metabolism_Homo sapiens_hsa006402.34455078
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.31762961
15Arginine biosynthesis_Homo sapiens_hsa002202.30379470
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.29853006
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24529186
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.21761569
19B cell receptor signaling pathway_Homo sapiens_hsa046622.15740595
20Leishmaniasis_Homo sapiens_hsa051402.14732969
21Selenocompound metabolism_Homo sapiens_hsa004502.08720645
22Non-small cell lung cancer_Homo sapiens_hsa052232.02115846
23Butanoate metabolism_Homo sapiens_hsa006501.99801839
24Primary immunodeficiency_Homo sapiens_hsa053401.98095561
25Peroxisome_Homo sapiens_hsa041461.97785127
26Pyruvate metabolism_Homo sapiens_hsa006201.95585645
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.95270164
28Chronic myeloid leukemia_Homo sapiens_hsa052201.93356276
29Pancreatic cancer_Homo sapiens_hsa052121.88156837
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85423918
31Fatty acid metabolism_Homo sapiens_hsa012121.81661173
32Carbon metabolism_Homo sapiens_hsa012001.80115974
33Folate biosynthesis_Homo sapiens_hsa007901.76789007
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.75952165
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.73137114
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.72636141
37Biosynthesis of amino acids_Homo sapiens_hsa012301.70173517
38PPAR signaling pathway_Homo sapiens_hsa033201.69442564
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67977110
40Complement and coagulation cascades_Homo sapiens_hsa046101.67671680
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67048236
42Tuberculosis_Homo sapiens_hsa051521.66012507
43African trypanosomiasis_Homo sapiens_hsa051431.63994691
44beta-Alanine metabolism_Homo sapiens_hsa004101.62997677
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.60149566
46Measles_Homo sapiens_hsa051621.59114852
47Sulfur relay system_Homo sapiens_hsa041221.57510437
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55185755
49Chemical carcinogenesis_Homo sapiens_hsa052041.53389767
50Sulfur metabolism_Homo sapiens_hsa009201.53335623
51T cell receptor signaling pathway_Homo sapiens_hsa046601.52369906
52One carbon pool by folate_Homo sapiens_hsa006701.45633605
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.44565681
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.43645030
55Herpes simplex infection_Homo sapiens_hsa051681.43510896
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43381158
57Histidine metabolism_Homo sapiens_hsa003401.43328130
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41053670
59Chemokine signaling pathway_Homo sapiens_hsa040621.41051409
60Fat digestion and absorption_Homo sapiens_hsa049751.38146003
61Phenylalanine metabolism_Homo sapiens_hsa003601.37413954
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37181744
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35364863
64Toxoplasmosis_Homo sapiens_hsa051451.34796473
65VEGF signaling pathway_Homo sapiens_hsa043701.34710258
66NF-kappa B signaling pathway_Homo sapiens_hsa040641.34185170
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32780973
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31648868
69Hepatitis C_Homo sapiens_hsa051601.31464505
70Thyroid cancer_Homo sapiens_hsa052161.30477051
71Leukocyte transendothelial migration_Homo sapiens_hsa046701.30439829
72Apoptosis_Homo sapiens_hsa042101.30116623
73Graft-versus-host disease_Homo sapiens_hsa053321.29442559
74Influenza A_Homo sapiens_hsa051641.28542397
75Shigellosis_Homo sapiens_hsa051311.25496387
76Steroid hormone biosynthesis_Homo sapiens_hsa001401.25335974
77Glutathione metabolism_Homo sapiens_hsa004801.25269868
78Allograft rejection_Homo sapiens_hsa053301.20997293
79Antigen processing and presentation_Homo sapiens_hsa046121.20580128
80Starch and sucrose metabolism_Homo sapiens_hsa005001.20174290
81Caffeine metabolism_Homo sapiens_hsa002321.16532062
82Endometrial cancer_Homo sapiens_hsa052131.16417407
83Hematopoietic cell lineage_Homo sapiens_hsa046401.16252820
84Bile secretion_Homo sapiens_hsa049761.16239964
85Autoimmune thyroid disease_Homo sapiens_hsa053201.15395877
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15304236
87Hepatitis B_Homo sapiens_hsa051611.15042545
88Pentose phosphate pathway_Homo sapiens_hsa000301.14903282
89Tyrosine metabolism_Homo sapiens_hsa003501.14679774
90Arginine and proline metabolism_Homo sapiens_hsa003301.14155300
91Retinol metabolism_Homo sapiens_hsa008301.11620345
92Endocytosis_Homo sapiens_hsa041441.11084345
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08613028
94Viral myocarditis_Homo sapiens_hsa054161.07896806
95Jak-STAT signaling pathway_Homo sapiens_hsa046301.06718214
96Legionellosis_Homo sapiens_hsa051341.06539472
97Renal cell carcinoma_Homo sapiens_hsa052111.06072729
98Phagosome_Homo sapiens_hsa041451.01778185
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01416803
