

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.63261124 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 5.35625882 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.35625882 |
| 4 | proteasome assembly (GO:0043248) | 4.75761832 |
| 5 | DNA double-strand break processing (GO:0000729) | 4.74965059 |
| 6 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.65586372 |
| 7 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.56386017 |
| 8 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.43892268 |
| 9 | protein complex biogenesis (GO:0070271) | 4.39141182 |
| 10 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.32980547 |
| 11 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.29965505 |
| 12 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.26938495 |
| 13 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.25918838 |
| 14 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.25918838 |
| 15 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.25918838 |
| 16 | DNA catabolic process, exonucleolytic (GO:0000738) | 4.24462086 |
| 17 | respiratory electron transport chain (GO:0022904) | 4.23607620 |
| 18 | DNA deamination (GO:0045006) | 4.22443703 |
| 19 | electron transport chain (GO:0022900) | 4.19768656 |
| 20 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.19411147 |
| 21 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.19411147 |
| 22 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.15446515 |
| 23 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.15446515 |
| 24 | NADH dehydrogenase complex assembly (GO:0010257) | 4.15446515 |
| 25 | negative regulation of ligase activity (GO:0051352) | 4.12483290 |
| 26 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.12483290 |
| 27 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.12409484 |
| 28 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 4.07664140 |
| 29 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 4.07664140 |
| 30 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.06377380 |
| 31 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 4.02478442 |
| 32 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.93934323 |
| 33 | rRNA modification (GO:0000154) | 3.87240682 |
| 34 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.82907513 |
| 35 | protein neddylation (GO:0045116) | 3.73191689 |
| 36 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.68778609 |
| 37 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.65458939 |
| 38 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.65216488 |
| 39 | protein deneddylation (GO:0000338) | 3.62233479 |
| 40 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.61753670 |
| 41 | oxidative phosphorylation (GO:0006119) | 3.59362612 |
| 42 | cullin deneddylation (GO:0010388) | 3.54725543 |
| 43 | rRNA catabolic process (GO:0016075) | 3.47165690 |
| 44 | positive regulation of ligase activity (GO:0051351) | 3.45302937 |
| 45 | ribosome assembly (GO:0042255) | 3.36779483 |
| 46 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.36389701 |
| 47 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.36389701 |
| 48 | rRNA methylation (GO:0031167) | 3.32194858 |
| 49 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.28525476 |
| 50 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.28525476 |
| 51 | positive regulation of cell cycle arrest (GO:0071158) | 3.28087331 |
| 52 | ribosomal large subunit biogenesis (GO:0042273) | 3.27048336 |
| 53 | cytochrome complex assembly (GO:0017004) | 3.23486389 |
| 54 | respiratory chain complex IV assembly (GO:0008535) | 3.21290166 |
| 55 | DNA damage response, detection of DNA damage (GO:0042769) | 3.18885171 |
| 56 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.17403795 |
| 57 | regulation of thymocyte apoptotic process (GO:0070243) | 3.16853247 |
| 58 | chaperone-mediated protein transport (GO:0072321) | 3.16304964 |
| 59 | hydrogen ion transmembrane transport (GO:1902600) | 3.13156207 |
| 60 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.12322279 |
| 61 | maturation of 5.8S rRNA (GO:0000460) | 3.11660881 |
| 62 | regulation of cellular amine metabolic process (GO:0033238) | 3.11128303 |
| 63 | protein-cofactor linkage (GO:0018065) | 3.08040196 |
| 64 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.06230437 |
| 65 | IMP biosynthetic process (GO:0006188) | 3.04711601 |
