

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | water-soluble vitamin biosynthetic process (GO:0042364) | 6.35466934 |
| 2 | DNA deamination (GO:0045006) | 6.25903936 |
| 3 | proteasome assembly (GO:0043248) | 5.40912176 |
| 4 | respiratory chain complex IV assembly (GO:0008535) | 4.86717714 |
| 5 | cytochrome complex assembly (GO:0017004) | 4.46856829 |
| 6 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.19607031 |
| 7 | ATP synthesis coupled proton transport (GO:0015986) | 4.19607031 |
| 8 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.15169304 |
| 9 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.93038063 |
| 10 | termination of RNA polymerase III transcription (GO:0006386) | 3.93038063 |
| 11 | rRNA modification (GO:0000154) | 3.88860622 |
| 12 | signal peptide processing (GO:0006465) | 3.86771573 |
| 13 | protein complex biogenesis (GO:0070271) | 3.79894877 |
| 14 | kynurenine metabolic process (GO:0070189) | 3.79714392 |
| 15 | cullin deneddylation (GO:0010388) | 3.77313156 |
| 16 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.76174792 |
| 17 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.69622654 |
| 18 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.67621061 |
| 19 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.65658360 |
| 20 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.65658360 |
| 21 | isotype switching (GO:0045190) | 3.65658360 |
| 22 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.63100673 |
| 23 | NADH dehydrogenase complex assembly (GO:0010257) | 3.63100673 |
| 24 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.63100673 |
| 25 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.62378250 |
| 26 | protein deneddylation (GO:0000338) | 3.61433186 |
| 27 | DNA damage response, detection of DNA damage (GO:0042769) | 3.60057363 |
| 28 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.58240673 |
| 29 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.57202087 |
| 30 | DNA double-strand break processing (GO:0000729) | 3.56597128 |
| 31 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.49457526 |
| 32 | tryptophan catabolic process (GO:0006569) | 3.45418450 |
| 33 | indole-containing compound catabolic process (GO:0042436) | 3.45418450 |
| 34 | indolalkylamine catabolic process (GO:0046218) | 3.45418450 |
| 35 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.45270570 |
| 36 | rRNA methylation (GO:0031167) | 3.40244266 |
| 37 | vitamin biosynthetic process (GO:0009110) | 3.38391347 |
| 38 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.36774538 |
| 39 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.33671067 |
| 40 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.32699454 |
| 41 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.32699454 |
| 42 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.32699454 |
| 43 | response to pheromone (GO:0019236) | 3.30375629 |
| 44 | pseudouridine synthesis (GO:0001522) | 3.28744597 |
| 45 | piRNA metabolic process (GO:0034587) | 3.27951875 |
| 46 | cytidine metabolic process (GO:0046087) | 3.26974361 |
| 47 | cytidine catabolic process (GO:0006216) | 3.26974361 |
| 48 | cytidine deamination (GO:0009972) | 3.26974361 |
| 49 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.26633914 |
| 50 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.26633914 |
| 51 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.23697546 |
| 52 | aldehyde catabolic process (GO:0046185) | 3.21068531 |
| 53 | tryptophan metabolic process (GO:0006568) | 3.18610772 |
| 54 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.12732933 |
| 55 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.12732933 |
| 56 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.12444542 |
| 57 | ribosome assembly (GO:0042255) | 3.09083765 |
| 58 | non-recombinational repair (GO:0000726) | 3.06738336 |
| 59 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.06738336 |
| 60 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.06734759 |
| 61 | positive regulation of prostaglandin secretion (GO:0032308) | 3.05811111 |
| 62 | protein neddylation (GO:0045116) | 3.04092909 |
| 63 | negative regulation of ligase activity (GO:0051352) | 3.02937706 |
| 64 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.02937706 |
| 65 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.99868392 |
