ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	9.34088271
2	male meiosis (GO:0007140)	8.63017917
3	male meiosis I (GO:0007141)	8.16327455
4	chromosome organization involved in meiosis (GO:0070192)	8.07290023
5	DNA methylation involved in gamete generation (GO:0043046)	7.65024996
6	synaptonemal complex assembly (GO:0007130)	6.71901859
7	regulation of meiosis I (GO:0060631)	6.63439775
8	meiosis I (GO:0007127)	6.55703778
9	meiotic nuclear division (GO:0007126)	6.51730894
10	synaptonemal complex organization (GO:0070193)	6.10079181
11	histone H3-K9 demethylation (GO:0033169)	5.45806568
12	DNA synthesis involved in DNA repair (GO:0000731)	5.42501847
13	regulation of DNA endoreduplication (GO:0032875)	5.39323652
14	centriole replication (GO:0007099)	5.09510440
15	meiotic cell cycle process (GO:1903046)	5.02754190
16	epithelial cilium movement (GO:0003351)	4.70632429
17	base-excision repair, AP site formation (GO:0006285)	4.68889772
18	meiotic chromosome segregation (GO:0045132)	4.67076423
19	spermatid development (GO:0007286)	4.40798959
20	centriole assembly (GO:0098534)	4.39348202
21	sister chromatid cohesion (GO:0007062)	4.31915182
22	histone exchange (GO:0043486)	4.26538589
23	proteasome assembly (GO:0043248)	4.22422036
24	axonemal dynein complex assembly (GO:0070286)	4.13960449
25	cilium or flagellum-dependent cell motility (GO:0001539)	4.03675328
26	cilium movement (GO:0003341)	3.99618568
27	regulation of histone H3-K9 methylation (GO:0051570)	3.96537521
28	reciprocal meiotic recombination (GO:0007131)	3.94463499
29	reciprocal DNA recombination (GO:0035825)	3.94463499
30	gene silencing by RNA (GO:0031047)	3.91065297
31	binding of sperm to zona pellucida (GO:0007339)	3.90353890
32	motile cilium assembly (GO:0044458)	3.84206453
33	histone H3-K36 demethylation (GO:0070544)	3.79009647
34	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.77456570
35	resolution of meiotic recombination intermediates (GO:0000712)	3.76945685
36	negative regulation of gene silencing (GO:0060969)	3.73392430
37	acrosome reaction (GO:0007340)	3.71034848
38	female gamete generation (GO:0007292)	3.66328853
39	chromatin remodeling at centromere (GO:0031055)	3.51353241
40	sperm motility (GO:0030317)	3.42143345
41	regulation of transcription from RNA polymerase I promoter (GO:0006356)	3.39921999
42	CENP-A containing nucleosome assembly (GO:0034080)	3.37915572
43	sex differentiation (GO:0007548)	3.36910862
44	DNA replication-dependent nucleosome assembly (GO:0006335)	3.35961472
45	DNA replication-dependent nucleosome organization (GO:0034723)	3.35961472
46	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.35640616
47	histone H2A acetylation (GO:0043968)	3.30783688
48	positive regulation of meiosis (GO:0045836)	3.28422901
49	sperm-egg recognition (GO:0035036)	3.27329603
50	pyrimidine nucleotide catabolic process (GO:0006244)	3.27204885
51	striatum development (GO:0021756)	3.26573031
52	positive regulation of meiotic cell cycle (GO:0051446)	3.21622181
53	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.13472412
54	DNA double-strand break processing (GO:0000729)	3.11754974
55	regulation of centriole replication (GO:0046599)	3.08123433
56	germ cell development (GO:0007281)	3.06286295
57	somite rostral/caudal axis specification (GO:0032525)	3.02838596
58	intraciliary transport (GO:0042073)	3.02435828
59	chaperone-mediated protein transport (GO:0072321)	2.99157293
60	fertilization (GO:0009566)	2.94068723
61	microtubule depolymerization (GO:0007019)	2.93480122
62	regulation of mesoderm development (GO:2000380)	2.92699600
63	meiotic cell cycle (GO:0051321)	2.92587401
64	anterior/posterior axis specification, embryo (GO:0008595)	2.79380121
65	genitalia morphogenesis (GO:0035112)	2.77057946
66	DNA methylation (GO:0006306)	2.75117649
67	DNA alkylation (GO:0006305)	2.75117649
68	spermatogenesis (GO:0007283)	2.73904515
69	male gamete generation (GO:0048232)	2.73713430
70	cellular ketone body metabolic process (GO:0046950)	2.72943782
71	gamete generation (GO:0007276)	2.71220955
72	cell migration involved in gastrulation (GO:0042074)	2.68298917
73	mismatch repair (GO:0006298)	2.66798222
74	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.66752970
75	chromosome organization (GO:0051276)	2.65830448
76	indole-containing compound catabolic process (GO:0042436)	2.65644064