| 66 | metallo-sulfur cluster assembly (GO:0031163) | 3.01479852 |
| 67 | iron-sulfur cluster assembly (GO:0016226) | 3.01479852 |
| 68 | organelle disassembly (GO:1903008) | 3.00582902 |
| 69 | ATP biosynthetic process (GO:0006754) | 2.99350721 |
| 70 | regulation of ligase activity (GO:0051340) | 2.97858147 |
| 71 | platelet dense granule organization (GO:0060155) | 2.97806983 |
| 72 | aldehyde catabolic process (GO:0046185) | 2.96872553 |
| 73 | negative regulation of protein ubiquitination (GO:0031397) | 2.94830998 |
| 74 | AMP metabolic process (GO:0046033) | 2.89849256 |
| 75 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.88558034 |
| 76 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.86981345 |
| 77 | kynurenine metabolic process (GO:0070189) | 2.86805061 |
| 78 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.86324162 |
| 79 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.85525115 |
| 80 | hydrogen transport (GO:0006818) | 2.84611007 |
| 81 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.83902149 |
| 82 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.83902149 |
| 83 | proton transport (GO:0015992) | 2.83278398 |
| 84 | mismatch repair (GO:0006298) | 2.82875725 |
| 85 | protein localization to cilium (GO:0061512) | 2.82795175 |
| 86 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.81947690 |
| 87 | negative regulation of cell cycle G1/S phase transition (GO:1902807) | 2.78550919 |
| 88 | negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) | 2.78550919 |
| 89 | behavioral response to nicotine (GO:0035095) | 2.78534675 |
| 90 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.77652822 |
| 91 | replication fork processing (GO:0031297) | 2.77466210 |
| 92 | peptidyl-histidine modification (GO:0018202) | 2.76568608 |
| 93 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.76566383 |
| 94 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.75524506 |
| 95 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.75524506 |
| 96 | DNA replication checkpoint (GO:0000076) | 2.74553399 |
| 97 | chromatin remodeling at centromere (GO:0031055) | 2.74192180 |
| 98 | synapsis (GO:0007129) | 2.74093918 |
| 99 | postreplication repair (GO:0006301) | 2.73627521 |
| 100 | CENP-A containing nucleosome assembly (GO:0034080) | 2.71575856 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.37348720 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.54592389 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.24352886 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.63564996 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.40278329 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.09360280 |
| 7 | VDR_22108803_ChIP-Seq_LS180_Human | 2.98027934 |
| 8 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.96898485 |
| 9 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.69512471 |
| 10 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.64645981 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.63657757 |
| 12 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.61658851 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.52838181 |
| 14 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.46002329 |
| 15 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.43422511 |
| 16 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.31877626 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.30693986 |
| 18 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.18352797 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.17403245 |
| 20 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.12084757 |
| 21 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.07902153 |
| 22 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.02300199 |
| 23 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.94919343 |
| 24 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.93790517 |
| 25 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.92122112 |
| 26 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.91002959 |
| 27 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.89541637 |
| 28 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.86059989 |
| 29 | EWS_26573619_Chip-Seq_HEK293_Human | 1.78207432 |
| 30 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.74069207 |
