

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.17706385 |
| 2 | proteasome assembly (GO:0043248) | 5.28615428 |
| 3 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.63211446 |
| 4 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.61437873 |
| 5 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.55380390 |
| 6 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.30906051 |
| 7 | ATP synthesis coupled proton transport (GO:0015986) | 4.30906051 |
| 8 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.29901522 |
| 9 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.29478207 |
| 10 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.27931171 |
| 11 | cytidine catabolic process (GO:0006216) | 4.26090772 |
| 12 | cytidine deamination (GO:0009972) | 4.26090772 |
| 13 | cytidine metabolic process (GO:0046087) | 4.26090772 |
| 14 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.19679607 |
| 15 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.19679607 |
| 16 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.19679607 |
| 17 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.18333826 |
| 18 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.16368139 |
| 19 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.16368139 |
| 20 | negative regulation of ligase activity (GO:0051352) | 4.15105769 |
| 21 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.15105769 |
| 22 | protein neddylation (GO:0045116) | 4.09174905 |
| 23 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.98536056 |
| 24 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.96772948 |
| 25 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.96772948 |
| 26 | rRNA modification (GO:0000154) | 3.94891350 |
| 27 | respiratory chain complex IV assembly (GO:0008535) | 3.90722536 |
| 28 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.89263699 |
| 29 | protein deneddylation (GO:0000338) | 3.81063467 |
| 30 | cullin deneddylation (GO:0010388) | 3.77238972 |
| 31 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.72431418 |
| 32 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.72133513 |
| 33 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.69289847 |
| 34 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.68028324 |
| 35 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.61209876 |
| 36 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.59343164 |
| 37 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.56867734 |
| 38 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.53107524 |
| 39 | cytochrome complex assembly (GO:0017004) | 3.50763172 |
| 40 | positive regulation of ligase activity (GO:0051351) | 3.45471420 |
| 41 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.43879106 |
| 42 | respiratory electron transport chain (GO:0022904) | 3.40202785 |
| 43 | protein complex biogenesis (GO:0070271) | 3.39706009 |
| 44 | rRNA methylation (GO:0031167) | 3.37676483 |
| 45 | electron transport chain (GO:0022900) | 3.36841156 |
| 46 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.36716315 |
| 47 | DNA double-strand break processing (GO:0000729) | 3.32995187 |
| 48 | regulation of cellular amine metabolic process (GO:0033238) | 3.32088161 |
| 49 | platelet dense granule organization (GO:0060155) | 3.31406776 |
| 50 | positive regulation of cell cycle arrest (GO:0071158) | 3.22559410 |
| 51 | ribosome assembly (GO:0042255) | 3.21875366 |
| 52 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.20835745 |
| 53 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.19893884 |
| 54 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.19893884 |
| 55 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.18990008 |
| 56 | aldehyde catabolic process (GO:0046185) | 3.15747607 |
| 57 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.15250911 |
| 58 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.14201297 |
| 59 | termination of RNA polymerase III transcription (GO:0006386) | 3.14201297 |
| 60 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 3.07131300 |
| 61 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.05722266 |
| 62 | chaperone-mediated protein transport (GO:0072321) | 3.03324837 |
| 63 | regulation of ligase activity (GO:0051340) | 2.96430452 |
| 64 | mannosylation (GO:0097502) | 2.93590138 |
| 65 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.91203807 |
| 66 | isotype switching (GO:0045190) | 2.91203807 |
| 67 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.91203807 |
| 68 | negative regulation of protein ubiquitination (GO:0031397) | 2.88311176 |
| 69 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.87378616 |
| 70 | NADH dehydrogenase complex assembly (GO:0010257) | 2.87378616 |
| 71 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.87378616 |
| 72 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.82763418 |
| 73 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 2.82727633 |
| 74 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.81306191 |
| 75 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.81306191 |
| 76 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.76048284 |
| 77 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.75381248 |
| 78 | oxidative phosphorylation (GO:0006119) | 2.70735446 |
| 79 | GPI anchor biosynthetic process (GO:0006506) | 2.68765590 |
| 80 | response to interferon-beta (GO:0035456) | 2.68450677 |
| 81 | regulation of cell cycle arrest (GO:0071156) | 2.67887629 |
| 82 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.66237687 |
| 83 | B cell mediated immunity (GO:0019724) | 2.65854899 |
| 84 | kynurenine metabolic process (GO:0070189) | 2.65020480 |
| 85 | negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) | 2.61445599 |
| 86 | negative regulation of cell cycle G1/S phase transition (GO:1902807) | 2.61445599 |
| 87 | signal transduction in response to DNA damage (GO:0042770) | 2.60557976 |
| 88 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.58946633 |
| 89 | pseudouridine synthesis (GO:0001522) | 2.53693802 |
| 90 | indole-containing compound catabolic process (GO:0042436) | 2.52837664 |
| 91 | indolalkylamine catabolic process (GO:0046218) | 2.52837664 |
| 92 | tryptophan catabolic process (GO:0006569) | 2.52837664 |
| 93 | response to pheromone (GO:0019236) | 2.52528937 |
| 94 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.51453829 |
| 95 | tryptophan metabolic process (GO:0006568) | 2.51140361 |
| 96 | ATP biosynthetic process (GO:0006754) | 2.50972500 |
| 97 | AMP metabolic process (GO:0046033) | 2.50931875 |
| 98 | cellular ketone body metabolic process (GO:0046950) | 2.50059422 |
| 99 | GPI anchor metabolic process (GO:0006505) | 2.49841044 |
| 100 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.49791455 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.88722737 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.21488254 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.73519781 |
| 4 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.24899820 |
| 5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.13917978 |
| 6 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.12619634 |
| 7 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.95738989 |
| 8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.94662070 |
| 9 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.93340517 |
| 10 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.69123135 |
| 11 | VDR_22108803_ChIP-Seq_LS180_Human | 2.68607404 |
| 12 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.66777783 |
| 13 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.44859290 |
| 14 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.43606740 |
| 15 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.37313616 |
| 16 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.34319790 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.18732714 |
| 18 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.17053441 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.15661387 |
| 20 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.08784871 |
| 21 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.03640683 |
| 22 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.98495770 |
| 23 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.95257160 |
| 24 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.91161846 |
| 25 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.89270865 |
| 26 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.82338890 |
| 27 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.80279413 |
| 28 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.69579276 |
| 29 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.68940274 |
