ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	snRNA transcription (GO:0009301)	7.49190473
2	centriole replication (GO:0007099)	5.56250678
3	peptidyl-histidine modification (GO:0018202)	5.40686269
4	keratinocyte development (GO:0003334)	5.23082112
5	positive regulation of protein sumoylation (GO:0033235)	4.97288626
6	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	4.67492284
7	fibroblast migration (GO:0010761)	4.49473228
8	inner ear receptor stereocilium organization (GO:0060122)	4.46885037
9	synaptic transmission, dopaminergic (GO:0001963)	4.46737339
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.40887457
11	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	4.29021075
12	regulation of translation, ncRNA-mediated (GO:0045974)	4.06079416
13	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.06079416
14	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.06079416
15	replication fork processing (GO:0031297)	3.90596860
16	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	3.85755770
17	negative regulation of mast cell activation (GO:0033004)	3.83704038
18	establishment of nucleus localization (GO:0040023)	3.77078476
19	auditory receptor cell stereocilium organization (GO:0060088)	3.76808413
20	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	3.72601322
21	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	3.70915235
22	hair follicle development (GO:0001942)	3.70289336
23	indole-containing compound catabolic process (GO:0042436)	3.68148454
24	indolalkylamine catabolic process (GO:0046218)	3.68148454
25	tryptophan catabolic process (GO:0006569)	3.68148454
26	regulation of action potential (GO:0098900)	3.67513182
27	centriole assembly (GO:0098534)	3.59122436
28	regulation of clathrin-mediated endocytosis (GO:2000369)	3.57748628
29	cell wall macromolecule catabolic process (GO:0016998)	3.54540153
30	acrosome assembly (GO:0001675)	3.52777531
31	centrosome localization (GO:0051642)	3.49276544
32	negative regulation of keratinocyte proliferation (GO:0010839)	3.48445644
33	regulation of DNA endoreduplication (GO:0032875)	3.42237051
34	positive regulation of DNA-templated transcription, elongation (GO:0032786)	3.41804186
35	forebrain neuron differentiation (GO:0021879)	3.37234431
36	kidney morphogenesis (GO:0060993)	3.36237047
37	nucleus localization (GO:0051647)	3.36020161
38	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	3.33415087
39	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	3.30882851
40	regulation of cAMP-mediated signaling (GO:0043949)	3.29396670
41	establishment of skin barrier (GO:0061436)	3.26812912
42	regulation of protein sumoylation (GO:0033233)	3.26113453
43	brain morphogenesis (GO:0048854)	3.25795415
44	motile cilium assembly (GO:0044458)	3.21659590
45	microtubule depolymerization (GO:0007019)	3.21449307
46	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.20527449
47	tryptophan metabolic process (GO:0006568)	3.20183313
48	anterior/posterior axis specification, embryo (GO:0008595)	3.19990933
49	pituitary gland development (GO:0021983)	3.19375041
50	otic vesicle formation (GO:0030916)	3.18504221
51	negative regulation of DNA repair (GO:0045738)	3.04736192
52	nonmotile primary cilium assembly (GO:0035058)	3.01664506
53	ventricular septum development (GO:0003281)	2.99787615
54	regulation of telomere maintenance (GO:0032204)	2.99134076
55	indolalkylamine metabolic process (GO:0006586)	2.99080852
56	monoubiquitinated protein deubiquitination (GO:0035520)	2.97835471
57	cell wall macromolecule metabolic process (GO:0044036)	2.93584888
58	regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)	2.93386165
59	DNA demethylation (GO:0080111)	2.92368458
60	mitochondrial DNA replication (GO:0006264)	2.91833249
61	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.91375905
62	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.90691270
63	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.89612588
64	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.87016859
65	oocyte development (GO:0048599)	2.86829799
66	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.85313043
67	RNA localization (GO:0006403)	2.85135401
68	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.84888662
69	acrosome reaction (GO:0007340)	2.84870638
70	cellular protein complex localization (GO:0034629)	2.84658158
