SLC25A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.16416672
2ATP synthesis coupled proton transport (GO:0015986)5.90228435
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.90228435
4skeletal muscle contraction (GO:0003009)5.86638871
5cardiac myofibril assembly (GO:0055003)5.47611305
6sarcomere organization (GO:0045214)5.42417217
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.37353502
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.10489324
9creatine metabolic process (GO:0006600)5.02429303
10respiratory electron transport chain (GO:0022904)5.00018270
11regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.97466570
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.93769572
13tricarboxylic acid cycle (GO:0006099)4.92747867
14negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.88850709
15electron transport chain (GO:0022900)4.87421706
16actin-myosin filament sliding (GO:0033275)4.83525803
17muscle filament sliding (GO:0030049)4.83525803
18myofibril assembly (GO:0030239)4.80382022
19regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.71465919
20cardiac muscle contraction (GO:0060048)4.65647912
21negative regulation of potassium ion transmembrane transport (GO:1901380)4.50735726
22response to inactivity (GO:0014854)4.48482275
23regulation of cell communication by electrical coupling (GO:0010649)4.40517374
24muscle contraction (GO:0006936)4.36075001
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.31219575
26regulation of relaxation of muscle (GO:1901077)4.27141075
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.10596287
28regulation of acyl-CoA biosynthetic process (GO:0050812)4.08378087
29response to muscle activity (GO:0014850)4.07830515
30regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.02526436
31sarcoplasmic reticulum calcium ion transport (GO:0070296)4.01512495
32actin-mediated cell contraction (GO:0070252)4.01328165
33regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.97715311
34regulation of membrane repolarization (GO:0060306)3.96766930
35regulation of actin filament-based movement (GO:1903115)3.94571176
36muscle system process (GO:0003012)3.93392741
37plasma membrane repair (GO:0001778)3.92795882
38cardiac muscle hypertrophy in response to stress (GO:0014898)3.89458119
39muscle hypertrophy in response to stress (GO:0003299)3.89458119
40cardiac muscle adaptation (GO:0014887)3.89458119
41regulation of cofactor metabolic process (GO:0051193)3.88606736
42regulation of coenzyme metabolic process (GO:0051196)3.88606736
43striated muscle contraction (GO:0006941)3.78209476
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75813813
45cardiac muscle cell development (GO:0055013)3.75527101
46cell communication by electrical coupling (GO:0010644)3.72269254
47oxidative phosphorylation (GO:0006119)3.66565445
48cardiac muscle tissue morphogenesis (GO:0055008)3.65007896
49muscle fiber development (GO:0048747)3.59769689
50regulation of ATPase activity (GO:0043462)3.56693814
51regulation of ATP catabolic process (GO:1903289)3.56693814
52ATP biosynthetic process (GO:0006754)3.56561075
53ventricular cardiac muscle cell action potential (GO:0086005)3.56387279
54actomyosin structure organization (GO:0031032)3.56382307
55regulation of sarcomere organization (GO:0060297)3.55647884
56cardiac muscle hypertrophy (GO:0003300)3.53532907
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.52961578
58striated muscle adaptation (GO:0014888)3.51105043
59cell communication involved in cardiac conduction (GO:0086065)3.50525000
60regulation of striated muscle contraction (GO:0006942)3.49977662
61cardiac cell development (GO:0055006)3.46957659
62detection of calcium ion (GO:0005513)3.45171739
63ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.44624753
64adult heart development (GO:0007512)3.43557386
65NADH metabolic process (GO:0006734)3.42047867
66heart contraction (GO:0060047)3.41930941
67heart process (GO:0003015)3.41930941
68regulation of skeletal muscle contraction (GO:0014819)3.41432039
69regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.41229703
70striated muscle hypertrophy (GO:0014897)3.37852511
71regulation of the force of heart contraction (GO:0002026)3.37719307
72skeletal muscle fiber development (GO:0048741)3.37351222
73positive regulation of potassium ion transmembrane transport (GO:1901381)3.34910035
74striated muscle cell development (GO:0055002)3.33923000
75muscle tissue morphogenesis (GO:0060415)3.30565357
76relaxation of cardiac muscle (GO:0055119)3.30447622
77carnitine shuttle (GO:0006853)3.29370887
78synaptic vesicle exocytosis (GO:0016079)3.22902873
79regulation of calcium ion transmembrane transporter activity (GO:1901019)3.22570099