77	indolalkylamine catabolic process (GO:0046218)	2.65644064
78	tryptophan catabolic process (GO:0006569)	2.65644064
79	histone H4-K12 acetylation (GO:0043983)	2.63066493
80	cilium assembly (GO:0042384)	2.62822148
81	regulation of mitotic spindle checkpoint (GO:1903504)	2.60855739
82	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.60855739
83	positive regulation of response to oxidative stress (GO:1902884)	2.60284965
84	positive regulation of cellular response to oxidative stress (GO:1900409)	2.60284965
85	cilium organization (GO:0044782)	2.59985250
86	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.59661599
87	DNA replication-independent nucleosome organization (GO:0034724)	2.58299657
88	DNA replication-independent nucleosome assembly (GO:0006336)	2.58299657
89	nuclear division (GO:0000280)	2.56149605
90	protein localization to cilium (GO:0061512)	2.55875932
91	regulation of meiotic cell cycle (GO:0051445)	2.55825001
92	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.55062220
93	regulation of posttranscriptional gene silencing (GO:0060147)	2.53842705
94	regulation of gene silencing by miRNA (GO:0060964)	2.53842705
95	regulation of gene silencing by RNA (GO:0060966)	2.53842705
96	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.51112809
97	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.50257264
98	termination of RNA polymerase III transcription (GO:0006386)	2.50257264
99	protein localization to kinetochore (GO:0034501)	2.49913322
100	synapsis (GO:0007129)	10.2584777

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.68895905
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.50645180
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.33634387
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.09332424
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.02979384
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.71235936
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.67164221
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.39533928
9	E2F7_22180533_ChIP-Seq_HELA_Human	2.29708684
10	FUS_26573619_Chip-Seq_HEK293_Human	2.27140751
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.13562419
12	EWS_26573619_Chip-Seq_HEK293_Human	2.07689894
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.07038846
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02772026
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.02440300
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.01948689
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97960760
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.97260900
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.95778532
20	VDR_22108803_ChIP-Seq_LS180_Human	1.94296743
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.90154645
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.84314223
23	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.82025202
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.74635831
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.74128313
26	P300_19829295_ChIP-Seq_ESCs_Human	1.73900086
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.72988524
28	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.70726570
29	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.67482476
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.60578217
31	VDR_23849224_ChIP-Seq_CD4+_Human	1.59400580
32	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.58069970
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.57309138
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.56178174
35	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.54788106
36	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.53306066
37	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.52351987
38	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.51450319
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.48636162
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48293872
41	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.46937848
42	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.46937848
43	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.46937848
44	TAF15_26573619_Chip-Seq_HEK293_Human	1.42138237
45	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.42010955
