SLC25A40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC25A40 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.96326508
2mucosal-associated lymphoid tissue development (GO:0048537)4.18671030
3Peyers patch development (GO:0048541)4.18671030
4positive regulation of gamma-delta T cell activation (GO:0046645)4.15341867
5nuclear pore organization (GO:0006999)3.81331240
6regulation of nuclear cell cycle DNA replication (GO:0033262)3.81239589
7protein K6-linked ubiquitination (GO:0085020)3.79724060
8monoubiquitinated protein deubiquitination (GO:0035520)3.79571197
9kinetochore organization (GO:0051383)3.76193357
10IMP biosynthetic process (GO:0006188)3.71436163
11regulation of DNA endoreduplication (GO:0032875)3.68029532
12nuclear pore complex assembly (GO:0051292)3.64102621
13CENP-A containing nucleosome assembly (GO:0034080)3.64000471
14phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.62650560
15response to interleukin-15 (GO:0070672)3.62242281
16chromatin remodeling at centromere (GO:0031055)3.60032582
17neutrophil activation involved in immune response (GO:0002283)3.58162293
18regulation of centriole replication (GO:0046599)3.57420130
19regulation of B cell receptor signaling pathway (GO:0050855)3.50420105
20intra-S DNA damage checkpoint (GO:0031573)3.46650596
21regulation of helicase activity (GO:0051095)3.44058031
22kinetochore assembly (GO:0051382)3.42977896
23negative regulation of DNA-dependent DNA replication (GO:2000104)3.42206026
24cellular response to interleukin-15 (GO:0071350)3.37563520
25meiotic chromosome segregation (GO:0045132)3.37510424
26regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36900532
27regulation of mitotic spindle checkpoint (GO:1903504)3.36900532
28microtubule depolymerization (GO:0007019)3.36706497
29regulation of gamma-delta T cell differentiation (GO:0045586)3.35726071
30positive regulation of interleukin-17 production (GO:0032740)3.34494751
31natural killer cell differentiation (GO:0001779)3.32005465
32pore complex assembly (GO:0046931)3.29409454
33mismatch repair (GO:0006298)3.27299806
34sister chromatid segregation (GO:0000819)3.27243561
35positive regulation of granulocyte differentiation (GO:0030854)3.25891156
36maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.23539537
37regulation of gamma-delta T cell activation (GO:0046643)3.21276866
38somatic hypermutation of immunoglobulin genes (GO:0016446)3.19379637
39somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19379637
40peptidyl-lysine trimethylation (GO:0018023)3.18371214
41replication fork processing (GO:0031297)3.16342928
42DNA replication initiation (GO:0006270)3.11412128
43DNA catabolic process, exonucleolytic (GO:0000738)3.09029909
44mitotic sister chromatid cohesion (GO:0007064)3.06094607
45telomere maintenance via recombination (GO:0000722)3.03790644
46positive regulation of DNA-dependent DNA replication (GO:2000105)3.03348368
47positive regulation of B cell differentiation (GO:0045579)3.03134053
48regulation of memory T cell differentiation (GO:0043380)3.02418723
49nucleobase biosynthetic process (GO:0046112)3.01226170
50determination of adult lifespan (GO:0008340)3.00703338
51regulation of fever generation (GO:0031620)2.99486645
52IMP metabolic process (GO:0046040)2.98806598
53negative regulation of cell killing (GO:0031342)2.98475402
54negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.98475402
55leukocyte aggregation (GO:0070486)2.97732511
56cellular extravasation (GO:0045123)2.96424609
57telomere maintenance via semi-conservative replication (GO:0032201)2.93169997
58telomere maintenance (GO:0000723)2.90529692
59mitotic recombination (GO:0006312)2.88567456
60hepatocyte apoptotic process (GO:0097284)2.87161886
61telomere organization (GO:0032200)2.85289721
62sister chromatid cohesion (GO:0007062)2.85018282
63DNA integration (GO:0015074)2.84831562
64tRNA methylation (GO:0030488)2.84564674
65DNA replication-independent nucleosome organization (GO:0034724)2.84068823
66DNA replication-independent nucleosome assembly (GO:0006336)2.84068823
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.80987375
68positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.80987375
69positive regulation of mitotic sister chromatid separation (GO:1901970)2.80987375
70somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80681102
71somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80681102
72isotype switching (GO:0045190)2.80681102
73DNA strand renaturation (GO:0000733)2.78419687
74histone mRNA catabolic process (GO:0071044)2.78120639
75negative regulation of T cell mediated immunity (GO:0002710)2.77119436
76regulation of interleukin-17 production (GO:0032660)2.75847959
77DNA strand elongation involved in DNA replication (GO:0006271)2.75784669
78histone exchange (GO:0043486)2.75317605
79regulation of double-strand break repair via homologous recombination (GO:0010569)2.74898018
80neutrophil activation (GO:0042119)2.74762792
81definitive hemopoiesis (GO:0060216)2.74260607
82telomere maintenance via telomere lengthening (GO:0010833)2.74094983
83mitotic metaphase plate congression (GO:0007080)2.72183434
84DNA strand elongation (GO:0022616)2.72070402
85nucleotide-excision repair, DNA gap filling (GO:0006297)2.71374224
86negative regulation of histone methylation (GO:0031061)2.71029530
87regulation of histone H3-K27 methylation (GO:0061085)2.70733761
88response to X-ray (GO:0010165)2.70708533
89synapsis (GO:0007129)2.70555190
90regulation of DNA damage checkpoint (GO:2000001)2.69387015
91somatic recombination of immunoglobulin gene segments (GO:0016447)2.69305334
