SLC25A5P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)6.35466934
2DNA deamination (GO:0045006)6.25903936
3proteasome assembly (GO:0043248)5.40912176
4respiratory chain complex IV assembly (GO:0008535)4.86717714
5cytochrome complex assembly (GO:0017004)4.46856829
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.19607031
7ATP synthesis coupled proton transport (GO:0015986)4.19607031
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.15169304
9transcription elongation from RNA polymerase III promoter (GO:0006385)3.93038063
10termination of RNA polymerase III transcription (GO:0006386)3.93038063
11rRNA modification (GO:0000154)3.88860622
12signal peptide processing (GO:0006465)3.86771573
13protein complex biogenesis (GO:0070271)3.79894877
14kynurenine metabolic process (GO:0070189)3.79714392
15cullin deneddylation (GO:0010388)3.77313156
16establishment of protein localization to mitochondrial membrane (GO:0090151)3.76174792
17exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.69622654
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.67621061
19somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.65658360
20somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.65658360
21isotype switching (GO:0045190)3.65658360
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.63100673
23NADH dehydrogenase complex assembly (GO:0010257)3.63100673
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63100673
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.62378250
26protein deneddylation (GO:0000338)3.61433186
27DNA damage response, detection of DNA damage (GO:0042769)3.60057363
28mitochondrial respiratory chain complex assembly (GO:0033108)3.58240673
29regulation of cellular amino acid metabolic process (GO:0006521)3.57202087
30DNA double-strand break processing (GO:0000729)3.56597128
31DNA catabolic process, exonucleolytic (GO:0000738)3.49457526
32tryptophan catabolic process (GO:0006569)3.45418450
33indole-containing compound catabolic process (GO:0042436)3.45418450
34indolalkylamine catabolic process (GO:0046218)3.45418450
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45270570
36rRNA methylation (GO:0031167)3.40244266
37vitamin biosynthetic process (GO:0009110)3.38391347
38DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.36774538
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33671067
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.32699454
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.32699454
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.32699454
43response to pheromone (GO:0019236)3.30375629
44pseudouridine synthesis (GO:0001522)3.28744597
45piRNA metabolic process (GO:0034587)3.27951875
46cytidine metabolic process (GO:0046087)3.26974361
47cytidine catabolic process (GO:0006216)3.26974361
48cytidine deamination (GO:0009972)3.26974361
49signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26633914
50intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26633914
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23697546
52aldehyde catabolic process (GO:0046185)3.21068531
53tryptophan metabolic process (GO:0006568)3.18610772
54signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12732933
55signal transduction involved in DNA damage checkpoint (GO:0072422)3.12732933
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12444542
57ribosome assembly (GO:0042255)3.09083765
58non-recombinational repair (GO:0000726)3.06738336
59double-strand break repair via nonhomologous end joining (GO:0006303)3.06738336
60signal transduction involved in cell cycle checkpoint (GO:0072395)3.06734759
61positive regulation of prostaglandin secretion (GO:0032308)3.05811111
62protein neddylation (GO:0045116)3.04092909
63negative regulation of ligase activity (GO:0051352)3.02937706
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02937706
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.99868392
66indolalkylamine metabolic process (GO:0006586)2.99635094
67negative regulation of T cell differentiation in thymus (GO:0033085)2.96873482
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95981669
69synapsis (GO:0007129)2.95061437
