SLC25A46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial solute carrier protein family member. It functions in promoting mitochondrial fission, and prevents the formation of hyperfilamentous mitochondria. Mutation of this gene results in neuropathy and optic atrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPII vesicle coating (GO:0048208)5.15067855
2synaptic vesicle maturation (GO:0016188)4.54716986
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.36855821
4synaptic vesicle exocytosis (GO:0016079)4.35615152
5glutamate secretion (GO:0014047)4.22227599
6regulation of synaptic vesicle exocytosis (GO:2000300)4.20958123
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.99046712
8regulation of relaxation of muscle (GO:1901077)3.89444845
9locomotory exploration behavior (GO:0035641)3.89100973
10regulation of synaptic vesicle transport (GO:1902803)3.76764744
11neuronal action potential propagation (GO:0019227)3.70254590
12negative regulation of thymocyte apoptotic process (GO:0070244)3.58581927
13response to pheromone (GO:0019236)3.56696828
14protein localization to synapse (GO:0035418)3.51648329
15response to hydroperoxide (GO:0033194)3.49489057
16regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.48176612
17neurotransmitter secretion (GO:0007269)3.45652155
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.42572001
19cellular potassium ion homeostasis (GO:0030007)3.40692258
20positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.38658945
21positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36964635
22activation of protein kinase A activity (GO:0034199)3.36854036
23neuron cell-cell adhesion (GO:0007158)3.36446467
24vocalization behavior (GO:0071625)3.35808595
25exploration behavior (GO:0035640)3.28550190
26proline transport (GO:0015824)3.28016587
27synaptic vesicle docking involved in exocytosis (GO:0016081)3.27458332
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.24793678
29regulation of glutamate receptor signaling pathway (GO:1900449)3.23682918
30vesicle transport along microtubule (GO:0047496)3.21799653
31vesicle coating (GO:0006901)3.16673460
32detection of calcium ion (GO:0005513)3.16471163
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.16165376
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.15605485
35nerve growth factor signaling pathway (GO:0038180)3.12714397
36cellular response to ethanol (GO:0071361)3.07574435
37regulation of synapse structural plasticity (GO:0051823)3.06241891
38regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.03806841
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01223428
40regulation of neuronal synaptic plasticity (GO:0048168)3.01109310
41interkinetic nuclear migration (GO:0022027)3.00892845
42negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.00523234
43beta-amyloid metabolic process (GO:0050435)2.99073127
44neuron recognition (GO:0008038)2.97826338
45phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.94811513
46positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.91735627
47glutamate receptor signaling pathway (GO:0007215)2.90844466
48layer formation in cerebral cortex (GO:0021819)2.90031345
49negative regulation of neurotransmitter transport (GO:0051589)2.89459041
50regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.88460216
51succinate metabolic process (GO:0006105)2.88216316
52carnitine shuttle (GO:0006853)2.87776719
53Golgi to endosome transport (GO:0006895)2.87688286
54ionotropic glutamate receptor signaling pathway (GO:0035235)2.86884076
55dopamine biosynthetic process (GO:0042416)2.86426389
56neurotransmitter transport (GO:0006836)2.84863764
57negative regulation of neurotransmitter secretion (GO:0046929)2.84153641
58regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.83913665
59organelle transport along microtubule (GO:0072384)2.83910278
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82948027
61endoplasmic reticulum organization (GO:0007029)2.82893302
62membrane budding (GO:0006900)2.82612010
63gamma-aminobutyric acid signaling pathway (GO:0007214)2.82206207
64actin-myosin filament sliding (GO:0033275)2.81757199
65muscle filament sliding (GO:0030049)2.81757199
66regulation of actin filament-based movement (GO:1903115)2.81538566
67positive regulation of glycolytic process (GO:0045821)2.81297762
68negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80635345
69gamma-aminobutyric acid transport (GO:0015812)2.79361011
70neurotransmitter-gated ion channel clustering (GO:0072578)2.78290896
71membrane depolarization during action potential (GO:0086010)2.78283771
72positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.77452494
73positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.77452494
74positive regulation of mitotic sister chromatid separation (GO:1901970)2.77452494
75interleukin-6-mediated signaling pathway (GO:0070102)2.76567103
76Golgi to plasma membrane protein transport (GO:0043001)2.76260490
77fatty acid homeostasis (GO:0055089)2.76161107
78regulation of cAMP-dependent protein kinase activity (GO:2000479)2.75486643
79neuron-neuron synaptic transmission (GO:0007270)2.75040808
80positive regulation of potassium ion transmembrane transport (GO:1901381)2.75026264
81regulation of cell communication by electrical coupling (GO:0010649)2.74913686
82negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.73185667
83COPI coating of Golgi vesicle (GO:0048205)2.71844540
84Golgi transport vesicle coating (GO:0048200)2.71844540
85cellular ketone body metabolic process (GO:0046950)2.70658912
86tricarboxylic acid cycle (GO:0006099)2.70041285
