ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	7.01972269
2	proteasome assembly (GO:0043248)	5.57216929
3	cullin deneddylation (GO:0010388)	4.51701907
4	plasma membrane fusion (GO:0045026)	4.19664608
5	protein deneddylation (GO:0000338)	4.10754524
6	organelle disassembly (GO:1903008)	3.97987111
7	melanin biosynthetic process (GO:0042438)	3.95291803
8	rRNA methylation (GO:0031167)	3.84390005
9	signal peptide processing (GO:0006465)	3.76994359
10	kynurenine metabolic process (GO:0070189)	3.76768331
11	tryptophan metabolic process (GO:0006568)	3.71590102
12	DNA deamination (GO:0045006)	3.71039315
13	rRNA modification (GO:0000154)	3.67387599
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.64702722
15	secondary metabolite biosynthetic process (GO:0044550)	3.64155951
16	aldehyde catabolic process (GO:0046185)	3.63405640
17	positive regulation of receptor recycling (GO:0001921)	3.61385850
18	regulation of centriole replication (GO:0046599)	3.60952062
19	melanin metabolic process (GO:0006582)	3.60357096
20	indolalkylamine catabolic process (GO:0046218)	3.51994271
21	tryptophan catabolic process (GO:0006569)	3.51994271
22	indole-containing compound catabolic process (GO:0042436)	3.51994271
23	mitotic G2 DNA damage checkpoint (GO:0007095)	3.51803544
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.48987890
25	ribonucleoprotein complex disassembly (GO:0032988)	3.42163699
26	mitochondrial DNA replication (GO:0006264)	3.37141421
27	indolalkylamine metabolic process (GO:0006586)	3.36087776
28	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.35526873
29	mitotic G2/M transition checkpoint (GO:0044818)	3.33923564
30	ribosome assembly (GO:0042255)	3.30675478
31	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.30667571
32	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.27223748
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.26505643
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.26505643
35	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.25757689
36	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.25751803
37	lysine catabolic process (GO:0006554)	3.25565588
38	lysine metabolic process (GO:0006553)	3.25565588
39	regulation of cellular amino acid metabolic process (GO:0006521)	3.23798736
40	histone exchange (GO:0043486)	3.21457939
41	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.18819737
42	ATP synthesis coupled proton transport (GO:0015986)	3.18819737
43	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.18265798
44	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.18265798
45	artery smooth muscle contraction (GO:0014824)	3.17670892
46	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.16820402
47	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.16820402
48	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.16820402
49	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.12685603
50	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.12595888
51	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.12550544
52	IMP biosynthetic process (GO:0006188)	3.11576504
53	nucleotide transmembrane transport (GO:1901679)	3.07987563
54	DNA replication checkpoint (GO:0000076)	3.06095192
55	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.04566090
56	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.04566090
57	negative regulation of ligase activity (GO:0051352)	3.01054565
58	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.01054565
59	CENP-A containing nucleosome assembly (GO:0034080)	2.99889140
60	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.97728262
61	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.97728262
62	regulation of DNA endoreduplication (GO:0032875)	2.95812577
63	pseudouridine synthesis (GO:0001522)	2.94743735
64	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.91428759
65	dopamine transport (GO:0015872)	2.90757278
66	tRNA aminoacylation (GO:0043039)	2.90009323
67	amino acid activation (GO:0043038)	2.90009323
68	double-strand break repair via homologous recombination (GO:0000724)	2.87433874
69	recombinational repair (GO:0000725)	2.86769717
70	replication fork processing (GO:0031297)	2.86503463
71	nucleoside transmembrane transport (GO:1901642)	2.86389445
72	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.86169741
73	histamine secretion (GO:0001821)	2.85318948