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40234539
47	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.39889874
48	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.37668311
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.36895514
50	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.35075475
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34845418
52	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.34365344
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33672564
54	DCP1A_22483619_ChIP-Seq_HELA_Human	1.33202080
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.32432461
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28093492
57	GABP_19822575_ChIP-Seq_HepG2_Human	1.25488494
58	AR_25329375_ChIP-Seq_VCAP_Human	1.25100535
59	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.24978379
60	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.23610569
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23545831
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.23545831
63	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.23015084
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22624391
65	EZH2_22144423_ChIP-Seq_EOC_Human	1.22182294
66	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.20856469
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18853658
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18853658
69	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.16417508
70	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.16057672
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.14718298
72	MYC_19829295_ChIP-Seq_ESCs_Human	1.14673071
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.14413223
74	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.13354934
75	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.10975843
76	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.10059671
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08123314
78	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07478062
79	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.07427417
80	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06336220
81	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.03345444
82	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.03338078
83	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02947412
84	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.02947412
85	STAT3_23295773_ChIP-Seq_U87_Human	1.00881151
86	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00609089
87	ERA_21632823_ChIP-Seq_H3396_Human	1.00534115
88	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00117934
89	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.99761065
90	TTF2_22483619_ChIP-Seq_HELA_Human	0.98170546
91	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.98026626
92	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97515762
93	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.96992886
94	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.96156489
95	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.96137250
96	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.95679580
97	TCF4_23295773_ChIP-Seq_U87_Human	0.94512157
98	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.94316782
99	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.93364433
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.92656455

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	7.61407068
2	MP0003890_abnormal_embryonic-extraembry	4.30873934
3	MP0010030_abnormal_orbit_morphology	3.65895889
4	MP0001984_abnormal_olfaction	3.28130855
5	MP0002210_abnormal_sex_determination	3.26118009
6	MP0008058_abnormal_DNA_repair	3.12507879
7	MP0001929_abnormal_gametogenesis	3.05088153
8	MP0002160_abnormal_reproductive_system	3.04941685
9	MP0005499_abnormal_olfactory_system	2.80813429
10	MP0005394_taste/olfaction_phenotype	2.80813429
11	MP0005410_abnormal_fertilization	2.75206459
12	MP0003698_abnormal_male_reproductive	2.73934143
13	MP0003718_maternal_effect	2.57902680
14	MP0001145_abnormal_male_reproductive	2.49900797
15	MP0008004_abnormal_stomach_pH	2.47645354
16	MP0000653_abnormal_sex_gland	2.35492992
17	MP0008789_abnormal_olfactory_epithelium	2.19715674
18	MP0008995_early_reproductive_senescence	2.16646486
19	MP0010094_abnormal_chromosome_stability	1.96772815
