ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	5.90211317
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.15801998
3	ATP synthesis coupled proton transport (GO:0015986)	5.15801998
4	water-soluble vitamin biosynthetic process (GO:0042364)	4.99895976
5	amino acid salvage (GO:0043102)	4.95410212
6	L-methionine salvage (GO:0071267)	4.95410212
7	L-methionine biosynthetic process (GO:0071265)	4.95410212
8	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.90917775
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.77844754
10	proteasome assembly (GO:0043248)	4.65911933
11	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.42427536
12	cullin deneddylation (GO:0010388)	4.14954874
13	electron transport chain (GO:0022900)	4.06576875
14	respiratory electron transport chain (GO:0022904)	4.05638292
15	respiratory chain complex IV assembly (GO:0008535)	4.02943840
16	methionine biosynthetic process (GO:0009086)	4.02815915
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.91927220
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.91927220
19	NADH dehydrogenase complex assembly (GO:0010257)	3.91927220
20	protein complex biogenesis (GO:0070271)	3.78858760
21	peptidyl-histidine modification (GO:0018202)	3.74006215
22	termination of RNA polymerase III transcription (GO:0006386)	3.73837193
23	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.73837193
24	protein deneddylation (GO:0000338)	3.73691699
25	one-carbon compound transport (GO:0019755)	3.70040690
26	DNA synthesis involved in DNA repair (GO:0000731)	3.63103800
27	sequestering of actin monomers (GO:0042989)	3.62302363
28	iron-sulfur cluster assembly (GO:0016226)	3.62115318
29	metallo-sulfur cluster assembly (GO:0031163)	3.62115318
30	regulation of cilium movement (GO:0003352)	3.61475434
31	mitochondrial respiratory chain complex assembly (GO:0033108)	3.60385548
32	DNA deamination (GO:0045006)	3.59688301
33	ATP biosynthetic process (GO:0006754)	3.45483374
34	negative regulation of heart rate (GO:0010459)	3.44303145
35	regulation of helicase activity (GO:0051095)	3.38781643
36	piRNA metabolic process (GO:0034587)	3.37737297
37	methionine metabolic process (GO:0006555)	3.34804624
38	centriole replication (GO:0007099)	3.34318924
39	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.33149472
40	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.31797407
41	aspartate family amino acid biosynthetic process (GO:0009067)	3.28184349
42	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	3.26962181
43	positive regulation of lamellipodium assembly (GO:0010592)	3.25714263
44	S-adenosylmethionine metabolic process (GO:0046500)	3.24716472
45	protein neddylation (GO:0045116)	3.24543737
46	regulation of cellular amino acid metabolic process (GO:0006521)	3.19946726
47	protein prenylation (GO:0018342)	3.18567737
48	prenylation (GO:0097354)	3.18567737
49	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.15096294
50	hydrogen ion transmembrane transport (GO:1902600)	3.11875257
51	branched-chain amino acid catabolic process (GO:0009083)	3.10799985
52	mismatch repair (GO:0006298)	3.10770759
53	oxidative phosphorylation (GO:0006119)	3.10560541
54	rRNA modification (GO:0000154)	3.09109303
55	platelet dense granule organization (GO:0060155)	3.07008729
56	axoneme assembly (GO:0035082)	3.06843404
57	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.06825475
58	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.04497778
59	cytochrome complex assembly (GO:0017004)	3.03245552
60	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.03158945
61	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.96149121
62	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.95496926
63	proton transport (GO:0015992)	2.95026151
64	neural tube formation (GO:0001841)	2.95003082
65	sulfur amino acid biosynthetic process (GO:0000097)	2.92680173
66	transepithelial transport (GO:0070633)	2.89905971
67	hydrogen transport (GO:0006818)	2.89640958
68	regulation of regulatory T cell differentiation (GO:0045589)	2.88980322
69	mitochondrial RNA metabolic process (GO:0000959)	2.88812498
70	B cell mediated immunity (GO:0019724)	2.86903074
71	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.86152773
72	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.86152773
73	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.84554194