74	IMP metabolic process (GO:0046040)	2.83986401
75	chromatin remodeling at centromere (GO:0031055)	2.81837160
76	DNA strand elongation involved in DNA replication (GO:0006271)	2.81337639
77	tRNA aminoacylation for protein translation (GO:0006418)	2.80487157
78	respiratory chain complex IV assembly (GO:0008535)	2.79938353
79	protein K6-linked ubiquitination (GO:0085020)	2.78697412
80	tonic smooth muscle contraction (GO:0014820)	2.76106728
81	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.74659853
82	endosome to melanosome transport (GO:0035646)	2.73285235
83	endosome to pigment granule transport (GO:0043485)	2.73285235
84	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.71361565
85	tRNA metabolic process (GO:0006399)	2.70237891
86	mitochondrial RNA metabolic process (GO:0000959)	2.70154332
87	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.66841371
88	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.66006798
89	platelet dense granule organization (GO:0060155)	2.63762407
90	ketone body metabolic process (GO:1902224)	2.63137471
91	L-methionine salvage (GO:0071267)	2.63017119
92	L-methionine biosynthetic process (GO:0071265)	2.63017119
93	amino acid salvage (GO:0043102)	2.63017119
94	piRNA metabolic process (GO:0034587)	2.62541061
95	rRNA catabolic process (GO:0016075)	2.62339119
96	regulation of centrosome cycle (GO:0046605)	2.61925356
97	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.61524344
98	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.60731286
99	spindle assembly involved in mitosis (GO:0090307)	2.60584601
100	melanosome organization (GO:0032438)	2.60449736

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.97094571
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.14174175
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.70179379
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.67021422
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.48551538
6	VDR_22108803_ChIP-Seq_LS180_Human	2.98329831
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.92878216
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.87579723
9	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.82588682
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.72274890
11	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.62078480
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.49035478
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.43409609
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.38462350
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.31807048
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.29085770
17	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.26417550
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.23333626
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.16820091
20	EWS_26573619_Chip-Seq_HEK293_Human	2.15098408
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04987008
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.97444826
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.84162561
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.83648098
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.74046556
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.71689953
27	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.68981525
28	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.68918146
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.66368001
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.65861597
31	GBX2_23144817_ChIP-Seq_PC3_Human	1.57299915
32	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.56968734
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55946287
34	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.54897185
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.53342624
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.50071512
37	GABP_19822575_ChIP-Seq_HepG2_Human	1.45390385
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.38656672
39	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.35644172
40	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.35644024
41	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.31701853
42	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.29709925
43	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.28000907
44	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.27350464