| 66 | indolalkylamine metabolic process (GO:0006586) | 2.99635094 |
| 67 | negative regulation of T cell differentiation in thymus (GO:0033085) | 2.96873482 |
| 68 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.95981669 |
| 69 | synapsis (GO:0007129) | 2.95061437 |
| 70 | chromatin remodeling at centromere (GO:0031055) | 2.89509353 |
| 71 | chaperone-mediated protein transport (GO:0072321) | 2.88633506 |
| 72 | respiratory electron transport chain (GO:0022904) | 2.88123028 |
| 73 | electron transport chain (GO:0022900) | 2.87087884 |
| 74 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.82887297 |
| 75 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.82887297 |
| 76 | CENP-A containing nucleosome assembly (GO:0034080) | 2.80783311 |
| 77 | histone exchange (GO:0043486) | 2.80655867 |
| 78 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.78202407 |
| 79 | GTP biosynthetic process (GO:0006183) | 2.77417025 |
| 80 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.76192060 |
| 81 | organelle disassembly (GO:1903008) | 2.71735358 |
| 82 | positive regulation of ligase activity (GO:0051351) | 2.70504574 |
| 83 | amino acid salvage (GO:0043102) | 2.69310438 |
| 84 | L-methionine salvage (GO:0071267) | 2.69310438 |
| 85 | L-methionine biosynthetic process (GO:0071265) | 2.69310438 |
| 86 | somatic diversification of immunoglobulins (GO:0016445) | 2.68726833 |
| 87 | AMP metabolic process (GO:0046033) | 2.67629531 |
| 88 | DNA ligation (GO:0006266) | 2.66121985 |
| 89 | regulation of cellular amine metabolic process (GO:0033238) | 2.65500339 |
| 90 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 2.65455305 |
| 91 | phosphatidylinositol acyl-chain remodeling (GO:0036149) | 2.63535512 |
| 92 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.60788968 |
| 93 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.60704829 |
| 94 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.60009840 |
| 95 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.60009840 |
| 96 | regulation of oxidative phosphorylation (GO:0002082) | 2.57324577 |
| 97 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.57102231 |
| 98 | iron-sulfur cluster assembly (GO:0016226) | 2.56606299 |
| 99 | metallo-sulfur cluster assembly (GO:0031163) | 2.56606299 |
| 100 | maturation of 5.8S rRNA (GO:0000460) | 2.55512907 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.01357286 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.47386510 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.17590169 |
| 4 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.62092780 |
| 5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.40819425 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.08262710 |
| 7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.05689743 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.92031983 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.76358002 |
| 10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.48251456 |
| 11 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.46245477 |
| 12 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.40996910 |
| 13 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.33674940 |
| 14 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.31946310 |
| 15 | VDR_22108803_ChIP-Seq_LS180_Human | 2.31911254 |
| 16 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.31267658 |
| 17 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.29570060 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.22091136 |
| 19 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.21192739 |
| 20 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.04479669 |
| 21 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.00525165 |
| 22 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.97370084 |
| 23 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.92493932 |
| 24 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.77510198 |
| 25 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.75513219 |
| 26 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.73749856 |
| 27 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.70513036 |
| 28 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.61151421 |
| 29 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.60391307 |
| 30 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.58620286 |