74	immunoglobulin mediated immune response (GO:0016064)	2.83370274
75	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.83238386
76	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.83238386
77	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.83238386
78	negative regulation of appetite (GO:0032099)	2.81252257
79	negative regulation of response to food (GO:0032096)	2.81252257
80	deoxyribose phosphate biosynthetic process (GO:0046385)	2.80411702
81	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.80411702
82	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.79754602
83	GPI anchor metabolic process (GO:0006505)	2.77562601
84	mannosylation (GO:0097502)	2.77117705
85	protein targeting to mitochondrion (GO:0006626)	2.76275075
86	GPI anchor biosynthetic process (GO:0006506)	2.75698047
87	xenobiotic catabolic process (GO:0042178)	2.73717556
88	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.72624339
89	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.72083228
90	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.72083228
91	spliceosomal snRNP assembly (GO:0000387)	2.66656627
92	autophagic vacuole fusion (GO:0000046)	2.66619235
93	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.63728487
94	establishment of protein localization to mitochondrion (GO:0072655)	2.63573403
95	cytidine metabolic process (GO:0046087)	2.62982808
96	cytidine catabolic process (GO:0006216)	2.62982808
97	cytidine deamination (GO:0009972)	2.62982808
98	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.62075941
99	aldehyde catabolic process (GO:0046185)	2.60242199
100	chaperone-mediated protein transport (GO:0072321)	2.60100425

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.40793260
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.31104859
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.22396780
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.01075625
5	VDR_22108803_ChIP-Seq_LS180_Human	3.56103532
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.00219799
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.94305824
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.91667998
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.74497571
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.66056508
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.58370368
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31442968
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.28319555
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.26573067
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.25905647
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.17684642
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94244810
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.91455447
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.90535556
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.85186493
21	HTT_18923047_ChIP-ChIP_STHdh_Human	1.78497433
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.76532905
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.70436602
24	EWS_26573619_Chip-Seq_HEK293_Human	1.68411995
25	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.68010006
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.67202294
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.66919287
28	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.65112624
29	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.63555501
30	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.59191019
31	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.59146713
32	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.57948363
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.57725792
34	CIITA_25753668_ChIP-Seq_RAJI_Human	1.55350516
35	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.53939372
36	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51886191
37	AR_20517297_ChIP-Seq_VCAP_Human	1.48342408
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.44209654
39	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.40189731
40	NCOR_22424771_ChIP-Seq_293T_Human	1.39672420
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.39531604
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.39518407
43	GABP_19822575_ChIP-Seq_HepG2_Human	1.39449322
44	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.37971613
