SLC25A45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC25A45 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.15396651
2positive regulation of B cell differentiation (GO:0045579)5.06549818
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97484914
4antigen processing and presentation of endogenous antigen (GO:0019883)4.97189935
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.96854068
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.96854068
7regulation of B cell differentiation (GO:0045577)3.96751748
8regulation of interferon-beta biosynthetic process (GO:0045357)3.85124739
9behavioral response to nicotine (GO:0035095)3.77605204
10regulation of B cell receptor signaling pathway (GO:0050855)3.68152428
11immunoglobulin mediated immune response (GO:0016064)3.65993523
12positive regulation of gamma-delta T cell activation (GO:0046645)3.64650151
13positive regulation of interferon-alpha production (GO:0032727)3.61146183
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.56913249
15indolalkylamine metabolic process (GO:0006586)3.51535413
16positive regulation of defense response to virus by host (GO:0002230)3.51219716
17negative regulation of mast cell activation (GO:0033004)3.47968814
18fucose catabolic process (GO:0019317)3.46976615
19L-fucose metabolic process (GO:0042354)3.46976615
20L-fucose catabolic process (GO:0042355)3.46976615
21regulation of interferon-alpha production (GO:0032647)3.45287386
22neutrophil activation involved in immune response (GO:0002283)3.40165948
23adaptation of signaling pathway (GO:0023058)3.37470518
24sulfation (GO:0051923)3.33483775
25negative thymic T cell selection (GO:0045060)3.31579964
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.30985499
27negative T cell selection (GO:0043383)3.29411603
28regulation of interleukin-12 biosynthetic process (GO:0045075)3.27376780
29regulation of germinal center formation (GO:0002634)3.25214026
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.23866397
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20589300
32antigen processing and presentation via MHC class Ib (GO:0002475)3.20003039
33production of molecular mediator involved in inflammatory response (GO:0002532)3.18084601
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17866284
35indole-containing compound catabolic process (GO:0042436)3.14049349
36indolalkylamine catabolic process (GO:0046218)3.14049349
37tryptophan catabolic process (GO:0006569)3.14049349
38response to interferon-beta (GO:0035456)3.12528863
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11829345
40negative regulation of cell killing (GO:0031342)3.11829345
41cytidine metabolic process (GO:0046087)3.11478545
42cytidine catabolic process (GO:0006216)3.11478545
43cytidine deamination (GO:0009972)3.11478545
44B cell receptor signaling pathway (GO:0050853)3.09743231
45tolerance induction (GO:0002507)3.09501458
46cellular response to interleukin-15 (GO:0071350)3.05541099
47positive regulation of antigen processing and presentation (GO:0002579)3.04015866
48phospholipid efflux (GO:0033700)3.02312454
49cellular ketone body metabolic process (GO:0046950)3.02053750
50respiratory burst (GO:0045730)2.99798658
51positive regulation by symbiont of host defense response (GO:0052509)2.99262078
52modulation by symbiont of host defense response (GO:0052031)2.99262078
53modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.99262078
54modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.99262078
55positive regulation by organism of defense response of other organism involved in symbiotic interact2.99262078
56modulation by symbiont of host immune response (GO:0052553)2.99262078
57detection of light stimulus involved in sensory perception (GO:0050962)2.98532602
58detection of light stimulus involved in visual perception (GO:0050908)2.98532602
59regulation of regulatory T cell differentiation (GO:0045589)2.98332307
60regulation of cholesterol esterification (GO:0010872)2.97468061
61cellular response to interferon-beta (GO:0035458)2.96630925
62activated T cell proliferation (GO:0050798)2.92483689
63Arp2/3 complex-mediated actin nucleation (GO:0034314)2.92393990
64pinocytosis (GO:0006907)2.90768631
65regulation of gamma-delta T cell differentiation (GO:0045586)2.90395568
66aromatic amino acid family catabolic process (GO:0009074)2.90265225
67positive regulation of fatty acid transport (GO:2000193)2.90098339
68negative regulation of granulocyte differentiation (GO:0030853)2.89792471
69water-soluble vitamin biosynthetic process (GO:0042364)2.89168382
70tryptophan metabolic process (GO:0006568)2.88715778
71positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.88426196
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.87930013
73L-phenylalanine catabolic process (GO:0006559)2.87930013
74defense response to protozoan (GO:0042832)2.87170051
75mature B cell differentiation involved in immune response (GO:0002313)2.86708589
76macrophage activation involved in immune response (GO:0002281)2.86562307
77cellular response to type I interferon (GO:0071357)2.85534225
78type I interferon signaling pathway (GO:0060337)2.85534225
79negative regulation of telomere maintenance (GO:0032205)2.84568612
80myeloid dendritic cell activation (GO:0001773)2.84556104
81response to type I interferon (GO:0034340)2.84270196
82interferon-gamma production (GO:0032609)2.83985215
83protein polyglutamylation (GO:0018095)2.83529047
84pyrimidine ribonucleoside catabolic process (GO:0046133)2.81664402
85response to protozoan (GO:0001562)2.80113035
86piRNA metabolic process (GO:0034587)2.79593977
87rRNA catabolic process (GO:0016075)2.79110965
88regulation of memory T cell differentiation (GO:0043380)2.75477076
89mast cell activation (GO:0045576)2.74406888
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.74330659
91L-phenylalanine metabolic process (GO:0006558)2.74330659
92axoneme assembly (GO:0035082)2.71030574
93B cell mediated immunity (GO:0019724)2.69725988
94positive regulation of T cell differentiation in thymus (GO:0033089)2.68934746
95ketone body metabolic process (GO:1902224)2.68510736
96kynurenine metabolic process (GO:0070189)2.68154540
97negative regulation of erythrocyte differentiation (GO:0045647)2.67994497
98regulation of gamma-delta T cell activation (GO:0046643)2.67586573
