SLC25A44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC25A44 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1coenzyme catabolic process (GO:0009109)5.70193017
2polyketide metabolic process (GO:0030638)4.99314244
3doxorubicin metabolic process (GO:0044598)4.99314244
4daunorubicin metabolic process (GO:0044597)4.99314244
5response to dietary excess (GO:0002021)4.80300637
6cellular modified amino acid catabolic process (GO:0042219)4.78004313
7sulfur amino acid catabolic process (GO:0000098)4.66875513
8L-phenylalanine catabolic process (GO:0006559)4.65058134
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.65058134
10L-phenylalanine metabolic process (GO:0006558)4.53709820
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.53709820
12negative regulation of cell killing (GO:0031342)4.53200158
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.53200158
14positive regulation by symbiont of host defense response (GO:0052509)4.48298333
15modulation by symbiont of host defense response (GO:0052031)4.48298333
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.48298333
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.48298333
18positive regulation by organism of defense response of other organism involved in symbiotic interact4.48298333
19modulation by symbiont of host immune response (GO:0052553)4.48298333
20biotin metabolic process (GO:0006768)4.27307698
21proline transport (GO:0015824)4.10447470
22macrophage activation involved in immune response (GO:0002281)4.06690736
23maintenance of protein location in nucleus (GO:0051457)4.03159874
24aromatic amino acid family catabolic process (GO:0009074)4.01291437
25heme transport (GO:0015886)3.97348622
26regulation of interferon-beta biosynthetic process (GO:0045357)3.92356620
27serine family amino acid catabolic process (GO:0009071)3.90323711
28cellular response to interleukin-15 (GO:0071350)3.82668466
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.77526368
30hormone catabolic process (GO:0042447)3.76933193
31cofactor catabolic process (GO:0051187)3.71447394
32negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.63037403
33cofactor transport (GO:0051181)3.56725429
34response to interleukin-15 (GO:0070672)3.55689279
35epoxygenase P450 pathway (GO:0019373)3.53198330
36kynurenine metabolic process (GO:0070189)3.52502870
37cysteine metabolic process (GO:0006534)3.50527223
38tryptophan catabolic process (GO:0006569)3.43848682
39indole-containing compound catabolic process (GO:0042436)3.43848682
40indolalkylamine catabolic process (GO:0046218)3.43848682
41phenol-containing compound catabolic process (GO:0019336)3.41450487
42negative regulation of interleukin-12 production (GO:0032695)3.41175760
43somite rostral/caudal axis specification (GO:0032525)3.40810166
44detection of molecule of bacterial origin (GO:0032490)3.33214443
45synaptic vesicle maturation (GO:0016188)3.32710076
46bile acid biosynthetic process (GO:0006699)3.31325925
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.31062071
48response to peptidoglycan (GO:0032494)3.29493501
49alpha-linolenic acid metabolic process (GO:0036109)3.28263993
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.26153279
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.25550435
52tryptophan metabolic process (GO:0006568)3.25453928
53aminoglycoside antibiotic metabolic process (GO:0030647)3.25400623
54drug metabolic process (GO:0017144)3.23261175
55cellular amino acid catabolic process (GO:0009063)3.21141236
56neutrophil mediated immunity (GO:0002446)3.19785451
57response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.19358044
58response to host immune response (GO:0052572)3.19358044
59urea cycle (GO:0000050)3.17413532
60urea metabolic process (GO:0019627)3.17413532
61aromatic amino acid family metabolic process (GO:0009072)3.14249498
62cellular extravasation (GO:0045123)3.12574227
63alpha-amino acid catabolic process (GO:1901606)3.09529577
64regulation of interleukin-12 biosynthetic process (GO:0045075)3.09298120
65iron coordination entity transport (GO:1901678)3.07588906
66detection of other organism (GO:0098543)3.07505188
67high-density lipoprotein particle remodeling (GO:0034375)3.05897054
68germinal center formation (GO:0002467)3.05849695
69bile acid metabolic process (GO:0008206)3.04512501
70quinone metabolic process (GO:1901661)3.02845688
71macrophage activation (GO:0042116)3.01688741
72leukocyte migration involved in inflammatory response (GO:0002523)3.01157579
73regulation of short-term neuronal synaptic plasticity (GO:0048172)3.00723538
74glutamate metabolic process (GO:0006536)2.97866520
75positive regulation of gamma-delta T cell activation (GO:0046645)2.97614624
76regulation of cilium movement (GO:0003352)2.97529288
77negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94992418
78cellular ketone body metabolic process (GO:0046950)2.93388283
79antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91806825
80tyrosine metabolic process (GO:0006570)2.91323367
81glyoxylate metabolic process (GO:0046487)2.90866452
82response to host defenses (GO:0052200)2.89462739
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.89462739
84response to host (GO:0075136)2.89462739
85glutamate secretion (GO:0014047)2.88629540
86triglyceride homeostasis (GO:0070328)2.88611240
87acylglycerol homeostasis (GO:0055090)2.88611240
88regulation of response to osmotic stress (GO:0047484)2.88388767
89production of molecular mediator involved in inflammatory response (GO:0002532)2.87726756
90glycine metabolic process (GO:0006544)2.87406826
91negative regulation of fibrinolysis (GO:0051918)2.87057765
92neutrophil activation (GO:0042119)2.87030988
93detection of external biotic stimulus (GO:0098581)2.86072331
94nitrogen cycle metabolic process (GO:0071941)2.85131684
95protein carboxylation (GO:0018214)2.84263160
96peptidyl-glutamic acid carboxylation (GO:0017187)2.84263160
97vitamin transmembrane transport (GO:0035461)2.82778720
98detection of bacterium (GO:0016045)2.82395669
99granulocyte activation (GO:0036230)2.81461291
100regulation of gamma-delta T cell activation (GO:0046643)2.80994142
101leukocyte aggregation (GO:0070486)2.80808697
102regulation of fibrinolysis (GO:0051917)2.79945805
103regulation of cellular amide metabolic process (GO:0034248)2.78556887
104microglial cell activation (GO:0001774)2.77574418
105regulation of B cell receptor signaling pathway (GO:0050855)2.77534512
106pyrimidine-containing compound transmembrane transport (GO:0072531)2.77238016
107regulation of MHC class I biosynthetic process (GO:0045343)2.77174350
108negative regulation of cAMP-mediated signaling (GO:0043951)2.76887333
109regulation of mammary gland epithelial cell proliferation (GO:0033599)2.76550239
110dicarboxylic acid biosynthetic process (GO:0043650)2.76540772
111homocysteine metabolic process (GO:0050667)2.76500628
112serine family amino acid metabolic process (GO:0009069)2.76479514
113negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.75046092
114regulation of protein activation cascade (GO:2000257)2.74770197
115complement activation, alternative pathway (GO:0006957)2.73777248
116respiratory burst (GO:0045730)2.71865326
117negative regulation of leukocyte mediated immunity (GO:0002704)2.70847737
118myeloid leukocyte mediated immunity (GO:0002444)2.70091179
119calcium-mediated signaling using intracellular calcium source (GO:0035584)2.69428427
120antigen processing and presentation of endogenous antigen (GO:0019883)2.69161853
121regulation of regulated secretory pathway (GO:1903305)2.68755680
122amino-acid betaine metabolic process (GO:0006577)2.68134099
123response to type I interferon (GO:0034340)2.66860674
124regulation of cholesterol esterification (GO:0010872)2.66412086
125negative regulation of telomerase activity (GO:0051974)2.65986426
126modified amino acid transport (GO:0072337)2.64642346
127type I interferon signaling pathway (GO:0060337)2.64516363
128cellular response to type I interferon (GO:0071357)2.64516363
129NIK/NF-kappaB signaling (GO:0038061)2.64350969
130negative regulation of T cell mediated immunity (GO:0002710)2.64161100
131lipopolysaccharide-mediated signaling pathway (GO:0031663)2.63473232
132rRNA transcription (GO:0009303)2.63465195
133CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.63380066
134T-helper cell differentiation (GO:0042093)2.63380066
135reverse cholesterol transport (GO:0043691)2.63367114
136positive regulation of regulated secretory pathway (GO:1903307)2.63231926
137flavonoid metabolic process (GO:0009812)2.62891227
138neutrophil activation involved in immune response (GO:0002283)2.61455155
139regulation of amyloid precursor protein catabolic process (GO:1902991)2.60906131
140regulation of cholesterol homeostasis (GO:2000188)2.60702016
141negative regulation of interleukin-6 production (GO:0032715)2.59880813
142fructose metabolic process (GO:0006000)2.58789019
143peroxisome fission (GO:0016559)2.58080958
144positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.57363259
145macromolecular complex remodeling (GO:0034367)2.56875577
146plasma lipoprotein particle remodeling (GO:0034369)2.56875577
147protein-lipid complex remodeling (GO:0034368)2.56875577
148organic acid catabolic process (GO:0016054)2.56703709
149carboxylic acid catabolic process (GO:0046395)2.56703709
150negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.56306205
151negative regulation of T-helper cell differentiation (GO:0045623)2.56306205
152phagosome maturation (GO:0090382)2.56100973
153acetyl-CoA metabolic process (GO:0006084)2.55000239
154regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.54774827
155lysine catabolic process (GO:0006554)2.54720972
156lysine metabolic process (GO:0006553)2.54720972
157gamma-aminobutyric acid transport (GO:0015812)2.54516436
158regulation of interferon-alpha production (GO:0032647)2.54464461
159interferon-gamma secretion (GO:0072643)2.53723485
160myeloid cell activation involved in immune response (GO:0002275)2.53654535
161mitochondrion distribution (GO:0048311)2.52831952
162L-ascorbic acid metabolic process (GO:0019852)2.52669911
163regulation of complement activation (GO:0030449)2.52073911
164indolalkylamine metabolic process (GO:0006586)2.51790096
165defense response to protozoan (GO:0042832)2.51693593
166antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.51449512
167interferon-gamma production (GO:0032609)2.51053558
168bile acid and bile salt transport (GO:0015721)2.50595360
169positive regulation of interferon-alpha production (GO:0032727)2.50354862
170branched-chain amino acid catabolic process (GO:0009083)2.49919330
171negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.49890560
172regulation of mast cell degranulation (GO:0043304)2.49849207
173synaptic vesicle exocytosis (GO:0016079)2.48708151
174regulation of T cell mediated cytotoxicity (GO:0001914)2.48584844
175receptor recycling (GO:0001881)2.48536637
176negative regulation of immunoglobulin mediated immune response (GO:0002890)2.47277481
177negative regulation of B cell mediated immunity (GO:0002713)2.47277481
178regulation of T-helper 2 cell differentiation (GO:0045628)2.44586824
179positive regulation of cellular amide metabolic process (GO:0034250)2.44507043
180positive regulation of T cell mediated cytotoxicity (GO:0001916)2.44326666
181response to muramyl dipeptide (GO:0032495)2.43898163
182positive regulation of granulocyte differentiation (GO:0030854)2.41284693
183negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.38271309
184immunoglobulin mediated immune response (GO:0016064)2.38147227
185detection of biotic stimulus (GO:0009595)2.37614375
186regulation of mast cell activation involved in immune response (GO:0033006)2.35861721
187regulation of leukocyte degranulation (GO:0043300)2.35603588
188positive regulation of interferon-beta production (GO:0032728)2.35117628
189regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.34945204
190negative regulation of Rho protein signal transduction (GO:0035024)2.34766200
191positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.34026453
192mitochondrion degradation (GO:0000422)2.33899546
193regulation of ARF protein signal transduction (GO:0032012)2.33535897
194positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.33384799
195regulation of myeloid leukocyte mediated immunity (GO:0002886)2.32353931
196alpha-beta T cell activation involved in immune response (GO:0002287)2.32326343
197T cell differentiation involved in immune response (GO:0002292)2.32326343
198alpha-beta T cell differentiation involved in immune response (GO:0002293)2.32326343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.02183887
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.29351260
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.95020330
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.95020330
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.95020330
6* RXR_22158963_ChIP-Seq_LIVER_Mouse3.93638465
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.21298114
8* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.20797989
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.13312562
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.03197954
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.77228582