70chromatin remodeling at centromere (GO:0031055)2.89509353
71chaperone-mediated protein transport (GO:0072321)2.88633506
72respiratory electron transport chain (GO:0022904)2.88123028
73electron transport chain (GO:0022900)2.87087884
74somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82887297
75somatic hypermutation of immunoglobulin genes (GO:0016446)2.82887297
76CENP-A containing nucleosome assembly (GO:0034080)2.80783311
77histone exchange (GO:0043486)2.80655867
78mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78202407
79GTP biosynthetic process (GO:0006183)2.77417025
80positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76192060
81organelle disassembly (GO:1903008)2.71735358
82positive regulation of ligase activity (GO:0051351)2.70504574
83amino acid salvage (GO:0043102)2.69310438
84L-methionine salvage (GO:0071267)2.69310438
85L-methionine biosynthetic process (GO:0071265)2.69310438
86somatic diversification of immunoglobulins (GO:0016445)2.68726833
87AMP metabolic process (GO:0046033)2.67629531
88DNA ligation (GO:0006266)2.66121985
89regulation of cellular amine metabolic process (GO:0033238)2.65500339
90somatic recombination of immunoglobulin gene segments (GO:0016447)2.65455305
91phosphatidylinositol acyl-chain remodeling (GO:0036149)2.63535512
92purine nucleoside triphosphate biosynthetic process (GO:0009145)2.60788968
93pyrimidine ribonucleoside catabolic process (GO:0046133)2.60704829
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60009840
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60009840
96regulation of oxidative phosphorylation (GO:0002082)2.57324577
97DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.57102231
98iron-sulfur cluster assembly (GO:0016226)2.56606299
99metallo-sulfur cluster assembly (GO:0031163)2.56606299
100maturation of 5.8S rRNA (GO:0000460)2.55512907

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.01357286
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.47386510
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.17590169
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.62092780
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.40819425
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08262710
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.05689743
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92031983
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.76358002
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48251456
11VDR_23849224_ChIP-Seq_CD4+_Human2.46245477
12ZNF274_21170338_ChIP-Seq_K562_Hela2.40996910
13FOXP3_21729870_ChIP-Seq_TREG_Human2.33674940
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31946310
15VDR_22108803_ChIP-Seq_LS180_Human2.31911254
16ELK1_19687146_ChIP-ChIP_HELA_Human2.31267658
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29570060
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22091136
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21192739
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.04479669
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.00525165
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97370084
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.92493932
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77510198
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75513219
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73749856
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70513036
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.61151421
29MYC_18940864_ChIP-ChIP_HL60_Human1.60391307
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58620286
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52626090
32EWS_26573619_Chip-Seq_HEK293_Human1.52378103
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52325022
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.51677385
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49697672
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47944611
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47692471
38DCP1A_22483619_ChIP-Seq_HELA_Human1.46574209
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41776816
40IGF1R_20145208_ChIP-Seq_DFB_Human1.39397173