92regulation of B cell differentiation (GO:0045577)2.69119331
93purine nucleobase biosynthetic process (GO:0009113)2.68301397
94protein localization to kinetochore (GO:0034501)2.66625138
95regulation of sister chromatid segregation (GO:0033045)2.66472927
96regulation of mitotic sister chromatid separation (GO:0010965)2.66472927
97regulation of mitotic sister chromatid segregation (GO:0033047)2.66472927
98regulation of histone H3-K9 methylation (GO:0051570)2.66156409
99negative regulation of DNA recombination (GO:0045910)2.66014782
100polyketide metabolic process (GO:0030638)2.66000807
101doxorubicin metabolic process (GO:0044598)2.66000807
102daunorubicin metabolic process (GO:0044597)2.66000807
103RNA-dependent DNA replication (GO:0006278)2.64643083
104DNA topological change (GO:0006265)2.63481609
105DNA demethylation (GO:0080111)2.63325725
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.63053470
107protein localization to chromosome, centromeric region (GO:0071459)2.62105064
108B cell receptor signaling pathway (GO:0050853)2.62006416
109mitotic G2 DNA damage checkpoint (GO:0007095)2.61359706
110metaphase plate congression (GO:0051310)2.61040020
111regulation of chromatin silencing (GO:0031935)2.60294171
112regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59730236
113mitotic G2/M transition checkpoint (GO:0044818)2.59677653
114neural tube formation (GO:0001841)2.59650572
115DNA replication checkpoint (GO:0000076)2.58834167
116mitotic spindle checkpoint (GO:0071174)2.58759335
117mitotic nuclear envelope disassembly (GO:0007077)2.58264493
118ncRNA catabolic process (GO:0034661)2.57317142
119DNA duplex unwinding (GO:0032508)2.57268326
120positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.57224657
121telomere maintenance via telomerase (GO:0007004)2.56694178
122DNA geometric change (GO:0032392)2.56455974
123microtubule polymerization or depolymerization (GO:0031109)2.56119552
124histone H3-K9 modification (GO:0061647)2.55770039
125regulation of centrosome cycle (GO:0046605)2.52376186
126interkinetic nuclear migration (GO:0022027)2.51714523
127attachment of spindle microtubules to kinetochore (GO:0008608)2.51124518
128interferon-gamma production (GO:0032609)2.50885004
129recombinational repair (GO:0000725)2.49693472
130mast cell activation (GO:0045576)2.48591652
131positive regulation of histone methylation (GO:0031062)2.48235191
132mitotic sister chromatid segregation (GO:0000070)2.48214864
133spindle assembly checkpoint (GO:0071173)2.47507931
134mitotic spindle assembly checkpoint (GO:0007094)2.47479034
135histone H3-K9 methylation (GO:0051567)2.46939907
136deoxyribonucleotide biosynthetic process (GO:0009263)2.46591037
137regulation of sister chromatid cohesion (GO:0007063)2.46326985
138double-strand break repair via homologous recombination (GO:0000724)2.46264722
139regulation of DNA-dependent DNA replication (GO:0090329)2.46068317
140energy homeostasis (GO:0097009)2.44907707
141positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.44341844
142negative regulation of lymphocyte mediated immunity (GO:0002707)2.44111776
143fucose catabolic process (GO:0019317)2.44077202
144L-fucose metabolic process (GO:0042354)2.44077202
145L-fucose catabolic process (GO:0042355)2.44077202
146protein K48-linked deubiquitination (GO:0071108)2.44070084
147megakaryocyte development (GO:0035855)2.43945384
148positive regulation of interleukin-1 beta secretion (GO:0050718)2.43770616
149negative regulation of chromosome segregation (GO:0051985)2.43662435
150negative regulation of mitotic sister chromatid separation (GO:2000816)2.43423489
151negative regulation of sister chromatid segregation (GO:0033046)2.43423489
152negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.43423489
153negative regulation of mitotic sister chromatid segregation (GO:0033048)2.43423489
154paraxial mesoderm development (GO:0048339)2.41365580
155regulation of gene silencing (GO:0060968)2.41113990
156regulation of telomere maintenance via telomerase (GO:0032210)2.41007058
157histone H2A acetylation (GO:0043968)2.40647735
158regulation of heat generation (GO:0031650)2.40313485
159DNA unwinding involved in DNA replication (GO:0006268)2.40059981
160spindle checkpoint (GO:0031577)2.39946150
161regulation of mitotic metaphase/anaphase transition (GO:0030071)2.39727633
162DNA dealkylation (GO:0035510)2.39630668
163replicative senescence (GO:0090399)2.39220703
164somatic cell DNA recombination (GO:0016444)2.37138732
165somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.37138732
166regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.36920299
167regulation of chemokine secretion (GO:0090196)2.36912890
168somatic diversification of immunoglobulins (GO:0016445)2.36036872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.79234566
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.60443467
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.22838898
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.94120067
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.78424318
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.43765578
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42599063
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.37231766
9* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22330251
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.17616961
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.16962121
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.14776488
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07895010