| 31 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.52626090 |
| 32 | EWS_26573619_Chip-Seq_HEK293_Human | 1.52378103 |
| 33 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.52325022 |
| 34 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.51677385 |
| 35 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.49697672 |
| 36 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.47944611 |
| 37 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.47692471 |
| 38 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.46574209 |
| 39 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.41776816 |
| 40 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.39397173 |
| 41 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.39389966 |
| 42 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.38260153 |
| 43 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.37848747 |
| 44 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.36450959 |
| 45 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.33568917 |
| 46 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.32864842 |
| 47 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.30380675 |
| 48 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.28902458 |
| 49 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.26752909 |
| 50 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.26368746 |
| 51 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.23496459 |
| 52 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.21409656 |
| 53 | AR_20517297_ChIP-Seq_VCAP_Human | 1.20734682 |
| 54 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.19382964 |
| 55 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.17770687 |
| 56 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.17770687 |
| 57 | GATA3_26560356_Chip-Seq_TH2_Human | 1.16006144 |
| 58 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.12522991 |
| 59 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.11167367 |
| 60 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.11158968 |
| 61 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.10841698 |
| 62 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.10249453 |
| 63 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.10069528 |
| 64 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.10055810 |
| 65 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.10055810 |
| 66 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.09139681 |
| 67 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.08035614 |
| 68 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.07580875 |
| 69 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.07320219 |
| 70 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.06865277 |
| 71 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.06619456 |
| 72 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.05900596 |
| 73 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.05838750 |
| 74 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.03834960 |
| 75 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.03171757 |
| 76 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.02677397 |
| 77 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.02615206 |
| 78 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.01954214 |
| 79 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.00887584 |
| 80 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 0.99374736 |
| 81 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.99175486 |
| 82 | NCOR_22424771_ChIP-Seq_293T_Human | 0.99042479 |
| 83 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.97668211 |
| 84 | E2F7_22180533_ChIP-Seq_HELA_Human | 0.96046218 |
| 85 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.95967946 |
| 86 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.93998253 |
| 87 | P300_19829295_ChIP-Seq_ESCs_Human | 0.91647538 |
| 88 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.91439754 |
| 89 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.91360942 |
| 90 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.89554715 |
| 91 | FUS_26573619_Chip-Seq_HEK293_Human | 0.88837681 |
| 92 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.88336946 |
| 93 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.88148699 |