87regulation of neurotransmitter levels (GO:0001505)2.68795428
88ether lipid metabolic process (GO:0046485)2.67465791
89regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.67282407
90calcium ion-dependent exocytosis (GO:0017156)2.67141499
91regulation of acyl-CoA biosynthetic process (GO:0050812)2.66553821
92actin-mediated cell contraction (GO:0070252)2.66540321
93regulation of amyloid precursor protein catabolic process (GO:1902991)2.66377622
94cell communication by electrical coupling (GO:0010644)2.66041812
95negative regulation of dendrite morphogenesis (GO:0050774)2.65960224
96lipid particle organization (GO:0034389)2.65874896
97negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.64913105
98microtubule nucleation (GO:0007020)2.64040593
99righting reflex (GO:0060013)2.64022536
100sarcoplasmic reticulum calcium ion transport (GO:0070296)2.63795035
101negative regulation of cytosolic calcium ion concentration (GO:0051481)2.63257722
102regulation of Golgi to plasma membrane protein transport (GO:0042996)2.63035505
103long-term synaptic potentiation (GO:0060291)2.62799299
104regulation of glucokinase activity (GO:0033131)2.62397663
105regulation of hexokinase activity (GO:1903299)2.62397663
106regulation of clathrin-mediated endocytosis (GO:2000369)2.62233514
107regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.61983231
108positive regulation of cardiac muscle hypertrophy (GO:0010613)2.61792554
109positive regulation of muscle hypertrophy (GO:0014742)2.61792554
110regulation of neurotransmitter secretion (GO:0046928)2.61546952
111vesicle docking (GO:0048278)2.61396765
112ketone body metabolic process (GO:1902224)2.58336050
113regulation of excitatory postsynaptic membrane potential (GO:0060079)2.57804106
114regulation of dendritic spine morphogenesis (GO:0061001)2.56764281
115protein targeting to Golgi (GO:0000042)2.56718191
116positive regulation of dendritic spine morphogenesis (GO:0061003)2.55628514
117synaptic transmission, glutamatergic (GO:0035249)2.55507421
118positive regulation of potassium ion transport (GO:0043268)2.55018174
119inositol phosphate catabolic process (GO:0071545)2.54739305
120long term synaptic depression (GO:0060292)2.54530755
121regulation of vesicle fusion (GO:0031338)2.54429756
122signal peptide processing (GO:0006465)2.53997529
123positive regulation of dendritic spine development (GO:0060999)2.53567306
124G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.53463774
125regulation of coenzyme metabolic process (GO:0051196)2.53038523
126regulation of cofactor metabolic process (GO:0051193)2.53038523
127axonal fasciculation (GO:0007413)2.52304393
128regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.52197566
129regulation of synaptic plasticity (GO:0048167)2.51640546
130synaptic vesicle endocytosis (GO:0048488)2.50171900
131protein targeting to lysosome (GO:0006622)2.49914361
132establishment of protein localization to vacuole (GO:0072666)2.49914361
133protein targeting to vacuole (GO:0006623)2.49914361
134positive regulation of protein autophosphorylation (GO:0031954)2.49449216
135regulation of synaptic transmission, glutamatergic (GO:0051966)2.48775137
136regulation of calcium ion transmembrane transport (GO:1903169)2.48680441
137regulation of calcium ion transmembrane transporter activity (GO:1901019)2.48680441
138negative regulation of dendrite development (GO:2000171)2.48645234
139alanine transport (GO:0032328)2.48494983
140short-chain fatty acid metabolic process (GO:0046459)2.48029732
141regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.47980131
142labyrinthine layer development (GO:0060711)2.47186332
143regulation of cardiac muscle cell contraction (GO:0086004)2.47037310
144mRNA modification (GO:0016556)2.46175113
145regulation of postsynaptic membrane potential (GO:0060078)2.45709982
146synaptic vesicle transport (GO:0048489)2.45593151
147establishment of synaptic vesicle localization (GO:0097480)2.45593151
148establishment of vesicle localization (GO:0051650)2.45574708
149sodium ion export (GO:0071436)2.45558128
150glycogen catabolic process (GO:0005980)2.45126010
151transmission of nerve impulse (GO:0019226)2.45018375
152regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.44558388
153calcium-mediated signaling using intracellular calcium source (GO:0035584)2.44405686
154presynaptic membrane assembly (GO:0097105)2.43745410
155retrograde transport, vesicle recycling within Golgi (GO:0000301)2.42412907
156carnitine transport (GO:0015879)2.42403200
157amino-acid betaine transport (GO:0015838)2.42403200
158relaxation of cardiac muscle (GO:0055119)2.42164796
159urinary tract smooth muscle contraction (GO:0014848)2.42011672
160establishment of protein localization to Golgi (GO:0072600)2.41866598
161regulation of Rac protein signal transduction (GO:0035020)2.41477020
162regulation of dendritic spine development (GO:0060998)2.39864097
163axon cargo transport (GO:0008088)2.39507241
164negative regulation of protein localization to plasma membrane (GO:1903077)2.39463970
165inositol phosphate dephosphorylation (GO:0046855)2.39175677
166phosphorylated carbohydrate dephosphorylation (GO:0046838)2.39175677
167fatty acid transmembrane transport (GO:1902001)2.38461607
168regulation of voltage-gated calcium channel activity (GO:1901385)2.38061228
169innervation (GO:0060384)2.37963615
170potassium ion import (GO:0010107)2.37425389
171nucleus localization (GO:0051647)2.36430459
172cardiac muscle hypertrophy (GO:0003300)2.35743992
173membrane depolarization (GO:0051899)2.35438647
174poly(A)+ mRNA export from nucleus (GO:0016973)2.31440237
175prepulse inhibition (GO:0060134)2.30915331
