SLC25A43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mitochondrial carrier family of proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)4.56878350
2COPI coating of Golgi vesicle (GO:0048205)4.53933098
3Golgi transport vesicle coating (GO:0048200)4.53933098
4desmosome organization (GO:0002934)4.50488608
5cell adhesion mediated by integrin (GO:0033627)4.12769491
6regulation of metalloenzyme activity (GO:0048552)3.94696064
7skin morphogenesis (GO:0043589)3.93533728
8response to peptidoglycan (GO:0032494)3.72213637
9dendritic cell chemotaxis (GO:0002407)3.59128160
10iron ion import (GO:0097286)3.55534979
11hemidesmosome assembly (GO:0031581)3.52681242
12regulation of nuclear cell cycle DNA replication (GO:0033262)3.49687978
13membrane raft organization (GO:0031579)3.47759000
14negative regulation of mast cell activation (GO:0033004)3.31397248
15pinocytosis (GO:0006907)3.29430939
16mesenchymal cell differentiation involved in renal system development (GO:2001012)3.26422558
17mesenchymal cell differentiation involved in kidney development (GO:0072161)3.26422558
18regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.26136865
19protein localization to endosome (GO:0036010)3.22483539
20dendritic cell migration (GO:0036336)3.15700932
21COPII vesicle coating (GO:0048208)3.14867492
22regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.14391848
23positive regulation of cellular amide metabolic process (GO:0034250)3.08134924
24hyaluronan catabolic process (GO:0030214)3.02203663
25positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.01428886
26negative regulation of DNA-dependent DNA replication (GO:2000104)3.00605030
27regulation of activation of Janus kinase activity (GO:0010533)3.00491690
28positive regulation of endothelial cell apoptotic process (GO:2000353)2.93753594
29tRNA methylation (GO:0030488)2.91376753
30cellular response to vitamin D (GO:0071305)2.91267955
31neutrophil activation involved in immune response (GO:0002283)2.91177720
32natural killer cell activation involved in immune response (GO:0002323)2.90153717
33sphingosine metabolic process (GO:0006670)2.88738943
34fibrinolysis (GO:0042730)2.88203158
35negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.86710157
36DNA strand renaturation (GO:0000733)2.86560776
37deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86495270
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.85097002
39negative regulation of protein localization to plasma membrane (GO:1903077)2.84779153
40positive regulation of keratinocyte differentiation (GO:0045618)2.84564992
41glycosphingolipid catabolic process (GO:0046479)2.83975137
42regulation of integrin-mediated signaling pathway (GO:2001044)2.83522864
43stress fiber assembly (GO:0043149)2.82836771
44G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.82182290
45regulation of dendritic cell antigen processing and presentation (GO:0002604)2.81888617
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79121059
47keratan sulfate catabolic process (GO:0042340)2.76852486
48regulation of extracellular matrix disassembly (GO:0010715)2.76778883
49adhesion of symbiont to host cell (GO:0044650)2.75002751
50virion attachment to host cell (GO:0019062)2.75002751
51regulation of mast cell activation (GO:0033003)2.74935249
52UDP-N-acetylglucosamine metabolic process (GO:0006047)2.74847588
53proteasome assembly (GO:0043248)2.74137018
54regulation of early endosome to late endosome transport (GO:2000641)2.73734970
55energy homeostasis (GO:0097009)2.72761182
56protein retention in ER lumen (GO:0006621)2.72498795
57epithelial cell-cell adhesion (GO:0090136)2.72496047
58barbed-end actin filament capping (GO:0051016)2.72483082
59type B pancreatic cell proliferation (GO:0044342)2.71181707
60superoxide metabolic process (GO:0006801)2.70988570
61positive regulation of extracellular matrix organization (GO:1903055)2.70723807
62platelet dense granule organization (GO:0060155)2.70598151
63regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.70518806
64replicative senescence (GO:0090399)2.70493552
65detection of molecule of bacterial origin (GO:0032490)2.69411075
66positive regulation by symbiont of host defense response (GO:0052509)2.69312576
67modulation by symbiont of host defense response (GO:0052031)2.69312576
68modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.69312576
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.69312576
70positive regulation by organism of defense response of other organism involved in symbiotic interact2.69312576
71modulation by symbiont of host immune response (GO:0052553)2.69312576
72cytochrome complex assembly (GO:0017004)2.68797196
73centriole assembly (GO:0098534)2.67613392
74cellular response to vitamin (GO:0071295)2.67592764
75hypotonic response (GO:0006971)2.67538315
76oligosaccharide catabolic process (GO:0009313)2.67187839
77hepatocyte apoptotic process (GO:0097284)2.66519516
78positive regulation of Cdc42 GTPase activity (GO:0043089)2.65922700
79cell-substrate junction assembly (GO:0007044)2.65369085
80regulation of mast cell degranulation (GO:0043304)2.65090568
81ceramide catabolic process (GO:0046514)2.64703311
82regulation of membrane protein ectodomain proteolysis (GO:0051043)2.64294947
83adhesion of symbiont to host (GO:0044406)2.63855100
84mammary gland epithelial cell proliferation (GO:0033598)2.63283005
85regulation of antigen processing and presentation (GO:0002577)2.60978312
86sphingoid metabolic process (GO:0046519)2.60804745
87histamine secretion (GO:0001821)2.60661284
88ganglion development (GO:0061548)2.58409569
89neutrophil activation (GO:0042119)2.58034680
90polyketide metabolic process (GO:0030638)2.57791249
91doxorubicin metabolic process (GO:0044598)2.57791249
92daunorubicin metabolic process (GO:0044597)2.57791249
93protein maturation by protein folding (GO:0022417)2.56992867
94regulation of transforming growth factor beta2 production (GO:0032909)2.56611804
95nucleotide-sugar biosynthetic process (GO:0009226)2.53888286
96detection of other organism (GO:0098543)2.53348454
97negative regulation of fatty acid transport (GO:2000192)2.52649649
98positive regulation of interleukin-1 beta secretion (GO:0050718)2.52643054
99positive regulation of monocyte chemotaxis (GO:0090026)2.52277753
100regulation of mast cell activation involved in immune response (GO:0033006)2.52164410
101positive regulation of antigen processing and presentation (GO:0002579)2.52073185
102regulation of water loss via skin (GO:0033561)2.51740403
103negative regulation of homotypic cell-cell adhesion (GO:0034111)2.51546998
104diol metabolic process (GO:0034311)2.51359659
105regulation of integrin activation (GO:0033623)2.50983732
106facial nerve structural organization (GO:0021612)2.50565511
107glycolipid catabolic process (GO:0019377)2.50501008
108positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50142441
109regulation of vitamin metabolic process (GO:0030656)2.48711612
110DNA catabolic process, exonucleolytic (GO:0000738)2.46849425
111positive regulation of receptor recycling (GO:0001921)2.46372597
112dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46036891
113DNA double-strand break processing (GO:0000729)2.45831397
114positive regulation of transforming growth factor beta production (GO:0071636)2.44506538
115fibril organization (GO:0097435)2.43672407
116cell differentiation involved in metanephros development (GO:0072202)2.43251871
117production of molecular mediator involved in inflammatory response (GO:0002532)2.42902326
118positive regulation of mast cell activation involved in immune response (GO:0033008)2.42454433
119positive regulation of mast cell degranulation (GO:0043306)2.42454433
120substrate-dependent cell migration (GO:0006929)2.42423312
121regulation of transforming growth factor beta1 production (GO:0032908)2.42058993
122branching involved in mammary gland duct morphogenesis (GO:0060444)2.42000046
123extracellular fibril organization (GO:0043206)2.41810801
124cellular response to exogenous dsRNA (GO:0071360)2.40359974
125apoptotic cell clearance (GO:0043277)2.40280055
126granulocyte activation (GO:0036230)2.39496315
127wound healing, spreading of epidermal cells (GO:0035313)2.39443500
128lipoxygenase pathway (GO:0019372)2.39031568
129regulation of timing of cell differentiation (GO:0048505)2.38283803
130retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.38158386
131replication fork processing (GO:0031297)2.36727882
132respiratory burst (GO:0045730)2.36714739
1337-methylguanosine mRNA capping (GO:0006370)2.36556003
134viral mRNA export from host cell nucleus (GO:0046784)2.36492675
135GPI anchor biosynthetic process (GO:0006506)2.36256948
136cellular response to interferon-beta (GO:0035458)2.35960184
137adenosine metabolic process (GO:0046085)2.35927997
138monocyte chemotaxis (GO:0002548)2.35717252
139vesicle coating (GO:0006901)2.35696573
140RNA capping (GO:0036260)2.35532948
1417-methylguanosine RNA capping (GO:0009452)2.35532948
142positive regulation of epidermal cell differentiation (GO:0045606)2.35241788
143regulation of mitochondrial translation (GO:0070129)2.35004423
144regulation of vitamin D biosynthetic process (GO:0060556)2.34360116
145positive regulation of T cell migration (GO:2000406)2.33840352
146fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.33350727
147cyclooxygenase pathway (GO:0019371)2.33231260
148preassembly of GPI anchor in ER membrane (GO:0016254)2.32260971
149regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.31973682
150regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.31703885
151endodermal cell differentiation (GO:0035987)2.31671279
152pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.30934593
153poly(A)+ mRNA export from nucleus (GO:0016973)2.30910566
154negative regulation of coagulation (GO:0050819)2.30439214
155peptidyl-glutamic acid carboxylation (GO:0017187)2.30333561
156protein carboxylation (GO:0018214)2.30333561
157regulation of superoxide metabolic process (GO:0090322)2.29835682
158DNA deamination (GO:0045006)2.29046443
159positive regulation of interleukin-1 secretion (GO:0050716)2.28654551
160respiratory chain complex IV assembly (GO:0008535)2.28438071
161regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.28373852
162regulation of mitotic spindle checkpoint (GO:1903504)2.28373852
163mesodermal cell differentiation (GO:0048333)2.28224217
164regulation of apoptotic process involved in morphogenesis (GO:1902337)2.27755421
165decidualization (GO:0046697)2.26860466
166regulation of double-strand break repair via homologous recombination (GO:0010569)2.26833826
167sequestering of extracellular ligand from receptor (GO:0035581)2.26073586
168negative regulation of keratinocyte proliferation (GO:0010839)2.25772161
169negative regulation of wound healing (GO:0061045)2.25723208
170startle response (GO:0001964)2.25563339
171rRNA methylation (GO:0031167)2.25460935
172negative regulation of smooth muscle cell migration (GO:0014912)2.25424213
173regulation of development, heterochronic (GO:0040034)2.25009202
174rRNA modification (GO:0000154)2.24961020
175negative regulation of hemostasis (GO:1900047)2.24819258
176negative regulation of blood coagulation (GO:0030195)2.24819258
177regulation of interleukin-8 secretion (GO:2000482)2.24619943
178kinetochore assembly (GO:0051382)2.24582605
179purinergic nucleotide receptor signaling pathway (GO:0035590)2.24379390
180platelet degranulation (GO:0002576)2.24222496
181response to muramyl dipeptide (GO:0032495)2.23943752
182positive regulation of mast cell activation (GO:0033005)2.23651453
183regulation of transforming growth factor beta production (GO:0071634)2.23446626
184positive regulation of type 2 immune response (GO:0002830)2.23151671
185maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.23126308
186developmental pigmentation (GO:0048066)2.22874763
187positive regulation of heat generation (GO:0031652)2.22407617
188negative regulation of viral genome replication (GO:0045071)2.22245709
189positive regulation of tissue remodeling (GO:0034105)2.21780218
190negative regulation of nitric oxide biosynthetic process (GO:0045019)2.21167789
191protein hydroxylation (GO:0018126)2.19620364
192negative regulation of anoikis (GO:2000811)2.18806453
193negative regulation of complement activation (GO:0045916)2.18561932
194peptidyl-proline hydroxylation (GO:0019511)2.17527477
195collagen fibril organization (GO:0030199)2.16874437
196establishment of skin barrier (GO:0061436)2.15972689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.66341804
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.49455137
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.95207921
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.40264863
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.29248589
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.21564900
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.13122924
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.76156297
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75092967
10GBX2_23144817_ChIP-Seq_PC3_Human2.72903020
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.70161085
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.59176184
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.56502368
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.54988410
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54106283
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46069670
17HIF1A_21447827_ChIP-Seq_MCF-7_Human2.45479584
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.41764759