| 30 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.64174482 |
| 31 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.59973129 |
| 32 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.59274526 |
| 33 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.58649122 |
| 34 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.57757257 |
| 35 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.57428691 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.56199319 |
| 37 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.50943290 |
| 38 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.47731178 |
| 39 | EWS_26573619_Chip-Seq_HEK293_Human | 1.43970324 |
| 40 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.39655440 |
| 41 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.38548567 |
| 42 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.37529100 |
| 43 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.37000461 |
| 44 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.36319151 |
| 45 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.35010178 |
| 46 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.34356128 |
| 47 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.33219192 |
| 48 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.32999118 |
| 49 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.32999118 |
| 50 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.32629261 |
| 51 | GATA3_26560356_Chip-Seq_TH2_Human | 1.30888126 |
| 52 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.28856465 |
| 53 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.23719671 |
| 54 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.23405237 |
| 55 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.22888960 |
| 56 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.22626341 |
| 57 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22624666 |
| 58 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.21876179 |
| 59 | FUS_26573619_Chip-Seq_HEK293_Human | 1.21404740 |
| 60 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.20275712 |
| 61 | AR_20517297_ChIP-Seq_VCAP_Human | 1.20193504 |
| 62 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.19666162 |
| 63 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.19666162 |
| 64 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.19594578 |
| 65 | P300_19829295_ChIP-Seq_ESCs_Human | 1.18950761 |
| 66 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.16029051 |
| 67 | MYB_26560356_Chip-Seq_TH2_Human | 1.14627928 |
| 68 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.12961935 |
| 69 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.11844937 |
| 70 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.11580586 |
| 71 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.10738449 |
| 72 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.07887120 |
| 73 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.07676980 |
| 74 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.06823571 |
| 75 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.06305700 |
| 76 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.05067417 |
| 77 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.05009051 |
| 78 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.04534593 |
| 79 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.03504461 |
| 80 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.03363411 |
| 81 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.03208893 |
| 82 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.01444327 |
| 83 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.01135051 |
| 84 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.00596932 |
| 85 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.98261325 |
| 86 | NCOR_22424771_ChIP-Seq_293T_Human | 0.96774667 |
| 87 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.96152114 |
| 88 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.94785833 |
| 89 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.94785833 |
| 90 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.93951255 |
| 91 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.93505764 |
| 92 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.93270972 |
| 93 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.93213441 |