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.37371984
46	GBX2_23144817_ChIP-Seq_PC3_Human	1.37101605
47	MYC_18940864_ChIP-ChIP_HL60_Human	1.34629059
48	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.33831739
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32686302
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.32060396
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.29459500
52	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.23534086
53	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.22960010
54	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.22172301
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21609637
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21609637
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21386166
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21386166
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21340505
60	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.20924586
61	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.20865668
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20243346
63	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.19898135
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17344845
65	P300_19829295_ChIP-Seq_ESCs_Human	1.14248541
66	DCP1A_22483619_ChIP-Seq_HELA_Human	1.13682331
67	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12490055
68	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.09315099
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08525348
70	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.07186279
71	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.06813371
72	RBPJ_21746931_ChIP-Seq_IB4_Human	1.06791443
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05541013
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05260859
75	GATA3_26560356_Chip-Seq_TH2_Human	1.05109363
76	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.03319361
77	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03167203
78	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.03028869
79	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.02137967
80	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.00696509
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.97890861
82	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97880201
83	CBP_20019798_ChIP-Seq_JUKART_Human	0.97880201
84	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97525281
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96793227
86	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96593050
87	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96365772
88	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.96250723
89	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.95332964
90	ERG_20517297_ChIP-Seq_VCAP_Human	0.95054714
91	FUS_26573619_Chip-Seq_HEK293_Human	0.95040543
92	ERA_21632823_ChIP-Seq_H3396_Human	0.94255938
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.93844409
94	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.92554414
95	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.92095587
96	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.91928810
97	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.90956915
98	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.90950379
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.90793376
100	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89976254

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	3.41334879
2	MP0002102_abnormal_ear_morphology	2.92167245
3	MP0008058_abnormal_DNA_repair	2.88313770
4	MP0005671_abnormal_response_to	2.88028931
5	MP0005360_urolithiasis	2.46642966
6	MP0009697_abnormal_copulation	2.38145905
7	MP0002837_dystrophic_cardiac_calcinosis	2.36697906
8	MP0003787_abnormal_imprinting	2.29009096
9	MP0008877_abnormal_DNA_methylation	2.25117913
10	MP0006292_abnormal_olfactory_placode	2.21366621
11	MP0000372_irregular_coat_pigmentation	2.15998971
12	MP0008995_early_reproductive_senescence	2.15628780
13	MP0008789_abnormal_olfactory_epithelium	2.08311110
14	MP0006072_abnormal_retinal_apoptosis	2.05103784
15	MP0005645_abnormal_hypothalamus_physiol	1.91689109
16	MP0008875_abnormal_xenobiotic_pharmacok	1.91534674
17	MP0003880_abnormal_central_pattern	1.86216567
18	MP0001835_abnormal_antigen_presentation	1.82499189