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.41764759
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33714984
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.31076044
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.28003056
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.26522344
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.24550133
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.24196368
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21308999
27TP63_19390658_ChIP-ChIP_HaCaT_Human2.21078155
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20225547
29SUZ12_27294783_Chip-Seq_NPCs_Mouse2.15620124
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.12270223
31NFE2_27457419_Chip-Seq_LIVER_Mouse2.10593956
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10436868
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.09021441
34* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08497538
35GATA2_21666600_ChIP-Seq_HMVEC_Human2.06487571
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.05836523
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04770707
38PCGF2_27294783_Chip-Seq_NPCs_Mouse2.03095229
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.98974333
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.98745223
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96519336
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96381609
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95914054
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95741073
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.92899134
46ZNF263_19887448_ChIP-Seq_K562_Human1.91963970
47SOX2_20726797_ChIP-Seq_SW620_Human1.91725063
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90294133
49E2F7_22180533_ChIP-Seq_HELA_Human1.88071071
50* CJUN_26792858_Chip-Seq_BT549_Human1.87178793
51BRD4_25478319_ChIP-Seq_HGPS_Human1.86126500
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.82654359
53STAT3_18555785_Chip-Seq_ESCs_Mouse1.81222468
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.79885156
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78170675
56CLOCK_20551151_ChIP-Seq_293T_Human1.75345769
57SUZ12_18555785_Chip-Seq_ESCs_Mouse1.74049608
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.73403922
59IGF1R_20145208_ChIP-Seq_DFB_Human1.71892808
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.71848150
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70115188
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.69332481
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.68683273
64NMYC_18555785_Chip-Seq_ESCs_Mouse1.68670610
65E2F1_18555785_Chip-Seq_ESCs_Mouse1.67645415
66JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66868252
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.66322220
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64701537
69P53_22387025_ChIP-Seq_ESCs_Mouse1.64672329
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64586875
71PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62725114
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.61576636
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.61200545
74ATF3_27146783_Chip-Seq_COLON_Human1.60073352
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57590137
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57587562
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.57522061
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57028536
79P300_18555785_Chip-Seq_ESCs_Mouse1.55880171
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.55586285
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.53788755
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.52961291
83P63_26484246_Chip-Seq_KERATINOCYTES_Human1.52678222
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.52266826
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.51986903
86RUNX1_27457419_Chip-Seq_LIVER_Mouse1.51609510
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51550079
88LXR_22158963_ChIP-Seq_LIVER_Mouse1.50087148
89IRF1_19129219_ChIP-ChIP_H3396_Human1.49175757
90ZFX_18555785_Chip-Seq_ESCs_Mouse1.48332929
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48246860
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47874104
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.46894600
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.46425541
95SRF_21415370_ChIP-Seq_HL-1_Mouse1.45357925
96RACK7_27058665_Chip-Seq_MCF-7_Human1.45082598
97ELK1_19687146_ChIP-ChIP_HELA_Human1.44487040
98* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43465643
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42906577
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42813303
101KLF4_18555785_Chip-Seq_ESCs_Mouse1.42585203
102PU1_27457419_Chip-Seq_LIVER_Mouse1.40620281
103SMAD1_18555785_Chip-Seq_ESCs_Mouse1.40313112
104ESRRB_18555785_Chip-Seq_ESCs_Mouse1.39842583
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.39295764
106GATA6_25053715_ChIP-Seq_YYC3_Human1.39116487
107POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38928744
108CDX2_20551321_ChIP-Seq_CACO-2_Human1.37404385
109GABP_17652178_ChIP-ChIP_JURKAT_Human1.37176134
110P300_19829295_ChIP-Seq_ESCs_Human1.35847953
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35826403
112RNF2_27304074_Chip-Seq_NSC_Mouse1.35006081
113VDR_22108803_ChIP-Seq_LS180_Human1.33866472
114JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32830359
115GATA4_25053715_ChIP-Seq_YYC3_Human1.32795141
116CTCF_18555785_Chip-Seq_ESCs_Mouse1.32046598
117AR_21909140_ChIP-Seq_LNCAP_Human1.30797440
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29076118
119FOXO3_23340844_ChIP-Seq_DLD1_Human1.27737438
120TFEB_21752829_ChIP-Seq_HELA_Human1.26884846
121SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25663083
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25064288
123IRF8_27001747_Chip-Seq_BMDM_Mouse1.24633341
124GATA3_24758297_ChIP-Seq_MCF-7_Human1.23941129
125UBF1/2_26484160_Chip-Seq_HMECs_Human1.23766303
126FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23663146
127EWS_26573619_Chip-Seq_HEK293_Human1.23538770
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22379816
129SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22284315
130FUS_26573619_Chip-Seq_HEK293_Human1.21842027
131NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21455213
132TAL1_26923725_Chip-Seq_HPCs_Mouse1.21000953
133STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20560707
134FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19310946
135STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18541133
136EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18032687
137EGR1_19374776_ChIP-ChIP_THP-1_Human1.17841862
138BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17465403
139CRX_20693478_ChIP-Seq_RETINA_Mouse1.15370874
140ER_23166858_ChIP-Seq_MCF-7_Human1.15168043
141CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14942550
142HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14055471
143P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13144377
144KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11866355
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11704091
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10517554
147NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10517554
148PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08721993
149CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08622400
150AHR_22903824_ChIP-Seq_MCF-7_Human1.07833382
151LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07813120
152SCL_19346495_ChIP-Seq_HPC-7_Human1.07589894
153OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06963639
154NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06256892
155HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05771492
156MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05719519
157PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05473086
158EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05254152
159TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04445289
160SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04391810
161MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03770783
162SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03676740
163SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03039605
164STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01209106
165ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00910302
166CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00038128
167CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98602854
168TAF15_26573619_Chip-Seq_HEK293_Human0.97890174
169EST1_17652178_ChIP-ChIP_JURKAT_Human0.97830731
170MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97013938
171TP63_23658742_ChIP-Seq_EP156T_Human0.96760035
172RUNX1_22412390_ChIP-Seq_EML_Mouse0.96107101
173KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94676612
174STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94265232
175SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93253203
176ELF5_23300383_ChIP-Seq_T47D_Human0.92969437
177NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92922530
178FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92761263
179PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91996081
180SPI1_23547873_ChIP-Seq_NB4_Human0.91360458
181CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91162720
182PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89203232
183LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88146550
184TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87929712
185FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87206949
186VDR_23849224_ChIP-Seq_CD4+_Human0.87113219
187DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85850340
188TBX20_22328084_ChIP-Seq_HEART_Mouse0.85595820
189JUN_21703547_ChIP-Seq_K562_Human0.85164769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.18824527
2MP0003705_abnormal_hypodermis_morpholog3.55953846
3MP0006292_abnormal_olfactory_placode3.42256183
4MP0001835_abnormal_antigen_presentation3.17372603
5MP0001188_hyperpigmentation3.15205058
6MP0000566_synostosis2.92447445
7MP0003566_abnormal_cell_adhesion2.91687613
8MP0002277_abnormal_respiratory_mucosa2.84237208
9MP0010234_abnormal_vibrissa_follicle2.70643090
10MP0005257_abnormal_intraocular_pressure2.61505374
11MP0002877_abnormal_melanocyte_morpholog2.57683551
12MP0005275_abnormal_skin_tensile2.54699777
13MP0002148_abnormal_hypersensitivity_rea2.53543590
14MP0000015_abnormal_ear_pigmentation2.52810667
15MP0010352_gastrointestinal_tract_polyps2.47014602
16MP0002638_abnormal_pupillary_reflex2.41792773
17MP0005058_abnormal_lysosome_morphology2.38943181
18MP0005171_absent_coat_pigmentation2.36061855
19MP0002139_abnormal_hepatobiliary_system2.34236656
20MP0004782_abnormal_surfactant_physiolog2.31777348
21MP0010386_abnormal_urinary_bladder2.29585388
22MP0002132_abnormal_respiratory_system2.29484303
23MP0009785_altered_susceptibility_to2.25063550
24MP0003191_abnormal_cellular_cholesterol2.21231850
25MP0009840_abnormal_foam_cell2.19599023
26MP0008058_abnormal_DNA_repair2.19248863
27MP0003950_abnormal_plasma_membrane2.15202702
28MP0005671_abnormal_response_to2.13152695
29MP0002060_abnormal_skin_morphology2.12209140
30MP0002796_impaired_skin_barrier2.10801806
31MP0004272_abnormal_basement_membrane2.10341182
32MP0003724_increased_susceptibility_to2.08405066
33MP0005646_abnormal_pituitary_gland2.00005454
34MP0001958_emphysema1.95335333
35MP0005360_urolithiasis1.88898207
36MP0005023_abnormal_wound_healing1.88739206
37MP0003136_yellow_coat_color1.88093050
38MP0006054_spinal_hemorrhage1.87251069
39MP0003787_abnormal_imprinting1.87014012
40MP0009697_abnormal_copulation1.86267991
41MP0005075_abnormal_melanosome_morpholog1.85412950
42MP0005365_abnormal_bile_salt1.84943435
43MP0003941_abnormal_skin_development1.83658024
44MP0002419_abnormal_innate_immunity1.76990405
45MP0005645_abnormal_hypothalamus_physiol1.73526406
46MP0003252_abnormal_bile_duct1.73320914
47MP0002876_abnormal_thyroid_physiology1.71044660
48MP0005409_darkened_coat_color1.70949598
49MP0005000_abnormal_immune_tolerance1.67136280
50MP0002102_abnormal_ear_morphology1.64988234
51MP0005174_abnormal_tail_pigmentation1.64231943
52MP0000372_irregular_coat_pigmentation1.64071559
53MP0003453_abnormal_keratinocyte_physiol1.61160165
54MP0003279_aneurysm1.60477525
55MP0008007_abnormal_cellular_replicative1.60265235
56MP0001790_abnormal_immune_system1.59316633
57MP0005387_immune_system_phenotype1.59316633
58MP0003091_abnormal_cell_migration1.54029328
59MP0003300_gastrointestinal_ulcer1.53736594
60MP0005501_abnormal_skin_physiology1.52854886
61MP0005025_abnormal_response_to1.49111462
62MP0002095_abnormal_skin_pigmentation1.46389096
63MP0002452_abnormal_antigen_presenting1.44297984
64MP0001986_abnormal_taste_sensitivity1.43605084
65MP0008057_abnormal_DNA_replication1.41142029
66MP0005085_abnormal_gallbladder_physiolo1.41029140
67MP0001216_abnormal_epidermal_layer1.40036707
68MP0004947_skin_inflammation1.38435554
69MP0002396_abnormal_hematopoietic_system1.36290691
70MP0003786_premature_aging1.35364733
71MP0005451_abnormal_body_composition1.35117637
72MP0008260_abnormal_autophagy1.34503371
73MP0008789_abnormal_olfactory_epithelium1.33938608
74MP0002723_abnormal_immune_serum1.32034596
75MP0001186_pigmentation_phenotype1.30645669
76MP0004381_abnormal_hair_follicle1.29414206
77MP0004264_abnormal_extraembryonic_tissu1.28718861
78MP0006276_abnormal_autonomic_nervous1.27855126
79MP0001819_abnormal_immune_cell1.27499906
80MP0009780_abnormal_chondrocyte_physiolo1.27012309
81MP0008995_early_reproductive_senescence1.26862111
82MP0004233_abnormal_muscle_weight1.25167054
83MP0002420_abnormal_adaptive_immunity1.24935692
84MP0005503_abnormal_tendon_morphology1.24775782
85MP0002938_white_spotting1.24735090
86MP0001542_abnormal_bone_strength1.24007856
87MP0001800_abnormal_humoral_immune1.21110765
88MP0003436_decreased_susceptibility_to1.20053020
89MP0000343_altered_response_to1.17680326
90MP0003172_abnormal_lysosome_physiology1.17177175
91MP0005379_endocrine/exocrine_gland_phen1.15358445
92MP0001243_abnormal_dermal_layer1.13299336
93MP0002896_abnormal_bone_mineralization1.11718233
94MP0003868_abnormal_feces_composition1.11238186
95MP0004185_abnormal_adipocyte_glucose1.10737959
96MP0006082_CNS_inflammation1.10626338
97MP0002163_abnormal_gland_morphology1.10110382
98MP0001666_abnormal_nutrient_absorption1.09578312
99MP0005408_hypopigmentation1.09419689
100MP0010771_integument_phenotype1.07144946
101MP0009384_cardiac_valve_regurgitation1.06753541
102MP0004742_abnormal_vestibular_system1.06525316
103MP0005164_abnormal_response_to1.05833805
104MP0003186_abnormal_redox_activity1.05423288
105MP0000681_abnormal_thyroid_gland1.04888824
106MP0000569_abnormal_digit_pigmentation1.03475090
107MP0009764_decreased_sensitivity_to1.02675755
108MP0005499_abnormal_olfactory_system1.02171900
109MP0005394_taste/olfaction_phenotype1.02171900
110MP0003806_abnormal_nucleotide_metabolis1.01779979
111MP0005165_increased_susceptibility_to1.01587670
112MP0001533_abnormal_skeleton_physiology1.01224039
113MP0001346_abnormal_lacrimal_gland1.00144761
114MP0008004_abnormal_stomach_pH0.99457643
115MP0002006_tumorigenesis0.98223808
116MP0002405_respiratory_system_inflammati0.97266457
117MP0001984_abnormal_olfaction0.95872093
118MP0003763_abnormal_thymus_physiology0.95800471
119MP0000371_diluted_coat_color0.95619114
120MP0000049_abnormal_middle_ear0.94659510
121MP0001919_abnormal_reproductive_system0.94222176
122MP0010094_abnormal_chromosome_stability0.94121417
123MP0000858_altered_metastatic_potential0.94068688
124MP0010678_abnormal_skin_adnexa0.93375078
125MP0003075_altered_response_to0.93151565
126MP0000026_abnormal_inner_ear0.92366713
127MP0003718_maternal_effect0.91851978
128MP0005310_abnormal_salivary_gland0.91840615
129MP0005248_abnormal_Harderian_gland0.91379606
130MP0003111_abnormal_nucleus_morphology0.91110350
131MP0000678_abnormal_parathyroid_gland0.90175020
132MP0002075_abnormal_coat/hair_pigmentati0.89542033
133MP0000427_abnormal_hair_cycle0.89483534
134MP0001881_abnormal_mammary_gland0.88871037
135MP0000467_abnormal_esophagus_morphology0.88465469
136MP0000767_abnormal_smooth_muscle0.87089061
137MP0000627_abnormal_mammary_gland0.86884392
138MP0002751_abnormal_autonomic_nervous0.86335699
139MP0002177_abnormal_outer_ear0.86143122
140MP0001849_ear_inflammation0.85983665
141MP0001502_abnormal_circadian_rhythm0.85898145
142MP0005464_abnormal_platelet_physiology0.85787689
143MP0010368_abnormal_lymphatic_system0.85371457
144MP0001348_abnormal_lacrimal_gland0.84979004
145MP0000716_abnormal_immune_system0.84951618
146MP0003693_abnormal_embryo_hatching0.84938382
147MP0004510_myositis0.84441560
148MP0005076_abnormal_cell_differentiation0.83658620
149MP0000003_abnormal_adipose_tissue0.83129713
150MP0001119_abnormal_female_reproductive0.82891486
151MP0001905_abnormal_dopamine_level0.82664354
152MP0002398_abnormal_bone_marrow0.82142781
153MP0000609_abnormal_liver_physiology0.81878264
154MP0001853_heart_inflammation0.81428751
155MP0000013_abnormal_adipose_tissue0.80785158
156MP0000490_abnormal_crypts_of0.80756836
157MP0000685_abnormal_immune_system0.80712824
158MP0005389_reproductive_system_phenotype0.79869822
159MP0005084_abnormal_gallbladder_morpholo0.79457606
160MP0002166_altered_tumor_susceptibility0.78850531
161MP0002009_preneoplasia0.78849603
162MP0005375_adipose_tissue_phenotype0.78328436
163MP0005670_abnormal_white_adipose0.76630880
164MP0009333_abnormal_splenocyte_physiolog0.76317786
165MP0003795_abnormal_bone_structure0.75975059
166MP0002998_abnormal_bone_remodeling0.75016345
167MP0005390_skeleton_phenotype0.74575588
168MP0000377_abnormal_hair_follicle0.74068329
169MP0001764_abnormal_homeostasis0.73164021
170MP0003448_altered_tumor_morphology0.72540462
171MP0010155_abnormal_intestine_physiology0.71560731
172MP0000465_gastrointestinal_hemorrhage0.71477854
173MP0003656_abnormal_erythrocyte_physiolo0.71093612
174MP0008877_abnormal_DNA_methylation0.71035487
175MP0005666_abnormal_adipose_tissue0.71010633
176MP0001845_abnormal_inflammatory_respons0.70908632
177MP0010329_abnormal_lipoprotein_level0.70243911
178MP0001851_eye_inflammation0.69710795
179MP0002098_abnormal_vibrissa_morphology0.69509540
180MP0002118_abnormal_lipid_homeostasis0.68824528
181MP0009643_abnormal_urine_homeostasis0.68518639
182MP0009931_abnormal_skin_appearance0.67736356
183MP0005508_abnormal_skeleton_morphology0.67100261

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.73742689
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.52004287
3Protrusio acetabuli (HP:0003179)4.30354844
4Chromsome breakage (HP:0040012)3.99246111
5Vertebral compression fractures (HP:0002953)3.66769503
6Abnormality of liposaccharide metabolism (HP:0010968)3.63844037
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.63844037
8Abnormality of glycolipid metabolism (HP:0010969)3.63844037
9Recurrent abscess formation (HP:0002722)3.59402084
10Prostate neoplasm (HP:0100787)3.53057446
11Osteolytic defects of the phalanges of the hand (HP:0009771)3.19061258
12Osteolytic defects of the hand bones (HP:0009699)3.19061258
13Stomach cancer (HP:0012126)3.18868636
14Cervical subluxation (HP:0003308)3.10738248
15Vascular tortuosity (HP:0004948)3.08764017
16Dysostosis multiplex (HP:0000943)3.08465745
17Ankle contracture (HP:0006466)3.05401383
18Retrobulbar optic neuritis (HP:0100654)3.04144041
19Optic neuritis (HP:0100653)3.04144041
20Aortic dissection (HP:0002647)2.98402923
21Mucopolysacchariduria (HP:0008155)2.98057898
22Urinary glycosaminoglycan excretion (HP:0003541)2.98057898
23Follicular hyperkeratosis (HP:0007502)2.93106332
24Abnormality of the renal collecting system (HP:0004742)2.87775400
25Mitral stenosis (HP:0001718)2.86615643
26Duplicated collecting system (HP:0000081)2.84304425
27Abnormality of mucopolysaccharide metabolism (HP:0011020)2.83908585
28Abnormality of polysaccharide metabolism (HP:0011012)2.83908585
29Abnormality of glycosaminoglycan metabolism (HP:0004371)2.83908585
30Arterial tortuosity (HP:0005116)2.83680606
31Spondylolisthesis (HP:0003302)2.80428229
32Osteomalacia (HP:0002749)2.79747231
33Atrophic scars (HP:0001075)2.75653092
34Aortic aneurysm (HP:0004942)2.73454568
35Recurrent bacterial skin infections (HP:0005406)2.70554255
36Cardiovascular calcification (HP:0011915)2.68302530