| 31 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.65706787 |
| 32 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.64001478 |
| 33 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.59674983 |
| 34 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.57192809 |
| 35 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.54217951 |
| 36 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.53895148 |
| 37 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.47600411 |
| 38 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.46617086 |
| 39 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.45610300 |
| 40 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.43438454 |
| 41 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.41396412 |
| 42 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.40455851 |
| 43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.40006606 |
| 44 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.37294056 |
| 45 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.35469932 |
| 46 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.34552722 |
| 47 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.33244073 |
| 48 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.31284741 |
| 49 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.31141576 |
| 50 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.30400158 |
| 51 | FUS_26573619_Chip-Seq_HEK293_Human | 1.29378792 |
| 52 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.28547743 |
| 53 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.28106672 |
| 54 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.26824739 |
| 55 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.24298602 |
| 56 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.24173013 |
| 57 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.22949769 |
| 58 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.22732477 |
| 59 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.18474919 |
| 60 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.17092258 |
| 61 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.16859445 |
| 62 | NCOR_22424771_ChIP-Seq_293T_Human | 1.16748606 |
| 63 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.15939545 |
| 64 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.14496284 |
| 65 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.10978883 |
| 66 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.10674059 |
| 67 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.09484724 |
| 68 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.08760983 |
| 69 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.08303840 |
| 70 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.08291450 |
| 71 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.07819786 |
| 72 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.07734122 |
| 73 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.07520781 |
| 74 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.05997170 |
| 75 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.05798382 |
| 76 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.05122413 |
| 77 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.04357317 |
| 78 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.02070419 |
| 79 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.01957732 |
| 80 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.01238221 |
| 81 | AR_20517297_ChIP-Seq_VCAP_Human | 1.01181269 |
| 82 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.00854354 |
| 83 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.00502123 |
| 84 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.00502123 |
| 85 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.00416763 |
| 86 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.00413036 |
| 87 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.00413036 |
| 88 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.99624947 |
| 89 | P300_19829295_ChIP-Seq_ESCs_Human | 0.97672255 |
| 90 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.96609672 |
| 91 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.95919035 |
| 92 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.93025083 |
| 93 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.91520856 |
| 94 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.90885183 |
| 95 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.89696411 |
| 96 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.89454777 |
| 97 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.86372204 |
| 98 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.86199824 |
| 99 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.86199824 |
| 100 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.85023561 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008875_abnormal_xenobiotic_pharmacok | 3.37307282 |
| 2 | MP0002102_abnormal_ear_morphology | 3.15865615 |
| 3 | MP0008058_abnormal_DNA_repair | 3.14440625 |
| 4 | MP0005084_abnormal_gallbladder_morpholo | 3.14059000 |
| 5 | MP0000372_irregular_coat_pigmentation | 2.97561560 |
| 6 | MP0001984_abnormal_olfaction | 2.68049899 |
| 7 | MP0004885_abnormal_endolymph | 2.63926103 |
| 8 | MP0010094_abnormal_chromosome_stability | 2.50026107 |
| 9 | MP0001529_abnormal_vocalization | 2.43707778 |
| 10 | MP0003806_abnormal_nucleotide_metabolis | 2.30824128 |
| 11 | MP0003880_abnormal_central_pattern | 2.09067693 |
| 12 | MP0006072_abnormal_retinal_apoptosis | 2.07321974 |
| 13 | MP0003252_abnormal_bile_duct | 2.06087267 |
| 14 | MP0003646_muscle_fatigue | 1.87755401 |
| 15 | MP0008872_abnormal_physiological_respon | 1.82364724 |
| 16 | MP0003718_maternal_effect | 1.80853868 |
| 17 | MP0002160_abnormal_reproductive_system | 1.80555546 |
| 18 | MP0003195_calcinosis | 1.76789547 |
| 19 | MP0004957_abnormal_blastocyst_morpholog | 1.76786340 |
| 20 | MP0003786_premature_aging | 1.73805380 |
| 21 | MP0004147_increased_porphyrin_level | 1.71832534 |
| 22 | MP0006036_abnormal_mitochondrial_physio | 1.70412973 |
| 23 | MP0003186_abnormal_redox_activity | 1.68744021 |
| 24 | MP0004145_abnormal_muscle_electrophysio | 1.68012800 |
| 25 | MP0003693_abnormal_embryo_hatching | 1.61216873 |
| 26 | MP0005389_reproductive_system_phenotype | 1.60626771 |
| 27 | MP0005075_abnormal_melanosome_morpholog | 1.55834512 |
| 28 | MP0002938_white_spotting | 1.51722454 |
| 29 | MP0002837_dystrophic_cardiac_calcinosis | 1.49865135 |
| 30 | MP0008877_abnormal_DNA_methylation | 1.46963662 |
| 31 | MP0004133_heterotaxia | 1.42276120 |
| 32 | MP0003111_abnormal_nucleus_morphology | 1.42087259 |
| 33 | MP0001881_abnormal_mammary_gland | 1.40645279 |
| 34 | MP0001485_abnormal_pinna_reflex | 1.38745943 |
| 35 | MP0002006_tumorigenesis | 1.36161721 |
| 36 | MP0005551_abnormal_eye_electrophysiolog | 1.34791577 |
| 37 | MP0002928_abnormal_bile_duct | 1.31196225 |
| 38 | MP0001835_abnormal_antigen_presentation | 1.31127294 |
| 39 | MP0002638_abnormal_pupillary_reflex | 1.29456767 |
| 40 | MP0004142_abnormal_muscle_tone | 1.29314315 |
| 41 | MP0002095_abnormal_skin_pigmentation | 1.28921391 |
| 42 | MP0006035_abnormal_mitochondrial_morpho | 1.25384839 |
| 43 | MP0001293_anophthalmia | 1.24890425 |
| 44 | MP0005187_abnormal_penis_morphology | 1.23929061 |
| 45 | MP0005423_abnormal_somatic_nervous | 1.23249213 |
| 46 | MP0005377_hearing/vestibular/ear_phenot | 1.23069902 |
| 47 | MP0003878_abnormal_ear_physiology | 1.23069902 |
| 48 | MP0010234_abnormal_vibrissa_follicle | 1.16830386 |
| 49 | MP0005671_abnormal_response_to | 1.15843003 |
| 50 | MP0001968_abnormal_touch/_nociception | 1.15517919 |
| 51 | MP0003011_delayed_dark_adaptation | 1.15108553 |
| 52 | MP0010386_abnormal_urinary_bladder | 1.14240492 |
| 53 | MP0005379_endocrine/exocrine_gland_phen | 1.13695230 |
| 54 | MP0006292_abnormal_olfactory_placode | 1.12759763 |
| 55 | MP0006276_abnormal_autonomic_nervous | 1.12755176 |
| 56 | MP0008775_abnormal_heart_ventricle | 1.12583075 |
| 57 | MP0000647_abnormal_sebaceous_gland | 1.11231585 |
| 58 | MP0001905_abnormal_dopamine_level | 1.11000406 |
| 59 | MP0006054_spinal_hemorrhage | 1.07418336 |
| 60 | MP0005253_abnormal_eye_physiology | 1.05982214 |
| 61 | MP0004742_abnormal_vestibular_system | 1.05403039 |
| 62 | MP0009333_abnormal_splenocyte_physiolog | 1.04548839 |
| 63 | MP0002148_abnormal_hypersensitivity_rea | 1.02512066 |
| 64 | MP0002282_abnormal_trachea_morphology | 1.02151868 |
| 65 | MP0002735_abnormal_chemical_nociception | 1.00785031 |
| 66 | MP0005174_abnormal_tail_pigmentation | 1.00230927 |
| 67 | MP0000516_abnormal_urinary_system | 0.97471893 |
| 68 | MP0005367_renal/urinary_system_phenotyp | 0.97471893 |
| 69 | MP0009764_decreased_sensitivity_to | 0.96538808 |
| 70 | MP0001324_abnormal_eye_pigmentation | 0.93075544 |
| 71 | MP0002272_abnormal_nervous_system | 0.92995593 |
| 72 | MP0008995_early_reproductive_senescence | 0.92068386 |
| 73 | MP0000685_abnormal_immune_system | 0.90960962 |
| 74 | MP0002166_altered_tumor_susceptibility | 0.90690601 |
| 75 | MP0009046_muscle_twitch | 0.90679947 |
| 76 | MP0001986_abnormal_taste_sensitivity | 0.88963446 |
| 77 | MP0008007_abnormal_cellular_replicative | 0.88011154 |
| 78 | MP0000538_abnormal_urinary_bladder | 0.87756974 |
| 79 | MP0001929_abnormal_gametogenesis | 0.86891320 |
| 80 | MP0002163_abnormal_gland_morphology | 0.84853339 |
| 81 | MP0003950_abnormal_plasma_membrane | 0.84515803 |
| 82 | MP0003724_increased_susceptibility_to | 0.84122063 |
| 83 | MP0002736_abnormal_nociception_after | 0.83810551 |
| 84 | MP0002210_abnormal_sex_determination | 0.83407339 |
| 85 | MP0005410_abnormal_fertilization | 0.81912002 |
| 86 | MP0000653_abnormal_sex_gland | 0.79334424 |
| 87 | MP0003077_abnormal_cell_cycle | 0.76043724 |
| 88 | MP0008789_abnormal_olfactory_epithelium | 0.75644306 |
| 89 | MP0005408_hypopigmentation | 0.74853227 |
| 90 | MP0005332_abnormal_amino_acid | 0.74549760 |
| 91 | MP0005165_increased_susceptibility_to | 0.73134115 |
| 92 | MP0008932_abnormal_embryonic_tissue | 0.72868710 |
| 93 | MP0001727_abnormal_embryo_implantation | 0.72583299 |
| 94 | MP0003936_abnormal_reproductive_system | 0.72387482 |
| 95 | MP0000015_abnormal_ear_pigmentation | 0.72375447 |
| 96 | MP0001145_abnormal_male_reproductive | 0.71468836 |
| 97 | MP0001970_abnormal_pain_threshold | 0.71145836 |
| 98 | MP0009250_abnormal_appendicular_skeleto | 0.67958917 |
| 99 | MP0001919_abnormal_reproductive_system | 0.67529266 |
| 100 | MP0001790_abnormal_immune_system | 0.67232570 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Mitochondrial inheritance (HP:0001427) | 4.68014480 |
| 2 | Increased CSF lactate (HP:0002490) | 4.63370452 |
| 3 | Acute necrotizing encephalopathy (HP:0006965) | 4.57870052 |
| 4 | Hepatic necrosis (HP:0002605) | 4.53383627 |
| 5 | Hepatocellular necrosis (HP:0001404) | 4.47069225 |
| 6 | Increased hepatocellular lipid droplets (HP:0006565) | 4.45921750 |
| 7 | Lipid accumulation in hepatocytes (HP:0006561) | 4.03157213 |
| 8 | Acute encephalopathy (HP:0006846) | 4.01398727 |
| 9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.95830426 |
| 10 | Progressive macrocephaly (HP:0004481) | 3.93486822 |
| 11 | Renal Fanconi syndrome (HP:0001994) | 3.59140759 |
| 12 | Increased serum lactate (HP:0002151) | 3.35431828 |
| 13 | Cerebral edema (HP:0002181) | 3.27161522 |
| 14 | Exertional dyspnea (HP:0002875) | 3.24974145 |
| 15 | Nephronophthisis (HP:0000090) | 3.07535858 |
| 16 | Increased serum pyruvate (HP:0003542) | 3.03878656 |
| 17 | Generalized aminoaciduria (HP:0002909) | 2.99049759 |
| 18 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.92949483 |
| 19 | Abnormality of urine glucose concentration (HP:0011016) | 2.89156368 |
| 20 | Glycosuria (HP:0003076) | 2.89156368 |
| 21 | Abnormality of the labia minora (HP:0012880) | 2.84846785 |
| 22 | IgM deficiency (HP:0002850) | 2.83842174 |
| 23 | Optic disc pallor (HP:0000543) | 2.82194476 |
| 24 | Lactic acidosis (HP:0003128) | 2.82082753 |
| 25 | Increased intramyocellular lipid droplets (HP:0012240) | 2.78682241 |
| 26 | Respiratory failure (HP:0002878) | 2.67274300 |
| 27 | Abnormality of glycolysis (HP:0004366) | 2.64014000 |
| 28 | Abnormality of the anterior horn cell (HP:0006802) | 2.57899887 |
| 29 | Degeneration of anterior horn cells (HP:0002398) | 2.57899887 |
| 30 | Decreased central vision (HP:0007663) | 2.56108366 |
| 31 | Methylmalonic acidemia (HP:0002912) | 2.53567565 |
| 32 | Hyperglycinemia (HP:0002154) | 2.51088237 |
| 33 | Abnormality of the renal medulla (HP:0100957) | 2.50746536 |
| 34 | Respiratory difficulties (HP:0002880) | 2.50672166 |
| 35 | Colon cancer (HP:0003003) | 2.48201598 |
| 36 | Lethargy (HP:0001254) | 2.44885966 |
| 37 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.44371196 |
| 38 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.44371196 |
| 39 | Renal cortical cysts (HP:0000803) | 2.39056877 |
| 40 | Medial flaring of the eyebrow (HP:0010747) | 2.38646572 |
| 41 | Exercise intolerance (HP:0003546) | 2.36739512 |