176glucan catabolic process (GO:0009251)2.30657840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.56978719
2GBX2_23144817_ChIP-Seq_PC3_Human3.67084421
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.68990220
4TAF15_26573619_Chip-Seq_HEK293_Human2.66668917
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59181811
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51933769
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.37581098
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30447928
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26041149
10REST_21632747_ChIP-Seq_MESCs_Mouse2.21680473
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11724152
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09313310
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08577286
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06884424
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05205912
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04073543
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01943073
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01943073
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97548690
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95916636
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94635302
22IGF1R_20145208_ChIP-Seq_DFB_Human1.93869473
23P300_19829295_ChIP-Seq_ESCs_Human1.92765714
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90500944
25* SMAD4_21799915_ChIP-Seq_A2780_Human1.88419869
26EZH2_27294783_Chip-Seq_NPCs_Mouse1.87371111
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83161035
28NR3C1_23031785_ChIP-Seq_PC12_Mouse1.82035158
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80530169
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77612100
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76480181
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.74512493
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74327674
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.74090583
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.73939200
36ZNF274_21170338_ChIP-Seq_K562_Hela1.71580987
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71058941
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70588699
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.70383680
40CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.69994736
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69861258
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69555436
43TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.68308146
44AR_21572438_ChIP-Seq_LNCaP_Human1.67924985
45GATA1_22025678_ChIP-Seq_K562_Human1.67226494
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66331239
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.65345827
48DROSHA_22980978_ChIP-Seq_HELA_Human1.64963749
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62472540
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.62239326
51* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.62190646
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59432278
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56712478
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.56090756
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55437862
56EWS_26573619_Chip-Seq_HEK293_Human1.54243005
57AR_25329375_ChIP-Seq_VCAP_Human1.52672507
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52130653
59OCT4_21477851_ChIP-Seq_ESCs_Mouse1.51910599
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.51529067
61* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49220105
62SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.48548939
63TP53_16413492_ChIP-PET_HCT116_Human1.47298930
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47079989
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45408991
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45159349
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.45123801
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42572942
69FUS_26573619_Chip-Seq_HEK293_Human1.42243368
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.41120063
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39131452
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.38134321
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.38078098
74* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37866598
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37821042
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37104404
77STAT3_23295773_ChIP-Seq_U87_Human1.35822596
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35244799
79SOX2_18555785_Chip-Seq_ESCs_Mouse1.34954399
80P300_18555785_Chip-Seq_ESCs_Mouse1.34233999
81VDR_22108803_ChIP-Seq_LS180_Human1.33150623
82OCT4_18555785_Chip-Seq_ESCs_Mouse1.30801125
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.30060245
84EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29265084
85ER_23166858_ChIP-Seq_MCF-7_Human1.28102899
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27518230
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.25617136
88* BRD4_25478319_ChIP-Seq_HGPS_Human1.25407247
89CBP_20019798_ChIP-Seq_JUKART_Human1.24210758
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24210758
91NMYC_18555785_Chip-Seq_ESCs_Mouse1.24175763
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23631428
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22925868
94BCAT_22108803_ChIP-Seq_LS180_Human1.22540362
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21896237
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21413474
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.20367106
98TCF4_18268006_ChIP-ChIP_LS174T_Human1.20328748
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.20098691
100* TCF4_23295773_ChIP-Seq_U87_Human1.18882006
101CTCF_18555785_Chip-Seq_ESCs_Mouse1.18287613
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18051300
103NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18051300
104* CJUN_26792858_Chip-Seq_BT549_Human1.16544389
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15037397
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.14903980
107SALL4_22934838_ChIP-ChIP_CD34+_Human1.14126763
108RUNX2_22187159_ChIP-Seq_PCA_Human1.13858287
109JUN_21703547_ChIP-Seq_K562_Human1.13332098
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12806196
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.12682319
112CDX2_22108803_ChIP-Seq_LS180_Human1.11007483
113PU1_27457419_Chip-Seq_LIVER_Mouse1.09131099
114EP300_21415370_ChIP-Seq_HL-1_Mouse1.09062988
115KDM2B_26808549_Chip-Seq_REH_Human1.08837512
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08681358
117SMAD1_18555785_Chip-Seq_ESCs_Mouse1.08384646
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08338443
119RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08130219
120ZFX_18555785_Chip-Seq_ESCs_Mouse1.08026207
121ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07348898
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07099614
123PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07062384
124WT1_19549856_ChIP-ChIP_CCG9911_Human1.05508588
125P53_22387025_ChIP-Seq_ESCs_Mouse1.04269108
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03963281
127TP53_18474530_ChIP-ChIP_U2OS_Human1.03653158
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03567657
129BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02878014
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02571080
131YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00847140
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99495193
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99382938
134* AR_19668381_ChIP-Seq_PC3_Human0.98836997
135PRDM14_20953172_ChIP-Seq_ESCs_Human0.97801838
136KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97345148
137CMYC_18555785_Chip-Seq_ESCs_Mouse0.97218491
138HTT_18923047_ChIP-ChIP_STHdh_Human0.96983178
139TCF4_22108803_ChIP-Seq_LS180_Human0.96792079
140RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96631215
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.95527292
142IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93312873
143TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93061358
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91872248
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.91787407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.45145939
2MP0003880_abnormal_central_pattern4.30658900
3MP0010234_abnormal_vibrissa_follicle4.00686266
4MP0003635_abnormal_synaptic_transmissio3.13924383
5MP0005187_abnormal_penis_morphology3.10287434
6MP0004270_analgesia3.06792703
7MP0002009_preneoplasia2.94045434
8MP0001968_abnormal_touch/_nociception2.86997641
9MP0009745_abnormal_behavioral_response2.62588863
10MP0006276_abnormal_autonomic_nervous2.57143295
11MP0009046_muscle_twitch2.56466673
12MP0008057_abnormal_DNA_replication2.55300956
13MP0002735_abnormal_chemical_nociception2.54696200
14MP0005451_abnormal_body_composition2.47680466
15MP0000569_abnormal_digit_pigmentation2.47624712
16MP0002064_seizures2.47521396
17MP0010352_gastrointestinal_tract_polyps2.46394985
18MP0002063_abnormal_learning/memory/cond2.44013098
19MP0002877_abnormal_melanocyte_morpholog2.41899209
20MP0002909_abnormal_adrenal_gland2.32495473
21MP0002736_abnormal_nociception_after2.27064374
22MP0002837_dystrophic_cardiac_calcinosis2.27057662
23MP0002734_abnormal_mechanical_nocicepti2.22306172
24MP0002272_abnormal_nervous_system2.17903067
25MP0003329_amyloid_beta_deposits2.10012308
26MP0002572_abnormal_emotion/affect_behav2.08054637
27MP0009780_abnormal_chondrocyte_physiolo2.02876702
28MP0005423_abnormal_somatic_nervous1.99487188
29MP0000372_irregular_coat_pigmentation1.97733225
30MP0005646_abnormal_pituitary_gland1.91890494
31MP0002733_abnormal_thermal_nociception1.91550876
32MP0001486_abnormal_startle_reflex1.87536997
33MP0000013_abnormal_adipose_tissue1.80278810
34MP0002139_abnormal_hepatobiliary_system1.78731032
35MP0008438_abnormal_cutaneous_collagen1.77571844
36MP0001984_abnormal_olfaction1.77085138
37MP0001501_abnormal_sleep_pattern1.75190759
38MP0002067_abnormal_sensory_capabilities1.73496748
39MP0002269_muscular_atrophy1.73019572
40MP0002166_altered_tumor_susceptibility1.72119662
41MP0004145_abnormal_muscle_electrophysio1.69138510
42MP0005386_behavior/neurological_phenoty1.68076547
43MP0004924_abnormal_behavior1.68076547
44MP0001440_abnormal_grooming_behavior1.66773646
45MP0001970_abnormal_pain_threshold1.65366555
46MP0003633_abnormal_nervous_system1.61947312
47MP0002095_abnormal_skin_pigmentation1.61234485
48MP0005645_abnormal_hypothalamus_physiol1.59885732
49MP0002822_catalepsy1.58138424
50MP0005535_abnormal_body_temperature1.55785502
51MP0004215_abnormal_myocardial_fiber1.54952678
52MP0008569_lethality_at_weaning1.52167985
53MP0001879_abnormal_lymphatic_vessel1.47382993
54MP0003122_maternal_imprinting1.45116487
55MP0004130_abnormal_muscle_cell1.44418437
56MP0000751_myopathy1.42077830
57MP0002184_abnormal_innervation1.41476694
58MP0000759_abnormal_skeletal_muscle1.40879902
59MP0004043_abnormal_pH_regulation1.40595511
60MP0005365_abnormal_bile_salt1.39782504
61MP0002557_abnormal_social/conspecific_i1.38714069
62MP0004134_abnormal_chest_morphology1.36601718
63MP0004811_abnormal_neuron_physiology1.35356271
64MP0003787_abnormal_imprinting1.34524131
65MP0000604_amyloidosis1.31842574
66MP0001502_abnormal_circadian_rhythm1.29992003
67MP0003195_calcinosis1.29760779
68MP0005085_abnormal_gallbladder_physiolo1.27740659
69MP0002971_abnormal_brown_adipose1.26934031
70MP0000015_abnormal_ear_pigmentation1.26258542
71MP0004858_abnormal_nervous_system1.25116903
72MP0000003_abnormal_adipose_tissue1.22868595
73MP0000462_abnormal_digestive_system1.22736091
74MP0001661_extended_life_span1.22645629
75MP0000955_abnormal_spinal_cord1.22227741
76MP0004142_abnormal_muscle_tone1.21833631
77MP0002876_abnormal_thyroid_physiology1.21683055
78MP0000427_abnormal_hair_cycle1.21360124
79MP0003631_nervous_system_phenotype1.21061722
80MP0000778_abnormal_nervous_system1.20931978
81MP0006054_spinal_hemorrhage1.20390965
82MP0002106_abnormal_muscle_physiology1.19724001
83MP0003252_abnormal_bile_duct1.18887888
84MP0002332_abnormal_exercise_endurance1.18858407
85MP0010386_abnormal_urinary_bladder1.17532487
86MP0009697_abnormal_copulation1.17472313
87MP0004036_abnormal_muscle_relaxation1.16138606
88MP0003690_abnormal_glial_cell1.14329257
89MP0002066_abnormal_motor_capabilities/c1.13979134
90MP0003091_abnormal_cell_migration1.12555016
91MP0006138_congestive_heart_failure1.09574999
92MP0006036_abnormal_mitochondrial_physio1.08597292
93MP0004484_altered_response_of1.07856676
94MP0004087_abnormal_muscle_fiber1.07724137
95MP0001529_abnormal_vocalization1.07029618
96MP0003183_abnormal_peptide_metabolism1.06744617
97MP0002229_neurodegeneration1.05381099
98MP0008875_abnormal_xenobiotic_pharmacok1.04436958
99MP0002006_tumorigenesis1.03959962
100MP0003868_abnormal_feces_composition1.03341482
101MP0005379_endocrine/exocrine_gland_phen1.02284962
102MP0001905_abnormal_dopamine_level1.01514577
103MP0002882_abnormal_neuron_morphology1.01179684
104MP0000747_muscle_weakness1.00232907
105MP0004085_abnormal_heartbeat0.98716106
106MP0005253_abnormal_eye_physiology0.98363404
107MP0003632_abnormal_nervous_system0.97907037
108MP0003221_abnormal_cardiomyocyte_apopto0.95504836
109MP0000733_abnormal_muscle_development0.95424898
110MP0002090_abnormal_vision0.94658525
111MP0006035_abnormal_mitochondrial_morpho0.94363871
112MP0005551_abnormal_eye_electrophysiolog0.93104975
113MP0000647_abnormal_sebaceous_gland0.93017135
114MP0003879_abnormal_hair_cell0.91823096
115MP0002078_abnormal_glucose_homeostasis0.91513951
116MP0005369_muscle_phenotype0.91222722
117MP0002396_abnormal_hematopoietic_system0.91091631
118MP0010368_abnormal_lymphatic_system0.90278839
119MP0002638_abnormal_pupillary_reflex0.89993968
120MP0005332_abnormal_amino_acid0.89933392
121MP0010678_abnormal_skin_adnexa0.89734883
122MP0008874_decreased_physiological_sensi0.89185561
123MP0010094_abnormal_chromosome_stability0.89175181
124MP0005330_cardiomyopathy0.89131647
125MP0001177_atelectasis0.87813332
126MP0003172_abnormal_lysosome_physiology0.87646164
127MP0000920_abnormal_myelination0.87532285
128MP0005275_abnormal_skin_tensile0.87251547
129MP0005584_abnormal_enzyme/coenzyme_acti0.86793304
130MP0005171_absent_coat_pigmentation0.85059068
131MP0000749_muscle_degeneration0.83798876
132MP0005266_abnormal_metabolism0.82376785
133MP0005620_abnormal_muscle_contractility0.81646838
134MP0001243_abnormal_dermal_layer0.81242240
135MP0002896_abnormal_bone_mineralization0.80591711
136MP0002069_abnormal_eating/drinking_beha0.79964723
137MP0000230_abnormal_systemic_arterial0.78934250
138MP0003283_abnormal_digestive_organ0.78298455
139MP0005360_urolithiasis0.78094124
140MP0004147_increased_porphyrin_level0.77878977
141MP0003137_abnormal_impulse_conducting0.77380969
142MP0010329_abnormal_lipoprotein_level0.77217251
143MP0003646_muscle_fatigue0.75877867
144MP0002972_abnormal_cardiac_muscle0.75855267
145MP0002118_abnormal_lipid_homeostasis0.74689382
146MP0005623_abnormal_meninges_morphology0.74633675
147MP0003656_abnormal_erythrocyte_physiolo0.74405263
148MP0001664_abnormal_digestion0.73751569
149MP0008872_abnormal_physiological_respon0.73378745
150MP0005248_abnormal_Harderian_gland0.72871036
151MP0003045_fibrosis0.71786924
152MP0004084_abnormal_cardiac_muscle0.71570454
153MP0005220_abnormal_exocrine_pancreas0.70305681

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.55523916
2Pheochromocytoma (HP:0002666)4.23030752
3Hypoplasia of the thymus (HP:0000778)4.17039098
4Muscle fiber inclusion bodies (HP:0100299)4.03332660
5B lymphocytopenia (HP:0010976)4.00549897
6Thyroiditis (HP:0100646)3.97609336
7Nemaline bodies (HP:0003798)3.92996494
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.86939293
9Neuroendocrine neoplasm (HP:0100634)3.81068908
10Visual hallucinations (HP:0002367)3.79164341
11Exercise-induced muscle cramps (HP:0003710)3.60991411
12Atonic seizures (HP:0010819)3.54828986
13Epileptic encephalopathy (HP:0200134)3.50864022
14Focal seizures (HP:0007359)3.45940241
15Myokymia (HP:0002411)3.44209215
16Absence seizures (HP:0002121)3.35545718
17Hyperventilation (HP:0002883)3.33809134
18Agitation (HP:0000713)3.31282113
19Severe combined immunodeficiency (HP:0004430)3.30506221
20Papillary thyroid carcinoma (HP:0002895)3.28818895
21Abnormality of B cell number (HP:0010975)3.28059036
22Type 1 muscle fiber predominance (HP:0003803)3.26970966
23Abnormality of the left ventricular outflow tract (HP:0011103)3.17913861
24Subaortic stenosis (HP:0001682)3.17913861
25Truncal ataxia (HP:0002078)3.17141257
26Febrile seizures (HP:0002373)3.07727239
27Ketoacidosis (HP:0001993)3.07619172
28Papilledema (HP:0001085)3.06668728
29Bundle branch block (HP:0011710)3.03074240
30Long clavicles (HP:0000890)3.02237249
31Progressive cerebellar ataxia (HP:0002073)3.02189234
32Generalized tonic-clonic seizures (HP:0002069)2.99967654
33Calf muscle hypertrophy (HP:0008981)2.93416050
34Dialeptic seizures (HP:0011146)2.91792409
35Poor eye contact (HP:0000817)2.91116806
36Anxiety (HP:0000739)2.86880812
37Muscle hypertrophy of the lower extremities (HP:0008968)2.85436821
38Action tremor (HP:0002345)2.82330257
39Distal arthrogryposis (HP:0005684)2.81571803
40Hypoglycemic coma (HP:0001325)2.79195504
41Frequent falls (HP:0002359)2.76103122
42Hypoproteinemia (HP:0003075)2.75705053
43Rhabdomyolysis (HP:0003201)2.69898455
44Combined immunodeficiency (HP:0005387)2.67161069
45Abnormal social behavior (HP:0012433)2.62281569
46Impaired social interactions (HP:0000735)2.62281569
47Panhypogammaglobulinemia (HP:0003139)2.61113116
48Scanning speech (HP:0002168)2.60064607
49Depression (HP:0000716)2.57063685
50Thyroid carcinoma (HP:0002890)2.54593946
51Supranuclear gaze palsy (HP:0000605)2.51990391
52T lymphocytopenia (HP:0005403)2.51392923
53Ketosis (HP:0001946)2.50224900
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49318904
55Abnormality of alanine metabolism (HP:0010916)2.49318904
56Hyperalaninemia (HP:0003348)2.49318904
57Abnormality of the calf musculature (HP:0001430)2.48998712
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.47805667
59Hypoglycemic seizures (HP:0002173)2.46398462
60Progressive inability to walk (HP:0002505)2.44328464
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.42845961
62Hyporeflexia of lower limbs (HP:0002600)2.42157140
63EMG: myopathic abnormalities (HP:0003458)2.40767795
64Termporal pattern (HP:0011008)2.40305213
65Insidious onset (HP:0003587)2.40305213
66Broad-based gait (HP:0002136)2.38702827
67Drooling (HP:0002307)2.35630685
68Excessive salivation (HP:0003781)2.35630685
69Amyotrophic lateral sclerosis (HP:0007354)2.34600753
70Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31842751
71Gaze-evoked nystagmus (HP:0000640)2.31320055
72Hyperinsulinemic hypoglycemia (HP:0000825)2.31069878
73Insulin-resistant diabetes mellitus (HP:0000831)2.30179772
74Exercise-induced myalgia (HP:0003738)2.29530875
75Limb dystonia (HP:0002451)2.26220509
76Type II lissencephaly (HP:0007260)2.25620231
77Neurofibrillary tangles (HP:0002185)2.24656748
78Dysdiadochokinesis (HP:0002075)2.24422903
79Retinal dysplasia (HP:0007973)2.24052387
80Difficulty running (HP:0009046)2.21397756
81Rimmed vacuoles (HP:0003805)2.20056599
82Ankle clonus (HP:0011448)2.17407601
83Status epilepticus (HP:0002133)2.17350865
84Symptomatic seizures (HP:0011145)2.16218008
85Abnormality of the hip-girdle musculature (HP:0001445)2.14982085
86Abnormality of the musculature of the pelvis (HP:0001469)2.14982085
87Epileptiform EEG discharges (HP:0011182)2.14907088
88Postural instability (HP:0002172)2.14658288
89Cerebral inclusion bodies (HP:0100314)2.14566511
90Urinary bladder sphincter dysfunction (HP:0002839)2.14196238
91Impaired vibration sensation in the lower limbs (HP:0002166)2.13879002
92Abnormal mitochondria in muscle tissue (HP:0008316)2.13263362
93Fetal akinesia sequence (HP:0001989)2.10097488
94EEG with generalized epileptiform discharges (HP:0011198)2.09283693
95Neoplasm of the peripheral nervous system (HP:0100007)2.09271865
96Inability to walk (HP:0002540)2.08057745
97Acute necrotizing encephalopathy (HP:0006965)2.05221432
98Hyperglycemia (HP:0003074)2.04990741
99Abnormal eating behavior (HP:0100738)2.04662734
100Hypokinesia (HP:0002375)2.03487240
101Bradykinesia (HP:0002067)2.03257128
102Impaired smooth pursuit (HP:0007772)2.02716812
103Blue irides (HP:0000635)2.02569005
104Conjunctival telangiectasia (HP:0000524)2.02411658
105Progressive macrocephaly (HP:0004481)2.01925928
106Dysmetria (HP:0001310)2.01077041
107Myoglobinuria (HP:0002913)2.00918038
108Abnormality of T cell number (HP:0011839)2.00785414
109Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.00344492
110Urinary urgency (HP:0000012)2.00122851
111Cerebral hemorrhage (HP:0001342)1.98634592
112Acute encephalopathy (HP:0006846)1.98585654
113Athetosis (HP:0002305)1.98380519
114Sensorimotor neuropathy (HP:0007141)1.98174163
115Asymmetric septal hypertrophy (HP:0001670)1.97154720
116Abnormality of fatty-acid metabolism (HP:0004359)1.96531190
117Amblyopia (HP:0000646)1.94587989
118Sudden death (HP:0001699)1.91812207
119Poor speech (HP:0002465)1.91512782
120Hypsarrhythmia (HP:0002521)1.91307594
121Failure to thrive in infancy (HP:0001531)1.91099336
122Cutaneous melanoma (HP:0012056)1.91046660
123Fair hair (HP:0002286)1.89952731
124Hepatic necrosis (HP:0002605)1.88069309
125Fatigue (HP:0012378)1.87850951
126Gait imbalance (HP:0002141)1.87401028
127Oligomenorrhea (HP:0000876)1.86881057
128Lower limb muscle weakness (HP:0007340)1.85654852
129Psychosis (HP:0000709)1.84031890
130Tetraparesis (HP:0002273)1.83726372
131Gait ataxia (HP:0002066)1.83563327
132Central scotoma (HP:0000603)1.82826223
133Absent speech (HP:0001344)1.82684380
134Delayed gross motor development (HP:0002194)1.81866628
135Lower limb hyperreflexia (HP:0002395)1.80921830
136Generalized hypopigmentation of hair (HP:0011358)1.80132648
137Diminished movement (HP:0002374)1.79297696
138Polyphagia (HP:0002591)1.78969859
139Abnormal EKG (HP:0003115)1.78678427
140Restlessness (HP:0000711)1.76729753
141Intention tremor (HP:0002080)1.76153704
142Mildly elevated creatine phosphokinase (HP:0008180)1.75965511
143Increased serum pyruvate (HP:0003542)1.74387730
144Rigidity (HP:0002063)1.73866709
145Exotropia (HP:0000577)1.73735353
146Medial flaring of the eyebrow (HP:0010747)1.73413720
147Cerebral edema (HP:0002181)1.73251743
148Hypothermia (HP:0002045)1.72873914
149Abnormality of glycolysis (HP:0004366)1.72371825
150Mutism (HP:0002300)1.72336333
151Dysmetric saccades (HP:0000641)1.71374435
152Syncope (HP:0001279)1.71362160
153Spastic gait (HP:0002064)1.70503067
154Pelvic girdle muscle weakness (HP:0003749)1.69986079
155Abnormality of the lower motor neuron (HP:0002366)1.69284021
156Cystic hygroma (HP:0000476)1.68188516
157Chronic diarrhea (HP:0002028)1.67302524
158Metaphyseal dysplasia (HP:0100255)1.66702390
159Shoulder girdle muscle weakness (HP:0003547)1.65790695
160Proximal amyotrophy (HP:0007126)1.65232892
161Renal cortical cysts (HP:0000803)1.64583570
162Neck muscle weakness (HP:0000467)1.63233499
163Menstrual irregularities (HP:0000858)1.62409717
164Abnormality of skeletal muscle fiber size (HP:0012084)1.60626721
165Atrioventricular block (HP:0001678)1.59394536
166Hyperkalemia (HP:0002153)1.58566260
167Heart block (HP:0012722)1.56952638
168Limb-girdle muscle weakness (HP:0003325)1.56128658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.77498743
2MAP3K93.29980552
3EIF2AK33.26877002
4EPHA42.92438397
5MINK12.92167173
6NEK12.83198142
7MAP3K42.80298197
8MAP2K72.65621435
9CAMKK22.61017862
10NTRK12.54645573
11MAP2K42.34539873
12NEK92.26588382
13MAP3K122.26054308
14TRIM282.23841857
15RIPK42.06761535
16INSRR2.05857109
17MAP3K132.01048360
18ACVR1B1.93882582
19DAPK21.78740335
20MARK11.78085795
21KSR21.77452699
22WNK31.76291053
23LMTK21.75206074
24CASK1.74241855
25PIK3CG1.63731007
26CDK61.55903952
27CAMKK11.54374553
28STK38L1.51646874
29PLK21.51470366
30ARAF1.49284526
31SCYL21.48388878
32PHKG11.46457952
33PHKG21.46457952
34GRK51.45727605
35KSR11.44698230
36PDK41.44387662
37PDK31.44387662
38PAK61.42766029
39TTN1.42752531
40TNIK1.41295712
41PINK11.40887475
42STK241.33812599
43CDK51.28304385
44EPHA31.27806692
45CSNK1G31.23892607
46DAPK11.23058565
47CDK191.22136300
48PAK31.21361077
49MAP3K141.15752238
50CSNK1G11.13684536
51FRK1.13143234
52JAK11.12810571
53GRK71.11827838
54CSNK1A1L1.09832685
55MAP3K21.09413583
56CAMK2A1.06311238
57RPS6KB11.06300841
58FGFR31.04614098
59PRKCG1.04524031
60NTRK21.00873882
61FLT30.96489270
62MUSK0.94935541
63OXSR10.93475318
64MAP4K20.91572030
65SGK2230.91332185
66SGK4940.91332185
67RET0.90285589
68MET0.88481173
69MAPK130.88051188
70CSNK1G20.86433564
71OBSCN0.85908543
72CAMK2D0.84048484
73PTK2B0.83816477
74PRKD30.82723044
75SIK30.82330258
76MAPKAPK50.80851764
77PDK10.80756383
78PRKCE0.80437167
79TRPM70.80163421
80MAPK120.80016466
81CDK30.79866734
82BMPR1B0.79801911
83AKT30.78733746
84UHMK10.77057987
85WNK40.76291751
86LIMK10.76206012
87TIE10.75809739
88CLK10.75451212
89CAMK10.73148286
90FES0.72520524
91STK390.72316722
92STK30.72017779
93PNCK0.71441130
94CDK90.71011549
95LATS10.69450182
96BCKDK0.69035660
97PDPK10.67764413
98CDK140.67661167
99CAMK2B0.65759182
100PRKCH0.65265543
101NEK60.64125925
102EIF2AK10.63795627
103SGK20.63519695
104CCNB10.63087205
105SRPK10.62678124
106FER0.62203999
107MAPK110.61211161
108WNK10.60152185
109ERBB30.60041871
110MAP2K10.59658898
111STK380.58902271
112CAMK2G0.58863676
113SIK20.57133799
114BCR0.57027792
115LATS20.56889668
116BMPR20.56407210
117BRSK20.56264090
118PKN10.55237192
119STK110.54023860
120PRKAA10.52567603
121SGK10.52489164
122CAMK1G0.52337795
123ADRBK10.51398525
124HIPK20.51270913
125EIF2AK20.49645291
126BRSK10.49126869
127RAF10.48659783
128PDGFRA0.48653985
129MAP3K10.48300031
130MAP3K50.47993889
131PRKAA20.47084123
132CDK180.46345283
133PRKCQ0.46187122
134PRKCZ0.45838508
135DYRK1A0.45321604
136PRKACB0.45184638
137MELK0.44431297
138RPS6KA40.43380717
139MAP3K70.42697450
140PRKACA0.41821395
141CDK150.41352065
142JAK20.41025625
143NLK0.39757801
144AKT20.39339119
145SGK30.39303398

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.11212775
2Synaptic vesicle cycle_Homo sapiens_hsa047212.61195017
3Nicotine addiction_Homo sapiens_hsa050332.56866843
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.36160313
5GABAergic synapse_Homo sapiens_hsa047272.15808841
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.14395321
7Long-term potentiation_Homo sapiens_hsa047202.07651682
8Circadian entrainment_Homo sapiens_hsa047132.06843380
9Non-homologous end-joining_Homo sapiens_hsa034502.04109840
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02118405
11Insulin secretion_Homo sapiens_hsa049111.99196181
12Olfactory transduction_Homo sapiens_hsa047401.98213441
13Amphetamine addiction_Homo sapiens_hsa050311.96848959
14Glutamatergic synapse_Homo sapiens_hsa047241.86367783
15Dopaminergic synapse_Homo sapiens_hsa047281.85267063
16Morphine addiction_Homo sapiens_hsa050321.84671058
17Nitrogen metabolism_Homo sapiens_hsa009101.81626131
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.76944570
19Propanoate metabolism_Homo sapiens_hsa006401.72785070
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67161536
21Taste transduction_Homo sapiens_hsa047421.62704485
22Salivary secretion_Homo sapiens_hsa049701.58736916
23Renin secretion_Homo sapiens_hsa049241.55954117
24Gastric acid secretion_Homo sapiens_hsa049711.44704557
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42064577
26Serotonergic synapse_Homo sapiens_hsa047261.39892031
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39845167
28Sulfur metabolism_Homo sapiens_hsa009201.35967091
29Cardiac muscle contraction_Homo sapiens_hsa042601.35326177
30Collecting duct acid secretion_Homo sapiens_hsa049661.35201647
31Cholinergic synapse_Homo sapiens_hsa047251.33177368
32Butanoate metabolism_Homo sapiens_hsa006501.32417904
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27075591
34Fatty acid degradation_Homo sapiens_hsa000711.26733401
35Oxytocin signaling pathway_Homo sapiens_hsa049211.25087211
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22132141
37Cocaine addiction_Homo sapiens_hsa050301.20646164
38Calcium signaling pathway_Homo sapiens_hsa040201.20556006
39Vitamin B6 metabolism_Homo sapiens_hsa007501.18395688
40Long-term depression_Homo sapiens_hsa047301.18043819
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17387273
42Oxidative phosphorylation_Homo sapiens_hsa001901.16659156
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14143141
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13783489
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12089293
46mTOR signaling pathway_Homo sapiens_hsa041501.11900154
47Inositol phosphate metabolism_Homo sapiens_hsa005621.10807403
48FoxO signaling pathway_Homo sapiens_hsa040681.10107864
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07426946
50Vibrio cholerae infection_Homo sapiens_hsa051101.06975933
51Fatty acid metabolism_Homo sapiens_hsa012121.06005337
52Alzheimers disease_Homo sapiens_hsa050101.05726560
53Pyruvate metabolism_Homo sapiens_hsa006201.05016653
54Parkinsons disease_Homo sapiens_hsa050121.04279031
55Glucagon signaling pathway_Homo sapiens_hsa049220.99826722
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99323131
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.98510101
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98066702
59Dorso-ventral axis formation_Homo sapiens_hsa043200.93637433
60Pancreatic secretion_Homo sapiens_hsa049720.93387422
61Peroxisome_Homo sapiens_hsa041460.93002931
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92068652
63Bile secretion_Homo sapiens_hsa049760.91006341
64Type II diabetes mellitus_Homo sapiens_hsa049300.89394826
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88711684
66cAMP signaling pathway_Homo sapiens_hsa040240.86094978
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84584510
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84049163
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83097576
70Arginine biosynthesis_Homo sapiens_hsa002200.82592803
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81261179
72Fatty acid elongation_Homo sapiens_hsa000620.79007774
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78721678
74Gap junction_Homo sapiens_hsa045400.78375900
75Thyroid hormone synthesis_Homo sapiens_hsa049180.78176765
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78158806
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77419787
78GnRH signaling pathway_Homo sapiens_hsa049120.76239855
79Prolactin signaling pathway_Homo sapiens_hsa049170.74685343
80Non-small cell lung cancer_Homo sapiens_hsa052230.72981756
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72555196
82Fatty acid biosynthesis_Homo sapiens_hsa000610.72317184
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.71276855
84Estrogen signaling pathway_Homo sapiens_hsa049150.70423849
85Carbon metabolism_Homo sapiens_hsa012000.69740878
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68708380
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68121107
88PPAR signaling pathway_Homo sapiens_hsa033200.67293192
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.66337595
90Alcoholism_Homo sapiens_hsa050340.66086941
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63022309
92Circadian rhythm_Homo sapiens_hsa047100.61458517
93Renal cell carcinoma_Homo sapiens_hsa052110.60389597
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59052468
95Protein export_Homo sapiens_hsa030600.57918359
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.57732551
97Endometrial cancer_Homo sapiens_hsa052130.56371207
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56180006
99Dilated cardiomyopathy_Homo sapiens_hsa054140.56159050
100Pancreatic cancer_Homo sapiens_hsa052120.55931513
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55773010
102Melanogenesis_Homo sapiens_hsa049160.55299543
103Tryptophan metabolism_Homo sapiens_hsa003800.55210840
104Glioma_Homo sapiens_hsa052140.54630445
105Focal adhesion_Homo sapiens_hsa045100.53247277
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.52464030
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51880216
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51392176
109Insulin signaling pathway_Homo sapiens_hsa049100.50764447
110Starch and sucrose metabolism_Homo sapiens_hsa005000.48833443
111Huntingtons disease_Homo sapiens_hsa050160.48565055
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46926768
113Renin-angiotensin system_Homo sapiens_hsa046140.46874199
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46669560
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45085560
116Oocyte meiosis_Homo sapiens_hsa041140.43493891
117Glycerolipid metabolism_Homo sapiens_hsa005610.43422203
118Regulation of autophagy_Homo sapiens_hsa041400.43167777
119Insulin resistance_Homo sapiens_hsa049310.43095670
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42738336
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41570090
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40864686
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37611466
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36428544
125Prion diseases_Homo sapiens_hsa050200.36236262
126AMPK signaling pathway_Homo sapiens_hsa041520.36129312
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35950908
128Choline metabolism in cancer_Homo sapiens_hsa052310.35401045
129beta-Alanine metabolism_Homo sapiens_hsa004100.34940018

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