37Alopecia of scalp (HP:0002293)2.67944214
38Aplasia/Hypoplasia of the fovea (HP:0008060)2.62331825
39Hypoplasia of the fovea (HP:0007750)2.62331825
40True hermaphroditism (HP:0010459)2.61666562
41Increased mean platelet volume (HP:0011877)2.61025440
42Loss of speech (HP:0002371)2.59654645
43J-shaped sella turcica (HP:0002680)2.58885911
44Conjugated hyperbilirubinemia (HP:0002908)2.58711322
45Renal cortical cysts (HP:0000803)2.51922413
46Vacuolated lymphocytes (HP:0001922)2.51339707
47Abnormality of incisor morphology (HP:0011063)2.47870533
48Fragile skin (HP:0001030)2.45941144
49Hypothermia (HP:0002045)2.45590753
50Type I transferrin isoform profile (HP:0003642)2.45163281
51Pancreatic fibrosis (HP:0100732)2.45088432
52Increased IgM level (HP:0003496)2.43043732
53Eczematoid dermatitis (HP:0000976)2.42516707
54Abnormality of the preputium (HP:0100587)2.41107779
55Wormian bones (HP:0002645)2.38529624
56Vascular calcification (HP:0004934)2.38336868
57Thin bony cortex (HP:0002753)2.34483638
58Obstructive lung disease (HP:0006536)2.33068587
59Chronic obstructive pulmonary disease (HP:0006510)2.33068587
60Myocardial infarction (HP:0001658)2.32216592
61Clubbing of toes (HP:0100760)2.32203480
62Abnormal platelet volume (HP:0011876)2.32142227
63Recurrent pneumonia (HP:0006532)2.29828653
64Abnormality of monocarboxylic acid metabolism (HP:0010996)2.29385264
65Aplasia cutis congenita (HP:0001057)2.28233900
66Abnormality of the prostate (HP:0008775)2.27415777
67Menorrhagia (HP:0000132)2.27257095
68Patchy hypopigmentation of hair (HP:0011365)2.26709944
69Orchitis (HP:0100796)2.25337596
70Bladder diverticulum (HP:0000015)2.23024244
71Dilatation of the ascending aorta (HP:0005111)2.22729207
72Neoplasm of the adrenal cortex (HP:0100641)2.20442935
73Intrahepatic cholestasis (HP:0001406)2.20355389
74White forelock (HP:0002211)2.19670801
75Short nail (HP:0001799)2.19416231
76Axonal loss (HP:0003447)2.18990697
77Type 2 muscle fiber atrophy (HP:0003554)2.18925882
78Septo-optic dysplasia (HP:0100842)2.17509103
79Abnormality of DNA repair (HP:0003254)2.14720821
80Xerostomia (HP:0000217)2.14255189
81Aplasia/Hypoplasia of the uvula (HP:0010293)2.14183350
82Abnormality of the Achilles tendon (HP:0005109)2.13970980
83Recurrent cutaneous fungal infections (HP:0011370)2.12741102
84Chronic mucocutaneous candidiasis (HP:0002728)2.12741102
85Ovoid vertebral bodies (HP:0003300)2.11996679
86Spinal rigidity (HP:0003306)2.11794933
87Optic nerve hypoplasia (HP:0000609)2.10504846
88Blue sclerae (HP:0000592)2.10323718
89Ectopic kidney (HP:0000086)2.09097026
90Achilles tendon contracture (HP:0001771)2.07890172
91Abnormality of the acetabulum (HP:0003170)2.06605808
92Purpura (HP:0000979)2.05252848
93Soft skin (HP:0000977)2.05067460
94Meckel diverticulum (HP:0002245)2.04712082
95Gingival bleeding (HP:0000225)2.04427280
96Elbow flexion contracture (HP:0002987)2.04304646
97Onycholysis (HP:0001806)2.03851071
98Abnormal delayed hypersensitivity skin test (HP:0002963)2.03747949
99Mediastinal lymphadenopathy (HP:0100721)2.03645868
100Tubulointerstitial nephritis (HP:0001970)2.02973800
101Preaxial hand polydactyly (HP:0001177)2.02352696
102Right ventricular cardiomyopathy (HP:0011663)2.01188103
103Conical tooth (HP:0000698)2.01054118
104Abnormality of the ileum (HP:0001549)2.01002674
105Gingivitis (HP:0000230)2.00620869
106Abnormality of chromosome stability (HP:0003220)1.99349792
107Thick nail (HP:0001805)1.99291367
108Congenital sensorineural hearing impairment (HP:0008527)1.98807459
109Abnormality of the fovea (HP:0000493)1.98787155
110Abnormality of the distal phalanges of the toes (HP:0010182)1.98478760
111Encephalitis (HP:0002383)1.98465422
112Cheilitis (HP:0100825)1.97799424
113Alveolar cell carcinoma (HP:0006519)1.97068458
114Myositis (HP:0100614)1.96902351
115Prolonged neonatal jaundice (HP:0006579)1.95784658
116Pancreatic cysts (HP:0001737)1.94967200
117Pulmonary artery stenosis (HP:0004415)1.93799708
118Prolonged bleeding time (HP:0003010)1.92935988
119Hydroxyprolinuria (HP:0003080)1.92817043
120Abnormality of proline metabolism (HP:0010907)1.92817043
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92767808
122Abnormality of glutamine family amino acid metabolism (HP:0010902)1.92761605
123Abnormal hair whorl (HP:0010721)1.91991800
124Median cleft lip (HP:0000161)1.91192416
125Tetraparesis (HP:0002273)1.90607214
1263-Methylglutaconic aciduria (HP:0003535)1.88911448
127Xanthomatosis (HP:0000991)1.87399495
128Systemic lupus erythematosus (HP:0002725)1.86823070
129Chronic hepatic failure (HP:0100626)1.86668256
130Plantar hyperkeratosis (HP:0007556)1.85204036
131Petechiae (HP:0000967)1.84415644
132Peritonitis (HP:0002586)1.84270121
133Aortic regurgitation (HP:0001659)1.83603787
134Recurrent fungal infections (HP:0002841)1.82995746
135Reduced antithrombin III activity (HP:0001976)1.82877250
136Asymmetry of the thorax (HP:0001555)1.82840158
137Mitral regurgitation (HP:0001653)1.82595992
138Recurrent lower respiratory tract infections (HP:0002783)1.82441103
139Bone pain (HP:0002653)1.81819844
140Submucous cleft hard palate (HP:0000176)1.81438983
141Renal Fanconi syndrome (HP:0001994)1.80928350
142Fat malabsorption (HP:0002630)1.80630930
143Abnormality of the common coagulation pathway (HP:0010990)1.80170194
144Deep venous thrombosis (HP:0002625)1.80096475
145Upper limb amyotrophy (HP:0009129)1.78541340
146Distal upper limb amyotrophy (HP:0007149)1.78541340
147Keratoconjunctivitis sicca (HP:0001097)1.78048818
148Generalized amyotrophy (HP:0003700)1.77675736
149Flat acetabular roof (HP:0003180)1.77406905
150Absent frontal sinuses (HP:0002688)1.77330844
151Meningitis (HP:0001287)1.76929575
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76558910
153Abnormality of the incisor (HP:0000676)1.75882712
154Optic nerve coloboma (HP:0000588)1.75874591
155Microglossia (HP:0000171)1.75721021
156Genu recurvatum (HP:0002816)1.75052760
157Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74442081
158Male pseudohermaphroditism (HP:0000037)1.74047504
159Palmoplantar hyperkeratosis (HP:0000972)1.73668392
160Protruding tongue (HP:0010808)1.73373697
161Recurrent skin infections (HP:0001581)1.73236190
162Abnormality of macrophages (HP:0004311)1.72721881
163Aneurysm (HP:0002617)1.72466833
164Birth length less than 3rd percentile (HP:0003561)1.72303116
165Oligohydramnios (HP:0001562)1.72222686
166Natal tooth (HP:0000695)1.72034999
167Protuberant abdomen (HP:0001538)1.71593621
168Aplasia/Hypoplasia of the tibia (HP:0005772)1.71475810
169Intestinal atresia (HP:0011100)1.71011099
170Distal lower limb muscle weakness (HP:0009053)1.70361850
171Cardiomegaly (HP:0001640)1.68124568
172Hypergonadotropic hypogonadism (HP:0000815)1.67923485
173Joint stiffness (HP:0001387)1.67877445
174Coarse hair (HP:0002208)1.67847630
175Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.67694543
176Long toe (HP:0010511)1.66992603
177Bone marrow hypocellularity (HP:0005528)1.66312010
178Medial flaring of the eyebrow (HP:0010747)1.66279329
179Abnormal platelet function (HP:0011869)1.66213018
180Impaired platelet aggregation (HP:0003540)1.66213018
181Keratoconjunctivitis (HP:0001096)1.65898244
182Cerebral aneurysm (HP:0004944)1.65861916
183Abdominal distention (HP:0003270)1.65696834
184Abnormality of renal resorption (HP:0011038)1.65444391
185Abnormal protein glycosylation (HP:0012346)1.65406347
186Abnormal glycosylation (HP:0012345)1.65406347
187Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65406347
188Abnormal protein N-linked glycosylation (HP:0012347)1.65406347
189Deformed sella turcica (HP:0002681)1.65403522
190Orthostatic hypotension (HP:0001278)1.65400822
191Panhypogammaglobulinemia (HP:0003139)1.64412113
192Fair hair (HP:0002286)1.64212747
193Malnutrition (HP:0004395)1.64055593
194Glomerulopathy (HP:0100820)1.63947133
195Absent/shortened dynein arms (HP:0200106)1.63467144
196Dynein arm defect of respiratory motile cilia (HP:0012255)1.63467144
197Increased serum ferritin (HP:0003281)1.62798610
198Occipital encephalocele (HP:0002085)1.62082803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.22364259
2MST1R3.76169461
3IRAK33.68027366
4IRAK43.17263232
5MAP3K142.79821563
6STK162.79308834
7NEK92.67378019
8EIF2AK12.63133666
9TESK12.60509364
10ERN12.42856957
11TXK2.40362744
12CASK2.33052990
13SCYL22.26428750
14MET2.25449334
15PLK42.24149917
16MKNK22.23262513
17BMPR22.16105929
18PAK42.15188437
19PDGFRA1.96420482
20PBK1.92094142
21TRIB31.89883660
22PTK21.84715106
23ADRBK21.82145114
24ERBB31.79626814
25YES11.78627959
26MKNK11.76028092
27TGFBR21.75339449
28SIK31.74782331
29SRPK11.74591680
30TNIK1.73069091
31EIF2AK21.65708873
32DDR21.62077567
33BMPR1B1.61491552
34PRPF4B1.56642270
35SIK11.54338287
36BLK1.53580190
37ABL21.44023706
38TEC1.42784809
39LIMK11.42292710
40IKBKE1.42196620
41ILK1.41805398
42STK38L1.41305630
43MAP3K31.40548619
44VRK11.33321957
45MAPKAPK31.33289385
46MAP2K71.30344486
47IRAK21.28457624
48IKBKB1.28065097
49AKT31.26597166
50PINK11.24859883
51LMTK21.24751524
52PIM21.22898000
53EPHA21.20707029
54BMX1.15764686
55NUAK11.15477568
56IRAK11.15323205
57ERBB41.14643503
58TTN1.13449671
59ARAF1.12004930
60TNK21.11505966
61SGK21.10172674
62GRK71.09814958
63STK31.05429765
64MAPK131.05195442
65CDK31.04654500
66NEK11.03656812
67MST41.01632826
68ICK1.00983036
69NEK61.00359555
70CLK10.99733193
71TAOK20.98480411
72INSRR0.97275814
73MAP3K60.96374055
74GRK10.95545543
75LATS20.93945713
76NLK0.93083193
77CHUK0.92708474
78JAK30.91265592
79BRD40.90760713
80PRKG20.89712794
81LATS10.87404874
82MAP3K20.86877041
83DMPK0.86791684
84TYK20.85785760
85PKN20.85586285
86RIPK10.85504919
87TTK0.85472737
88JAK10.84125197
89BUB10.84116790
90MELK0.83540862
91PLK30.83040334
92RPS6KB20.82708049
93PAK20.82360002
94STK240.81007916
95SMG10.80523093
96CDC42BPA0.79775883
97PDGFRB0.78218791
98MOS0.77973719
99ATR0.77467644
100STK40.75751738
101EPHB20.75478030
102MUSK0.75317152
103CCNB10.75063110
104CDK80.74594668
105PTK2B0.73851968
106EPHB10.73587723
107BTK0.73273435
108PDPK10.73152386
109KIT0.72812853
110DYRK20.72760091
111MAPKAPK20.71840272
112MAPK110.71602301
113NME20.71323065
114STK100.70403906
115MAP2K30.70220568
116LYN0.68257367
117CSF1R0.66836990
118RIPK40.65913904
119PIM10.65334265
120FER0.64529186
121ZAP700.62876293
122TRPM70.62323819
123TESK20.60603560
124RPS6KA40.60578405
125PLK20.60164672
126PIK3CG0.59281663
127BRAF0.57903495
128STK380.57545107
129MTOR0.55934937
130FLT30.55624446
131TBK10.55401490
132RPS6KA50.55223905
133ACVR1B0.53329428
134PIK3CA0.53289985
135SGK2230.51050485
136SGK4940.51050485
137TIE10.50572607
138MAP3K120.49466249
139EIF2AK30.48231901
140MAP2K10.48114087
141FGFR40.47911105
142SYK0.47696157
143CHEK20.46221738
144CDK70.45726508
145BCR0.45673822
146SGK30.44186804
147PRKCE0.43855847
148PRKCI0.42128852
149GSK3A0.41498491
150MAP3K80.41420371
151PAK10.41387922
152PRKD20.39587439
153PLK10.39372506
154MARK10.38235978
155RPS6KB10.37834747
156CDK60.37248860
157PRKCD0.35779008
158ABL10.34215910
159PTK60.34200514
160RAF10.34188368
161HCK0.33920567
162LCK0.33482758
163CAMK2D0.33297449
164EPHA30.32982592
165ROCK10.32957572
166ATM0.32599726
167MAPK70.31055455
168CSNK2A10.30839376
169DYRK1A0.30493992
170MYLK0.30142079
171PKN10.30112324
172TAOK30.28307045
173NTRK30.27974501
174MAPK150.27723801

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.71039794
2Fanconi anemia pathway_Homo sapiens_hsa034602.41159751
3Sulfur metabolism_Homo sapiens_hsa009202.37499540
4Graft-versus-host disease_Homo sapiens_hsa053322.34101228
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.23703305
6RNA polymerase_Homo sapiens_hsa030202.19484194
7Allograft rejection_Homo sapiens_hsa053302.07811514
8Homologous recombination_Homo sapiens_hsa034402.01081200
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.88144205
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.87833149
11Autoimmune thyroid disease_Homo sapiens_hsa053201.84430615
12Base excision repair_Homo sapiens_hsa034101.83186555
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81527878
14DNA replication_Homo sapiens_hsa030301.80799650
15ECM-receptor interaction_Homo sapiens_hsa045121.78566177
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.74400855
17Protein export_Homo sapiens_hsa030601.73948402
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71940826
19Basal transcription factors_Homo sapiens_hsa030221.70441512
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.66895690
21Rheumatoid arthritis_Homo sapiens_hsa053231.66133796
22Pyrimidine metabolism_Homo sapiens_hsa002401.65850188
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64867521
24Proteasome_Homo sapiens_hsa030501.60761020
25Non-homologous end-joining_Homo sapiens_hsa034501.60390665
26Pentose phosphate pathway_Homo sapiens_hsa000301.60184602
27Complement and coagulation cascades_Homo sapiens_hsa046101.55714798
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53976243
29Measles_Homo sapiens_hsa051621.53651036
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.52297282
31Galactose metabolism_Homo sapiens_hsa000521.51980280
32Focal adhesion_Homo sapiens_hsa045101.48423643
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.47546043
34Mismatch repair_Homo sapiens_hsa034301.45706278
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45082879
36Primary immunodeficiency_Homo sapiens_hsa053401.44013656
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43471041
38Nucleotide excision repair_Homo sapiens_hsa034201.43268941
39Leishmaniasis_Homo sapiens_hsa051401.41300428
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40601594
41Arachidonic acid metabolism_Homo sapiens_hsa005901.37057403