45	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.26609633
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26337824
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26332381
48	BCAT_22108803_ChIP-Seq_LS180_Human	1.25849477
49	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.25309473
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.25228340
51	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.22858243
52	FUS_26573619_Chip-Seq_HEK293_Human	1.21212071
53	AR_20517297_ChIP-Seq_VCAP_Human	1.21071445
54	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.18821122
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18097228
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18097228
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.17959019
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17959019
59	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.17490505
60	CDX2_22108803_ChIP-Seq_LS180_Human	1.17244379
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16936298
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15332911
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15332911
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13059911
65	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12940717
66	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.12900601
67	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12544133
68	MYC_18940864_ChIP-ChIP_HL60_Human	1.11723903
69	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.11221281
70	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.09627026
71	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.09203595
72	P300_19829295_ChIP-Seq_ESCs_Human	1.08424985
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05230697
74	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03387071
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03004656
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.01568515
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.01310068
78	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.01028877
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00706829
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99524399
81	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.97658440
82	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.95858997
83	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.94563535
84	TFEB_21752829_ChIP-Seq_HELA_Human	0.94444686
85	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.93325521
86	TCF4_22108803_ChIP-Seq_LS180_Human	0.92679574
87	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.91395986
88	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.91209218
89	RBPJ_21746931_ChIP-Seq_IB4_Human	0.91141396
90	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.91110394
91	AR_21909140_ChIP-Seq_LNCAP_Human	0.91004795
92	TP53_22573176_ChIP-Seq_HFKS_Human	0.89908594
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.89298061
94	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.88951174
95	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.88656914
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.88406888
97	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.88248763
98	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.87166846
99	TAF15_26573619_Chip-Seq_HEK293_Human	0.85965735
100	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.85205450

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	6.22312616
2	MP0000372_irregular_coat_pigmentation	4.95740570
3	MP0005075_abnormal_melanosome_morpholog	4.18595426
4	MP0003646_muscle_fatigue	3.78813829
5	MP0002102_abnormal_ear_morphology	3.76000418
6	MP0005171_absent_coat_pigmentation	3.59610440
7	MP0003195_calcinosis	3.19441899
8	MP0005408_hypopigmentation	2.83090643
9	MP0008057_abnormal_DNA_replication	2.81940031
10	MP0003950_abnormal_plasma_membrane	2.71296132
11	MP0010094_abnormal_chromosome_stability	2.68479121
12	MP0008058_abnormal_DNA_repair	2.58512614
13	MP0004885_abnormal_endolymph	2.41838153
14	MP0006292_abnormal_olfactory_placode	2.24728080
15	MP0003693_abnormal_embryo_hatching	2.21571858
16	MP0004381_abnormal_hair_follicle	2.19651455
17	MP0005174_abnormal_tail_pigmentation	2.16665358
18	MP0006036_abnormal_mitochondrial_physio	2.09223724
19	MP0000015_abnormal_ear_pigmentation	2.00746080
20	MP0002095_abnormal_skin_pigmentation	1.86577187
21	MP0003136_yellow_coat_color	1.83194123
22	MP0004957_abnormal_blastocyst_morpholog	1.82303986
23	MP0009046_muscle_twitch	1.79198952
24	MP0008872_abnormal_physiological_respon	1.78706320
25	MP0002938_white_spotting	1.78320359
26	MP0000371_diluted_coat_color	1.73430146
27	MP0010234_abnormal_vibrissa_follicle	1.68075546
28	MP0003786_premature_aging	1.66090506
29	MP0002006_tumorigenesis	1.63364355
30	MP0002090_abnormal_vision	1.58922894
31	MP0002138_abnormal_hepatobiliary_system	1.56298897
32	MP0003718_maternal_effect	1.47324409
33	MP0008875_abnormal_xenobiotic_pharmacok	1.41777762
34	MP0002837_dystrophic_cardiac_calcinosis	1.41316112
35	MP0003077_abnormal_cell_cycle	1.41286376
36	MP0003111_abnormal_nucleus_morphology	1.40790644
37	MP0006035_abnormal_mitochondrial_morpho	1.39963267
38	MP0001324_abnormal_eye_pigmentation	1.37938703
39	MP0006072_abnormal_retinal_apoptosis	1.34746331
40	MP0000569_abnormal_digit_pigmentation	1.30652861
41	MP0003252_abnormal_bile_duct	1.30647458
42	MP0005084_abnormal_gallbladder_morpholo	1.28560404
43	MP0005377_hearing/vestibular/ear_phenot	1.28181213
44	MP0003878_abnormal_ear_physiology	1.28181213
45	MP0008877_abnormal_DNA_methylation	1.24585200
46	MP0010386_abnormal_urinary_bladder	1.21216289
47	MP0006054_spinal_hemorrhage	1.18271984
48	MP0005266_abnormal_metabolism	1.17496555
49	MP0009697_abnormal_copulation	1.16684455
50	MP0008007_abnormal_cellular_replicative	1.12902081
51	MP0002277_abnormal_respiratory_mucosa	1.11220332
52	MP0005551_abnormal_eye_electrophysiolog	1.05392949
53	MP0001501_abnormal_sleep_pattern	1.05236577
54	MP0001984_abnormal_olfaction	1.04819677
55	MP0004147_increased_porphyrin_level	1.04187819
56	MP0005253_abnormal_eye_physiology	0.99015121
57	MP0002075_abnormal_coat/hair_pigmentati	0.98245429
58	MP0005379_endocrine/exocrine_gland_phen	0.92602876
59	MP0006276_abnormal_autonomic_nervous	0.86578915
60	MP0001929_abnormal_gametogenesis	0.85626990
61	MP0010678_abnormal_skin_adnexa	0.83157688
62	MP0001881_abnormal_mammary_gland	0.82052438
63	MP0002928_abnormal_bile_duct	0.79982469
64	MP0002166_altered_tumor_susceptibility	0.77430142
65	MP0001186_pigmentation_phenotype	0.76725746
66	MP0001919_abnormal_reproductive_system	0.75909881
67	MP0009765_abnormal_xenobiotic_induced	0.73601239
68	MP0002229_neurodegeneration	0.69820082
69	MP0005389_reproductive_system_phenotype	0.69322304
70	MP0001764_abnormal_homeostasis	0.68514330
71	MP0002210_abnormal_sex_determination	0.68139848
72	MP0000647_abnormal_sebaceous_gland	0.65150493
73	MP0004043_abnormal_pH_regulation	0.64755000
74	MP0001661_extended_life_span	0.63950213
75	MP0002272_abnormal_nervous_system	0.61582259
76	MP0003186_abnormal_redox_activity	0.60190642
77	MP0003936_abnormal_reproductive_system	0.59740195
78	MP0005646_abnormal_pituitary_gland	0.59533059
79	MP0008995_early_reproductive_senescence	0.59405018
80	MP0003698_abnormal_male_reproductive	0.59397659
81	MP0004215_abnormal_myocardial_fiber	0.59269234
82	MP0000631_abnormal_neuroendocrine_gland	0.58967148
83	MP0000358_abnormal_cell_content/	0.58829924
84	MP0003283_abnormal_digestive_organ	0.55515052
85	MP0001293_anophthalmia	0.55327561
86	MP0000383_abnormal_hair_follicle	0.55191808
87	MP0002139_abnormal_hepatobiliary_system	0.54931122
88	MP0008775_abnormal_heart_ventricle	0.54760813
89	MP0003172_abnormal_lysosome_physiology	0.54433964
90	MP0001756_abnormal_urination	0.53091285
91	MP0009745_abnormal_behavioral_response	0.52401050
92	MP0009764_decreased_sensitivity_to	0.52332260
93	MP0001529_abnormal_vocalization	0.52242645
94	MP0002163_abnormal_gland_morphology	0.51876515
95	MP0000427_abnormal_hair_cycle	0.51550382
96	MP0005332_abnormal_amino_acid	0.51043720
97	MP0002160_abnormal_reproductive_system	0.50876190
98	MP0005636_abnormal_mineral_homeostasis	0.49846429
99	MP0000653_abnormal_sex_gland	0.48753831
100	MP0001666_abnormal_nutrient_absorption	0.48517160

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Median cleft lip (HP:0000161)	3.64418186
2	Pancreatic cysts (HP:0001737)	3.39646502
3	Abnormality of the labia minora (HP:0012880)	3.33862375
4	Adrenal hypoplasia (HP:0000835)	3.32493254
5	Pancreatic fibrosis (HP:0100732)	3.19018847
6	Large for gestational age (HP:0001520)	3.12426652
7	Acute necrotizing encephalopathy (HP:0006965)	3.12348334