| 94 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.87006076 |
| 95 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.85463321 |
| 96 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.85455114 |
| 97 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.85435492 |
| 98 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.84930987 |
| 99 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84215402 |
| 100 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.84033738 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008875_abnormal_xenobiotic_pharmacok | 3.51308163 |
| 2 | MP0003646_muscle_fatigue | 3.34544695 |
| 3 | MP0000372_irregular_coat_pigmentation | 3.31539683 |
| 4 | MP0002102_abnormal_ear_morphology | 3.19652695 |
| 5 | MP0003806_abnormal_nucleotide_metabolis | 3.10607774 |
| 6 | MP0003195_calcinosis | 2.91371549 |
| 7 | MP0002138_abnormal_hepatobiliary_system | 2.63840441 |
| 8 | MP0008058_abnormal_DNA_repair | 2.57587571 |
| 9 | MP0006036_abnormal_mitochondrial_physio | 2.52386474 |
| 10 | MP0003693_abnormal_embryo_hatching | 2.33762624 |
| 11 | MP0008872_abnormal_physiological_respon | 2.32985507 |
| 12 | MP0010094_abnormal_chromosome_stability | 2.24926782 |
| 13 | MP0005671_abnormal_response_to | 2.11710145 |
| 14 | MP0002006_tumorigenesis | 2.10288295 |
| 15 | MP0008877_abnormal_DNA_methylation | 2.01455205 |
| 16 | MP0002166_altered_tumor_susceptibility | 2.00025698 |
| 17 | MP0000685_abnormal_immune_system | 1.96817023 |
| 18 | MP0004147_increased_porphyrin_level | 1.95190789 |
| 19 | MP0004957_abnormal_blastocyst_morpholog | 1.91798965 |
| 20 | MP0009333_abnormal_splenocyte_physiolog | 1.82365920 |
| 21 | MP0004885_abnormal_endolymph | 1.81280620 |
| 22 | MP0005075_abnormal_melanosome_morpholog | 1.80169449 |
| 23 | MP0001348_abnormal_lacrimal_gland | 1.77133241 |
| 24 | MP0005360_urolithiasis | 1.69747725 |
| 25 | MP0005084_abnormal_gallbladder_morpholo | 1.69064317 |
| 26 | MP0001835_abnormal_antigen_presentation | 1.60865906 |
| 27 | MP0003567_abnormal_fetal_cardiomyocyte | 1.59493710 |
| 28 | MP0001661_extended_life_span | 1.58727786 |
| 29 | MP0006035_abnormal_mitochondrial_morpho | 1.55941010 |
| 30 | MP0002736_abnormal_nociception_after | 1.54908557 |
| 31 | MP0005379_endocrine/exocrine_gland_phen | 1.54523855 |
| 32 | MP0005646_abnormal_pituitary_gland | 1.53853442 |
| 33 | MP0001968_abnormal_touch/_nociception | 1.52636291 |
| 34 | MP0009697_abnormal_copulation | 1.51876036 |
| 35 | MP0005085_abnormal_gallbladder_physiolo | 1.48011877 |
| 36 | MP0005167_abnormal_blood-brain_barrier | 1.40368391 |
| 37 | MP0006072_abnormal_retinal_apoptosis | 1.38083764 |
| 38 | MP0003186_abnormal_redox_activity | 1.35990869 |
| 39 | MP0003786_premature_aging | 1.35558483 |
| 40 | MP0002876_abnormal_thyroid_physiology | 1.35487420 |
| 41 | MP0009046_muscle_twitch | 1.34272838 |
| 42 | MP0002148_abnormal_hypersensitivity_rea | 1.31682632 |
| 43 | MP0001485_abnormal_pinna_reflex | 1.31185371 |
| 44 | MP0010386_abnormal_urinary_bladder | 1.29787916 |
| 45 | MP0001986_abnormal_taste_sensitivity | 1.29269424 |
| 46 | MP0002163_abnormal_gland_morphology | 1.28764080 |
| 47 | MP0003718_maternal_effect | 1.28454270 |
| 48 | MP0001764_abnormal_homeostasis | 1.27382266 |
| 49 | MP0005332_abnormal_amino_acid | 1.26650691 |
| 50 | MP0004742_abnormal_vestibular_system | 1.24452542 |
| 51 | MP0005408_hypopigmentation | 1.24230739 |
| 52 | MP0001800_abnormal_humoral_immune | 1.23422186 |
| 53 | MP0002095_abnormal_skin_pigmentation | 1.20469328 |
| 54 | MP0004145_abnormal_muscle_electrophysio | 1.19524789 |
| 55 | MP0005387_immune_system_phenotype | 1.16626724 |
| 56 | MP0001790_abnormal_immune_system | 1.16626724 |
| 57 | MP0005636_abnormal_mineral_homeostasis | 1.12727777 |
| 58 | MP0003111_abnormal_nucleus_morphology | 1.12425509 |
| 59 | MP0000613_abnormal_salivary_gland | 1.11960399 |
| 60 | MP0003866_abnormal_defecation | 1.10641374 |
| 61 | MP0003950_abnormal_plasma_membrane | 1.08276094 |
| 62 | MP0005083_abnormal_biliary_tract | 1.08184569 |
| 63 | MP0006054_spinal_hemorrhage | 1.05891044 |
| 64 | MP0008007_abnormal_cellular_replicative | 1.05877386 |
| 65 | MP0005174_abnormal_tail_pigmentation | 1.00763832 |
| 66 | MP0005171_absent_coat_pigmentation | 0.98205595 |
| 67 | MP0005389_reproductive_system_phenotype | 0.97829934 |
| 68 | MP0002272_abnormal_nervous_system | 0.97645583 |