99positive regulation of lipoprotein lipase activity (GO:0051006)2.65811824
100positive regulation of triglyceride lipase activity (GO:0061365)2.65811824
101preassembly of GPI anchor in ER membrane (GO:0016254)2.65553295
102response to peptidoglycan (GO:0032494)2.65149045
103mature B cell differentiation (GO:0002335)2.64664689
104alpha-linolenic acid metabolic process (GO:0036109)2.64501849
105mitochondrial respiratory chain complex I assembly (GO:0032981)2.64367821
106NADH dehydrogenase complex assembly (GO:0010257)2.64367821
107mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64367821
108cellular response to exogenous dsRNA (GO:0071360)2.64297745
109phosphatidylethanolamine biosynthetic process (GO:0006646)2.64175349
110cellular response to ATP (GO:0071318)2.63889552
111indole-containing compound metabolic process (GO:0042430)2.63274606
112RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63249086
113response to muramyl dipeptide (GO:0032495)2.62678896
114high-density lipoprotein particle remodeling (GO:0034375)2.61890035
115negative regulation of phagocytosis (GO:0050765)2.61349909
116phosphatidylethanolamine metabolic process (GO:0046337)2.61319222
117T-helper 1 type immune response (GO:0042088)2.60442336
118regulation of triglyceride catabolic process (GO:0010896)2.59969827
119myeloid cell activation involved in immune response (GO:0002275)2.59698601
120protein complex biogenesis (GO:0070271)2.58570556
121low-density lipoprotein particle remodeling (GO:0034374)2.58017159
122regulation of T cell mediated cytotoxicity (GO:0001914)2.57836338
123positive regulation of icosanoid secretion (GO:0032305)2.56976471
124myeloid dendritic cell differentiation (GO:0043011)2.56880655
125intestinal cholesterol absorption (GO:0030299)2.56469717
126mast cell activation involved in immune response (GO:0002279)2.56198011
127mast cell degranulation (GO:0043303)2.56198011
128platelet dense granule organization (GO:0060155)2.56120482
129positive regulation of T-helper 1 type immune response (GO:0002827)2.55686993
130complement activation, alternative pathway (GO:0006957)2.54259705
131response to interleukin-15 (GO:0070672)2.53146594
132interferon-gamma secretion (GO:0072643)2.51535863
133negative regulation of sterol transport (GO:0032372)2.51523269
134negative regulation of cholesterol transport (GO:0032375)2.51523269
135endoderm formation (GO:0001706)2.50961562
136positive regulation of interferon-beta production (GO:0032728)2.50393482
137cellular extravasation (GO:0045123)2.49732012
138plasma lipoprotein particle assembly (GO:0034377)2.49688690
139regulation of antigen processing and presentation (GO:0002577)2.48786729
140DNA methylation involved in gamete generation (GO:0043046)2.47919453
141urea metabolic process (GO:0019627)2.47082054
142urea cycle (GO:0000050)2.47082054
143amine catabolic process (GO:0009310)2.46888352
144cellular biogenic amine catabolic process (GO:0042402)2.46888352
145regulation of defense response to virus by host (GO:0050691)2.46258519
146microglial cell activation (GO:0001774)2.45936693
147negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.45878070
148negative regulation of T-helper cell differentiation (GO:0045623)2.45878070
149regulation of rhodopsin mediated signaling pathway (GO:0022400)2.45245327
150purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.43357181
1513-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.43357181
152plasma lipoprotein particle clearance (GO:0034381)2.43290526
153regulation of T cell receptor signaling pathway (GO:0050856)2.42168595
154somite development (GO:0061053)2.41706234
155interferon-gamma-mediated signaling pathway (GO:0060333)2.40316900
156regulation of action potential (GO:0098900)2.40210003
157negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.40107680
158protein-lipid complex assembly (GO:0065005)2.39858518
159detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39185438
160reverse cholesterol transport (GO:0043691)2.38947350
161response to pheromone (GO:0019236)2.38502665
162negative regulation of B cell proliferation (GO:0030889)2.38351852
163macrophage activation (GO:0042116)2.38275808
164positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.37956129
165positive thymic T cell selection (GO:0045059)2.37767591
166negative regulation of T cell mediated immunity (GO:0002710)2.37188267
167dendritic cell differentiation (GO:0097028)2.36924184
168positive regulation of T cell mediated cytotoxicity (GO:0001916)2.36821869
169neutrophil activation (GO:0042119)2.36683250
170positive regulation of oligodendrocyte differentiation (GO:0048714)2.36413868
171regulation of T-helper 1 type immune response (GO:0002825)2.36375836
172rhodopsin mediated signaling pathway (GO:0016056)2.36325970
173plasma lipoprotein particle remodeling (GO:0034369)2.36005844
174protein-lipid complex remodeling (GO:0034368)2.36005844
175macromolecular complex remodeling (GO:0034367)2.36005844
176positive regulation of prostaglandin secretion (GO:0032308)2.35541028
177sulfur amino acid catabolic process (GO:0000098)2.35324576
178NAD biosynthetic process (GO:0009435)2.34426361
179regulation of alpha-beta T cell proliferation (GO:0046640)2.34102475
180regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.33638535
181mannosylation (GO:0097502)2.33235883
182multicellular organism reproduction (GO:0032504)2.33052511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.23774916
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.43962830
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.94993575
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.62928651
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.35277390
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34704005
7ZNF274_21170338_ChIP-Seq_K562_Hela3.21048544
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12638280
9SCL_19346495_ChIP-Seq_HPC-7_Human3.04117745
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.95530352
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.95374818
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.88584924
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83992644
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.80928139
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.79762445