71	negative regulation of signal transduction by p53 class mediator (GO:1901797)	2.83428326
72	prenylation (GO:0097354)	2.79649336
73	protein prenylation (GO:0018342)	2.79649336
74	detection of light stimulus involved in sensory perception (GO:0050962)	2.78272774
75	detection of light stimulus involved in visual perception (GO:0050908)	2.78272774
76	positive regulation of male gonad development (GO:2000020)	2.75271167
77	telomere maintenance via telomerase (GO:0007004)	2.75037516
78	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.74707801
79	radial glial cell differentiation (GO:0060019)	2.72554097
80	heart field specification (GO:0003128)	2.72338533
81	secondary heart field specification (GO:0003139)	2.72338533
82	limb bud formation (GO:0060174)	2.70646701
83	regulation of DNA-templated transcription, elongation (GO:0032784)	2.69250167
84	regulation of female gonad development (GO:2000194)	2.68611750
85	parental behavior (GO:0060746)	2.67823216
86	molting cycle process (GO:0022404)	2.67107790
87	hair cycle process (GO:0022405)	2.67107790
88	regulation of male gonad development (GO:2000018)	2.66244565
89	positive regulation of interleukin-1 secretion (GO:0050716)	2.66035410
90	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.65708904
91	limb development (GO:0060173)	2.65356255
92	appendage development (GO:0048736)	2.65356255
93	peristalsis (GO:0030432)	2.63631729
94	microtubule polymerization or depolymerization (GO:0031109)	2.63273630
95	rRNA modification (GO:0000154)	2.63129038
96	nuclear pore complex assembly (GO:0051292)	2.62691606
97	positive regulation of neurological system process (GO:0031646)	2.62413131
98	intra-S DNA damage checkpoint (GO:0031573)	2.61458329
99	myelin assembly (GO:0032288)	2.59712409
100	base-excision repair, AP site formation (GO:0006285)	2.59625382

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.91342017
2	VDR_22108803_ChIP-Seq_LS180_Human	4.36405969
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.94976374
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.86996742
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.76988902
6	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.73960218
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.69224301
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.38528430
9	FUS_26573619_Chip-Seq_HEK293_Human	2.31149206
10	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.17195251
11	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.12247678
12	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.07775611
13	CBP_20019798_ChIP-Seq_JUKART_Human	2.07775611
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.07676906
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.07261712
16	IRF1_19129219_ChIP-ChIP_H3396_Human	2.06755069
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.99133364
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.96466261
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.90697265
20	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.90277243
21	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.86429234
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.84626566
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81250824
24	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80732385
25	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.80732385
26	P300_19829295_ChIP-Seq_ESCs_Human	1.78802129
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.76950008
28	RXR_22108803_ChIP-Seq_LS180_Human	1.71784851
29	EWS_26573619_Chip-Seq_HEK293_Human	1.71060636
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.70250256
31	GATA1_22025678_ChIP-Seq_K562_Human	1.68261961
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.67486371
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.62254471
34	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.60619110
35	TCF4_22108803_ChIP-Seq_LS180_Human	1.59443615
36	AHR_22903824_ChIP-Seq_MCF-7_Human	1.55884858
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.51993778
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51422359
39	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.48262751
40	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.47822651
41	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.46702751
42	TBL1_22424771_ChIP-Seq_293T_Human	1.44603683
43	ETV1_20927104_ChIP-Seq_GIST48_Human	1.44491736