100Epstein-Barr virus infection_Homo sapiens_hsa051690.98612845
101Vitamin B6 metabolism_Homo sapiens_hsa007500.98491911
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96480038
103Notch signaling pathway_Homo sapiens_hsa043300.93876926
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93019502
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92989723
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92945303
107Vitamin digestion and absorption_Homo sapiens_hsa049770.92244138
108Fatty acid elongation_Homo sapiens_hsa000620.90678844
109Fructose and mannose metabolism_Homo sapiens_hsa000510.90030447
110TNF signaling pathway_Homo sapiens_hsa046680.89215818
111Viral carcinogenesis_Homo sapiens_hsa052030.87586705
112Salmonella infection_Homo sapiens_hsa051320.87483270
113Lysine degradation_Homo sapiens_hsa003100.84565260
114HTLV-I infection_Homo sapiens_hsa051660.81657026
115Glycerolipid metabolism_Homo sapiens_hsa005610.81037278
116ABC transporters_Homo sapiens_hsa020100.80100818
117mTOR signaling pathway_Homo sapiens_hsa041500.79977640
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79913124
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.79691873
120Colorectal cancer_Homo sapiens_hsa052100.79563833
121Staphylococcus aureus infection_Homo sapiens_hsa051500.76589394
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76150270
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75294106
124Platelet activation_Homo sapiens_hsa046110.73515863
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73088693
126Galactose metabolism_Homo sapiens_hsa000520.71570417
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.71370544
128Collecting duct acid secretion_Homo sapiens_hsa049660.71105895
129Choline metabolism in cancer_Homo sapiens_hsa052310.70938552
130Lysosome_Homo sapiens_hsa041420.70823098
131Inositol phosphate metabolism_Homo sapiens_hsa005620.69577317
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69140950
133Insulin signaling pathway_Homo sapiens_hsa049100.68750742
134HIF-1 signaling pathway_Homo sapiens_hsa040660.68313553
135Regulation of autophagy_Homo sapiens_hsa041400.67628433
136Prolactin signaling pathway_Homo sapiens_hsa049170.67352301
137Metabolic pathways_Homo sapiens_hsa011000.65737951
138FoxO signaling pathway_Homo sapiens_hsa040680.63941225
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62436954
140Steroid biosynthesis_Homo sapiens_hsa001000.61149961
141Small cell lung cancer_Homo sapiens_hsa052220.60724757
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60722335
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59989409
144DNA replication_Homo sapiens_hsa030300.59380497
145Vibrio cholerae infection_Homo sapiens_hsa051100.58332746
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58039550
147Type I diabetes mellitus_Homo sapiens_hsa049400.56734428
148Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56340258
149Glioma_Homo sapiens_hsa052140.53027372
150ErbB signaling pathway_Homo sapiens_hsa040120.52866882
151Prostate cancer_Homo sapiens_hsa052150.52782696
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.51212299
153Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50264231
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48701090
155Proteasome_Homo sapiens_hsa030500.47879022
156Pyrimidine metabolism_Homo sapiens_hsa002400.47715196
157Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41468492
158Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40482663
159alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37766535
160Fatty acid biosynthesis_Homo sapiens_hsa000610.32753366
161Ribosome_Homo sapiens_hsa030100.32727890
162Parkinsons disease_Homo sapiens_hsa050120.32561631
163Oxidative phosphorylation_Homo sapiens_hsa001900.31976409
164Linoleic acid metabolism_Homo sapiens_hsa005910.29024482
165Glucagon signaling pathway_Homo sapiens_hsa049220.24496815
166Insulin resistance_Homo sapiens_hsa049310.24311803
167Mismatch repair_Homo sapiens_hsa034300.23861168
168Adipocytokine signaling pathway_Homo sapiens_hsa049200.22147414
169Protein export_Homo sapiens_hsa030600.19569560
170Glycosaminoglycan degradation_Homo sapiens_hsa005310.19076481
171Systemic lupus erythematosus_Homo sapiens_hsa053220.18870466
172AMPK signaling pathway_Homo sapiens_hsa041520.18303918
173Other glycan degradation_Homo sapiens_hsa005110.16858784
174Bladder cancer_Homo sapiens_hsa052190.16574317
175Huntingtons disease_Homo sapiens_hsa050160.15830509
176Renin-angiotensin system_Homo sapiens_hsa046140.15446428
177Base excision repair_Homo sapiens_hsa034100.13954892
178Protein digestion and absorption_Homo sapiens_hsa049740.11698615
179Glycerophospholipid metabolism_Homo sapiens_hsa005640.11409496
180Central carbon metabolism in cancer_Homo sapiens_hsa052300.09893597
181Arachidonic acid metabolism_Homo sapiens_hsa005900.06136389
182RNA transport_Homo sapiens_hsa030130.06111756

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »