SLC25A41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC25A41 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.33694937
2acrosome reaction (GO:0007340)6.00537985
3purine nucleobase biosynthetic process (GO:0009113)5.87931845
4DNA deamination (GO:0045006)5.48572679
5ribosome assembly (GO:0042255)5.40629576
6behavioral response to nicotine (GO:0035095)5.25040615
7protein polyglutamylation (GO:0018095)5.24406537
8nucleobase biosynthetic process (GO:0046112)5.18482761
9mitotic metaphase plate congression (GO:0007080)4.89192404
10cellular ketone body metabolic process (GO:0046950)4.75920662
11rRNA modification (GO:0000154)4.62558677
12single strand break repair (GO:0000012)4.59571411
13proteasome assembly (GO:0043248)4.55102795
14transcription elongation from RNA polymerase III promoter (GO:0006385)4.48043250
15termination of RNA polymerase III transcription (GO:0006386)4.48043250
16synaptonemal complex assembly (GO:0007130)4.44686425
17folic acid metabolic process (GO:0046655)4.40267580
18ribosome biogenesis (GO:0042254)4.35368257
19DNA replication checkpoint (GO:0000076)4.20109565
20ketone body metabolic process (GO:1902224)4.18728463
21plasma membrane fusion (GO:0045026)4.18510286
22folic acid transport (GO:0015884)4.16640221
23calcium ion-dependent exocytosis (GO:0017156)4.13610842
24synaptonemal complex organization (GO:0070193)4.13401334
25regulation of spindle organization (GO:0090224)4.13189974
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.05691346
27anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.03142122
28epithelial cilium movement (GO:0003351)4.01074515
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.99243794
30sperm-egg recognition (GO:0035036)3.99110185
31sperm motility (GO:0030317)3.96965891
32termination of RNA polymerase I transcription (GO:0006363)3.95606360
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.94740374
34vitamin transmembrane transport (GO:0035461)3.94384515
35guanosine-containing compound biosynthetic process (GO:1901070)3.92736283
36transcription elongation from RNA polymerase I promoter (GO:0006362)3.88725078
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.87648072
38meiosis I (GO:0007127)3.87260431
39centriole replication (GO:0007099)3.86901289
407-methylguanosine mRNA capping (GO:0006370)3.85367139
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.82096367
42regulation of microtubule-based movement (GO:0060632)3.80999116
43sperm capacitation (GO:0048240)3.79150420
44formation of translation preinitiation complex (GO:0001731)3.78676708
45transcription from RNA polymerase I promoter (GO:0006360)3.78647584
46male meiosis I (GO:0007141)3.77361106
47spermatid development (GO:0007286)3.76461623
48binding of sperm to zona pellucida (GO:0007339)3.73836827
497-methylguanosine RNA capping (GO:0009452)3.70985323
50RNA capping (GO:0036260)3.70985323
51positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.69097425
52fusion of sperm to egg plasma membrane (GO:0007342)3.67773178
53cell wall macromolecule catabolic process (GO:0016998)3.64477888
54cell wall macromolecule metabolic process (GO:0044036)3.64477888
55metaphase plate congression (GO:0051310)3.63546053
56reproduction (GO:0000003)3.62476794
57blastocyst development (GO:0001824)3.61453557
58lung-associated mesenchyme development (GO:0060484)3.61121132
59ATP synthesis coupled proton transport (GO:0015986)3.58023023
60energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58023023
61ribonucleoprotein complex biogenesis (GO:0022613)3.55637562
62cell-cell recognition (GO:0009988)3.55575841
63spliceosomal snRNP assembly (GO:0000387)3.55166758
64maturation of SSU-rRNA (GO:0030490)3.55082675
65negative regulation of ligase activity (GO:0051352)3.54308429
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54308429
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.52733070
68monoubiquitinated protein deubiquitination (GO:0035520)3.52733016
69maturation of 5.8S rRNA (GO:0000460)3.52146752
70protein K6-linked ubiquitination (GO:0085020)3.48841826
71acrosome assembly (GO:0001675)3.48063787
72microtubule polymerization or depolymerization (GO:0031109)3.46593458
73positive regulation of ligase activity (GO:0051351)3.45779755
74piRNA metabolic process (GO:0034587)3.45709925
75axonemal dynein complex assembly (GO:0070286)3.45289532
76rRNA processing (GO:0006364)3.45049638
77microtubule depolymerization (GO:0007019)3.44532312
78multicellular organism reproduction (GO:0032504)3.44296901
79GMP metabolic process (GO:0046037)3.42665005
80positive regulation of chromosome segregation (GO:0051984)3.41849374
81protein-cofactor linkage (GO:0018065)3.39647152
82pantothenate metabolic process (GO:0015939)3.38990313
83rRNA metabolic process (GO:0016072)3.38986196
84gamma-aminobutyric acid transport (GO:0015812)3.38400125
85transcription initiation from RNA polymerase I promoter (GO:0006361)3.38113834
86histone exchange (GO:0043486)3.37461767
87regulation of cellular amino acid metabolic process (GO:0006521)3.36189675
88regulation of ubiquitin-protein transferase activity (GO:0051438)3.36185649
89spermatid nucleus differentiation (GO:0007289)3.35926010
90protein localization to chromosome, centromeric region (GO:0071459)3.35712639
91ribosomal large subunit biogenesis (GO:0042273)3.35139381
92amino acid salvage (GO:0043102)3.34484337
93L-methionine salvage (GO:0071267)3.34484337
94L-methionine biosynthetic process (GO:0071265)3.34484337
95neurofilament cytoskeleton organization (GO:0060052)3.32551895
96male meiosis (GO:0007140)3.30600776
97rRNA methylation (GO:0031167)3.29877262
98positive regulation of action potential (GO:0045760)3.29489779
99establishment of protein localization to Golgi (GO:0072600)3.29066176
100regulation of chromosome segregation (GO:0051983)3.28150025
101nephron epithelium morphogenesis (GO:0072088)3.27672798
102nephron tubule morphogenesis (GO:0072078)3.27672798
103detection of light stimulus involved in visual perception (GO:0050908)3.27544893
104detection of light stimulus involved in sensory perception (GO:0050962)3.27544893
105establishment of protein localization to mitochondrial membrane (GO:0090151)3.26975537
106protein targeting to Golgi (GO:0000042)3.25882907
107regulation of translation in response to stress (GO:0043555)3.25597801
108cilium movement (GO:0003341)3.24597497
109RNA destabilization (GO:0050779)3.23701997
110DNA-templated transcription, elongation (GO:0006354)3.23617338
111spindle checkpoint (GO:0031577)3.23452228
112mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.22458700
113regulation of cilium movement (GO:0003352)3.22201790
114transcription elongation from RNA polymerase II promoter (GO:0006368)3.22139307
115spermatogenesis (GO:0007283)3.20754760
116male gamete generation (GO:0048232)3.20503450
117cilium or flagellum-dependent cell motility (GO:0001539)3.19524238
118DNA-dependent DNA replication (GO:0006261)3.18929888
119regulation of ligase activity (GO:0051340)3.17940069
120polyamine biosynthetic process (GO:0006596)3.17251151
121regulation of G0 to G1 transition (GO:0070316)3.13089004
122regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11221378
123motile cilium assembly (GO:0044458)3.10478791
124DNA methylation involved in gamete generation (GO:0043046)3.10326777
125protein localization to kinetochore (GO:0034501)3.08598777
126negative regulation of chromosome segregation (GO:0051985)3.06892052
127negative regulation of sister chromatid segregation (GO:0033046)3.06497534
128negative regulation of mitotic sister chromatid separation (GO:2000816)3.06497534
129negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06497534
130negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06497534
131chromosome organization involved in meiosis (GO:0070192)3.05665838
132mitotic spindle checkpoint (GO:0071174)3.05642731
133DNA packaging (GO:0006323)3.05244403
134meiotic nuclear division (GO:0007126)3.04731287
135interferon-gamma secretion (GO:0072643)3.04684572
136regulation of mitotic spindle organization (GO:0060236)3.02407035
137axoneme assembly (GO:0035082)3.02328451
138neuronal action potential (GO:0019228)3.01508759
139CENP-A containing nucleosome assembly (GO:0034080)3.01174762
140signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00926310
141mitochondrial respiratory chain complex I assembly (GO:0032981)2.96478612
142NADH dehydrogenase complex assembly (GO:0010257)2.96478612
143mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96478612
144RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95783233
145tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95783233
146nonmotile primary cilium assembly (GO:0035058)2.95248558
147centriole assembly (GO:0098534)2.92938560
148gamete generation (GO:0007276)2.92210876
149protein localization to Golgi apparatus (GO:0034067)2.88471594
150regulation of action potential (GO:0098900)2.83460731
151G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.82042157
152single fertilization (GO:0007338)2.82001671
153chromosome condensation (GO:0030261)2.81427201
154mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.80435190
155retrograde transport, vesicle recycling within Golgi (GO:0000301)2.78702734
156synaptic transmission, cholinergic (GO:0007271)2.76537585
157negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.76457304
158negative regulation of telomere maintenance (GO:0032205)2.75545650
159protein complex biogenesis (GO:0070271)2.71005510
160negative regulation of inclusion body assembly (GO:0090084)2.70333862
161primary amino compound metabolic process (GO:1901160)2.67557547
162microtubule severing (GO:0051013)2.67117099
163neuromuscular synaptic transmission (GO:0007274)2.62409206
164cilium organization (GO:0044782)2.61454227
165mannosylation (GO:0097502)2.61418639
166seminiferous tubule development (GO:0072520)2.61081844
167NAD biosynthetic process (GO:0009435)2.59343516
168hydrogen ion transmembrane transport (GO:1902600)2.58922183
169sulfation (GO:0051923)2.58063157
170arginine catabolic process (GO:0006527)2.53726345
171cilium assembly (GO:0042384)2.53548693
172phosphatidylethanolamine metabolic process (GO:0046337)2.52430321
173kynurenine metabolic process (GO:0070189)2.52329051
174membrane depolarization during action potential (GO:0086010)2.51994012
175fucose catabolic process (GO:0019317)2.50209584
176L-fucose metabolic process (GO:0042354)2.50209584
177L-fucose catabolic process (GO:0042355)2.50209584
178proton transport (GO:0015992)2.49910674
179phosphatidylethanolamine biosynthetic process (GO:0006646)2.49897026
180regulation of rhodopsin mediated signaling pathway (GO:0022400)2.49413713
181indole-containing compound catabolic process (GO:0042436)2.49335390
182indolalkylamine catabolic process (GO:0046218)2.49335390
183tryptophan catabolic process (GO:0006569)2.49335390
184peptidyl-threonine dephosphorylation (GO:0035970)2.47854039

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.94186396
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.80767165
3E2F7_22180533_ChIP-Seq_HELA_Human4.39303560
4EZH2_22144423_ChIP-Seq_EOC_Human4.05111667
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.79548608
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.78556432
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.74527168
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.65095505
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.63130822
10ZNF274_21170338_ChIP-Seq_K562_Hela3.57992037
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.42734889
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.38217249
13FOXM1_23109430_ChIP-Seq_U2OS_Human3.25472916
14EST1_17652178_ChIP-ChIP_JURKAT_Human3.17789006
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97550677
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89627687
17VDR_22108803_ChIP-Seq_LS180_Human2.78380249
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68163028
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.66832365
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63269140
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.51633569
22VDR_23849224_ChIP-Seq_CD4+_Human2.44920582
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43893137
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35782360
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26470644
26AR_21909140_ChIP-Seq_LNCAP_Human2.23613944
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22941276
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21290366
29GABP_19822575_ChIP-Seq_HepG2_Human2.11032664
30ZNF263_19887448_ChIP-Seq_K562_Human2.07450318
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07038241
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06041829
33GBX2_23144817_ChIP-Seq_PC3_Human2.03910446
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.98999417
35* XRN2_22483619_ChIP-Seq_HELA_Human1.97786645
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96702945