14SCL_19346495_ChIP-Seq_HPC-7_Human2.04437892
15* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00973199
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98509457
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93938030
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.87587075
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.86358820
20ELK1_19687146_ChIP-ChIP_HELA_Human1.85851545
21FUS_26573619_Chip-Seq_HEK293_Human1.81530624
22* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80341898
23ER_23166858_ChIP-Seq_MCF-7_Human1.79908418
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79064987
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78531488
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77643228
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77328032
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75016092
29IGF1R_20145208_ChIP-Seq_DFB_Human1.73417733
30EWS_26573619_Chip-Seq_HEK293_Human1.72794389
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71029084
32MYB_26560356_Chip-Seq_TH2_Human1.69600934
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.66763921
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66632911
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66483680
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64866324
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64683565
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62933636
39VDR_22108803_ChIP-Seq_LS180_Human1.61580119
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61551996
41RUNX_20019798_ChIP-Seq_JUKART_Human1.61457565
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60916185
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57199115
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.56722061
45SPI1_23547873_ChIP-Seq_NB4_Human1.54358742
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.54100335
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53342944
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.53198677
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52769736
50* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51287861
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48161615
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.48001701
53* VDR_23849224_ChIP-Seq_CD4+_Human1.47049711
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47046783
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46169768
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45397392
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44795921
58GBX2_23144817_ChIP-Seq_PC3_Human1.44120491
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43856603
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43340883
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42208260
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41800029
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39601152
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39269660
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38915545
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.37991369
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37863457
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37793053
69SALL4_22934838_ChIP-ChIP_CD34+_Human1.33360598
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.31881754
71* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29288317
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.27548407
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26689589
74MYB_26560356_Chip-Seq_TH1_Human1.25693295
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24460908
76FOXP3_21729870_ChIP-Seq_TREG_Human1.23661996
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.23585993
78* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23536229
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23053040
80* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21676265
81STAT3_23295773_ChIP-Seq_U87_Human1.21590914
82GATA3_26560356_Chip-Seq_TH2_Human1.21104640
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20616025
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20414665
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19229324
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19182556
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18746688
88* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15513788
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15476624
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13566933
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13245319
92GATA3_27048872_Chip-Seq_THYMUS_Human1.13216315
93P300_19829295_ChIP-Seq_ESCs_Human1.12469547
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12105730
95GATA1_22025678_ChIP-Seq_K562_Human1.11635635
96VDR_24787735_ChIP-Seq_THP-1_Human1.11617005
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09789249
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.09113714
99* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08314947
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08280854
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08099407
102* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07549892
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07509587
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07311013
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05748179
106IRF8_21731497_ChIP-ChIP_J774_Mouse1.05694189
107AR_21572438_ChIP-Seq_LNCaP_Human1.05210286
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05030792