80regulation of calcium ion transmembrane transport (GO:1903169)3.22570099
81myotube cell development (GO:0014904)3.21195809
82negative regulation of protein localization to cell surface (GO:2000009)3.19602925
83muscle cell cellular homeostasis (GO:0046716)3.18574043
84regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.17723496
85positive regulation of cation channel activity (GO:2001259)3.17324874
862-oxoglutarate metabolic process (GO:0006103)3.17262676
87positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.14153112
88heart trabecula formation (GO:0060347)3.12093120
89relaxation of muscle (GO:0090075)3.10486575
90cardiac muscle cell action potential involved in contraction (GO:0086002)3.09062007
91regulation of cardiac muscle contraction (GO:0055117)3.08939339
92glycogen catabolic process (GO:0005980)3.08623428
93positive regulation of sodium ion transport (GO:0010765)3.08581104
94regulation of potassium ion transmembrane transporter activity (GO:1901016)3.08006250
95cardiac muscle cell action potential (GO:0086001)3.07899971
96negative regulation of calcium ion transmembrane transport (GO:1903170)3.07812883
97negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.07812883
98vocalization behavior (GO:0071625)3.07163090
99gluconeogenesis (GO:0006094)3.06822671
100negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.06485383
101regulation of heart rate (GO:0002027)3.06389515
102glucan biosynthetic process (GO:0009250)3.05566523
103glycogen biosynthetic process (GO:0005978)3.05566523
104negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.05236258
105regulation of heart rate by cardiac conduction (GO:0086091)3.04774443
106skeletal muscle adaptation (GO:0043501)3.04362519
107cardiac conduction (GO:0061337)3.03939397
108ATP hydrolysis coupled proton transport (GO:0015991)3.02546111
109energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.02546111
110regulation of cation channel activity (GO:2001257)3.02229360
111regulation of potassium ion transmembrane transport (GO:1901379)3.02022845
112cardiac chamber formation (GO:0003207)3.01043258
113hydrogen ion transmembrane transport (GO:1902600)2.99819950
114cardiac ventricle formation (GO:0003211)2.98667444
115purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.96614953
116negative regulation of potassium ion transport (GO:0043267)2.94758203
117regulation of muscle contraction (GO:0006937)2.93305002
118succinate metabolic process (GO:0006105)2.92568275
119membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.92442096
120negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90997607
121regulation of muscle system process (GO:0090257)2.90507934
122muscle hypertrophy (GO:0014896)2.90131621
123aspartate family amino acid catabolic process (GO:0009068)2.89888508
124neuron cell-cell adhesion (GO:0007158)2.89632526
125purine nucleoside triphosphate biosynthetic process (GO:0009145)2.89397856
126regulation of cardiac muscle cell contraction (GO:0086004)2.89082994
127regulation of sulfur metabolic process (GO:0042762)2.86577108
128actin filament-based movement (GO:0030048)2.84577737
129calcium-mediated signaling using intracellular calcium source (GO:0035584)2.82053124
130regulation of short-term neuronal synaptic plasticity (GO:0048172)2.82014150
131response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.81684913
132neuronal action potential propagation (GO:0019227)2.81299443
133regulation of heart contraction (GO:0008016)2.78139304
134neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.77779361
135positive regulation of potassium ion transport (GO:0043268)2.77510290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.44727672
2GBX2_23144817_ChIP-Seq_PC3_Human3.32647270
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.27493227
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99696014
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95823278
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76152885
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.62043810
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.60326066
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53549760
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52068945
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52068945
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37787537
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34878986
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27787683
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24357075
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.22539087
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21856715
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06050024
19TAF15_26573619_Chip-Seq_HEK293_Human2.03079971