8	Type I transferrin isoform profile (HP:0003642)	3.09505807
9	Increased CSF lactate (HP:0002490)	3.06648054
10	Medial flaring of the eyebrow (HP:0010747)	2.96839339
11	Hepatic necrosis (HP:0002605)	2.87795622
12	Mitochondrial inheritance (HP:0001427)	2.87667918
13	Congenital stationary night blindness (HP:0007642)	2.85958194
14	Acute encephalopathy (HP:0006846)	2.84211992
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.82997775
16	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.79274313
17	Hypoplasia of the fovea (HP:0007750)	2.79274313
18	Gonadal dysgenesis (HP:0000133)	2.73721310
19	Hepatocellular necrosis (HP:0001404)	2.72380481
20	Progressive macrocephaly (HP:0004481)	2.69628514
21	Opisthotonus (HP:0002179)	2.69211904
22	Sex reversal (HP:0012245)	2.55306362
23	Abnormal sex determination (HP:0012244)	2.55306362
24	Molar tooth sign on MRI (HP:0002419)	2.55011408
25	Abnormality of midbrain morphology (HP:0002418)	2.55011408
26	Patchy hypopigmentation of hair (HP:0011365)	2.49266945
27	Cerebral edema (HP:0002181)	2.48845993
28	Gaze-evoked nystagmus (HP:0000640)	2.47240518
29	Ependymoma (HP:0002888)	2.42509928
30	Abnormality of the renal cortex (HP:0011035)	2.41962735
31	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.40317403
32	Tubulointerstitial nephritis (HP:0001970)	2.40007837
33	Clubbing of toes (HP:0100760)	2.39607152
34	Abnormality of chromosome stability (HP:0003220)	2.37085919
35	Renal cortical cysts (HP:0000803)	2.36666703
36	Mesomelia (HP:0003027)	2.34933682
37	Congenital primary aphakia (HP:0007707)	2.33595060
38	Abnormality of methionine metabolism (HP:0010901)	2.33441148
39	Ocular albinism (HP:0001107)	2.32632383
40	Increased serum lactate (HP:0002151)	2.32350554
41	True hermaphroditism (HP:0010459)	2.31691512
42	Aplasia cutis congenita (HP:0001057)	2.30947746
43	Chromsome breakage (HP:0040012)	2.30815741
44	Aplasia/Hypoplasia of the macula (HP:0008059)	2.28966118
45	Congenital hepatic fibrosis (HP:0002612)	2.28327099
46	Congenital, generalized hypertrichosis (HP:0004540)	2.27599492
47	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.25742718
48	Abnormal protein glycosylation (HP:0012346)	2.25705330
49	Abnormal glycosylation (HP:0012345)	2.25705330
50	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.25705330
51	Abnormal protein N-linked glycosylation (HP:0012347)	2.25705330
52	Male pseudohermaphroditism (HP:0000037)	2.24265773
53	Gait imbalance (HP:0002141)	2.23356368
54	Meckel diverticulum (HP:0002245)	2.21935351
55	Abnormality of the pons (HP:0007361)	2.20344719
56	Abnormality of the fovea (HP:0000493)	2.19483798
57	Abnormality of the ileum (HP:0001549)	2.18916295
58	Large eyes (HP:0001090)	2.17520904
59	Nephrogenic diabetes insipidus (HP:0009806)	2.17423803
60	Hypoplasia of the pons (HP:0012110)	2.16464938
61	Abnormality of lateral ventricle (HP:0030047)	2.15774078
62	Methylmalonic acidemia (HP:0002912)	2.15102823
63	Duplicated collecting system (HP:0000081)	2.14379098
64	Abnormality of the preputium (HP:0100587)	2.13776409
65	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.13633031
66	Abnormality of the renal collecting system (HP:0004742)	2.11500094
67	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.11180515
68	Iris hypopigmentation (HP:0007730)	2.11108296
69	Abnormality of glycolysis (HP:0004366)	2.08084287
70	Nephronophthisis (HP:0000090)	2.07868633
71	Female pseudohermaphroditism (HP:0010458)	2.06276267
72	Cystic liver disease (HP:0006706)	2.03820639
73	Lipid accumulation in hepatocytes (HP:0006561)	2.03257769
74	Astigmatism (HP:0000483)	1.99717591
75	Renal Fanconi syndrome (HP:0001994)	1.99647423
76	Increased hepatocellular lipid droplets (HP:0006565)	1.99546778
77	3-Methylglutaconic aciduria (HP:0003535)	1.99538539
78	Small intestinal stenosis (HP:0012848)	1.99152052
79	Duodenal stenosis (HP:0100867)	1.99152052
80	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.96557063
81	Hypoglycemic coma (HP:0001325)	1.95062445
82	Facial cleft (HP:0002006)	1.93006198
83	Limb hypertonia (HP:0002509)	1.92343586
84	Neoplasm of the adrenal cortex (HP:0100641)	1.90190842
85	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.88463013
86	Absent/shortened dynein arms (HP:0200106)	1.88463013
87	Genital tract atresia (HP:0001827)	1.87398663
88	Abnormality of the renal medulla (HP:0100957)	1.86399435
89	Birth length less than 3rd percentile (HP:0003561)	1.85621129