44	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.42114801
45	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.41124762
46	PHF8_20622853_ChIP-Seq_HELA_Human	1.40734270
47	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.36947069
48	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.36784138
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.34809644
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33493820
51	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.30421298
52	TCF4_23295773_ChIP-Seq_U87_Human	1.28954920
53	NFYB_21822215_ChIP-Seq_K562_Human	1.28339240
54	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.27900215
55	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.25784902
56	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.25640171
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24736179
58	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.24652692
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24462529
60	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.22929096
61	STAT3_23295773_ChIP-Seq_U87_Human	1.21719691
62	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.21712235
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19981841
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18618749
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18162183
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.17920977
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.17408028
68	NFYA_21822215_ChIP-Seq_K562_Human	1.17088658
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14896705
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14424649
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13547333
72	MYC_18940864_ChIP-ChIP_HL60_Human	1.13057192
73	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.12765704
74	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.12028293
75	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.11846169
76	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.08564086
77	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.08204496
78	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.07067285
79	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.06566937
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.05937215
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02206094
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02003794
83	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.01935073
84	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.00679282
85	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.00002764
86	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.99041194
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98745298
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98745298
89	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.98725943
90	RBPJ_21746931_ChIP-Seq_IB4_Human	0.98704490
91	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98160711
92	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.97351105
93	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.96322898
94	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.95105748
95	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.94762473
96	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.94698111
97	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.93346911
98	E2F7_22180533_ChIP-Seq_HELA_Human	0.92728347
99	BRD4_25478319_ChIP-Seq_HGPS_Human	0.92265272
100	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92029873

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	8.85492027
2	MP0005408_hypopigmentation	4.45494876
3	MP0006292_abnormal_olfactory_placode	4.18338671
4	MP0000427_abnormal_hair_cycle	3.76053967
5	MP0002089_abnormal_postnatal_growth/wei	3.66613286
6	MP0000383_abnormal_hair_follicle	3.45298749
7	MP0000579_abnormal_nail_morphology	3.42422033
8	MP0001661_extended_life_span	3.11747958
9	MP0003950_abnormal_plasma_membrane	2.82794953
10	MP0003890_abnormal_embryonic-extraembry	2.65985374
11	MP0002102_abnormal_ear_morphology	2.42694037
12	MP0008057_abnormal_DNA_replication	2.32746602
13	MP0000631_abnormal_neuroendocrine_gland	2.17392338
14	MP0002098_abnormal_vibrissa_morphology	2.08282972
15	MP0005670_abnormal_white_adipose	2.06834802
16	MP0010678_abnormal_skin_adnexa	2.02391832