| 94 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.90771478 |
| 95 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.88878215 |
| 96 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.88487513 |
| 97 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.88304758 |
| 98 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.87906367 |
| 99 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.87893140 |
| 100 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.87448222 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 3.64222008 |
| 2 | MP0001835_abnormal_antigen_presentation | 3.46073422 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 2.88979853 |
| 4 | MP0008058_abnormal_DNA_repair | 2.86829365 |
| 5 | MP0002102_abnormal_ear_morphology | 2.78918529 |
| 6 | MP0004147_increased_porphyrin_level | 2.78677171 |
| 7 | MP0003195_calcinosis | 2.71479905 |
| 8 | MP0002166_altered_tumor_susceptibility | 2.43888230 |
| 9 | MP0009785_altered_susceptibility_to | 2.43232705 |
| 10 | MP0006072_abnormal_retinal_apoptosis | 2.32687106 |
| 11 | MP0008875_abnormal_xenobiotic_pharmacok | 2.30474827 |
| 12 | MP0003786_premature_aging | 2.22428510 |
| 13 | MP0002006_tumorigenesis | 2.22119990 |
| 14 | MP0005084_abnormal_gallbladder_morpholo | 2.19827031 |
| 15 | MP0008877_abnormal_DNA_methylation | 2.17916467 |
| 16 | MP0006036_abnormal_mitochondrial_physio | 2.08619607 |
| 17 | MP0010094_abnormal_chromosome_stability | 2.08540340 |
| 18 | MP0009333_abnormal_splenocyte_physiolog | 2.04250811 |
| 19 | MP0002148_abnormal_hypersensitivity_rea | 1.98478952 |
| 20 | MP0008872_abnormal_physiological_respon | 1.96912790 |
| 21 | MP0009697_abnormal_copulation | 1.83273908 |
| 22 | MP0005410_abnormal_fertilization | 1.82800871 |
| 23 | MP0005645_abnormal_hypothalamus_physiol | 1.80592823 |
| 24 | MP0000685_abnormal_immune_system | 1.70671199 |
| 25 | MP0001873_stomach_inflammation | 1.68473732 |
| 26 | MP0005075_abnormal_melanosome_morpholog | 1.64040792 |
| 27 | MP0003878_abnormal_ear_physiology | 1.62510219 |
| 28 | MP0005377_hearing/vestibular/ear_phenot | 1.62510219 |
| 29 | MP0003718_maternal_effect | 1.60908748 |
| 30 | MP0002138_abnormal_hepatobiliary_system | 1.59123592 |
| 31 | MP0001800_abnormal_humoral_immune | 1.55898377 |
| 32 | MP0005000_abnormal_immune_tolerance | 1.52395999 |
| 33 | MP0002837_dystrophic_cardiac_calcinosis | 1.47841347 |
| 34 | MP0008007_abnormal_cellular_replicative | 1.47173112 |
| 35 | MP0004957_abnormal_blastocyst_morpholog | 1.43004281 |
| 36 | MP0003693_abnormal_embryo_hatching | 1.42980230 |
| 37 | MP0001790_abnormal_immune_system | 1.40247134 |
| 38 | MP0005387_immune_system_phenotype | 1.40247134 |
| 39 | MP0000372_irregular_coat_pigmentation | 1.38918201 |
| 40 | MP0003186_abnormal_redox_activity | 1.38157625 |
| 41 | MP0009764_decreased_sensitivity_to | 1.28834841 |
| 42 | MP0005379_endocrine/exocrine_gland_phen | 1.26928388 |
| 43 | MP0003866_abnormal_defecation | 1.26093579 |
| 44 | MP0006035_abnormal_mitochondrial_morpho | 1.25693749 |
| 45 | MP0005636_abnormal_mineral_homeostasis | 1.24531607 |
| 46 | MP0005551_abnormal_eye_electrophysiolog | 1.23851829 |
| 47 | MP0002736_abnormal_nociception_after | 1.23835321 |
| 48 | MP0003011_delayed_dark_adaptation | 1.23781011 |
| 49 | MP0003763_abnormal_thymus_physiology | 1.23589018 |
| 50 | MP0002723_abnormal_immune_serum | 1.23080547 |
| 51 | MP0002452_abnormal_antigen_presenting | 1.21905120 |
| 52 | MP0002420_abnormal_adaptive_immunity | 1.21140496 |
| 53 | MP0005367_renal/urinary_system_phenotyp | 1.19567050 |
| 54 | MP0000516_abnormal_urinary_system | 1.19567050 |
| 55 | MP0006054_spinal_hemorrhage | 1.19259504 |
| 56 | MP0001905_abnormal_dopamine_level | 1.18918845 |
| 57 | MP0001819_abnormal_immune_cell | 1.18682034 |
| 58 | MP0006082_CNS_inflammation | 1.16157409 |
| 59 | MP0003252_abnormal_bile_duct | 1.15031078 |
| 60 | MP0001968_abnormal_touch/_nociception | 1.14819489 |
| 61 | MP0005332_abnormal_amino_acid | 1.13492353 |
| 62 | MP0005253_abnormal_eye_physiology | 1.12656188 |
| 63 | MP0002693_abnormal_pancreas_physiology | 1.08753533 |
| 64 | MP0003646_muscle_fatigue | 1.03427444 |
| 65 | MP0005025_abnormal_response_to | 1.00560225 |
| 66 | MP0002277_abnormal_respiratory_mucosa | 1.00342204 |
| 67 | MP0000689_abnormal_spleen_morphology | 0.98646258 |