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.95977858
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.92040019
39FUS_26573619_Chip-Seq_HEK293_Human1.90562869
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87692641
41DCP1A_22483619_ChIP-Seq_HELA_Human1.85140116
42REST_21632747_ChIP-Seq_MESCs_Mouse1.83372463
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83327075
44* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81997903
45FOXP3_21729870_ChIP-Seq_TREG_Human1.80726585
46TAF15_26573619_Chip-Seq_HEK293_Human1.79197689
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77907651
48ER_23166858_ChIP-Seq_MCF-7_Human1.74660038
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.71367147
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69310801
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68349598
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.67918604
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66993142
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63524226
55CBP_20019798_ChIP-Seq_JUKART_Human1.63524226
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63416498
57* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.61944466
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60100134
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.59610375
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58988086
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58956364
62P300_19829295_ChIP-Seq_ESCs_Human1.58086773
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57426572
64TTF2_22483619_ChIP-Seq_HELA_Human1.56548376
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55728527
66KDM5A_27292631_Chip-Seq_BREAST_Human1.55352742
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54486738
68KAP1_22055183_ChIP-Seq_ESCs_Mouse1.52880505
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51799947
70IRF1_19129219_ChIP-ChIP_H3396_Human1.50663017
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48984584
72TAF2_19829295_ChIP-Seq_ESCs_Human1.47072033
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46249665
74* NANOG_20526341_ChIP-Seq_ESCs_Human1.45857679
75* ERA_21632823_ChIP-Seq_H3396_Human1.45020197
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42375337
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42375337
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.39921678
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.39398584
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38064162
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37995350
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37800152
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.37638916
84AR_25329375_ChIP-Seq_VCAP_Human1.36884217
85* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36803937
86AR_21572438_ChIP-Seq_LNCaP_Human1.35507735
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34789044
88MYC_19829295_ChIP-Seq_ESCs_Human1.34224206
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33700371
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.33700371
91* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.32623095
92NCOR_22424771_ChIP-Seq_293T_Human1.32583435
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.32404008
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32367011
95REST_18959480_ChIP-ChIP_MESCs_Mouse1.31892053
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29771798
97EED_16625203_ChIP-ChIP_MESCs_Mouse1.29715578
98DROSHA_22980978_ChIP-Seq_HELA_Human1.29566509
99WDR5_24793694_ChIP-Seq_LNCAP_Human1.29429368
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29351559
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27247937
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26921035
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26623032
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.25979091
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25895980
106HOXB7_26014856_ChIP-Seq_BT474_Human1.25352366
107RAC3_21632823_ChIP-Seq_H3396_Human1.24703247
108* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24157755
109POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24088343
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23839827
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22786960
112E2F1_21310950_ChIP-Seq_MCF-7_Human1.22665434
113RNF2_27304074_Chip-Seq_NSC_Mouse1.22625061
114OCT4_20526341_ChIP-Seq_ESCs_Human1.22593681
115TDRD3_21172665_ChIP-Seq_MCF-7_Human1.22585421
116TP53_22573176_ChIP-Seq_HFKS_Human1.20854318
117ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19533991
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18972493
119* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18673064
120RUNX2_22187159_ChIP-Seq_PCA_Human1.18145589
121STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17196683
122JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17142848
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17112322
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16260820
125ELK1_19687146_ChIP-ChIP_HELA_Human1.14958437
126NANOG_19829295_ChIP-Seq_ESCs_Human1.14628891
127SOX2_19829295_ChIP-Seq_ESCs_Human1.14628891
128PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12981799
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12692955
130SMAD3_21741376_ChIP-Seq_EPCs_Human1.12396525
131TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12357241
132* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12162481
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11835707
134SMAD4_21741376_ChIP-Seq_EPCs_Human1.11423023
135ELK1_22589737_ChIP-Seq_MCF10A_Human1.11312653
136STAT3_23295773_ChIP-Seq_U87_Human1.10688050
137DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10203977
138ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09498600
139MYC_18940864_ChIP-ChIP_HL60_Human1.09319441
140EWS_26573619_Chip-Seq_HEK293_Human1.09250384
141NOTCH1_21737748_ChIP-Seq_TLL_Human1.09078596
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07919699
143CTCF_20526341_ChIP-Seq_ESCs_Human1.07740319
144P53_21459846_ChIP-Seq_SAOS-2_Human1.07725753
145CIITA_25753668_ChIP-Seq_RAJI_Human1.07107249
146FOXH1_21741376_ChIP-Seq_EPCs_Human1.06963760
147JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05195581
148GATA1_26923725_Chip-Seq_HPCs_Mouse1.04594868
149TCF4_23295773_ChIP-Seq_U87_Human1.03612346
150SMAD4_21799915_ChIP-Seq_A2780_Human1.03308898
151ERG_20517297_ChIP-Seq_VCAP_Human1.02941484
152SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02701627
153ETV1_20927104_ChIP-Seq_GIST48_Human1.02649686
154E2F1_20622854_ChIP-Seq_HELA_Human1.02135930
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00473069
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.99066517
157FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97581173
158SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97559056
159* BCL6_27268052_Chip-Seq_Bcells_Human0.96740713
160POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96533579
161SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96524866
162YY1_22570637_ChIP-Seq_MALME-3M_Human0.96482064
163NANOG_21062744_ChIP-ChIP_HESCs_Human0.95308802
164P300_27268052_Chip-Seq_Bcells_Human0.95261123
165TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95023571
166AR_20517297_ChIP-Seq_VCAP_Human0.94816955
167PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94320534
168BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93222251
169SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91707347
170NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89723795
171* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.86472964
172E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86390326
173SALL1_21062744_ChIP-ChIP_HESCs_Human0.85670723
174CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83830999
175TP63_19390658_ChIP-ChIP_HaCaT_Human0.83037353
176CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81686944
177* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81635277
178SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80249234
179GATA3_21867929_ChIP-Seq_CD8_Mouse0.80116325
180HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78838207
181FOXP1_21924763_ChIP-Seq_HESCs_Human0.75190792
182CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75125162
183TET1_21451524_ChIP-Seq_MESCs_Mouse0.73892023
184NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73253090
185FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72588966
186NANOG_18692474_ChIP-Seq_MEFs_Mouse0.72146591
187KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.71937385
188* KAP1_27257070_Chip-Seq_ESCs_Mouse0.71772855
189* RARA_24833708_ChIP-Seq_LIVER_Mouse0.71690967
190CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71488346
191FLI1_21867929_ChIP-Seq_CD8_Mouse0.71392929
192CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.69810903

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.56450310
2MP0003111_abnormal_nucleus_morphology4.92272680
3MP0005410_abnormal_fertilization4.76937349
4MP0003718_maternal_effect4.27740751
5MP0004957_abnormal_blastocyst_morpholog4.08137458
6MP0010094_abnormal_chromosome_stability3.69767202
7MP0008260_abnormal_autophagy3.55065394
8MP0003077_abnormal_cell_cycle3.40502858
9MP0008058_abnormal_DNA_repair3.22238090
10MP0008877_abnormal_DNA_methylation3.07458531
11MP0001929_abnormal_gametogenesis2.84523141
12MP0003786_premature_aging2.79122391
13MP0008057_abnormal_DNA_replication2.78145020
14MP0003698_abnormal_male_reproductive2.52634042
15MP0002210_abnormal_sex_determination2.38745817
16MP0001968_abnormal_touch/_nociception2.37054007
17MP0008932_abnormal_embryonic_tissue2.29958469
18MP0001730_embryonic_growth_arrest2.26791326
19MP0005551_abnormal_eye_electrophysiolog2.17863595
20MP0005423_abnormal_somatic_nervous2.17685753
21MP0008007_abnormal_cellular_replicative2.16256732
22MP0005451_abnormal_body_composition2.14238374
23MP0003880_abnormal_central_pattern2.13009672
24MP0004885_abnormal_endolymph2.12575570
25MP0001145_abnormal_male_reproductive2.11693094
26MP0003123_paternal_imprinting2.11195756
27MP0001485_abnormal_pinna_reflex2.06241539
28MP0002735_abnormal_chemical_nociception2.05087779
29MP0004742_abnormal_vestibular_system2.04754155
30MP0005646_abnormal_pituitary_gland2.02219971
31MP0009745_abnormal_behavioral_response1.99784183
32MP0001486_abnormal_startle_reflex1.97009356
33MP0002272_abnormal_nervous_system1.92675904
34MP0001661_extended_life_span1.92118558
35MP0009840_abnormal_foam_cell1.91078663
36MP0000653_abnormal_sex_gland1.87763805
37MP0005645_abnormal_hypothalamus_physiol1.86760076
38MP0002653_abnormal_ependyma_morphology1.86561799
39MP0003011_delayed_dark_adaptation1.85315660
40MP0006292_abnormal_olfactory_placode1.84578719
41MP0000569_abnormal_digit_pigmentation1.79591836
42MP0002822_catalepsy1.74193497
43MP0004147_increased_porphyrin_level1.71042159
44MP0006072_abnormal_retinal_apoptosis1.71036064
45MP0004133_heterotaxia1.70958988
46MP0001672_abnormal_embryogenesis/_devel1.70179861
47MP0005380_embryogenesis_phenotype1.70179861
48MP0002161_abnormal_fertility/fecundity1.69589792
49MP0002736_abnormal_nociception_after1.65758434
50MP0003878_abnormal_ear_physiology1.65596083
51MP0005377_hearing/vestibular/ear_phenot1.65596083
52MP0005395_other_phenotype1.61603080
53MP0001529_abnormal_vocalization1.60382860
54MP0002733_abnormal_thermal_nociception1.58121461
55MP0002572_abnormal_emotion/affect_behav1.55939494
56MP0003635_abnormal_synaptic_transmissio1.55364826
57MP0001970_abnormal_pain_threshold1.54873036
58MP0000350_abnormal_cell_proliferation1.53753589
59MP0004142_abnormal_muscle_tone1.52554419
60MP0000566_synostosis1.51229253
61MP0010307_abnormal_tumor_latency1.47915256
62MP0003984_embryonic_growth_retardation1.45778280
63MP0002557_abnormal_social/conspecific_i1.45700044
64MP0006276_abnormal_autonomic_nervous1.45058900
65MP0002064_seizures1.42344664
66MP0002088_abnormal_embryonic_growth/wei1.42030043
67MP0001697_abnormal_embryo_size1.40754887
68MP0003646_muscle_fatigue1.40067560
69MP0002080_prenatal_lethality1.39801857
70MP0005084_abnormal_gallbladder_morpholo1.39795564
71MP0008872_abnormal_physiological_respon1.39614437
72MP0004145_abnormal_muscle_electrophysio1.39184519
73MP0005253_abnormal_eye_physiology1.38095615
74MP0004859_abnormal_synaptic_plasticity1.37935876
75MP0001984_abnormal_olfaction1.36976622
76MP0008789_abnormal_olfactory_epithelium1.36763365
77MP0005670_abnormal_white_adipose1.35354153
78MP0003787_abnormal_imprinting1.34395196
79MP0002067_abnormal_sensory_capabilities1.34006759
80MP0000026_abnormal_inner_ear1.33497592
81MP0002734_abnormal_mechanical_nocicepti1.31807498
82MP0001542_abnormal_bone_strength1.30862357
83MP0002160_abnormal_reproductive_system1.25778742
84MP0003938_abnormal_ear_development1.25397831
85MP0008875_abnormal_xenobiotic_pharmacok1.25122483
86MP0003221_abnormal_cardiomyocyte_apopto1.24408422