109* TCF4_23295773_ChIP-Seq_U87_Human1.04921796
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.04724427
111TAF15_26573619_Chip-Seq_HEK293_Human1.04475760
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.03852798
113* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03150858
114AR_21909140_ChIP-Seq_LNCAP_Human1.02904277
115SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02395854
116FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00991933
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00927233
118* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00616044
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.00308670
120ETS1_20019798_ChIP-Seq_JURKAT_Human0.99624303
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99482499
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98725775
123GATA3_26560356_Chip-Seq_TH1_Human0.97538783
124OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97200010
125CBP_20019798_ChIP-Seq_JUKART_Human0.97099108
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97099108
127SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96554583
128PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96529304
129PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96110082
130SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96016663
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95655814
132SPI1_23127762_ChIP-Seq_K562_Human0.95532076
133CMYC_18555785_Chip-Seq_ESCs_Mouse0.95184876
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95060639
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.93713424
136FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93320008
137SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92601086
138IRF1_19129219_ChIP-ChIP_H3396_Human0.92563598
139P53_22387025_ChIP-Seq_ESCs_Mouse0.91869830
140SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91736844
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90861692
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88310198
143OCT4_18555785_Chip-Seq_ESCs_Mouse0.87781499
144P300_18555785_Chip-Seq_ESCs_Mouse0.87594009
145NMYC_18555785_Chip-Seq_ESCs_Mouse0.86075383
146TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84635005
147EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.84392295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.97765418
2MP0005171_absent_coat_pigmentation3.73643321
3MP0010094_abnormal_chromosome_stability3.49462556
4MP0008057_abnormal_DNA_replication3.25033069
5MP0008058_abnormal_DNA_repair3.18822001
6MP0003693_abnormal_embryo_hatching3.11995424
7MP0003111_abnormal_nucleus_morphology2.95227200
8MP0001188_hyperpigmentation2.92905429
9MP0003787_abnormal_imprinting2.70394725
10MP0002396_abnormal_hematopoietic_system2.66010787
11MP0005174_abnormal_tail_pigmentation2.64699056
12MP0008007_abnormal_cellular_replicative2.64090178
13MP0003941_abnormal_skin_development2.62806701
14MP0003077_abnormal_cell_cycle2.48715163
15MP0003806_abnormal_nucleotide_metabolis2.33991693
16MP0006292_abnormal_olfactory_placode2.09447852
17MP0005075_abnormal_melanosome_morpholog2.07608687
18MP0004957_abnormal_blastocyst_morpholog2.05066637
19MP0002095_abnormal_skin_pigmentation1.93326540
20MP0001501_abnormal_sleep_pattern1.92576870
21MP0003656_abnormal_erythrocyte_physiolo1.89461354
22MP0000685_abnormal_immune_system1.81704556
23MP0003121_genomic_imprinting1.81201598
24MP0003436_decreased_susceptibility_to1.79728641
25MP0003724_increased_susceptibility_to1.74010435
26MP0000015_abnormal_ear_pigmentation1.71881201
27MP0005671_abnormal_response_to1.70809996
28MP0010352_gastrointestinal_tract_polyps1.69760330
29MP0005310_abnormal_salivary_gland1.68873900
30MP0009697_abnormal_copulation1.67942306
31MP0002009_preneoplasia1.67122427
32MP0003786_premature_aging1.64761578
33MP0005000_abnormal_immune_tolerance1.62636198
34MP0008877_abnormal_DNA_methylation1.61907888
35MP0005464_abnormal_platelet_physiology1.55493578
36MP0002419_abnormal_innate_immunity1.53113964
37MP0001986_abnormal_taste_sensitivity1.52659401
38MP0001873_stomach_inflammation1.46950373
39MP0010307_abnormal_tumor_latency1.46943180
40MP0000490_abnormal_crypts_of1.44306987
41MP0003646_muscle_fatigue1.44025960
42MP0008932_abnormal_embryonic_tissue1.43475502
43MP0009785_altered_susceptibility_to1.42098625
44MP0002277_abnormal_respiratory_mucosa1.41590763
45MP0001293_anophthalmia1.34775389
46MP0003279_aneurysm1.34704069
47MP0003763_abnormal_thymus_physiology1.31472163
48MP0000465_gastrointestinal_hemorrhage1.29561896
49MP0005025_abnormal_response_to1.29546625
50MP0001835_abnormal_antigen_presentation1.25325331
51MP0000350_abnormal_cell_proliferation1.24905805
52MP0000516_abnormal_urinary_system1.24441496
53MP0005367_renal/urinary_system_phenotyp1.24441496
54MP0004381_abnormal_hair_follicle1.23751610
55MP0000569_abnormal_digit_pigmentation1.22986763
56MP0002405_respiratory_system_inflammati1.22216414
57MP0002075_abnormal_coat/hair_pigmentati1.15432388
58MP0002638_abnormal_pupillary_reflex1.13935331
59MP0000371_diluted_coat_color1.13240176
60MP0003890_abnormal_embryonic-extraembry1.12680387
61MP0001186_pigmentation_phenotype1.11297408
62MP0003172_abnormal_lysosome_physiology1.10804403
63MP0002166_altered_tumor_susceptibility1.10525717
64MP0002160_abnormal_reproductive_system1.08088436
65MP0001851_eye_inflammation1.07618700
66MP0003123_paternal_imprinting1.03658836
67MP0003315_abnormal_perineum_morphology1.03139546
68MP0003183_abnormal_peptide_metabolism1.02749458
69MP0000858_altered_metastatic_potential1.02153196
70MP0009278_abnormal_bone_marrow1.00946923