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.00661322
21REST_21632747_ChIP-Seq_MESCs_Mouse1.95514083
22ZNF274_21170338_ChIP-Seq_K562_Hela1.95201542
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85224506
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.83366365
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.81316671
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79883262
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.78370764
28VDR_22108803_ChIP-Seq_LS180_Human1.77167921
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73985118
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66829614
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64617362
32NR3C1_23031785_ChIP-Seq_PC12_Mouse1.63696043
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63212374
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.60210931
35DROSHA_22980978_ChIP-Seq_HELA_Human1.59568608
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59518337
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50335414
38AR_21572438_ChIP-Seq_LNCaP_Human1.48051621
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47853508
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47707033
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47299717
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45155881
43* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43807217
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42008995
45* CBX2_27304074_Chip-Seq_ESCs_Mouse1.41679079
46* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.40650196
47P300_19829295_ChIP-Seq_ESCs_Human1.39299489
48PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37374127
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35496375
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35170439
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33893114
52FUS_26573619_Chip-Seq_HEK293_Human1.33355037
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.32795816
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32119165
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31815159
56MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.31696679
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28986934
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.28470499
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28222003
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.27927331
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21244492
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.19907343
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16912901
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15209428
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14225115
66CTCF_27219007_Chip-Seq_Bcells_Human1.14110232
67ER_23166858_ChIP-Seq_MCF-7_Human1.12120310
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11591615
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10403539
70AR_25329375_ChIP-Seq_VCAP_Human1.09081622
71* RING1B_27294783_Chip-Seq_ESCs_Mouse1.09064211
72BCAT_22108803_ChIP-Seq_LS180_Human1.07493476
73TBX20_22328084_ChIP-Seq_HEART_Mouse1.04343396
74TBX20_22080862_ChIP-Seq_HEART_Mouse1.04343396
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01919094
76NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01695817
77HTT_18923047_ChIP-ChIP_STHdh_Human1.01039098
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00259876
79CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99753141
80WT1_19549856_ChIP-ChIP_CCG9911_Human0.98396249
81ERG_21242973_ChIP-ChIP_JURKAT_Human0.96675147
82AR_19668381_ChIP-Seq_PC3_Human0.95905572
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95185819
84SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94748494
85BP1_19119308_ChIP-ChIP_Hs578T_Human0.94400323
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94185643
87JUN_21703547_ChIP-Seq_K562_Human0.94165377
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93041537
89ZNF263_19887448_ChIP-Seq_K562_Human0.92628357
90IGF1R_20145208_ChIP-Seq_DFB_Human0.92621861
91* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92462614
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92297667
93* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91285893
94STAT3_23295773_ChIP-Seq_U87_Human0.90662849
95TCF4_23295773_ChIP-Seq_U87_Human0.90518969
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90447314
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90270938
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89909918
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.89705849
100SOX9_26525672_Chip-Seq_HEART_Mouse0.88228694
101RNF2_27304074_Chip-Seq_NSC_Mouse0.87530969
102YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87247894
103IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85998156
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85963612
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85807818
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85591946
107TRIM28_21343339_ChIP-Seq_HEK293_Human0.85467248
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.85074134
109TP53_20018659_ChIP-ChIP_R1E_Mouse0.84414927
110* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84347984
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84007914
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83483114
113WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83409937
114* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83346989
115RUNX2_22187159_ChIP-Seq_PCA_Human0.83167603
116* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82959079
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.82914830
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82913209
119AHR_22903824_ChIP-Seq_MCF-7_Human0.82867102
120LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82262812
121ISL1_27105846_Chip-Seq_CPCs_Mouse0.81020338
122KLF5_20875108_ChIP-Seq_MESCs_Mouse0.79981909
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.79924663
124TET1_21490601_ChIP-Seq_MESCs_Mouse0.79220702
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78990220
126DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78588735
127PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78421611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.10874208
2MP0004084_abnormal_cardiac_muscle4.11027131
3MP0003646_muscle_fatigue3.93219623
4MP0004215_abnormal_myocardial_fiber3.57560784
5* MP0000751_myopathy3.56391656
6MP0004036_abnormal_muscle_relaxation3.37779987
7MP0000749_muscle_degeneration3.22350231
8MP0003880_abnormal_central_pattern2.99102644
9MP0004859_abnormal_synaptic_plasticity2.66833574
10MP0005330_cardiomyopathy2.63299601
11MP0004145_abnormal_muscle_electrophysio2.59269994
12MP0002972_abnormal_cardiac_muscle2.44562378
13MP0003137_abnormal_impulse_conducting2.35286647
14MP0005620_abnormal_muscle_contractility2.24827794
15MP0004484_altered_response_of2.18646087
16MP0003635_abnormal_synaptic_transmissio2.11281572
17MP0004087_abnormal_muscle_fiber2.10288237
18MP0004270_analgesia1.97313719
19MP0008775_abnormal_heart_ventricle1.95483370
20MP0004085_abnormal_heartbeat1.95121942
21MP0004233_abnormal_muscle_weight1.90397991
22MP0003122_maternal_imprinting1.86267794
23MP0009046_muscle_twitch1.84062192
24* MP0002106_abnormal_muscle_physiology1.82907058
25MP0009745_abnormal_behavioral_response1.82840862
26MP0006138_congestive_heart_failure1.79293719
27MP0001968_abnormal_touch/_nociception1.75334006
28MP0002064_seizures1.74147325
29MP0001544_abnormal_cardiovascular_syste1.72866030
30MP0005385_cardiovascular_system_phenoty1.72866030
31MP0000747_muscle_weakness1.70581121
32MP0000750_abnormal_muscle_regeneration1.68736731
33MP0002063_abnormal_learning/memory/cond1.66362265
34MP0002269_muscular_atrophy1.65578432
35MP0006276_abnormal_autonomic_nervous1.64859461
36MP0001529_abnormal_vocalization1.64387300
37MP0002736_abnormal_nociception_after1.59176613
38MP0002272_abnormal_nervous_system1.59150893
39MP0000759_abnormal_skeletal_muscle1.59093270
40MP0002735_abnormal_chemical_nociception1.58988952
41* MP0005369_muscle_phenotype1.56697461
42MP0002734_abnormal_mechanical_nocicepti1.53554990
43MP0005670_abnormal_white_adipose1.50311036
44MP0004130_abnormal_muscle_cell1.48431921
45MP0005451_abnormal_body_composition1.47823321
46MP0001440_abnormal_grooming_behavior1.46602434
47MP0002572_abnormal_emotion/affect_behav1.46498906
48MP0003221_abnormal_cardiomyocyte_apopto1.42488567
49MP0010630_abnormal_cardiac_muscle1.41753889
50MP0004924_abnormal_behavior1.35088338
51MP0005386_behavior/neurological_phenoty1.35088338
52MP0002822_catalepsy1.31245168
53MP0002067_abnormal_sensory_capabilities1.29352017
54MP0002127_abnormal_cardiovascular_syste1.29181237
55MP0001486_abnormal_startle_reflex1.27390315
56* MP0006036_abnormal_mitochondrial_physio1.22856081
57MP0000013_abnormal_adipose_tissue1.21479728
58MP0006035_abnormal_mitochondrial_morpho1.19932913
59MP0001970_abnormal_pain_threshold1.16999669
60MP0002184_abnormal_innervation1.14631572
61MP0002733_abnormal_thermal_nociception1.12505168
62MP0002909_abnormal_adrenal_gland1.11742973
63MP0003950_abnormal_plasma_membrane1.11052247
64MP0004510_myositis1.10896011
65MP0005623_abnormal_meninges_morphology1.09094390
66MP0005423_abnormal_somatic_nervous1.07428497
67MP0001905_abnormal_dopamine_level1.06867921
68MP0000778_abnormal_nervous_system1.05583304
69MP0000733_abnormal_muscle_development1.05168967
70MP0004142_abnormal_muscle_tone1.03195943