87MP0001905_abnormal_dopamine_level1.23676207
88MP0003567_abnormal_fetal_cardiomyocyte1.22121518
89MP0000049_abnormal_middle_ear1.21267915
90MP0002837_dystrophic_cardiac_calcinosis1.20647162
91MP0002063_abnormal_learning/memory/cond1.20521146
92MP0001963_abnormal_hearing_physiology1.19313920
93MP0005499_abnormal_olfactory_system1.18627877
94MP0005394_taste/olfaction_phenotype1.18627877
95MP0009333_abnormal_splenocyte_physiolog1.18207292
96MP0005389_reproductive_system_phenotype1.17927047
97MP0004019_abnormal_vitamin_homeostasis1.17815111
98MP0005167_abnormal_blood-brain_barrier1.17009610
99MP0003315_abnormal_perineum_morphology1.16029963
100MP0002085_abnormal_embryonic_tissue1.15722291
101MP0000955_abnormal_spinal_cord1.15568718
102MP0000631_abnormal_neuroendocrine_gland1.15468260
103MP0002234_abnormal_pharynx_morphology1.15201466
104MP0005379_endocrine/exocrine_gland_phen1.13490464
105MP0001501_abnormal_sleep_pattern1.12858837
106MP0010386_abnormal_urinary_bladder1.12547612
107MP0002229_neurodegeneration1.12339944
108MP0004084_abnormal_cardiac_muscle1.10944646
109MP0000750_abnormal_muscle_regeneration1.10835448
110MP0001440_abnormal_grooming_behavior1.10261599
111MP0006035_abnormal_mitochondrial_morpho1.09052391
112MP0003122_maternal_imprinting1.07759953
113MP0002638_abnormal_pupillary_reflex1.07590640
114MP0000358_abnormal_cell_content/1.05983043
115MP0009672_abnormal_birth_weight1.04401374
116MP0000313_abnormal_cell_death1.03275904
117MP0002876_abnormal_thyroid_physiology1.02871147
118MP0004043_abnormal_pH_regulation1.02157422
119MP0006036_abnormal_mitochondrial_physio1.00449762
120MP0003136_yellow_coat_color0.99572075
121MP0005397_hematopoietic_system_phenotyp0.98138701
122MP0001545_abnormal_hematopoietic_system0.98138701
123MP0002132_abnormal_respiratory_system0.97426446
124MP0002396_abnormal_hematopoietic_system0.96533509
125MP0004924_abnormal_behavior0.96098486
126MP0005386_behavior/neurological_phenoty0.96098486
127MP0002102_abnormal_ear_morphology0.95896734
128MP0002752_abnormal_somatic_nervous0.94288190
129MP0002086_abnormal_extraembryonic_tissu0.93980871
130MP0003699_abnormal_female_reproductive0.93948750
131MP0005174_abnormal_tail_pigmentation0.93744092
132MP0000778_abnormal_nervous_system0.92017119
133MP0003121_genomic_imprinting0.91855163
134MP0002163_abnormal_gland_morphology0.91439257
135MP0002938_white_spotting0.91036094
136MP0002084_abnormal_developmental_patter0.90981867
137MP0003195_calcinosis0.89824170
138MP0002184_abnormal_innervation0.86806025
139MP0001765_abnormal_ion_homeostasis0.86108043
140MP0001764_abnormal_homeostasis0.85923381
141MP0005195_abnormal_posterior_eye0.85230427
142MP0002882_abnormal_neuron_morphology0.83198120
143MP0003283_abnormal_digestive_organ0.82111643
144MP0001188_hyperpigmentation0.81365276
145MP0001119_abnormal_female_reproductive0.80451696
146MP0008961_abnormal_basal_metabolism0.80055794
147MP0005636_abnormal_mineral_homeostasis0.78801099
148MP0001727_abnormal_embryo_implantation0.77190321
149MP0003879_abnormal_hair_cell0.76777170
150MP0005621_abnormal_cell_physiology0.73936295
151MP0001293_anophthalmia0.73741822
152MP0005384_cellular_phenotype0.73049285
153MP0002019_abnormal_tumor_incidence0.71306046
154MP0008995_early_reproductive_senescence0.71029606
155MP0005332_abnormal_amino_acid0.69102023
156MP0001919_abnormal_reproductive_system0.68185771
157MP0000747_muscle_weakness0.65149920
158MP0009703_decreased_birth_body0.64975356
159MP0002127_abnormal_cardiovascular_syste0.62742041
160MP0002269_muscular_atrophy0.62362816
161MP0000647_abnormal_sebaceous_gland0.62026692
162MP0001756_abnormal_urination0.61232964
163MP0001986_abnormal_taste_sensitivity0.60242940
164MP0000627_abnormal_mammary_gland0.59732291
165MP0004197_abnormal_fetal_growth/weight/0.59324472
166MP0003941_abnormal_skin_development0.58862316
167MP0003937_abnormal_limbs/digits/tail_de0.55631724
168MP0003119_abnormal_digestive_system0.55608559
169MP0003936_abnormal_reproductive_system0.54653825
170MP0002092_abnormal_eye_morphology0.54344495
171MP0000490_abnormal_crypts_of0.53723611
172MP0000428_abnormal_craniofacial_morphol0.53196018
173MP0003186_abnormal_redox_activity0.51513789
174MP0002169_no_abnormal_phenotype0.47550879
175MP0005257_abnormal_intraocular_pressure0.47230863
176MP0002873_normal_phenotype0.46792916
177MP0004808_abnormal_hematopoietic_stem0.43355316
178MP0000001_mammalian_phenotype0.42863731
179MP0009046_muscle_twitch0.38645119

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)5.49592915
2Birth length less than 3rd percentile (HP:0003561)5.45970111
3Impulsivity (HP:0100710)5.08942142
4Hyperglycinemia (HP:0002154)4.94573365
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.82397910
6Cerebral hypomyelination (HP:0006808)4.72421652
7Type II lissencephaly (HP:0007260)4.49750522
8Carpal bone hypoplasia (HP:0001498)4.31974342
9Rough bone trabeculation (HP:0100670)4.13611071
10Hyperglycinuria (HP:0003108)3.98498377
11Abnormal spermatogenesis (HP:0008669)3.80548205
12Ureteral duplication (HP:0000073)3.78928040
13Cerebellar dysplasia (HP:0007033)3.76876556
14Attenuation of retinal blood vessels (HP:0007843)3.64204738
15Molar tooth sign on MRI (HP:0002419)3.61404177
16Abnormality of midbrain morphology (HP:0002418)3.61404177
17Severe visual impairment (HP:0001141)3.61077628
18Nephronophthisis (HP:0000090)3.59054829
19Progressive muscle weakness (HP:0003323)3.57828360
20Dynein arm defect of respiratory motile cilia (HP:0012255)3.55397661
21Absent/shortened dynein arms (HP:0200106)3.55397661
22Chronic hepatic failure (HP:0100626)3.51178243
23True hermaphroditism (HP:0010459)3.48985690
24Bundle branch block (HP:0011710)3.42984383
25Abnormal respiratory motile cilium morphology (HP:0005938)3.41682066
26Abnormal respiratory epithelium morphology (HP:0012253)3.41682066
27Abnormality of the umbilical cord (HP:0010881)3.40779530
28Male infertility (HP:0003251)3.32927961
29Congenital stationary night blindness (HP:0007642)3.29455645
30Abnormality of glycine metabolism (HP:0010895)3.28174955
31Abnormality of serine family amino acid metabolism (HP:0010894)3.28174955
32Aplasia/Hypoplasia of the patella (HP:0006498)3.25112193
33Secondary amenorrhea (HP:0000869)3.23077025
34Gout (HP:0001997)3.22378906
35Patellar aplasia (HP:0006443)3.18057665
36Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.14268763
37Abnormal rod and cone electroretinograms (HP:0008323)3.12672076
38Premature ovarian failure (HP:0008209)3.11330168