41IRF1_19129219_ChIP-ChIP_H3396_Human1.39389966
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38260153
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37848747
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36450959
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33568917
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.32864842
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30380675
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28902458
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26752909
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26368746
51GABP_19822575_ChIP-Seq_HepG2_Human1.23496459
52ER_23166858_ChIP-Seq_MCF-7_Human1.21409656
53AR_20517297_ChIP-Seq_VCAP_Human1.20734682
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.19382964
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17770687
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.17770687
57GATA3_26560356_Chip-Seq_TH2_Human1.16006144
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.12522991
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11167367
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11158968
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10841698
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10249453
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10069528
64SOX2_19829295_ChIP-Seq_ESCs_Human1.10055810
65NANOG_19829295_ChIP-Seq_ESCs_Human1.10055810
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09139681
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08035614
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07580875
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07320219
70TTF2_22483619_ChIP-Seq_HELA_Human1.06865277
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06619456
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05900596
73IRF8_22096565_ChIP-ChIP_GC-B_Human1.05838750
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03834960
75TP53_22573176_ChIP-Seq_HFKS_Human1.03171757
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02677397
77PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02615206
78PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01954214
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00887584
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99374736
81IRF8_21731497_ChIP-ChIP_J774_Mouse0.99175486
82NCOR_22424771_ChIP-Seq_293T_Human0.99042479
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97668211
84E2F7_22180533_ChIP-Seq_HELA_Human0.96046218
85FOXH1_21741376_ChIP-Seq_EPCs_Human0.95967946
86HOXB7_26014856_ChIP-Seq_BT474_Human0.93998253
87P300_19829295_ChIP-Seq_ESCs_Human0.91647538
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91439754
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.91360942
90GATA6_21074721_ChIP-Seq_CACO-2_Human0.89554715
91FUS_26573619_Chip-Seq_HEK293_Human0.88837681
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88336946
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88148699
94MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87006076
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85463321
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85455114
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85435492
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84930987
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84215402
100SALL4_22934838_ChIP-ChIP_CD34+_Human0.84033738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok3.51308163
2MP0003646_muscle_fatigue3.34544695
3MP0000372_irregular_coat_pigmentation3.31539683
4MP0002102_abnormal_ear_morphology3.19652695
5MP0003806_abnormal_nucleotide_metabolis3.10607774
6MP0003195_calcinosis2.91371549
7MP0002138_abnormal_hepatobiliary_system2.63840441
8MP0008058_abnormal_DNA_repair2.57587571
9MP0006036_abnormal_mitochondrial_physio2.52386474
10MP0003693_abnormal_embryo_hatching2.33762624
11MP0008872_abnormal_physiological_respon2.32985507
12MP0010094_abnormal_chromosome_stability2.24926782
13MP0005671_abnormal_response_to2.11710145
14MP0002006_tumorigenesis2.10288295
15MP0008877_abnormal_DNA_methylation2.01455205
16MP0002166_altered_tumor_susceptibility2.00025698