19	MP0003724_increased_susceptibility_to	1.81959230
20	MP0006036_abnormal_mitochondrial_physio	1.76282737
21	MP0009333_abnormal_splenocyte_physiolog	1.76012410
22	MP0005085_abnormal_gallbladder_physiolo	1.74518540
23	MP0003806_abnormal_nucleotide_metabolis	1.70121707
24	MP0003786_premature_aging	1.69979908
25	MP0006035_abnormal_mitochondrial_morpho	1.68010316
26	MP0001968_abnormal_touch/_nociception	1.64613814
27	MP0002876_abnormal_thyroid_physiology	1.60202110
28	MP0003137_abnormal_impulse_conducting	1.58390221
29	MP0005075_abnormal_melanosome_morpholog	1.58042039
30	MP0001485_abnormal_pinna_reflex	1.55971713
31	MP0004142_abnormal_muscle_tone	1.54552521
32	MP0002736_abnormal_nociception_after	1.52329841
33	MP0001873_stomach_inflammation	1.50156620
34	MP0005389_reproductive_system_phenotype	1.46752287
35	MP0005367_renal/urinary_system_phenotyp	1.45581680
36	MP0000516_abnormal_urinary_system	1.45581680
37	MP0001986_abnormal_taste_sensitivity	1.43877705
38	MP0005253_abnormal_eye_physiology	1.43861694
39	MP0005394_taste/olfaction_phenotype	1.40895634
40	MP0005499_abnormal_olfactory_system	1.40895634
41	MP0005551_abnormal_eye_electrophysiolog	1.38164772
42	MP0009764_decreased_sensitivity_to	1.37064635
43	MP0001919_abnormal_reproductive_system	1.36474807
44	MP0003646_muscle_fatigue	1.31360781
45	MP0005332_abnormal_amino_acid	1.31047225
46	MP0005646_abnormal_pituitary_gland	1.29272653
47	MP0003718_maternal_effect	1.28951556
48	MP0004145_abnormal_muscle_electrophysio	1.28122481
49	MP0009046_muscle_twitch	1.25323348
50	MP0004043_abnormal_pH_regulation	1.22119160
51	MP0001905_abnormal_dopamine_level	1.21712984
52	MP0001756_abnormal_urination	1.21210182
53	MP0003186_abnormal_redox_activity	1.20813446
54	MP0003195_calcinosis	1.20529408
55	MP0002751_abnormal_autonomic_nervous	1.19655693
56	MP0008872_abnormal_physiological_respon	1.16407598
57	MP0002166_altered_tumor_susceptibility	1.15470723
58	MP0005636_abnormal_mineral_homeostasis	1.14841855
59	MP0001119_abnormal_female_reproductive	1.11990625
60	MP0005379_endocrine/exocrine_gland_phen	1.11038464
61	MP0009785_altered_susceptibility_to	1.10691077
62	MP0002210_abnormal_sex_determination	1.09767630
63	MP0001984_abnormal_olfaction	1.09574556
64	MP0002277_abnormal_respiratory_mucosa	1.09500761
65	MP0003866_abnormal_defecation	1.05834467
66	MP0002095_abnormal_skin_pigmentation	1.04548909
67	MP0005084_abnormal_gallbladder_morpholo	1.03915901
68	MP0001764_abnormal_homeostasis	1.02216161
69	MP0001929_abnormal_gametogenesis	1.00193543
70	MP0001800_abnormal_humoral_immune	0.98179308
71	MP0001529_abnormal_vocalization	0.98087837
72	MP0002160_abnormal_reproductive_system	0.96892571
73	MP0002234_abnormal_pharynx_morphology	0.94540453
74	MP0000631_abnormal_neuroendocrine_gland	0.94081067
75	MP0009745_abnormal_behavioral_response	0.93703200
76	MP0002638_abnormal_pupillary_reflex	0.93305442
77	MP0000026_abnormal_inner_ear	0.92476169
78	MP0002693_abnormal_pancreas_physiology	0.90661121
79	MP0009643_abnormal_urine_homeostasis	0.89844041
80	MP0002148_abnormal_hypersensitivity_rea	0.88565203
81	MP0006276_abnormal_autonomic_nervous	0.88246445
82	MP0005647_abnormal_sex_gland	0.87359875
83	MP0001963_abnormal_hearing_physiology	0.85848504
84	MP0006082_CNS_inflammation	0.83804831
85	MP0000653_abnormal_sex_gland	0.83120904
86	MP0001970_abnormal_pain_threshold	0.82269662
87	MP0003121_genomic_imprinting	0.81456152
88	MP0002938_white_spotting	0.80732005
89	MP0009379_abnormal_foot_pigmentation	0.80694278
90	MP0002272_abnormal_nervous_system	0.80552898
91	MP0008775_abnormal_heart_ventricle	0.79158819
92	MP0008961_abnormal_basal_metabolism	0.77888284
93	MP0003136_yellow_coat_color	0.75924734
94	MP0005195_abnormal_posterior_eye	0.75779048
95	MP0005408_hypopigmentation	0.72350570
96	MP0003122_maternal_imprinting	0.72317636
97	MP0001765_abnormal_ion_homeostasis	0.72193742
98	MP0005377_hearing/vestibular/ear_phenot	0.71961449
99	MP0003878_abnormal_ear_physiology	0.71961449
100	MP0002733_abnormal_thermal_nociception	0.71639905

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	5.17667688
2	Acute necrotizing encephalopathy (HP:0006965)	5.15403674
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.77915108
4	Mitochondrial inheritance (HP:0001427)	4.71730853
5	Acute encephalopathy (HP:0006846)	4.62173047
6	Progressive macrocephaly (HP:0004481)	4.48423292