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.76187727
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68031068
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.66841797
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.62628607
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.56302184
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40275242
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.36166655
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34478425
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.33906914
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.31730154
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.16933281
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15646359
24REST_21632747_ChIP-Seq_MESCs_Mouse2.11404984
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.10718767
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.05192042
27SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.03450086
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.02467401
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01478111
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.97249620
31SPI1_23127762_ChIP-Seq_K562_Human1.96091066
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.94705532
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.87900677
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86083410
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.84939821
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79025849
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.77339399
38MAF_26560356_Chip-Seq_TH1_Human1.75663076
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72736745
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.72605450
41MYC_22102868_ChIP-Seq_BL_Human1.71763311
42TCF3_18692474_ChIP-Seq_MESCs_Mouse1.70681236
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69004143
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67296397
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66288110
46SPI1_23547873_ChIP-Seq_NB4_Human1.66257946
47VDR_21846776_ChIP-Seq_THP-1_Human1.62975006
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.61188804
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.60575672
50* RUNX_20019798_ChIP-Seq_JUKART_Human1.59367619
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59214031
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58396629
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.57256630
54VDR_24763502_ChIP-Seq_THP-1_Human1.57080626
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.56254780
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56225521
57* MAF_26560356_Chip-Seq_TH2_Human1.55936100
58KDM2B_26808549_Chip-Seq_DND41_Human1.55127976
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54432009
60IRF1_19129219_ChIP-ChIP_H3396_Human1.52367803
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49086203
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47721880
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46182974
64TCF7_22412390_ChIP-Seq_EML_Mouse1.45722655
65NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.44312891
66BCOR_27268052_Chip-Seq_Bcells_Human1.43871214
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41515747
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41113595
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40765087
70NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.40553278
71TFEB_21752829_ChIP-Seq_HELA_Human1.39931233
72UTX_26944678_Chip-Seq_JUKART_Human1.39690726
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.39636572
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37813721
75* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37213118
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36204038
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36022551
78EZH2_22144423_ChIP-Seq_EOC_Human1.35508612
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35411831
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35258713
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33582571
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33150702
83* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33082442
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33058482
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32712256
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32255291
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30726311
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30681762
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.30658610
90* MYB_26560356_Chip-Seq_TH2_Human1.29578605
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27695717
92* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27432690
93* RACK7_27058665_Chip-Seq_MCF-7_Human1.25866177
94NANOG_16518401_ChIP-PET_MESCs_Mouse1.24954046
95PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24611208
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24476633
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23118614
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22803595
99* LXR_22292898_ChIP-Seq_THP-1_Human1.22215463
100CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21921072
101MYB_26560356_Chip-Seq_TH1_Human1.21018094
102RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20385415
103EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20385415
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19663419
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19441948
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19328328
107ELF1_20517297_ChIP-Seq_JURKAT_Human1.19324213
108VDR_24787735_ChIP-Seq_THP-1_Human1.16929016
109SMC4_20622854_ChIP-Seq_HELA_Human1.16604662
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.16094923
111E2F1_17053090_ChIP-ChIP_MCF-7_Human1.15969587
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.14738699
113* SA1_27219007_Chip-Seq_Bcells_Human1.14736283
114BCL6_27268052_Chip-Seq_Bcells_Human1.14681833
115SCL_19346495_ChIP-Seq_HPC-7_Human1.14282710
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14234734
117* KDM5A_27292631_Chip-Seq_BREAST_Human1.13765861
118ESR1_21235772_ChIP-Seq_MCF-7_Human1.13458319
119P68_20966046_ChIP-Seq_HELA_Human1.13132354
120SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12838812
121DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11521601
122CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11431855
123* GATA3_26560356_Chip-Seq_TH2_Human1.11324406
124STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10734876
125TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10044382
126GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10012005
127* ELK3_25401928_ChIP-Seq_HUVEC_Human1.09691234
128PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08268906
129FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08255641
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08055015
131GATA3_27048872_Chip-Seq_THYMUS_Human1.07865059
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07816569
133SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07732201
134ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07622702
135CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06844039
136GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05692807
137MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04965969
138TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04934733
139SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03520766
140NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02173588
141TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01842138
142TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01359999
143POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.01141605
144KDM2B_26808549_Chip-Seq_K562_Human1.00690237
145* EOMES_21245162_ChIP-Seq_HESCs_Human0.98768366
146PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95217427
147SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94071240
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93899112
149SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93562504
150GBX2_23144817_ChIP-Seq_PC3_Human0.93271820
151TET1_21490601_ChIP-Seq_MESCs_Mouse0.92306384
152TP63_19390658_ChIP-ChIP_HaCaT_Human0.92297776
153* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91289932
154ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88350863
155JARID2_20064375_ChIP-Seq_MESCs_Mouse0.86640503
156RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86448460
157JARID2_20075857_ChIP-Seq_MESCs_Mouse0.85173460
158THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84683891
159EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84419325
160RNF2_27304074_Chip-Seq_ESCs_Mouse0.84392515
161STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83987831
162ELK4_26923725_Chip-Seq_MESODERM_Mouse0.83237120
163* HNF4A_19822575_ChIP-Seq_HepG2_Human0.83212843
164SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81598724
165CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81330612
166RNF2_27304074_Chip-Seq_NSC_Mouse0.81296022
167STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.79496474
168RING1B_27294783_Chip-Seq_NPCs_Mouse0.77999660
169ZFP281_27345836_Chip-Seq_ESCs_Mouse0.77841380
170NANOG_18692474_ChIP-Seq_MEFs_Mouse0.77468757
171FOXA2_19822575_ChIP-Seq_HepG2_Human0.77238707
172* SMAD3_21741376_ChIP-Seq_HESCs_Human0.76521421
173ESET_19884257_ChIP-Seq_ESCs_Mouse0.76025313
174SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.75544797
175GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.74625353
176OCT4_19829295_ChIP-Seq_ESCs_Human0.74131026
177RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.74118287
178TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72970372
179SOX2_21211035_ChIP-Seq_LN229_Gbm0.72812394
180AR_19668381_ChIP-Seq_PC3_Human0.72617829
181OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72457371
182* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.71642712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.88180284
2MP0005360_urolithiasis3.98489028
3MP0005365_abnormal_bile_salt3.61453891
4MP0003011_delayed_dark_adaptation3.53113991
5MP0005085_abnormal_gallbladder_physiolo3.49962111
6MP0003436_decreased_susceptibility_to3.22143751
7MP0003724_increased_susceptibility_to3.19971034
8MP0008875_abnormal_xenobiotic_pharmacok3.17725679
9MP0003303_peritoneal_inflammation3.13592810
10MP0002254_reproductive_system_inflammat2.74574088
11MP0004859_abnormal_synaptic_plasticity2.62436754
12MP0004858_abnormal_nervous_system2.50356282
13MP0004264_abnormal_extraembryonic_tissu2.43205386
14MP0008260_abnormal_autophagy2.40922575
15MP0003172_abnormal_lysosome_physiology2.37177556
16MP0006292_abnormal_olfactory_placode2.36428760
17MP0004043_abnormal_pH_regulation2.32851074
18MP0010329_abnormal_lipoprotein_level2.27296401
19MP0009840_abnormal_foam_cell2.22304928
20MP0006035_abnormal_mitochondrial_morpho2.19057076
21MP0002419_abnormal_innate_immunity2.15610441
22MP0005499_abnormal_olfactory_system2.13366435
23MP0005394_taste/olfaction_phenotype2.13366435
24MP0003890_abnormal_embryonic-extraembry2.04172604
25MP0002822_catalepsy2.03699054
26MP0000685_abnormal_immune_system2.03663933
27MP0002332_abnormal_exercise_endurance2.00754286
28MP0009785_altered_susceptibility_to1.98522724
29MP0005310_abnormal_salivary_gland1.96146692
30MP0006082_CNS_inflammation1.95171321
31MP0004270_analgesia1.94607558
32MP0005025_abnormal_response_to1.92913785
33MP0005000_abnormal_immune_tolerance1.90542701
34MP0001800_abnormal_humoral_immune1.88395876
35MP0003635_abnormal_synaptic_transmissio1.85796850
36MP0005387_immune_system_phenotype1.83628654
37MP0001790_abnormal_immune_system1.83628654
38MP0009046_muscle_twitch1.81003334
39MP0005332_abnormal_amino_acid1.80915622
40MP0005671_abnormal_response_to1.79926230
41MP0002909_abnormal_adrenal_gland1.77833195
42MP0003329_amyloid_beta_deposits1.77679650
43MP0002723_abnormal_immune_serum1.76509564
44MP0001835_abnormal_antigen_presentation1.74079516
45MP0002064_seizures1.73864879
46MP0003880_abnormal_central_pattern1.72993602
47MP0003252_abnormal_bile_duct1.72309907
48MP0002148_abnormal_hypersensitivity_rea1.71770250
49MP0000015_abnormal_ear_pigmentation1.71533318
50MP0003806_abnormal_nucleotide_metabolis1.69559184
51MP0002138_abnormal_hepatobiliary_system1.67859685
52MP0001986_abnormal_taste_sensitivity1.67677135
53MP0004381_abnormal_hair_follicle1.65974951
54MP0002063_abnormal_learning/memory/cond1.64663153
55MP0003122_maternal_imprinting1.62655501
56MP0002572_abnormal_emotion/affect_behav1.62505380
57MP0003183_abnormal_peptide_metabolism1.61379614
58MP0001486_abnormal_startle_reflex1.60980752
59MP0004233_abnormal_muscle_weight1.60689942
60MP0002420_abnormal_adaptive_immunity1.59860063
61MP0001819_abnormal_immune_cell1.58661940
62MP0003195_calcinosis1.55889181
63MP0002452_abnormal_antigen_presenting1.53577881
64MP0004510_myositis1.52060611
65MP0002118_abnormal_lipid_homeostasis1.46918137
66MP0000609_abnormal_liver_physiology1.46635364
67MP0008961_abnormal_basal_metabolism1.46465891
68MP0001533_abnormal_skeleton_physiology1.46450730
69MP0009745_abnormal_behavioral_response1.43625353