20	MP0003693_abnormal_embryo_hatching	1.95226616
21	MP0003119_abnormal_digestive_system	1.94358388
22	MP0003880_abnormal_central_pattern	1.81916635
23	MP0005389_reproductive_system_phenotype	1.78433860
24	MP0008057_abnormal_DNA_replication	1.65013127
25	MP0001986_abnormal_taste_sensitivity	1.64796419
26	MP0003646_muscle_fatigue	1.59700341
27	MP0003077_abnormal_cell_cycle	1.58799681
28	MP0003136_yellow_coat_color	1.55664274
29	MP0002233_abnormal_nose_morphology	1.53904121
30	MP0002161_abnormal_fertility/fecundity	1.53324934
31	MP0004957_abnormal_blastocyst_morpholog	1.49202599
32	MP0004133_heterotaxia	1.45182199
33	MP0002084_abnormal_developmental_patter	1.37871456
34	MP0000383_abnormal_hair_follicle	1.34285160
35	MP0003937_abnormal_limbs/digits/tail_de	1.30300058
36	MP0003315_abnormal_perineum_morphology	1.28186779
37	MP0006292_abnormal_olfactory_placode	1.27431980
38	MP0001119_abnormal_female_reproductive	1.22382639
39	MP0002282_abnormal_trachea_morphology	1.21569386
40	MP0000427_abnormal_hair_cycle	1.19986519
41	MP0008932_abnormal_embryonic_tissue	1.14844719
42	MP0005423_abnormal_somatic_nervous	1.11864240
43	MP0006072_abnormal_retinal_apoptosis	1.11687805
44	MP0006035_abnormal_mitochondrial_morpho	1.11650332
45	MP0003786_premature_aging	1.09641000
46	MP0005174_abnormal_tail_pigmentation	1.09610043
47	MP0003699_abnormal_female_reproductive	1.06250325
48	MP0003111_abnormal_nucleus_morphology	1.04736999
49	MP0008007_abnormal_cellular_replicative	1.02658713
50	MP0005380_embryogenesis_phenotype	1.01140913
51	MP0001672_abnormal_embryogenesis/_devel	1.01140913
52	MP0000049_abnormal_middle_ear	0.99040810
53	MP0001188_hyperpigmentation	0.98642202
54	MP0009379_abnormal_foot_pigmentation	0.95623271
55	MP0003936_abnormal_reproductive_system	0.95564654
56	MP0003195_calcinosis	0.95339074
57	MP0003011_delayed_dark_adaptation	0.95139582
58	MP0010678_abnormal_skin_adnexa	0.94186225
59	MP0006036_abnormal_mitochondrial_physio	0.92457020
60	MP0005647_abnormal_sex_gland	0.91460473
61	MP0002085_abnormal_embryonic_tissue	0.90928285
62	MP0004019_abnormal_vitamin_homeostasis	0.88654456
63	MP0001293_anophthalmia	0.88615713
64	MP0002249_abnormal_larynx_morphology	0.88173744
65	MP0001764_abnormal_homeostasis	0.83417167
66	MP0001286_abnormal_eye_development	0.83202787
67	MP0005248_abnormal_Harderian_gland	0.82687422
68	MP0003984_embryonic_growth_retardation	0.81802306
69	MP0005551_abnormal_eye_electrophysiolog	0.80303006
70	MP0001697_abnormal_embryo_size	0.79105759
71	MP0003186_abnormal_redox_activity	0.79070281
72	MP0005253_abnormal_eye_physiology	0.78542150
73	MP0002088_abnormal_embryonic_growth/wei	0.77619117
74	MP0005395_other_phenotype	0.77285378
75	MP0005084_abnormal_gallbladder_morpholo	0.76796961
76	MP0003938_abnormal_ear_development	0.75371378
77	MP0001730_embryonic_growth_arrest	0.74367835
78	MP0009697_abnormal_copulation	0.72793246
79	MP0000678_abnormal_parathyroid_gland	0.71066289
80	MP0001919_abnormal_reproductive_system	0.70678151
81	MP0000631_abnormal_neuroendocrine_gland	0.66108033
82	MP0010368_abnormal_lymphatic_system	0.65407277
83	MP0002184_abnormal_innervation	0.63588287
84	MP0000537_abnormal_urethra_morphology	0.63356011
85	MP0003943_abnormal_hepatobiliary_system	0.62552850
86	MP0001529_abnormal_vocalization	0.62144993
87	MP0002111_abnormal_tail_morphology	0.62126330
88	MP0003861_abnormal_nervous_system	0.61435781
89	MP0002254_reproductive_system_inflammat	0.60408349
90	MP0001485_abnormal_pinna_reflex	0.59743493
91	MP0004885_abnormal_endolymph	0.57178023
92	MP0005409_darkened_coat_color	0.57042070
93	MP0009250_abnormal_appendicular_skeleto	0.54804130
94	MP0002638_abnormal_pupillary_reflex	0.54668736
95	MP0000647_abnormal_sebaceous_gland	0.54629158
96	MP0002752_abnormal_somatic_nervous	0.54143828
97	MP0008872_abnormal_physiological_respon	0.52456391
98	MP0003935_abnormal_craniofacial_develop	0.50064744
99	MP0004215_abnormal_myocardial_fiber	0.49951202
100	MP0000566_synostosis	0.49800137

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	4.51732016
2	Absent/shortened dynein arms (HP:0200106)	4.40574106
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.40574106
4	Abnormal ciliary motility (HP:0012262)	4.37184094
5	Abnormal respiratory motile cilium morphology (HP:0005938)	4.18935303
6	Abnormal respiratory epithelium morphology (HP:0012253)	4.18935303