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36355812
43Small cell lung cancer_Homo sapiens_hsa052221.35229306
44Other glycan degradation_Homo sapiens_hsa005111.32708103
45Asthma_Homo sapiens_hsa053101.31885989
46Hematopoietic cell lineage_Homo sapiens_hsa046401.30257101
47Glutathione metabolism_Homo sapiens_hsa004801.29898851
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28952570
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28553832
50Proteoglycans in cancer_Homo sapiens_hsa052051.28301832
51Bladder cancer_Homo sapiens_hsa052191.27894681
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26238510
53Herpes simplex infection_Homo sapiens_hsa051681.25779791
54PPAR signaling pathway_Homo sapiens_hsa033201.25044907
55Fructose and mannose metabolism_Homo sapiens_hsa000511.24348108
56Type I diabetes mellitus_Homo sapiens_hsa049401.19210884
57Vibrio cholerae infection_Homo sapiens_hsa051101.15540820
58Starch and sucrose metabolism_Homo sapiens_hsa005001.15148940
59Amoebiasis_Homo sapiens_hsa051461.15061235
60Renin-angiotensin system_Homo sapiens_hsa046141.12795595
61Purine metabolism_Homo sapiens_hsa002301.11971986
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11563038
63Pancreatic cancer_Homo sapiens_hsa052121.11052024
64Chronic myeloid leukemia_Homo sapiens_hsa052201.08701414
65Legionellosis_Homo sapiens_hsa051341.08437473
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07907844
67Phagosome_Homo sapiens_hsa041451.06849161
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06070485
69Platelet activation_Homo sapiens_hsa046111.04702750
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03282578
71Influenza A_Homo sapiens_hsa051641.01673540
72Sphingolipid metabolism_Homo sapiens_hsa006001.01659714
73RNA degradation_Homo sapiens_hsa030181.00402053
74N-Glycan biosynthesis_Homo sapiens_hsa005100.99485064
75Retinol metabolism_Homo sapiens_hsa008300.98300184
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98230437
77Malaria_Homo sapiens_hsa051440.97622731
78Spliceosome_Homo sapiens_hsa030400.96421297
79Pertussis_Homo sapiens_hsa051330.95286108
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95060894
81Fatty acid elongation_Homo sapiens_hsa000620.94551420
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94170725
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.91295651
84Chemical carcinogenesis_Homo sapiens_hsa052040.88409900
85Regulation of autophagy_Homo sapiens_hsa041400.85885781
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.85214558
87Tuberculosis_Homo sapiens_hsa051520.84407612
88p53 signaling pathway_Homo sapiens_hsa041150.83294995
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.82829389
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.81489402
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.80953056
92TNF signaling pathway_Homo sapiens_hsa046680.78357691
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76257889
94Oxidative phosphorylation_Homo sapiens_hsa001900.75645575
95Caffeine metabolism_Homo sapiens_hsa002320.75028619
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73863742
97Nicotine addiction_Homo sapiens_hsa050330.73693958
98Thyroid cancer_Homo sapiens_hsa052160.73594346
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73389775
100Insulin resistance_Homo sapiens_hsa049310.73347812
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70161299
102Collecting duct acid secretion_Homo sapiens_hsa049660.68409049
103Acute myeloid leukemia_Homo sapiens_hsa052210.68199672
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68199188
105Renal cell carcinoma_Homo sapiens_hsa052110.67866402
106Osteoclast differentiation_Homo sapiens_hsa043800.67814841
107Staphylococcus aureus infection_Homo sapiens_hsa051500.67470211
108Adherens junction_Homo sapiens_hsa045200.67309920
109Fatty acid degradation_Homo sapiens_hsa000710.66990886
110Phototransduction_Homo sapiens_hsa047440.66099930
111Taste transduction_Homo sapiens_hsa047420.65676252
112Endocytosis_Homo sapiens_hsa041440.64924460
113Apoptosis_Homo sapiens_hsa042100.63440179
114Cell cycle_Homo sapiens_hsa041100.62686132
115Salmonella infection_Homo sapiens_hsa051320.61831825
116One carbon pool by folate_Homo sapiens_hsa006700.61276423
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60831168
118Ribosome_Homo sapiens_hsa030100.60771455
119Linoleic acid metabolism_Homo sapiens_hsa005910.60091050
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59816222
121African trypanosomiasis_Homo sapiens_hsa051430.59174185
122Ether lipid metabolism_Homo sapiens_hsa005650.59033602
123Chemokine signaling pathway_Homo sapiens_hsa040620.58927089
124Mineral absorption_Homo sapiens_hsa049780.58911444
125Epstein-Barr virus infection_Homo sapiens_hsa051690.58328818
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58316783
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52809698
128Huntingtons disease_Homo sapiens_hsa050160.51968686
129Serotonergic synapse_Homo sapiens_hsa047260.51923539
130Vitamin B6 metabolism_Homo sapiens_hsa007500.51787793
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.51720743
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51701193
133Lysosome_Homo sapiens_hsa041420.51107610
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50955733
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50077200
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.48558722
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48253603
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46752477
139RNA transport_Homo sapiens_hsa030130.44697649
140Antigen processing and presentation_Homo sapiens_hsa046120.43531598
141Hepatitis C_Homo sapiens_hsa051600.43430722
142Arginine biosynthesis_Homo sapiens_hsa002200.43074815
143Vitamin digestion and absorption_Homo sapiens_hsa049770.42451711
144Steroid biosynthesis_Homo sapiens_hsa001000.42113779
145Hepatitis B_Homo sapiens_hsa051610.42072798
146Toxoplasmosis_Homo sapiens_hsa051450.40980777
147TGF-beta signaling pathway_Homo sapiens_hsa043500.40084122
148Melanoma_Homo sapiens_hsa052180.39827199
149Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39441349
150Shigellosis_Homo sapiens_hsa051310.38057422
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37755429
152Maturity onset diabetes of the young_Homo sapiens_hsa049500.37327407
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37311506
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37138537
155Prostate cancer_Homo sapiens_hsa052150.36820313
156Fat digestion and absorption_Homo sapiens_hsa049750.36248917
157Parkinsons disease_Homo sapiens_hsa050120.35521726
158Viral myocarditis_Homo sapiens_hsa054160.35363458
159Carbon metabolism_Homo sapiens_hsa012000.34768975

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