17MP0000685_abnormal_immune_system1.96817023
18MP0004147_increased_porphyrin_level1.95190789
19MP0004957_abnormal_blastocyst_morpholog1.91798965
20MP0009333_abnormal_splenocyte_physiolog1.82365920
21MP0004885_abnormal_endolymph1.81280620
22MP0005075_abnormal_melanosome_morpholog1.80169449
23MP0001348_abnormal_lacrimal_gland1.77133241
24MP0005360_urolithiasis1.69747725
25MP0005084_abnormal_gallbladder_morpholo1.69064317
26MP0001835_abnormal_antigen_presentation1.60865906
27MP0003567_abnormal_fetal_cardiomyocyte1.59493710
28MP0001661_extended_life_span1.58727786
29MP0006035_abnormal_mitochondrial_morpho1.55941010
30MP0002736_abnormal_nociception_after1.54908557
31MP0005379_endocrine/exocrine_gland_phen1.54523855
32MP0005646_abnormal_pituitary_gland1.53853442
33MP0001968_abnormal_touch/_nociception1.52636291
34MP0009697_abnormal_copulation1.51876036
35MP0005085_abnormal_gallbladder_physiolo1.48011877
36MP0005167_abnormal_blood-brain_barrier1.40368391
37MP0006072_abnormal_retinal_apoptosis1.38083764
38MP0003186_abnormal_redox_activity1.35990869
39MP0003786_premature_aging1.35558483
40MP0002876_abnormal_thyroid_physiology1.35487420
41MP0009046_muscle_twitch1.34272838
42MP0002148_abnormal_hypersensitivity_rea1.31682632
43MP0001485_abnormal_pinna_reflex1.31185371
44MP0010386_abnormal_urinary_bladder1.29787916
45MP0001986_abnormal_taste_sensitivity1.29269424
46MP0002163_abnormal_gland_morphology1.28764080
47MP0003718_maternal_effect1.28454270
48MP0001764_abnormal_homeostasis1.27382266
49MP0005332_abnormal_amino_acid1.26650691
50MP0004742_abnormal_vestibular_system1.24452542
51MP0005408_hypopigmentation1.24230739
52MP0001800_abnormal_humoral_immune1.23422186
53MP0002095_abnormal_skin_pigmentation1.20469328
54MP0004145_abnormal_muscle_electrophysio1.19524789
55MP0005387_immune_system_phenotype1.16626724
56MP0001790_abnormal_immune_system1.16626724
57MP0005636_abnormal_mineral_homeostasis1.12727777
58MP0003111_abnormal_nucleus_morphology1.12425509
59MP0000613_abnormal_salivary_gland1.11960399
60MP0003866_abnormal_defecation1.10641374
61MP0003950_abnormal_plasma_membrane1.08276094
62MP0005083_abnormal_biliary_tract1.08184569
63MP0006054_spinal_hemorrhage1.05891044
64MP0008007_abnormal_cellular_replicative1.05877386
65MP0005174_abnormal_tail_pigmentation1.00763832
66MP0005171_absent_coat_pigmentation0.98205595
67MP0005389_reproductive_system_phenotype0.97829934
68MP0002272_abnormal_nervous_system0.97645583
69MP0000015_abnormal_ear_pigmentation0.92243569
70MP0005367_renal/urinary_system_phenotyp0.90694620
71MP0000516_abnormal_urinary_system0.90694620
72MP0006082_CNS_inflammation0.90126156
73MP0005551_abnormal_eye_electrophysiolog0.87589540
74MP0001929_abnormal_gametogenesis0.85721236
75MP0005253_abnormal_eye_physiology0.85259386
76MP0003252_abnormal_bile_duct0.83604265
77MP0001873_stomach_inflammation0.81882244
78MP0005310_abnormal_salivary_gland0.81035892
79MP0002277_abnormal_respiratory_mucosa0.80813457
80MP0002837_dystrophic_cardiac_calcinosis0.80763612
81MP0002693_abnormal_pancreas_physiology0.80253498
82MP0005645_abnormal_hypothalamus_physiol0.79644649
83MP0000427_abnormal_hair_cycle0.79182665
84MP0001756_abnormal_urination0.78599613
85MP0004215_abnormal_myocardial_fiber0.76969007
86MP0001919_abnormal_reproductive_system0.76604978
87MP0002723_abnormal_immune_serum0.76095361
88MP0009785_altered_susceptibility_to0.75844399
89MP0000689_abnormal_spleen_morphology0.74995291
90MP0002452_abnormal_antigen_presenting0.74160125
91MP0004381_abnormal_hair_follicle0.72791629
92MP0005000_abnormal_immune_tolerance0.72583105
93MP0009643_abnormal_urine_homeostasis0.72428935
94MP0003878_abnormal_ear_physiology0.72284124
95MP0005377_hearing/vestibular/ear_phenot0.72284124
96MP0005365_abnormal_bile_salt0.70614265
97MP0008873_increased_physiological_sensi0.70346113
98MP0002420_abnormal_adaptive_immunity0.68903308
99MP0005319_abnormal_enzyme/_coenzyme0.68525054
100MP0001819_abnormal_immune_cell0.68269958

Predicted human phenotypes

RankGene SetZ-score
1Increased CSF lactate (HP:0002490)4.14375125
2Mitochondrial inheritance (HP:0001427)3.97813013
3Hepatocellular necrosis (HP:0001404)3.93153820
4Hepatic necrosis (HP:0002605)3.91202713