7	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.07684530
8	Type I transferrin isoform profile (HP:0003642)	3.89407919
9	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.67920772
10	Abnormal protein N-linked glycosylation (HP:0012347)	3.67920772
11	Abnormal protein glycosylation (HP:0012346)	3.67920772
12	Abnormal glycosylation (HP:0012345)	3.67920772
13	Rhinitis (HP:0012384)	3.47522901
14	Gonadotropin excess (HP:0000837)	3.43473299
15	Pancreatic cysts (HP:0001737)	3.35426125
16	Abnormality of midbrain morphology (HP:0002418)	3.14139963
17	Molar tooth sign on MRI (HP:0002419)	3.14139963
18	Pancreatic fibrosis (HP:0100732)	3.08327377
19	Infertility (HP:0000789)	2.98518244
20	Abnormal lung lobation (HP:0002101)	2.96950826
21	Horizontal nystagmus (HP:0000666)	2.93671618
22	Supernumerary spleens (HP:0009799)	2.93588802
23	Abnormal biliary tract physiology (HP:0012439)	2.91575294
24	Bile duct proliferation (HP:0001408)	2.91575294
25	Tubulointerstitial nephritis (HP:0001970)	2.90507036
26	Abnormality of the labia minora (HP:0012880)	2.86417989
27	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.83868416
28	Oligodactyly (hands) (HP:0001180)	2.82397680
29	True hermaphroditism (HP:0010459)	2.77211272
30	Broad distal phalanx of finger (HP:0009836)	2.74633415
31	Cystic liver disease (HP:0006706)	2.69106897
32	Abnormal pancreas size (HP:0012094)	2.64137365
33	Bronchiectasis (HP:0002110)	2.59674496
34	Medial flaring of the eyebrow (HP:0010747)	2.55430646
35	Small intestinal stenosis (HP:0012848)	2.53768558
36	Duodenal stenosis (HP:0100867)	2.53768558
37	Occipital encephalocele (HP:0002085)	2.53535604
38	Meckel diverticulum (HP:0002245)	2.50821383
39	Male pseudohermaphroditism (HP:0000037)	2.47147710
40	Abnormality of the ileum (HP:0001549)	2.43747834
41	Abnormality of chromosome stability (HP:0003220)	2.43170234
42	Preaxial hand polydactyly (HP:0001177)	2.41395728
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.41210806
44	Anophthalmia (HP:0000528)	2.37595800
45	Azoospermia (HP:0000027)	2.35531254
46	Abnormality of abdominal situs (HP:0011620)	2.35336326
47	Abdominal situs inversus (HP:0003363)	2.35336326
48	Volvulus (HP:0002580)	2.33686260
49	Chronic bronchitis (HP:0004469)	2.31822075
50	Nephronophthisis (HP:0000090)	2.31172328
51	Short tibia (HP:0005736)	2.29928216
52	Chromsome breakage (HP:0040012)	2.24783953
53	Anencephaly (HP:0002323)	2.22007181
54	Shoulder girdle muscle weakness (HP:0003547)	2.21682976
55	Abnormality of the duodenum (HP:0002246)	2.21107779
56	Abnormality of the renal medulla (HP:0100957)	2.20691012
57	Congenital primary aphakia (HP:0007707)	2.19701548
58	Genital tract atresia (HP:0001827)	2.18696079
59	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.15947445
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15159843
61	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.14001978
62	Vaginal atresia (HP:0000148)	2.12474795
63	Resting tremor (HP:0002322)	2.09050777
64	Optic nerve hypoplasia (HP:0000609)	2.09002947
65	Gait imbalance (HP:0002141)	2.08970320
66	Abnormality of the preputium (HP:0100587)	2.08917372
67	Facial hemangioma (HP:0000329)	2.06122997
68	Nephrogenic diabetes insipidus (HP:0009806)	2.01909457
69	Absent radius (HP:0003974)	2.00439549
70	Sclerocornea (HP:0000647)	1.99439800
71	Septo-optic dysplasia (HP:0100842)	1.98282631
72	Abnormality of alanine metabolism (HP:0010916)	1.95513854
73	Hyperalaninemia (HP:0003348)	1.95513854
74	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.95513854
75	Type II lissencephaly (HP:0007260)	1.91045630
76	Fused cervical vertebrae (HP:0002949)	1.89664983
77	Median cleft lip (HP:0000161)	1.88465084
78	Abnormality of the renal cortex (HP:0011035)	1.87502326
79	Absent forearm bone (HP:0003953)	1.87266141
80	Aplasia involving forearm bones (HP:0009822)	1.87266141
81	Inability to walk (HP:0002540)	1.86944050
82	Non-midline cleft lip (HP:0100335)	1.83188427
83	Hypoplasia of the pons (HP:0012110)	1.82411585
84	Progressive inability to walk (HP:0002505)	1.81496670
85	Abnormal spermatogenesis (HP:0008669)	1.81154732
86	Ectopic kidney (HP:0000086)	1.80839300
87	Horseshoe kidney (HP:0000085)	1.80477260
88	Stenosis of the external auditory canal (HP:0000402)	1.80114546
89	Increased serum pyruvate (HP:0003542)	1.80108241