90	Ovarian neoplasm (HP:0100615)	1.84574624
91	Nausea (HP:0002018)	1.83692959
92	Neoplasm of the adrenal gland (HP:0100631)	1.82436644
93	Oligohydramnios (HP:0001562)	1.81969790
94	Methylmalonic aciduria (HP:0012120)	1.81441891
95	Testicular neoplasm (HP:0010788)	1.78695212
96	Abolished electroretinogram (ERG) (HP:0000550)	1.78255888
97	Abnormality of renal resorption (HP:0011038)	1.78201620
98	Postaxial hand polydactyly (HP:0001162)	1.77655716
99	Lethargy (HP:0001254)	1.76010880
100	Asplenia (HP:0001746)	1.75571778

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	7.15575337
2	FRK	3.74755637
3	MST4	3.53337098
4	EIF2AK3	3.15180172
5	WEE1	3.09294711
6	ACVR1B	2.95154752
7	FER	2.85275093
8	FES	2.80530588
9	TSSK6	2.75107128
10	STK16	2.44861234
11	NUAK1	2.43102704
12	PNCK	2.34903713
13	BUB1	2.11475273
14	EIF2AK1	2.08326243
15	PDK2	2.02493670
16	PLK3	1.78649944
17	TRIM28	1.69086708
18	PBK	1.67308066
19	ALK	1.61418092
20	BMPR1B	1.60668108
21	GRK1	1.54665771
22	PLK2	1.51985772
23	NEK1	1.40066249
24	VRK2	1.36253403
25	CCNB1	1.35991863
26	WNK3	1.26625189
27	TAF1	1.25095440
28	PINK1	1.23243112
29	ADRBK2	1.18366895
30	TEC	1.11154676
31	DAPK1	1.11022229
32	SRPK1	1.10401391
33	EIF2AK2	1.05844965
34	GRK5	0.97056860
35	OXSR1	0.93360704
36	MAP3K12	0.92654589
37	PLK1	0.91320744
38	PLK4	0.90057962
39	MAPK13	0.89036829
40	TTK	0.87144807
41	MYLK	0.85434147
42	MKNK2	0.84443399
43	PTK2B	0.81265768
44	ERBB3	0.79482143
45	CDC7	0.76406259
46	ATR	0.72477836
47	CHEK2	0.71207079
48	TNIK	0.71134828
49	STK3	0.68977864
50	ZAK	0.66439927
51	FLT3	0.65024171
52	NEK2	0.64128912
53	TGFBR1	0.64022874
54	STK39	0.63372846
55	VRK1	0.62876406
56	PRKCE	0.60955729
57	SIK3	0.60319625
58	AKT3	0.58394043
59	NME1	0.57546829
60	CSNK1A1	0.53289784
61	ATM	0.51572295
62	MKNK1	0.50293057
63	MAP4K2	0.47109105
64	GRK6	0.46568408
65	CSNK1E	0.45051810
66	INSRR	0.43196452
67	PRKCG	0.41008846
68	PHKG2	0.39531004
69	PHKG1	0.39531004
70	STK4	0.39285571
71	FGR	0.39208620
72	TNK2	0.39152533
73	TIE1	0.38968308
74	FGFR1	0.38344883
75	PAK6	0.36908233
76	ADRBK1	0.36564059
77	KIT	0.35703069
78	BMPR2	0.35479834
79	FGFR2	0.35331762
80	TXK	0.34851606
81	CSNK2A1	0.34838834
82	PAK3	0.33088841
83	ERBB4	0.31504658
84	IKBKB	0.31132038
85	CSNK1G1	0.30955142
86	CAMK2A	0.30789534
87	CHEK1	0.29996901
88	TGFBR2	0.29565706
89	CDK3	0.29303159
90	STK38L	0.28846664
91	MAPK11	0.28586835
92	CAMK1	0.27414153
93	CSNK1D	0.26255778
94	CSNK1G3	0.25981958
95	AURKB	0.24512497
96	BCKDK	0.24441320
97	DAPK3	0.24116059
98	PRKCA	0.24020844
99	MAPKAPK5	0.23087999
100	IRAK1	0.22925673

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.53179277
2	Homologous recombination_Homo sapiens_hsa03440	2.83348471
3	Protein export_Homo sapiens_hsa03060	2.78193298
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.67200784
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.62606868
6	Parkinsons disease_Homo sapiens_hsa05012	2.53135096
7	DNA replication_Homo sapiens_hsa03030	2.51521496
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.46533539
9	Mismatch repair_Homo sapiens_hsa03430	2.37894249
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.34003980
11	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.25279018
12	One carbon pool by folate_Homo sapiens_hsa00670	2.13477445
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.95879575
14	Sulfur metabolism_Homo sapiens_hsa00920	1.89645400
15	Base excision repair_Homo sapiens_hsa03410	1.88069708
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.84341404
17	RNA transport_Homo sapiens_hsa03013	1.71882338
18	Propanoate metabolism_Homo sapiens_hsa00640	1.66372571
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.64980462
20	Glutathione metabolism_Homo sapiens_hsa00480	1.62486027
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.59703156
22	RNA degradation_Homo sapiens_hsa03018	1.57850350
23	Sulfur relay system_Homo sapiens_hsa04122	1.50746111
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45625694
25	Basal transcription factors_Homo sapiens_hsa03022	1.44056729
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.41167255
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39643946
28	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.35929373
29	RNA polymerase_Homo sapiens_hsa03020	1.31994507
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.31645223