17	MP0008058_abnormal_DNA_repair	1.90693791
18	MP0005275_abnormal_skin_tensile	1.85940964
19	MP0005084_abnormal_gallbladder_morpholo	1.85191219
20	MP0005551_abnormal_eye_electrophysiolog	1.63160240
21	MP0004808_abnormal_hematopoietic_stem	1.61152791
22	MP0001293_anophthalmia	1.49925916
23	MP0005083_abnormal_biliary_tract	1.32848835
24	MP0002697_abnormal_eye_size	1.32584814
25	MP0002837_dystrophic_cardiac_calcinosis	1.30787448
26	MP0004264_abnormal_extraembryonic_tissu	1.30259172
27	MP0004742_abnormal_vestibular_system	1.30171150
28	MP0003943_abnormal_hepatobiliary_system	1.28133004
29	MP0002282_abnormal_trachea_morphology	1.27132066
30	MP0010094_abnormal_chromosome_stability	1.22856650
31	MP0009703_decreased_birth_body	1.22783585
32	MP0005075_abnormal_melanosome_morpholog	1.20379631
33	MP0003183_abnormal_peptide_metabolism	1.16659887
34	MP0002638_abnormal_pupillary_reflex	1.15878708
35	MP0000647_abnormal_sebaceous_gland	1.12176268
36	MP0005646_abnormal_pituitary_gland	1.10294423
37	MP0001188_hyperpigmentation	1.09390669
38	MP0000639_abnormal_adrenal_gland	1.09260057
39	MP0010030_abnormal_orbit_morphology	1.08091495
40	MP0003077_abnormal_cell_cycle	1.06886243
41	MP0001286_abnormal_eye_development	1.01616504
42	MP0003786_premature_aging	1.00703847
43	MP0003567_abnormal_fetal_cardiomyocyte	1.00266436
44	MP0001986_abnormal_taste_sensitivity	0.98956528
45	MP0001697_abnormal_embryo_size	0.98099645
46	MP0003718_maternal_effect	0.94973101
47	MP0003936_abnormal_reproductive_system	0.94373908
48	MP0002928_abnormal_bile_duct	0.90917272
49	MP0004043_abnormal_pH_regulation	0.90089708
50	MP0005253_abnormal_eye_physiology	0.89371217
51	MP0008961_abnormal_basal_metabolism	0.88893573
52	MP0004381_abnormal_hair_follicle	0.88158290
53	MP0008995_early_reproductive_senescence	0.84140949
54	MP0002653_abnormal_ependyma_morphology	0.83124433
55	MP0000377_abnormal_hair_follicle	0.82764415
56	MP0005410_abnormal_fertilization	0.82251818
57	MP0002095_abnormal_skin_pigmentation	0.82066350
58	MP0000367_abnormal_coat/_hair	0.80429047
59	MP0002075_abnormal_coat/hair_pigmentati	0.80084583
60	MP0001486_abnormal_startle_reflex	0.78733496
61	MP0003787_abnormal_imprinting	0.78718731
62	MP0002088_abnormal_embryonic_growth/wei	0.77526556
63	MP0005448_abnormal_energy_balance	0.74631457
64	MP0002938_white_spotting	0.74469480
65	MP0001186_pigmentation_phenotype	0.74053227
66	MP0000778_abnormal_nervous_system	0.72807231
67	MP0000350_abnormal_cell_proliferation	0.71845908
68	MP0005195_abnormal_posterior_eye	0.69214962
69	MP0003693_abnormal_embryo_hatching	0.68008336
70	MP0004957_abnormal_blastocyst_morpholog	0.66207518
71	MP0001929_abnormal_gametogenesis	0.65216755
72	MP0001672_abnormal_embryogenesis/_devel	0.65083674
73	MP0005380_embryogenesis_phenotype	0.65083674
74	MP0002752_abnormal_somatic_nervous	0.63772250
75	MP0003984_embryonic_growth_retardation	0.63551500
76	MP0000534_abnormal_ureter_morphology	0.62844536
77	MP0001216_abnormal_epidermal_layer	0.62187464
78	MP0005076_abnormal_cell_differentiation	0.61812955
79	MP0003045_fibrosis	0.60862874
80	MP0003698_abnormal_male_reproductive	0.60814707
81	MP0001666_abnormal_nutrient_absorption	0.60739137
82	MP0001191_abnormal_skin_condition	0.59757761
83	MP0005386_behavior/neurological_phenoty	0.58736709
84	MP0004924_abnormal_behavior	0.58736709
85	MP0002234_abnormal_pharynx_morphology	0.58635252
86	MP0005391_vision/eye_phenotype	0.58586168
87	MP0005171_absent_coat_pigmentation	0.57465073
88	MP0008877_abnormal_DNA_methylation	0.56032862
89	MP0005395_other_phenotype	0.55188152
90	MP0004084_abnormal_cardiac_muscle	0.55121508
91	MP0001119_abnormal_female_reproductive	0.52267878
92	MP0000627_abnormal_mammary_gland	0.52255067
93	MP0001919_abnormal_reproductive_system	0.50983082
94	MP0006072_abnormal_retinal_apoptosis	0.50740159
95	MP0002084_abnormal_developmental_patter	0.50691125
96	MP0003195_calcinosis	0.50032308
97	MP0003011_delayed_dark_adaptation	0.49917012
98	MP0005389_reproductive_system_phenotype	0.49737109
99	MP0003111_abnormal_nucleus_morphology	0.49638511
100	MP0002735_abnormal_chemical_nociception	0.49323727

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	5.41997800
2	Follicular hyperkeratosis (HP:0007502)	5.08972629
3	Sparse lateral eyebrow (HP:0005338)	4.26663119
4	Congenital, generalized hypertrichosis (HP:0004540)	3.85410246