71MP0003566_abnormal_cell_adhesion1.00193303
72MP0003303_peritoneal_inflammation0.99547060
73MP0009046_muscle_twitch0.99023769
74MP0002006_tumorigenesis0.98434119
75MP0005646_abnormal_pituitary_gland0.97623554
76MP0002398_abnormal_bone_marrow0.93899608
77MP0002938_white_spotting0.93798593
78MP0002148_abnormal_hypersensitivity_rea0.93698868
79MP0001984_abnormal_olfaction0.93427863
80MP0010234_abnormal_vibrissa_follicle0.92966819
81MP0003300_gastrointestinal_ulcer0.92569358
82MP0002163_abnormal_gland_morphology0.92063135
83MP0000703_abnormal_thymus_morphology0.91563615
84MP0003943_abnormal_hepatobiliary_system0.91529661
85MP0001119_abnormal_female_reproductive0.91519426
86MP0005389_reproductive_system_phenotype0.91135698
87MP0009764_decreased_sensitivity_to0.90034352
88MP0005266_abnormal_metabolism0.89253369
89MP0004808_abnormal_hematopoietic_stem0.88528292
90MP0001800_abnormal_humoral_immune0.88325978
91MP0008872_abnormal_physiological_respon0.87650191
92MP0005084_abnormal_gallbladder_morpholo0.87470572
93MP0000689_abnormal_spleen_morphology0.87230708
94MP0002722_abnormal_immune_system0.86537734
95MP0010678_abnormal_skin_adnexa0.86055782
96MP0002132_abnormal_respiratory_system0.85596082
97MP0000313_abnormal_cell_death0.83064183
98MP0001286_abnormal_eye_development0.83007870
99MP0001845_abnormal_inflammatory_respons0.82250125
100MP0005076_abnormal_cell_differentiation0.82196229
101MP0002452_abnormal_antigen_presenting0.81897240
102MP0002019_abnormal_tumor_incidence0.78347162
103MP0001545_abnormal_hematopoietic_system0.77633389
104MP0005397_hematopoietic_system_phenotyp0.77633389
105MP0000372_irregular_coat_pigmentation0.77563046
106MP0002877_abnormal_melanocyte_morpholog0.77444910
107MP0003567_abnormal_fetal_cardiomyocyte0.77329644
108MP0001819_abnormal_immune_cell0.75801670
109MP0003718_maternal_effect0.75400000
110MP0002420_abnormal_adaptive_immunity0.75392364
111MP0005409_darkened_coat_color0.75383068
112MP0000427_abnormal_hair_cycle0.75087801
113MP0006082_CNS_inflammation0.74995411
114MP0006035_abnormal_mitochondrial_morpho0.73819664
115MP0004043_abnormal_pH_regulation0.73603423
116MP0002210_abnormal_sex_determination0.72571265
117MP0002086_abnormal_extraembryonic_tissu0.71462391
118MP0000432_abnormal_head_morphology0.71073620
119MP0003878_abnormal_ear_physiology0.70365606
120MP0005377_hearing/vestibular/ear_phenot0.70365606
121MP0002723_abnormal_immune_serum0.70340231
122MP0004197_abnormal_fetal_growth/weight/0.70216237
123MP0001919_abnormal_reproductive_system0.69976293
124MP0005647_abnormal_sex_gland0.69885320
125MP0006072_abnormal_retinal_apoptosis0.69855523
126MP0001929_abnormal_gametogenesis0.69620379
127MP0001529_abnormal_vocalization0.68101000
128MP0004133_heterotaxia0.67831965
129MP0001764_abnormal_homeostasis0.67622291
130MP0003221_abnormal_cardiomyocyte_apopto0.67285208
131MP0000383_abnormal_hair_follicle0.67200312
132MP0000566_synostosis0.66594583
133MP0001672_abnormal_embryogenesis/_devel0.65810386
134MP0005380_embryogenesis_phenotype0.65810386
135MP0001790_abnormal_immune_system0.65538651
136MP0005387_immune_system_phenotype0.65538651
137MP0001175_abnormal_lung_morphology0.64227644
138MP0001853_heart_inflammation0.64149868
139MP0009765_abnormal_xenobiotic_induced0.63380594
140MP0003045_fibrosis0.63121671
141MP0002751_abnormal_autonomic_nervous0.62401697
142MP0000716_abnormal_immune_system0.62016447
143MP0002109_abnormal_limb_morphology0.60466117
144MP0002429_abnormal_blood_cell0.60248871
145MP0004147_increased_porphyrin_level0.58350290
146MP0001270_distended_abdomen0.58171696
147MP0002085_abnormal_embryonic_tissue0.57562945
148MP0010155_abnormal_intestine_physiology0.57147264
149MP0001145_abnormal_male_reproductive0.56464458
150MP0004134_abnormal_chest_morphology0.54893879

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.74901266
2Chromsome breakage (HP:0040012)5.56389196
3Abnormality of chromosome stability (HP:0003220)3.70521099
4Birth length less than 3rd percentile (HP:0003561)3.56405402
5Ectopic kidney (HP:0000086)3.54162794
6Abnormality of the preputium (HP:0100587)3.33499457
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.31410294
8Meckel diverticulum (HP:0002245)3.25893549
9Combined immunodeficiency (HP:0005387)3.21951305
10Severe combined immunodeficiency (HP:0004430)3.20215874
11White forelock (HP:0002211)3.12143653
12Abnormality of the ileum (HP:0001549)3.07003451
13Abnormality of the renal collecting system (HP:0004742)3.06607008
14Supernumerary spleens (HP:0009799)3.01299858
15Agnosia (HP:0010524)2.90015765
16Stomatitis (HP:0010280)2.87560094
17Patchy hypopigmentation of hair (HP:0011365)2.84274230
18Clubbing of toes (HP:0100760)2.80564176
19Encephalitis (HP:0002383)2.78883541
20Abnormality of DNA repair (HP:0003254)2.77530452
21Duplicated collecting system (HP:0000081)2.77352670
22Retrobulbar optic neuritis (HP:0100654)2.76020716
23Optic neuritis (HP:0100653)2.76020716
24Premature graying of hair (HP:0002216)2.75777747
25Volvulus (HP:0002580)2.73478303
26Papillary thyroid carcinoma (HP:0002895)2.73234521
27Myelodysplasia (HP:0002863)2.71636500
28T lymphocytopenia (HP:0005403)2.69939911
29Abnormality of the labia minora (HP:0012880)2.56724926
30Gaze-evoked nystagmus (HP:0000640)2.54609775
31Abnormality of B cell number (HP:0010975)2.51698350
32Duodenal stenosis (HP:0100867)2.51657330
33Small intestinal stenosis (HP:0012848)2.51657330
34Panhypogammaglobulinemia (HP:0003139)2.51021000
35Abnormal hair whorl (HP:0010721)2.49663225
36Bone marrow hypocellularity (HP:0005528)2.49363740
37Keratoconjunctivitis sicca (HP:0001097)2.48625121