| 68 | MP0001845_abnormal_inflammatory_respons | 0.97904654 |
| 69 | MP0004145_abnormal_muscle_electrophysio | 0.97866410 |
| 70 | MP0001501_abnormal_sleep_pattern | 0.97774888 |
| 71 | MP0002876_abnormal_thyroid_physiology | 0.97073822 |
| 72 | MP0002398_abnormal_bone_marrow | 0.93425207 |
| 73 | MP0001764_abnormal_homeostasis | 0.91849020 |
| 74 | MP0004215_abnormal_myocardial_fiber | 0.91433567 |
| 75 | MP0010155_abnormal_intestine_physiology | 0.91148801 |
| 76 | MP0008775_abnormal_heart_ventricle | 0.90713684 |
| 77 | MP0001929_abnormal_gametogenesis | 0.90271023 |
| 78 | MP0008469_abnormal_protein_level | 0.88249204 |
| 79 | MP0008873_increased_physiological_sensi | 0.87153450 |
| 80 | MP0001984_abnormal_olfaction | 0.87091022 |
| 81 | MP0000716_abnormal_immune_system | 0.86771070 |
| 82 | MP0005085_abnormal_gallbladder_physiolo | 0.86359909 |
| 83 | MP0001765_abnormal_ion_homeostasis | 0.86253986 |
| 84 | MP0001986_abnormal_taste_sensitivity | 0.84477784 |
| 85 | MP0008995_early_reproductive_senescence | 0.80242917 |
| 86 | MP0008057_abnormal_DNA_replication | 0.79399150 |
| 87 | MP0001853_heart_inflammation | 0.78879563 |
| 88 | MP0002019_abnormal_tumor_incidence | 0.78417634 |
| 89 | MP0005319_abnormal_enzyme/_coenzyme | 0.78108597 |
| 90 | MP0005389_reproductive_system_phenotype | 0.77605855 |
| 91 | MP0002419_abnormal_innate_immunity | 0.77039740 |
| 92 | MP0001485_abnormal_pinna_reflex | 0.76484986 |
| 93 | MP0002405_respiratory_system_inflammati | 0.76075384 |
| 94 | MP0002429_abnormal_blood_cell | 0.75482962 |
| 95 | MP0003111_abnormal_nucleus_morphology | 0.75354705 |
| 96 | MP0009643_abnormal_urine_homeostasis | 0.75069032 |
| 97 | MP0001529_abnormal_vocalization | 0.74687912 |
| 98 | MP0002254_reproductive_system_inflammat | 0.73861209 |
| 99 | MP0002722_abnormal_immune_system | 0.73266231 |
| 100 | MP0003077_abnormal_cell_cycle | 0.72798864 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.25442196 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.25148810 |
| 3 | Increased CSF lactate (HP:0002490) | 4.14133046 |
| 4 | Hepatocellular necrosis (HP:0001404) | 3.93062316 |
| 5 | Increased hepatocellular lipid droplets (HP:0006565) | 3.82302392 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.78347337 |
| 7 | Hepatic necrosis (HP:0002605) | 3.77089839 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.71047065 |
| 9 | Acute encephalopathy (HP:0006846) | 3.69868884 |
| 10 | Aplastic anemia (HP:0001915) | 3.44298185 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 3.38369161 |
| 12 | Renal Fanconi syndrome (HP:0001994) | 3.26851352 |
| 13 | Increased serum lactate (HP:0002151) | 3.09305904 |
| 14 | Cerebral edema (HP:0002181) | 3.06119478 |
| 15 | Methylmalonic acidemia (HP:0002912) | 3.01689447 |
| 16 | Hypothermia (HP:0002045) | 2.95901837 |
| 17 | Exertional dyspnea (HP:0002875) | 2.95739327 |
| 18 | Hypoproteinemia (HP:0003075) | 2.94091292 |
| 19 | IgG deficiency (HP:0004315) | 2.92368790 |
| 20 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.84224761 |
| 21 | Lactic acidosis (HP:0003128) | 2.77083829 |
| 22 | Abolished electroretinogram (ERG) (HP:0000550) | 2.75315924 |
| 23 | 3-Methylglutaconic aciduria (HP:0003535) | 2.72024842 |
| 24 | Increased intramyocellular lipid droplets (HP:0012240) | 2.71087132 |
| 25 | Type I transferrin isoform profile (HP:0003642) | 2.64589232 |
| 26 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.63754492 |
| 27 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.63754492 |
| 28 | Methylmalonic aciduria (HP:0012120) | 2.55522183 |
| 29 | Glycosuria (HP:0003076) | 2.53924961 |
| 30 | Abnormality of urine glucose concentration (HP:0011016) | 2.53924961 |
| 31 | Abnormality of the prostate (HP:0008775) | 2.52109948 |
| 32 | Generalized aminoaciduria (HP:0002909) | 2.50575347 |
| 33 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.50431860 |
| 34 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.50119676 |
| 35 | Congenital, generalized hypertrichosis (HP:0004540) | 2.49312217 |
| 36 | Respiratory failure (HP:0002878) | 2.42969949 |
| 37 | IgM deficiency (HP:0002850) | 2.41687294 |
| 38 | Optic disc pallor (HP:0000543) | 2.35834209 |
| 39 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.33001920 |
| 40 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.32817160 |
| 41 | Abnormality of alanine metabolism (HP:0010916) | 2.32817160 |