7	Hepatocellular necrosis (HP:0001404)	4.25272170
8	Increased CSF lactate (HP:0002490)	4.21281729
9	3-Methylglutaconic aciduria (HP:0003535)	4.08621394
10	Thyroid-stimulating hormone excess (HP:0002925)	4.07985866
11	Hepatic necrosis (HP:0002605)	3.77943111
12	Cerebral edema (HP:0002181)	3.46182329
13	Hyperglycinuria (HP:0003108)	3.28800285
14	Congenital stationary night blindness (HP:0007642)	3.15546892
15	Abnormality of serine family amino acid metabolism (HP:0010894)	3.15325523
16	Abnormality of glycine metabolism (HP:0010895)	3.15325523
17	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.13492511
18	Abnormality of alanine metabolism (HP:0010916)	3.13492511
19	Hyperalaninemia (HP:0003348)	3.13492511
20	Pancreatic cysts (HP:0001737)	3.08594142
21	Lactic acidosis (HP:0003128)	3.05888159
22	Increased hepatocellular lipid droplets (HP:0006565)	2.99074614
23	Lipid accumulation in hepatocytes (HP:0006561)	2.92058929
24	Respiratory failure (HP:0002878)	2.84867847
25	Microretrognathia (HP:0000308)	2.83963379
26	Decreased central vision (HP:0007663)	2.78101884
27	Increased serum lactate (HP:0002151)	2.76238082
28	Hypoproteinemia (HP:0003075)	2.74869910
29	Optic disc pallor (HP:0000543)	2.71328873
30	Cerebellar dysplasia (HP:0007033)	2.67400115
31	Hypoplasia of the uterus (HP:0000013)	2.66551285
32	Aplasia/hypoplasia of the uterus (HP:0008684)	2.63013839
33	Limb dystonia (HP:0002451)	2.62980674
34	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.56704422
35	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.56704422
36	Hyperglycinemia (HP:0002154)	2.54789585
37	Pancreatic fibrosis (HP:0100732)	2.53834035
38	True hermaphroditism (HP:0010459)	2.51652529
39	Increased intramyocellular lipid droplets (HP:0012240)	2.51147921
40	CNS demyelination (HP:0007305)	2.50468817
41	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.49691136
42	Short tibia (HP:0005736)	2.47143620
43	Leukodystrophy (HP:0002415)	2.41332309
44	Type II lissencephaly (HP:0007260)	2.41224164
45	Degeneration of anterior horn cells (HP:0002398)	2.41066612
46	Abnormality of the anterior horn cell (HP:0006802)	2.41066612
47	Hypothermia (HP:0002045)	2.40148800
48	Methylmalonic acidemia (HP:0002912)	2.40125364
49	Nephrogenic diabetes insipidus (HP:0009806)	2.37992332
50	Medial flaring of the eyebrow (HP:0010747)	2.35132149
51	Congenital, generalized hypertrichosis (HP:0004540)	2.29641805
52	Exercise intolerance (HP:0003546)	2.27756933
53	Lethargy (HP:0001254)	2.27181098
54	Renal Fanconi syndrome (HP:0001994)	2.22789499
55	Attenuation of retinal blood vessels (HP:0007843)	2.21902286
56	Abnormality of serum amino acid levels (HP:0003112)	2.21714158
57	Pancytopenia (HP:0001876)	2.17417147
58	Exertional dyspnea (HP:0002875)	2.17146790
59	Increased muscle lipid content (HP:0009058)	2.14714239
60	Abnormality of midbrain morphology (HP:0002418)	2.14552527
61	Molar tooth sign on MRI (HP:0002419)	2.14552527
62	Congenital primary aphakia (HP:0007707)	2.09919790
63	Glycosuria (HP:0003076)	2.05961900
64	Abnormality of urine glucose concentration (HP:0011016)	2.05961900
65	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.05027870
66	Abolished electroretinogram (ERG) (HP:0000550)	2.02870967
67	Lissencephaly (HP:0001339)	2.01254335
68	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.99844854
69	Severe combined immunodeficiency (HP:0004430)	1.98004265
70	Methylmalonic aciduria (HP:0012120)	1.97710967
71	Colon cancer (HP:0003003)	1.95225210
72	Gait imbalance (HP:0002141)	1.95020400
73	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.92156452
74	Progressive microcephaly (HP:0000253)	1.90135845
75	Cerebral hypomyelination (HP:0006808)	1.89733372
76	Posterior subcapsular cataract (HP:0007787)	1.88989853
77	Generalized aminoaciduria (HP:0002909)	1.87661641
78	Type 2 muscle fiber atrophy (HP:0003554)	1.84948746
79	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.83622850
80	X-linked dominant inheritance (HP:0001423)	1.83569275
81	Blindness (HP:0000618)	1.83373131
82	Alveolar cell carcinoma (HP:0006519)	1.82201206
83	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.79117315
84	Abnormal rod and cone electroretinograms (HP:0008323)	1.79028477
85	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.76883542
86	Ketoacidosis (HP:0001993)	1.75507574
87	Pendular nystagmus (HP:0012043)	1.73800555
88	Chronic bronchitis (HP:0004469)	1.71982640