71MP0008569_lethality_at_weaning0.99966528
72MP0003828_pulmonary_edema0.99225840
73MP0001501_abnormal_sleep_pattern0.94771142
74MP0003329_amyloid_beta_deposits0.94081350
75MP0004858_abnormal_nervous_system0.90750362
76MP0002234_abnormal_pharynx_morphology0.88703665
77MP0009780_abnormal_chondrocyte_physiolo0.87455298
78* MP0005266_abnormal_metabolism0.87262084
79MP0002066_abnormal_motor_capabilities/c0.87252957
80MP0001984_abnormal_olfaction0.85199584
81MP0002557_abnormal_social/conspecific_i0.83414575
82MP0002882_abnormal_neuron_morphology0.81910568
83* MP0002332_abnormal_exercise_endurance0.81843567
84MP0002108_abnormal_muscle_morphology0.81239149
85MP0004811_abnormal_neuron_physiology0.79582518
86MP0000955_abnormal_spinal_cord0.77638614
87MP0004043_abnormal_pH_regulation0.74856066
88MP0005187_abnormal_penis_morphology0.74423790
89MP0001661_extended_life_span0.74169398
90MP0000230_abnormal_systemic_arterial0.73480605
91MP0002638_abnormal_pupillary_reflex0.72416937
92MP0000003_abnormal_adipose_tissue0.72227151
93MP0006072_abnormal_retinal_apoptosis0.71416719
94MP0005551_abnormal_eye_electrophysiolog0.67134149
95MP0002971_abnormal_brown_adipose0.66199681
96MP0005646_abnormal_pituitary_gland0.66166935
97MP0003123_paternal_imprinting0.64497618
98MP0001502_abnormal_circadian_rhythm0.62183188
99MP0003121_genomic_imprinting0.61836362
100MP0001299_abnormal_eye_distance/0.61759658
101MP0005375_adipose_tissue_phenotype0.60499611
102MP0003879_abnormal_hair_cell0.60390864
103MP0004147_increased_porphyrin_level0.59711179
104* MP0000266_abnormal_heart_morphology0.58349539
105MP0003567_abnormal_fetal_cardiomyocyte0.58158686
106MP0001485_abnormal_pinna_reflex0.58122381
107MP0005666_abnormal_adipose_tissue0.57551956
108MP0002229_neurodegeneration0.56577706
109MP0002152_abnormal_brain_morphology0.56272921
110MP0002752_abnormal_somatic_nervous0.56038550
111MP0005165_increased_susceptibility_to0.54842753
112MP0002078_abnormal_glucose_homeostasis0.48826706
113MP0005535_abnormal_body_temperature0.45668816
114MP0000372_irregular_coat_pigmentation0.40604407

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.86199862
2Calf muscle hypertrophy (HP:0008981)5.15387881
3Acute necrotizing encephalopathy (HP:0006965)5.01744847
4Muscle hypertrophy of the lower extremities (HP:0008968)4.97515315
5Exercise-induced myalgia (HP:0003738)4.95495474
6Abnormal mitochondria in muscle tissue (HP:0008316)4.80081696
7Exercise-induced muscle cramps (HP:0003710)4.78644571
8Abnormality of the calf musculature (HP:0001430)4.40885932
9Atrial fibrillation (HP:0005110)4.39865710
10Progressive macrocephaly (HP:0004481)4.31146500
11Primary atrial arrhythmia (HP:0001692)4.20030212
12Ventricular tachycardia (HP:0004756)4.11897450
13Supraventricular tachycardia (HP:0004755)4.06404940
14Myopathic facies (HP:0002058)4.02793969
15Distal arthrogryposis (HP:0005684)3.98327745
16Supraventricular arrhythmia (HP:0005115)3.97566073
17Mitochondrial inheritance (HP:0001427)3.96999929
18Pheochromocytoma (HP:0002666)3.96074352
19Acute encephalopathy (HP:0006846)3.92907879
20Centrally nucleated skeletal muscle fibers (HP:0003687)3.92172436
21Distal lower limb muscle weakness (HP:0009053)3.84667309
22Muscle fiber splitting (HP:0003555)3.67296639
23Neuroendocrine neoplasm (HP:0100634)3.63402217
24Syncope (HP:0001279)3.61940598
25Prolonged QT interval (HP:0001657)3.59607442
26Increased CSF lactate (HP:0002490)3.55536038
27EMG: neuropathic changes (HP:0003445)3.49110496
28Focal motor seizures (HP:0011153)3.48049846
29Hepatocellular necrosis (HP:0001404)3.47289420
30Lipoatrophy (HP:0100578)3.47046903
31Palpitations (HP:0001962)3.43527898
32Myoglobinuria (HP:0002913)3.33779383
33Myotonia (HP:0002486)3.31195752
34Hyporeflexia of lower limbs (HP:0002600)3.28657845
35Abnormality of the left ventricular outflow tract (HP:0011103)3.24968681
36Subaortic stenosis (HP:0001682)3.24968681
37Round ear (HP:0100830)3.24965453
38Hepatic necrosis (HP:0002605)3.16599723
39Areflexia of lower limbs (HP:0002522)3.14006546
40Abnormality of glycolysis (HP:0004366)3.11864766
41Increased serum pyruvate (HP:0003542)3.11864766
42Bundle branch block (HP:0011710)3.04249822
43Frequent falls (HP:0002359)3.00377244
44Ventricular fibrillation (HP:0001663)2.95085819
45Ventricular arrhythmia (HP:0004308)2.93598546
46* EMG: myopathic abnormalities (HP:0003458)2.91881032
47Left ventricular hypertrophy (HP:0001712)2.87355718
48Myokymia (HP:0002411)2.83462501
49Dilated cardiomyopathy (HP:0001644)2.77086995
50Abnormal EKG (HP:0003115)2.76114075
51Ulnar deviation of the wrist (HP:0003049)2.71673023
52* Exercise intolerance (HP:0003546)2.69967459
53Cerebral edema (HP:0002181)2.68658654
54Distal lower limb amyotrophy (HP:0008944)2.68065490