| 42 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.33559083 |
| 43 | Methylmalonic aciduria (HP:0012120) | 2.31493442 |
| 44 | CNS demyelination (HP:0007305) | 2.30344534 |
| 45 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.23878441 |
| 46 | Abnormality of glycine metabolism (HP:0010895) | 2.20753058 |
| 47 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.20753058 |
| 48 | Ependymoma (HP:0002888) | 2.20633350 |
| 49 | Abnormality of the vocal cords (HP:0008777) | 2.19864048 |
| 50 | Attenuation of retinal blood vessels (HP:0007843) | 2.19357134 |
| 51 | Nausea (HP:0002018) | 2.18731710 |
| 52 | Cerebral hypomyelination (HP:0006808) | 2.18450162 |
| 53 | Increased muscle lipid content (HP:0009058) | 2.18435271 |
| 54 | Abnormality of serum amino acid levels (HP:0003112) | 2.16268190 |
| 55 | Abnormality of the renal cortex (HP:0011035) | 2.15200881 |
| 56 | Congenital stationary night blindness (HP:0007642) | 2.10859105 |
| 57 | Abnormality of renal resorption (HP:0011038) | 2.09736445 |
| 58 | IgG deficiency (HP:0004315) | 2.09065809 |
| 59 | Abolished electroretinogram (ERG) (HP:0000550) | 2.08532374 |
| 60 | Abnormality of midbrain morphology (HP:0002418) | 2.04952623 |
| 61 | Molar tooth sign on MRI (HP:0002419) | 2.04952623 |
| 62 | Supernumerary spleens (HP:0009799) | 2.04061056 |
| 63 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.02258912 |
| 64 | Congenital, generalized hypertrichosis (HP:0004540) | 2.00697187 |
| 65 | Hypoglycemic coma (HP:0001325) | 2.00450096 |
| 66 | Hypoplasia of the uterus (HP:0000013) | 1.97820437 |
| 67 | Pancytopenia (HP:0001876) | 1.95099956 |
| 68 | Stomatitis (HP:0010280) | 1.95013557 |
| 69 | Hyperphosphaturia (HP:0003109) | 1.94008855 |
| 70 | Pancreatic cysts (HP:0001737) | 1.91656668 |
| 71 | Hyperglycinuria (HP:0003108) | 1.90829321 |
| 72 | Leukodystrophy (HP:0002415) | 1.90176692 |
| 73 | Type I transferrin isoform profile (HP:0003642) | 1.89667922 |
| 74 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.89367923 |
| 75 | Abnormality of alanine metabolism (HP:0010916) | 1.89367923 |
| 76 | Hyperalaninemia (HP:0003348) | 1.89367923 |
| 77 | Abnormality of B cell number (HP:0010975) | 1.87671264 |
| 78 | Type II lissencephaly (HP:0007260) | 1.85202857 |
| 79 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.84625206 |
| 80 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.84625206 |
| 81 | Abnormal protein glycosylation (HP:0012346) | 1.84625206 |
| 82 | Abnormal glycosylation (HP:0012345) | 1.84625206 |
| 83 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.84179652 |
| 84 | Pendular nystagmus (HP:0012043) | 1.81076336 |
| 85 | Gonadotropin excess (HP:0000837) | 1.78238451 |
| 86 | Opisthotonus (HP:0002179) | 1.76475942 |
| 87 | Abnormality of T cell physiology (HP:0011840) | 1.75949871 |
| 88 | Neuroendocrine neoplasm (HP:0100634) | 1.75440673 |
| 89 | Gliosis (HP:0002171) | 1.72866431 |
| 90 | Hypothermia (HP:0002045) | 1.72711904 |
| 91 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.71982859 |
| 92 | Azoospermia (HP:0000027) | 1.71805866 |
| 93 | Emotional lability (HP:0000712) | 1.70281926 |
| 94 | Hypomagnesemia (HP:0002917) | 1.70148708 |
| 95 | Ketosis (HP:0001946) | 1.69294877 |
| 96 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.69184558 |
| 97 | Neutropenia (HP:0001875) | 1.67699075 |
| 98 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.65224181 |
| 99 | Dicarboxylic aciduria (HP:0003215) | 1.65224181 |
| 100 | Pachygyria (HP:0001302) | 1.65033171 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EIF2AK3 | 4.18724105 |
| 2 | VRK2 | 3.63752372 |
| 3 | ZAK | 3.49975614 |
| 4 | TLK1 | 3.15996209 |
| 5 | BUB1 | 3.06873421 |
| 6 | EIF2AK1 | 2.98675702 |
| 7 | NUAK1 | 2.94276294 |
| 8 | TAF1 | 2.55507498 |
| 9 | TSSK6 | 2.47504402 |
| 10 | TRIM28 | 2.31896063 |
| 11 | MST4 | 2.10128564 |
| 12 | VRK1 | 2.06591500 |
| 13 | PLK3 | 2.01396556 |
| 14 | FRK | 1.84368594 |
| 15 | PDK2 | 1.79380337 |
| 16 | NEK1 | 1.77555757 |
| 17 | BMPR1B | 1.70074556 |
| 18 | BCKDK | 1.62682385 |
| 19 | MKNK2 | 1.62312241 |
| 20 | MKNK1 | 1.59609822 |
| 21 | TAOK3 | 1.55607166 |
| 22 | EIF2AK2 | 1.50215734 |
| 23 | ADRBK2 | 1.47746046 |
| 24 | WNK4 | 1.46636227 |
| 25 | SRPK1 | 1.42572325 |
| 26 | PLK2 | 1.41560261 |
| 27 | OXSR1 | 1.29186550 |
| 28 | PBK | 1.25215089 |
| 29 | PHKG2 | 1.23115211 |