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78714784
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.77556178
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70167238
19* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.67958058
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.62364929
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.57183672
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.56248952
23VDR_22108803_ChIP-Seq_LS180_Human2.53361317
24EZH2_22144423_ChIP-Seq_EOC_Human2.31790663
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22273500
26* SPI1_23547873_ChIP-Seq_NB4_Human2.21855033
27VDR_21846776_ChIP-Seq_THP-1_Human2.21515563
28GATA1_22025678_ChIP-Seq_K562_Human2.21012426
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.18232967
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12683454
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12013253
32GBX2_23144817_ChIP-Seq_PC3_Human2.11786018
33STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10811442
34* LXR_22158963_ChIP-Seq_LIVER_Mouse2.08188040
35IGF1R_20145208_ChIP-Seq_DFB_Human2.04152492
36MAF_26560356_Chip-Seq_TH1_Human1.99759056
37* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.98683600
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97726752
39VDR_24763502_ChIP-Seq_THP-1_Human1.96812791
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96286895
41MYB_26560356_Chip-Seq_TH2_Human1.93257455
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.89774544
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85690133
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.85446471
45MYC_22102868_ChIP-Seq_BL_Human1.85256377
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.84538425
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83229938
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81800160
49MYB_26560356_Chip-Seq_TH1_Human1.79343471
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78373495
51RUNX_20019798_ChIP-Seq_JUKART_Human1.78351492
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77199845
53* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75438474
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74885919
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74568740
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70114088
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68810183
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67819182
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66618607
60* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66151535
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65018447
62* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63918210
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62783772
64ER_23166858_ChIP-Seq_MCF-7_Human1.62096192
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59934247
66* UTX_26944678_Chip-Seq_JUKART_Human1.55309557
67IRF1_19129219_ChIP-ChIP_H3396_Human1.52959432
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50210633
69* SPI1_23127762_ChIP-Seq_K562_Human1.49197536
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47726067
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47531611
72* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47050020
73TP53_22573176_ChIP-Seq_HFKS_Human1.46185789
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45813916
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42583664
76PU_27001747_Chip-Seq_BMDM_Mouse1.42510007
77TCF7_22412390_ChIP-Seq_EML_Mouse1.40888739
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39003922
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38198897
80E2F7_22180533_ChIP-Seq_HELA_Human1.37099710
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36587718
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35182410
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34777524
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33673278
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.32583302
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32256965
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30794699
88BCAT_22108803_ChIP-Seq_LS180_Human1.29518469
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29370793
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.29370793
91* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28899385
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28095938
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.26002658
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24499739
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.23410883
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23013064
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21501597
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21387341
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.21005918
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20852463
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.18869479
102TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18639036
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17274719
104P300_19829295_ChIP-Seq_ESCs_Human1.17183835
105NCOR_22424771_ChIP-Seq_293T_Human1.16621206
106MAF_26560356_Chip-Seq_TH2_Human1.16355389
107* AR_20517297_ChIP-Seq_VCAP_Human1.16234298
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15372695
109VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15223597
110STAT3_23295773_ChIP-Seq_U87_Human1.14971146
111GATA3_27048872_Chip-Seq_THYMUS_Human1.14573490
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13776229
113* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13030950
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12933274
115* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12708251
116NANOG_20526341_ChIP-Seq_ESCs_Human1.12460645
117NANOG_19829295_ChIP-Seq_ESCs_Human1.10989521
118SOX2_19829295_ChIP-Seq_ESCs_Human1.10989521
119ERA_21632823_ChIP-Seq_H3396_Human1.10721202
120EWS_26573619_Chip-Seq_HEK293_Human1.09526065
121HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09182268
122* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08921133
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08715949
124DROSHA_22980978_ChIP-Seq_HELA_Human1.08617833
125REST_21632747_ChIP-Seq_MESCs_Mouse1.08612460
126PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08362183
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08185566
128PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08171549
129* GATA3_26560356_Chip-Seq_TH2_Human1.07742954
130TCF4_23295773_ChIP-Seq_U87_Human1.07458898
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07353537
132BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06611493
133SMRT_27268052_Chip-Seq_Bcells_Human1.06567993
134MYC_18940864_ChIP-ChIP_HL60_Human1.06428289
135EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05818613
136TAF2_19829295_ChIP-Seq_ESCs_Human1.05058046
137ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03478706
138MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03106267
139NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02456016
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02188665
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01268208
142AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01255130
143HOXB7_26014856_ChIP-Seq_BT474_Human1.01209016
144CBP_20019798_ChIP-Seq_JUKART_Human1.00986376
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00986376
146UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00910326
147STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00689795
148HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00406894
149* ELK3_25401928_ChIP-Seq_HUVEC_Human1.00231527
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99829272
151STAT1_20625510_ChIP-Seq_HELA_Human0.98759385
152TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98583622
153PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98408552
154EZH2_27294783_Chip-Seq_NPCs_Mouse0.98017490
155MYC_19829295_ChIP-Seq_ESCs_Human0.97083639
156RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96258319
157GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96248061
158* AR_25329375_ChIP-Seq_VCAP_Human0.96247485
159CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96178087
160TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96073640
161FUS_26573619_Chip-Seq_HEK293_Human0.94941766
162* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94288081
163* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94044636
164* P300_27268052_Chip-Seq_Bcells_Human0.94035490
165OCT4_20526341_ChIP-Seq_ESCs_Human0.93463899
166CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93256753
167FLI1_21867929_ChIP-Seq_TH2_Mouse0.92176769
168TAF15_26573619_Chip-Seq_HEK293_Human0.91885028
169FOXH1_21741376_ChIP-Seq_ESCs_Human0.91499381
170KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91435209
171* GATA2_21666600_ChIP-Seq_HMVEC_Human0.89094348
172EGR1_19032775_ChIP-ChIP_M12_Human0.88038980
173GATA2_19941826_ChIP-Seq_K562_Human0.87878909
174BCL6_27268052_Chip-Seq_Bcells_Human0.87473755
175LXR_22292898_ChIP-Seq_THP-1_Human0.85383394
176KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85360316
177GATA1_19941826_ChIP-Seq_K562_Human0.85263051
178VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83674780
179SPI1_20517297_ChIP-Seq_HL60_Human0.82485945
180VDR_24787735_ChIP-Seq_THP-1_Human0.81191389
181* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.81002280
182TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77076030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.04523805
2MP0009840_abnormal_foam_cell3.54715256
3MP0005360_urolithiasis3.38394051
4MP0002139_abnormal_hepatobiliary_system2.90785984
5MP0005671_abnormal_response_to2.70621881
6MP0003436_decreased_susceptibility_to2.70249156
7MP0000685_abnormal_immune_system2.63006877
8MP0003191_abnormal_cellular_cholesterol2.55400777
9MP0009785_altered_susceptibility_to2.50575253
10MP0002876_abnormal_thyroid_physiology2.49717001
11MP0001986_abnormal_taste_sensitivity2.48582164
12MP0005646_abnormal_pituitary_gland2.42576646
13MP0002419_abnormal_innate_immunity2.41732958
14MP0005464_abnormal_platelet_physiology2.41325866
15MP0003195_calcinosis2.38916698
16MP0005025_abnormal_response_to2.38590224
17MP0001800_abnormal_humoral_immune2.36439816
18MP0001790_abnormal_immune_system2.30181087
19MP0005387_immune_system_phenotype2.30181087
20MP0005085_abnormal_gallbladder_physiolo2.29161992
21MP0002148_abnormal_hypersensitivity_rea2.28415765
22MP0005000_abnormal_immune_tolerance2.24999778
23MP0005058_abnormal_lysosome_morphology2.23860276
24MP0002837_dystrophic_cardiac_calcinosis2.21516167
25MP0002452_abnormal_antigen_presenting2.20560878
26MP0008877_abnormal_DNA_methylation2.19311313
27MP0005365_abnormal_bile_salt2.17749824
28MP0002102_abnormal_ear_morphology2.14382237
29MP0003724_increased_susceptibility_to2.13701187
30MP0006082_CNS_inflammation2.13293324
31MP0003646_muscle_fatigue2.13139939
32MP0002723_abnormal_immune_serum2.10728127
33MP0003252_abnormal_bile_duct1.97766279
34MP0002420_abnormal_adaptive_immunity1.96292605
35MP0001819_abnormal_immune_cell1.95891680
36MP0001968_abnormal_touch/_nociception1.94856016
37MP0001853_heart_inflammation1.93057107
38MP0002396_abnormal_hematopoietic_system1.88554045
39MP0008872_abnormal_physiological_respon1.87335059
40MP0008875_abnormal_xenobiotic_pharmacok1.86656586
41MP0005645_abnormal_hypothalamus_physiol1.80376962
42MP0003303_peritoneal_inflammation1.79857402
43MP0005551_abnormal_eye_electrophysiolog1.76910855
44MP0001873_stomach_inflammation1.76632123
45MP0003011_delayed_dark_adaptation1.72054129
46MP0008469_abnormal_protein_level1.70624647
47MP0001666_abnormal_nutrient_absorption1.68924562
48MP0004885_abnormal_endolymph1.66672053
49MP0001845_abnormal_inflammatory_respons1.66539013
50MP0010155_abnormal_intestine_physiology1.66208842
51MP0002398_abnormal_bone_marrow1.62417386
52MP0000689_abnormal_spleen_morphology1.62302227
53MP0000465_gastrointestinal_hemorrhage1.61951509
54MP0004130_abnormal_muscle_cell1.61524748
55MP0000716_abnormal_immune_system1.61285241
56MP0002405_respiratory_system_inflammati1.60280857
57MP0001501_abnormal_sleep_pattern1.60031080
58MP0002166_altered_tumor_susceptibility1.59766599
59MP0009764_decreased_sensitivity_to1.59022756
60MP0010329_abnormal_lipoprotein_level1.56291710
61MP0009333_abnormal_splenocyte_physiolog1.50127500
62MP0003300_gastrointestinal_ulcer1.48980468
63MP0004947_skin_inflammation1.44058761
64MP0003183_abnormal_peptide_metabolism1.43753009