55Calcaneovalgus deformity (HP:0001848)2.67507850
56Atonic seizures (HP:0010819)2.67302940
57Respiratory failure (HP:0002878)2.66653885
58Mildly elevated creatine phosphokinase (HP:0008180)2.59550767
59Optic disc pallor (HP:0000543)2.56251445
60Right ventricular cardiomyopathy (HP:0011663)2.53805366
61Asymmetric septal hypertrophy (HP:0001670)2.49634666
62Conjunctival hamartoma (HP:0100780)2.45079106
63Deformed tarsal bones (HP:0008119)2.44760490
64Absent phalangeal crease (HP:0006109)2.43906940
65Limb-girdle muscle atrophy (HP:0003797)2.41281148
66* Lactic acidosis (HP:0003128)2.40963881
67Rhabdomyolysis (HP:0003201)2.38325900
68Visual hallucinations (HP:0002367)2.36596146
69Lower limb amyotrophy (HP:0007210)2.34984989
70Focal seizures (HP:0007359)2.34309223
71Muscle stiffness (HP:0003552)2.33685573
72Neoplasm of the peripheral nervous system (HP:0100007)2.30313582
73Rimmed vacuoles (HP:0003805)2.30264090
74Epileptic encephalopathy (HP:0200134)2.28490469
75Difficulty running (HP:0009046)2.27414519
76Muscle fiber inclusion bodies (HP:0100299)2.27075648
77Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.26684505
78Scapular winging (HP:0003691)2.26375958
79Heart block (HP:0012722)2.26242794
80Leukodystrophy (HP:0002415)2.25579156
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22927604
82Abnormality of alanine metabolism (HP:0010916)2.22927604
83Hyperalaninemia (HP:0003348)2.22927604
84Type 1 muscle fiber predominance (HP:0003803)2.19632395
85Increased intramyocellular lipid droplets (HP:0012240)2.18749447
86Fetal akinesia sequence (HP:0001989)2.17808728
87Increased variability in muscle fiber diameter (HP:0003557)2.15087520
88Increased connective tissue (HP:0009025)2.14861820
89Progressive muscle weakness (HP:0003323)2.13598437
90* Generalized muscle weakness (HP:0003324)2.12721910
91Abnormal atrioventricular conduction (HP:0005150)2.12479765
92Proximal amyotrophy (HP:0007126)2.11149076
93Increased hepatocellular lipid droplets (HP:0006565)2.11137014
94Absence seizures (HP:0002121)2.09822022
95Neoplasm of the adrenal gland (HP:0100631)2.09503118
96Gowers sign (HP:0003391)2.07694903
97Neck muscle weakness (HP:0000467)2.06713080
98Bulbar palsy (HP:0001283)2.03170658
99Increased muscle lipid content (HP:0009058)2.02900583
100Febrile seizures (HP:0002373)2.02331190
101Abnormality of the foot musculature (HP:0001436)2.01657262
102Lipid accumulation in hepatocytes (HP:0006561)2.01405206
103Abnormal finger flexion creases (HP:0006143)2.01286338
104Athetosis (HP:0002305)2.00298607
105Abnormality of the shoulder girdle musculature (HP:0001435)1.99065657
106Double outlet right ventricle (HP:0001719)1.98591130
107Congenital malformation of the right heart (HP:0011723)1.98591130
108X-linked dominant inheritance (HP:0001423)1.98046246
109Difficulty climbing stairs (HP:0003551)1.96603337
110Hypoplastic left heart (HP:0004383)1.96312873
111Muscular dystrophy (HP:0003560)1.95629428
112Foot dorsiflexor weakness (HP:0009027)1.95358043
113Nemaline bodies (HP:0003798)1.94670081
114Anxiety (HP:0000739)1.92437591
115Abnormality of the vocal cords (HP:0008777)1.92380198
116Central scotoma (HP:0000603)1.91427041
117Increased serum lactate (HP:0002151)1.89299286
118Progressive inability to walk (HP:0002505)1.89291720
119Abnormality of skeletal muscle fiber size (HP:0012084)1.88669751
120Generalized tonic-clonic seizures (HP:0002069)1.88382199
121Malignant hyperthermia (HP:0002047)1.87785829
122Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86991723
123Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86991723
124Dialeptic seizures (HP:0011146)1.86853494
125Respiratory insufficiency due to muscle weakness (HP:0002747)1.86812328
126Weak cry (HP:0001612)1.86715380
127Hamartoma of the eye (HP:0010568)1.86423433
128Atrioventricular block (HP:0001678)1.85399396
129Hyperventilation (HP:0002883)1.84963815
130Steppage gait (HP:0003376)1.81461213
131Waddling gait (HP:0002515)1.76847769
132Abnormality of the hip-girdle musculature (HP:0001445)1.67664624
133Abnormality of the musculature of the pelvis (HP:0001469)1.67664624
134Hyperkalemia (HP:0002153)1.65073923
135Limb-girdle muscle weakness (HP:0003325)1.64374788
136Hip contracture (HP:0003273)1.64265057
137Shoulder girdle muscle weakness (HP:0003547)1.62564033
138Oligomenorrhea (HP:0000876)1.56757478
139Fatigable weakness (HP:0003473)1.53974187
140Abnormality of the neuromuscular junction (HP:0003398)1.53974187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN3.74294467
2MYLK3.29751798
3PHKG23.22149228
4PHKG13.22149228
5TTN2.98029753
6PDK32.58336601
7PDK42.58336601
8LMTK22.36985025
9NTRK32.34251586
10MAP3K42.33791862
11CASK2.29860575
12MAP3K122.07976732
13NME11.92675209
14MARK11.92347431