| 30 | PHKG1 | 1.23115211 |
| 31 | STK39 | 1.17091341 |
| 32 | PLK4 | 1.14761017 |
| 33 | STK16 | 1.14624555 |
| 34 | MAP3K14 | 1.13403065 |
| 35 | GRK1 | 1.12802805 |
| 36 | NME1 | 1.07762320 |
| 37 | GRK5 | 1.06371483 |
| 38 | DYRK2 | 1.05124288 |
| 39 | TTK | 1.04541362 |
| 40 | CSNK1G3 | 1.02884164 |
| 41 | KIT | 0.98713764 |
| 42 | PASK | 0.98127893 |
| 43 | CDK8 | 0.94181343 |
| 44 | CSNK1G1 | 0.93602489 |
| 45 | INSRR | 0.89822805 |
| 46 | TEC | 0.87954137 |
| 47 | WNK3 | 0.87790666 |
| 48 | MAP4K2 | 0.86990397 |
| 49 | TXK | 0.85256799 |
| 50 | PINK1 | 0.85181875 |
| 51 | MAP2K7 | 0.84700041 |
| 52 | TGFBR1 | 0.84317525 |
| 53 | STK24 | 0.82437469 |
| 54 | CSNK1G2 | 0.81741443 |
| 55 | ILK | 0.81066758 |
| 56 | PLK1 | 0.78395785 |
| 57 | SYK | 0.75870629 |
| 58 | ATR | 0.75459815 |
| 59 | ERBB3 | 0.75410000 |
| 60 | CSNK1A1L | 0.73219133 |
| 61 | ALK | 0.72801496 |
| 62 | MAPKAPK5 | 0.71931929 |
| 63 | CAMKK1 | 0.70976439 |
| 64 | CDC7 | 0.66759670 |
| 65 | DAPK1 | 0.65828594 |
| 66 | FES | 0.61115892 |
| 67 | BCR | 0.59225459 |
| 68 | TIE1 | 0.58392896 |
| 69 | CCNB1 | 0.56737076 |
| 70 | PRKCQ | 0.56086543 |
| 71 | TNIK | 0.55157834 |
| 72 | PRKCG | 0.55009019 |
| 73 | ADRBK1 | 0.53467561 |
| 74 | BRSK1 | 0.52818087 |
| 75 | PNCK | 0.52222442 |
| 76 | PIM2 | 0.51326997 |
| 77 | GRK6 | 0.50967040 |
| 78 | MAP3K12 | 0.50249622 |
| 79 | RPS6KA5 | 0.48767780 |
| 80 | CHEK2 | 0.47884887 |
| 81 | AURKB | 0.46964571 |
| 82 | MAP3K4 | 0.46801862 |
| 83 | ITK | 0.46497269 |
| 84 | WEE1 | 0.45070286 |
| 85 | AURKA | 0.42920666 |
| 86 | PRKCI | 0.42573792 |
| 87 | FGFR2 | 0.41241543 |
| 88 | ATM | 0.40569684 |
| 89 | CSNK2A1 | 0.40187668 |
| 90 | MAPK13 | 0.39757720 |
| 91 | MYLK | 0.35055805 |
| 92 | DAPK3 | 0.35013565 |
| 93 | EPHA3 | 0.34140961 |
| 94 | PRKCE | 0.33251862 |
| 95 | CDK3 | 0.32345083 |
| 96 | PRKCA | 0.30029727 |
| 97 | CSNK2A2 | 0.29733452 |
| 98 | DYRK1A | 0.28919135 |
| 99 | MAPKAPK3 | 0.28784296 |
| 100 | ACVR1B | 0.28201682 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.29756897 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.51618496 |
| 3 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.26663484 |
| 4 | Protein export_Homo sapiens_hsa03060 | 3.13898282 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.13506814 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.35818188 |
| 7 | Asthma_Homo sapiens_hsa05310 | 2.35817533 |
| 8 | Ribosome_Homo sapiens_hsa03010 | 2.27007763 |
| 9 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.04117051 |
| 10 | Mismatch repair_Homo sapiens_hsa03430 | 1.99185455 |
| 11 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.91339689 |
| 12 | Alzheimers disease_Homo sapiens_hsa05010 | 1.90589233 |
| 13 | Huntingtons disease_Homo sapiens_hsa05016 | 1.90268404 |
| 14 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.77105393 |
| 15 | DNA replication_Homo sapiens_hsa03030 | 1.76254198 |
| 16 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.73352050 |
| 17 | RNA polymerase_Homo sapiens_hsa03020 | 1.64060717 |
| 18 | Allograft rejection_Homo sapiens_hsa05330 | 1.62092708 |
| 19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.61613815 |
| 20 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.59981876 |
| 21 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.58005188 |
| 22 | Homologous recombination_Homo sapiens_hsa03440 | 1.51650484 |
| 23 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.50236162 |
| 24 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.49360493 |
| 25 | Basal transcription factors_Homo sapiens_hsa03022 | 1.47719619 |
| 26 | RNA degradation_Homo sapiens_hsa03018 | 1.46926985 |
| 27 | Base excision repair_Homo sapiens_hsa03410 | 1.42299666 |
| 28 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.38453749 |
| 29 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.35813669 |
| 30 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.35358082 |
| 31 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.34149694 |
| 32 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.31790711 |
| 33 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.28651750 |
| 34 | Phototransduction_Homo sapiens_hsa04744 | 1.22230861 |
| 35 | Spliceosome_Homo sapiens_hsa03040 | 1.21595794 |
| 36 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.18966713 |
| 37 | Purine metabolism_Homo sapiens_hsa00230 | 1.13809158 |