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.29910617
32	Huntingtons disease_Homo sapiens_hsa05016	1.29054461
33	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.27974684
34	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.22462981
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.20966953
36	Alzheimers disease_Homo sapiens_hsa05010	1.20325033
37	Folate biosynthesis_Homo sapiens_hsa00790	1.19071912
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.19013269
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.18445748
40	Phototransduction_Homo sapiens_hsa04744	1.14755769
41	Purine metabolism_Homo sapiens_hsa00230	1.14482982
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.13740562
43	Glycerolipid metabolism_Homo sapiens_hsa00561	1.10396994
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.10343106
45	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.98260156
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.97394629
47	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.96514173
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95744765
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94752201
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.93840314
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93835911
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90985979
53	Pentose phosphate pathway_Homo sapiens_hsa00030	0.90159566
54	Caffeine metabolism_Homo sapiens_hsa00232	0.89300636
55	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.88114436
56	Retinol metabolism_Homo sapiens_hsa00830	0.87232518
57	Fatty acid degradation_Homo sapiens_hsa00071	0.86941441
58	p53 signaling pathway_Homo sapiens_hsa04115	0.86792267
59	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.85973820
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.85023714
61	Cell cycle_Homo sapiens_hsa04110	0.84488402
62	Peroxisome_Homo sapiens_hsa04146	0.82339465
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.81314758
64	Butanoate metabolism_Homo sapiens_hsa00650	0.80956596
65	Tyrosine metabolism_Homo sapiens_hsa00350	0.80875930
66	Olfactory transduction_Homo sapiens_hsa04740	0.79555501
67	Metabolic pathways_Homo sapiens_hsa01100	0.78673655
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.78635703
69	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.78216242
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.76044324
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.75159573
72	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.72847153
73	Lysine degradation_Homo sapiens_hsa00310	0.69656907
74	Fatty acid elongation_Homo sapiens_hsa00062	0.69136341
75	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.68955255
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67020383
77	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.66951765
78	Nitrogen metabolism_Homo sapiens_hsa00910	0.63100535
79	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.60884183
80	Oocyte meiosis_Homo sapiens_hsa04114	0.57374883
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.55822111
82	Linoleic acid metabolism_Homo sapiens_hsa00591	0.53851858
83	Carbon metabolism_Homo sapiens_hsa01200	0.53116255
84	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.49429280
85	Regulation of autophagy_Homo sapiens_hsa04140	0.46556725
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.44396272
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.43489436
88	Histidine metabolism_Homo sapiens_hsa00340	0.42803062
89	Pancreatic secretion_Homo sapiens_hsa04972	0.42615312
90	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.42377953
91	Primary immunodeficiency_Homo sapiens_hsa05340	0.39920596
92	Steroid biosynthesis_Homo sapiens_hsa00100	0.39380247
93	Spliceosome_Homo sapiens_hsa03040	0.39098472
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35881993
95	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.35834363
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.34724209
97	Ether lipid metabolism_Homo sapiens_hsa00565	0.34262796
98	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32950647
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.30099859
100	Sphingolipid metabolism_Homo sapiens_hsa00600	0.27488671

SLC25A5P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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