15MAP2K71.91775982
16MINK11.89854744
17EPHA41.86998310
18NEK11.84702291
19MUSK1.80603903
20MAP3K91.78193532
21PLK21.72453799
22PIK3CA1.65530737
23LIMK11.57158370
24ARAF1.56346110
25STK241.55605261
26PAK31.54807660
27DMPK1.49276295
28MAP2K41.48637314
29PINK11.45944044
30PDK21.44404665
31GRK71.40442001
32PIK3CG1.38930690
33CAMK2D1.38213541
34WNK41.33794516
35PNCK1.32509571
36GRK51.29858923
37CAMK2A1.26889507
38PAK61.17575542
39PTK2B1.13617072
40STK391.10478585
41KSR21.06708389
42LATS21.04471747
43MAP3K71.04011117
44MAPK131.03394213
45DAPK31.01431034
46PRPF4B0.99410304
47KSR10.98549712
48MAPKAPK30.95933293
49UHMK10.95540275
50ROCK20.95236061
51ILK0.93838048
52CDC42BPA0.92877423
53PRKAA10.91683723
54NTRK10.91060041
55ROCK10.90214243
56ERBB30.86570212
57PRKCE0.85955963
58CAMK2B0.82998869
59NTRK20.80566051
60MAPK120.80247925
61CDK50.80144138
62STK38L0.77098840
63PRKCG0.76387733
64PKN20.75481676
65CAMK2G0.75109991
66WNK10.74215213
67BCR0.73684342
68DAPK20.72505234
69AKT20.72484653
70CDK140.67836545
71FER0.67537025
72PKN10.66819056
73PRKAA20.66062955
74CAMK10.65252149
75CDK190.64967425
76TRPM70.64911011
77PRKD30.64610019
78ADRBK10.62850490
79OXSR10.61634889
80CDK180.59073308
81STK380.57707195
82SGK2230.56573382
83SGK4940.56573382
84DYRK1B0.56227045
85PRKD10.56052276
86PRKACA0.55519345
87DAPK10.55050488
88CDK150.54653695
89CAMKK20.53121229
90MAPK40.48485223
91MAP3K50.48443359
92PRKACB0.48005301
93TESK10.47850701
94BRAF0.46402337
95EPHA30.46329764
96MAP2K60.46045484
97RPS6KA30.45315913
98MAP3K60.44833416
99TIE10.44799047
100CDK11A0.44094422
101MAP2K10.43171088
102CAMK40.42749148
103STK160.41387527
104TNIK0.40088471
105BCKDK0.38413668
106RET0.38258530
107AKT30.38000743
108SGK30.37501693
109RAF10.37303372
110NEK90.37088947
111SGK10.37088042
112MAPK100.35866050
113PRKACG0.35611764
114CCNB10.35316667
115TSSK60.35314191
116MAP2K30.35035992
117CSNK1G20.34863151
118WNK30.34841204
119RIPK10.33952030
120SGK20.33431128
121PRKG10.32344515
122CAMKK10.32079814
123MAPK70.31979023
124DYRK1A0.31712384
125ZAK0.30995345
126MOS0.29624396
127STK110.28548069
128MAP4K20.24348397
129CSNK1G30.22937478
130STK40.22385085
131DYRK20.22106232
132CSNK1G10.21142659

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.49399255
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.21371506
3Cardiac muscle contraction_Homo sapiens_hsa042604.04982314
4Parkinsons disease_Homo sapiens_hsa050124.04611279
5Alzheimers disease_Homo sapiens_hsa050103.23484036
6Huntingtons disease_Homo sapiens_hsa050162.71414360
7Dilated cardiomyopathy_Homo sapiens_hsa054142.52885763
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.35090550
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.25830898
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.24253561
11Nicotine addiction_Homo sapiens_hsa050332.23915847
12Synaptic vesicle cycle_Homo sapiens_hsa047212.09395125
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.93667748
14Collecting duct acid secretion_Homo sapiens_hsa049661.73705553
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.73339407
16Circadian entrainment_Homo sapiens_hsa047131.67839360
17Arginine and proline metabolism_Homo sapiens_hsa003301.67494917
18GABAergic synapse_Homo sapiens_hsa047271.62831061
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61189036
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59716389
21Arginine biosynthesis_Homo sapiens_hsa002201.50698091
22Long-term potentiation_Homo sapiens_hsa047201.50006647
23Morphine addiction_Homo sapiens_hsa050321.45180393
24Olfactory transduction_Homo sapiens_hsa047401.44827218
25Amphetamine addiction_Homo sapiens_hsa050311.36600865
26Dopaminergic synapse_Homo sapiens_hsa047281.35436746
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32968962
28Propanoate metabolism_Homo sapiens_hsa006401.31584798
29Oxytocin signaling pathway_Homo sapiens_hsa049211.30495753
30Glutamatergic synapse_Homo sapiens_hsa047241.29524391
31Carbon metabolism_Homo sapiens_hsa012001.27916047
32* Calcium signaling pathway_Homo sapiens_hsa040201.26538107
33Taste transduction_Homo sapiens_hsa047421.26492306
34Pyruvate metabolism_Homo sapiens_hsa006201.25629181
35Phenylalanine metabolism_Homo sapiens_hsa003601.24841232
36Insulin secretion_Homo sapiens_hsa049111.24821065
37Renin secretion_Homo sapiens_hsa049241.23799139
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22024633
39Vibrio cholerae infection_Homo sapiens_hsa051101.18748305
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18434930
41Serotonergic synapse_Homo sapiens_hsa047261.15635260
42Gastric acid secretion_Homo sapiens_hsa049711.15264207
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15086979
44Salivary secretion_Homo sapiens_hsa049701.13047220