5	Tented upper lip vermilion (HP:0010804)	3.51773734
6	Volvulus (HP:0002580)	3.51247894
7	Concave nail (HP:0001598)	3.41647399
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.36561074
9	Abnormality of hair growth rate (HP:0011363)	3.36373200
10	Slow-growing hair (HP:0002217)	3.36373200
11	Decreased central vision (HP:0007663)	3.31563768
12	Adrenal hypoplasia (HP:0000835)	3.25791186
13	Cerebellar dysplasia (HP:0007033)	3.20391028
14	Congenital stationary night blindness (HP:0007642)	3.04155671
15	Methylmalonic acidemia (HP:0002912)	2.89234777
16	Intrahepatic cholestasis (HP:0001406)	2.88330391
17	Increased number of teeth (HP:0011069)	2.87935205
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.86566607
19	Febrile seizures (HP:0002373)	2.85365702
20	Birth length less than 3rd percentile (HP:0003561)	2.81208133
21	Pendular nystagmus (HP:0012043)	2.80847665
22	True hermaphroditism (HP:0010459)	2.78121048
23	Sparse eyelashes (HP:0000653)	2.68697067
24	Abnormal hair laboratory examination (HP:0003328)	2.68558204
25	Type II lissencephaly (HP:0007260)	2.66185596
26	Dyschromatopsia (HP:0007641)	2.56941492
27	Genetic anticipation (HP:0003743)	2.53471692
28	Woolly hair (HP:0002224)	2.53093451
29	Attenuation of retinal blood vessels (HP:0007843)	2.52911384
30	Bony spicule pigmentary retinopathy (HP:0007737)	2.46152650
31	Molar tooth sign on MRI (HP:0002419)	2.44156898
32	Abnormality of midbrain morphology (HP:0002418)	2.44156898
33	Hypoplasia of the pons (HP:0012110)	2.41554398
34	Medial flaring of the eyebrow (HP:0010747)	2.39489352
35	Pancreatic cysts (HP:0001737)	2.33988016
36	Abnormality of the pons (HP:0007361)	2.33702157
37	Cone-rod dystrophy (HP:0000548)	2.31094045
38	Muscular dystrophy (HP:0003560)	2.30982207
39	Abnormal number of erythroid precursors (HP:0012131)	2.30031298
40	Abnormality of the preputium (HP:0100587)	2.27897042
41	Posterior subcapsular cataract (HP:0007787)	2.27132247
42	Infantile muscular hypotonia (HP:0008947)	2.27059820
43	Small hand (HP:0200055)	2.26039752
44	Right ventricular cardiomyopathy (HP:0011663)	2.22446285
45	Limb hypertonia (HP:0002509)	2.22330838
46	Dyskinesia (HP:0100660)	2.21574439
47	Progressive cerebellar ataxia (HP:0002073)	2.20894917
48	Astigmatism (HP:0000483)	2.19614421
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.18845058
50	Absent/shortened dynein arms (HP:0200106)	2.18845058
51	Asymmetric septal hypertrophy (HP:0001670)	2.16173356
52	Proximal amyotrophy (HP:0007126)	2.14510100
53	Congenital primary aphakia (HP:0007707)	2.14374810
54	Porencephaly (HP:0002132)	2.13277489
55	Gait imbalance (HP:0002141)	2.11146417
56	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.11017324
57	Sensory axonal neuropathy (HP:0003390)	2.10653821
58	Conjugated hyperbilirubinemia (HP:0002908)	2.10207639
59	Flat cornea (HP:0007720)	2.09888485
60	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.08336655
61	Abnormality of chromosome stability (HP:0003220)	2.01876578
62	Curly hair (HP:0002212)	2.01520558
63	Tubulointerstitial nephritis (HP:0001970)	2.01136584
64	Acute myeloid leukemia (HP:0004808)	1.96628161
65	Pigmentary retinal degeneration (HP:0001146)	1.95690090
66	Shoulder girdle muscle weakness (HP:0003547)	1.94538603
67	Severe muscular hypotonia (HP:0006829)	1.94287062
68	Pelvic girdle muscle weakness (HP:0003749)	1.93657328
69	Calf muscle hypertrophy (HP:0008981)	1.93232739
70	Thin upper lip vermilion (HP:0000219)	1.92760719
71	Hyperglycinuria (HP:0003108)	1.91904314
72	Smooth philtrum (HP:0000319)	1.90391046
73	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.89651864
74	Tubular atrophy (HP:0000092)	1.89411694
75	Sex reversal (HP:0012245)	1.87248305
76	Abnormal sex determination (HP:0012244)	1.87248305
77	Methylmalonic aciduria (HP:0012120)	1.85756822
78	Hyperglycinemia (HP:0002154)	1.85002186
79	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.84639011
80	Abnormality of the carotid arteries (HP:0005344)	1.83904814
81	Lip pit (HP:0100267)	1.83552906
82	Gaze-evoked nystagmus (HP:0000640)	1.78916017
83	Long clavicles (HP:0000890)	1.78802618
84	Acute lymphatic leukemia (HP:0006721)	1.78038930
85	Abnormality of homocysteine metabolism (HP:0010919)	1.77867439
86	Homocystinuria (HP:0002156)	1.77867439
87	Nephrogenic diabetes insipidus (HP:0009806)	1.77792639
88	Deep philtrum (HP:0002002)	1.76652845
89	Microvesicular hepatic steatosis (HP:0001414)	1.76476339