70MP0004947_skin_inflammation1.41221464
71MP0003075_altered_response_to1.39071966
72MP0009764_decreased_sensitivity_to1.36504782
73MP0001501_abnormal_sleep_pattern1.36380255
74MP0002405_respiratory_system_inflammati1.29961887
75MP0005058_abnormal_lysosome_morphology1.29438289
76MP0005319_abnormal_enzyme/_coenzyme1.28242702
77MP0001440_abnormal_grooming_behavior1.24545332
78MP0002277_abnormal_respiratory_mucosa1.24249162
79MP0003879_abnormal_hair_cell1.23599863
80MP0002272_abnormal_nervous_system1.22845556
81MP0000716_abnormal_immune_system1.22594881
82MP0001845_abnormal_inflammatory_respons1.18807108
83MP0008469_abnormal_protein_level1.18764135
84MP0002876_abnormal_thyroid_physiology1.18750453
85MP0005423_abnormal_somatic_nervous1.16461084
86MP0003300_gastrointestinal_ulcer1.16289631
87MP0004019_abnormal_vitamin_homeostasis1.16076316
88MP0000604_amyloidosis1.15683919
89MP0002398_abnormal_bone_marrow1.15419964
90MP0005266_abnormal_metabolism1.15340587
91MP0005535_abnormal_body_temperature1.14607474
92MP0006036_abnormal_mitochondrial_physio1.13606504
93MP0003763_abnormal_thymus_physiology1.13167453
94MP0002734_abnormal_mechanical_nocicepti1.10369393
95MP0003938_abnormal_ear_development1.09940014
96MP0005257_abnormal_intraocular_pressure1.09841107
97MP0002733_abnormal_thermal_nociception1.09648527
98MP0002653_abnormal_ependyma_morphology1.09313556
99MP0008872_abnormal_physiological_respon1.09120855
100MP0003221_abnormal_cardiomyocyte_apopto1.04773541
101MP0002132_abnormal_respiratory_system1.04705242
102MP0001968_abnormal_touch/_nociception1.04443106
103MP0002078_abnormal_glucose_homeostasis1.04426376
104MP0004142_abnormal_muscle_tone1.03682429
105MP0000689_abnormal_spleen_morphology1.03472332
106MP0003787_abnormal_imprinting1.03154135
107MP0009333_abnormal_splenocyte_physiolog1.01835360
108MP0003705_abnormal_hypodermis_morpholog1.01350331
109MP0003690_abnormal_glial_cell1.01222617
110MP0003868_abnormal_feces_composition1.00279220
111MP0001666_abnormal_nutrient_absorption1.00003949
112MP0005075_abnormal_melanosome_morpholog0.99641412
113MP0002722_abnormal_immune_system0.98437805
114MP0000678_abnormal_parathyroid_gland0.97933924
115MP0005083_abnormal_biliary_tract0.97641547
116MP0005584_abnormal_enzyme/coenzyme_acti0.96577957
117MP0005551_abnormal_eye_electrophysiolog0.96221313
118MP0000920_abnormal_myelination0.94470783
119MP0002970_abnormal_white_adipose0.92947172
120MP0002429_abnormal_blood_cell0.92334552
121MP0004885_abnormal_endolymph0.91487654
122MP0003866_abnormal_defecation0.91055683
123MP0000955_abnormal_spinal_cord0.89975742
124MP0000703_abnormal_thymus_morphology0.89785275
125MP0005670_abnormal_white_adipose0.89233423
126MP0002229_neurodegeneration0.88997796
127MP0003191_abnormal_cellular_cholesterol0.88312823
128MP0002837_dystrophic_cardiac_calcinosis0.86925048
129MP0002127_abnormal_cardiovascular_syste0.86844030
130MP0005464_abnormal_platelet_physiology0.86312457
131MP0001970_abnormal_pain_threshold0.86217920
132MP0003656_abnormal_erythrocyte_physiolo0.85441251
133MP0005448_abnormal_energy_balance0.84552493
134MP0002090_abnormal_vision0.82024839
135MP0009780_abnormal_chondrocyte_physiolo0.80104123
136MP0003828_pulmonary_edema0.79775431
137MP0010155_abnormal_intestine_physiology0.77783234
138MP0001873_stomach_inflammation0.77310623
139MP0001851_eye_inflammation0.76499550
140MP0002693_abnormal_pancreas_physiology0.76004851
141MP0006276_abnormal_autonomic_nervous0.74506110
142MP0005452_abnormal_adipose_tissue0.74088258
143MP0005376_homeostasis/metabolism_phenot0.73532909
144MP0009765_abnormal_xenobiotic_induced0.73102383
145MP0002069_abnormal_eating/drinking_beha0.72673226
146MP0002066_abnormal_motor_capabilities/c0.72253241
147MP0003137_abnormal_impulse_conducting0.72096950
148MP0002067_abnormal_sensory_capabilities0.71217656
149MP0002269_muscular_atrophy0.70864268
150MP0002184_abnormal_innervation0.68468259
151MP0001905_abnormal_dopamine_level0.68392990
152MP0001661_extended_life_span0.68296510
153MP0005248_abnormal_Harderian_gland0.67381492
154MP0005451_abnormal_body_composition0.66354392
155MP0008874_decreased_physiological_sensi0.66093458
156MP0005386_behavior/neurological_phenoty0.65872634
157MP0004924_abnormal_behavior0.65872634
158MP0005379_endocrine/exocrine_gland_phen0.65041468
159MP0002971_abnormal_brown_adipose0.64350962
160MP0001529_abnormal_vocalization0.64128232
161MP0001984_abnormal_olfaction0.63436936

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.43561859
2Orchitis (HP:0100796)5.30775956
3Retrobulbar optic neuritis (HP:0100654)5.05555828
4Optic neuritis (HP:0100653)5.05555828
5Abnormality of the lower motor neuron (HP:0002366)5.01530700
6Myositis (HP:0100614)4.81713955
7Bilateral microphthalmos (HP:0007633)4.51508587
8Stomatitis (HP:0010280)4.31387608
9Hyperventilation (HP:0002883)4.27614611
10Hyperinsulinemic hypoglycemia (HP:0000825)4.15641285
11Hyperglycinuria (HP:0003108)4.10171317
12Hepatoblastoma (HP:0002884)3.95324842
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.95172003
14Gout (HP:0001997)3.88927989
15Hyperglycinemia (HP:0002154)3.84058375
16Tetraplegia (HP:0002445)3.74036152
17Multiple enchondromatosis (HP:0005701)3.69953026
18Abnormality of serine family amino acid metabolism (HP:0010894)3.64758333
19Abnormality of glycine metabolism (HP:0010895)3.64758333
20Eczematoid dermatitis (HP:0000976)3.62782335
21Intrahepatic cholestasis (HP:0001406)3.52495511
22Recurrent abscess formation (HP:0002722)3.50827997
23Xanthomatosis (HP:0000991)3.50672339
24Abnormality of macrophages (HP:0004311)3.50115995
25Abnormality of the intrinsic pathway (HP:0010989)3.46525874
26Deep venous thrombosis (HP:0002625)3.32368934
27Episodic fever (HP:0001954)3.24225849
28Recurrent bacterial skin infections (HP:0005406)3.20149902
29Increased cerebral lipofuscin (HP:0011813)3.17392746
30Increased neuronal autofluorescent lipopigment (HP:0002074)3.14868614
31Skin nodule (HP:0200036)3.11438655
32Testicular atrophy (HP:0000029)3.07615895
33Keratoconjunctivitis (HP:0001096)3.02081609
34Keratoconjunctivitis sicca (HP:0001097)3.01699172
35Status epilepticus (HP:0002133)2.99487429
36Abnormality of monocarboxylic acid metabolism (HP:0010996)2.98987210
37Prolonged partial thromboplastin time (HP:0003645)2.97903067
38Hyperlipoproteinemia (HP:0010980)2.96421453
39Focal motor seizures (HP:0011153)2.94890443
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.86851832
41Ketosis (HP:0001946)2.85375797
42Gastrointestinal infarctions (HP:0005244)2.77132610
43Abnormal cartilage morphology (HP:0002763)2.76672994
44Hyperammonemia (HP:0001987)2.75895635
45Dialeptic seizures (HP:0011146)2.75737195