39CNS hypomyelination (HP:0003429)3.11116908
40Bony spicule pigmentary retinopathy (HP:0007737)3.08342572
41Abnormality of the renal medulla (HP:0100957)3.04683404
42Abnormal trabecular bone morphology (HP:0100671)3.01399130
43Progressive cerebellar ataxia (HP:0002073)2.98734246
44Entropion (HP:0000621)2.98430922
45Chronic bronchitis (HP:0004469)2.97348712
46Abnormal respiratory motile cilium physiology (HP:0012261)2.92038597
47Infertility (HP:0000789)2.89156961
48Multiple enchondromatosis (HP:0005701)2.88789080
49Delusions (HP:0000746)2.84931491
50Acute necrotizing encephalopathy (HP:0006965)2.84334390
51Acute encephalopathy (HP:0006846)2.80639429
52Pendular nystagmus (HP:0012043)2.79886216
53Abnormal drinking behavior (HP:0030082)2.79443787
54Polydipsia (HP:0001959)2.79443787
55Atrioventricular block (HP:0001678)2.79035593
56Death in infancy (HP:0001522)2.78868430
57Rhinitis (HP:0012384)2.78343687
58Ventricular fibrillation (HP:0001663)2.77230301
59Azoospermia (HP:0000027)2.74151715
60Abnormality of serum amino acid levels (HP:0003112)2.73041735
61Degeneration of anterior horn cells (HP:0002398)2.72704567
62Abnormality of the anterior horn cell (HP:0006802)2.72704567
63Medial flaring of the eyebrow (HP:0010747)2.70970291
64Pancreatic fibrosis (HP:0100732)2.66334576
65Renal Fanconi syndrome (HP:0001994)2.65843753
66Personality changes (HP:0000751)2.64951201
67Lissencephaly (HP:0001339)2.62503961
68Muscle fiber splitting (HP:0003555)2.57139846
69Tetraplegia (HP:0002445)2.56912030
70Areflexia of lower limbs (HP:0002522)2.56049661
71Glucose intolerance (HP:0000833)2.55904286
72Optic disc pallor (HP:0000543)2.55513478
73Abnormality of the renal cortex (HP:0011035)2.55184233
74Absent radius (HP:0003974)2.54539214
75Tubular atrophy (HP:0000092)2.52743452
76Megaloblastic anemia (HP:0001889)2.50615681
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.50292033
78Sclerocornea (HP:0000647)2.50122262
79Polyuria (HP:0000103)2.48436352
80Retinal dysplasia (HP:0007973)2.46196954
81Microretrognathia (HP:0000308)2.40907887
82Abnormality of cells of the erythroid lineage (HP:0012130)2.40905559
83Mitochondrial inheritance (HP:0001427)2.40243862
84Abnormal mitochondria in muscle tissue (HP:0008316)2.40216431
85Anterior segment dysgenesis (HP:0007700)2.38556403
86Absent forearm bone (HP:0003953)2.37665065
87Aplasia involving forearm bones (HP:0009822)2.37665065
88Short nail (HP:0001799)2.33912969
89Gait imbalance (HP:0002141)2.33570653
90Increased hepatocellular lipid droplets (HP:0006565)2.31845150
91Abnormality of alanine metabolism (HP:0010916)2.30526219
92Hyperalaninemia (HP:0003348)2.30526219
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30526219
94Abnormal urine output (HP:0012590)2.29528332
95Aplasia/Hypoplasia involving the musculature (HP:0001460)2.29195758
963-Methylglutaconic aciduria (HP:0003535)2.28626096
97Abnormal number of erythroid precursors (HP:0012131)2.28198464
98Increased CSF lactate (HP:0002490)2.28193555
99Progressive macrocephaly (HP:0004481)2.27589633
100Difficulty climbing stairs (HP:0003551)2.25723626
101Cystic liver disease (HP:0006706)2.25197095
102Increased corneal curvature (HP:0100692)2.22273713
103Keratoconus (HP:0000563)2.22273713
104Sparse eyelashes (HP:0000653)2.22241223
105Double outlet right ventricle (HP:0001719)2.21051011
106Congenital malformation of the right heart (HP:0011723)2.21051011
107Lipid accumulation in hepatocytes (HP:0006561)2.20220934
108Cleft eyelid (HP:0000625)2.19792257
109Patent foramen ovale (HP:0001655)2.19184114
110Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17355086
111Myokymia (HP:0002411)2.15737037
112Oral leukoplakia (HP:0002745)2.15204092
113Occipital encephalocele (HP:0002085)2.14106710
114Optic nerve hypoplasia (HP:0000609)2.13341197
115Congenital primary aphakia (HP:0007707)2.12799701
116Bilateral microphthalmos (HP:0007633)2.12519152
117Anencephaly (HP:0002323)2.12491051
118Abnormalities of placenta or umbilical cord (HP:0001194)2.10755009
119Testicular atrophy (HP:0000029)2.08348067
120Meckel diverticulum (HP:0002245)2.07263360
121Trismus (HP:0000211)2.07186152
122Pancreatic cysts (HP:0001737)2.06055934
123Severe muscular hypotonia (HP:0006829)2.05714769
124Postnatal microcephaly (HP:0005484)2.04279672
125Abnormal ciliary motility (HP:0012262)2.04090042
126Facial cleft (HP:0002006)2.02207948
127Heart block (HP:0012722)2.01856044
128Aplasia/Hypoplasia of the earlobes (HP:0009906)2.01621595
129Macrocytic anemia (HP:0001972)2.01364705
130Oligodactyly (hands) (HP:0001180)2.01299407
131Brittle hair (HP:0002299)2.01130500
132Abnormality of the preputium (HP:0100587)2.01122227
133Progressive external ophthalmoplegia (HP:0000590)2.00554665
134Absent hand (HP:0004050)1.99685997
135Abnormality of renal excretion (HP:0011036)1.99591677
136Gaze-evoked nystagmus (HP:0000640)1.99577512
137Breast aplasia (HP:0100783)1.98720973
138Tongue fasciculations (HP:0001308)1.98267722
139Congenital, generalized hypertrichosis (HP:0004540)1.97660402
140Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96248205
141Oligodactyly (HP:0012165)1.95653514
142Horseshoe kidney (HP:0000085)1.95488349
143Abnormality of urine glucose concentration (HP:0011016)1.94902968
144Glycosuria (HP:0003076)1.94902968
145Decreased central vision (HP:0007663)1.94694768
146Concave nail (HP:0001598)1.94689310
147Unsteady gait (HP:0002317)1.93743309
148Nephrogenic diabetes insipidus (HP:0009806)1.93540697
149Muscle fibrillation (HP:0010546)1.92891306
150Absent epiphyses (HP:0010577)1.92829906
151Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92829906
152Abnormality of macular pigmentation (HP:0008002)1.92781411
153Abnormality of the distal phalanges of the toes (HP:0010182)1.91946991
154Male pseudohermaphroditism (HP:0000037)1.91911266
155Irregular epiphyses (HP:0010582)1.91909864
156Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91587322
157Hypoplasia of the brainstem (HP:0002365)1.91587322
158Inability to walk (HP:0002540)1.91317687
159Congenital hepatic fibrosis (HP:0002612)1.89608016
160Limb dystonia (HP:0002451)1.89347812
161Premature rupture of membranes (HP:0001788)1.89039170
162Abnormality of the ileum (HP:0001549)1.88670969
163Prolonged neonatal jaundice (HP:0006579)1.88505527
164Aplasia/Hypoplasia of the breasts (HP:0010311)1.88111882
165Decreased circulating renin level (HP:0003351)1.84856219
166Abnormality of renal resorption (HP:0011038)1.83771803
167Hypoplasia of the uterus (HP:0000013)1.80846734