90	Rimmed vacuoles (HP:0003805)	1.79499984
91	Abnormality of the septum pellucidum (HP:0007375)	1.79441658
92	Aplasia/hypoplasia of the uterus (HP:0008684)	1.78685298
93	Absent septum pellucidum (HP:0001331)	1.78422692
94	Absent speech (HP:0001344)	1.77976579
95	Hypoplasia of the uterus (HP:0000013)	1.77393134
96	Polydipsia (HP:0001959)	1.77035072
97	Abnormal drinking behavior (HP:0030082)	1.77035072
98	Tubular atrophy (HP:0000092)	1.75631545
99	Methylmalonic acidemia (HP:0002912)	1.73913093
100	Abnormality of the pons (HP:0007361)	1.72296331

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	5.99571557
2	PINK1	4.54499726
3	CDK19	3.72736345
4	MET	3.30287325
5	PLK4	3.21002215
6	ACVR1B	2.98321821
7	ZAK	2.64863605
8	BMPR1B	2.63951300
9	CDC7	2.39083912
10	CAMK1G	2.36096123
11	OXSR1	2.22567215
12	PTK2B	2.12164864
13	PLK2	2.07858267
14	SRPK1	2.02506563
15	PBK	1.87309402
16	MST4	1.79319857
17	MAP3K9	1.79265047
18	MARK3	1.75420186
19	WEE1	1.71006801
20	BMX	1.70214896
21	STK38L	1.69163771
22	TTK	1.60621366
23	TRIM28	1.58437798
24	FGR	1.57940523
25	DYRK3	1.49666555
26	TLK1	1.49174081
27	CASK	1.47895991
28	VRK1	1.41153972
29	PDK2	1.40004994
30	PLK1	1.32644153
31	NEK1	1.29593897
32	NEK2	1.27662462
33	EIF2AK3	1.21287795
34	WNK3	1.16933560
35	MST1R	1.14861630
36	PLK3	1.14042397
37	TNIK	1.12156592
38	MAP3K4	1.11974990
39	TSSK6	1.11854236
40	MAP2K7	1.05309029
41	CSF1R	1.04784032
42	TGFBR1	1.03888311
43	RPS6KA5	1.00163678
44	FRK	0.90612027
45	MAP4K2	0.89629488
46	WNK4	0.89253829
47	STK16	0.87877561
48	EPHA4	0.85138621
49	STK39	0.82669939
50	ATR	0.73752902
51	MAP3K10	0.66715532
52	NUAK1	0.66571235
53	DYRK2	0.66142135
54	ERBB4	0.65800024
55	FGFR2	0.62567258
56	MAP3K13	0.62126037
57	AURKA	0.61485320
58	CHEK2	0.60396520
59	CHEK1	0.60245207
60	CDK3	0.54693697
61	PRKCI	0.54250782
62	ATM	0.52870643
63	NEK6	0.50905910
64	ADRBK1	0.49895365
65	NME1	0.49457291
66	PASK	0.49222618
67	EGFR	0.47063318
68	CDK7	0.46298911
69	MYLK	0.45347438
70	BUB1	0.44509942
71	MELK	0.43687222
72	EIF2AK1	0.41699410
73	GRK1	0.41074171
74	AURKB	0.39166728
75	STK24	0.37951248
76	ARAF	0.37950651
77	MKNK2	0.36480674
78	MAPK15	0.35121827
79	BRSK2	0.34533232
80	RET	0.34478974
81	TAF1	0.32575968
82	CAMK1	0.31703365
83	STK3	0.30721865
84	CDK9	0.30658661
85	VRK2	0.29667593
86	CSNK2A1	0.28135908
87	NLK	0.28019255
88	FGFR1	0.26638013
89	PDGFRB	0.25072995
90	CSNK1E	0.23874611
91	CDK14	0.23071901
92	CSNK2A2	0.22869307
93	CDK11A	0.22768222
94	TIE1	0.22702875
95	MAPK13	0.21309291
96	CDK1	0.21012098
97	ADRBK2	0.20359525
98	PRKG1	0.20047644
99	PRKCQ	0.19787818
100	EIF2AK2	0.19219035

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.78608212
2	Homologous recombination_Homo sapiens_hsa03440	3.00854306
3	Mismatch repair_Homo sapiens_hsa03430	2.64393673
4	Propanoate metabolism_Homo sapiens_hsa00640	2.58108969
5	Butanoate metabolism_Homo sapiens_hsa00650	2.49610363
6	Basal transcription factors_Homo sapiens_hsa03022	2.38853652
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.37453609
8	Proteasome_Homo sapiens_hsa03050	2.33678582
9	RNA degradation_Homo sapiens_hsa03018	2.32234489
10	RNA transport_Homo sapiens_hsa03013	2.29492529
11	RNA polymerase_Homo sapiens_hsa03020	2.23031468
12	DNA replication_Homo sapiens_hsa03030	2.22591685
13	Parkinsons disease_Homo sapiens_hsa05012	2.20495731
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.19874462
15	Ribosome_Homo sapiens_hsa03010	2.08894756
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.98573653
17	Huntingtons disease_Homo sapiens_hsa05016	1.90615567
18	Protein export_Homo sapiens_hsa03060	1.90042206
19	Regulation of autophagy_Homo sapiens_hsa04140	1.82475835
20	Base excision repair_Homo sapiens_hsa03410	1.80155075
21	Cell cycle_Homo sapiens_hsa04110	1.76996156
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.76940301
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.75656104
24	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.70217200
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.53111074
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.50366298
27	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.47454886
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.45261499
29	Oocyte meiosis_Homo sapiens_hsa04114	1.45138222
30	Pyruvate metabolism_Homo sapiens_hsa00620	1.44712518
31	Caffeine metabolism_Homo sapiens_hsa00232	1.41201416