5Acute necrotizing encephalopathy (HP:0006965)3.82823882
6Increased hepatocellular lipid droplets (HP:0006565)3.74317876
7Progressive macrocephaly (HP:0004481)3.57630253
8Acute encephalopathy (HP:0006846)3.41475996
9Methylmalonic acidemia (HP:0002912)3.31828588
10Lipid accumulation in hepatocytes (HP:0006561)3.28158736
11Increased serum lactate (HP:0002151)3.23397671
12Abnormal mitochondria in muscle tissue (HP:0008316)3.22270399
13Methylmalonic aciduria (HP:0012120)3.01013870
14Colon cancer (HP:0003003)2.98595704
15Cerebral edema (HP:0002181)2.87343293
16Renal Fanconi syndrome (HP:0001994)2.85600993
17Abnormality of the labia minora (HP:0012880)2.79636050
183-Methylglutaconic aciduria (HP:0003535)2.75866667
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.67408255
20Elevated erythrocyte sedimentation rate (HP:0003565)2.66377328
21Lactic acidosis (HP:0003128)2.63242346
22Large for gestational age (HP:0001520)2.61353763
23Abnormality of urine glucose concentration (HP:0011016)2.60927211
24Glycosuria (HP:0003076)2.60927211
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.60183226
26Hypothermia (HP:0002045)2.59228011
27Hyperglycinemia (HP:0002154)2.54896841
28Lethargy (HP:0001254)2.54431076
29Conjunctival hamartoma (HP:0100780)2.49253719
30Exertional dyspnea (HP:0002875)2.48482835
31Congenital stationary night blindness (HP:0007642)2.45646499
32Abnormality of glycine metabolism (HP:0010895)2.35314724
33Abnormality of serine family amino acid metabolism (HP:0010894)2.35314724
34Abnormality of methionine metabolism (HP:0010901)2.32673440
35Respiratory difficulties (HP:0002880)2.32604778
36IgG deficiency (HP:0004315)2.32375717
37Type I transferrin isoform profile (HP:0003642)2.32249714
38Respiratory failure (HP:0002878)2.32084184
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.29068310
40Optic disc pallor (HP:0000543)2.26961116
41Abnormality of B cell number (HP:0010975)2.26343352
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26095494
43Abnormality of the vitamin B12 metabolism (HP:0004341)2.23704845
44Duplicated collecting system (HP:0000081)2.23622625
45Abnormality of the renal collecting system (HP:0004742)2.22083583
46Neoplasm of the adrenal gland (HP:0100631)2.22077719
47Abolished electroretinogram (ERG) (HP:0000550)2.21264612
48Abnormality of serum amino acid levels (HP:0003112)2.21194816
49Congenital, generalized hypertrichosis (HP:0004540)2.18162245
50Abnormality of vitamin B metabolism (HP:0004340)2.15391108
51Increased intramyocellular lipid droplets (HP:0012240)2.11238046
52Pancytopenia (HP:0001876)2.09844787
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09188096
54Ketoacidosis (HP:0001993)2.07772439
55Adrenal hypoplasia (HP:0000835)2.07000306
56Palpitations (HP:0001962)2.06919618
57Hypoproteinemia (HP:0003075)2.06827079
58Ketosis (HP:0001946)2.06566318
59B lymphocytopenia (HP:0010976)2.05288141
60CNS demyelination (HP:0007305)2.04806855
61Molar tooth sign on MRI (HP:0002419)2.03405491
62Abnormality of midbrain morphology (HP:0002418)2.03405491
63Hyperglycinuria (HP:0003108)2.02825524
64Pancreatic cysts (HP:0001737)2.02488631
65Supernumerary spleens (HP:0009799)2.02375304
66Exercise intolerance (HP:0003546)2.01106033
67Aplasia/hypoplasia of the uterus (HP:0008684)2.01031239
68Cerebral hypomyelination (HP:0006808)2.00958791
69Renal cortical cysts (HP:0000803)2.00444176
70Abnormality of the renal cortex (HP:0011035)1.99609852
71Abnormality of T cell physiology (HP:0011840)1.96636454
72Hypoglycemic coma (HP:0001325)1.96156977
73Generalized aminoaciduria (HP:0002909)1.95136316
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89703334
75Abnormality of alanine metabolism (HP:0010916)1.89703334
76Hyperalaninemia (HP:0003348)1.89703334
77IgM deficiency (HP:0002850)1.89610100
78Ependymoma (HP:0002888)1.84901139
79Stillbirth (HP:0003826)1.83608384
80Decreased central vision (HP:0007663)1.80190839
81Autoimmune hemolytic anemia (HP:0001890)1.79589214
82Hypomagnesemia (HP:0002917)1.79181940
83Leukodystrophy (HP:0002415)1.78153468
84Increased serum pyruvate (HP:0003542)1.77824035
85Neoplasm of the adrenal cortex (HP:0100641)1.76577698
86Dicarboxylic aciduria (HP:0003215)1.75983446
87Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75983446
88Pendular nystagmus (HP:0012043)1.75303324
89Neutropenia (HP:0001875)1.74917590
90Abnormality of the pons (HP:0007361)1.73604149
91Aplasia/Hypoplasia involving the musculature (HP:0001460)1.73430244
92Attenuation of retinal blood vessels (HP:0007843)1.72571229
93Hypoplasia of the uterus (HP:0000013)1.69968124
94Prostate neoplasm (HP:0100787)1.69381718
95Megaloblastic anemia (HP:0001889)1.68771300
96Hyperphosphaturia (HP:0003109)1.67828094
97Panhypogammaglobulinemia (HP:0003139)1.67766075
98Reduced antithrombin III activity (HP:0001976)1.67649000
99Breast carcinoma (HP:0003002)1.67579748
100Abnormality of the prostate (HP:0008775)1.67155332

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.38533326
2EIF2AK33.98382721
3EIF2AK13.68174757
4FRK3.53230719
5TAF12.97742740
6MST42.76249892
7NUAK12.70010251
8TLK12.56120466
9ZAK2.51476378
10TIE12.42592953
11PBK2.41743311
12BUB12.36311943
13PDK22.14947845
14NEK12.14822896
15TXK1.97427094
16GRK11.97325277
17PLK31.90942707
18TSSK61.89024209
19FES1.80822816
20VRK11.79713968
21ADRBK21.63853956
22SRPK11.63146226
23FER1.49214337
24PASK1.40636521
25PLK21.40415662
26PLK41.37590379
27CCNB11.36992118
28BMPR1B1.36196649
29ACVR1B1.33891742
30EIF2AK21.29463442
31MAP4K11.25817890
32MAP3K121.23090445
33DAPK11.22774675
34STK391.18027195
35GRK51.16061059
36TRIM281.14046483
37WNK31.10138207
38TEC1.08861452
39SMG11.08012597
40CSNK1G31.06054307
41OXSR11.02942622
42CSNK1G11.00387880
43MKNK20.98100021
44BCR0.96257594
45NEK90.94369703
46WEE10.93707445
47CSNK1G20.88121414
48CSNK1A1L0.85440860
49BCKDK0.84929034
50DYRK20.81479350
51MAP2K60.79293027
52MAPKAPK30.77586796
53TAOK30.77522778
54WNK40.75030668
55PLK10.74428330
56MAP4K20.72968321
57PINK10.72714117
58TGFBR10.65162170
59ALK0.63947423
60NEK20.63689057
61STK40.60868447
62NME10.57932099
63TNIK0.57082875
64INSRR0.56616862
65STK160.55694389
66ATR0.54407421
67MYLK0.53609457
68MKNK10.53044863
69IKBKB0.52569730
70ITK0.51744824
71PHKG20.50690047
72PHKG10.50690047
73MAPKAPK50.48226986
74AURKB0.47477498
75FGFR20.46880679
76TGFBR20.44195088
77SCYL20.42929322
78DAPK30.42097599
79SYK0.39686986
80PTK2B0.36264252
81TTK0.35495309
82PRKCE0.35140441
83CDK80.35001073
84STK30.34976010
85ADRBK10.34410305
86LYN0.34009155
87CDK90.33336091
88PRKCQ0.32964586
89STK38L0.32860245
90PRKCG0.32797948
91CSNK2A10.32533872
92PRKCD0.31208948
93CSNK1A10.30839095
94PRKCI0.30779526
95KIT0.28933992
96PRKCA0.25838561
97CAMKK20.24057488
98IRAK10.23534407
99IGF1R0.23371194
100MELK0.22191877

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.29360749
2Caffeine metabolism_Homo sapiens_hsa002323.73506607
3Protein export_Homo sapiens_hsa030603.49918641
4RNA polymerase_Homo sapiens_hsa030202.78167897
5Oxidative phosphorylation_Homo sapiens_hsa001902.61440530
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46766222
7Parkinsons disease_Homo sapiens_hsa050122.31944588
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.10481158
9Asthma_Homo sapiens_hsa053101.97699383
10Non-homologous end-joining_Homo sapiens_hsa034501.97276798
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90112125
12Mismatch repair_Homo sapiens_hsa034301.87364400
13Propanoate metabolism_Homo sapiens_hsa006401.85789836
14One carbon pool by folate_Homo sapiens_hsa006701.82523137
15Homologous recombination_Homo sapiens_hsa034401.71041666
16Allograft rejection_Homo sapiens_hsa053301.62690897
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62416815
18RNA degradation_Homo sapiens_hsa030181.55857131
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53163317
20Tryptophan metabolism_Homo sapiens_hsa003801.50788051
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49844519
22Nitrogen metabolism_Homo sapiens_hsa009101.47316815
23Autoimmune thyroid disease_Homo sapiens_hsa053201.47282877
24Huntingtons disease_Homo sapiens_hsa050161.45283619
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.43702904
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42703394
27Pyruvate metabolism_Homo sapiens_hsa006201.35449179
28Basal transcription factors_Homo sapiens_hsa030221.34962351
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34700612