90	Thickened nuchal skin fold (HP:0000474)	1.75627648
91	Mucopolysacchariduria (HP:0008155)	1.75473428
92	Urinary glycosaminoglycan excretion (HP:0003541)	1.75473428
93	Clubbing of toes (HP:0100760)	1.75455309
94	Abnormality of macular pigmentation (HP:0008002)	1.74815002
95	Meningocele (HP:0002435)	1.73936790
96	Microretrognathia (HP:0000308)	1.72407847
97	Nasal speech (HP:0001611)	1.71767925
98	Abnormality of vitamin metabolism (HP:0100508)	1.70553692
99	Abnormality of the hip-girdle musculature (HP:0001445)	1.70408573
100	Abnormality of the musculature of the pelvis (HP:0001469)	1.70408573

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	4.09361524
2	MAPK15	3.99170433
3	MAP3K12	3.80958004
4	AKT3	3.50025423
5	GRK1	3.25968206
6	FRK	2.92927389
7	MAP2K4	2.79314707
8	IRAK2	2.57206664
9	TAOK3	2.40555039
10	EPHA2	2.31767818
11	BRSK2	2.29454899
12	MAP2K3	2.27362112
13	MAP3K10	2.14437413
14	PBK	2.13495201
15	WEE1	2.06555405
16	IRAK1	2.06072585
17	VRK2	2.04992494
18	MKNK2	2.04344881
19	NLK	1.93546088
20	VRK1	1.93149811
21	MST4	1.77185832
22	NME1	1.75389061
23	ACVR1B	1.74539864
24	DYRK1B	1.58222928
25	MAP2K6	1.55850798
26	CSNK1G1	1.53999513
27	TLK1	1.34685812
28	WNK3	1.31008689
29	MAP3K4	1.30419557
30	ZAK	1.20921127
31	NUAK1	1.14417055
32	CSNK1A1L	1.12858331
33	PNCK	1.04244633
34	SRPK1	1.02801261
35	BMPR1B	1.00688542
36	CDK19	0.89728174
37	BRD4	0.87169580
38	OXSR1	0.83492937
39	WNK1	0.82703309
40	STK38L	0.79681285
41	DYRK1A	0.79325914
42	CDC7	0.78674790
43	CSNK1G3	0.77763869
44	FGFR1	0.77727617
45	TRIM28	0.77329053
46	PDK2	0.77163361
47	INSRR	0.77018554
48	EIF2AK1	0.76903023
49	MKNK1	0.76860203
50	TAF1	0.75128346
51	STK38	0.74807772
52	PRKCE	0.73426300
53	AURKA	0.71187476
54	CSNK1E	0.68585613
55	TSSK6	0.65954540
56	EPHA4	0.64346485
57	MINK1	0.63400089
58	ADRBK1	0.62747361
59	WNK4	0.62613032
60	LATS1	0.62303726
61	MAP3K2	0.61652375
62	PRKAA1	0.60607401
63	DMPK	0.59290229
64	CDK7	0.59117052
65	CSNK1G2	0.58605920
66	CHEK2	0.57141047
67	AURKB	0.56891057
68	ADRBK2	0.54152555
69	MAP3K9	0.53922158
70	MST1R	0.53391814
71	TGFBR1	0.52631671
72	PLK4	0.52007802
73	TNK2	0.48871728
74	PRKACB	0.45769878
75	ATM	0.44959817
76	BCR	0.44566656
77	EPHA3	0.44359234
78	CAMK1D	0.43794574
79	SGK2	0.43652385
80	CDK2	0.41672551
81	PLK3	0.41630008
82	DYRK3	0.41271892
83	PHKG1	0.40436510
84	PHKG2	0.40436510
85	MAP3K5	0.39658900
86	MAP4K2	0.38153491
87	MAP3K11	0.36700858
88	CSNK1D	0.36647477
89	CAMK1G	0.35046567
90	GSK3B	0.33809521
91	PRKCI	0.33507178
92	ATR	0.33351024
93	MAPK13	0.32927874
94	CDK1	0.31498409
95	PRKCH	0.30500340
96	CHEK1	0.30415674
97	PAK2	0.29731969
98	SGK1	0.29584829
99	CSNK1A1	0.29328567
100	NEK2	0.27751512

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.68854520
2	Phototransduction_Homo sapiens_hsa04744	3.41650728
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.78847774
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.47853882
5	Propanoate metabolism_Homo sapiens_hsa00640	2.46040825
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.37559112
7	RNA polymerase_Homo sapiens_hsa03020	2.19401309
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.17778259
9	Taste transduction_Homo sapiens_hsa04742	2.07410047
10	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.98166502
11	Nitrogen metabolism_Homo sapiens_hsa00910	1.94201320
12	RNA degradation_Homo sapiens_hsa03018	1.91648035
13	Spliceosome_Homo sapiens_hsa03040	1.90590636
14	Caffeine metabolism_Homo sapiens_hsa00232	1.80395922
15	RNA transport_Homo sapiens_hsa03013	1.75059779
16	Basal transcription factors_Homo sapiens_hsa03022	1.72314792
17	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.67453277
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.67018756
19	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.66951460
20	Thyroid cancer_Homo sapiens_hsa05216	1.61312705
21	Nicotine addiction_Homo sapiens_hsa05033	1.56166174
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.55950870
23	Butanoate metabolism_Homo sapiens_hsa00650	1.47473759
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.44907400
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.43290527
26	Homologous recombination_Homo sapiens_hsa03440	1.42216071
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.41977534
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.36036722