| 38 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.10573790 |
| 39 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.10226980 |
| 40 | RNA transport_Homo sapiens_hsa03013 | 1.09721681 |
| 41 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.05613256 |
| 42 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.99669798 |
| 43 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.96853141 |
| 44 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.96422080 |
| 45 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.95011645 |
| 46 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.94179687 |
| 47 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.92281015 |
| 48 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.89936650 |
| 49 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.89808678 |
| 50 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.84393764 |
| 51 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.83518407 |
| 52 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.83217364 |
| 53 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.79885281 |
| 54 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.79878507 |
| 55 | Peroxisome_Homo sapiens_hsa04146 | 0.78586535 |
| 56 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.77398664 |
| 57 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.74540735 |
| 58 | Sulfur relay system_Homo sapiens_hsa04122 | 0.72231319 |
| 59 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.71515703 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.70605505 |
| 61 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.67808463 |
| 62 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.65399585 |
| 63 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.63441434 |
| 64 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.60870649 |
| 65 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.60248302 |
| 66 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.58897310 |
| 67 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.58045286 |
| 68 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.57345529 |
| 69 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.56620214 |
| 70 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.56553193 |
| 71 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.56172388 |
| 72 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.54391309 |
| 73 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.52633801 |
| 74 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.50622349 |
| 75 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.50086474 |
| 76 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.49333395 |
| 77 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.47503484 |
| 78 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.46215464 |
| 79 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.45937822 |
| 80 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.44573056 |
| 81 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.44554033 |
| 82 | Olfactory transduction_Homo sapiens_hsa04740 | 0.43245024 |
| 83 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.42954855 |
| 84 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.41809857 |
| 85 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.40803981 |
| 86 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.39345977 |
| 87 | Carbon metabolism_Homo sapiens_hsa01200 | 0.38154891 |
| 88 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.36972202 |
| 89 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.36085866 |
| 90 | Morphine addiction_Homo sapiens_hsa05032 | 0.34618449 |
| 91 | Cell cycle_Homo sapiens_hsa04110 | 0.34096491 |
| 92 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.33561627 |
| 93 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.33488028 |
| 94 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.32981176 |
| 95 | Viral myocarditis_Homo sapiens_hsa05416 | 0.32773161 |
| 96 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.31200273 |
| 97 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.30930204 |
| 98 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.30579423 |
| 99 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.29831592 |
| 100 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.29350132 |