| 69 | MP0000015_abnormal_ear_pigmentation | 0.92243569 |
| 70 | MP0005367_renal/urinary_system_phenotyp | 0.90694620 |
| 71 | MP0000516_abnormal_urinary_system | 0.90694620 |
| 72 | MP0006082_CNS_inflammation | 0.90126156 |
| 73 | MP0005551_abnormal_eye_electrophysiolog | 0.87589540 |
| 74 | MP0001929_abnormal_gametogenesis | 0.85721236 |
| 75 | MP0005253_abnormal_eye_physiology | 0.85259386 |
| 76 | MP0003252_abnormal_bile_duct | 0.83604265 |
| 77 | MP0001873_stomach_inflammation | 0.81882244 |
| 78 | MP0005310_abnormal_salivary_gland | 0.81035892 |
| 79 | MP0002277_abnormal_respiratory_mucosa | 0.80813457 |
| 80 | MP0002837_dystrophic_cardiac_calcinosis | 0.80763612 |
| 81 | MP0002693_abnormal_pancreas_physiology | 0.80253498 |
| 82 | MP0005645_abnormal_hypothalamus_physiol | 0.79644649 |
| 83 | MP0000427_abnormal_hair_cycle | 0.79182665 |
| 84 | MP0001756_abnormal_urination | 0.78599613 |
| 85 | MP0004215_abnormal_myocardial_fiber | 0.76969007 |
| 86 | MP0001919_abnormal_reproductive_system | 0.76604978 |
| 87 | MP0002723_abnormal_immune_serum | 0.76095361 |
| 88 | MP0009785_altered_susceptibility_to | 0.75844399 |
| 89 | MP0000689_abnormal_spleen_morphology | 0.74995291 |
| 90 | MP0002452_abnormal_antigen_presenting | 0.74160125 |
| 91 | MP0004381_abnormal_hair_follicle | 0.72791629 |
| 92 | MP0005000_abnormal_immune_tolerance | 0.72583105 |
| 93 | MP0009643_abnormal_urine_homeostasis | 0.72428935 |
| 94 | MP0003878_abnormal_ear_physiology | 0.72284124 |
| 95 | MP0005377_hearing/vestibular/ear_phenot | 0.72284124 |
| 96 | MP0005365_abnormal_bile_salt | 0.70614265 |
| 97 | MP0008873_increased_physiological_sensi | 0.70346113 |
| 98 | MP0002420_abnormal_adaptive_immunity | 0.68903308 |
| 99 | MP0005319_abnormal_enzyme/_coenzyme | 0.68525054 |
| 100 | MP0001819_abnormal_immune_cell | 0.68269958 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased CSF lactate (HP:0002490) | 4.14375125 |
| 2 | Mitochondrial inheritance (HP:0001427) | 3.97813013 |
| 3 | Hepatocellular necrosis (HP:0001404) | 3.93153820 |
| 4 | Hepatic necrosis (HP:0002605) | 3.91202713 |
| 5 | Acute necrotizing encephalopathy (HP:0006965) | 3.82823882 |
| 6 | Increased hepatocellular lipid droplets (HP:0006565) | 3.74317876 |
| 7 | Progressive macrocephaly (HP:0004481) | 3.57630253 |
| 8 | Acute encephalopathy (HP:0006846) | 3.41475996 |
| 9 | Methylmalonic acidemia (HP:0002912) | 3.31828588 |
| 10 | Lipid accumulation in hepatocytes (HP:0006561) | 3.28158736 |
| 11 | Increased serum lactate (HP:0002151) | 3.23397671 |
| 12 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.22270399 |
| 13 | Methylmalonic aciduria (HP:0012120) | 3.01013870 |
| 14 | Colon cancer (HP:0003003) | 2.98595704 |
| 15 | Cerebral edema (HP:0002181) | 2.87343293 |
| 16 | Renal Fanconi syndrome (HP:0001994) | 2.85600993 |
| 17 | Abnormality of the labia minora (HP:0012880) | 2.79636050 |
| 18 | 3-Methylglutaconic aciduria (HP:0003535) | 2.75866667 |
| 19 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.67408255 |
| 20 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.66377328 |
| 21 | Lactic acidosis (HP:0003128) | 2.63242346 |
| 22 | Large for gestational age (HP:0001520) | 2.61353763 |
| 23 | Abnormality of urine glucose concentration (HP:0011016) | 2.60927211 |
| 24 | Glycosuria (HP:0003076) | 2.60927211 |
| 25 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.60183226 |
| 26 | Hypothermia (HP:0002045) | 2.59228011 |
| 27 | Hyperglycinemia (HP:0002154) | 2.54896841 |
| 28 | Lethargy (HP:0001254) | 2.54431076 |
| 29 | Conjunctival hamartoma (HP:0100780) | 2.49253719 |
| 30 | Exertional dyspnea (HP:0002875) | 2.48482835 |
| 31 | Congenital stationary night blindness (HP:0007642) | 2.45646499 |
| 32 | Abnormality of glycine metabolism (HP:0010895) | 2.35314724 |
| 33 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.35314724 |
| 34 | Abnormality of methionine metabolism (HP:0010901) | 2.32673440 |
| 35 | Respiratory difficulties (HP:0002880) | 2.32604778 |
| 36 | IgG deficiency (HP:0004315) | 2.32375717 |
| 37 | Type I transferrin isoform profile (HP:0003642) | 2.32249714 |
| 38 | Respiratory failure (HP:0002878) | 2.32084184 |
| 39 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.29068310 |
| 40 | Optic disc pallor (HP:0000543) | 2.26961116 |
| 41 | Abnormality of B cell number (HP:0010975) | 2.26343352 |
| 42 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.26095494 |
| 43 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.23704845 |
| 44 | Duplicated collecting system (HP:0000081) | 2.23622625 |
| 45 | Abnormality of the renal collecting system (HP:0004742) | 2.22083583 |
| 46 | Neoplasm of the adrenal gland (HP:0100631) | 2.22077719 |
| 47 | Abolished electroretinogram (ERG) (HP:0000550) | 2.21264612 |
| 48 | Abnormality of serum amino acid levels (HP:0003112) | 2.21194816 |
| 49 | Congenital, generalized hypertrichosis (HP:0004540) | 2.18162245 |
| 50 | Abnormality of vitamin B metabolism (HP:0004340) | 2.15391108 |
| 51 | Increased intramyocellular lipid droplets (HP:0012240) | 2.11238046 |
| 52 | Pancytopenia (HP:0001876) | 2.09844787 |
| 53 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.09188096 |
| 54 | Ketoacidosis (HP:0001993) | 2.07772439 |
| 55 | Adrenal hypoplasia (HP:0000835) | 2.07000306 |
| 56 | Palpitations (HP:0001962) | 2.06919618 |
| 57 | Hypoproteinemia (HP:0003075) | 2.06827079 |
| 58 | Ketosis (HP:0001946) | 2.06566318 |
| 59 | B lymphocytopenia (HP:0010976) | 2.05288141 |
| 60 | CNS demyelination (HP:0007305) | 2.04806855 |
| 61 | Molar tooth sign on MRI (HP:0002419) | 2.03405491 |
| 62 | Abnormality of midbrain morphology (HP:0002418) | 2.03405491 |
| 63 | Hyperglycinuria (HP:0003108) | 2.02825524 |
| 64 | Pancreatic cysts (HP:0001737) | 2.02488631 |
| 65 | Supernumerary spleens (HP:0009799) | 2.02375304 |
| 66 | Exercise intolerance (HP:0003546) | 2.01106033 |
| 67 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.01031239 |
| 68 | Cerebral hypomyelination (HP:0006808) | 2.00958791 |
| 69 | Renal cortical cysts (HP:0000803) | 2.00444176 |
| 70 | Abnormality of the renal cortex (HP:0011035) | 1.99609852 |
| 71 | Abnormality of T cell physiology (HP:0011840) | 1.96636454 |
| 72 | Hypoglycemic coma (HP:0001325) | 1.96156977 |
| 73 | Generalized aminoaciduria (HP:0002909) | 1.95136316 |
| 74 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.89703334 |
| 75 | Abnormality of alanine metabolism (HP:0010916) | 1.89703334 |
| 76 | Hyperalaninemia (HP:0003348) | 1.89703334 |
| 77 | IgM deficiency (HP:0002850) | 1.89610100 |
| 78 | Ependymoma (HP:0002888) | 1.84901139 |
| 79 | Stillbirth (HP:0003826) | 1.83608384 |
| 80 | Decreased central vision (HP:0007663) | 1.80190839 |
| 81 | Autoimmune hemolytic anemia (HP:0001890) | 1.79589214 |
| 82 | Hypomagnesemia (HP:0002917) | 1.79181940 |
| 83 | Leukodystrophy (HP:0002415) | 1.78153468 |
| 84 | Increased serum pyruvate (HP:0003542) | 1.77824035 |
| 85 | Neoplasm of the adrenal cortex (HP:0100641) | 1.76577698 |
| 86 | Dicarboxylic aciduria (HP:0003215) | 1.75983446 |
| 87 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.75983446 |
| 88 | Pendular nystagmus (HP:0012043) | 1.75303324 |
| 89 | Neutropenia (HP:0001875) | 1.74917590 |
| 90 | Abnormality of the pons (HP:0007361) | 1.73604149 |
| 91 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.73430244 |
| 92 | Attenuation of retinal blood vessels (HP:0007843) | 1.72571229 |
| 93 | Hypoplasia of the uterus (HP:0000013) | 1.69968124 |
| 94 | Prostate neoplasm (HP:0100787) | 1.69381718 |
| 95 | Megaloblastic anemia (HP:0001889) | 1.68771300 |
| 96 | Hyperphosphaturia (HP:0003109) | 1.67828094 |
| 97 | Panhypogammaglobulinemia (HP:0003139) | 1.67766075 |
| 98 | Reduced antithrombin III activity (HP:0001976) | 1.67649000 |
| 99 | Breast carcinoma (HP:0003002) | 1.67579748 |
| 100 | Abnormality of the prostate (HP:0008775) | 1.67155332 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.38533326 |
| 2 | EIF2AK3 | 3.98382721 |
| 3 | EIF2AK1 | 3.68174757 |
| 4 | FRK | 3.53230719 |
| 5 | TAF1 | 2.97742740 |
| 6 | MST4 | 2.76249892 |
| 7 | NUAK1 | 2.70010251 |
| 8 | TLK1 | 2.56120466 |
| 9 | ZAK | 2.51476378 |
| 10 | TIE1 | 2.42592953 |
| 11 | PBK | 2.41743311 |
| 12 | BUB1 | 2.36311943 |
| 13 | PDK2 | 2.14947845 |
| 14 | NEK1 | 2.14822896 |
| 15 | TXK | 1.97427094 |
| 16 | GRK1 | 1.97325277 |
| 17 | PLK3 | 1.90942707 |
| 18 | TSSK6 | 1.89024209 |
| 19 | FES | 1.80822816 |
| 20 | VRK1 | 1.79713968 |
| 21 | ADRBK2 | 1.63853956 |
| 22 | SRPK1 | 1.63146226 |
| 23 | FER | 1.49214337 |
| 24 | PASK | 1.40636521 |
| 25 | PLK2 | 1.40415662 |
| 26 | PLK4 | 1.37590379 |
| 27 | CCNB1 | 1.36992118 |
| 28 | BMPR1B | 1.36196649 |
| 29 | ACVR1B | 1.33891742 |
| 30 | EIF2AK2 | 1.29463442 |
| 31 | MAP4K1 | 1.25817890 |
| 32 | MAP3K12 | 1.23090445 |
| 33 | DAPK1 | 1.22774675 |
| 34 | STK39 | 1.18027195 |
| 35 | GRK5 | 1.16061059 |
| 36 | TRIM28 | 1.14046483 |
| 37 | WNK3 | 1.10138207 |
| 38 | TEC | 1.08861452 |
| 39 | SMG1 | 1.08012597 |
| 40 | CSNK1G3 | 1.06054307 |
| 41 | OXSR1 | 1.02942622 |
| 42 | CSNK1G1 | 1.00387880 |
| 43 | MKNK2 | 0.98100021 |
| 44 | BCR | 0.96257594 |
| 45 | NEK9 | 0.94369703 |
| 46 | WEE1 | 0.93707445 |
| 47 | CSNK1G2 | 0.88121414 |
| 48 | CSNK1A1L | 0.85440860 |
| 49 | BCKDK | 0.84929034 |
| 50 | DYRK2 | 0.81479350 |
| 51 | MAP2K6 | 0.79293027 |
| 52 | MAPKAPK3 | 0.77586796 |
| 53 | TAOK3 | 0.77522778 |
| 54 | WNK4 | 0.75030668 |
| 55 | PLK1 | 0.74428330 |
| 56 | MAP4K2 | 0.72968321 |
| 57 | PINK1 | 0.72714117 |
| 58 | TGFBR1 | 0.65162170 |
| 59 | ALK | 0.63947423 |
| 60 | NEK2 | 0.63689057 |
| 61 | STK4 | 0.60868447 |
| 62 | NME1 | 0.57932099 |
| 63 | TNIK | 0.57082875 |
| 64 | INSRR | 0.56616862 |
| 65 | STK16 | 0.55694389 |
| 66 | ATR | 0.54407421 |
| 67 | MYLK | 0.53609457 |
| 68 | MKNK1 | 0.53044863 |
| 69 | IKBKB | 0.52569730 |
| 70 | ITK | 0.51744824 |
| 71 | PHKG2 | 0.50690047 |
| 72 | PHKG1 | 0.50690047 |
| 73 | MAPKAPK5 | 0.48226986 |
| 74 | AURKB | 0.47477498 |
| 75 | FGFR2 | 0.46880679 |
| 76 | TGFBR2 | 0.44195088 |
| 77 | SCYL2 | 0.42929322 |
| 78 | DAPK3 | 0.42097599 |
| 79 | SYK | 0.39686986 |
| 80 | PTK2B | 0.36264252 |
| 81 | TTK | 0.35495309 |
| 82 | PRKCE | 0.35140441 |
| 83 | CDK8 | 0.35001073 |
| 84 | STK3 | 0.34976010 |
| 85 | ADRBK1 | 0.34410305 |
| 86 | LYN | 0.34009155 |
| 87 | CDK9 | 0.33336091 |
| 88 | PRKCQ | 0.32964586 |
| 89 | STK38L | 0.32860245 |
| 90 | PRKCG | 0.32797948 |
| 91 | CSNK2A1 | 0.32533872 |
| 92 | PRKCD | 0.31208948 |
| 93 | CSNK1A1 | 0.30839095 |
| 94 | PRKCI | 0.30779526 |
| 95 | KIT | 0.28933992 |
| 96 | PRKCA | 0.25838561 |
| 97 | CAMKK2 | 0.24057488 |
| 98 | IRAK1 | 0.23534407 |
| 99 | IGF1R | 0.23371194 |
| 100 | MELK | 0.22191877 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.29360749 |
| 2 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.73506607 |
| 3 | Protein export_Homo sapiens_hsa03060 | 3.49918641 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 2.78167897 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.61440530 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.46766222 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.31944588 |
| 8 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.10481158 |
| 9 | Asthma_Homo sapiens_hsa05310 | 1.97699383 |
| 10 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.97276798 |
| 11 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.90112125 |
| 12 | Mismatch repair_Homo sapiens_hsa03430 | 1.87364400 |
| 13 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.85789836 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.82523137 |
| 15 | Homologous recombination_Homo sapiens_hsa03440 | 1.71041666 |
| 16 | Allograft rejection_Homo sapiens_hsa05330 | 1.62690897 |
| 17 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.62416815 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.55857131 |
| 19 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.53163317 |
| 20 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.50788051 |
| 21 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.49844519 |
| 22 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.47316815 |
| 23 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.47282877 |
| 24 | Huntingtons disease_Homo sapiens_hsa05016 | 1.45283619 |
| 25 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.43702904 |
| 26 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.42703394 |
| 27 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.35449179 |
| 28 | Basal transcription factors_Homo sapiens_hsa03022 | 1.34962351 |
| 29 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.34700612 |
| 30 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.28152449 |
| 31 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.22355723 |
| 32 | Alzheimers disease_Homo sapiens_hsa05010 | 1.21205559 |
| 33 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.20117443 |
| 34 | DNA replication_Homo sapiens_hsa03030 | 1.18447928 |
| 35 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.18174653 |
| 36 | RNA transport_Homo sapiens_hsa03013 | 1.17079342 |