38Prostate neoplasm (HP:0100787)2.47030182
39B lymphocytopenia (HP:0010976)2.46790159
40Recurrent cutaneous fungal infections (HP:0011370)2.45799493
41Chronic mucocutaneous candidiasis (HP:0002728)2.45799493
42Recurrent fungal infections (HP:0002841)2.44846155
43Fatigue (HP:0012378)2.42990142
44Abnormality of the carotid arteries (HP:0005344)2.42575159
45Central scotoma (HP:0000603)2.42316811
46Short middle phalanx of the 5th finger (HP:0004220)2.41724745
47Abnormality of T cell number (HP:0011839)2.41059027
48Abnormality of T cells (HP:0002843)2.40546056
49Keratoconjunctivitis (HP:0001096)2.39409141
50Thyroiditis (HP:0100646)2.38011553
51Abnormality of T cell physiology (HP:0011840)2.29410355
52Renal cortical cysts (HP:0000803)2.28135845
53Recurrent viral infections (HP:0004429)2.25043611
54IgG deficiency (HP:0004315)2.24822388
55Absent thumb (HP:0009777)2.24515278
56Thyroid carcinoma (HP:0002890)2.24202156
57Lip pit (HP:0100267)2.23615967
58Recurrent abscess formation (HP:0002722)2.21780021
59IgM deficiency (HP:0002850)2.17542817
60Nephroblastoma (Wilms tumor) (HP:0002667)2.17198199
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.14662842
62Febrile seizures (HP:0002373)2.11666831
63Abnormality of the columella (HP:0009929)2.11591698
64Recurrent bacterial skin infections (HP:0005406)2.07895986
65Aplastic anemia (HP:0001915)2.06717548
66Gonadotropin excess (HP:0000837)2.06221822
67Rhabdomyosarcoma (HP:0002859)2.05854062
68Abnormality of the duodenum (HP:0002246)2.04130216
69Chronic diarrhea (HP:0002028)2.03861881
70Abnormal lung lobation (HP:0002101)2.03782706
71Embryonal renal neoplasm (HP:0011794)2.02132880
72Abnormality of the nasal septum (HP:0000419)2.01821162
73Abnormal trabecular bone morphology (HP:0100671)2.01190966
74Acute lymphatic leukemia (HP:0006721)1.99929076
75Medulloblastoma (HP:0002885)1.99285962
76Sloping forehead (HP:0000340)1.98307829
77Selective tooth agenesis (HP:0001592)1.97873986
78Colon cancer (HP:0003003)1.96869870
79Pancreatic fibrosis (HP:0100732)1.96566518
80Orchitis (HP:0100796)1.95934280
81Eczematoid dermatitis (HP:0000976)1.95820060
82Impulsivity (HP:0100710)1.95666735
83Myositis (HP:0100614)1.94693111
84Meningitis (HP:0001287)1.94598546
85True hermaphroditism (HP:0010459)1.94267333
86Abnormality of eosinophils (HP:0001879)1.91574900
87Abnormality of lateral ventricle (HP:0030047)1.91388883
88Arterial thrombosis (HP:0004420)1.90975058
89Inflammation of the large intestine (HP:0002037)1.90770094
90Lower limb hyperreflexia (HP:0002395)1.89718181
91Rough bone trabeculation (HP:0100670)1.88869995
92Aplasia/Hypoplasia of the sternum (HP:0006714)1.88598085
93Cafe-au-lait spot (HP:0000957)1.87954034
94Long clavicles (HP:0000890)1.87393881
95Fair hair (HP:0002286)1.87289814
96Methylmalonic acidemia (HP:0002912)1.86712186
97Spinal muscular atrophy (HP:0007269)1.86244141
98Absent radius (HP:0003974)1.85439183
99Asplenia (HP:0001746)1.84208303
100Submucous cleft hard palate (HP:0000176)1.83519342
101Limb hypertonia (HP:0002509)1.83373592
102Reticulocytopenia (HP:0001896)1.83171383
103Abnormality of methionine metabolism (HP:0010901)1.83166469
104Pheochromocytoma (HP:0002666)1.83157688
105Broad face (HP:0000283)1.82522685
106Prominent nose (HP:0000448)1.82229598
107Amaurosis fugax (HP:0100576)1.81675836
108Vasculitis (HP:0002633)1.81489338
109Short thumb (HP:0009778)1.81384228
110Aplasia involving forearm bones (HP:0009822)1.81309006
111Absent forearm bone (HP:0003953)1.81309006
112Dyschromatopsia (HP:0007641)1.81216758
11311 pairs of ribs (HP:0000878)1.80522235
114Gastrointestinal inflammation (HP:0004386)1.79158213
115Pancreatic cysts (HP:0001737)1.78662809
116Basal cell carcinoma (HP:0002671)1.77978315
117Astigmatism (HP:0000483)1.77663431
118Abnormality of the periventricular white matter (HP:0002518)1.76847104
119Hypochromic microcytic anemia (HP:0004840)1.76224661
120Aortic regurgitation (HP:0001659)1.76153639
121Abnormality of the renal cortex (HP:0011035)1.76128881
122Mediastinal lymphadenopathy (HP:0100721)1.75887362
123Tubulointerstitial nephritis (HP:0001970)1.75851447
124Abnormality of chromosome segregation (HP:0002916)1.75747059
125Abnormality of the incisor (HP:0000676)1.74788258
126Progressive inability to walk (HP:0002505)1.74557136
127Intestinal atresia (HP:0011100)1.74544249
128Acute hepatic failure (HP:0006554)1.73700250
129Granulocytopenia (HP:0001913)1.73563983
130Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.73366949
131Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.73356428
132Constricted visual fields (HP:0001133)1.73110617
133Acanthocytosis (HP:0001927)1.72467024
134Neoplasm of the oral cavity (HP:0100649)1.72333915
135Triphalangeal thumb (HP:0001199)1.71868001
136Preaxial hand polydactyly (HP:0001177)1.71335824
137Distal lower limb muscle weakness (HP:0009053)1.71092895
138Autoimmune hemolytic anemia (HP:0001890)1.70878471
139Albinism (HP:0001022)1.70745161
140Heterochromia iridis (HP:0001100)1.68143606
141Hypergonadotropic hypogonadism (HP:0000815)1.67762227
142Septo-optic dysplasia (HP:0100842)1.66983844
143Optic nerve coloboma (HP:0000588)1.66776646
144Neutropenia (HP:0001875)1.66622553
145Neoplasm of the small intestine (HP:0100833)1.66247426
146Dysmetric saccades (HP:0000641)1.66051636
147Truncal obesity (HP:0001956)1.65310253
148Clitoromegaly (HP:0000057)1.64894384
149Osteomalacia (HP:0002749)1.63890101
150Abnormal number of incisors (HP:0011064)1.63523094
151Poor head control (HP:0002421)1.63019196
152Stomach cancer (HP:0012126)1.62698219
153Recurrent skin infections (HP:0001581)1.62669905