168Aplasia/hypoplasia of the uterus (HP:0008684)1.80758729
169Tubulointerstitial nephritis (HP:0001970)1.80132556
170Genital tract atresia (HP:0001827)1.78426145
171Vaginal atresia (HP:0000148)1.77479090
172Generalized aminoaciduria (HP:0002909)1.76571666
173Pachygyria (HP:0001302)1.76455844
174Genetic anticipation (HP:0003743)1.74147480
175Constricted visual fields (HP:0001133)1.73766894
176Abolished electroretinogram (ERG) (HP:0000550)1.73528432
177Febrile seizures (HP:0002373)1.72630455
178Atonic seizures (HP:0010819)1.72387190
179Abnormality of the aortic arch (HP:0012303)1.69201302
180Stage 5 chronic kidney disease (HP:0003774)1.68214909
181Facial shape deformation (HP:0011334)1.67417705
182Potter facies (HP:0002009)1.67417705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.01380955
2WEE14.65100302
3PLK43.59555618
4MAP4K23.59309632
5PDK33.37071584
6PDK43.37071584
7ADRBK23.10935428
8WNK42.99957874
9PNCK2.99218402
10STK162.91620720
11NEK22.84665906
12BRSK22.69398303
13INSRR2.68444694
14AKT32.62293734
15TAOK32.53219305
16EIF2AK12.45581640
17TTK2.33300390
18DYRK32.31609704
19PDK22.27922499
20SRPK12.18599676
21BMPR1B2.18142201
22GRK12.08147765
23NME22.02941801
24CASK1.91773207
25CCNB11.90613144
26FRK1.89667759
27PLK11.85443791
28TSSK61.83652557
29IRAK31.81563831
30BRSK11.80968366
31MAPK151.80224088
32PLK21.72250547
33PLK31.71740542
34ARAF1.55515010
35MKNK21.54546343
36EPHA21.54063725
37ZAK1.54017149
38TXK1.52822333
39STK38L1.48719369
40EIF2AK31.44910290
41MAPK131.44542596
42SIK21.44229150
43NEK11.40909955
44CHEK21.39899108
45BRAF1.34863121
46DAPK21.29219841
47ACVR1B1.27276605
48TNK21.24747979
49CDC71.23726122
50TNIK1.23572758
51DYRK1B1.23481734
52PAK31.21436734
53WNK11.21364353
54AURKB1.21183498
55TESK21.20004529
56TIE11.17414830
57MAP2K71.16610013
58RPS6KA41.15730799
59PINK11.12583563
60NME11.12322945
61MKNK11.10600368
62MAP3K41.10478139
63NTRK21.09149705
64AURKA1.08406533
65TRIM281.06499926
66NTRK31.03746266
67STK30.99922392
68OXSR10.94985453
69CDK40.94167126
70PHKG20.92387371
71PHKG10.92387371
72LATS20.91898470
73STK380.89448529
74TESK10.88934425
75CHEK10.85679570
76DYRK20.83647023
77ADRBK10.83269388
78DDR20.82650970
79CAMKK20.79691310
80PRKCI0.79214172
81CAMK10.79177977
82PIM20.78141759
83PAK10.77346564
84MAPKAPK50.76148035
85MARK10.75679822
86ATR0.74381329
87MARK30.72810984
88PRKCE0.71292951
89MAP3K80.69106390
90GRK70.68140750
91ALK0.67639235
92UHMK10.63444170
93LIMK10.62192745
94PRKCQ0.62146208
95VRK10.60234721
96IRAK20.58682684
97TYRO30.57747354
98PRKD30.57553016
99CDK20.57185509
100PRKACA0.56884695
101MINK10.56793455
102VRK20.56614477
103CSNK2A20.54775155
104PRKG10.54051291
105PTK2B0.53716411
106CSNK2A10.53713345
107CAMK2A0.53654292
108CDK70.53119344
109ABL20.53100465
110CAMK1G0.52521313
111NUAK10.51582742
112MAP3K110.49445199
113EPHA40.49416409
114STK110.48627309
115CSNK1E0.48547101
116KIT0.48412488
117PAK40.48392061
118PKN10.48254737
119PIK3CA0.47787610
120SGK4940.45789148
121SGK2230.45789148
122CAMKK10.45474604
123IKBKB0.45023535
124CDK30.44917333
125EIF2AK20.44449957
126CAMK40.43556280
127PIM10.43087851
128MAP3K90.42418983
129PRKCA0.41955756
130PRKACB0.41812679
131CDK10.41386170
132MUSK0.41010736
133RPS6KA50.40965198
134MELK0.40672002
135ATM0.40437167
136CHUK0.40327871
137PRKCG0.39917336
138DYRK1A0.39775290
139CSNK1G10.36990281
140TGFBR10.36574785
141RPS6KA60.35864319
142PRKCZ0.34881927
143CSNK1G30.33658679
144STK240.33529878
145SGK10.33015548
146PRKCH0.32423164
147CSNK1D0.32258611
148SGK20.32120763
149STK40.31056835
150MAP3K50.28273420
151TAOK10.26017849
152MAP2K20.25243442
153BCKDK0.25166310
154PRKAA10.25025623
155CSNK1A10.21700606
156STK390.19255334
157WNK30.18912521
158MTOR0.18864859
159MAP3K30.18696476
160KDR0.17491654
161RAF10.17227825
162IRAK10.17136941
163PDK10.16877594
164CAMK2G0.15714912
165MAPK100.14819719
166CSNK1G20.14681387
167TLK10.13744041
168ICK0.13102585
169CDK60.12348889
170SCYL20.12107414

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.61294080
2RNA polymerase_Homo sapiens_hsa030204.87312503
3Proteasome_Homo sapiens_hsa030504.51883081
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.46081620
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.63996690
6RNA transport_Homo sapiens_hsa030133.46868150
7Oxidative phosphorylation_Homo sapiens_hsa001903.30538605
8Pyrimidine metabolism_Homo sapiens_hsa002402.83390086
9Nicotine addiction_Homo sapiens_hsa050332.70373949
10Parkinsons disease_Homo sapiens_hsa050122.67692244
11DNA replication_Homo sapiens_hsa030302.67322628
12Basal transcription factors_Homo sapiens_hsa030222.66356447
13Spliceosome_Homo sapiens_hsa030402.51928953
14Olfactory transduction_Homo sapiens_hsa047402.28925814
15Cardiac muscle contraction_Homo sapiens_hsa042602.28779195
16Cell cycle_Homo sapiens_hsa041102.24902929
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.23681071
18Ribosome_Homo sapiens_hsa030102.23094988
19Regulation of autophagy_Homo sapiens_hsa041402.18090437
20Mismatch repair_Homo sapiens_hsa034302.02630077
21Purine metabolism_Homo sapiens_hsa002301.98979749
22Folate biosynthesis_Homo sapiens_hsa007901.97640719
23Taste transduction_Homo sapiens_hsa047421.94470477
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93230049
25Homologous recombination_Homo sapiens_hsa034401.91967015
26Nucleotide excision repair_Homo sapiens_hsa034201.91311927
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.90422929
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.88213291
29Pentose phosphate pathway_Homo sapiens_hsa000301.82824927
30Fanconi anemia pathway_Homo sapiens_hsa034601.78276793
31Alzheimers disease_Homo sapiens_hsa050101.77222760
32Base excision repair_Homo sapiens_hsa034101.76580834
33Morphine addiction_Homo sapiens_hsa050321.75755524
34Nitrogen metabolism_Homo sapiens_hsa009101.75004618
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.71005354
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.66694434
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56605287
38Oocyte meiosis_Homo sapiens_hsa041141.44898973
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43744899
40Caffeine metabolism_Homo sapiens_hsa002321.43734487
41GABAergic synapse_Homo sapiens_hsa047271.43280193
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41845730
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.39940066
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30832149
45mRNA surveillance pathway_Homo sapiens_hsa030151.30692889
46p53 signaling pathway_Homo sapiens_hsa041151.29557970