46Epileptic encephalopathy (HP:0200134)2.75543000
47Anorexia (HP:0002039)2.75248871
48Spastic tetraparesis (HP:0001285)2.74641021
49Focal seizures (HP:0007359)2.73292843
50Ketoacidosis (HP:0001993)2.69857293
51Hypobetalipoproteinemia (HP:0003563)2.68884283
52Amyotrophic lateral sclerosis (HP:0007354)2.67032740
53Ragged-red muscle fibers (HP:0003200)2.64342178
54Ankle clonus (HP:0011448)2.61605312
55Abnormality of polysaccharide metabolism (HP:0011012)2.58441575
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.58441575
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.58441575
58Peripheral hypomyelination (HP:0007182)2.58207595
59Hypoplasia of the fovea (HP:0007750)2.53696027
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.53696027
61Elevated erythrocyte sedimentation rate (HP:0003565)2.52859503
62Malnutrition (HP:0004395)2.51802911
63Recurrent fungal infections (HP:0002841)2.51606829
64Generalized myoclonic seizures (HP:0002123)2.51103559
65Encephalitis (HP:0002383)2.50884386
66Irritability (HP:0000737)2.49972264
67Loss of speech (HP:0002371)2.49617109
68Generalized tonic-clonic seizures (HP:0002069)2.48832002
69Atonic seizures (HP:0010819)2.48224556
70Progressive inability to walk (HP:0002505)2.48036018
71Mediastinal lymphadenopathy (HP:0100721)2.46271411
72Febrile seizures (HP:0002373)2.45791457
73Hemiparesis (HP:0001269)2.45627287
74Slow saccadic eye movements (HP:0000514)2.45042718
75Upper motor neuron abnormality (HP:0002127)2.44790366
76Postural instability (HP:0002172)2.42525438
77Hypokinesia (HP:0002375)2.39812346
78Mutism (HP:0002300)2.39685269
79Albinism (HP:0001022)2.39362767
80Abnormality of the Achilles tendon (HP:0005109)2.37250782
81Visual hallucinations (HP:0002367)2.36401474
82Amblyopia (HP:0000646)2.36392729
83Hypochromic anemia (HP:0001931)2.34038516
84Supranuclear gaze palsy (HP:0000605)2.31527102
85Recurrent gram-negative bacterial infections (HP:0005420)2.29754038
86Hemoptysis (HP:0002105)2.29247886
87Absence seizures (HP:0002121)2.29227532
88Gingivitis (HP:0000230)2.28165369
89Hypoalphalipoproteinemia (HP:0003233)2.27381479
90Abnormality of the corticospinal tract (HP:0002492)2.26584899
91Cheilitis (HP:0100825)2.25766148
92Hypolipoproteinemia (HP:0010981)2.25490691
93Vasculitis (HP:0002633)2.25089143
94Complement deficiency (HP:0004431)2.24360750
95Recurrent skin infections (HP:0001581)2.23825672
96Abnormality of glycolysis (HP:0004366)2.23740235
97Increased serum pyruvate (HP:0003542)2.23740235
98Mucopolysacchariduria (HP:0008155)2.22974645
99Urinary glycosaminoglycan excretion (HP:0003541)2.22974645
100Urticaria (HP:0001025)2.21812302
101Resting tremor (HP:0002322)2.18535415
102Neurofibrillary tangles (HP:0002185)2.18091365
103Sensory axonal neuropathy (HP:0003390)2.17797165
104Global brain atrophy (HP:0002283)2.17670503
105Cerebral inclusion bodies (HP:0100314)2.16478327
106Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15796133
107Amyloidosis (HP:0011034)2.15701333
108Horizontal nystagmus (HP:0000666)2.15564603
109Abnormal delayed hypersensitivity skin test (HP:0002963)2.11601837
110Meningitis (HP:0001287)2.10371139
111Gingival bleeding (HP:0000225)2.09966940
112Anomalous pulmonary venous return (HP:0010772)2.09766800
113Progressive cerebellar ataxia (HP:0002073)2.09672052
114Achilles tendon contracture (HP:0001771)2.08749585
115Recurrent cutaneous fungal infections (HP:0011370)2.06795025
116Chronic mucocutaneous candidiasis (HP:0002728)2.06795025
117Abnormality of the endocardium (HP:0004306)2.06214216
118Dysostosis multiplex (HP:0000943)2.06006928
119Arterial thrombosis (HP:0004420)2.05189682
120Pulmonary infiltrates (HP:0002113)2.04802352
121Generalized hypotonia (HP:0001290)2.03496799
122Clumsiness (HP:0002312)2.03120859
123Progressive muscle weakness (HP:0003323)2.03119884
124Abnormal gallbladder physiology (HP:0012438)2.02962391
125Cholecystitis (HP:0001082)2.02962391
126Hypoglycemic coma (HP:0001325)2.01862890
127Abnormality of the fovea (HP:0000493)2.01589444
128Epidermoid cyst (HP:0200040)2.01571262
129Drooling (HP:0002307)1.99649920
130Excessive salivation (HP:0003781)1.99649920
131Keratitis (HP:0000491)1.98870694
132Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.98696198
133Inability to walk (HP:0002540)1.98280151
134Pulmonary embolism (HP:0002204)1.97418675
135Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96939830
136Progressive neurologic deterioration (HP:0002344)1.96648249
137Rib fusion (HP:0000902)1.96602354
138Spastic gait (HP:0002064)1.95828914
139Abnormality of sulfur amino acid metabolism (HP:0004339)1.95472042
140Severe global developmental delay (HP:0011344)1.95323791
141Metabolic acidosis (HP:0001942)1.94911112
142Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.94256220
143Absent speech (HP:0001344)1.93989153
144Agitation (HP:0000713)1.93370563
145Neuronal loss in central nervous system (HP:0002529)1.92744197
146Progressive external ophthalmoplegia (HP:0000590)1.92541074
147Joint hemorrhage (HP:0005261)1.91140176
148Gangrene (HP:0100758)1.90878324
149Abnormal gallbladder morphology (HP:0012437)1.90397130
150Decreased motor nerve conduction velocity (HP:0003431)1.90352785
151Ependymoma (HP:0002888)1.89630725
152Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88920506
153Abnormality of serum amino acid levels (HP:0003112)1.88504350
154Cholelithiasis (HP:0001081)1.88134999
155Chest pain (HP:0100749)1.87149451
156Abnormality of the pericardium (HP:0001697)1.87111026
157Hypercholesterolemia (HP:0003124)1.86954837
158Mitral stenosis (HP:0001718)1.86630960
159Morphological abnormality of the pyramidal tract (HP:0002062)1.86146566
160Ocular albinism (HP:0001107)1.85374743
161Bifid tongue (HP:0010297)1.85178483
162Lethargy (HP:0001254)1.84737789
163Delayed CNS myelination (HP:0002188)1.84200401
164Delusions (HP:0000746)1.83606501
165Abnormality of liposaccharide metabolism (HP:0010968)1.82308548
166Abnormality of glycosphingolipid metabolism (HP:0004343)1.82308548
167Abnormality of glycolipid metabolism (HP:0010969)1.82308548
168Neoplasm of striated muscle (HP:0009728)1.81923392
169Abnormality of purine metabolism (HP:0004352)1.81911591
170Myokymia (HP:0002411)1.80475559
171Limb hypertonia (HP:0002509)1.80453207
172Increased purine levels (HP:0004368)1.80380426
173Diplopia (HP:0000651)1.79274852
174Abnormality of binocular vision (HP:0011514)1.79274852
175Diminished motivation (HP:0000745)1.78211484
176Rigidity (HP:0002063)1.78190899
177Intellectual disability, progressive (HP:0006887)1.77820429
178Segmental peripheral demyelination/remyelination (HP:0003481)1.73783726
179Bradykinesia (HP:0002067)1.73678794
180Obstructive lung disease (HP:0006536)1.73538974