65MP0002722_abnormal_immune_system1.43205441
66MP0002138_abnormal_hepatobiliary_system1.42100303
67MP0004147_increased_porphyrin_level1.39532709
68MP0002429_abnormal_blood_cell1.39209064
69MP0001533_abnormal_skeleton_physiology1.38588557
70MP0004145_abnormal_muscle_electrophysio1.37669559
71MP0004142_abnormal_muscle_tone1.37383391
72MP0000609_abnormal_liver_physiology1.34867192
73MP0003075_altered_response_to1.32917250
74MP0004043_abnormal_pH_regulation1.31667414
75MP0006072_abnormal_retinal_apoptosis1.31248690
76MP0005397_hematopoietic_system_phenotyp1.30223948
77MP0001545_abnormal_hematopoietic_system1.30223948
78MP0005174_abnormal_tail_pigmentation1.29496723
79MP0003763_abnormal_thymus_physiology1.29368659
80MP0009745_abnormal_behavioral_response1.25763657
81MP0003656_abnormal_erythrocyte_physiolo1.25274538
82MP0003787_abnormal_imprinting1.24359149
83MP0003172_abnormal_lysosome_physiology1.23252521
84MP0003866_abnormal_defecation1.22789473
85MP0004510_myositis1.21450429
86MP0001485_abnormal_pinna_reflex1.20188529
87MP0004808_abnormal_hematopoietic_stem1.19478853
88MP0002736_abnormal_nociception_after1.19303361
89MP0002277_abnormal_respiratory_mucosa1.15174544
90MP0000343_altered_response_to1.14995509
91MP0002006_tumorigenesis1.13944165
92MP0009278_abnormal_bone_marrow1.12415256
93MP0005389_reproductive_system_phenotype1.11801138
94MP0000569_abnormal_digit_pigmentation1.11791756
95MP0005083_abnormal_biliary_tract1.11600006
96MP0005584_abnormal_enzyme/coenzyme_acti1.11395065
97MP0003806_abnormal_nucleotide_metabolis1.11125354
98MP0002693_abnormal_pancreas_physiology1.11124670
99MP0005319_abnormal_enzyme/_coenzyme1.10464341
100MP0002163_abnormal_gland_morphology1.09572106
101MP0005253_abnormal_eye_physiology1.09392246
102MP0002653_abnormal_ependyma_morphology1.08991511
103MP0001764_abnormal_homeostasis1.08361831
104MP0000372_irregular_coat_pigmentation1.08240108
105MP0009763_increased_sensitivity_to1.07334470
106MP0003690_abnormal_glial_cell1.07241645
107MP0000604_amyloidosis1.06528300
108MP0004019_abnormal_vitamin_homeostasis1.06129439
109MP0001919_abnormal_reproductive_system1.06033622
110MP0000631_abnormal_neuroendocrine_gland1.05480255
111MP0005332_abnormal_amino_acid1.05279598
112MP0005166_decreased_susceptibility_to1.01830007
113MP0005670_abnormal_white_adipose1.00773180
114MP0005379_endocrine/exocrine_gland_phen0.99321139
115MP0000230_abnormal_systemic_arterial0.98524320
116MP0002272_abnormal_nervous_system0.98127857
117MP0009643_abnormal_urine_homeostasis0.97843658
118MP0005075_abnormal_melanosome_morpholog0.97582737
119MP0000490_abnormal_crypts_of0.97131797
120MP0002118_abnormal_lipid_homeostasis0.96961324
121MP0005310_abnormal_salivary_gland0.96924209
122MP0003283_abnormal_digestive_organ0.95114873
123MP0003186_abnormal_redox_activity0.93894417
124MP0006276_abnormal_autonomic_nervous0.92507436
125MP0000598_abnormal_liver_morphology0.92386143
126MP0000427_abnormal_hair_cycle0.90120915
127MP0002733_abnormal_thermal_nociception0.88334374
128MP0001765_abnormal_ion_homeostasis0.87347266
129MP0002933_joint_inflammation0.85523530
130MP0000858_altered_metastatic_potential0.84514138
131MP0001663_abnormal_digestive_system0.84116044
132MP0005410_abnormal_fertilization0.83915755
133MP0004381_abnormal_hair_follicle0.83683402
134MP0000703_abnormal_thymus_morphology0.83435627
135MP0002735_abnormal_chemical_nociception0.82489399
136MP0002928_abnormal_bile_duct0.82057260
137MP0002136_abnormal_kidney_physiology0.81205519
138MP0002254_reproductive_system_inflammat0.80641940
139MP0002638_abnormal_pupillary_reflex0.80493882
140MP0001970_abnormal_pain_threshold0.80240384
141MP0000249_abnormal_blood_vessel0.78378294
142MP0005084_abnormal_gallbladder_morpholo0.77634426
143MP0006292_abnormal_olfactory_placode0.77243862
144MP0003448_altered_tumor_morphology0.77236513
145MP0001486_abnormal_startle_reflex0.76718332
146MP0002064_seizures0.76564229
147MP0008775_abnormal_heart_ventricle0.75742775
148MP0002160_abnormal_reproductive_system0.75564731
149MP0004883_abnormal_blood_vessel0.73657146
150MP0009765_abnormal_xenobiotic_induced0.73279013
151MP0003879_abnormal_hair_cell0.73114972
152MP0002132_abnormal_respiratory_system0.71562917
153MP0009642_abnormal_blood_homeostasis0.70069698
154MP0008873_increased_physiological_sensi0.68928422
155MP0006054_spinal_hemorrhage0.67567877

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.30588433
2Recurrent abscess formation (HP:0002722)4.92082331
3Recurrent bacterial skin infections (HP:0005406)4.87667001
4Elevated erythrocyte sedimentation rate (HP:0003565)4.56402498
5Myositis (HP:0100614)4.25904497
6Chronic otitis media (HP:0000389)4.11426551
7Eczematoid dermatitis (HP:0000976)4.10264679
8Pancreatic cysts (HP:0001737)3.96709774
9Congenital stationary night blindness (HP:0007642)3.93260895
10Complement deficiency (HP:0004431)3.81321789
11Glomerulonephritis (HP:0000099)3.64269547
12Recurrent gram-negative bacterial infections (HP:0005420)3.62119551
13IgM deficiency (HP:0002850)3.61158762
14Orchitis (HP:0100796)3.39363495
15Thrombocytosis (HP:0001894)3.32995947
16Abolished electroretinogram (ERG) (HP:0000550)3.28301859
17Vacuolated lymphocytes (HP:0001922)3.25436694
18Recurrent viral infections (HP:0004429)3.25132660
19Recurrent skin infections (HP:0001581)3.24956745
20Abnormality of complement system (HP:0005339)3.22603331
21Stomatitis (HP:0010280)3.20132296
22Abnormality of the renal cortex (HP:0011035)3.17560214
23Type II lissencephaly (HP:0007260)3.16671395
24Pancreatic fibrosis (HP:0100732)3.13358430
25Panhypogammaglobulinemia (HP:0003139)3.11956027
26IgG deficiency (HP:0004315)3.07739885
27Molar tooth sign on MRI (HP:0002419)3.04844876
28Abnormality of midbrain morphology (HP:0002418)3.04844876
29Optic neuritis (HP:0100653)3.03643046
30Retrobulbar optic neuritis (HP:0100654)3.03643046
31Abnormality of macrophages (HP:0004311)3.03136468
32Nephronophthisis (HP:0000090)3.00424121
33Petechiae (HP:0000967)2.97360321
34True hermaphroditism (HP:0010459)2.97099380
35Abnormality of aromatic amino acid family metabolism (HP:0004338)2.96826721
36Joint hemorrhage (HP:0005261)2.93202103
37Colitis (HP:0002583)2.91753858
38Xanthomatosis (HP:0000991)2.91514313
39Stomach cancer (HP:0012126)2.89022792
40Abnormal platelet function (HP:0011869)2.85421300
41Impaired platelet aggregation (HP:0003540)2.85421300
42Recurrent fungal infections (HP:0002841)2.79463997
43Meningitis (HP:0001287)2.79183973
44Attenuation of retinal blood vessels (HP:0007843)2.76541286
45Spontaneous hematomas (HP:0007420)2.73853641
46Cellulitis (HP:0100658)2.69575033
47Abnormality of the renal medulla (HP:0100957)2.67241301
48Clumsiness (HP:0002312)2.66897309
49Abnormal rod and cone electroretinograms (HP:0008323)2.66476936
50Encephalitis (HP:0002383)2.66009345
51Autoimmune thrombocytopenia (HP:0001973)2.65930293
52Renal cortical cysts (HP:0000803)2.64565075
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.63698038
54Pendular nystagmus (HP:0012043)2.62762413
55Inflammation of the large intestine (HP:0002037)2.61693358
56Arterial thrombosis (HP:0004420)2.58551077
57Epistaxis (HP:0000421)2.57472324
58Myocardial infarction (HP:0001658)2.56104786
59Amyloidosis (HP:0011034)2.54613810
60Interstitial pulmonary disease (HP:0006530)2.54606164
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54594630
62Gastrointestinal inflammation (HP:0004386)2.52622038
63Gingival bleeding (HP:0000225)2.50640968
64Axonal loss (HP:0003447)2.50540191
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49811311
66Vasculitis (HP:0002633)2.48845050
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.48313323
68Nasal polyposis (HP:0100582)2.46447049
69Prolonged partial thromboplastin time (HP:0003645)2.46052024
70Abnormality of the nasal mucosa (HP:0000433)2.45447401
71Abnormality of the prostate (HP:0008775)2.44775199
72Increased cerebral lipofuscin (HP:0011813)2.44735706
73Agammaglobulinemia (HP:0004432)2.44522537
74Nephritis (HP:0000123)2.44279533
75Dysostosis multiplex (HP:0000943)2.44008144
76Mediastinal lymphadenopathy (HP:0100721)2.42170517
77Severe combined immunodeficiency (HP:0004430)2.39815938
78Keratoconjunctivitis sicca (HP:0001097)2.36696661
79Pustule (HP:0200039)2.36412818
80Fatigue (HP:0012378)2.35077020
81Deep venous thrombosis (HP:0002625)2.33869999
82Hypobetalipoproteinemia (HP:0003563)2.33637910
83Congenital sensorineural hearing impairment (HP:0008527)2.33500371
84Chronic hepatic failure (HP:0100626)2.32798503
85Intrahepatic cholestasis (HP:0001406)2.32742476
86Aplasia/Hypoplasia of the spleen (HP:0010451)2.30057820
87Asplenia (HP:0001746)2.29657265
88Large for gestational age (HP:0001520)2.29380050
89Recurrent bronchitis (HP:0002837)2.28517029
90Prolonged bleeding time (HP:0003010)2.27823706
91Purpura (HP:0000979)2.25742970
92Decreased central vision (HP:0007663)2.25583365
93Congenital, generalized hypertrichosis (HP:0004540)2.25114413
94Cystic liver disease (HP:0006706)2.24187113
95Decreased circulating renin level (HP:0003351)2.23132535
96Abnormality of liposaccharide metabolism (HP:0010968)2.23121931
97Abnormality of glycosphingolipid metabolism (HP:0004343)2.23121931
98Abnormality of glycolipid metabolism (HP:0010969)2.23121931
99Increased corneal curvature (HP:0100692)2.22230214
100Keratoconus (HP:0000563)2.22230214
101Cerebellar dysplasia (HP:0007033)2.20532618
102Periodontitis (HP:0000704)2.20151370
103Abnormality of glutamine family amino acid metabolism (HP:0010902)2.18404643
104Mucopolysacchariduria (HP:0008155)2.17308365
105Urinary glycosaminoglycan excretion (HP:0003541)2.17308365
106Thrombophlebitis (HP:0004418)2.17280814
107Progressive inability to walk (HP:0002505)2.16962926
108Hypoplasia of the pons (HP:0012110)2.16757342
109Abnormality of the common coagulation pathway (HP:0010990)2.16568577
110Genetic anticipation (HP:0003743)2.15837291
111Pulmonary infiltrates (HP:0002113)2.14980838
112Abnormality of the pons (HP:0007361)2.14943165
113Hepatosplenomegaly (HP:0001433)2.14215849
114Gastrointestinal infarctions (HP:0005244)2.14161618
115Abnormality of T cell physiology (HP:0011840)2.13978455
116Osteomyelitis (HP:0002754)2.13701138
117Polydipsia (HP:0001959)2.12177529
118Abnormal drinking behavior (HP:0030082)2.12177529
119Keratoconjunctivitis (HP:0001096)2.11749585
120Inability to walk (HP:0002540)2.11167379
121Abnormality of T cells (HP:0002843)2.10580242
122Methylmalonic aciduria (HP:0012120)2.10545237
123Pulmonary embolism (HP:0002204)2.10439546
124Prostate neoplasm (HP:0100787)2.09140405
125Abnormal delayed hypersensitivity skin test (HP:0002963)2.08248770
126Increased serum ferritin (HP:0003281)2.06597153
127Methylmalonic acidemia (HP:0002912)2.06026638
128Hyperventilation (HP:0002883)2.05350375
129Thoracic kyphosis (HP:0002942)2.04799664
130Reduced antithrombin III activity (HP:0001976)2.04607589
131Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04222339
132Hypercholesterolemia (HP:0003124)2.04101270
133B lymphocytopenia (HP:0010976)2.02845025
134Abnormality of B cell number (HP:0010975)2.02845025
135Ketosis (HP:0001946)2.02840700
136Tubular atrophy (HP:0000092)2.02634413
137Thyroiditis (HP:0100646)2.01996433
138Gaze-evoked nystagmus (HP:0000640)2.00911446
139Abnormality of eosinophils (HP:0001879)2.00755865
140Abnormality of iron homeostasis (HP:0011031)1.99597469
141Recurrent cutaneous fungal infections (HP:0011370)1.98921002
142Chronic mucocutaneous candidiasis (HP:0002728)1.98921002
1433-Methylglutaconic aciduria (HP:0003535)1.97922730
144Abnormality of polysaccharide metabolism (HP:0011012)1.97921238
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97921238
146Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97921238
147Leukocytosis (HP:0001974)1.96772838
148Short 1st metacarpal (HP:0010034)1.96599181
149Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.96599181
150Agitation (HP:0000713)1.96528100
151Abnormal platelet volume (HP:0011876)1.96034079
152Abnormality of alanine metabolism (HP:0010916)1.95907534
153Hyperalaninemia (HP:0003348)1.95907534
154Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95907534
155Chronic obstructive pulmonary disease (HP:0006510)1.95763852
156Obstructive lung disease (HP:0006536)1.95763852
157Gastrointestinal stroma tumor (HP:0100723)1.95353654
158Furrowed tongue (HP:0000221)1.95075793
159Progressive cerebellar ataxia (HP:0002073)1.93081085
160Severe muscular hypotonia (HP:0006829)1.92680177
161Abnormality of T cell number (HP:0011839)1.92160713
162Abnormality of the nasal septum (HP:0000419)1.88796835
163Hypoproteinemia (HP:0003075)1.88632008
164Abnormality of DNA repair (HP:0003254)1.88322933
165Ketoacidosis (HP:0001993)1.86918472
166Dynein arm defect of respiratory motile cilia (HP:0012255)1.86834805
167Absent/shortened dynein arms (HP:0200106)1.86834805
168Bony spicule pigmentary retinopathy (HP:0007737)1.85808040
169Aplasia/Hypoplasia of the tibia (HP:0005772)1.84094039
170Medial flaring of the eyebrow (HP:0010747)1.84043160
171Mitochondrial inheritance (HP:0001427)1.79703545
172Eosinophilia (HP:0001880)1.75412314
173Congenital hepatic fibrosis (HP:0002612)1.73656332
174T lymphocytopenia (HP:0005403)1.73423255
175Abnormality of the 1st metacarpal (HP:0010009)1.73005515
176Abnormality of the renal collecting system (HP:0004742)1.72390702
177Alveolar cell carcinoma (HP:0006519)1.71479965
178Hemiplegia (HP:0002301)1.71146924
179Chorioretinal atrophy (HP:0000533)1.70976868
180Hypoalbuminemia (HP:0003073)1.69166914
181Abnormal albumin level (HP:0012116)1.69166914
182Hematochezia (HP:0002573)1.68883542

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.48437302
2MAP4K14.02452406
3TGFBR23.29032158
4TYK23.21307116
5KIT3.12685802
6TLK13.11598752
7GRK12.86022191
8TEC2.84314500
9MAP3K142.76518673
10TBK12.73553195
11CSF1R2.70464276
12BLK2.64524535
13BTK2.64134546
14FLT32.58409084
15IRAK42.58081800
16ERN12.57779273
17MAP4K22.39737418
18ZAP702.34078973
19NUAK12.11606628
20ZAK2.07345806
21IRAK32.04882382
22BMPR1B2.01501640
23TAOK31.90357546
24IKBKE1.89116703
25PINK11.87340166
26SYK1.81675957
27ITK1.74867244
28IKBKB1.74776124
29JAK31.70935847
30PKN21.70510407
31MAP2K31.64544304
32TXK1.63082555
33STK101.60439186
34INSRR1.58311261
35BCKDK1.54645357
36MAPK131.48319071
37EEF2K1.44941845
38EPHB11.40018962
39PIM21.37213270
40LCK1.34791019
41WNK31.33520415
42WNK41.31211534
43GRK61.29847808
44JAK11.29744717
45HCK1.26811285
46LYN1.25771841
47MUSK1.24551898
48FGFR41.24097527
49FES1.21524768
50NME21.19812034
51MAP2K61.17165056
52LRRK21.15321055
53CLK11.09278546
54CSK1.09043050
55RIPK41.06161247
56ADRBK11.05020859
57MATK1.03527275
58DAPK21.03151178
59OXSR11.01982707
60KDR1.00534483
61PIM10.99285702
62MAP2K20.99285142
63JAK20.98904968
64PTK60.93343965
65MARK30.93006707
66NEK90.90547088
67MAP3K100.88819307
68PHKG10.88689570
69PHKG20.88689570
70GRK70.86073713
71CHUK0.85650722
72PTK2B0.84704138
73MAPK40.79533523
74MAPK110.78374939
75TRPM70.78345999
76ADRBK20.77871325
77TGFBR10.75784715
78CDK60.75660503
79RPS6KA40.74686116
80IRAK10.72660185
81CAMK1D0.71228780
82PAK30.69306791
83STK110.68343941
84PIK3CG0.67866437
85GRK50.67228358
86PAK40.66940741
87STK390.63890653
88PRKG20.63387062
89FGFR20.62599242
90NME10.62516029
91CDK40.62383752
92CAMKK10.61837032
93STK40.61514188
94RPS6KA50.60512062
95MAP3K130.60350036
96TIE10.58230890
97PRKCE0.57019445
98EPHA30.56151104
99HIPK20.55041398
100MAP3K40.54214228
101MAPK120.53839605
102VRK10.53608092
103CCNB10.53089214
104SIK20.52160746
105PRKD20.51816180
106ABL10.51528403
107TRIB30.51002884
108PRKCI0.48572766
109MAP3K30.48026525
110PIK3CA0.47415866
111PRKCQ0.47264301
112PLK20.46884733
113DYRK20.46293971
114MST40.46188078
115MAP3K110.46109155
116PASK0.46048678
117PRKCG0.45758195
118RPS6KA60.45683877
119MAPKAPK20.45415524
120FGFR30.45029860
121MAPKAPK50.44941437
122EIF2AK20.44467013
123EGFR0.43834603
124CSNK1G20.43031740
125MAPKAPK30.42275150
126NLK0.41653742
127CSNK1G30.41104828
128PRKCH0.39259656
129PRKACA0.38740118
130MAP2K10.38579675
131MAPK150.38520735
132CASK0.37297522
133IGF1R0.37068092
134CSNK1A10.37035190
135SIK10.36780615
136PDK10.36688703
137NEK20.36668195
138PRKCD0.35795032
139MAP3K80.34785021
140PRKCZ0.34428813
141MAP3K70.34136420
142MAPK30.33791809
143RPS6KB20.33371399
144MOS0.32938527
145RPS6KL10.32758588
146RPS6KC10.32758588
147PRKAA20.28879471
148TNIK0.28191900
149DYRK1B0.28162008
150TNK20.28155378
151CAMKK20.27597455
152ACVR1B0.25406329

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.45923636
2Caffeine metabolism_Homo sapiens_hsa002322.71067378
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.47000464
4Linoleic acid metabolism_Homo sapiens_hsa005912.38456743
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.37988350
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.33731909
7Autoimmune thyroid disease_Homo sapiens_hsa053202.30847257
8Primary immunodeficiency_Homo sapiens_hsa053402.27618467
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.25938435
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.24656563
11Phototransduction_Homo sapiens_hsa047442.22404876
12Leishmaniasis_Homo sapiens_hsa051402.21474159
13Type I diabetes mellitus_Homo sapiens_hsa049402.19661405
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16169636
15Complement and coagulation cascades_Homo sapiens_hsa046102.14740104
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05326137
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.00836335
18Other glycan degradation_Homo sapiens_hsa005111.92485109
19B cell receptor signaling pathway_Homo sapiens_hsa046621.89800909
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.83863339
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.81808136
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.73443481
23Osteoclast differentiation_Homo sapiens_hsa043801.72604281
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71860214
25Pertussis_Homo sapiens_hsa051331.71008627
26Folate biosynthesis_Homo sapiens_hsa007901.67285320
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63280975
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57113004
29Tryptophan metabolism_Homo sapiens_hsa003801.54316175
30Ether lipid metabolism_Homo sapiens_hsa005651.50304991
31Antigen processing and presentation_Homo sapiens_hsa046121.47549196
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46527605
33Butanoate metabolism_Homo sapiens_hsa006501.43110814
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38903197
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38597212
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.37972737
37Fatty acid degradation_Homo sapiens_hsa000711.37384248
38Peroxisome_Homo sapiens_hsa041461.37172471
39Measles_Homo sapiens_hsa051621.35965627
40Histidine metabolism_Homo sapiens_hsa003401.34899905
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33725276
42Vitamin digestion and absorption_Homo sapiens_hsa049771.33205767
43Nitrogen metabolism_Homo sapiens_hsa009101.29331247
44Homologous recombination_Homo sapiens_hsa034401.27830949
45Legionellosis_Homo sapiens_hsa051341.26536001
46Glycerolipid metabolism_Homo sapiens_hsa005611.26440837
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24452135
48Lysosome_Homo sapiens_hsa041421.24337637
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22364481
50Fat digestion and absorption_Homo sapiens_hsa049751.21808590
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20723159
52Arachidonic acid metabolism_Homo sapiens_hsa005901.18063002
53Hematopoietic cell lineage_Homo sapiens_hsa046401.15959302
54Arginine biosynthesis_Homo sapiens_hsa002201.15647373
55Morphine addiction_Homo sapiens_hsa050321.14255147
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14230033
57ABC transporters_Homo sapiens_hsa020101.10491834
58Allograft rejection_Homo sapiens_hsa053301.10077114
59Chemical carcinogenesis_Homo sapiens_hsa052041.09000923
60Regulation of autophagy_Homo sapiens_hsa041401.08364682
61Nicotine addiction_Homo sapiens_hsa050331.06567702
62Starch and sucrose metabolism_Homo sapiens_hsa005001.06106610
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05827761
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05388279
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04872947
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03731883
67Tuberculosis_Homo sapiens_hsa051521.03702612
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02425508
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01896004
70Selenocompound metabolism_Homo sapiens_hsa004501.01842144
71Toxoplasmosis_Homo sapiens_hsa051451.01131859
72Pentose phosphate pathway_Homo sapiens_hsa000301.01119659
73Malaria_Homo sapiens_hsa051441.00138977
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00125421
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99117577
76Olfactory transduction_Homo sapiens_hsa047400.98948626
77beta-Alanine metabolism_Homo sapiens_hsa004100.98399681
78PPAR signaling pathway_Homo sapiens_hsa033200.98368725
79Herpes simplex infection_Homo sapiens_hsa051680.98122869
80Rheumatoid arthritis_Homo sapiens_hsa053230.97572414
81Taste transduction_Homo sapiens_hsa047420.94301484
82Retinol metabolism_Homo sapiens_hsa008300.93812340
83Influenza A_Homo sapiens_hsa051640.92587381
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92018286
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91426439
86Oxidative phosphorylation_Homo sapiens_hsa001900.88578874
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.85703322
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85626061
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85473719
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85076950
91RNA degradation_Homo sapiens_hsa030180.83833549
92RNA polymerase_Homo sapiens_hsa030200.82657492
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.82526546
94Shigellosis_Homo sapiens_hsa051310.80188229
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80186944
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.79955404
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.79334154
98Apoptosis_Homo sapiens_hsa042100.78869802
99Fatty acid metabolism_Homo sapiens_hsa012120.78837664
100Sulfur relay system_Homo sapiens_hsa041220.78291142
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77684957
102Insulin secretion_Homo sapiens_hsa049110.77285782
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76852885
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76254322
105Serotonergic synapse_Homo sapiens_hsa047260.72108914
106Fatty acid elongation_Homo sapiens_hsa000620.71877805
107Galactose metabolism_Homo sapiens_hsa000520.71677142
108Renin-angiotensin system_Homo sapiens_hsa046140.70784145
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70516968
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.68624246
111Circadian entrainment_Homo sapiens_hsa047130.68302959
112Ovarian steroidogenesis_Homo sapiens_hsa049130.67707074
113Salivary secretion_Homo sapiens_hsa049700.66185766
114Graft-versus-host disease_Homo sapiens_hsa053320.65157627
115Fanconi anemia pathway_Homo sapiens_hsa034600.64155031
116Calcium signaling pathway_Homo sapiens_hsa040200.62763436
117Salmonella infection_Homo sapiens_hsa051320.62184450
118Hepatitis B_Homo sapiens_hsa051610.61894932
119T cell receptor signaling pathway_Homo sapiens_hsa046600.61622291
120DNA replication_Homo sapiens_hsa030300.61388953
121Acute myeloid leukemia_Homo sapiens_hsa052210.59760387
122Systemic lupus erythematosus_Homo sapiens_hsa053220.58216742
123Asthma_Homo sapiens_hsa053100.57960886
124Chemokine signaling pathway_Homo sapiens_hsa040620.57480741
125Collecting duct acid secretion_Homo sapiens_hsa049660.56244259
126Hepatitis C_Homo sapiens_hsa051600.55886998
127Basal transcription factors_Homo sapiens_hsa030220.55752862
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54179395
129Ribosome_Homo sapiens_hsa030100.53914728
130Glutathione metabolism_Homo sapiens_hsa004800.53792930
131Dorso-ventral axis formation_Homo sapiens_hsa043200.53727652
132Platelet activation_Homo sapiens_hsa046110.53302455
133Parkinsons disease_Homo sapiens_hsa050120.50769421
134Base excision repair_Homo sapiens_hsa034100.50220895
135Bile secretion_Homo sapiens_hsa049760.48673156
136TNF signaling pathway_Homo sapiens_hsa046680.48081790
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48069064
138One carbon pool by folate_Homo sapiens_hsa006700.45727229
139African trypanosomiasis_Homo sapiens_hsa051430.44566052
140Steroid biosynthesis_Homo sapiens_hsa001000.44116022
141Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43951740
142Sulfur metabolism_Homo sapiens_hsa009200.43616008
143Glutamatergic synapse_Homo sapiens_hsa047240.42158784
144Viral myocarditis_Homo sapiens_hsa054160.41126093
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.40685868
146GABAergic synapse_Homo sapiens_hsa047270.40576047
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.40556604
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39643224
149Renin secretion_Homo sapiens_hsa049240.36783247
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33018345
151Type II diabetes mellitus_Homo sapiens_hsa049300.32484040

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