154Nephrogenic diabetes insipidus (HP:0009806)1.62538998
155Acute myeloid leukemia (HP:0004808)1.62485688
156Abnormality of the prostate (HP:0008775)1.62315993
157Hypoplasia of the thymus (HP:0000778)1.62120490
158Hypothermia (HP:0002045)1.61569319
159Metaphyseal dysplasia (HP:0100255)1.61479032
160Patellar aplasia (HP:0006443)1.61235796
161Lymphoma (HP:0002665)1.61218284
162Leukocytosis (HP:0001974)1.60533149
163Tongue fasciculations (HP:0001308)1.60409106
164Duplication of thumb phalanx (HP:0009942)1.59910963
165Poikilocytosis (HP:0004447)1.59833436
166Abnormality of incisor morphology (HP:0011063)1.59005147
167Hypoplasia of the fovea (HP:0007750)1.58744573
168Aplasia/Hypoplasia of the fovea (HP:0008060)1.58744573
169Congenital primary aphakia (HP:0007707)1.58186875
170Abnormal auditory evoked potentials (HP:0006958)1.58142777
171Type 2 muscle fiber atrophy (HP:0003554)1.57687300
172Aganglionic megacolon (HP:0002251)1.57493463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.88181606
2ZAK3.16846582
3MKNK22.96848823
4RIPK42.90347410
5CDK82.81597300
6AKT32.67307744
7TXK2.55667710
8MAP2K72.41220456
9CASK2.37563979
10MKNK12.27830104
11WEE12.09498970
12SRPK12.09366068
13CDC72.03166875
14VRK11.87930941
15TEC1.84090780
16MAP3K141.74193765
17ATR1.66285822
18EIF2AK11.65270461
19TSSK61.60012800
20FLT31.58563609
21PLK41.57614107
22YES11.57560933
23BCR1.57050576
24IRAK31.54992692
25PLK31.52441985
26CAMKK21.52115246
27EIF2AK21.52112284
28ALK1.41613587
29SGK21.40961111
30BRD41.40286506
31FRK1.39109481
32ADRBK21.37252367
33MAP3K131.36444444
34TNIK1.36094922
35EPHA21.32602866
36CHEK21.28503075
37PASK1.27876804
38NUAK11.25754676
39CDK121.25059177
40SIK31.22696368
41CDK31.21812606
42JAK31.21566117
43TTK1.20924443
44STK38L1.13918613
45KSR21.12663154
46PLK11.12384494
47PDK21.12281949
48FES1.12162574
49SYK1.11758653
50ATM1.09989653
51CDK61.09950916
52TRIM281.09143887
53RAF11.08418196
54ACVR1B1.07724336
55MAP3K121.07438978
56PIK3CG1.06094597
57MUSK1.05214333
58MST41.04227348
59AURKB1.04127477
60JAK11.02816351
61EIF2AK31.02217156
62BRSK21.01276189
63STK30.98088095
64NEK20.97259703
65KSR10.96551214
66BLK0.96149695
67PLK20.95034382
68HCK0.94825165
69ERBB30.94010659
70CDK70.91621622
71MAP4K20.90601211
72BUB10.90105454
73STK40.89541648
74NEK60.89056365
75GRK60.88494022
76MELK0.87770629
77JAK20.86504804
78TAOK20.83912416
79MAP3K40.83875890
80PRPF4B0.82329510
81RPS6KA40.82139609
82CDK90.81780987
83IKBKB0.81703071
84CDK40.80603649
85TLK10.80161664
86CCNB10.79866056
87RPS6KB10.79620062
88NEK10.77138991
89CHEK10.76413864
90IRAK40.76314005
91PIM10.75764328
92MAPK70.75188473
93MAP4K10.75030897
94BMPR1B0.74814471
95RPS6KB20.72573096
96BMPR20.70302765
97NEK90.70119922
98SGK30.69320832
99ITK0.67618270
100OXSR10.66754690
101SIK20.65096436
102DYRK30.64163243
103MAPK130.62973692
104TNK20.62109298
105KIT0.61203769
106BRAF0.60836496
107STK160.60128761
108MET0.59290102
109BTK0.58885853
110TRPM70.57378646
111PBK0.56868272
112TGFBR10.56721032
113MARK30.56014765
114CDK20.55801721
115STK390.55373960
116TYK20.54633095
117CSNK1A1L0.54297269
118IKBKE0.53464139
119WNK10.49569362
120STK240.49360525
121LYN0.49285162
122LCK0.48796085
123FGFR30.48243343
124PIK3CA0.47900799
125STK100.47175261
126IRAK10.46758937
127MAPK110.46227798
128ZAP700.46166107
129CSNK2A10.44902612
130CDK10.44703105
131MAP3K60.44633395
132MAP3K80.44550981
133PINK10.44268751
134PRKCQ0.44183511
135RPS6KA50.43788944
136FGR0.43391922
137CSF1R0.42395130
138PDK10.42037344
139MAPK140.40097861
140CHUK0.39495912
141DAPK10.39313866
142CSNK2A20.37701806
143TAF10.37094379
144PRKDC0.36028619
145NME20.36028283

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.80805200
2Non-homologous end-joining_Homo sapiens_hsa034503.58802991
3Homologous recombination_Homo sapiens_hsa034403.52925741
4DNA replication_Homo sapiens_hsa030303.45673420
5Fanconi anemia pathway_Homo sapiens_hsa034603.43663352
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07976183
7Nucleotide excision repair_Homo sapiens_hsa034202.60046582
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.25635947
9Cell cycle_Homo sapiens_hsa041102.17270038
10Basal transcription factors_Homo sapiens_hsa030222.14828863
11Base excision repair_Homo sapiens_hsa034102.14497980
12RNA polymerase_Homo sapiens_hsa030201.99112380
13One carbon pool by folate_Homo sapiens_hsa006701.96502543
14RNA transport_Homo sapiens_hsa030131.93838223
15RNA degradation_Homo sapiens_hsa030181.85020130
16Spliceosome_Homo sapiens_hsa030401.79017533
17p53 signaling pathway_Homo sapiens_hsa041151.71648932
18B cell receptor signaling pathway_Homo sapiens_hsa046621.69247317
19Pyrimidine metabolism_Homo sapiens_hsa002401.63991722
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60569585
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57239673
22Allograft rejection_Homo sapiens_hsa053301.45699423
23Osteoclast differentiation_Homo sapiens_hsa043801.39463140
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35411727
25Propanoate metabolism_Homo sapiens_hsa006401.32117708
26Herpes simplex infection_Homo sapiens_hsa051681.28968437
27Hematopoietic cell lineage_Homo sapiens_hsa046401.26258287
28Tuberculosis_Homo sapiens_hsa051521.24135357
29Acute myeloid leukemia_Homo sapiens_hsa052211.22605863
30Systemic lupus erythematosus_Homo sapiens_hsa053221.21724963
31Measles_Homo sapiens_hsa051621.20005119
32Non-small cell lung cancer_Homo sapiens_hsa052231.19497462
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13307968
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.12304458
35Graft-versus-host disease_Homo sapiens_hsa053321.11931951