30Linoleic acid metabolism_Homo sapiens_hsa005911.28152449
31Sulfur metabolism_Homo sapiens_hsa009201.22355723
32Alzheimers disease_Homo sapiens_hsa050101.21205559
33Pyrimidine metabolism_Homo sapiens_hsa002401.20117443
34DNA replication_Homo sapiens_hsa030301.18447928
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18174653
36RNA transport_Homo sapiens_hsa030131.17079342
37Ribosome_Homo sapiens_hsa030101.16800406
38Type I diabetes mellitus_Homo sapiens_hsa049401.15718290
39Vitamin B6 metabolism_Homo sapiens_hsa007501.14277880
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05339367
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00612651
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00263055
43Fanconi anemia pathway_Homo sapiens_hsa034600.99994758
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98554506
45Purine metabolism_Homo sapiens_hsa002300.98053990
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.97151451
47Primary immunodeficiency_Homo sapiens_hsa053400.96430676
48Graft-versus-host disease_Homo sapiens_hsa053320.96427642
49Butanoate metabolism_Homo sapiens_hsa006500.95577253
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95506693
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95241727
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94851608
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94851497
54Phototransduction_Homo sapiens_hsa047440.93470613
55Peroxisome_Homo sapiens_hsa041460.92675682
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92491108
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.89707677
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88945155
59Nucleotide excision repair_Homo sapiens_hsa034200.88900275
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86578655
61Collecting duct acid secretion_Homo sapiens_hsa049660.83343397
62Base excision repair_Homo sapiens_hsa034100.82524638
63Fatty acid elongation_Homo sapiens_hsa000620.81529589
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81159936
65Selenocompound metabolism_Homo sapiens_hsa004500.80415316
66Fatty acid degradation_Homo sapiens_hsa000710.80032718
67beta-Alanine metabolism_Homo sapiens_hsa004100.77255760
68Rheumatoid arthritis_Homo sapiens_hsa053230.77112935
69Glutathione metabolism_Homo sapiens_hsa004800.76657522
70Chemical carcinogenesis_Homo sapiens_hsa052040.76522483
71Carbon metabolism_Homo sapiens_hsa012000.76218266
72Ether lipid metabolism_Homo sapiens_hsa005650.75665498
73Spliceosome_Homo sapiens_hsa030400.74150164
74Steroid biosynthesis_Homo sapiens_hsa001000.73851084
75Metabolic pathways_Homo sapiens_hsa011000.72269046
76Arachidonic acid metabolism_Homo sapiens_hsa005900.68721748
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.68605111
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.67594976
79Antigen processing and presentation_Homo sapiens_hsa046120.66902442
80Biosynthesis of amino acids_Homo sapiens_hsa012300.64221616
81N-Glycan biosynthesis_Homo sapiens_hsa005100.62563693
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.61595189
83Pentose phosphate pathway_Homo sapiens_hsa000300.60582018
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60280579
85Glycerolipid metabolism_Homo sapiens_hsa005610.59398661
86Fat digestion and absorption_Homo sapiens_hsa049750.59128287
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58798790
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58428468
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54260841
90Arginine biosynthesis_Homo sapiens_hsa002200.50175753
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48193200
92Retinol metabolism_Homo sapiens_hsa008300.44526508
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42563887
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41190657
95Systemic lupus erythematosus_Homo sapiens_hsa053220.39750758
96p53 signaling pathway_Homo sapiens_hsa041150.38923422
97Starch and sucrose metabolism_Homo sapiens_hsa005000.38863459
98Cardiac muscle contraction_Homo sapiens_hsa042600.35779389
99Fatty acid metabolism_Homo sapiens_hsa012120.34880040
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33606229

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