| 42 | Hyperalaninemia (HP:0003348) | 2.32817160 |
| 43 | Palpitations (HP:0001962) | 2.32548682 |
| 44 | Stomatitis (HP:0010280) | 2.29739479 |
| 45 | Pancreatic cysts (HP:0001737) | 2.29262704 |
| 46 | Lethargy (HP:0001254) | 2.28025966 |
| 47 | Severe combined immunodeficiency (HP:0004430) | 2.23380110 |
| 48 | Abnormality of vitamin B metabolism (HP:0004340) | 2.21301915 |
| 49 | Pancytopenia (HP:0001876) | 2.16512047 |
| 50 | T lymphocytopenia (HP:0005403) | 2.14474506 |
| 51 | Abnormality of T cell number (HP:0011839) | 2.13886489 |
| 52 | Attenuation of retinal blood vessels (HP:0007843) | 2.13304743 |
| 53 | Exercise intolerance (HP:0003546) | 2.13180051 |
| 54 | Abnormal protein glycosylation (HP:0012346) | 2.12806001 |
| 55 | Abnormal glycosylation (HP:0012345) | 2.12806001 |
| 56 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.12806001 |
| 57 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.12806001 |
| 58 | Increased serum pyruvate (HP:0003542) | 2.12426875 |
| 59 | Increased muscle lipid content (HP:0009058) | 2.11411613 |
| 60 | Abnormal spermatogenesis (HP:0008669) | 2.10901236 |
| 61 | Abnormality of methionine metabolism (HP:0010901) | 2.09384138 |
| 62 | Abnormality of serum amino acid levels (HP:0003112) | 2.07589227 |
| 63 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.07161945 |
| 64 | Thyroiditis (HP:0100646) | 2.06549293 |
| 65 | Congenital stationary night blindness (HP:0007642) | 2.05922363 |
| 66 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.03842196 |
| 67 | Abnormality of renal resorption (HP:0011038) | 2.01861099 |
| 68 | Cerebral palsy (HP:0100021) | 2.00112537 |
| 69 | Type 2 muscle fiber atrophy (HP:0003554) | 1.99689487 |
| 70 | Abnormality of T cells (HP:0002843) | 1.99405805 |
| 71 | Abnormality of midbrain morphology (HP:0002418) | 1.95203624 |
| 72 | Molar tooth sign on MRI (HP:0002419) | 1.95203624 |
| 73 | Colon cancer (HP:0003003) | 1.94830709 |
| 74 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.87684624 |
| 75 | Dicarboxylic aciduria (HP:0003215) | 1.87684624 |
| 76 | Abnormality of B cell number (HP:0010975) | 1.87053709 |
| 77 | CNS demyelination (HP:0007305) | 1.86388061 |
| 78 | Nausea (HP:0002018) | 1.84559365 |
| 79 | Posterior subcapsular cataract (HP:0007787) | 1.84397093 |
| 80 | Leukodystrophy (HP:0002415) | 1.82960386 |
| 81 | Hyperphosphaturia (HP:0003109) | 1.82022592 |
| 82 | Nephronophthisis (HP:0000090) | 1.81399258 |
| 83 | Abnormality of glycolysis (HP:0004366) | 1.81125852 |
| 84 | Hypoalbuminemia (HP:0003073) | 1.80680239 |
| 85 | Abnormal albumin level (HP:0012116) | 1.80680239 |
| 86 | Autoimmune hemolytic anemia (HP:0001890) | 1.78555176 |
| 87 | Neoplasm of the adrenal gland (HP:0100631) | 1.77928800 |
| 88 | Tongue fasciculations (HP:0001308) | 1.77895794 |
| 89 | Combined immunodeficiency (HP:0005387) | 1.77570555 |
| 90 | Hypomagnesemia (HP:0002917) | 1.77255332 |
| 91 | Reduced antithrombin III activity (HP:0001976) | 1.76217998 |
| 92 | Respiratory difficulties (HP:0002880) | 1.75282556 |
| 93 | Azoospermia (HP:0000027) | 1.75212529 |
| 94 | Abnormality of the labia minora (HP:0012880) | 1.72346958 |
| 95 | Constricted visual fields (HP:0001133) | 1.71416232 |
| 96 | Abnormality of T cell physiology (HP:0011840) | 1.70190195 |
| 97 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.67371247 |
| 98 | Hypoglycemic coma (HP:0001325) | 1.67296111 |
| 99 | Abnormality of the renal cortex (HP:0011035) | 1.67114074 |
| 100 | Pancreatic fibrosis (HP:0100732) | 1.66258001 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MST4 | 3.05655010 |
| 2 | EIF2AK3 | 3.03255656 |
| 3 | VRK2 | 2.98961761 |
| 4 | TSSK6 | 2.71113408 |
| 5 | TXK | 2.68363211 |
| 6 | NUAK1 | 2.64597653 |
| 7 | ZAK | 2.57155105 |
| 8 | BUB1 | 2.52706770 |
| 9 | MAP3K12 | 2.46255835 |
| 10 | KDR | 2.24653995 |
| 11 | FRK | 2.18070431 |
| 12 | TLK1 | 2.09117015 |
| 13 | TRIM28 | 2.02262398 |
| 14 | MAP4K2 | 1.94865325 |
| 15 | PLK4 | 1.82522172 |
| 16 | VRK1 | 1.81209546 |
| 17 | GRK1 | 1.79929702 |
| 18 | BMPR1B | 1.78409773 |
| 19 | BCKDK | 1.70815956 |
| 20 | EIF2AK1 | 1.70187227 |
| 21 | STK16 | 1.69014853 |
| 22 | TIE1 | 1.65869392 |
| 23 | ADRBK2 | 1.60757177 |
| 24 | PLK3 | 1.60126901 |
| 25 | MKNK2 | 1.58725223 |
| 26 | NEK1 | 1.51565946 |
| 27 | TAOK3 | 1.51025284 |
| 28 | ERBB3 | 1.50730857 |
| 29 | WNK3 | 1.43492310 |
| 30 | DAPK1 | 1.37345981 |
| 31 | TEC | 1.37020182 |
| 32 | MKNK1 | 1.36394896 |
| 33 | SRPK1 | 1.36311094 |
| 34 | PASK | 1.23564193 |
| 35 | MYLK | 1.22665140 |
| 36 | ACVR1B | 1.19001912 |
| 37 | OXSR1 | 1.18196230 |
| 38 | ITK | 1.15743075 |
| 39 | TESK2 | 1.12634327 |
| 40 | BMPR2 | 1.11546039 |
| 41 | SCYL2 | 1.09296586 |
| 42 | NME1 | 1.08229120 |
| 43 | CSNK1G3 | 1.04406006 |
| 44 | INSRR | 1.02841654 |
| 45 | TAF1 | 1.00718557 |
| 46 | EIF2AK2 | 0.98984439 |
| 47 | PLK2 | 0.94400494 |
| 48 | TESK1 | 0.92915844 |
| 49 | PBK | 0.89702589 |
| 50 | CSNK1G1 | 0.88906101 |
| 51 | TNIK | 0.87699871 |
| 52 | WNK4 | 0.84900774 |
| 53 | CSNK1G2 | 0.83357785 |
| 54 | MAP4K1 | 0.82645829 |
| 55 | MAP2K6 | 0.81702475 |
| 56 | STK39 | 0.77430980 |
| 57 | FES | 0.73191165 |
| 58 | PHKG2 | 0.72475525 |
| 59 | PHKG1 | 0.72475525 |
| 60 | CSNK1A1L | 0.72244309 |
| 61 | MAPKAPK3 | 0.71848418 |
| 62 | SYK | 0.67697538 |
| 63 | KIT | 0.66135994 |
| 64 | ALK | 0.65448429 |
| 65 | LIMK1 | 0.63586970 |
| 66 | BCR | 0.62893144 |
| 67 | PLK1 | 0.62886922 |
| 68 | IKBKB | 0.62274106 |
| 69 | TGFBR1 | 0.59242867 |
| 70 | STK38L | 0.58179571 |
| 71 | CDK19 | 0.56710883 |
| 72 | TTK | 0.55163247 |
| 73 | PRKCQ | 0.55158205 |
| 74 | PINK1 | 0.51984646 |
| 75 | CDK8 | 0.50286581 |
| 76 | CDC7 | 0.49910428 |
| 77 | PDK2 | 0.49239669 |
| 78 | PRKCE | 0.47927020 |
| 79 | ATR | 0.47429071 |
| 80 | FLT3 | 0.47122993 |
| 81 | ILK | 0.46302966 |
| 82 | LCK | 0.45396168 |
| 83 | LYN | 0.45080601 |
| 84 | GRK7 | 0.43936281 |
| 85 | GRK5 | 0.43050926 |
| 86 | PIK3CG | 0.43017980 |
| 87 | BRSK2 | 0.42019846 |
| 88 | PAK4 | 0.41574881 |
| 89 | RPS6KA5 | 0.40680690 |
| 90 | MAP3K14 | 0.40128795 |
| 91 | BTK | 0.39267718 |
| 92 | ADRBK1 | 0.38832703 |
| 93 | IGF1R | 0.37887079 |
| 94 | CSNK2A1 | 0.37262401 |
| 95 | WEE1 | 0.37019451 |
| 96 | DAPK2 | 0.36591157 |
| 97 | AURKB | 0.34465297 |
| 98 | ABL1 | 0.32946953 |
| 99 | MAPK13 | 0.32690466 |
| 100 | MAPKAPK5 | 0.32511488 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.36220934 |
| 2 | Asthma_Homo sapiens_hsa05310 | 2.99415273 |
| 3 | Protein export_Homo sapiens_hsa03060 | 2.97981910 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.91915979 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 2.54955478 |
| 6 | Allograft rejection_Homo sapiens_hsa05330 | 2.52902351 |
| 7 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.40728475 |
| 8 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.37190570 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.28146934 |
| 10 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.16549738 |
| 11 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.06296035 |
| 12 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.97821787 |
| 13 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.81403895 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.76155680 |
| 15 | Mismatch repair_Homo sapiens_hsa03430 | 1.72126283 |
| 16 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.71612983 |
| 17 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.67323051 |
| 18 | Homologous recombination_Homo sapiens_hsa03440 | 1.66345353 |
| 19 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.64551030 |
| 20 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.60121798 |
| 21 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.56654105 |
| 22 | Huntingtons disease_Homo sapiens_hsa05016 | 1.55123511 |
| 23 | Alzheimers disease_Homo sapiens_hsa05010 | 1.51945313 |
| 24 | DNA replication_Homo sapiens_hsa03030 | 1.49807113 |
| 25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.47561520 |
| 26 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.39323504 |
| 27 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.38186604 |
| 28 | RNA degradation_Homo sapiens_hsa03018 | 1.37925773 |
| 29 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.27839691 |
| 30 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.26417212 |
| 31 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.25983786 |
| 32 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.25943449 |
| 33 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.23859764 |
| 34 | Basal transcription factors_Homo sapiens_hsa03022 | 1.19578173 |
| 35 | Ribosome_Homo sapiens_hsa03010 | 1.17833587 |
| 36 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.14413410 |
| 37 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.12738310 |
| 38 | RNA transport_Homo sapiens_hsa03013 | 1.11316691 |
| 39 | Base excision repair_Homo sapiens_hsa03410 | 1.08348232 |
| 40 | Purine metabolism_Homo sapiens_hsa00230 | 1.04303364 |
| 41 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.03890483 |
| 42 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.03351818 |
| 43 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.01080868 |
| 44 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.97329224 |
| 45 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.95630159 |
| 46 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.92192875 |
| 47 | Phototransduction_Homo sapiens_hsa04744 | 0.91847126 |
| 48 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.91158160 |
| 49 | Viral myocarditis_Homo sapiens_hsa05416 | 0.90773714 |
| 50 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.90343766 |
| 51 | Peroxisome_Homo sapiens_hsa04146 | 0.89886480 |
| 52 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.85663786 |
| 53 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.84835584 |
| 54 | Spliceosome_Homo sapiens_hsa03040 | 0.80870931 |
| 55 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.79313095 |
| 56 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.78835033 |
| 57 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.78616329 |
| 58 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.78343023 |
| 59 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.77438069 |
| 60 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.75007440 |
| 61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.69060262 |
| 62 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.68532591 |
| 63 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.67729599 |
| 64 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.67405029 |
| 65 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.67031802 |
| 66 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.65277402 |
| 67 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.63850057 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.62863882 |
| 69 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.61916070 |
| 70 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.61815735 |
| 71 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.61368785 |
| 72 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.59589375 |
| 73 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.57741188 |
| 74 | Carbon metabolism_Homo sapiens_hsa01200 | 0.52869589 |
| 75 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.52024278 |
| 76 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.50345245 |
| 77 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.49290671 |
| 78 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.49257837 |
| 79 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.48736394 |
| 80 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.47873863 |
| 81 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.47855277 |
| 82 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.47796942 |
| 83 | Legionellosis_Homo sapiens_hsa05134 | 0.47107790 |
| 84 | Retinol metabolism_Homo sapiens_hsa00830 | 0.47105999 |
| 85 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.44522230 |
| 86 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.43958181 |
| 87 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.43423427 |
| 88 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.43299522 |
| 89 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.43128526 |
| 90 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.42105903 |
| 91 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.41827420 |
| 92 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.40762728 |
| 93 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.38418589 |
| 94 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.37953233 |
| 95 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.37854516 |
| 96 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.37545583 |
| 97 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.33365959 |
| 98 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.31740816 |
| 99 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.30686259 |
| 100 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.28458017 |