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.29467005
30	Notch signaling pathway_Homo sapiens_hsa04330	1.22580033
31	beta-Alanine metabolism_Homo sapiens_hsa00410	1.21407558
32	Lysine degradation_Homo sapiens_hsa00310	1.20389703
33	mRNA surveillance pathway_Homo sapiens_hsa03015	1.19930213
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.19290880
35	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.18451186
36	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.14361565
37	Linoleic acid metabolism_Homo sapiens_hsa00591	1.07259552
38	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.00595936
39	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98966060
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.97062410
41	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.96634503
42	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.94428595
43	TNF signaling pathway_Homo sapiens_hsa04668	0.89682330
44	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.85912420
45	Cocaine addiction_Homo sapiens_hsa05030	0.85480245
46	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.80806249
47	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.79407216
48	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.75603210
49	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.75268163
50	Purine metabolism_Homo sapiens_hsa00230	0.75089774
51	Peroxisome_Homo sapiens_hsa04146	0.73296447
52	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.71641468
53	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.70632190
54	Olfactory transduction_Homo sapiens_hsa04740	0.69879368
55	Huntingtons disease_Homo sapiens_hsa05016	0.69570109
56	Basal cell carcinoma_Homo sapiens_hsa05217	0.68479649
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67254987
58	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.66719785
59	Long-term depression_Homo sapiens_hsa04730	0.63929711
60	Retinol metabolism_Homo sapiens_hsa00830	0.63516294
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.63311505
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.62364505
63	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62014420
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.61614202
65	Proteasome_Homo sapiens_hsa03050	0.61409144
66	Hippo signaling pathway_Homo sapiens_hsa04390	0.61267399
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.58707003
68	Prostate cancer_Homo sapiens_hsa05215	0.58618386
69	Ribosome_Homo sapiens_hsa03010	0.56702455
70	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.56428024
71	Base excision repair_Homo sapiens_hsa03410	0.56353034
72	Steroid biosynthesis_Homo sapiens_hsa00100	0.56178829
73	DNA replication_Homo sapiens_hsa03030	0.52309441
74	Prolactin signaling pathway_Homo sapiens_hsa04917	0.49548224
75	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.48177616
76	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.47308045
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47154962
78	ABC transporters_Homo sapiens_hsa02010	0.46886608
79	Estrogen signaling pathway_Homo sapiens_hsa04915	0.46333703
80	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44797143
81	Axon guidance_Homo sapiens_hsa04360	0.44123131
82	FoxO signaling pathway_Homo sapiens_hsa04068	0.42372437
83	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.41364574
84	Insulin secretion_Homo sapiens_hsa04911	0.41017569
85	Ether lipid metabolism_Homo sapiens_hsa00565	0.40330834
86	MicroRNAs in cancer_Homo sapiens_hsa05206	0.39462667
87	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.39385478
88	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.38663774
89	Tight junction_Homo sapiens_hsa04530	0.38045691
90	Melanogenesis_Homo sapiens_hsa04916	0.36866694
91	Cell cycle_Homo sapiens_hsa04110	0.36660660
92	Influenza A_Homo sapiens_hsa05164	0.36609294
93	Colorectal cancer_Homo sapiens_hsa05210	0.35516567
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35295623
95	Amphetamine addiction_Homo sapiens_hsa05031	0.35112433
96	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.34165118
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33819197
98	Serotonergic synapse_Homo sapiens_hsa04726	0.33228313
99	Hepatitis B_Homo sapiens_hsa05161	0.33021076
100	GnRH signaling pathway_Homo sapiens_hsa04912	0.32320765

SLC25A39P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »