SLC25A51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.76980146
2protoporphyrinogen IX metabolic process (GO:0046501)4.92163724
3lysine metabolic process (GO:0006553)4.64831922
4lysine catabolic process (GO:0006554)4.64831922
5short-chain fatty acid metabolic process (GO:0046459)4.60931681
6L-phenylalanine catabolic process (GO:0006559)4.36447694
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.36447694
8fucose catabolic process (GO:0019317)4.30047407
9L-fucose metabolic process (GO:0042354)4.30047407
10L-fucose catabolic process (GO:0042355)4.30047407
11platelet dense granule organization (GO:0060155)4.29559865
12behavioral response to nicotine (GO:0035095)4.29145251
13fatty acid beta-oxidation (GO:0006635)4.26285061
14protoporphyrinogen IX biosynthetic process (GO:0006782)4.24640499
15regulation of sequestering of triglyceride (GO:0010889)4.20661830
16carnitine shuttle (GO:0006853)4.07285864
17fatty acid oxidation (GO:0019395)3.99786614
18fatty acid transmembrane transport (GO:1902001)3.99121230
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.96546220
20L-phenylalanine metabolic process (GO:0006558)3.96546220
21DNA double-strand break processing (GO:0000729)3.94886758
22fatty acid catabolic process (GO:0009062)3.92165307
23lipid oxidation (GO:0034440)3.88748435
24acetyl-CoA metabolic process (GO:0006084)3.85495699
25biotin metabolic process (GO:0006768)3.78930354
26cysteine metabolic process (GO:0006534)3.77513690
27mannosylation (GO:0097502)3.76661876
28tricarboxylic acid metabolic process (GO:0072350)3.75091698
29water-soluble vitamin biosynthetic process (GO:0042364)3.74289009
30response to pheromone (GO:0019236)3.68526911
31response to methylmercury (GO:0051597)3.63402644
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.63296226
33valine metabolic process (GO:0006573)3.58020404
34protein complex biogenesis (GO:0070271)3.55780080
35aspartate family amino acid catabolic process (GO:0009068)3.49451299
36NADH metabolic process (GO:0006734)3.48820641
37inositol phosphate catabolic process (GO:0071545)3.48446479
38positive regulation of fatty acid beta-oxidation (GO:0032000)3.47745982
39carnitine transport (GO:0015879)3.47166889
40amino-acid betaine transport (GO:0015838)3.47166889
41monocarboxylic acid catabolic process (GO:0072329)3.45817234
42respiratory chain complex IV assembly (GO:0008535)3.42545972
43acyl-CoA biosynthetic process (GO:0071616)3.41932161
44thioester biosynthetic process (GO:0035384)3.41932161
45cytidine metabolic process (GO:0046087)3.39540875
46cytidine catabolic process (GO:0006216)3.39540875
47cytidine deamination (GO:0009972)3.39540875
48carnitine transmembrane transport (GO:1902603)3.37974130
49preassembly of GPI anchor in ER membrane (GO:0016254)3.36672978
50branched-chain amino acid metabolic process (GO:0009081)3.32891494
51ketone body metabolic process (GO:1902224)3.32058351
52replication fork processing (GO:0031297)3.31699389
53negative regulation of mast cell activation (GO:0033004)3.31111250
54regulation of fatty acid oxidation (GO:0046320)3.30801083
55indolalkylamine metabolic process (GO:0006586)3.27504608
56mitochondrial respiratory chain complex assembly (GO:0033108)3.27501458
57ubiquinone biosynthetic process (GO:0006744)3.27176188
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26037698
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.26037698
60NADH dehydrogenase complex assembly (GO:0010257)3.26037698
61branched-chain amino acid catabolic process (GO:0009083)3.24743663
62positive regulation of fatty acid oxidation (GO:0046321)3.24298259
63drug transmembrane transport (GO:0006855)3.24185086
64indole-containing compound catabolic process (GO:0042436)3.23441530
65indolalkylamine catabolic process (GO:0046218)3.23441530
66tryptophan catabolic process (GO:0006569)3.23441530
67porphyrin-containing compound biosynthetic process (GO:0006779)3.22004717
68tricarboxylic acid cycle (GO:0006099)3.21876006
69negative regulation of neurotransmitter secretion (GO:0046929)3.21482594
70protein-cofactor linkage (GO:0018065)3.21479969
71succinate metabolic process (GO:0006105)3.20928768
72pyrimidine ribonucleoside catabolic process (GO:0046133)3.20418836
73alpha-linolenic acid metabolic process (GO:0036109)3.17247732
74protein K11-linked deubiquitination (GO:0035871)3.16852352
75triglyceride catabolic process (GO:0019433)3.16426025
762-oxoglutarate metabolic process (GO:0006103)3.14740127
77ubiquinone metabolic process (GO:0006743)3.14215918
78detection of light stimulus involved in visual perception (GO:0050908)3.14138524
79detection of light stimulus involved in sensory perception (GO:0050962)3.14138524
80aromatic amino acid family catabolic process (GO:0009074)3.13364053
81inositol phosphate dephosphorylation (GO:0046855)3.13238992
82phosphorylated carbohydrate dephosphorylation (GO:0046838)3.13238992
83regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.13060102
84fatty-acyl-CoA biosynthetic process (GO:0046949)3.11636375
85fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.09364230
86quaternary ammonium group transport (GO:0015697)3.09256622
87regulation of triglyceride catabolic process (GO:0010896)3.09205764
88L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08505591
89multicellular organism reproduction (GO:0032504)3.05629748
90neutral lipid catabolic process (GO:0046461)3.04686335
91acylglycerol catabolic process (GO:0046464)3.04686335
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03224658
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03224658
94regulation of acyl-CoA biosynthetic process (GO:0050812)3.03042022
95organelle membrane fusion (GO:0090174)3.01528856
96protein deneddylation (GO:0000338)3.01502092
97glyoxylate metabolic process (GO:0046487)3.01199624
98cytochrome complex assembly (GO:0017004)2.99438485
99C-terminal protein lipidation (GO:0006501)2.99304082
100sulfation (GO:0051923)2.98981939
101tetrapyrrole biosynthetic process (GO:0033014)2.98525231
102proteasome assembly (GO:0043248)2.96745223
103acyl-CoA metabolic process (GO:0006637)2.96720869
104thioester metabolic process (GO:0035383)2.96720869
105prenylation (GO:0097354)2.96681526
106protein prenylation (GO:0018342)2.96681526
107C-terminal protein amino acid modification (GO:0018410)2.94752427
108signal peptide processing (GO:0006465)2.94719936
109kynurenine metabolic process (GO:0070189)2.91868091
110heme biosynthetic process (GO:0006783)2.91334741
111tryptophan metabolic process (GO:0006568)2.90680707
112protein neddylation (GO:0045116)2.89623817
113fatty-acyl-CoA metabolic process (GO:0035337)2.89332723
114dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.89158626
115cullin deneddylation (GO:0010388)2.88972642
116regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.87012903
117nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84551135
118response to phenylpropanoid (GO:0080184)2.84134945
119polyol catabolic process (GO:0046174)2.83884316
120positive regulation of prostaglandin secretion (GO:0032308)2.83724366
121long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.83488318
122myelin maintenance (GO:0043217)2.83326216
123positive regulation of defense response to virus by host (GO:0002230)2.82468806
124DNA catabolic process, exonucleolytic (GO:0000738)2.80847861
125GPI anchor metabolic process (GO:0006505)2.80843082
126regulation of fatty acid beta-oxidation (GO:0031998)2.79885629
127triglyceride biosynthetic process (GO:0019432)2.78569902
128pseudouridine synthesis (GO:0001522)2.78343293
129response to mercury ion (GO:0046689)2.77760374
130intracellular lipid transport (GO:0032365)2.77725783
131exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77469886
132DNA demethylation (GO:0080111)2.77342454
133oxidative demethylation (GO:0070989)2.77207549
134adenosine metabolic process (GO:0046085)2.76682803
135L-methionine salvage (GO:0071267)2.76466546
136L-methionine biosynthetic process (GO:0071265)2.76466546
137amino acid salvage (GO:0043102)2.76466546
138glycine transport (GO:0015816)2.76132037
139recombinational repair (GO:0000725)2.74336842
140double-strand break repair via homologous recombination (GO:0000724)2.74205245
141negative regulation of transcription regulatory region DNA binding (GO:2000678)2.73913258
142porphyrin-containing compound metabolic process (GO:0006778)2.73343011
143regulation of mitotic spindle checkpoint (GO:1903504)2.72993198
144regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.72993198
145amino-acid betaine metabolic process (GO:0006577)2.72632419
146ethanol oxidation (GO:0006069)2.71278429
147neutral lipid biosynthetic process (GO:0046460)2.70678252
148acylglycerol biosynthetic process (GO:0046463)2.70678252
149RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69270358
150regulation of cilium movement (GO:0003352)2.69152874
151cellular ketone body metabolic process (GO:0046950)2.67159563
152protein localization to endosome (GO:0036010)2.66258730
153tRNA processing (GO:0008033)2.65629213
154response to lead ion (GO:0010288)2.65078707
155piRNA metabolic process (GO:0034587)2.64725155
156regulation of cholesterol metabolic process (GO:0090181)2.63607144
157detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63163472
158maturation of 5.8S rRNA (GO:0000460)2.62761089
159neural tube formation (GO:0001841)2.62714050
160transcytosis (GO:0045056)2.62270502
161triglyceride metabolic process (GO:0006641)2.61801216
162negative regulation of telomere maintenance (GO:0032205)2.61339326
163peptidyl-histidine modification (GO:0018202)2.61238770
164carnitine metabolic process (GO:0009437)2.61183075
165regulation of cofactor metabolic process (GO:0051193)2.60764735
166regulation of coenzyme metabolic process (GO:0051196)2.60764735
167positive regulation of lipid catabolic process (GO:0050996)2.60532585
168creatine metabolic process (GO:0006600)2.60424882
169methionine biosynthetic process (GO:0009086)2.59798278
170negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.58822275
171intra-S DNA damage checkpoint (GO:0031573)2.58331383
172mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.58192509
173organic acid catabolic process (GO:0016054)2.57134348
174carboxylic acid catabolic process (GO:0046395)2.57134348
175long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.56290925
176glutamate metabolic process (GO:0006536)2.56265854
177glycerolipid catabolic process (GO:0046503)2.55331105
178anterograde synaptic vesicle transport (GO:0048490)2.55298876
179protein K6-linked ubiquitination (GO:0085020)2.53648681
180rRNA modification (GO:0000154)2.52214404
181negative regulation of neurotransmitter transport (GO:0051589)2.51629844
182acylglycerol metabolic process (GO:0006639)2.51588460
183neutral lipid metabolic process (GO:0006638)2.50824422
184low-density lipoprotein particle clearance (GO:0034383)2.49193071
185S-adenosylmethionine metabolic process (GO:0046500)2.48981368
186quinone biosynthetic process (GO:1901663)2.48873595
187axon ensheathment in central nervous system (GO:0032291)2.48869300
188central nervous system myelination (GO:0022010)2.48869300
189heme metabolic process (GO:0042168)2.48386599
190DNA dealkylation (GO:0035510)2.47859157
191negative regulation of lipase activity (GO:0060192)2.47544913
192regulation of memory T cell differentiation (GO:0043380)2.46735561
193very long-chain fatty acid metabolic process (GO:0000038)2.45899698
194negative regulation of digestive system process (GO:0060457)2.45584197
195positive regulation of glycolytic process (GO:0045821)2.43579763
196regulation of sulfur metabolic process (GO:0042762)2.40360052
197autophagic vacuole fusion (GO:0000046)2.39973771
198GPI anchor biosynthetic process (GO:0006506)2.39960730
199peptidyl-tyrosine autophosphorylation (GO:0038083)2.39890259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.11782501
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.42318459
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.39276874
4ZNF274_21170338_ChIP-Seq_K562_Hela3.56543298
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.30083105
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.01825368
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00160241
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.91439762
9GATA1_22025678_ChIP-Seq_K562_Human2.70402893
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.69747219
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62909997
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.58938943
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57081929
14VDR_22108803_ChIP-Seq_LS180_Human2.51805573
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.45621701
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.29068609
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.28066810
18ELK1_19687146_ChIP-ChIP_HELA_Human2.27736355
19GATA1_19941826_ChIP-Seq_K562_Human2.27733954
20IGF1R_20145208_ChIP-Seq_DFB_Human2.15109462
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.12214017
22VDR_23849224_ChIP-Seq_CD4+_Human2.10556717
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07902680
24EWS_26573619_Chip-Seq_HEK293_Human2.02408404
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00179713
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98639713
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87806436
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.85541628
29P300_19829295_ChIP-Seq_ESCs_Human1.83474651
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.79880206
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75400828
32FUS_26573619_Chip-Seq_HEK293_Human1.74791741
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73147113
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.71597649
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.68971316
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68638212
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68197938
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65572549
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64498033
40AR_21572438_ChIP-Seq_LNCaP_Human1.64052810
41CLOCK_20551151_ChIP-Seq_293T_Human1.63604782
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62924749
43TP53_22573176_ChIP-Seq_HFKS_Human1.62571018
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60396075
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60019875
46MYC_18940864_ChIP-ChIP_HL60_Human1.59926942
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59008583
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.58699786
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57457588
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.56072557
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53387522
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51803389
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50469341
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48142696
55GBX2_23144817_ChIP-Seq_PC3_Human1.47364352
56CBP_20019798_ChIP-Seq_JUKART_Human1.46867220
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46867220
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45985100
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45985100
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.45197391
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44495332
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.43590129
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42061536
64GATA2_19941826_ChIP-Seq_K562_Human1.41614548
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.38937464
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38613686
67IRF1_19129219_ChIP-ChIP_H3396_Human1.38446533
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36956254
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.36881991
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.36606139
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.36252585
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36000446
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33014539
74NANOG_19829295_ChIP-Seq_ESCs_Human1.32175945
75SOX2_19829295_ChIP-Seq_ESCs_Human1.32175945
76EZH2_22144423_ChIP-Seq_EOC_Human1.31882047
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31170463
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30220261
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.30076465
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29502243
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29459073
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29450406
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.29450406
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26989470
85DROSHA_22980978_ChIP-Seq_HELA_Human1.26785063
86JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26466758
87BCAT_22108803_ChIP-Seq_LS180_Human1.26072226
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24593007
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.24469884
90AR_20517297_ChIP-Seq_VCAP_Human1.24336218
91SMAD4_21799915_ChIP-Seq_A2780_Human1.24055687
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23971962
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21181248
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20884086
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20819043
96KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.20267174
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19517972
98AR_25329375_ChIP-Seq_VCAP_Human1.18793664
99FOXP3_21729870_ChIP-Seq_TREG_Human1.18000162
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17981335
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.17534946
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17448323
103ZNF263_19887448_ChIP-Seq_K562_Human1.17430830
104SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17335695
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16730730
106EED_16625203_ChIP-ChIP_MESCs_Mouse1.16444413
107STAT3_23295773_ChIP-Seq_U87_Human1.15181986
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14878510
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.14598429
110SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14493521
111TCF4_23295773_ChIP-Seq_U87_Human1.14365292
112TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.14234781
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.14011678
114CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14008455
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13984878
116SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12563736
117GATA3_26560356_Chip-Seq_TH2_Human1.12294321
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12058613
119IRF8_22096565_ChIP-ChIP_GC-B_Human1.10869709
120SCL_19346495_ChIP-Seq_HPC-7_Human1.10677701
121CDX2_22108803_ChIP-Seq_LS180_Human1.09189090
122NCOR_22424771_ChIP-Seq_293T_Human1.08433927
123KDM2B_26808549_Chip-Seq_K562_Human1.08265506
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08077468
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07202052
126EZH2_27294783_Chip-Seq_ESCs_Mouse1.07101071
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06873084
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06754042
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06355179
130GATA2_21666600_ChIP-Seq_HMVEC_Human1.06191270
131WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06162234
132EZH2_27304074_Chip-Seq_ESCs_Mouse1.06088231
133LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05085807
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05033120
135NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05033120
136RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04474996
137HOXB7_26014856_ChIP-Seq_BT474_Human1.04322335
138E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03849750
139TBX20_22328084_ChIP-Seq_HEART_Mouse1.02769246
140TBX20_22080862_ChIP-Seq_HEART_Mouse1.02769246
141ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02130010
142RARB_27405468_Chip-Seq_BRAIN_Mouse1.01629740
143TCF4_22108803_ChIP-Seq_LS180_Human1.00681853
144SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00579428
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00450006
146FOXH1_21741376_ChIP-Seq_EPCs_Human1.00245859
147FOXA1_25552417_ChIP-Seq_VCAP_Human1.00072192
148P53_22387025_ChIP-Seq_ESCs_Mouse0.98735339
149PRDM14_20953172_ChIP-Seq_ESCs_Human0.98173812
150STAT3_18555785_Chip-Seq_ESCs_Mouse0.98157804
151HTT_18923047_ChIP-ChIP_STHdh_Human0.97727461
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97612597
153AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97263940
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97083774
155NANOG_18555785_Chip-Seq_ESCs_Mouse0.96485062
156PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95612967
157SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95486845
158TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95344204
159EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95124994
160ERG_20517297_ChIP-Seq_VCAP_Human0.94317267
161TP53_18474530_ChIP-ChIP_U2OS_Human0.94041454
162TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94012206
163PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93940251
164RXR_22108803_ChIP-Seq_LS180_Human0.93429065
165SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93230635
166PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92878037
167TAF15_26573619_Chip-Seq_HEK293_Human0.92260011
168AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90242563
169AHR_22903824_ChIP-Seq_MCF-7_Human0.90077768
170ARNT_22903824_ChIP-Seq_MCF-7_Human0.89544532
171ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89431326
172CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88977721
173VDR_24787735_ChIP-Seq_THP-1_Human0.88862453
174WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87659906
175FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86725665
176PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86214403
177SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84773216
178FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84031127
179VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83924849
180PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83664301
181RNF2_27304074_Chip-Seq_ESCs_Mouse0.82897256
182ISL1_27105846_Chip-Seq_CPCs_Mouse0.80540639
183POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79074688
184KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78796713
185ER_23166858_ChIP-Seq_MCF-7_Human0.77855163
186SOX2_21211035_ChIP-Seq_LN229_Gbm0.77320447
187FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76660955
188SMAD4_21741376_ChIP-Seq_HESCs_Human0.76641198

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.92924166
2MP0005360_urolithiasis3.71143105
3MP0003656_abnormal_erythrocyte_physiolo3.31914795
4MP0004130_abnormal_muscle_cell3.14575942
5MP0004147_increased_porphyrin_level3.10100905
6MP0005365_abnormal_bile_salt2.95574068
7MP0004185_abnormal_adipocyte_glucose2.89607183
8MP0000569_abnormal_digit_pigmentation2.84704588
9MP0005085_abnormal_gallbladder_physiolo2.81174759
10MP0005083_abnormal_biliary_tract2.79545991
11MP0005666_abnormal_adipose_tissue2.69398858
12MP0004043_abnormal_pH_regulation2.66805233
13MP0008877_abnormal_DNA_methylation2.55187514
14MP0005670_abnormal_white_adipose2.54182962
15MP0008875_abnormal_xenobiotic_pharmacok2.49653014
16MP0002837_dystrophic_cardiac_calcinosis2.47019047
17MP0003195_calcinosis2.39790569
18MP0010329_abnormal_lipoprotein_level2.27815636
19MP0005332_abnormal_amino_acid2.27303758
20MP0000372_irregular_coat_pigmentation2.26594727
21MP0002638_abnormal_pupillary_reflex2.25890789
22MP0002971_abnormal_brown_adipose2.21551208
23MP0002102_abnormal_ear_morphology2.21181424
24MP0002138_abnormal_hepatobiliary_system2.17696046
25MP0002118_abnormal_lipid_homeostasis2.15472404
26MP0005535_abnormal_body_temperature2.14216291
27MP0001666_abnormal_nutrient_absorption2.14192281
28MP0005375_adipose_tissue_phenotype2.08910272
29MP0002234_abnormal_pharynx_morphology2.08479858
30MP0005075_abnormal_melanosome_morpholog2.04264441
31MP0005174_abnormal_tail_pigmentation2.01433737
32MP0008058_abnormal_DNA_repair1.98269273
33MP0005551_abnormal_eye_electrophysiolog1.97022398
34MP0003646_muscle_fatigue1.96994715
35MP0003950_abnormal_plasma_membrane1.96177325
36MP0003806_abnormal_nucleotide_metabolis1.93133403
37MP0006072_abnormal_retinal_apoptosis1.92672534
38MP0003252_abnormal_bile_duct1.91769792
39MP0009780_abnormal_chondrocyte_physiolo1.89401146
40MP0008872_abnormal_physiological_respon1.88111807
41MP0005253_abnormal_eye_physiology1.83167472
42MP0000015_abnormal_ear_pigmentation1.81765633
43MP0000920_abnormal_myelination1.77840355
44MP0000003_abnormal_adipose_tissue1.75118325
45MP0009643_abnormal_urine_homeostasis1.70252789
46MP0006036_abnormal_mitochondrial_physio1.70053217
47MP0005584_abnormal_enzyme/coenzyme_acti1.64486205
48MP0001968_abnormal_touch/_nociception1.64019892
49MP0002160_abnormal_reproductive_system1.61744254
50MP0002078_abnormal_glucose_homeostasis1.61650566
51MP0000013_abnormal_adipose_tissue1.60656491
52MP0000427_abnormal_hair_cycle1.54473534
53MP0008961_abnormal_basal_metabolism1.50984299
54MP0003011_delayed_dark_adaptation1.50267374
55MP0003186_abnormal_redox_activity1.49303039
56MP0003191_abnormal_cellular_cholesterol1.48210541
57MP0005410_abnormal_fertilization1.47761656
58MP0005334_abnormal_fat_pad1.47397111
59MP0003718_maternal_effect1.46758088
60MP0001529_abnormal_vocalization1.46209741
61MP0005646_abnormal_pituitary_gland1.45419100
62MP0005389_reproductive_system_phenotype1.44759853
63MP0001661_extended_life_span1.43974576
64MP0005671_abnormal_response_to1.43269607
65MP0002163_abnormal_gland_morphology1.39864066
66MP0000609_abnormal_liver_physiology1.39678107
67MP0003959_abnormal_lean_body1.37375967
68MP0002876_abnormal_thyroid_physiology1.37339592
69MP0004142_abnormal_muscle_tone1.37067001
70MP0002928_abnormal_bile_duct1.36335001
71MP0002095_abnormal_skin_pigmentation1.35450811
72MP0003300_gastrointestinal_ulcer1.35187567
73MP0002909_abnormal_adrenal_gland1.33452089
74MP0001986_abnormal_taste_sensitivity1.31612666
75MP0005636_abnormal_mineral_homeostasis1.28184008
76MP0003329_amyloid_beta_deposits1.26218132
77MP0001756_abnormal_urination1.24709650
78MP0003690_abnormal_glial_cell1.22606559
79MP0000747_muscle_weakness1.21390711
80MP0001765_abnormal_ion_homeostasis1.20913075
81MP0006276_abnormal_autonomic_nervous1.19531772
82MP0000538_abnormal_urinary_bladder1.19088494
83MP0004145_abnormal_muscle_electrophysio1.19014503
84MP0001919_abnormal_reproductive_system1.17574977
85MP0001764_abnormal_homeostasis1.17188269
86MP0005448_abnormal_energy_balance1.13961840
87MP0009697_abnormal_copulation1.13865099
88MP0005409_darkened_coat_color1.13265093
89MP0000465_gastrointestinal_hemorrhage1.12953607
90MP0003868_abnormal_feces_composition1.12922761
91MP0009046_muscle_twitch1.10819120
92MP0006054_spinal_hemorrhage1.10409282
93MP0002736_abnormal_nociception_after1.09432338
94MP0001905_abnormal_dopamine_level1.09067867
95MP0006035_abnormal_mitochondrial_morpho1.08619775
96MP0002970_abnormal_white_adipose1.08510431
97MP0001879_abnormal_lymphatic_vessel1.06245602
98MP0003786_premature_aging1.06200207
99MP0000230_abnormal_systemic_arterial1.03234041
100MP0009840_abnormal_foam_cell1.02260494
101MP0001944_abnormal_pancreas_morphology1.01766658
102MP0002822_catalepsy1.00934441
103MP0005330_cardiomyopathy1.00861525
104MP0005452_abnormal_adipose_tissue0.99887369
105MP0002938_white_spotting0.99194751
106MP0005367_renal/urinary_system_phenotyp0.98261531
107MP0000516_abnormal_urinary_system0.98261531
108MP0005645_abnormal_hypothalamus_physiol0.96081563
109MP0005220_abnormal_exocrine_pancreas0.94694318
110MP0002148_abnormal_hypersensitivity_rea0.93584857
111MP0010368_abnormal_lymphatic_system0.92721482
112MP0000371_diluted_coat_color0.92266667
113MP0002751_abnormal_autonomic_nervous0.91764762
114MP0009764_decreased_sensitivity_to0.91379887
115MP0001835_abnormal_antigen_presentation0.90450662
116MP0003136_yellow_coat_color0.90097159
117MP0005084_abnormal_gallbladder_morpholo0.90081085
118MP0001324_abnormal_eye_pigmentation0.89744167
119MP0003787_abnormal_imprinting0.89390725
120MP0005195_abnormal_posterior_eye0.86605942
121MP0002972_abnormal_cardiac_muscle0.86140329
122MP0003045_fibrosis0.85993879
123MP0004084_abnormal_cardiac_muscle0.85979276
124MP0004270_analgesia0.85826378
125MP0003953_abnormal_hormone_level0.85677312
126MP0005319_abnormal_enzyme/_coenzyme0.85507432
127MP0000358_abnormal_cell_content/0.85307235
128MP0008775_abnormal_heart_ventricle0.85242190
129MP0001929_abnormal_gametogenesis0.84510712
130MP0004215_abnormal_myocardial_fiber0.84502018
131MP0004859_abnormal_synaptic_plasticity0.84236256
132MP0005187_abnormal_penis_morphology0.83017864
133MP0001984_abnormal_olfaction0.82166366
134MP0004484_altered_response_of0.81697820
135MP0004085_abnormal_heartbeat0.81694653
136MP0009785_altered_susceptibility_to0.81407759
137MP0002693_abnormal_pancreas_physiology0.80542077
138MP0000751_myopathy0.80408683
139MP0005266_abnormal_metabolism0.79915895
140MP0004885_abnormal_endolymph0.79744359
141MP0009115_abnormal_fat_cell0.78593692
142MP0003633_abnormal_nervous_system0.77649901
143MP0003724_increased_susceptibility_to0.77378076
144MP0004019_abnormal_vitamin_homeostasis0.77136678
145MP0005620_abnormal_muscle_contractility0.74632690
146MP0004087_abnormal_muscle_fiber0.74556107
147MP0005386_behavior/neurological_phenoty0.74288945
148MP0004924_abnormal_behavior0.74288945
149MP0004036_abnormal_muscle_relaxation0.73134680
150MP0000653_abnormal_sex_gland0.72639003
151MP0000604_amyloidosis0.72477567
152MP0002272_abnormal_nervous_system0.71246534
153MP0008057_abnormal_DNA_replication0.70652109
154MP0005058_abnormal_lysosome_morphology0.68724339
155MP0001958_emphysema0.67173978
156MP0004272_abnormal_basement_membrane0.66968377
157MP0009642_abnormal_blood_homeostasis0.65700622
158MP0005451_abnormal_body_composition0.65558249
159MP0002136_abnormal_kidney_physiology0.64817463
160MP0002069_abnormal_eating/drinking_beha0.64726302
161MP0001177_atelectasis0.63142753
162MP0005379_endocrine/exocrine_gland_phen0.63091587
163MP0002064_seizures0.62856543
164MP0003635_abnormal_synaptic_transmissio0.62620219
165MP0003221_abnormal_cardiomyocyte_apopto0.61632717
166MP0001544_abnormal_cardiovascular_syste0.60535724
167MP0005385_cardiovascular_system_phenoty0.60535724
168MP0006138_congestive_heart_failure0.60384973
169MP0010386_abnormal_urinary_bladder0.59709054

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.85688782
2Ketoacidosis (HP:0001993)4.36707722
3Ketosis (HP:0001946)4.08554953
4Hyperglycinuria (HP:0003108)3.96342235
5Pancreatic cysts (HP:0001737)3.73842528
6Abnormality of fatty-acid metabolism (HP:0004359)3.72342550
7Poikilocytosis (HP:0004447)3.71265379
8Abnormality of serine family amino acid metabolism (HP:0010894)3.63083184
9Abnormality of glycine metabolism (HP:0010895)3.63083184
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.54836610
11Congenital stationary night blindness (HP:0007642)3.38517635
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.37489022
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.37489022
14Dicarboxylic aciduria (HP:0003215)3.31977556
15Abnormality of dicarboxylic acid metabolism (HP:0010995)3.31977556
16Type II lissencephaly (HP:0007260)3.26792247
173-Methylglutaconic aciduria (HP:0003535)3.21685300
18Hypothermia (HP:0002045)3.20759491
19Abnormality of midbrain morphology (HP:0002418)3.18796393
20Molar tooth sign on MRI (HP:0002419)3.18796393
21Generalized aminoaciduria (HP:0002909)3.14226532
22Increased circulating renin level (HP:0000848)3.10104478
23Mitochondrial inheritance (HP:0001427)3.08820168
24Increased CSF lactate (HP:0002490)3.07582518
25Gout (HP:0001997)3.06368418
26Abnormality of the heme biosynthetic pathway (HP:0010472)3.02753446
27Acute necrotizing encephalopathy (HP:0006965)2.94560118
28True hermaphroditism (HP:0010459)2.94476314
29Hypochromic microcytic anemia (HP:0004840)2.92830754
30Abnormality of the renal cortex (HP:0011035)2.91774280
31Hypokalemic alkalosis (HP:0001949)2.89220916
32Acanthocytosis (HP:0001927)2.88819748
33Abnormal protein N-linked glycosylation (HP:0012347)2.88063522
34Abnormal protein glycosylation (HP:0012346)2.88063522
35Abnormal glycosylation (HP:0012345)2.88063522
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.88063522
37Progressive macrocephaly (HP:0004481)2.87475073
38Hepatocellular necrosis (HP:0001404)2.83726127
39Abnormal gallbladder morphology (HP:0012437)2.82921501
40Hyperammonemia (HP:0001987)2.82055292
41Nephronophthisis (HP:0000090)2.81352303
42Myoglobinuria (HP:0002913)2.81285978
43Cerebral hemorrhage (HP:0001342)2.80791644
44Cholelithiasis (HP:0001081)2.80167499
45Pancreatic fibrosis (HP:0100732)2.79221930
46Hyperinsulinemic hypoglycemia (HP:0000825)2.78882483
47Metabolic alkalosis (HP:0200114)2.78577720
48Abnormality of alanine metabolism (HP:0010916)2.72816711
49Hyperalaninemia (HP:0003348)2.72816711
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.72816711
51Acute encephalopathy (HP:0006846)2.71961826
52Limb hypertonia (HP:0002509)2.69403863
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.69008881
54Abnormal mitochondria in muscle tissue (HP:0008316)2.68292026
55Xanthomatosis (HP:0000991)2.66805187
56Pheochromocytoma (HP:0002666)2.64565777
57Hypoglycemic seizures (HP:0002173)2.64436604
58Medial flaring of the eyebrow (HP:0010747)2.63336750
59Inability to walk (HP:0002540)2.62683462
60Abnormality of macular pigmentation (HP:0008002)2.61582275
61Proximal tubulopathy (HP:0000114)2.61421443
62Hyperactive renin-angiotensin system (HP:0000841)2.59807319
63Attenuation of retinal blood vessels (HP:0007843)2.57770030
64Increased hepatocellular lipid droplets (HP:0006565)2.57262180
65Type I transferrin isoform profile (HP:0003642)2.57186090
66Hyperglycinemia (HP:0002154)2.56627098
67Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56525362
68Lipid accumulation in hepatocytes (HP:0006561)2.56221769
69Metabolic acidosis (HP:0001942)2.54177185
70Deep venous thrombosis (HP:0002625)2.49835699
71Hyperbilirubinemia (HP:0002904)2.46527267
72Chronic hepatic failure (HP:0100626)2.43723376
73Renal Fanconi syndrome (HP:0001994)2.43302803
74Increased serum lactate (HP:0002151)2.42390451
75Abnormality of purine metabolism (HP:0004352)2.42252741
76Abnormality of the renal medulla (HP:0100957)2.41963150
77Methylmalonic acidemia (HP:0002912)2.41489652
78Oligomenorrhea (HP:0000876)2.40619995
79Abnormal biliary tract physiology (HP:0012439)2.39794921
80Bile duct proliferation (HP:0001408)2.39794921
81Cerebellar dysplasia (HP:0007033)2.38121844
82Neurofibrillary tangles (HP:0002185)2.37246039
83Progressive inability to walk (HP:0002505)2.36183545
84Large for gestational age (HP:0001520)2.35975392
85Aplasia/Hypoplasia of the tibia (HP:0005772)2.35316729
86Pancreatic islet-cell hyperplasia (HP:0004510)2.32919156
87Abnormal rod and cone electroretinograms (HP:0008323)2.31890144
88Lactic acidosis (HP:0003128)2.30752706
89Tachypnea (HP:0002789)2.30613311
90Abnormality of the pons (HP:0007361)2.27945849
91Thyroiditis (HP:0100646)2.26108977
92Hyperlipoproteinemia (HP:0010980)2.24695532
93Hydroxyprolinuria (HP:0003080)2.24355752
94Abnormality of proline metabolism (HP:0010907)2.24355752
95Hepatic necrosis (HP:0002605)2.24102685
96Type 2 muscle fiber atrophy (HP:0003554)2.22866208
97Chorioretinal atrophy (HP:0000533)2.21735407
98Hyperuricemia (HP:0002149)2.20721646
99Increased purine levels (HP:0004368)2.20721646
100Hypomagnesemia (HP:0002917)2.20683298
101Reticulocytosis (HP:0001923)2.20209118
102Short tibia (HP:0005736)2.18329681
103Hypoplasia of the pons (HP:0012110)2.14961191
104Abnormality of renin-angiotensin system (HP:0000847)2.14460374
105Neuroendocrine neoplasm (HP:0100634)2.14216038
106Cerebral inclusion bodies (HP:0100314)2.13732355
107Aplasia/hypoplasia of the uterus (HP:0008684)2.11350472
108Conjunctival hamartoma (HP:0100780)2.10903732
109Diaphragmatic weakness (HP:0009113)2.10464585
110Abnormality of chloride homeostasis (HP:0011422)2.10050641
111Abnormal drinking behavior (HP:0030082)2.09384961
112Polydipsia (HP:0001959)2.09384961
113Abnormality of the gallbladder (HP:0005264)2.09241652
114Insomnia (HP:0100785)2.08438748
115Abnormality of endocrine pancreas physiology (HP:0012093)2.08003980
116Abnormality of the pancreatic islet cells (HP:0006476)2.08003980
117Disproportionate short-trunk short stature (HP:0003521)2.05297623
118Intrahepatic cholestasis (HP:0001406)2.05291493
119Vomiting (HP:0002013)2.05056760
120Abnormality of eosinophils (HP:0001879)2.04834922
121Methylmalonic aciduria (HP:0012120)2.04221393
122Albinism (HP:0001022)2.02203816
123Hyperventilation (HP:0002883)2.02013912
124Insidious onset (HP:0003587)2.01491828
125Termporal pattern (HP:0011008)2.01491828
126Abolished electroretinogram (ERG) (HP:0000550)2.01357419
127Exertional dyspnea (HP:0002875)2.01297944
128Eosinophilia (HP:0001880)2.00563876
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99707149
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99040787
131Exercise-induced myalgia (HP:0003738)1.98957994
132Lissencephaly (HP:0001339)1.97687313
133Autoimmune hemolytic anemia (HP:0001890)1.96648760
134Alkalosis (HP:0001948)1.96450398
135Aplasia/Hypoplasia of the fovea (HP:0008060)1.96359288
136Hypoplasia of the fovea (HP:0007750)1.96359288
137Symptomatic seizures (HP:0011145)1.96278754
138Severe muscular hypotonia (HP:0006829)1.95810488
139Renal cortical cysts (HP:0000803)1.94654432
140Epidermoid cyst (HP:0200040)1.93477407
141Increased intramyocellular lipid droplets (HP:0012240)1.93349692
142Cavernous hemangioma (HP:0001048)1.91147121
143Conjugated hyperbilirubinemia (HP:0002908)1.91011730
144Autoimmune thrombocytopenia (HP:0001973)1.91010419
145Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90592522
146Degeneration of the lateral corticospinal tracts (HP:0002314)1.90592522
147Congenital, generalized hypertrichosis (HP:0004540)1.90253967
148Reduced antithrombin III activity (HP:0001976)1.89892461
149Delayed CNS myelination (HP:0002188)1.89881254
150Glycosuria (HP:0003076)1.89793753
151Abnormality of urine glucose concentration (HP:0011016)1.89793753
152Hyperglycemia (HP:0003074)1.89187790
153Sensory axonal neuropathy (HP:0003390)1.88715679
154Increased muscle lipid content (HP:0009058)1.88602964
155Stomatitis (HP:0010280)1.86839868
156Onion bulb formation (HP:0003383)1.86738527
157Hyperkalemia (HP:0002153)1.86276404
158Paralysis (HP:0003470)1.85497071
159Axonal loss (HP:0003447)1.85420141
160Retinal dysplasia (HP:0007973)1.85117232
161IgG deficiency (HP:0004315)1.84361359
162Hepatocellular carcinoma (HP:0001402)1.84319158
163Respiratory failure (HP:0002878)1.83586236
164Tubular atrophy (HP:0000092)1.82570257
165Birth length less than 3rd percentile (HP:0003561)1.82346017
166Fair hair (HP:0002286)1.81792856
167Abnormality of the fovea (HP:0000493)1.81697206
168Hypoalbuminemia (HP:0003073)1.81096049
169Abnormal albumin level (HP:0012116)1.81096049
170Hyperaldosteronism (HP:0000859)1.80209239
171Congenital sensorineural hearing impairment (HP:0008527)1.79774483
172Poor head control (HP:0002421)1.79123018
173Polycythemia (HP:0001901)1.78991997
174Constricted visual fields (HP:0001133)1.78604936
175Rhabdomyolysis (HP:0003201)1.78543307
176Optic disc pallor (HP:0000543)1.77387764
177Abnormality of potassium homeostasis (HP:0011042)1.77146361
178Brushfield spots (HP:0001088)1.76639887
179Abnormality of magnesium homeostasis (HP:0004921)1.76594710
180Furrowed tongue (HP:0000221)1.76029987
181Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75850563
182Hyporeflexia of lower limbs (HP:0002600)1.74406397
183Cerebral edema (HP:0002181)1.73862840
184Muscle fiber atrophy (HP:0100295)1.73233850
185Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72479779
186Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72474886
187Insulin-resistant diabetes mellitus (HP:0000831)1.72472297
188Visceral angiomatosis (HP:0100761)1.72090494
189Pancreatitis (HP:0001733)1.71295878
190Ileus (HP:0002595)1.70620418
191Lethargy (HP:0001254)1.70273143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.63415730
2ZAK3.61275984
3TRIB33.58846379
4WNK43.25121028
5ADRBK23.00937507
6BCKDK2.98562403
7STK392.96493586
8OXSR12.88372937
9EIF2AK32.69498485
10BMPR1B2.61843880
11CAMK1G2.53092569
12TRIM282.28634837
13PINK12.20403424
14MAP4K22.16498225
15MAP3K102.11978385
16CAMK1D2.06303750
17NUAK12.01919164
18ACVR1B1.98997668
19SIK11.95598612
20MST41.92449154
21FGFR21.83765744
22CAMKK21.78949584
23WNK11.77966362
24EIF2AK11.77661710
25TAOK31.76183735
26EPHB11.70972192
27GRK11.68732766
28TXK1.63367728
29SGK4941.53971801
30SGK2231.53971801
31PKN11.53921469
32NTRK11.49912297
33MET1.40614806
34RET1.40001617
35ERN11.38300872
36ERBB31.34042821
37MAPKAPK51.27659806
38WNK31.27463502
39HIPK21.27019928
40PRKAA21.26842377
41TIE11.26687809
42MUSK1.23645800
43VRK11.21147403
44BMPR21.20901462
45MARK31.19081938
46MAP3K71.12285186
47ADRBK11.08889690
48PLK21.08436919
49PDPK11.08372466
50TEC1.04592748
51OBSCN1.03862586
52PRKD11.02828114
53PKN21.02735751
54SGK31.00746682
55TLK10.99844941
56DAPK20.99377890
57PRKD30.97994258
58STK160.97206903
59PAK30.96732392
60PDK30.95644749
61PDK40.95644749
62UHMK10.95471256
63PIK3CA0.95358252
64IKBKB0.94775077
65MAP3K20.93800680
66MAPKAPK30.93771371
67PRKCH0.92714270
68PRKAA10.92698961
69CSNK1G20.92464996
70NTRK30.92154524
71PHKG10.91047019
72PHKG20.91047019
73AKT30.90479842
74MAP3K10.90211309
75FGFR40.89510213
76FLT30.87572640
77CDK90.85973898
78SRPK10.85214095
79CSNK1G30.84317815
80IRAK10.84149399
81MYLK0.83974166
82JAK20.83904011
83MAP3K120.83118359
84STK40.82471939
85MARK20.82196464
86CSNK1A1L0.81767517
87RPS6KA50.80990908
88SGK20.80723021
89NLK0.80257220
90MAPK130.79066999
91MAP2K10.76717269
92CDK60.76146207
93TAOK10.74217706
94SCYL20.73071089
95KSR20.72441960
96PDK10.72269523
97MAPK110.71426811
98PLK30.70887282
99BRSK20.70778831
100STK30.68660012
101CDK50.68169177
102PDGFRB0.66782510
103MAP2K40.66530948
104EPHA30.66328401
105STK38L0.64929984
106FRK0.64801656
107CDK190.64535283
108LRRK20.63984542
109STK110.63955607
110BCR0.63465755
111CSNK1G10.63435933
112TNIK0.63357457
113PTK60.62987842
114GRK70.62861704
115NEK90.62735306
116PRKCI0.62669952
117TRPM70.62338791
118CCNB10.62110973
119PRKCG0.61956081
120MAP3K40.61718615
121TGFBR10.60632227
122MAPK120.60248012
123CASK0.58388921
124MKNK20.57853038
125CAMK2B0.57225224
126PRKCE0.57060384
127SYK0.56991265
128PRKCQ0.56364698
129SGK10.55644726
130GRK60.54493371
131MST1R0.51307286
132MAP2K60.50462451
133CDK80.50407556
134DMPK0.48477960
135PRKACG0.48418555
136PTK2B0.48153526
137MARK10.47455955
138PRKD20.47061838
139IRAK20.45949002
140FGFR30.45691709
141PIK3CG0.45568548
142MAPK150.45439668
143CLK10.45362893
144PTK20.44916503
145PNCK0.44301469
146KDR0.44078269
147FES0.42347852
148JAK10.42235812
149GSK3A0.42234821
150BTK0.42066382
151FER0.41924586
152DYRK20.40478378
153LMTK20.40369320
154PDGFRA0.40325986
155FYN0.39871725
156CAMK2D0.39144447
157PDK20.38945378
158MAP2K70.37985563
159EIF2AK20.37467587
160ITK0.37019381
161ABL20.36529409
162TAF10.36262430
163ZAP700.34983501
164LCK0.32110992
165LIMK10.32088490
166IGF1R0.31348288
167ILK0.30993851
168KIT0.29671061
169GRK50.29552139
170IKBKE0.29287479
171ABL10.28420436

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.34842654
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.20682406
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.15247612
4Fatty acid degradation_Homo sapiens_hsa000712.97598921
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.83963520
6Fatty acid metabolism_Homo sapiens_hsa012122.72714482
7Butanoate metabolism_Homo sapiens_hsa006502.65234605
8RNA polymerase_Homo sapiens_hsa030202.64100434
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.49683756
10Proteasome_Homo sapiens_hsa030502.43839680
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.23260348
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20579782
13Phototransduction_Homo sapiens_hsa047442.17204174
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.13519100
15PPAR signaling pathway_Homo sapiens_hsa033202.12390495
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12345884
17Fatty acid elongation_Homo sapiens_hsa000622.09771647
18Basal transcription factors_Homo sapiens_hsa030222.07416212
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00742470
20Tryptophan metabolism_Homo sapiens_hsa003801.98203391
21Nitrogen metabolism_Homo sapiens_hsa009101.96001496
22Sulfur metabolism_Homo sapiens_hsa009201.91505224
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87015198
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.84590219
25Homologous recombination_Homo sapiens_hsa034401.81648680
26Pyruvate metabolism_Homo sapiens_hsa006201.81593086
27Fanconi anemia pathway_Homo sapiens_hsa034601.78736320
28Linoleic acid metabolism_Homo sapiens_hsa005911.76272663
29Fatty acid biosynthesis_Homo sapiens_hsa000611.62481090
30Peroxisome_Homo sapiens_hsa041461.58958730
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.58294436
32beta-Alanine metabolism_Homo sapiens_hsa004101.57489436
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.57337021
34Regulation of autophagy_Homo sapiens_hsa041401.51749116
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.50342948
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.50201920
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.49871054
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.41172746
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40734469
40RNA degradation_Homo sapiens_hsa030181.40078050
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38484608
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38432931
43One carbon pool by folate_Homo sapiens_hsa006701.33866561
44Glycerolipid metabolism_Homo sapiens_hsa005611.32017853
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29837723
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23515577
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22117995
48Histidine metabolism_Homo sapiens_hsa003401.22002318
49Type I diabetes mellitus_Homo sapiens_hsa049401.21570342
50Huntingtons disease_Homo sapiens_hsa050161.20443902
51Carbon metabolism_Homo sapiens_hsa012001.20266879
52Ether lipid metabolism_Homo sapiens_hsa005651.18851953
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15660992
54Purine metabolism_Homo sapiens_hsa002301.13772624
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11144747
56Arginine biosynthesis_Homo sapiens_hsa002201.07510793
57Asthma_Homo sapiens_hsa053101.07083738
58Lysine degradation_Homo sapiens_hsa003101.05821210
59Fat digestion and absorption_Homo sapiens_hsa049751.05708671
60Bile secretion_Homo sapiens_hsa049761.05374327
61Pyrimidine metabolism_Homo sapiens_hsa002401.05225691
62Graft-versus-host disease_Homo sapiens_hsa053321.04751436
63ABC transporters_Homo sapiens_hsa020101.00320175
64Primary immunodeficiency_Homo sapiens_hsa053400.99928577
65Allograft rejection_Homo sapiens_hsa053300.96900322
66Olfactory transduction_Homo sapiens_hsa047400.95407105
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95005318
68Systemic lupus erythematosus_Homo sapiens_hsa053220.94779086
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92717410
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92283402
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91541160
72Non-homologous end-joining_Homo sapiens_hsa034500.90350700
73Steroid biosynthesis_Homo sapiens_hsa001000.90252115
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.88983396
75Starch and sucrose metabolism_Homo sapiens_hsa005000.87803691
76AMPK signaling pathway_Homo sapiens_hsa041520.87239523
77Autoimmune thyroid disease_Homo sapiens_hsa053200.87173267
78Phenylalanine metabolism_Homo sapiens_hsa003600.85501131
79Insulin resistance_Homo sapiens_hsa049310.85469630
80Caffeine metabolism_Homo sapiens_hsa002320.80955133
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80648777
82Tyrosine metabolism_Homo sapiens_hsa003500.80559860
83Rheumatoid arthritis_Homo sapiens_hsa053230.79407381
84Nucleotide excision repair_Homo sapiens_hsa034200.75947026
85Circadian rhythm_Homo sapiens_hsa047100.75804424
86N-Glycan biosynthesis_Homo sapiens_hsa005100.75574761
87Pancreatic secretion_Homo sapiens_hsa049720.73450636
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72620752
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71599337
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69509915
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67675200
92Cardiac muscle contraction_Homo sapiens_hsa042600.67601444
93Taste transduction_Homo sapiens_hsa047420.67143885
94Glucagon signaling pathway_Homo sapiens_hsa049220.62912402
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61929803
96Protein digestion and absorption_Homo sapiens_hsa049740.61597655
97Renin secretion_Homo sapiens_hsa049240.61051208
98RNA transport_Homo sapiens_hsa030130.60346105
99Cocaine addiction_Homo sapiens_hsa050300.60097365
100Collecting duct acid secretion_Homo sapiens_hsa049660.59612533
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58856451
102Insulin signaling pathway_Homo sapiens_hsa049100.58277036
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58193950
104Insulin secretion_Homo sapiens_hsa049110.57072436
105Type II diabetes mellitus_Homo sapiens_hsa049300.56985146
106Arachidonic acid metabolism_Homo sapiens_hsa005900.56443385
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52961707
108Retinol metabolism_Homo sapiens_hsa008300.52555870
109Gastric acid secretion_Homo sapiens_hsa049710.52164983
110Hematopoietic cell lineage_Homo sapiens_hsa046400.49861456
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49580858
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49197712
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48468150
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47128144
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46478716
116Folate biosynthesis_Homo sapiens_hsa007900.45045891
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.44315196
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.44185131
119Sphingolipid metabolism_Homo sapiens_hsa006000.44105764
120Selenocompound metabolism_Homo sapiens_hsa004500.42854106
121Complement and coagulation cascades_Homo sapiens_hsa046100.42535322
122Morphine addiction_Homo sapiens_hsa050320.41597516
123Dorso-ventral axis formation_Homo sapiens_hsa043200.41144801
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40873908
125Parkinsons disease_Homo sapiens_hsa050120.39886679
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39150026
127Oxidative phosphorylation_Homo sapiens_hsa001900.39088056
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.38590378
129Arginine and proline metabolism_Homo sapiens_hsa003300.36800175
130Vitamin B6 metabolism_Homo sapiens_hsa007500.36784562
131Dopaminergic synapse_Homo sapiens_hsa047280.36246006
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35896697
133Alzheimers disease_Homo sapiens_hsa050100.34696395
134Renal cell carcinoma_Homo sapiens_hsa052110.34416535
135Ovarian steroidogenesis_Homo sapiens_hsa049130.34199667
136Vitamin digestion and absorption_Homo sapiens_hsa049770.34102875
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33363333
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33239485
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33084438
140Thyroid hormone synthesis_Homo sapiens_hsa049180.32677518
141Alcoholism_Homo sapiens_hsa050340.32507303
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32395757
143GABAergic synapse_Homo sapiens_hsa047270.30167192
144Ribosome_Homo sapiens_hsa030100.30125951
145Cholinergic synapse_Homo sapiens_hsa047250.28913096
146cAMP signaling pathway_Homo sapiens_hsa040240.27604216
147Glutathione metabolism_Homo sapiens_hsa004800.27407860
148Chemical carcinogenesis_Homo sapiens_hsa052040.26682424
149Protein export_Homo sapiens_hsa030600.26566040
150Metabolic pathways_Homo sapiens_hsa011000.26547510
151Salivary secretion_Homo sapiens_hsa049700.25940906
152Mineral absorption_Homo sapiens_hsa049780.25633910
153Glioma_Homo sapiens_hsa052140.25264598
154Non-small cell lung cancer_Homo sapiens_hsa052230.24948983
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.24560524
156Vascular smooth muscle contraction_Homo sapiens_hsa042700.24321693
157p53 signaling pathway_Homo sapiens_hsa041150.18905358
158RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18595533

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