| 37 | Ribosome_Homo sapiens_hsa03010 | 1.16800406 |
| 38 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.15718290 |
| 39 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.14277880 |
| 40 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.05339367 |
| 41 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.00612651 |
| 42 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.00263055 |
| 43 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.99994758 |
| 44 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.98554506 |
| 45 | Purine metabolism_Homo sapiens_hsa00230 | 0.98053990 |
| 46 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.97151451 |
| 47 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.96430676 |
| 48 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.96427642 |
| 49 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.95577253 |
| 50 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.95506693 |
| 51 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.95241727 |
| 52 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.94851608 |
| 53 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.94851497 |
| 54 | Phototransduction_Homo sapiens_hsa04744 | 0.93470613 |
| 55 | Peroxisome_Homo sapiens_hsa04146 | 0.92675682 |
| 56 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.92491108 |
| 57 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.89707677 |
| 58 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.88945155 |
| 59 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.88900275 |
| 60 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.86578655 |
| 61 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.83343397 |
| 62 | Base excision repair_Homo sapiens_hsa03410 | 0.82524638 |
| 63 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.81529589 |
| 64 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.81159936 |
| 65 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.80415316 |
| 66 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.80032718 |
| 67 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.77255760 |
| 68 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.77112935 |
| 69 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.76657522 |
| 70 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.76522483 |
| 71 | Carbon metabolism_Homo sapiens_hsa01200 | 0.76218266 |
| 72 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.75665498 |
| 73 | Spliceosome_Homo sapiens_hsa03040 | 0.74150164 |
| 74 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.73851084 |
| 75 | Metabolic pathways_Homo sapiens_hsa01100 | 0.72269046 |
| 76 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.68721748 |
| 77 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.68605111 |
| 78 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.67594976 |
| 79 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.66902442 |
| 80 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.64221616 |
| 81 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.62563693 |
| 82 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.61595189 |
| 83 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.60582018 |
| 84 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.60280579 |
| 85 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.59398661 |
| 86 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.59128287 |
| 87 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.58798790 |
| 88 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.58428468 |
| 89 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.54260841 |
| 90 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.50175753 |
| 91 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.48193200 |
| 92 | Retinol metabolism_Homo sapiens_hsa00830 | 0.44526508 |
| 93 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.42563887 |
| 94 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.41190657 |
| 95 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.39750758 |
| 96 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.38923422 |
| 97 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.38863459 |
| 98 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.35779389 |
| 99 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.34880040 |
| 100 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.33606229 |