89	Metabolic acidosis (HP:0001942)	1.70502022
90	Sclerocornea (HP:0000647)	1.70411349
91	Renal cortical cysts (HP:0000803)	1.69277366
92	Unsteady gait (HP:0002317)	1.68625442
93	Dicarboxylic aciduria (HP:0003215)	1.68051841
94	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.68051841
95	Ketosis (HP:0001946)	1.67174230
96	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.64948683
97	Anencephaly (HP:0002323)	1.64028725
98	Emotional lability (HP:0000712)	1.62917815
99	Chorioretinal atrophy (HP:0000533)	1.61743419
100	Cystic liver disease (HP:0006706)	1.60468550

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NUAK1	3.66434244
2	TXK	3.51976277
3	CDK19	3.36422459
4	KDR	3.10279987
5	TAOK3	2.89896034
6	EIF2AK3	2.82269737
7	BUB1	2.72675525
8	STK16	2.62719528
9	PLK4	2.42064456
10	OXSR1	2.20937419
11	FRK	2.16948837
12	ADRBK2	2.10352747
13	MAP4K2	2.07726979
14	MKNK2	2.03094681
15	TLK1	2.01655608
16	ERBB3	1.99956384
17	STK39	1.80348806
18	ZAK	1.79949290
19	GRK1	1.75513451
20	VRK1	1.75459765
21	BMPR2	1.66490518
22	BCR	1.59923435
23	RPS6KA5	1.44216869
24	TRIM28	1.41144759
25	MKNK1	1.38561754
26	CSNK1G3	1.36481915
27	CSNK1A1L	1.31606722
28	MST4	1.27885311
29	PINK1	1.25821567
30	WNK3	1.25686033
31	LATS1	1.17089624
32	CSNK1G1	1.13758060
33	TESK2	1.08047361
34	EIF2AK1	1.05476865
35	STK3	1.02482601
36	TYRO3	0.98194925
37	BMPR1B	0.98098798
38	MAPK13	0.98033225
39	INSRR	0.97111012
40	CSNK1G2	0.95788477
41	TNK2	0.92494105
42	PLK2	0.90267335
43	BCKDK	0.87380917
44	FES	0.87268454
45	EPHA4	0.85790214
46	LIMK1	0.84913925
47	PIM2	0.82702659
48	VRK2	0.82194653
49	SIK2	0.81877099
50	TRPM7	0.81407129
51	PASK	0.81346539
52	CSNK1A1	0.75584604
53	ITK	0.74622067
54	SRPK1	0.74351765
55	EIF2AK2	0.71166378
56	NEK1	0.67933045
57	CHUK	0.66609960
58	RPS6KA4	0.65966480
59	CSF1R	0.61897230
60	ACVR1B	0.60502382
61	MYLK	0.59950393
62	LCK	0.59605606
63	ILK	0.59299969
64	PLK3	0.58200711
65	PRKCG	0.56543557
66	TEC	0.55877912
67	WNK4	0.55532674
68	LYN	0.54429101
69	OBSCN	0.54041308
70	MAP3K12	0.51904870
71	CAMKK2	0.51535776
72	AURKB	0.51246831
73	MAP2K7	0.51119963
74	MINK1	0.50906883
75	CSNK2A1	0.50286582
76	ADRBK1	0.49522267
77	NEK2	0.48729435
78	CSK	0.48101110
79	CSNK2A2	0.47409818
80	MARK3	0.46512927
81	DYRK2	0.45092491
82	IGF1R	0.42976731
83	MAP3K6	0.42809021
84	DYRK3	0.41433718
85	BTK	0.40446705
86	RAF1	0.40139033
87	ABL1	0.39466125
88	CAMK2A	0.39239411
89	MAPKAPK3	0.38614047
90	PRKACA	0.37200911
91	PRKCA	0.36382468
92	PRKCE	0.35839380
93	CASK	0.35391895
94	FLT3	0.32274175
95	ROCK1	0.31634845
96	SIK3	0.31221083
97	BRSK1	0.30300989
98	KIT	0.29172120
99	PBK	0.28744128
100	CDC7	0.28669122

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.58550964
2	Asthma_Homo sapiens_hsa05310	3.52067738
3	Proteasome_Homo sapiens_hsa03050	3.40746292
4	Parkinsons disease_Homo sapiens_hsa05012	2.96676282
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.78002723
6	RNA polymerase_Homo sapiens_hsa03020	2.77795286
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.66063752
8	Allograft rejection_Homo sapiens_hsa05330	2.61773343
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.32806211
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.08394626
11	Propanoate metabolism_Homo sapiens_hsa00640	1.96346155
12	Sulfur metabolism_Homo sapiens_hsa00920	1.94852185
13	One carbon pool by folate_Homo sapiens_hsa00670	1.94152823
14	Huntingtons disease_Homo sapiens_hsa05016	1.92586764
15	Protein export_Homo sapiens_hsa03060	1.89956762
16	Ribosome_Homo sapiens_hsa03010	1.86147783
17	Alzheimers disease_Homo sapiens_hsa05010	1.79747367
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.75183727
19	Viral myocarditis_Homo sapiens_hsa05416	1.66177315
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64536613
21	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.62774118
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.57715894
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.57286002
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.51350221
25	Basal transcription factors_Homo sapiens_hsa03022	1.51312000
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.43719400
27	Rheumatoid arthritis_Homo sapiens_hsa05323	1.40809284
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.39008942
29	Phototransduction_Homo sapiens_hsa04744	1.37429201
30	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.33434430