32	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.40890804
33	mRNA surveillance pathway_Homo sapiens_hsa03015	1.35822263
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.32184522
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.25631399
36	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.25469832
37	Non-homologous end-joining_Homo sapiens_hsa03450	1.19994963
38	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.18412268
39	Sulfur relay system_Homo sapiens_hsa04122	1.16243503
40	Fatty acid metabolism_Homo sapiens_hsa01212	1.13296361
41	Spliceosome_Homo sapiens_hsa03040	1.12108154
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.10655272
43	Retinol metabolism_Homo sapiens_hsa00830	1.09843668
44	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.04703432
45	Fatty acid degradation_Homo sapiens_hsa00071	1.01052669
46	Purine metabolism_Homo sapiens_hsa00230	1.00899982
47	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.00563401
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.99437484
49	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98879817
50	Alzheimers disease_Homo sapiens_hsa05010	0.96759248
51	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.95881637
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.94358362
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.94069759
54	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.92314085
55	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.91155840
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.87950145
57	Fatty acid elongation_Homo sapiens_hsa00062	0.87106222
58	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.86980646
59	Olfactory transduction_Homo sapiens_hsa04740	0.86165462
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.84477184
61	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.82942729
62	Peroxisome_Homo sapiens_hsa04146	0.79034606
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74530043
64	Metabolic pathways_Homo sapiens_hsa01100	0.74011662
65	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.72599325
66	Glutathione metabolism_Homo sapiens_hsa00480	0.71936555
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71775551
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65989202
69	Cardiac muscle contraction_Homo sapiens_hsa04260	0.64610360
70	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.63601709
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.62525366
72	Alcoholism_Homo sapiens_hsa05034	0.62273759
73	p53 signaling pathway_Homo sapiens_hsa04115	0.60988103
74	Taste transduction_Homo sapiens_hsa04742	0.60496085
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.60457057
76	Phototransduction_Homo sapiens_hsa04744	0.60185701
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58983128
78	Wnt signaling pathway_Homo sapiens_hsa04310	0.53635877
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.52952146
80	Linoleic acid metabolism_Homo sapiens_hsa00591	0.52375505
81	Gap junction_Homo sapiens_hsa04540	0.49942842
82	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.48723270
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46618254
84	Lysine degradation_Homo sapiens_hsa00310	0.46198805
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45405500
86	Carbon metabolism_Homo sapiens_hsa01200	0.42228680
87	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.41577787
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40594751
89	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.37745324
90	Basal cell carcinoma_Homo sapiens_hsa05217	0.36970194
91	Nicotine addiction_Homo sapiens_hsa05033	0.36738512
92	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.35180850
93	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.34870231
94	One carbon pool by folate_Homo sapiens_hsa00670	0.34830581
95	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.31361294
96	Folate biosynthesis_Homo sapiens_hsa00790	0.29594171
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.28562951
98	Ether lipid metabolism_Homo sapiens_hsa00565	0.25338670
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.24312553
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.23773835

SLC25A3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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