47Glutamatergic synapse_Homo sapiens_hsa047241.27180133
48Epstein-Barr virus infection_Homo sapiens_hsa051691.26765286
49RNA degradation_Homo sapiens_hsa030181.25324788
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.21465757
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20760607
52Fructose and mannose metabolism_Homo sapiens_hsa000511.20035697
53Circadian entrainment_Homo sapiens_hsa047131.19213148
54Vitamin digestion and absorption_Homo sapiens_hsa049771.16228469
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14861485
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13255531
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08387824
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08307241
59Tryptophan metabolism_Homo sapiens_hsa003801.07443398
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05641208
61Synaptic vesicle cycle_Homo sapiens_hsa047210.98770479
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97035336
63Insulin secretion_Homo sapiens_hsa049110.93120842
64Peroxisome_Homo sapiens_hsa041460.91831475
65Biosynthesis of amino acids_Homo sapiens_hsa012300.88607540
66Salivary secretion_Homo sapiens_hsa049700.86960803
67Serotonergic synapse_Homo sapiens_hsa047260.86000241
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84790997
69Type I diabetes mellitus_Homo sapiens_hsa049400.84485413
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82735625
71Linoleic acid metabolism_Homo sapiens_hsa005910.80534681
72ABC transporters_Homo sapiens_hsa020100.79825555
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.76937819
74Sulfur relay system_Homo sapiens_hsa041220.76889920
75Chemical carcinogenesis_Homo sapiens_hsa052040.76573428
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72561001
77Glutathione metabolism_Homo sapiens_hsa004800.72162879
78Calcium signaling pathway_Homo sapiens_hsa040200.70396855
79Carbon metabolism_Homo sapiens_hsa012000.67290564
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65955192
81Autoimmune thyroid disease_Homo sapiens_hsa053200.64788969
82Allograft rejection_Homo sapiens_hsa053300.64360689
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62940911
84One carbon pool by folate_Homo sapiens_hsa006700.60878821
85Primary immunodeficiency_Homo sapiens_hsa053400.60491666
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57693412
87Metabolic pathways_Homo sapiens_hsa011000.56567548
88Steroid biosynthesis_Homo sapiens_hsa001000.55145425
89Huntingtons disease_Homo sapiens_hsa050160.54802170
90Ovarian steroidogenesis_Homo sapiens_hsa049130.52747673
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52229085
92Selenocompound metabolism_Homo sapiens_hsa004500.51504312
93Asthma_Homo sapiens_hsa053100.51217716
94Non-homologous end-joining_Homo sapiens_hsa034500.50844092
95Dopaminergic synapse_Homo sapiens_hsa047280.50552288
96Graft-versus-host disease_Homo sapiens_hsa053320.48713372
97Cholinergic synapse_Homo sapiens_hsa047250.48413868
98Renin-angiotensin system_Homo sapiens_hsa046140.47262806
99Glycerolipid metabolism_Homo sapiens_hsa005610.46209012
100Arachidonic acid metabolism_Homo sapiens_hsa005900.46066206
101Tyrosine metabolism_Homo sapiens_hsa003500.45137182
102Phenylalanine metabolism_Homo sapiens_hsa003600.43938446
103Circadian rhythm_Homo sapiens_hsa047100.43663632
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42953811
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42685817
106Amphetamine addiction_Homo sapiens_hsa050310.41612738
107Arginine and proline metabolism_Homo sapiens_hsa003300.39434150
108cAMP signaling pathway_Homo sapiens_hsa040240.39096833
109Mineral absorption_Homo sapiens_hsa049780.38384921
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38156549
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35769154
112Antigen processing and presentation_Homo sapiens_hsa046120.35389948
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34627171
114Fatty acid degradation_Homo sapiens_hsa000710.34306335
115Cocaine addiction_Homo sapiens_hsa050300.34129376
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30900654
117Ether lipid metabolism_Homo sapiens_hsa005650.27582320
118Sphingolipid metabolism_Homo sapiens_hsa006000.27248655
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27053873
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26014165
121beta-Alanine metabolism_Homo sapiens_hsa004100.24991168
122Herpes simplex infection_Homo sapiens_hsa051680.23162022
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21274290
124Viral carcinogenesis_Homo sapiens_hsa052030.21211277
125Inositol phosphate metabolism_Homo sapiens_hsa005620.20032053
126Fat digestion and absorption_Homo sapiens_hsa049750.19854814
127mTOR signaling pathway_Homo sapiens_hsa041500.19795290
128Protein export_Homo sapiens_hsa030600.18508646
129Collecting duct acid secretion_Homo sapiens_hsa049660.15687833
130Galactose metabolism_Homo sapiens_hsa000520.15088238
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13024471
132FoxO signaling pathway_Homo sapiens_hsa040680.12276080
133Fatty acid biosynthesis_Homo sapiens_hsa000610.11542588
134AMPK signaling pathway_Homo sapiens_hsa041520.10657732
135Hedgehog signaling pathway_Homo sapiens_hsa043400.10263167
136Butanoate metabolism_Homo sapiens_hsa006500.09032834
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.09027583
138Hippo signaling pathway_Homo sapiens_hsa043900.08917480
139HTLV-I infection_Homo sapiens_hsa051660.08323872
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.06931018
141Tight junction_Homo sapiens_hsa045300.05446327
142Systemic lupus erythematosus_Homo sapiens_hsa053220.05328715
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03696514
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.02987420
145Glucagon signaling pathway_Homo sapiens_hsa049220.02532580
146Pyruvate metabolism_Homo sapiens_hsa006200.02387203
147HIF-1 signaling pathway_Homo sapiens_hsa040660.01581959
148Intestinal immune network for IgA production_Homo sapiens_hsa046720.00256714
149Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0470216
150Endocytosis_Homo sapiens_hsa04144-0.0432791
151Phototransduction_Homo sapiens_hsa04744-0.0322436
152Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0218683
153Retinol metabolism_Homo sapiens_hsa00830-0.0095095
154Lysosome_Homo sapiens_hsa04142-0.0070692
155Propanoate metabolism_Homo sapiens_hsa00640-0.0046035

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