31	Butanoate metabolism_Homo sapiens_hsa00650	1.30561597
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30028710
33	Fatty acid elongation_Homo sapiens_hsa00062	1.27266522
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.25380821
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.21650914
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.17974364
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.10405801
38	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.09703917
39	RNA degradation_Homo sapiens_hsa03018	1.09451985
40	Peroxisome_Homo sapiens_hsa04146	1.09211276
41	Mismatch repair_Homo sapiens_hsa03430	1.08721759
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.08097262
43	RNA transport_Homo sapiens_hsa03013	1.06257745
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.00846119
45	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00845579
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.00741544
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.96329746
48	Primary immunodeficiency_Homo sapiens_hsa05340	0.94411991
49	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.92959284
50	Spliceosome_Homo sapiens_hsa03040	0.91445963
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89073540
52	Homologous recombination_Homo sapiens_hsa03440	0.88650782
53	Purine metabolism_Homo sapiens_hsa00230	0.84776631
54	Fanconi anemia pathway_Homo sapiens_hsa03460	0.84560606
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.84005780
56	Regulation of autophagy_Homo sapiens_hsa04140	0.77903733
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.74338910
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.73526194
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69969627
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69149152
61	Fatty acid degradation_Homo sapiens_hsa00071	0.68800167
62	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.67463091
63	Metabolic pathways_Homo sapiens_hsa01100	0.66332427
64	Linoleic acid metabolism_Homo sapiens_hsa00591	0.64201619
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63880725
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.63737474
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63079277
68	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.62875371
69	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.60102288
70	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57295863
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.56336452
72	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.54469463
73	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.53708170
74	Leishmaniasis_Homo sapiens_hsa05140	0.53411705
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53269517
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52862642
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.52748011
78	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52628998
79	Tyrosine metabolism_Homo sapiens_hsa00350	0.51656585
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51462230
81	Olfactory transduction_Homo sapiens_hsa04740	0.51302184
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.47596015
83	Herpes simplex infection_Homo sapiens_hsa05168	0.46986253
84	Base excision repair_Homo sapiens_hsa03410	0.46714655
85	ABC transporters_Homo sapiens_hsa02010	0.44313357
86	Carbon metabolism_Homo sapiens_hsa01200	0.43975933
87	Sulfur relay system_Homo sapiens_hsa04122	0.43288209
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42700295
89	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.42502949
90	Phenylalanine metabolism_Homo sapiens_hsa00360	0.42223870
91	Alcoholism_Homo sapiens_hsa05034	0.41224911
92	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.40950479
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38824475
94	Retinol metabolism_Homo sapiens_hsa00830	0.38650008
95	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.37896367
96	Glutathione metabolism_Homo sapiens_hsa00480	0.37192506
97	Non-homologous end-joining_Homo sapiens_hsa03450	0.36966075
98	Selenocompound metabolism_Homo sapiens_hsa00450	0.36124945
99	DNA replication_Homo sapiens_hsa03030	0.33692374
100	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.29475483

SLC25A3P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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