181Chronic obstructive pulmonary disease (HP:0006510)1.73538974
182Acne (HP:0001061)1.73258007
183Increased serum ferritin (HP:0003281)1.72799900
184Onion bulb formation (HP:0003383)1.72679691
185Muscle fibrillation (HP:0010546)1.69248789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK55.24993278
2CDK124.85552706
3GRK63.66456333
4ERN13.51190137
5EPHA43.05026085
6MAP2K32.80377729
7SIK22.77517367
8SIK32.68449243
9MAP2K42.64681090
10ADRBK22.62551034
11EPHB12.51730346
12TYRO32.51278233
13NTRK12.48780539
14GRK12.48513146
15NTRK32.47352522
16AKT32.33788571
17MAP3K92.32908771
18IRAK41.98517283
19MAP3K31.96502473
20TAOK21.95872532
21MAP2K61.88088809
22MAP4K11.83473010
23GRK71.78704624
24MAPK71.76084049
25TNK21.73343284
26MAP3K141.71129289
27MAP3K41.58797355
28LATS21.55449084
29BLK1.54474484
30WNK11.53707603
31PAK61.53364937
32TTK1.52487239
33CSF1R1.51314977
34BCKDK1.49665233
35FES1.46978445
36ZAP701.46244339
37MOS1.38498759
38TESK21.35398143
39CSK1.35326369
40INSRR1.35097491
41MARK21.34059415
42MAP3K111.30334166
43IKBKE1.29943426
44DAPK21.29657897
45TYK21.28807696
46MARK31.22712187
47TXK1.21406823
48MAP3K11.21269503
49NTRK21.20570784
50MAP3K61.17840230
51JAK21.17149564
52IRAK11.16930019
53PRKCG1.15797700
54CAMK41.15279525
55KSR21.14788279
56MAP3K51.14705732
57STK381.13709347
58TBK11.12539358
59CAMK1D1.11918419
60PRKD21.10007416
61SRPK11.09371013
62CHUK1.06773222
63MARK11.04476108
64FRK1.03094912
65HCK1.02501285
66ARAF0.97878154
67PRPF4B0.93750418
68CAMKK20.93102567
69BRD40.92830005
70MAP3K130.92360895
71ADRBK10.91450450
72MAP2K70.90830533
73ERBB40.89309309
74FGR0.89302167
75IKBKB0.88957890
76PAK30.87261145
77PRKD30.87072007
78SMG10.84568022
79SIK10.83381338
80IRAK30.83333594
81JAK30.83318841
82JAK10.82439083
83RIPK40.82274626
84MINK10.80921582
85MAPK120.80813270
86MATK0.80630058
87PINK10.80368029
88HIPK20.78238353
89CDK50.77176548
90PRKAA10.76797383
91SYK0.75485610
92YES10.72777584
93ALK0.71152893
94DYRK1A0.68821156
95EPHA30.67816178
96LMTK20.67083268
97IRAK20.64819721
98MAP3K70.64006360
99MAPK110.63253997
100SGK30.61627525
101ABL20.58874235
102PRKACG0.58763128
103PDK20.57601276
104TGFBR20.57030878
105TAOK30.56280091
106LCK0.56267678
107TAOK10.54510246
108ICK0.54165084
109PDK40.53727349
110PDK30.53727349
111MAPK100.53618624
112CASK0.52888947
113KSR10.51832981
114PRKG20.51279174
115CSNK1E0.51151683
116CDK150.51013726
117LYN0.50964362
118NEK60.50783397
119PTK20.50744125
120SGK4940.50396885
121SGK2230.50396885
122RPS6KA30.49759163
123CDC42BPA0.49260127
124OXSR10.48303422
125CHEK20.46543718
126CDK180.45731242
127SGK20.45522934
128CSNK1G20.45494778
129CAMKK10.45101992
130CAMK1G0.44746897
131STK100.44448589
132CAMK2A0.43749339
133DAPK10.43441326
134MAP3K20.43244628
135PRKACA0.43198925
136LRRK20.43028662
137CDK140.42841620
138PDK10.42825790
139RAF10.42697835
140BRAF0.40332581
141CAMK10.40232653
142AKT20.40173137
143CDK11A0.39715411
144PRKCZ0.39566078
145PRKCH0.39406214
146BTK0.38983424
147PRKCI0.38837995
148PLK20.38333213
149TRIB30.38180089
150PDPK10.37908649
151STK110.35299215
152FGFR30.35194643
153PRKAA20.33684627
154PLK10.33667402
155WNK30.33072517
156PRKACB0.32411616
157NME10.32046877
158PNCK0.30250484
159BRSK10.30221223
160IGF1R0.30202387
161DYRK20.28458980

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.27576692
2Nitrogen metabolism_Homo sapiens_hsa009102.97613520
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.89543540
4Osteoclast differentiation_Homo sapiens_hsa043802.49863617
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43168383
6Arginine biosynthesis_Homo sapiens_hsa002202.24971720
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.22582637
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.19774231
9Butanoate metabolism_Homo sapiens_hsa006502.15655607
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09261255
11Tryptophan metabolism_Homo sapiens_hsa003802.05527851
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02760450
13Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.88789928
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85901331
15Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.85082101
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.79760474
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79271213
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77124826
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.76837466
20Fructose and mannose metabolism_Homo sapiens_hsa000511.75699569
21Tuberculosis_Homo sapiens_hsa051521.72015914
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70151996
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68512206
24Complement and coagulation cascades_Homo sapiens_hsa046101.62805845
25Acute myeloid leukemia_Homo sapiens_hsa052211.60025742
26B cell receptor signaling pathway_Homo sapiens_hsa046621.57865342
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.51908896
28Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.49314703
29Leishmaniasis_Homo sapiens_hsa051401.49231856
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45868780
31PPAR signaling pathway_Homo sapiens_hsa033201.45509643
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43250250
33Fatty acid degradation_Homo sapiens_hsa000711.43000559
34Bile secretion_Homo sapiens_hsa049761.40758620
35GABAergic synapse_Homo sapiens_hsa047271.40601632
36Nicotine addiction_Homo sapiens_hsa050331.38953998
37T cell receptor signaling pathway_Homo sapiens_hsa046601.38176683
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38036511
39Lysosome_Homo sapiens_hsa041421.34449826
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34087856
41Vibrio cholerae infection_Homo sapiens_hsa051101.33987216
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32614101
43Fatty acid metabolism_Homo sapiens_hsa012121.28915682
44Legionellosis_Homo sapiens_hsa051341.28632769
45Chemical carcinogenesis_Homo sapiens_hsa052041.27820892
46Chemokine signaling pathway_Homo sapiens_hsa040621.26738253
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.26158686
48TNF signaling pathway_Homo sapiens_hsa046681.25366714
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.23714783
50Propanoate metabolism_Homo sapiens_hsa006401.22800321
51Dorso-ventral axis formation_Homo sapiens_hsa043201.22237707
52Peroxisome_Homo sapiens_hsa041461.20715303
53Hepatitis C_Homo sapiens_hsa051601.20001699
54Synaptic vesicle cycle_Homo sapiens_hsa047211.18848713
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17379676
56Folate biosynthesis_Homo sapiens_hsa007901.14267548
57Insulin resistance_Homo sapiens_hsa049311.12133860
58Glycerophospholipid metabolism_Homo sapiens_hsa005641.11443435
59Influenza A_Homo sapiens_hsa051641.10196023
60Biosynthesis of amino acids_Homo sapiens_hsa012301.08712834
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08677611
62Measles_Homo sapiens_hsa051621.07545684
63Carbon metabolism_Homo sapiens_hsa012001.07342110
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06925515
65beta-Alanine metabolism_Homo sapiens_hsa004101.06901624
66Phagosome_Homo sapiens_hsa041451.06268288
67Galactose metabolism_Homo sapiens_hsa000521.05653432
68Prolactin signaling pathway_Homo sapiens_hsa049171.04575675
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03736123
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03300142
71Regulation of autophagy_Homo sapiens_hsa041401.03241874
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02507068
73Cysteine and methionine metabolism_Homo sapiens_hsa002701.01144047
74Endocytosis_Homo sapiens_hsa041441.00282358
75Shigellosis_Homo sapiens_hsa051310.99348321
76Retinol metabolism_Homo sapiens_hsa008300.99206189
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.99023901
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97812429
79Pyruvate metabolism_Homo sapiens_hsa006200.97772827
80Glycerolipid metabolism_Homo sapiens_hsa005610.97618015
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97127273
82Glutamatergic synapse_Homo sapiens_hsa047240.95659946
83Non-small cell lung cancer_Homo sapiens_hsa052230.95557072
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95551535
85Histidine metabolism_Homo sapiens_hsa003400.95383336
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.94591327
87Renal cell carcinoma_Homo sapiens_hsa052110.94009476
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.93947077
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.93486763
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93423588
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93161414
92Hepatitis B_Homo sapiens_hsa051610.92687248
93African trypanosomiasis_Homo sapiens_hsa051430.91486358
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88198610
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.87653618
96Phenylalanine metabolism_Homo sapiens_hsa003600.86827392
97FoxO signaling pathway_Homo sapiens_hsa040680.86234169
98Selenocompound metabolism_Homo sapiens_hsa004500.85027733
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84765337
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84310982
101Sulfur metabolism_Homo sapiens_hsa009200.83817661
102Tyrosine metabolism_Homo sapiens_hsa003500.83756373
103Toxoplasmosis_Homo sapiens_hsa051450.83029663
104Linoleic acid metabolism_Homo sapiens_hsa005910.82008647
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81188473
106Starch and sucrose metabolism_Homo sapiens_hsa005000.81121283
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80851309
108Taste transduction_Homo sapiens_hsa047420.80151516
109ABC transporters_Homo sapiens_hsa020100.79032096
110Fatty acid elongation_Homo sapiens_hsa000620.77928729
111Fat digestion and absorption_Homo sapiens_hsa049750.77793459
112Circadian rhythm_Homo sapiens_hsa047100.77140739
113VEGF signaling pathway_Homo sapiens_hsa043700.76820079
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76175075
115GnRH signaling pathway_Homo sapiens_hsa049120.75983280
116MAPK signaling pathway_Homo sapiens_hsa040100.75059082
117Pentose phosphate pathway_Homo sapiens_hsa000300.74888673
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74143222
119Long-term potentiation_Homo sapiens_hsa047200.73113385
120Vitamin digestion and absorption_Homo sapiens_hsa049770.72887285
121Insulin secretion_Homo sapiens_hsa049110.70452352
122Herpes simplex infection_Homo sapiens_hsa051680.67648933
123Sulfur relay system_Homo sapiens_hsa041220.67309004
124Primary immunodeficiency_Homo sapiens_hsa053400.67063515
125Collecting duct acid secretion_Homo sapiens_hsa049660.66993521
126Apoptosis_Homo sapiens_hsa042100.66068192
127Pertussis_Homo sapiens_hsa051330.64942415
128Salmonella infection_Homo sapiens_hsa051320.64401416
129Fatty acid biosynthesis_Homo sapiens_hsa000610.63545548
130Allograft rejection_Homo sapiens_hsa053300.63310214
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.61245169
132Estrogen signaling pathway_Homo sapiens_hsa049150.61206837
133Amphetamine addiction_Homo sapiens_hsa050310.60939657
134Morphine addiction_Homo sapiens_hsa050320.59431336
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58472706
136mTOR signaling pathway_Homo sapiens_hsa041500.57400556
137Malaria_Homo sapiens_hsa051440.57334485
138Salivary secretion_Homo sapiens_hsa049700.57316933
139Insulin signaling pathway_Homo sapiens_hsa049100.57294756
140ErbB signaling pathway_Homo sapiens_hsa040120.55959282
141Choline metabolism in cancer_Homo sapiens_hsa052310.55409962
142Serotonergic synapse_Homo sapiens_hsa047260.54687579
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54554374
144Arginine and proline metabolism_Homo sapiens_hsa003300.53546638
145Circadian entrainment_Homo sapiens_hsa047130.53389938
146Steroid biosynthesis_Homo sapiens_hsa001000.52459929
147Rheumatoid arthritis_Homo sapiens_hsa053230.50070832
148Other glycan degradation_Homo sapiens_hsa005110.49614740
149Dopaminergic synapse_Homo sapiens_hsa047280.49463449
150Long-term depression_Homo sapiens_hsa047300.48538356
151Arachidonic acid metabolism_Homo sapiens_hsa005900.47509407
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46269636
153Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45936265
154Epstein-Barr virus infection_Homo sapiens_hsa051690.45276318
155Metabolic pathways_Homo sapiens_hsa011000.45009780
156AMPK signaling pathway_Homo sapiens_hsa041520.44716968
157Prion diseases_Homo sapiens_hsa050200.44584890
158Cyanoamino acid metabolism_Homo sapiens_hsa004600.44131942
159Type I diabetes mellitus_Homo sapiens_hsa049400.44001281
160Cocaine addiction_Homo sapiens_hsa050300.43385356
161Adipocytokine signaling pathway_Homo sapiens_hsa049200.42572230
162Ovarian steroidogenesis_Homo sapiens_hsa049130.42043382
163Caffeine metabolism_Homo sapiens_hsa002320.41765600
164Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41089433
165Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40997553
166Staphylococcus aureus infection_Homo sapiens_hsa051500.38698681
167Inositol phosphate metabolism_Homo sapiens_hsa005620.36535113
168Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36216525
169Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35149973
170Type II diabetes mellitus_Homo sapiens_hsa049300.34797024

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