36Oocyte meiosis_Homo sapiens_hsa041141.11379478
37Primary immunodeficiency_Homo sapiens_hsa053401.11160284
38Type I diabetes mellitus_Homo sapiens_hsa049401.10578155
39Proteasome_Homo sapiens_hsa030501.08997003
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08438203
41Purine metabolism_Homo sapiens_hsa002301.06986851
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05519552
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03516672
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03208569
45Autoimmune thyroid disease_Homo sapiens_hsa053201.01399349
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97954505
47Platelet activation_Homo sapiens_hsa046110.95662625
48Epstein-Barr virus infection_Homo sapiens_hsa051690.90901953
49mRNA surveillance pathway_Homo sapiens_hsa030150.89920378
50Chemokine signaling pathway_Homo sapiens_hsa040620.89344101
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87261477
52Other glycan degradation_Homo sapiens_hsa005110.87109572
53Legionellosis_Homo sapiens_hsa051340.87025399
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.85785517
55mTOR signaling pathway_Homo sapiens_hsa041500.85772246
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85744997
57Viral carcinogenesis_Homo sapiens_hsa052030.85039054
58Olfactory transduction_Homo sapiens_hsa047400.85009349
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82277119
60Chronic myeloid leukemia_Homo sapiens_hsa052200.82244742
61Ribosome_Homo sapiens_hsa030100.82034893
62Morphine addiction_Homo sapiens_hsa050320.77974322
63Prolactin signaling pathway_Homo sapiens_hsa049170.76595495
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.75188424
65Dorso-ventral axis formation_Homo sapiens_hsa043200.75066785
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74667480
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74241945
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70969223
69Antigen processing and presentation_Homo sapiens_hsa046120.69642340
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69002935
71HTLV-I infection_Homo sapiens_hsa051660.67897171
72Nitrogen metabolism_Homo sapiens_hsa009100.67795813
73Rheumatoid arthritis_Homo sapiens_hsa053230.67510174
74Melanoma_Homo sapiens_hsa052180.67451046
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66789595
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.66308348
77Influenza A_Homo sapiens_hsa051640.65796469
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64710221
79Hepatitis B_Homo sapiens_hsa051610.64557422
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64525787
81Long-term potentiation_Homo sapiens_hsa047200.63948359
82Colorectal cancer_Homo sapiens_hsa052100.63270213
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61244227
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60197694
85Alcoholism_Homo sapiens_hsa050340.59818513
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58676089
87Toxoplasmosis_Homo sapiens_hsa051450.57730875
88Arachidonic acid metabolism_Homo sapiens_hsa005900.57382087
89TGF-beta signaling pathway_Homo sapiens_hsa043500.56313734
90Butanoate metabolism_Homo sapiens_hsa006500.55969925
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54672628
92MicroRNAs in cancer_Homo sapiens_hsa052060.54488392
93Apoptosis_Homo sapiens_hsa042100.53649662
94ABC transporters_Homo sapiens_hsa020100.52635412
95Choline metabolism in cancer_Homo sapiens_hsa052310.52048076
96Asthma_Homo sapiens_hsa053100.51889490
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49655903
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48491343
99Malaria_Homo sapiens_hsa051440.47730338
100TNF signaling pathway_Homo sapiens_hsa046680.47081453
101GABAergic synapse_Homo sapiens_hsa047270.45822964
102Glioma_Homo sapiens_hsa052140.44086926
103Pathways in cancer_Homo sapiens_hsa052000.43763574
104Inositol phosphate metabolism_Homo sapiens_hsa005620.43682475
105Staphylococcus aureus infection_Homo sapiens_hsa051500.43249747
106Pancreatic secretion_Homo sapiens_hsa049720.42221222
107Basal cell carcinoma_Homo sapiens_hsa052170.42044146
108Small cell lung cancer_Homo sapiens_hsa052220.40483650
109Nicotine addiction_Homo sapiens_hsa050330.40077509
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38743995
111FoxO signaling pathway_Homo sapiens_hsa040680.34534468
112Leishmaniasis_Homo sapiens_hsa051400.34441498
113Adherens junction_Homo sapiens_hsa045200.30317940
114African trypanosomiasis_Homo sapiens_hsa051430.30152255
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29731544
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28833952
117Prostate cancer_Homo sapiens_hsa052150.28578216
118Wnt signaling pathway_Homo sapiens_hsa043100.27622419
119Sphingolipid metabolism_Homo sapiens_hsa006000.27501889
120Taste transduction_Homo sapiens_hsa047420.26331406
121Hippo signaling pathway_Homo sapiens_hsa043900.26302136
122Selenocompound metabolism_Homo sapiens_hsa004500.24975129
123T cell receptor signaling pathway_Homo sapiens_hsa046600.24823026
124Hepatitis C_Homo sapiens_hsa051600.24530311
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24178585
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23434123
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.21303363
128Pancreatic cancer_Homo sapiens_hsa052120.21166096
129Shigellosis_Homo sapiens_hsa051310.20948818
130Protein export_Homo sapiens_hsa030600.20800142
131Phagosome_Homo sapiens_hsa041450.20515378
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20264266

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