45Cholinergic synapse_Homo sapiens_hsa047251.12030949
46* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04652598
47Long-term depression_Homo sapiens_hsa047300.98932772
48Gap junction_Homo sapiens_hsa045400.95116400
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.89669325
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88408297
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85550244
52Glucagon signaling pathway_Homo sapiens_hsa049220.83848555
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82585204
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81926183
55Pentose phosphate pathway_Homo sapiens_hsa000300.79286234
56GnRH signaling pathway_Homo sapiens_hsa049120.78890512
57Cocaine addiction_Homo sapiens_hsa050300.78662152
58cAMP signaling pathway_Homo sapiens_hsa040240.77556180
59beta-Alanine metabolism_Homo sapiens_hsa004100.74174177
60Butanoate metabolism_Homo sapiens_hsa006500.65965583
61Axon guidance_Homo sapiens_hsa043600.64707057
62Fatty acid elongation_Homo sapiens_hsa000620.64017536
63Insulin resistance_Homo sapiens_hsa049310.63736305
64Melanogenesis_Homo sapiens_hsa049160.63411204
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63063244
66PPAR signaling pathway_Homo sapiens_hsa033200.61931711
67Insulin signaling pathway_Homo sapiens_hsa049100.58613273
68Phototransduction_Homo sapiens_hsa047440.58465139
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57056778
70Oocyte meiosis_Homo sapiens_hsa041140.55640050
71Proteasome_Homo sapiens_hsa030500.54943690
72Viral myocarditis_Homo sapiens_hsa054160.53939446
73Sulfur relay system_Homo sapiens_hsa041220.53233717
74Tight junction_Homo sapiens_hsa045300.53202323
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52425613
76Type II diabetes mellitus_Homo sapiens_hsa049300.52342691
77Tryptophan metabolism_Homo sapiens_hsa003800.51841314
78Estrogen signaling pathway_Homo sapiens_hsa049150.51740010
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51619621
80Regulation of autophagy_Homo sapiens_hsa041400.48976356
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48909084
82Fatty acid metabolism_Homo sapiens_hsa012120.47968861
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.45456702
84HIF-1 signaling pathway_Homo sapiens_hsa040660.43935144
85Starch and sucrose metabolism_Homo sapiens_hsa005000.43723545
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42944943
87Tyrosine metabolism_Homo sapiens_hsa003500.42630245
88Bile secretion_Homo sapiens_hsa049760.41009720
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40852500
90Peroxisome_Homo sapiens_hsa041460.40301774
91Biosynthesis of amino acids_Homo sapiens_hsa012300.40007171
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39922099
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.39666627
94Nitrogen metabolism_Homo sapiens_hsa009100.37920860
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.37221492
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36647711
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35778211
98Pancreatic secretion_Homo sapiens_hsa049720.35636674
99Glioma_Homo sapiens_hsa052140.34621291
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34309864
101Fatty acid degradation_Homo sapiens_hsa000710.34236036
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33680358
103Renal cell carcinoma_Homo sapiens_hsa052110.32940595
104Circadian rhythm_Homo sapiens_hsa047100.32844485
105Focal adhesion_Homo sapiens_hsa045100.32771962
106Ovarian steroidogenesis_Homo sapiens_hsa049130.32184172
107ErbB signaling pathway_Homo sapiens_hsa040120.31899884
108MAPK signaling pathway_Homo sapiens_hsa040100.31374681
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30953557
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29187739
111Galactose metabolism_Homo sapiens_hsa000520.29066149
112Folate biosynthesis_Homo sapiens_hsa007900.28027179
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26787314
114Fructose and mannose metabolism_Homo sapiens_hsa000510.26780787
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26112486
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25541810
117Ras signaling pathway_Homo sapiens_hsa040140.24362201
118Thyroid hormone synthesis_Homo sapiens_hsa049180.23834671
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23764230
120Rheumatoid arthritis_Homo sapiens_hsa053230.22519165
121AMPK signaling pathway_Homo sapiens_hsa041520.21977212
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.21568600
123Melanoma_Homo sapiens_hsa052180.21299941
124Phagosome_Homo sapiens_hsa041450.20242444
125Rap1 signaling pathway_Homo sapiens_hsa040150.19981547
126Metabolic pathways_Homo sapiens_hsa011000.18436286

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